functional disorder functional disorder ‘functional disorder’ is an umbrella term for a group of recognisable medical conditions which are due to changes to the functioning of the systems of the body rather than due to a disease affecting the structure of the body. not to be confused with functional medicine. functional disorders are common and complex phenomena that pose challenges to medical systems. traditionally in western medicine, the body is thought of as consisting of different organ systems, but it is less well understood how the systems interconnect or communicate. functional disorders can affect the interplay of several organ systems (for example gastrointestinal, respiratory, musculoskeletal or neurological) leading to multiple and variable symptoms. less commonly there is a single prominent symptom or organ system affected. most symptoms that are caused by structural disease can also be caused by a functional disorder. because of this, individuals often undergo many medical investigations before the diagnosis is clear. though research is growing to support explanatory models of functional disorders, structural scans such as mris, or laboratory investigation such as blood tests do not usually explain the symptoms or the symptom burden. this difficulty in 'seeing' the processes underlying the symptoms of functional disorders has often resulted in these conditions being misunderstood and sometimes stigmatised within medicine and society. despite being associated with high disability, functional symptoms are not a threat to life, and are considered modifiable with appropriate treatment. definition functional disorders are mostly understood as conditions characterised by: persistent and troublesome symptoms associated with impairment or disability where the pathophysiological basis is related to problems with the functioning and communication of the body systems (as opposed to disease affecting the structure of organs or tissues) examples there are many different functional disorder diagnoses that might be given depending on the symptom or syndrome that is most troublesome. there are many examples of symptoms that individuals may experience, some of these include persistent or recurrent pain, fatigue, weakness, shortness of breath or bowel problems. single symptoms may be assigned a diagnostic label, for example “functional chest pain”, “functional constipation” or “functional seizures”. characteristic collections of symptoms might be described as one of the functional somatic syndromes. a syndrome is a collection of symptoms. somatic means ‘of the body’. examples of functional somatic syndromes include; irritable bowel syndrome, cyclic vomiting syndrome, some persistent fatigue and chronic pain syndromes, such as fibromyalgia (chronic widespread pain), or chronic pelvic pain. other examples include interstitial cystitis (urology) and functional neurological disorder (neurology), and multiple chemical sensitivity (allergy medicine). overlap most medical specialties define their own functional somatic syndrome, and a patient may end up with several of these diagnoses without understanding how they are connected. there is overlap in symptoms between all the functional disorder diagnoses. for example, it is not uncommon to have a diagnosis of irritable bowel syndrome (ibs) and chronic widespread pain/fibromyalgia. all functional disorders share risk factors and factors that contribute to their persistence. increasingly researchers and clinicians are recognising the relationships between these syndromes. terminology and classification the terminology for functional disorders has been fraught with confusion and controversy, with many different terms used to describe them. sometimes functional disorders are equated or mistakenly confused with diagnoses like category of “somatoform disorders”, “medically unexplained symptoms”, “psychogenic symptoms” or “conversion disorders”. many historical terms are now no longer thought of as accurate, and are considered by many to be stigmatising. psychiatric illnesses have historically also been considered as functional disorders in some classification systems, as they often fulfil the criteria above. from now on, this article refers primarily to functional somatic disorders in which the primary troubling symptoms are generally understood as related to the body. whether a given medical condition is termed a functional disorder depends in part on the state of knowledge. some diseases, such as epilepsy, were historically categorized as functional disorders but are no longer classified that way. prevalence functional disorders can affect individuals of all ages, ethnic groups and socioeconomic backgrounds. in clinical populations, functional disorders are common and have been found to present in around one-third of consultations in both specialist practice and primary care. chronic courses of disorders are common and are associated with high disability, health-care usage and social costs. rates differ in the clinical population compared with the general population, and will vary depending on the criteria used to make the diagnosis. for example, irritable bowel syndrome is thought to affect 4.1%, and fibromyalgia 0.2-11.4% of the global population. a recent large study carried out on population samples in denmark showed the following: in total, 16.3% of adults reported symptoms fulfilling the criteria for at least one functional somatic syndrome, and 16.1% fulfilled criteria for bodily distress syndrome. diagnosis the diagnosis of the functional disorder(s) is usually made in the healthcare setting most often by a doctor - this could be a primary care physician or family doctor, hospital physician or specialist in the area of psychosomatic medicine or a consultant-liaison psychiatrist. the primary care physician or family doctor will generally play an important role in coordinating treatment with a secondary care clinician if necessary. the diagnosis is essentially clinical, whereby the clinician undertakes a thorough medical and mental health history and physical examination. diagnosis should be based on the nature of the presenting symptoms, and is a “rule in” as opposed to “rule out” diagnosis - this means it is based on the presence of positive symptoms and signs that follow a characteristic pattern. there is usually a process of clinical reasoning to reach this point and assessment might require several visits, ideally with the same doctor. in the clinical setting, there are no laboratory or imaging tests that can consistently be used to diagnose the condition(s); however, as is the case with all diagnoses, often additional diagnostic tests (such as blood tests, or diagnostic imaging) will be undertaken to consider the presence of underlying disease. there are however diagnostic criteria that can be used to help a doctor assess whether an individual is likely to suffer from a particular functional syndrome. these are usually based on the presence or absence of characteristic clinical signs and symptoms. self-report questionnaires may also be used/helpful. there has been a tradition of a separate diagnostic classification systems for 'somatic' and 'mental' disorder classifications. currently, the 11th version of the international classification system of diseases (icd-11) has specific diagnostic criteria for certain disorders which would be considered by many clinicians to be functional somatic disorders, such as ibs or chronic widespread pain/fibromyalgia, and dissociative neurological symptom disorder. in the 5th edition of the diagnostic and statistical manual of mental disorders (dsm-5) the older term “somatoform” (dsm-iv) has been replaced by “somatic symptom disorder”, which is a disorder characterised by persistent somatic (physical) symptom(s ), and associated psychological problems to the degree that it interferes with daily functioning and causes distress. (apa, 2022). bodily distress disorder is a related term in the icd-11. somatic symptom disorder and bodily distress disorder have significant overlap with functional disorders and are often assigned if someone would benefit from psychological therapies addressing psychological or behavioural factors which contribute to the persistence of symptoms. note however that people with symptoms partly explained by structural disease (for example cancer) may also meet the criteria for diagnosis of functional disorders, somatic symptom disorder and bodily distress disorder. it is not unusual for a functional disorder to coexist with another diagnosis (for example functional seizures can coexist with epilepsy, or irritable bowel syndrome with inflammatory bowel disease. this is important to recognise as additional treatment approaches might be indicated in order that the patient achieves adequate relief from their symptoms. the diagnostic process is considered an important step in order for treatment to move forward successfully. when healthcare professionals are giving a diagnosis and carrying out treatment, it is important to communicate openly and honestly and not to fall into the trap of dualistic concepts – that is “either mental or physical” thinking; or attempt to “reattribute” symptoms to a predominantly psychosocial cause. it often important to recognise the need to cease unnecessary additional diagnostic testing if a clear diagnosis has been established . causes explanatory models that support our understanding of functional disorders take into account the multiple factors involved in symptom development. a personalised, tailored approach is usually needed in order to consider the factors which relate to that individual’s biomedical, psychological, social, and material environment. healthcare professionals might find it useful to consider three main categories of factors: predisposing, precipitating, and perpetuating (maintaining) factors. predisposing factors these are factors that make the person more vulnerable to the onset of a functional disorder; and include biological, psychological and social factors. like all health conditions, some people are probably predisposed to develop functional disorders due to their genetic make-up. however, no single genes have been identified that are associated with functional disorders. epigenetic mechanisms (mechanisms that affect interaction of genes with their environment) are likely to be important, and have been studied in relation to the hypothalamic-pituitary-adrenal axis. other predisposing factors include current or prior somatic/physical illness or injury, and endocrine, immunological or microbial factors. functional disorders are diagnosed more frequently in female patients. the reasons for this are complex and multifactorial, likely to include both biological and social factors. female sex hormones might affect the functioning of the immune system for example. medical bias possibly contributes to the sex differences in diagnosis: women are more likely to be diagnosed than men with a functional disorder by doctors. people with functional disorders also have higher rates of pre-existing mental and physical health conditions, including depression and anxiety disorders, post-traumatic stress disorder, multiple sclerosis and epilepsy. personality style has been suggested as a risk factor in the development of functional disorders but the effect of any individual personality trait is variable and weak. alexithymia (difficulties recognising and naming emotions) has been widely studied in patients with functional disorders and is sometimes addressed as part of treatment. migration, cultural and family understanding of illness, are also factors that influence the chance of an individual developing a functional disorder. being exposed to illness in the family when you are growing up or having parents who are healthcare professionals are sometimes considered risk factors. adverse childhood experiences and traumatic experiences of all kinds are known important risk factors. precipitating factors these are the factors that for some patients appear to trigger the onset of a functional disorder. typically, these involve either an acute cause of physical or emotional stress, for example an operation, a viral illness, a car accident, a sudden bereavement, or a period of intense and prolonged overload of chronic stressors (for example relationship difficulties, job or financial stress, or caring responsibilities). not all affected individuals will be able to identify obvious precipitating factors and some functional disorders develop gradually over time. perpetuating factors these are the factors that contribute to the development of functional disorder as a persistent condition and maintaining symptoms. these can include the condition of the physiological systems including the immune and neuroimmune systems, the endocrine system, the musculoskeletal system, the sleep-wake cycle, the brain and nervous system, the person’s thoughts and experience, his/her experience of the body, social situation and environment. all these layers interact with each other. illness mechanisms are important therapeutically as they are seen as potential targets of treatment. the exact illness mechanisms that are responsible for maintaining an individual’s functional disorder should be considered on an individual basis. however, various models have been suggested to account for how symptoms develop and continue. for some people there seems to be a process of central-sensitisation, chronic low grade inflammation or altered stress reactivity mediated through the hypothalamic-pituitary-adrenal (hpa) axis (fischer et al., 2022). for some people attentional mechanisms are likely to be important. commonly, illness-perceptions or behaviours and expectations (henningsen, van den bergh et al. 2018 ) contribute to maintaining an impaired physiological condition. perpetuating illness mechanisms are often conceptualized as ‘vicious cycles’, which highlights the non-linear patterns of causality characteristic of these disorders. other people adopt a pattern of trying to achieve a lot on ‘good days’ which results in exhaustion for days following and a flare up of symptoms, (sometimes called ‘boom-bust’), which has led to various energy management tools being used the patient community such