dermatopathic lymphadenopathy dermatopathic lymphadenopathy in pathology, dermatopathic lymphadenopathy, is lymph node pathology due to skin disease. dermatopathic lymphadenopathyother namesdermatopathic lymphadenitismicrograph showing dermatopathic lymphadenopathy with the characteristic paracortical histiocytosis and melanin-laden macrophages. h&e stain.specialtydermatology cause also known as lipomelanotic reticulosis or pautrier-woringer disease, represents a rare form of benign lymphatic hyperplasia associated with most exfoliative or eczematoid inflammatory erythrodermas, including pemphigus, psoriasis, eczema, neurodermatitis, and atrophia senilis. diagnosis dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy. it has a characteristic pattern of histomorphology and immunohistochemical staining: paracortical histiocytosis melanin-laden macrophages eosinophils plasma cells (medulla of lymph node) differential diagnosis cutaneous t cell lymphoma hodgkin's lymphoma melanoma treatment the treatment is based on the underlying cause.