adrenorphin adrenorphin adrenorphin, also sometimes referred to as metorphamide, is an endogenous, c-terminally amidated, opioid octapeptide (tyr-gly-gly-phe-met-arg-arg-val-nh2, yggfmrrv-nh2) that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain. it was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors. it possesses analgesic and respiratory depressive properties. adrenorphin names iupac name l-tyrosylglycylglycyl-l-phenylalanyl-l-methionyl-l-arginyl-l-arginyl-l-valinamide identifiers cas number 88377-68-8 n 3d model (jsmol) interactive image chemspider 108968 y pubchem cid 122176 comptox dashboard (epa) dtxsid30237009 inchi inchi=1s/c44h69n15o9s/c1-25(2)36(37(46)63)59-41(67)31(12-8-19-52-44(49)50)57-39(65)30(11-7-18-51-43(47)48)56-40(66)32(17-20-69-3)58-42(68)33(22-26-9-5-4-6-10-26)55-35(62)24-53-34(61)23-54-38(64)29(45)21-27-13-15-28(60)16-14-27/h4-6,9-10,13-16,25,29-33,36,60h,7-8,11-12,17-24,45h2,1-3h3,(h2,46,63)(h,53,61)(h,54,64)(h,55,62)(h,56,66)(h,57,65)(h,58,68)(h,59,67)(h4,47,48,51)(h4,49,50,52)/t29-,30-,31+,32-,33-,36-/m0/s1 ykey: xjoqrtjdyahkpy-yvwimrngsa-n yinchi=1s/c44h69n15o9s/c1-25(2)36(37(46)63)59-41(67)31(12-8-19-52-44(49)50)57-39(65)30(11-7-18-51-43(47)48)56-40(66)32(17-20-69-3)58-42(68)33(22-26-9-5-4-6-10-26)55-35(62)24-53-34(61)23-54-38(64)29(45)21-27-13-15-28(60)16-14-27/h4-6,9-10,13-16,25,29-33,36,60h,7-8,11-12,17-24,45h2,1-3h3,(h2,46,63)(h,53,61)(h,54,64)(h,55,62)(h,56,66)(h,57,65)(h,58,68)(h,59,67)(h4,47,48,51)(h4,49,50,52)/t29-,30-,31+,32-,33-,36-/m0/s1key: xjoqrtjdyahkpy-yvwimrngbtinchi=1/c44h69n15o9s/c1-25(2)36(37(46)63)59-41(67)31(12-8-19-52-44(49)50)57-39(65)30(11-7-18-51-43(47)48)56-40(66)32(17-20-69-3)58-42(68)33(22-26-9-5-4-6-10-26)55-35(62)24-53-34(61)23-54-38(64)29(45)21-27-13-15-28(60)16-14-27/h4-6,9-10,13-16,25,29-33,36,60h,7-8,11-12,17-24,45h2,1-3h3,(h2,46,63)(h,53,61)(h,54,64)(h,55,62)(h,56,66)(h,57,65)(h,58,68)(h,59,67)(h4,47,48,51)(h4,49,50,52)/t29-,30-,31+,32-,33-,36-/m0/s1key: xjoqrtjdyahkpy-yvwimrngbt smiles o=c(n)(nc(=o)(nc(=o)(nc(=o)(nc(=o)(nc(=o)cnc(=o)cnc(=o)(n)cc1ccc(o)cc1)cc2ccccc2)ccsc)ccc/n=c(\n)n)ccc/n=c(\n)n)c(c)c properties chemical formula c44h69n15o9s molar mass 984.18 g/mol except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references