sponge isolates sponge isolates lacking an immune system, protective shell, or mobility, sponges have developed an ability to synthesize a variety of unusual compounds for survival. c-nucleosides isolated from caribbean cryptotethya crypta, were the basis for the synthesis of zidovudine (azt), aciclovir (cyclovir), cytarabine (depocyt), and cytarabine derivative gemcitabine (gemzar). isolate source researched activity / chemical description 3-alkylpyridinium (3-ap) haplosclerida hemolytic and cytotoxic agosterol a anticancer aplyzanzine a aplysina sp. avarol dysidea avara antitumor, antimicrobial and antiviral effects aciculitin aciculites ciliate antifungal cyclic peptide discodermin discodermia kiiensis antimicrobial tetradecapeptide dysidenin lamellodysidea herbacea highly toxic girolline girolline inhibits protein synthesis halichondrin b halichondria okadai kadota (miura peninsula) precursor to eribulin (halaven) halicylindramide halichondria antifungal peptide hymenamides phakellia fusca proline-containing cyclopeptide hymenistatin phakellia fusca bio-active proline-containing cyclopeptide hyrtinadine a hyrtios bio-active bis-indole alkaloid manzamines various sponge species bio-active β-carbolines mirabamide siliquariaspongia mirabilis antiviral depsipeptide neamphamide a neamphius huxleyi antiviral depsipeptide onnamide a theonella swinhoei cytotoxic, inhibits protein synthesis peloruside a mycale sp. (new zealand) cytotoxic / structurally similar to bryostatin phakellistatins phakellia fusca proline-containing cyclopeptides phoriospongin phoriospongia and callyspongia bilamellata nematocidal compound plakevulin a plakortis dna polymerase inhibitor plakoridine a plakortis polydiscamide b ircinia the first example of a nonendogenous human snsr (human sensory neuron-specific g protein couple receptor) agonist ptilomycalin a monanchora arbuscula antifungal spirocyclic guanidine alkaloid / laccase and melanization inhibitor sceptrin agelas conifera antibiotic suberedamine suberea theonellamide f theonella antimicrobial/antifungal cytotoxic bicyclic dodecapeptide topsentolides topsentia cytotoxic oxylipins xestoquinone xestospongia antimalarial, antifungal, and cytotoxic halichondria produces the eribulin (halaven) precursor halichondrin b semisynthetic analogs of the sponge isolate jasplakinolide, were submitted to national cancer institute’s biological evaluation committee in 2011. other marine isolates trabectedin, aplidine, didemnin, were isolated from sea squirts. monomethyl auristatin e is a derivative of a dolastatin 10, a compound made by dolabella auricularia. bryostatins were first isolated from bryozoa. salinosporamides are derived from salinispora tropica. ziconotide is derived from the sea snail conus magus.