al-gazali-donnai-mueller syndrome al-gazali-donnai-mueller syndrome al-gazali-donnai-mueller syndrome, also known as hirschsprung's disease, hypoplastic nails, and minor dysmorphic features syndrome is a rare and deadly genetic disorder which is characterized by hirschsprung's disease, nail and distal limb hypoplasia, flat facies, upslanting palpebral fissures, narrow philtrum, high palate, micrognathia and low-set ears. no more new cases have been reported in medical literature since 1988. it is a type of hirschsprung's syndrome. al-gazali-donnai-mueller syndromeother nameshirschsprung's disease, hypoplastic nails, and minor dysmorphic features syndromespecialtymedical geneticssymptomspartial absence of nerves in the intestines, facial dysmorphisms and nail hypoplasiacomplicationsdeathusual onsetbirthdurationlife-long (short life span)causesgenetic mutationpreventionnoneprognosisbadfrequencyvery rare