fospropofol fospropofol fospropofol (inn), often used as the disodium salt (trade name lusedra) is an intravenous sedative-hypnotic agent. it is currently approved for use in sedation of adult patients undergoing diagnostic or therapeutic procedures such as endoscopy. fospropofolclinical dataahfs/drugs.commonographlicense data us fda: fospropofol pregnancycategory b dependenceliabilityunknownroutes ofadministrationintravenousatc coden01 legal statuslegal status us: schedule iv pharmacokinetic dataprotein binding98%metabolismhepatic glucuronidationelimination half-life0.81 hoursexcretionrenalidentifiers iupac name disodium methyl phosphate cas number258516-89-1 y 258516-87-9 (disodium salt)pubchem cid3038498drugbankdb06716 nchemspider2302062 nuniilz257rzp7kkeggd04257 ychemblchembl1201766 ncomptox dashboard (epa)dtxsid50870295 chemical and physical dataformulac13h21o5pmolar mass288.280 g·mol−13d model (jsmol)interactive image smiles cc(c)c1cccc(c1ocop(=o)(o)o)c(c)c inchi inchi=1s/c13h21o5p/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10h,8h2,1-4h3,(h2,14,15,16) nkey:qvnnonofasoxqv-uhfffaoysa-n n ny (what is this?) (verify) clinical applications several water-soluble derivatives and prodrugs of the widely used intravenous anesthetic agent propofol have been developed, of which fospropofol has been found to be the most suitable for clinical development thus far. purported advantages of this water-soluble chemical compound include less pain at the site of intravenous administration, less potential for hyperlipidemia with long-term administration, and less chance for bacteremia. often, fospropofol is administered in conjunction with an opioid such as fentanyl. clinical pharmacology mechanism of action fospropofol is a prodrug of propofol; it is metabolized by alkaline phosphatases to an active metabolite, propofol. pharmacokinetics initial trial results on fospropofol pharmacokinetics were retracted by the investigators. as of 2011, new results were not available. controlled substance fospropofol is classified as a schedule iv controlled substance in the united states' controlled substances act.