tiospirone tiospirone tiospirone (bmy-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. it was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. however, development was halted and it was not marketed. perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone. it was found to be both more potent and more selective in comparison and was commercialized instead. tiospironeclinical dataatc codenonelegal statuslegal status development terminated pharmacokinetic datametabolismhepaticelimination half-life1.4 hoursexcretionurineidentifiers iupac name 8-butyl]-8-azaspirodecane-7,9-dione cas number87691-91-6pubchem cid55752iuphar/bps101chemspider50348unii35c6umo5srchemblchembl35057comptox dashboard (epa)dtxsid90236558 chemical and physical dataformulac24h32n4o2smolar mass440.61 g·mol−1 pharmacology pharmacodynamics tiospirone acts as a 5-ht1a receptor partial agonist, 5-ht2a, 5-ht2c, and 5-ht7 receptor inverse agonist, and d2, d4, and α1-adrenergic receptor antagonist. binding profile receptorki (nm) 5-ht2a0.06 5-ht2c9.73 5-ht6950 5-ht70.64 m1630 m2180 m31290 m4480 m53900 d20.5 d413.6