{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12756","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12756/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12756/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12756/events","html_url":"https://github.com/geneontology/go-ontology/issues/12756","id":184251055,"number":12756,"title":"NTR: tRNA 5'-end processing / children of RNA repair? / 3′-5′ RNA polymerase activity","user":{"login":"pfey03","id":1349602,"avatar_url":"https://avatars.githubusercontent.com/u/1349602?v=3","gravatar_id":"","url":"https://api.github.com/users/pfey03","html_url":"https://github.com/pfey03","followers_url":"https://api.github.com/users/pfey03/followers","following_url":"https://api.github.com/users/pfey03/following{/other_user}","gists_url":"https://api.github.com/users/pfey03/gists{/gist_id}","starred_url":"https://api.github.com/users/pfey03/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/pfey03/subscriptions","organizations_url":"https://api.github.com/users/pfey03/orgs","repos_url":"https://api.github.com/users/pfey03/repos","events_url":"https://api.github.com/users/pfey03/events{/privacy}","received_events_url":"https://api.github.com/users/pfey03/received_events","type":"User","site_admin":false},"labels":[{"id":465434662,"url":"https://api.github.com/repos/geneontology/go-ontology/labels/dictyBase","name":"dictyBase","color":"01A9DB","default":false},{"id":240250556,"url":"https://api.github.com/repos/geneontology/go-ontology/labels/New%20term%20request","name":"New term request","color":"bfe5bf","default":false}],"state":"open","locked":false,"assignee":{"login":"paolaroncaglia","id":4982516,"avatar_url":"https://avatars.githubusercontent.com/u/4982516?v=3","gravatar_id":"","url":"https://api.github.com/users/paolaroncaglia","html_url":"https://github.com/paolaroncaglia","followers_url":"https://api.github.com/users/paolaroncaglia/followers","following_url":"https://api.github.com/users/paolaroncaglia/following{/other_user}","gists_url":"https://api.github.com/users/paolaroncaglia/gists{/gist_id}","starred_url":"https://api.github.com/users/paolaroncaglia/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/paolaroncaglia/subscriptions","organizations_url":"https://api.github.com/users/paolaroncaglia/orgs","repos_url":"https://api.github.com/users/paolaroncaglia/repos","events_url":"https://api.github.com/users/paolaroncaglia/events{/privacy}","received_events_url":"https://api.github.com/users/paolaroncaglia/received_events","type":"User","site_admin":false},"assignees":[{"login":"paolaroncaglia","id":4982516,"avatar_url":"https://avatars.githubusercontent.com/u/4982516?v=3","gravatar_id":"","url":"https://api.github.com/users/paolaroncaglia","html_url":"https://github.com/paolaroncaglia","followers_url":"https://api.github.com/users/paolaroncaglia/followers","following_url":"https://api.github.com/users/paolaroncaglia/following{/other_user}","gists_url":"https://api.github.com/users/paolaroncaglia/gists{/gist_id}","starred_url":"https://api.github.com/users/paolaroncaglia/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/paolaroncaglia/subscriptions","organizations_url":"https://api.github.com/users/paolaroncaglia/orgs","repos_url":"https://api.github.com/users/paolaroncaglia/repos","events_url":"https://api.github.com/users/paolaroncaglia/events{/privacy}","received_events_url":"https://api.github.com/users/paolaroncaglia/received_events","type":"User","site_admin":false}],"milestone":null,"comments":5,"created_at":"2016-10-20T14:48:57Z","updated_at":"2016-10-28T12:15:28Z","closed_at":null,"body":"I have several papers about 4 Dicty 3′-5′ RNA polymerases that describe different functions for each. One is Dicty Thg1, which has the same tRNA guanylyltransferase activity (GO:0008193) as yeast THG1. The other 3, Tlp2-4 (Thg1- Like Proteins) also have 3′-5′ RNA polymerase activity (no such term in GO), but each acts differently (PMID:27484477, also PMID:26143376, PMID: 21307182)\r\n\r\n- Tlp2: catalyzes a mitochondria-specific tRNAHis maturation reaction, which is distinct from the tRNAHis maturation reaction typically catalyzed by Thg1 on cytosolic tRNA.\r\n\r\n- Tlp3: catalyzes tRNA repair during mitochondrial tRNA 5′-editing in vivo and in vitro showing 3′-5′ RNA polymerase activity of TLPs as a bona fide biological activity.\r\n\r\n- Tlp4: cytosolic, and catalyzes robust 3′-5′ polymerase activity on non-tRNA substrates (other ncRNAs).\r\n\r\nA) New terms:\r\n\r\n1) tRNA 5'-end processing / mitochondrial  tRNA 5'-end processing\r\n. . <- GO:0090646 tRNA processing\r\n. . . <- GO:1990180 mitochondrial tRNA 3'-end processing\r\n. . . <- **GO:New: mitochondrial tRNA 5'-end processing**\r\n\r\n2) Children of RNA repair (suggested, can be discussed if specific 5' terms are necessary in conjunction with other terms)\r\n. . <- GO:0042245 RNA repair\r\n. . . <- **GO:New: tRNA repair**\r\n. . . . <- **GO:New: mitochondrial tRNA repair**\r\n\r\n3) 3′-5′ RNA polymerase activity  - all DNA/RNA polymerase/transcription activity by default is 3' → 5' , so not sure what parentage could be, certainly not regular transcription, RNA-templated - maybe even up to RNA metabolic process?\r\n. . <- **GO:New: 3′-5′ RNA polymerase activity**\r\n\r\nThanks! \r\nPetra\r\n\r\n\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/256905449","html_url":"https://github.com/geneontology/go-ontology/issues/12756#issuecomment-256905449","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12756","id":256905449,"user":{"login":"paolaroncaglia","id":4982516,"avatar_url":"https://avatars.githubusercontent.com/u/4982516?v=3","gravatar_id":"","url":"https://api.github.com/users/paolaroncaglia","html_url":"https://github.com/paolaroncaglia","followers_url":"https://api.github.com/users/paolaroncaglia/followers","following_url":"https://api.github.com/users/paolaroncaglia/following{/other_user}","gists_url":"https://api.github.com/users/paolaroncaglia/gists{/gist_id}","starred_url":"https://api.github.com/users/paolaroncaglia/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/paolaroncaglia/subscriptions","organizations_url":"https://api.github.com/users/paolaroncaglia/orgs","repos_url":"https://api.github.com/users/paolaroncaglia/repos","events_url":"https://api.github.com/users/paolaroncaglia/events{/privacy}","received_events_url":"https://api.github.com/users/paolaroncaglia/received_events","type":"User","site_admin":false},"created_at":"2016-10-28T12:15:28Z","updated_at":"2016-10-28T12:15:28Z","body":"Hi again @pfey03 ,\r\n\r\nWrt your requests number 2) for GO:New: tRNA repair and GO:New: mitochondrial tRNA repair, are those processes really different from their parent GO:0042245 RNA repair? Do they occur differently? It sounds as if it’d be better to annotate to ‘RNA repair’ and add annotation extensions for GO ’mitochondrion’ and SO ‘tRNA’. But if those processes should indeed be represented by separate terms, please suggest definitions for both to underline the differentia, and confirm which PMID(s) I should attach to each term among the ones you indicated (i.e. PMID:27484477, PMID:26143376, PMID: 21307182).\r\n\r\nThanks!"}}
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