tautomycin tautomycin tautomycin is a chemical that occurs naturally in shellfish and is produced by the bacterium streptomyces spiroverticillatus. it is a polyketide-based structure characterized by a three hydroxyl groups, two ketones, a dialkylmaleic anhydride, an ester linkage (connecting anhydride unit to polyketide chain), a spiroketal and one methyl ether among others. tautomycin names preferred iupac name (3r,4r,5r,8s,9s,12r)-12--5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl (3r)-3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoate identifiers cas number 109946-35-2 n 3d model (jsmol) interactive image chebi chebi:9414 chembl chembl505512 y chemspider 389529 y echa infocard 100.149.857 ec number 620-961-5 kegg c05372 pubchem cid 440646 comptox dashboard (epa) dtxsid10894179 inchi inchi=1s/c41h66o13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46h,11-20h2,1-10h3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1 ykey: rfcwhqnncojytr-ircaepkssa-n yinchi=1s/c41h66o13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46h,11-20h2,1-10h3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1inchi=1s/c41h66o13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46h,11-20h2,1-10h3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1key: rfcwhqnncojytr-ircaepkssa-n smiles o=c\1oc(=o)/c(=c/1c)(o)cc(=o)o(c(c)c)(oc)(o)cc(=o)(c)(o)cc(3o2(o((c)cc2)cc(c(=o)c)c)cc3c)c properties chemical formula c41h66o13 molar mass 766.966 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). y verify (what is yn ?) infobox references pharmacology it is a very potent inhibitor of the protein phosphatases pp1 and pp2a. tautomycin demonstrates a slight preference for pp1 inhibition relative to pp2a inhibition. tautomycin is closely related to another anhydride containing polyketide pp inhibitor called tautomycetin which, in addition to being useful as a lead for cancer drug discovery, also is a very potent immunosuppressor. the mechanism of immunosuppression by tautomycetin differs from that of more classical immunosuppressors such as rapamycin and tacrolimus.