database of systematic reviews. 2015 (10): cd010203. doi:10.1002/14651858.cd010203.pub2. pmc 9270723. pmid 26513223. diseases of jointsgeneral arthritis monoarthritis oligoarthritis polyarthritis symptoms joint pain joint stiffness inflammatoryinfectious septic arthritis tuberculosis arthritis crystal chondrocalcinosis cppd (pseudogout) gout seronegative reactive arthritis psoriatic arthritis ankylosing spondylitis other juvenile idiopathic arthritis rheumatoid arthritis felty's syndrome palindromic rheumatism adult-onset still's disease noninflammatory hemarthrosis osteoarthritis heberden's node bouchard's nodes osteophyte inflammationsymptoms flushing (rubor) fever (calor) swelling (tumor) pain (dolor) loss of function (functio laesa) mechanismacuteplasma-derived mediators bradykinin complement c3 c5a mac coagulation factor xii plasmin thrombin cell-derived mediatorspreformed: lysosome granules biogenic amines histamine serotonin synthesized on demand: cytokines ifn-γ il-8 tnf-α il-1 eicosanoids leukotriene b4 prostaglandins nitric oxide kinins chronic macrophage epithelioid cell giant cell granuloma other acute-phase reaction vasodilation increased vascular permeability exudate leukocyte extravasation chemotaxis tests full blood count leukocytosis c-reactive protein erythrocyte sedimentation rate general lymphadenopathy list of inflammatory disorders this article is issued from wikipedia. the text is licensed under creative commons - attribution - sharealike. additional terms may apply for the media files.