anistreplase anistreplase anistreplase is a thrombolytic drug. it is also known as anisoylated plasminogen streptokinase activator complex (apsac). as a thrombolytic drug, it is used to treat blood clots in emergency situations. anistreplaseclinical datatrade nameseminaseahfs/drugs.commicromedex detailed consumer informationatc codeb01ad03 (who) pharmacokinetic dataelimination half-life90 minutesidentifierscas number81669-57-0 ydrugbankdb00029 ychemspidernoneunii5o8v541hj6keggd02947 ychemical and physical datamolar massapprox. 131 kg/mol (verify) uses anistreplase is used to treat blood clots in emergency situations such as myocardial infarction. early treatment gives better outcomes. mechanism of action anistreplase is a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme's active site. when the drug is administered, the acyl group gets hydrolyzed, thereby freeing the activator complex. it converts plasminogen to plasmin, which in turn degrades fibrin (blood clots) to fibrin split products. history anistreplase has been developed by beecham under the brand name eminase. it is also known as anisoylated plasminogen streptokinase activator complex (apsac) after its components.