{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12416","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12416/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12416/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12416/events","html_url":"https://github.com/geneontology/go-ontology/issues/12416","id":150370217,"number":12416,"title":"GO term specificity proposal 1 (generic residues and regulatory subunit dependencies in term names)","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"milestone":null,"comments":3,"created_at":"2016-04-22T13:29:38Z","updated_at":"2016-04-22T13:51:13Z","closed_at":null,"body":"\r\n\r\nWe  always try to annotate as specifically as possible, and encourage our community to do the same.\r\nThis has highlighted a number of pages where  annotations  are sometimes get modelled arbitrarily slightly differently .\r\n\r\nTake for example cdc2 MF annotations below:\r\n\r\n![specificity](https://cloud.githubusercontent.com/assets/7359272/14742573/e1ce19f2-0894-11e6-8cd2-40be714c9405.jpg)\r\n\r\nThe \"protein kinase activity\" is described variously as\r\ncyclin-dependent protein kinase activity\r\ncylin-dependent protein serine/threonine kinase activity\r\nprotein kianse activity\r\nprotein serine/threonine kinase activity.\r\n\r\nFirst, cyclin dependency can be captured by annotating the cyclin correctly.\r\nSecondly the residues are not useful in this context. At the level of GO annotation, it isn't informative to know which general residues are phosphorylated. Its only useful information  if you know which specific residues are phosphorylated in a particular target protein. This should/could be captured on the modified protein, using PRO terms.\r\n\r\ne.g\r\nhttp://www.pombase.org/spombe/result/SPAC24B11.06c#modifications\r\n\r\nbut including this information in the function seems out of scope for GO?\r\n(also applies to protein phosphatase activity  descendants)\r\n\r\nThere are various tickets where this has been discussed, but definite no proposal to merge.\r\n\r\n@pgaudet @thomaspd @dosumis \r\n\r\n\r\n "},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/213437266","html_url":"https://github.com/geneontology/go-ontology/issues/12416#issuecomment-213437266","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12416","id":213437266,"user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars.githubusercontent.com/u/7359272?v=3","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2016-04-22T13:51:13Z","updated_at":"2016-04-22T13:51:13Z","body":"\r\nA similar issue was discussed here with respect to ubiquitin hydrolase residues:\r\nhttps://github.com/geneontology/go-ontology/issues/12182"}}