eshap eshap eshap is an acronym for relatively intensive chemotherapy regimen that is used for salvage therapy in relapsed or refractory lymphomas and hodgkin's lymphoma. in combination with monoclonal antibody rituximab it is called r-eshap or eshap-r. r-eshap consists of: rituximab, an anti-cd20-directed monoclonal antibody that kills both normal and malignant b-lymphocytes etoposide, an epipodophyllotoxin topoisomerase inhibitor solu-medrol - methylprednisolone, which is a glucocorticoid that can lyse lymphocytes high-dose ara-c - cytarabine platinol - cisplatin, a platinum-based antineoplastic agent, also an alkylating antineoplastic agent. dosing regimen drugdosemodedays rituximab375 mg/m2iv infusionday 0 etoposide40 mg/m2iv infusion over 1 hrdays 1-4 solu-medrol - methylprednisolone500 mgiv bolus over 15 mindays 1-5 high-dose ara-c — cytarabine2000 mg/m2iv infusion over 2 hrsday 5 platinol (cisplatin)25 mg/m2iv continuous infusion over 24 hrsdays 1-4