limestone canyon virus limestone canyon virus limestone canyon virus (lsc) is a single-stranded, negative-sense rna zoonotic orthohantavirus that is genetically similar to sin nombre orthohantavirus which causes hantavirus pulmonary syndrome (hps) in humans. hps causing hantaviruses are found only in the united states and south america. limestone canyon virus virus classification (unranked): virus realm: riboviria kingdom: orthornavirae phylum: negarnaviricota class: ellioviricetes order: bunyavirales family: hantaviridae genus: orthohantavirus (?) virus: limestone canyon virus lsc has not been shown to cause hps in humans. reservoir the virus was isolated from the brush mouse (peromyscus boylii). phylogenetic analysis of m genome segment showed lsc to be very distinct from other peromyscus-borne viruses. other peromyscus-associated hantaviruses include sin nombre orthohantavirus (snv), new york orthohantavirus (nyv), and monongahela virus (mglv).