clomestrone clomestrone clomestrone (brand names arterolo, atheran, colesterel, iposclerone, liprotene, persclerol, others; former developmental code name sc-8246), also known as 16α-chloroestrone 3-methyl ether, is a synthetic, steroidal, weak estrogen derived from estrone and used as an anticholesterolemic agent in the treatment of atherosclerosis. it is said to have beneficial effects on serum lipid profiles while producing minimal feminization, though some estrogenic side effects, including breast tenderness, loss of libido, and fatigue or avolition, were observed in most patients in clinical studies. the drug is a close analogue of mytatrienediol, and the two estrogens have similar drug profiles. clomestrone was described in the literature in 1958 and introduced for medical use shortly thereafter. not to be confused with clometerone. clomestroneclinical datatrade namesarterolo, atheran, colesterel, iposclerone, liprotene, persclerolother namessc-8246; 16α-chloroestrone 3-methyl ether; 16α-chloro-3-methoxyestra-1,3,5(10)-trien-17-oneroutes ofadministrationby mouthdrug classestrogen; estrogen etheridentifiers iupac name (8r,9s,13s,14s,16r)-16-chloro-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopentaphenanthren-17-one cas number4091-75-2pubchem cid107501chemspider96732uniip1l5f7667lcomptox dashboard (epa)dtxsid50878418 echa infocard100.021.669 chemical and physical dataformulac19h23clo2molar mass318.84 g·mol−13d model (jsmol)interactive image smiles cc12ccc3c(c1cc(c2=o)cl)ccc4=c3c=cc(=c4)oc inchi inchi=1s/c19h23clo2/c1-19-8-7-14-13-6-4-12(22-2)9-11(13)3-5-15(14)16(19)10-17(20)18(19)21/h4,6,9,14-17h,3,5,7-8,10h2,1-2h3/t14-,15-,16+,17-,19+/m1/s1key:uqipvsbpfzswgd-ilyvxuqdsa-n