glucuronide glucuronide a glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond. the glucuronides belong to the glycosides. morphine-6-glucuronide, a major metabolite of morphine glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys. enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases. examples miquelianin (quercetin 3-o-glucuronide) morphine-6-glucuronide scutellarein-7-glucuronide