thyroid-stimulating hormone thyroid-stimulating hormone thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated tsh) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (t4), and then triiodothyronine (t3) which stimulates the metabolism of almost every tissue in the body. it is a glycoprotein hormone produced by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid. thyroid-stimulating hormone, alphaidentifierssymbolcgaalt. symbolshcg, gpha, gpha1ncbi gene1081hgnc1885omim118850refseqnm_000735uniprotp01215other datalocuschr. 6 q14-q21search forstructuresswiss-modeldomainsinterpro thyroid-stimulating hormone, betaidentifierssymboltshbncbi gene7252hgnc12372omim188540refseqnm_000549uniprotp01222other datalocuschr. 1 p13search forstructuresswiss-modeldomainsinterpro physiology the system of the thyroid hormones t3 and t4. hormone levels