magaldrate magaldrate magaldrate (inn) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux. magaldrate [ al 3 + ] [ mg 2 + ] 2 [ ho − ] 7 [ h 2 o ] clinical dataahfs/drugs.commicromedex detailed consumer informationmedlineplusa682683pregnancycategory c routes ofadministrationoralatc codea02ad02 (who) a02af01 (who) (combination with antiflatulents)legal statuslegal status in general: over-the-counter (otc) pharmacokinetic databioavailabilitynegligiblemetabolismnilexcretionfecal and renalidentifiers iupac name magnesium aluminate monohydrate cas number74978-16-8 ypubchem cid6336542chemspider4891688 yunii6v88e24n5tcomptox dashboard (epa)dtxsid00157184 echa infocard100.115.465 chemical and physical dataformulaalmg2(oh)7·h2omolar mass212.66 g/mol inchi inchi=1s/al.mg.2h2o/h;;2*1h2/p-1 ykey:sxstvpxrzqqbkq-uhfffaoysa-m y (verify) development magaldrat was first synthesized by the german chemist gunther hallmann and patented on february 2, 1960, by byk gulden lomberg chemische fabrik (germany). in 1983, the active substance was registered as the original drug riopan. available forms magaldrate is available in the form of oral suspension or tablets. pharmacology magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly by gastric acid into mg(oh)2 and al(oh)3, which are absorbed poorly and thus provide a sustained antacid effect. interactions and adverse reactions magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. high doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. in some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.