siva1 siva1 apoptosis regulatory protein siva is a protein that in humans is encoded by the siva1 gene. this gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the cd27 antigen, a member of the tumor necrosis factor receptor (tfnr) superfamily. the cd27 antigen cytoplasmic tail binds to the n-terminus of this protein. two alternatively spliced transcript variants encoding distinct proteins have been described. siva1identifiersaliasessiva1, cd27bp, siva, siva-1, siva-2, siva1 apoptosis inducing factorexternal idsomim: 605567 mgi: 1353606 homologene: 4692 genecards: siva1 gene location (human)chr.chromosome 14 (human)band14q32.33start104,753,147 bpend104,768,494 bpgene location (mouse)chr.chromosome 12 (mouse)band12|12 f1start112,611,113 bpend112,615,583 bprna expression patternbgeehumanmouse (ortholog)top expressed inpopliteal arterygastric mucosathoracic aortaascending aortaanterior pituitaryoocyteright coronary arteryright lobe of liverleft coronary arterycanal of the cervixtop expressed inotic placoderenal corpusclemedullary collecting ductcondylefossasecondary oocytesacculeinternal carotid arteryexternal carotid arterypaneth cellmore reference expression databiogpsmore reference expression datagene ontologymolecular function zinc ion binding protein binding metal ion binding virus receptor activity tumor necrosis factor receptor binding cd27 receptor binding cellular component cytoplasm mitochondrion nucleus nucleoplasm intracellular anatomical structure biological process apoptotic process intrinsic apoptotic signaling pathway viral process activation-induced cell death of t cells negative regulation of nf-kappab transcription factor activity positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway extrinsic apoptotic signaling pathway viral entry into host cell sources:amigo / quickgoorthologsspecieshumanmouseentrez1057230954ensemblensg00000184990ensmusg00000064326uniproto15304o54926refseq (mrna)nm_006427nm_021709nm_001161737nm_013929refseq (protein)np_006418np_068355np_001155209np_038957location (ucsc)chr 14: 104.75 – 104.77 mbchr 12: 112.61 – 112.62 mbpubmed searchwikidataview/edit humanview/edit mouse interactions siva1 has been shown to interact with cd27. siva (protein) siva protein is a zinc-containing intracellular ligand of the cd4 receptor that promotes hiv-1 envelope-induced apoptosis in t-lymphoid cells. recent research has demonstrated that siva is a direct transcriptional target for the tumor-suppressors p53 and e2f1.