nicotinamide mononucleotide nicotinamide mononucleotide nicotinamide mononucleotide (“nmn” and “β-nmn”) is a nucleotide derived from ribose, nicotinamide, nicotinamide riboside and niacin. in humans, several enzymes use nmn to generate nicotinamide adenine dinucleotide (nadh). in mice, it has been proposed that nmn is absorbed via the small intestine within 10 minutes of oral uptake and converted to nicotinamide adenine dinucleotide (nad+) through the slc12a8 transporter. however, this observation has been challenged, and the matter remains unsettled. nicotinamide mononucleotide names iupac name 3-carbamoyl-1-(5-o-phosphono-β-d-ribofuranosyl)pyridin-1-ium systematic iupac name methyl hydrogen phosphate other names nicotinamide ribonucleoside 5′-phosphatenicotinamide d-ribonucleotideβ-nicotinamide ribose monophosphatenicotinamide nucleotide identifiers cas number 1094-61-7 y 3d model (jsmol) interactive image beilstein reference 3570187 chebi chebi:16171 chembl chembl610238 chemspider 13553 echa infocard 100.012.851 ec number 214-136-5 kegg c00455 pubchem cid 16219737 unii 2kg6qx4w0v y comptox dashboard (epa) dtxsid50911152 inchi inchi=1s/c11h15n2o8p/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15h,5h2,(h3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1key: dayljwodmcoqew-turqnecasa-n smiles c1cc(c(c1)2(((o2)cop(=o)(o))o)o)c(=o)n properties chemical formula c11h15n2o8p molar mass 334.221 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references because nadh is a cofactor for processes inside mitochondria, for sirtuins and parp, nmn has been studied in animal models as a potential neuroprotective and anti-aging agent. the reversal of aging at the cellular level by inhibiting mitochondrial decay in presence of increased levels of nad+ makes it popular among anti-aging products. dietary supplement companies have aggressively marketed nmn products, claiming those benefits. however, no human studies to date have properly proven its anti-aging effects. single-dose administration of up to 500 mg was shown safe in men in a study at keio university. one 2021 clinical trial found that nmn improved muscular insulin sensitivity in prediabetic women, while another found that it improved aerobic capacity in amateur runners. nmn is vulnerable to extracellular degradation by cd38 enzyme, which can be inhibited by compounds such as cd38-in-78c. dietary sources nmn is found in fruits and vegetables such as edamame, broccoli, cabbage, cucumber and avocado at a concentration of about 1 mg per 100g, making these natural sources impractical to acquire the quantities needed to accomplish the dosing currently being investigated for nmn as a pharmaceutical. production production of nicotinamide mononucleotide has been redacted since the latter-half of 2022 by the fda because it is under investigation as a pharmaceutical drug.