{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12322","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12322/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12322/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12322/events","html_url":"https://github.com/geneontology/go-ontology/issues/12322","id":138153697,"number":12322,"title":"regulation of metalloenzyme activity","user":{"login":"rebeccafoulger","id":12291697,"avatar_url":"https://avatars.githubusercontent.com/u/12291697?v=3","gravatar_id":"","url":"https://api.github.com/users/rebeccafoulger","html_url":"https://github.com/rebeccafoulger","followers_url":"https://api.github.com/users/rebeccafoulger/followers","following_url":"https://api.github.com/users/rebeccafoulger/following{/other_user}","gists_url":"https://api.github.com/users/rebeccafoulger/gists{/gist_id}","starred_url":"https://api.github.com/users/rebeccafoulger/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/rebeccafoulger/subscriptions","organizations_url":"https://api.github.com/users/rebeccafoulger/orgs","repos_url":"https://api.github.com/users/rebeccafoulger/repos","events_url":"https://api.github.com/users/rebeccafoulger/events{/privacy}","received_events_url":"https://api.github.com/users/rebeccafoulger/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/enzymes","name":"enzymes","color":"ededed"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/Other%20term-related%20request","name":"Other term-related request","color":"bfe5bf"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/PARL-UCL","name":"PARL-UCL","color":"bfd4f2"}],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":8,"created_at":"2016-03-03T11:34:02Z","updated_at":"2016-03-03T14:02:07Z","closed_at":null,"body":"It looks odd to have the following 6 terms, without a 'metalloenzyme activity' term itself:\r\n\r\nregulation of metalloenzyme activity ; GO:0048552\r\nnegative regulation of metalloenzyme activity ; GO:0048553\r\npositive regulation of metalloenzyme activity ; GO:0048554\r\n\r\nmetalloenzyme regulator activity ; GO:0010576\r\nmetalloenzyme inhibitor activity ; GO:0048551\r\nmetalloenzyme activator activity ; GO:0010577\r\n\r\nPresumably a metalloenzyme term is describing a mechanism, but so are lots of existing terms that describe metalloenzymes:\r\nmetallopeptidase activity ; GO:0008237\r\nmetalloexopeptidase activity ; GO:0008235 etc\r\n\r\nThe regulator terms also aren't currently linked to the regulation terms.\r\n\r\nSo this bit of the ontology needs a bit of tidying. Putting it here to keep track of.\r\nThanks!\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/191773251","html_url":"https://github.com/geneontology/go-ontology/issues/12322#issuecomment-191773251","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12322","id":191773251,"user":{"login":"dosumis","id":112839,"avatar_url":"https://avatars.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"created_at":"2016-03-03T14:02:07Z","updated_at":"2016-03-03T14:02:07Z","body":"Don't see a problem with having specific terms, even if the most general is not sustainable, especially where they are covered by EC.  These two look like they cover metallopeptidases:\r\n\r\nhttp://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/4/24/ http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/4/17/  \r\n\r\nQu"}}