glycoprotein 130 glycoprotein 130 glycoprotein 130 (also known as gp130, il6st, il6r-beta or cd130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. it forms one subunit of the type i cytokine receptor within the il-6 receptor family. it is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. as with other type i cytokine receptors, gp130 possesses a wsxws amino acid motif that ensures correct protein folding and ligand binding. it interacts with janus kinases to elicit an intracellular signal following receptor interaction with its ligand. structurally, gp130 is composed of five fibronectin type-iii domains and one immunoglobulin-like c2-type (immunoglobulin-like) domain in its extracellular portion. il6stavailable structurespdbortholog search: pdbe rcsb list of pdb id codes1bj8, 1bqu, 1i1r, 1p9m, 1pvh, 3l5h, 3l5i, 3l5j,%%s1bj8, 1bqu, 1i1r, 1p9m, 1pvh, 3l5h, 3l5i, 3l5j, 1n2qidentifiersaliasesil6st, cd130, cdw130, gp130, il-6rb, interleukin 6 signal transducerexternal idsomim: 600694 mgi: 96560 homologene: 1645 genecards: il6st gene location (human)chr.chromosome 5 (human)band5q11.2start55,935,095 bpend55,994,993 bpgene location (mouse)chr.chromosome 13 (mouse)band13 d2.2|13 63.73 cmstart112,600,604 bpend112,646,620 bprna expression patternbgeehumanmouse (ortholog)top expressed inparietal pleuragerminal epitheliumvisceral pleuraseminal vesiculacaput epididymissuperficial temporal arterypericardiumlactiferous ductlower lobe of lungurethratop expressed inuterusright lungright lung lobecarotid bodyurinary bladderankleaortic valvebelly cordsciatic nerveaortamore reference expression databiogpsn/agene ontologymolecular function interleukin-11 binding leukemia inhibitory factor receptor activity ciliary neurotrophic factor receptor binding interleukin-27 receptor activity ciliary neurotrophic factor receptor activity cytokine receptor activity protein homodimerization activity interleukin-6 receptor binding growth factor binding interleukin-11 receptor activity oncostatin-m receptor activity interleukin-6 receptor activity interleukin-6 binding protein binding cytokine binding identical protein binding cellular component extracellular exosome extracellular region integral component of membrane cell body ciliary neurotrophic factor receptor complex membrane neuronal cell body dendrite plasma membrane interleukin-6 receptor complex oncostatin-m receptor complex external side of plasma membrane extracellular space receptor complex biological process regulation of notch signaling pathway positive regulation of cardiac muscle hypertrophy negative regulation of apoptotic process negative regulation of interleukin-6-mediated signaling pathway interleukin-11-mediated signaling pathway response to cytokine oncostatin-m-mediated signaling pathway signal transduction interleukin-27-mediated signaling pathway positive regulation of adaptive immune response ciliary neurotrophic factor-mediated signaling pathway leukemia inhibitory factor signaling pathway viral process positive regulation of t cell proliferation interleukin-6-mediated signaling pathway positive regulation of acute inflammatory response cytokine-mediated signaling pathway positive regulation of astrocyte differentiation positive regulation of osteoblast differentiation glycogen metabolic process positive regulation of vascular endothelial growth factor production positive regulation of cell population proliferation positive regulation of tyrosine phosphorylation of stat protein interleukin-12-mediated signaling pathway interleukin-35-mediated signaling pathway sources:amigo / quickgoorthologsspecieshumanmouseentrez357216195ensemblensg00000134352ensmusg00000021756uniprotp40189q17ra0q00560refseq (mrna)nm_001190981nm_002184nm_175767nm_010560refseq (protein)np_001177910np_002175np_786943np_001351204np_001351205np_001351206np_001351207np_001351208np_002175.2np_001177910.1np_034690location (ucsc)chr 5: 55.94 – 55.99 mbchr 13: 112.6 – 112.65 mbpubmed searchwikidataview/edit humanview/edit mouse characteristics the members of the il-6 receptor family all complex with gp130 for signal transduction. for example, il-6 binds to the il-6 receptor. the complex of these two proteins then associates with gp130. this complex of 3 proteins then homodimerizes to form a hexameric complex which can produce downstream signals. there are many other proteins which associate with gp130, such as cardiotrophin 1 (ct-1), leukemia inhibitory factor (lif), ciliary neurotrophic factor (cntf), oncostatin m (osm), and il-11. there are also several other proteins which have structural similarity to gp130 and contain the wsxws motif and preserved cysteine residues. members of this group include lif-r, osm-r, and g-csf-r. loss of gp130 gp130 is an important part of many different types of signaling complexes. inactivation of gp130 is lethal to mice. homozygous mice who are born show a number of defects including impaired development of the ventricular myocardium. haematopoietic effects included reduced numbers of stem cells in the spleen and liver. signal transduction gp130 has no intrinsic tyrosine kinase activity. instead, it is phosphorylated on tyrosine residues after complexing with other proteins. the phosphorylation leads to association with jak/tyk tyrosine kinases and stat protein transcription factors. in particular, stat-3 is activated which leads to the activation of many downstream genes. other pathways activated include ras and mapk signaling. interactions glycoprotein 130 has been shown to interact with: grb2, her2/neu, janus kinase 1 leukemia inhibitory factor receptor, ptpn11, shc1, socs3, and tle1.