{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12193","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12193/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12193/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12193/events","html_url":"https://github.com/geneontology/go-ontology/issues/12193","id":121328294,"number":12193,"title":"NTR - CC mitochondrion-derived vesicle and BP child of GO:0016192 vesicle-mediated transport","user":{"login":"Pauldenny","id":12345463,"avatar_url":"https://avatars.githubusercontent.com/u/12345463?v=3","gravatar_id":"","url":"https://api.github.com/users/Pauldenny","html_url":"https://github.com/Pauldenny","followers_url":"https://api.github.com/users/Pauldenny/followers","following_url":"https://api.github.com/users/Pauldenny/following{/other_user}","gists_url":"https://api.github.com/users/Pauldenny/gists{/gist_id}","starred_url":"https://api.github.com/users/Pauldenny/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/Pauldenny/subscriptions","organizations_url":"https://api.github.com/users/Pauldenny/orgs","repos_url":"https://api.github.com/users/Pauldenny/repos","events_url":"https://api.github.com/users/Pauldenny/events{/privacy}","received_events_url":"https://api.github.com/users/Pauldenny/received_events","type":"User","site_admin":false},"labels":[{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/autophagy","name":"autophagy","color":"ededed"},{"url":"https://api.github.com/repos/geneontology/go-ontology/labels/PARL-UCL","name":"PARL-UCL","color":"bfd4f2"}],"state":"open","locked":false,"assignee":{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false},"assignees":[{"login":"ukemi","id":11067494,"avatar_url":"https://avatars.githubusercontent.com/u/11067494?v=3","gravatar_id":"","url":"https://api.github.com/users/ukemi","html_url":"https://github.com/ukemi","followers_url":"https://api.github.com/users/ukemi/followers","following_url":"https://api.github.com/users/ukemi/following{/other_user}","gists_url":"https://api.github.com/users/ukemi/gists{/gist_id}","starred_url":"https://api.github.com/users/ukemi/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ukemi/subscriptions","organizations_url":"https://api.github.com/users/ukemi/orgs","repos_url":"https://api.github.com/users/ukemi/repos","events_url":"https://api.github.com/users/ukemi/events{/privacy}","received_events_url":"https://api.github.com/users/ukemi/received_events","type":"User","site_admin":false}],"milestone":null,"comments":3,"created_at":"2015-12-09T20:10:01Z","updated_at":"2016-08-18T13:30:23Z","closed_at":null,"body":"Based on\r\nPMID: 18207745\r\nPMID: 23300790\r\nPMID: 22226745\r\nPMID: 20619655\r\nI think we need a new CC  \r\n\"mitochondrion-derived vesicle\" (MDV)\r\nchild of GO:0031982 vesicle\r\nAuthors (PMID: 18207745) describe these as \"highly distinct structures, 70–100 nm in diameter, emanating from the sides of the mitochondria\". Also \"... resembling intracellular-transport vesicles that were not attached to the larger mitochondria (Figure 1D, top left). They often contained inner mitochondrial membrane; however, cristae were rarely observed and, instead, the outer and inner membranes appeared as two concentric circles (Figure 1D, top left).\"\r\nAlso a BP which would be a child of \r\nGO:0016192 vesicle-mediated transport (I think)\r\nNot sure what to call this new process - intracellular mitochondrial vesicle transport?\r\nIn PMID: 20619655 , authors characterise regulation of this process and show \"Silencing of Vps35 or Vps26A leads to a significant reduction in the delivery of MAPL to peroxisomes, placing the retromer within a novel intracellular trafficking route and providing insight into the formation of MAPL-positive MDVs\"\r\nI'd like to use these terms to annotate proteins in these papers, because they relate to a novel mitochondrial quality-control process involving PINK1 and parkin.\r\n \r\nGOC:pad\r\nGOC:PARL\r\n \r\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/240723086","html_url":"https://github.com/geneontology/go-ontology/issues/12193#issuecomment-240723086","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12193","id":240723086,"user":{"login":"BarbaraCzub","id":16541096,"avatar_url":"https://avatars.githubusercontent.com/u/16541096?v=3","gravatar_id":"","url":"https://api.github.com/users/BarbaraCzub","html_url":"https://github.com/BarbaraCzub","followers_url":"https://api.github.com/users/BarbaraCzub/followers","following_url":"https://api.github.com/users/BarbaraCzub/following{/other_user}","gists_url":"https://api.github.com/users/BarbaraCzub/gists{/gist_id}","starred_url":"https://api.github.com/users/BarbaraCzub/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/BarbaraCzub/subscriptions","organizations_url":"https://api.github.com/users/BarbaraCzub/orgs","repos_url":"https://api.github.com/users/BarbaraCzub/repos","events_url":"https://api.github.com/users/BarbaraCzub/events{/privacy}","received_events_url":"https://api.github.com/users/BarbaraCzub/received_events","type":"User","site_admin":false},"created_at":"2016-08-18T13:30:23Z","updated_at":"2016-08-18T13:30:23Z","body":"Thank you, @Pauldenny, for linking these issues."}}
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