{"action":"closed","issue":{"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/326","repository_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List","labels_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/326/labels{/name}","comments_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/326/comments","events_url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/issues/326/events","html_url":"https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues/326","id":95182190,"number":326,"title":"Synthesis of 5-chloro-[1,2,4]triazolo[4,3-a]pyrazine (TZ 2-1)","user":{"login":"tyzhengsydney","id":13214148,"avatar_url":"https://avatars.githubusercontent.com/u/13214148?v=3","gravatar_id":"","url":"https://api.github.com/users/tyzhengsydney","html_url":"https://github.com/tyzhengsydney","followers_url":"https://api.github.com/users/tyzhengsydney/followers","following_url":"https://api.github.com/users/tyzhengsydney/following{/other_user}","gists_url":"https://api.github.com/users/tyzhengsydney/gists{/gist_id}","starred_url":"https://api.github.com/users/tyzhengsydney/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/tyzhengsydney/subscriptions","organizations_url":"https://api.github.com/users/tyzhengsydney/orgs","repos_url":"https://api.github.com/users/tyzhengsydney/repos","events_url":"https://api.github.com/users/tyzhengsydney/events{/privacy}","received_events_url":"https://api.github.com/users/tyzhengsydney/received_events","type":"User","site_admin":false},"labels":[{"id":66339430,"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Being%20Synthesised%20Now","name":"Being Synthesised Now","color":"eb6420","default":false},{"id":75244545,"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Series%204","name":"Series 4","color":"8A0829","default":false},{"id":39021922,"url":"https://api.github.com/repos/OpenSourceMalaria/OSM_To_Do_List/labels/Synthetic%20Chemistry%20Needed","name":"Synthetic Chemistry Needed","color":"d4c5f9","default":false}],"state":"closed","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":2,"created_at":"2015-07-15T12:39:20Z","updated_at":"2016-11-21T12:46:20Z","closed_at":"2016-11-21T12:46:20Z","body":"![5-chloro- 1 2 4 triazolo 4 3-a pyrazine](https://cloud.githubusercontent.com/assets/13214148/8698378/f61112ac-2b40-11e5-80c1-a980e9104a82.png)\n5-chloro-[1,2,4]triazolo[4,3-a]pyrazine (TZ 2-1) Strings: \nClC1=CN=CC2=NN=CN21 \nand \nInChI=1S/C5H3ClN4/c6-4-1-7-2-5-9-8-3-10(4)5/h1-3H\n\nHi I'm Tianyi. I've been working with Alice on the lab for one week. We next plan to synthesise 5-chloro-[1,2,4]triazolo[4,3-a]pyrazine. We make this compound in order to  develop some bromination chemistry and new methods for core synthesis. In this case, we'll develop methods to conduct bromination at 3-position. Reaction conditions are shown below.\nHydrazinylpyrazine (8g, 55.3mmol, 1 equiv.), triethyl orthoformate (18.4 ml, 110.6 mmol, 2 equiv.), and tosylic acid (2.765mmol, 0.05 equiv.) were dissolved in toluene (to around 0.35 M) and heated at reflux for 24 h.\nWe'll see what happens this Thursday morning.\n"}}
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