8-hydroxyamoxapine 8-hydroxyamoxapine 8-hydroxyamoxapine is an active metabolite of the antidepressant drug amoxapine (asendin). it contributes to amoxapine's pharmacology. it is a serotonin-norepinephrine reuptake inhibitor (snri) with similar norepinephrine, but more serotonin, reuptake inhibition as its parent compound. it plays a part in balancing amoxapine's ratio of serotonin to norepinephrine transporter blockage. 8-hydroxyamoxapinepharmacokinetic dataelimination half-life30 hoursidentifiers iupac name 8-chloro-6-piperazin-1-ylbenzobenzoxazepin-3-ol cas number61443-78-5pubchem cid43656chemspider39784unii0d4t741i48chebichebi:143289comptox dashboard (epa)dtxsid40210388chemical and physical dataformulac17h16cln3o2molar mass329.78 g·mol−13d model (jsmol)interactive image smiles c1cn(ccn1)c2=nc3=c(c=cc(=c3)o)oc4=c2c=c(c=c4)cl inchi inchi=1s/c17h16cln3o2/c18-11-1-3-15-13(9-11)17(21-7-5-19-6-8-21)20-14-10-12(22)2-4-16(14)23-15/h1-4,9-10,19,22h,5-8h2key:qdwnokxuztyvgo-uhfffaoysa-n