pppa (drug) pppa (drug) pppa, or 3-phenoxy-3-phenylpropan-1-amine, is a drug which is described as an antidepressant. it was derived by eli lilly from the antihistamine diphenhydramine, a 2-diphenylmethoxyethanamine derivative with additional properties as a selective serotonin reuptake inhibitor (ssri), and has been the basis for the subsequent discovery of a number of other antidepressant drugs. pppaclinical dataatc codenoneidentifiers iupac name 3-phenoxy-3-phenyl-1-propanamine cas number48166-95-6 ychemspider14379241uniiee55yaq6hnchemical and physical dataformulac15h17nomolar mass227.307 g·mol−13d model (jsmol)interactive image smiles c1ccc(cc1)c(ccn)oc2ccccc2 inchi inchi=1s/c15h17no/c16-12-11-15(13-7-3-1-4-8-13)17-14-9-5-2-6-10-14/h1-10,15h,11-12,16h2key:xywlzhpzecqhmb-uhfffaoysa-n list of pppa derivatives atomoxetine ((3r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine) — nri fluoxetine (n-methyl-3-(4-(trifluoromethyl)phenoxy)-3-phenylpropan-1-amine) — ssri n-methyl-pppa (n-methyl-3-phenoxy-3-phenylpropan-1-amine) — snri nisoxetine (n-methyl-3-(2-methoxyphenoxy)-3-phenylpropan-1-amine) — nri norfluoxetine (3-(4-(trifluoromethyl)phenoxy)-3-phenylpropan-1-amine) — ssri seproxetine ((s)-3-(4-(trifluoromethyl)phenoxy)-3-phenylpropan-1-amine) — ssri structurally related drugs include dapoxetine, duloxetine, edivoxetine, femoxetine, paroxetine, reboxetine, and viloxazine, all of which act, similarly, as monoamine reuptake inhibitors, and most of which are, again similarly, antidepressants. zimelidine is an antidepressant and ssri which was derived from the antihistamine pheniramine, which, similarly to its analogues brompheniramine and chlorpheniramine, possesses snri properties. fluvoxamine, another antidepressant and ssri, was developed from the antihistamine tripelennamine, which possesses sndri actions.