toripristone toripristone toripristone (inn) (developmental code name ru-40555) is a synthetic, steroidal antiglucocorticoid as well as antiprogestogen which was never marketed. it is reported as a potent and highly selective antagonist of the glucocorticoid receptor (gr) (ki = 2.4 nm), though it also acts as an antagonist of the progesterone receptor (pr). the pharmacological profile of toripristone is said to be very similar to that of mifepristone, except that toripristone does not bind to orosomucoid (α1-acid glycoprotein). the drug has been used to study the hypothalamic-pituitary-adrenal axis and has been used as a radiotracer for the gr. its inn was given in 1990. toripristoneclinical dataother namesru-40555; 17β-hydroxy-11β-phenyl]-17α-(1-propyn-1-yl)estra-4,9-dien-3-oneidentifiers iupac name (8s,11r,13s,14s,17s)-17-hydroxy-13-methyl-11-phenyl]-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopentaphenanthren-3-one cas number91935-26-1pubchem cid3086344chemspider2342997unii711d76p884chemblchembl2105533comptox dashboard (epa)dtxsid50238795 chemical and physical dataformulac31h39no2molar mass457.658 g·mol−13d model (jsmol)interactive image smiles cc#c1(cc21(c(c3=c4ccc(=o)c=c4cc23)c5=cc=c(c=c5)n(c)c(c)c)c)o inchi inchi=1s/c31h39no2/c1-6-16-31(34)17-15-28-26-13-9-22-18-24(33)12-14-25(22)29(26)27(19-30(28,31)4)21-7-10-23(11-8-21)32(5)20(2)3/h7-8,10-11,18,20,26-28,34h,9,12-15,17,19h2,1-5h3/t26-,27+,28-,30-,31-/m0/s1key:loiyxtzqbqvhsf-pabolriosa-n