s-18986 s-18986 s-18986 is a positive allosteric modulator of the ampa receptor related to cyclothiazide. it has nootropic and neuroprotective effects in animal studies, and induces both production of bdnf and ampa-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain. s-18986legal statuslegal status us: investigational new drug identifiers iupac name (s)-2,3-dihydro-cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide cas number175340-20-2 ypubchem cid637863iuphar/bps4304chemspider553445 nuniiia262432y9comptox dashboard (epa)dtxsid40938656 chemical and physical dataformulac10h12n2o2smolar mass224.28 g·mol−13d model (jsmol)interactive image smiles c1c2ns(=o)(=o)c3=cc=cc=c3n2c1 inchi inchi=1s/c10h12n2o2s/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11h,3,6-7h2/t10-/m1/s1 nkey:mntijygeitvwhu-snvbaglbsa-n n ny (what is this?) (verify)