jwh-307 jwh-307 jwh-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the cb1 and cb2 receptors. it is somewhat selective for the cb2 subtype, with a ki of 7.7 nm at cb1 vs 3.3 nm at cb2. it was discovered by, and named after, john w. huffman. jwh-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in germany. jwh-307legal statuslegal status de: anlage ii (authorized trade only, not prescriptible) us: schedule i identifiers iupac name (5-(2-fluorophenyl)-1-pentylpyrrol-3-yl)-naphthalen-1-ylmethanone cas number914458-26-7 ypubchem cid16049783chemspider13178178unii06qtr14onwcomptox dashboard (epa)dtxsid60581542 chemical and physical dataformulac26h24fnomolar mass385.482 g·mol−13d model (jsmol)interactive image smiles cccccn1c=c(c=c1c2=cc=cc=c2f)c(=o)c3=cc=cc4=cc=cc=c43 inchi inchi=1s/c26h24fno/c1-2-3-8-16-28-18-20(17-25(28)23-13-6-7-15-24(23)27)26(29)22-14-9-11-19-10-4-5-12-21(19)22/h4-7,9-15,17-18h,2-3,8,16h2,1h3key:wynzpddtqgvclz-uhfffaoysa-n (verify) in the united states, cb1 receptor agonists of the 3-(1-naphthoyl)pyrrole class such as jwh-307 are schedule i controlled substances.