amylmetacresol amylmetacresol amylmetacresol (amc) is an antiseptic used to treat infections of the mouth and throat. it is used as an active pharmaceutical ingredient in strepsils, cēpacol, gorpils and lorsept throat lozenges, typically in combination with dichlorobenzyl alcohol, another antiseptic. amylmetacresolclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationby mouth (throat lozenges)atc codenonelegal statuslegal status in general: over-the-counter (otc) pharmacokinetic datametabolismoxidation, glucuronidationexcretionvia kidneysidentifiers iupac name 5-methyl-2-pentylphenol cas number1300-94-3 ypubchem cid14759drugbankdb13908chemspider14076 yunii05w904p57fchemblchembl1512677comptox dashboard (epa)dtxsid8046791 echa infocard100.013.722 chemical and physical dataformulac12h18omolar mass178.27 g·mol−13d model (jsmol)interactive imagemelting point24 °c (75 °f) smiles cccccc1=c(c=c(c=c1)c)o inchi inchi=1s/c12h18o/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13h,3-6h2,1-2h3 ykey:ckgwfzqgeqjzil-uhfffaoysa-n y (verify) medical uses the lozenges are used to treat sore throat and minor mouth and throat infections including pharyngitis and gingivitis. a 2017 meta-analysis found that the combination of amc with dichlorobenzyl alcohol has a modest advantage over un-medicated lozenges regarding pain relief. contraindications no contraindications are known apart from hypersensitivity to the substance. adverse effects amylmetacresol sometimes causes soreness of the tongue. hypersensitivity reactions are very rare and show symptoms such as nausea or dyspepsia, although it is not entirely clear which side effects are caused by amc and which by dichlorobenzyl alcohol or other ingredients of the lozenges. amc has a low toxicity with an ld50 of 1500 mg/kg body weight (in rats). overdose no cases of overdosing have been reported. it is not expected to cause symptoms other than gastrointestinal discomfort. interactions no interactions with other drugs are known. pharmacology mechanism of action amylmetacresol is an antibacterial and antiviral substance. it also blocks sodium channels in a manner similar to local anaesthetics. it has a rideal-walker coefficient of 250. pharmacokinetics the substance is rapidly absorbed. it is oxidised to a carboxylic acid, glucuronidated, and quickly eliminated via the kidneys. chemistry amc is a derivative of m-cresol, with a pentyl group attached to the sixth carbon atom. the pure substance melts at 24 °c (75 °f), and boils between 137 and 139 °c (279 and 282 °f) at a pressure of 6.7 kilopascals (50 mmhg). it is soluble in water, ethanol, acetone, diethylether, and oil.