harrison's principles of internal medicine harrison's principles of internal medicine harrison's principles of internal medicine is an american textbook of internal medicine. first published in 1950, it is in its 21st edition (published in 2022 by mcgraw-hill professional isbn 978-1264268504) and comes in two volumes. although it is aimed at all members of the medical profession, it is mainly used by internists and junior doctors in this field, as well as medical students. it is widely regarded as one of the most authoritative books on internal medicine and has been described as the "most recognized book in all of medicine." spanish copy of harrison's principles of internal medicine in its 19th edition. harrison's principles of internal medicine in italian the work is named after tinsley r. harrison of birmingham, alabama, who served as editor-in-chief of the first five editions and established the format of the work: a strong basis of clinical medicine interwoven with an understanding of pathophysiology. history it was published in 1950 by blakiston. creator and editor tinsley harrison's quotation appeared on the first edition of this book in 1950: no greater opportunity or obligation can fall the lot of a human being than to be a physician. in the care of suffering he needs technical skill, scientific knowledge and human understanding. he who uses these with courage, humility and wisdom will provide a unique service to his fellow man and will build an enduring edifice of character within himself. the physician should ask of his destiny no more than this and he should be content with no less. blakiston was acquired by mcgraw-hill in 1954. the 17th edition of the textbook is dedicated to george w. thorn, who was editor of the first seven editions of the book and editor in chief of the eighth edition. he died in 2004. the 18th edition of the book (isbn 978-0071748896) was edited by anthony fauci, dennis kasper, stephen hauser, j. larry jameson and joseph loscalzo. new chapters added include "systems biology in health and disease," "the human microbiome," "the biology of aging," and "neuropsychiatric illnesses in war veterans." the 19th edition of the book was edited by dennis kasper, anthony fauci, stephen hauser, dan longo, j. larry jameson and joseph loscalzo. al.com in december 2014 wrote that it was still "a best-selling internal medicine text in the united states and around the world," and that it had been reprinted 16 times and translated into 14 languages. the 20th edition of the book, edited by dennis kasper, anthony fauci, stephen hauser, dan longo, j. larry jameson and joseph loscalzo, was released on 17 august 2018. the 21st edition of the book was released on 28 march 2022. contents table of contents (20th edition) part 1: the profession of medicine chapter 1: the practice of medicine chapter 2: promoting good health chapter 3: decision-making in clinical medicine chapter 4: screening and prevention of disease chapter 5: health care systems in developed countries chapter 6: the safety and quality of health care chapter 7: racial and ethnic disparities in health care chapter 8: ethical issues in clinical medicine chapter 9: palliative and end-of-life care part 2: cardinal manifestations and presentation of diseases section 1: pain chapter 10: pain: pathophysiology and management chapter 11: chest discomfort chapter 12: abdominal pain chapter 13: headache chapter 14: back and neck pain section 2: alterations in body temperature chapter 15: fever chapter 16: fever and rash chapter 17: fever of unknown origin section 3: nervous system dysfunction chapter 18: syncope (medicine) chapter 19: dizziness and vertigo chapter 20: fatigue chapter 21: neurologic causes of weakness and paralysis chapter 22: numbness, tingling, and sensory loss chapter 23: gait disorders, imbalance, and falls chapter 24: confusion and delirium chapter 25: dementia chapter 26: aphasia, memory loss, hemispatial neglect, frontal syndromes, and other cerebral disorders chapter 27: sleep disorders section 4: disorders of eyes, ears, nose, and throat chapter 28: disorders of the eye chapter 29: disorders of smell and taste chapter 30: disorders of hearing chapter 31: sore throat, earache, and upper respiratory symptoms chapter 32: oral manifestations of disease section 5: alterations in circulatory and respiratory functions chapter 33: dyspnea chapter 34: cough chapter 35: hemoptysis chapter 36: hypoxia and cyanosis chapter 37: edema chapter 38: approach to the patient with a heart murmur chapter 39: palpitations section 6: alterations in gastrointestinal function chapter 40: dysphagia chapter 41: nausea, vomiting, and indigestion chapter 42: diarrhea and constipation chapter 43: unintentional weight loss chapter 44: gastrointestinal bleeding chapter 45: jaundice chapter 46: abdominal swelling and ascites section 7: alterations in renal and urinary tract function chapter 47: dysuria, bladder pain, and the interstitial cystitis/bladder pain syndrome chapter 48: azotemia and urinary abnormalities chapter 49: fluid and electrolyte disturbances chapter 50: hypercalcemia and hypocalcemia chapter 51: acidosis and alkalosis section 8: alterations in the skin chapter 52: approach to the patient with a skin disorder chapter 53: eczema, psoriasis, cutaneous infections, acne, and other common skin disorders chapter 54: skin manifestations of internal disease chapter 55: immunologically mediated skin diseases chapter 56: cutaneous drug reactions chapter 57: photosensitivity and other reactions to light section 9: hematologic alterations chapter 58: interpreting peripheral blood smears chapter 59: anemia and polycythemia chapter 60: disorders of granulocytes and monocytes chapter 61: bleeding and thrombosis chapter 62: enlargement of lymph nodes and spleen part 3: pharmacology chapter 63: principles of clinical pharmacology chapter 64: pharmacogenomics part 4: oncology and hematology section 1: neoplastic disorders chapter 65: approach to the patient with cancer chapter 66: prevention and early detection of cancer chapter 67: cancer genetics chapter 68: cancer cell biology chapter 69: principles of cancer treatment chapter 70: infections in patients with cancer chapter 71: oncologic emergencies chapter 72: cancer of the skin chapter 73: head and neck cancer chapter 74: neoplasms of the lung chapter 75: breast cancer chapter 76: upper gastrointestinal tract cancers chapter 77: lower gastrointestinal cancers chapter 78: tumors of the liver and biliary tree chapter 79: pancreatic cancer chapter 80: neuroendocrine tumors of the gastrointestinal tract and pancreas chapter 81: renal cell carcinoma chapter 82: cancer of the bladder and urinary tract chapter 83: benign and malignant diseases of the prostate chapter 84: testicular cancer chapter 85: gynecologic malignancies chapter 86: primary and metastatic tumors of the nervous system chapter 87: soft tissue and bone sarcomas and bone metastases chapter 88: carcinoma of unknown primary chapter 89: paraneoplastic syndromes: endocrinologic/hematologic chapter 90: paraneoplastic neurologic syndromes and autoimmune encephalitis chapter 91: late consequences of cancer and its treatment section 2: hematopoietic disorders chapter 92: hematopoietic stem cells chapter 93: iron deficiency and other hypoproliferative anemias chapter 94: disorders of hemoglobin chapter 95: megaloblastic anemias chapter 96: hemolytic anemias chapter 97: anemia due to acute blood loss chapter 98: bone marrow failure syndromes including aplastic anemia and myelodysplasia chapter 99: polycythemia vera and other myeloproliferative neoplasms chapter 100: acute myeloid leukemia chapter 101: chronic myeloid leukemia chapter 102: acute lymphoid leukemia chapter 103: chronic lymphocytic leukemia chapter 104: non-hodgkin’s lymphoma chapter 105: hodgkin’s lymphoma chapter 106: less common hematologic malignancies chapter 107: plasma cell disorders chapter 108: amyloidosis chapter 109: transfusion biology and therapy chapter 110: hematopoietic cell transplantation section 3: disorders of hemostasis chapter 111: disorders of platelets and vessel wall chapter 112: coagulation disorders chapter 113: arterial and venous thrombosis chapter 114: antiplatelet, anticoagulant, and fibrinolytic drugs part 5: infectious diseases section 1: basic considerations in infectious diseases chapter 115: approach to the patient with an infectious disease chapter 116: molecular mechanisms of microbial pathogenesis chapter 117: approach to the acutely ill infected febrile patient chapter 118: immunization principles and vaccine use chapter 119: health recommendations for international travel chapter 120: climate change and infectious disease section 2: clinical syndromes: community-acquired infections chapter 121: pneumonia chapter 122: lung abscess chapter 123: infective endocarditis chapter 124: infections of the skin, muscles, and soft tissues chapter 125: infectious arthritis chapter 126: osteomyelitis chapter 127: intraabdominal infections and abscesses chapter 128: acute infectious diarrheal diseases and bacterial food poisoning chapter 129: clostridium difficile infection, including pseudomembranous colitis chapter 130: urinary tract infections, pyelonephritis, and prostatitis chapter 131: sexually transmitted infections: overview and clinical approach chapter 132: encephalitis chapter 133: acute meningitis chapter 134: chronic and recurrent meningitis chapter 135: brain abscess and empyema chapter 136: infectious complications of bites section 3: clinical syndromes: health care-associated infections chapter 137: infections acquired in health care facilities chapter 138: infections in transplant recipients section 4: therapy for bacterial diseases chapter 139: treatment and prophylaxis of bacterial infections chapter 140: bacterial resistance to antimicrobial agents section 5: diseases caused by gram-positive bacteria chapter 141: pneumococcal infections chapter 142: staphylococcal infections chapter 143: streptococcal infections chapter 144: enterococcal infections chapter 145: diphtheria and other corynebacterial infections chapter 146: listeria monocytogenes infections chapter 147: tetanus chapter 148: botulism chapter 149: gas gangrene and other clostridial infections section 6: diseases caused by gram-negative bacteria chapter 150: meningococcal infections chapter 151: gonococcal infections chapter 152: haemophilus and moraxella infections chapter 153: infections due to the hacek group and miscellaneous gram-negative bacteria chapter 154: legionella infections chapter 155: pertussis and other bordetella infections chapter 156: diseases caused by gram-negative enteric bacilli chapter 157: acinetobacter infections chapter 158: helicobacter pylori infections chapter 159: infections due to pseudomonas, burkholderia, and stenotrophomonas species chapter 160: salmonellosis chapter 161: shigellosis chapter 162: infections due to campylobacter and related organisms chapter 163: cholera and other vibrioses chapter 164: brucellosis chapter 165: tularemia chapter 166: plague and other yersinia infections chapter 167: bartonella infections, including cat-scratch disease chapter 168: donovanosis section 7: miscellaneous bacterial infections chapter 169: nocardiosis chapter 170: actinomycosis chapter 171: whipple’s disease chapter 172: infections due to mixed anaerobic organisms section 8: mycobacterial diseases chapter 173: tuberculosis chapter 174: leprosy chapter 175: nontuberculous mycobacterial infections chapter 176: antimycobacterial agents section 9: spirochetal diseases chapter 177: syphilis chapter 178: endemic treponematoses chapter 179: leptospirosis chapter 180: relapsing fever chapter 181: lyme borreliosis section 10: diseases caused by rickettsiae, mycoplasmas, and chlamydiae chapter 182: rickettsial diseases chapter 183: infections due to mycoplasmas chapter 184: chlamydial infections section 11: viral diseases: general considerations chapter 185: medical virology chapter 186: antiviral chemotherapy, excluding antiretroviral drugs section 12: infections due to dna viruses chapter 187: herpes simplex virus infections chapter 188: varicella-zoster virus infections chapter 189: epstein-barr virus infections, including infectious mononucleosis chapter 190: cytomegalovirus and human herpesvirus types 6, 7, and 8 chapter 191: molluscum contagiosum, monkeypox, and other poxvirus infections chapter 192: parvovirus infections chapter 193: human papillomavirus infections section 13: infections due to dna and rna respiratory viruses chapter 194: common viral respiratory infections chapter 195: influenza section 14: infections due to human immunodeficiency virus and other human retroviruses chapter 196: the human retroviruses chapter 197: human immunodeficiency virus disease: aids and related disorders section 15: infections due to rna viruses chapter 198: viral gastroenteritis chapter 199: enterovirus, parechovirus, and reovirus infections chapter 200: measles (rubeola) chapter 201: rubella (german measles) chapter 202: mumps chapter 203: rabies and other rhabdovirus infections chapter 204: arthropod-borne and rodent-borne virus infections chapter 205: ebolavirus and marburgvirus infections section 16: fungal infections chapter 206: diagnosis and treatment of fungal infections chapter 207: histoplasmosis chapter 208: coccidioidomycosis chapter 209: blastomycosis chapter 210: cryptococcosis chapter 211: candidiasis chapter 211 digital extra: candida auris: an emerging multidrug-resistant candida species chapter 212: aspergillosis chapter 213: mucormycosis chapter 214: superficial mycoses and less common systemic mycoses chapter 215: pneumocystis infections section 17: protozoal and helminthic infections: general considerations chapter 216: introduction to parasitic infections chapter 217: agents used to treat parasitic infections section 18: protozoal infections chapter 218: amebiasis and infection with free-living amebae chapter 219: malaria chapter 220: babesiosis chapter 221: leishmaniasis chapter 222: chagas disease and african trypanosomiasis chapter 223: toxoplasma infections chapter 224: protozoal intestinal infections and trichomoniasis section 19: helminthic infections chapter 225: introduction to helminthic infections chapter 226: trichinellosis and other tissue nematode infections chapter 227: intestinal nematode infections chapter 228: filarial and related infections chapter 229: schistosomiasis and other trematode infections chapter 230: cestode infections part 6: disorders of the cardiovascular system section 1: introduction to cardiovascular disorders chapter 231: approach to the patient with possible cardiovascular disease chapter 232: basic biology of the cardiovascular system chapter 233: epidemiology of cardiovascular disease section 2: diagnosis of cardiovascular disorders