prorenone prorenone prorenone (developmental code name sc-23133) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed. it is the lactonic form of prorenoic acid (prorenoate), and prorenoate potassium (sc-23992), the potassium salt of prorenoic acid, also exists. prorenoate potassium is about 8 times more potent than spironolactone as an antimineralocorticoid in animals, and it may act as a prodrug to prorenone. in addition to the mineralocorticoid receptor, prorenone also binds to the glucocorticoid, androgen, and progesterone receptors. the antiandrogenic potency of prorenone in vivo in animals is close to that of spironolactone. similarly to spironolactone, prorenone is also a potent inhibitor of aldosterone biosynthesis. prorenoneclinical dataother namessc-23133; 3-(17β-hydroxy-6β,7β-methylene-3-oxo-4-androsten-17α-yl)propionic acid γ-lactoneatc codenoneidentifiers iupac name (1as,5ar,5bs,7as,8r,10as,10br,10cs)-5a,7a-dimethyl-1,1a,3',4,4',5,5a,5b,6,7,7a,9,10,10a,10b,10c-hexadecahydro-3h,5'h-spirocyclopropaphenanthrene-8,2'-furan]-3,5'-dione cas number49848-04-6pubchem cid170819iuphar/bps2876chemspider149344comptox dashboard (epa)dtxsid50964446 chemical and physical dataformulac23h30o3molar mass354.490 g·mol−13d model (jsmol)interactive image smiles o=c6o5(3((24(/c1=c/c(=o)cc1(c)2cc3)c4)cc5)c)cc6 inchi inchi=1s/c23h30o3/c1-21-7-3-13(24)11-18(21)14-12-15(14)20-16(21)4-8-22(2)17(20)5-9-23(22)10-6-19(25)26-23/h11,14-17,20h,3-10,12h2,1-2h3/t14-,15+,16-,17-,20+,21+,22-,23+/m0/s1key:rrhhmfqghcfgmh-laplkbaysa-n chemistry synthesis prorenone can be synthesized via a johnson–corey–chaykovsky reaction by reaction of canrenone with trimethylsulfonium iodide and sodium hydride.