sampaolesi line sampaolesi line sampaolesi line is a sign which may be observed during a clinical eye examination. during gonioscopy (where the structures of the eye's anterior segment are examined), if an abundance of brown pigment is seen at or anterior to schwalbe's line, a sampaolesi line is said to be present. the presence of a sampaolesi line can signify pigment dispersion syndrome or pseudoexfoliation syndrome. gonioscopy is performed during eye examinations, which involves placing a mirrored lens on the patient's cornea in order to visualise the angle of the anterior chamber of the eye. causes idiopathic pigment dispersion syndrome pseudoexfoliation syndrome