5-iai 5-iai 5-iodo-2-aminoindane (5-iai) is a drug which acts as a releasing agent of serotonin, norepinephrine, and dopamine. it was developed in the 1990s by a team led by david e. nichols at purdue university. 5-iai fully substitutes for mdma in rodents and is a putative entactogen in humans. unlike related aminoindane derivatives like mdai and mmai, 5-iai causes some serotonergic neurotoxicity in rats, but is substantially less toxic than its corresponding amphetamine homologue pia, with the damage observed barely reaching statistical significance. 5-iaiclinical datapregnancycategory ? routes ofadministrationoral, insufflated, rectalatc codenonelegal statuslegal status de: npsg (industrial and scientific use only) uk: under psychoactive substances act in general: uncontrolled identifiers iupac name 5-iodo-2,3-dihydro-1h-inden-2-amine cas number132367-76-1 npubchem cid131506chemspider116224 yunii7x16e45y1xcomptox dashboard (epa)dtxsid60927643 chemical and physical dataformulac9h10inmolar mass259.090 g·mol−13d model (jsmol)interactive image smiles c2c1cc(n)cc1ccc2i inchi inchi=1s/c9h10in/c10-8-2-1-6-4-9(11)5-7(6)3-8/h1-3,9h,4-5,11h2 ykey:bihpycddpgnwqo-uhfffaoysa-n y ny (what is this?) (verify) legal status sweden's public health agency suggested classifying 5-iai as a hazardous substance, on september 25, 2019.