alglucerase alglucerase alglucerase was a biopharmaceutical drug for the treatment of gaucher's disease. it was a modified form of human β-glucocerebrosidase enzyme, where the non-reducing ends of the oligosaccharide chains have been terminated with mannose residues. algluceraseclinical dataahfs/drugs.commonographmedlineplusa692001atc codea16ab01 (who) pharmacokinetic dataelimination half-life3.6–10.4 minidentifiers iupac name human beta-glucocerebrosidase cas number143003-46-7 ydrugbankdb00088 ychemspidernoneunii27t56c7kk0keggd09675 ychemblchembl1201633 nchemical and physical dataformulac2532h3854n672o711s16molar mass55597.64 g·mol−1 ny (what is this?) (verify) ceredase is the trade name of a citrate buffered solution of alglucerase that was manufactured by genzyme corporation from human placental tissue. it is given intravenously in the treatment of type 1 gaucher's disease. this was the first drug approved as an enzyme replacement therapy. it was approved by the fda in 1991. it has been withdrawn from the market due to the approval of similar drugs made with recombinant dna technology instead of being harvested from tissue; drugs made recombinantly, since there is no concern about diseases being transmitted from the tissue used in harvesting, and are less expensive to manufacture (see imiglucerase).