chondroid syringoma chondroid syringoma a chondroid syringoma is a well circumscribed but unencapsulated, multilobulated sweat gland-derived tumor. it is centered in the deep dermis or subcutaneous fat. microscopically it is a mixed tumor, characterized by prominent chondroid or myxoid stroma enveloping benign bland appearing epithelial and myoepithelial cells. its malignant counterpart is malignant chondroid syringoma. histopathology of chondroid syringoma