alvocidib alvocidib alvocidib (inn; also known as flavopiridol) is a flavonoid alkaloid cdk9 kinase inhibitor under clinical development by tolero pharmaceuticals for the treatment of acute myeloid leukemia. it has been studied also for the treatment of arthritis and atherosclerotic plaque formation. the target of alvocidib is the positive transcription elongation factor p-tefb. treatment of cells with alvocidib leads to inhibition of p-tefb and the loss of mrna production. alvocidib names iupac name 2′-chloro-5,7-dihydroxy-8-flavone systematic iupac name 2-(2-chlorophenyl)-5,7-dihydroxy-8--4h-1-benzopyran-4-one other names flavopiridol, hmr 1275, l-868275 identifiers cas number 146426-40-6 n 3d model (jsmol) interactive image chebi chebi:47344 n chembl chembl428690 n chemspider 4450222 y drugbank db03496 y iuphar/bps 5680 kegg d09868 mesh flavopiridol pubchem cid 5287969 unii 45ad6x575g y comptox dashboard (epa) dtxsid20904970 inchi inchi=1s/c21h20clno5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27h,6-7,10h2,1h3/t12-,17+/m0/s1 ykey: biivyfltoxdaov-yvefunnksa-n y smiles clc4ccccc4c=2oc1c(c(o)cc(o)c1c(=o)c=2)3ccn(c)c3o properties chemical formula c21h20clno5 molar mass 401.8402 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references the compound is a synthetic analog of natural product rohitukine which was initially extracted from aphanamixis polystachya (formerly amoora rohituka, hence the name) and later from dysoxylum binectariferum. orphan drug the fda has granted orphan drug designation to alvocidib for the treatment of patients with acute myeloid leukemia.