ketofol ketofol ketofol is a mixture of ketamine and propofol. both drugs are anesthetic agents. it can be mixed with propofol in the same syringe. ketofolcombination ofketaminegeneral anestheticpropofolgeneral anestheticidentifierscas number1228575-05-0 (verify) the combination appears to be safer than propofol by itself when used for procedural sedation and analgesia.