imiglucerase imiglucerase imiglucerase is a medication used in the treatment of gaucher's disease. imigluceraseclinical datatrade namescerezymeahfs/drugs.commonographmedlineplusa601149license data eu ema: by inn us dailymed: imiglucerase routes ofadministrationintravenous infusionatc codea16ab02 (who) legal statuslegal status us: ℞-only eu: rx-only pharmacokinetic datametabolismprobably proteolysiselimination half-life3.6–10.4 minidentifiers iupac name human beta-glucocerebrosidase cas number154248-97-2 ndrugbankdb00053 ychemspidernoneuniiq6u6j48bwykeggd02810 ychemblchembl1201632 nchemical and physical dataformulac2532h3854n672o711s16molar mass55597.4 g·mol−1 (unglycosylated) ny (what is this?) (verify) it is a recombinant dna-produced analogue of the human enzyme β-glucocerebrosidase. cerezyme is a freeze-dried medicine containing imiglucerase, manufactured by genzyme corporation. it is given intravenously after reconstitution as a treatment for type 1 and type 3 gaucher's disease. it is available in formulations containing 200 or 400 units per vial. the specific activity of highly purified human enzyme is 890,000 units/mg, meanwhile the enzyme activity produced by recombinant dna technology is approximately 40 units/mg. a typical dose is 2.5u/kg every two weeks, up to a maximum of 60 u/kg once every two weeks, and safety has been established from ages 2 and up. it is one of more expensive medications, with an annual cost of $200,000 per person in the united states. imiglucerase has been granted orphan drug status in the united states, australia, and japan. cerezyme was one of the drugs manufactured at genzyme's allston, massachusetts plant, for which production was disrupted in 2009 after contamination with vesivirus 2017. side effects the most common side effect is hypersensitivity, which occurs in about 3% of patients. it is associated with symptoms such as cough, shortness of breath, rashes, itching, and angiooedema. less common side effects include dizziness, headache, nausea, diarrhoea, and reactions at the injection site; they are found in less than 1% of patients. interactions no clinical interaction studies have been conducted. miglustat appears to increase the clearance of imiglucerase by 70%, resulting in decreased enzyme activity.