du-41165 du-41165 du-41165, also known as 6-fluoro-16-methylene-17α-acetoxy-δ6-retroprogesterone, is a progestin which was developed by philips-duphar in the 1970s and was never marketed. it is a combined derivative of 17α-hydroxyprogesterone and retroprogesterone. the drug shows extremely high potency as a progestogen in animals. it has been found to possess 158% of the relative binding affinity of promegestone for the progesterone receptor expressed in rat uterus (relative to 74% for the closely related progestin du-41164). du-41165 also showed 28% of the affinity of ru-28362 for the glucocorticoid receptor expressed in rat liver, but no affinity for the mineralocorticoid receptor expressed in rat kidney (<0.003% of that of ru-26752). the drug showed no androgenic, anabolic, or estrogenic activity in animals, but did show some antiandrogenic and glucocorticoid activity at high doses. although highly potent in animals, du-41165 produced little or no progestogenic effect at dosages of 50 and 200 µg/day in women, suggesting major species differences. du-41165 has been studied as a potential photoaffinity label for the progesterone receptor. du-41165clinical dataother names6-fluoro-16-methylene-17α-acetoxy-δ6-retroprogesterone; 6-fluoro-16-methylene-17α-hydroxy-9β,10α-pregna-4,6-diene-3,20-dione 17α-acetate; 6-fluoro-16-methylene-3,20-dioxo-9β,10α-pregna-4,6-dien-17α-yl acetateroutes ofadministrationby mouthdrug classprogestin; progestogenidentifiers iupac name phenanthren-17-yl] acetate cas number34184-58-2 ypubchem cid169573chemspider148298unii5m4pl394k5comptox dashboard (epa)dtxsid60955729 chemical and physical dataformulac24h29fo4molar mass400.490 g·mol−13d model (jsmol)interactive image smiles cc(=o)1(c(=c)c21(cc32c=c(c4=cc(=o)cc34c)f)c)oc(=o)c inchi inchi=1s/c24h29fo4/c1-13-10-19-17-12-21(25)20-11-16(28)6-8-22(20,4)18(17)7-9-23(19,5)24(13,14(2)26)29-15(3)27/h11-12,17-19h,1,6-10h2,2-5h3/t17-,18-,19+,22+,23+,24+/m1/s1key:xssigsnqdkhhld-jbarxxbasa-n