in the russian region of chuvashia (1 of every 3,500–4,000 newborns) due to genetic traits of the chuvash people. recent research recent research demonstrated that the systematic administration of rankl for one month to rankl(-/-) mice, which closely resemble the human disease, significantly improved the bone phenotype and has beneficial effects on bone marrow, spleen and thymus; major adverse effects arise only when mice are clearly overtreated. overall, it provided evidence that the pharmacological administration of rankl represents the appropriate treatment option for rankl-deficient aro patients, to be validated in a pilot clinical trial. interferon gamma-1b is fda-approved to delay the time to disease progression in patients with severe, malignant osteopetrosis. notable cases laurel burch lil bub