smokeless tobacco smokeless tobacco smokeless tobacco is a tobacco product that is used by means other than smoking. their use involves chewing, sniffing, or placing the product between gum and the cheek or lip. smokeless tobacco products are produced in various forms, such as chewing tobacco, snuff, snus, and dissolvable tobacco products. smokeless tobacco products typically contain over 3000 constituents. all smokeless tobacco products contain nicotine and are therefore highly addictive. quitting smokeless tobacco use is as challenging as smoking cessation. a historical depiction of a man taking snuff using his thumb and forefinger. smokeless tobacco is much lower on the risk continuum than combusted products but varies in risk within that class of products (e.g., low nitrosamine swedish-type snus versus other smokeless tobacco with high nitrosamine levels). it is estimated the safety risk of smokeless tobacco is similar to that of electronic cigarettes. there is no safe level of smokeless tobacco use. it is correlated with a number of adverse effects such as dental disease, oral cancer, oesophagus cancer, and pancreas cancer, as well as adverse reproductive effects including stillbirth, premature birth and low birth weight. smokeless tobacco products contain cancer-causing chemicals. approximately 28 chemical constituents present in smokeless tobacco are carcinogenic in nature, among which nitrosamine is the most prominent. smokeless tobacco accounts for an abundance of deaths globally with a significant proportion of them attributed to southeast asia. smokeless tobacco consumption is widespread throughout the world. once addicted to nicotine from smokeless tobacco use, many people, particularly young people, expand their tobacco use by smoking cigarettes. males were more likely than females to have used smokeless tobacco in the past month. types dipping tobacco is placed directly in the mouth. most smokeless tobacco use involves placing the product between the gum and the cheek or lip. smokeless tobacco is a noncombustible tobacco product. types of smokeless tobacco include: dipping tobacco, a type of tobacco that is placed between the lower or upper lip and gums chewing tobacco, a type of tobacco that is chewed iqmik, an alaskan tobacco product which also contains punk ash snuff, a type of tobacco that is inhaled or "snuffed" into the nasal cavity snus, similar to dipping tobacco although the tobacco is placed under the upper lip and there is no need for spitting creamy snuff, a fluid tobacco mixture marketed as a dental hygiene aid, albeit used for recreation naswar, an afghan tobacco product similar to dipping tobacco tobacco gum, a kind of chewing gum containing tobacco gutka, a mixture of tobacco, areca nut, and various flavoring sold in south asia dissolvable tobacco, a variation on chewing tobacco that completely dissolves in the mouth toombak and shammah, preparations found in north africa, east africa, and the arabian peninsula topical tobacco paste, a paste applied to the skin and absorbed through the dermis since there are varied manufacturing methods, products can differ greatly in chemical arrangement and nicotine level. smokeless tobacco products typically contain over 3000 constituents which play a part in their taste as well as scent. nicotine levels smokeless tobacco differs depending on the type of product, the types of tobacco used, and the amount of each tobacco type used within a product. each variable results in different level of nicotine. furthermore, nicotine is absorbed by the body to different degrees depending on the ph level of the product, which is known as the free nicotine or unionized nicotine level. below are some measured nicotine levels of various smokeless tobacco products from 2006 and 2007 and their corresponding free nicotine levels as calculated by the henderson–hasselbalch equation. product nicotine (mg/g) free nicotine (mg/g) free nicotine (% of total nicotine) ph type form year ariva3.900.7017.957.36dissolvable, drypieces2007 stonewall natural8.191.1714.237.24dissolvable, drypieces2007 beech-nut chewing tobacco7.070.020.355.56loose leafloose2006 hawken wintergreen2.920.010.225.37loose leafcut2007 lancaster premium chewing tobacco8.010.010.115.05loose leafloose2007 levi garrett chewing tobacco5.340.061.196.10loose leafloose2006 red man chewing tobacco8.580.080.885.97loose leafloose2006 red man golden chewing tobacco7.700.060.725.88loose leafloose2006 stoker chew apple chewing tobacco3.770.010.225.37loose leafloose2007 taylor's pride6.430.060.905.98plugone cut2006 catch dry eucalyptus15.931.398.727.00snuff, drypouch2006 catch dry licorice16.700.684.096.65snuff, drypouch2006 skoal dry11.912.3920.087.42snuff, drypouch2007 taboka16.730.362.146.36snuff, drypouch2007 taboka green13.010.483.666.60snuff, drypouch2007 bruton scotch snuff17.490.492.806.48snuff, drypowder2006 dental sweet snuff11.140.131.196.10snuff, drypowder2006 levi garrett snuff16.600.070.425.65snuff, drypowder2007 railroad mills plain scotch snuff23.130.482.096.35snuff, drypowder2007 red seal sweet snuff15.080.402.626.45snuff, drypowder2007 camel frost13.254.7035.467.76snuff, moistpouch2006 camel frost14.104.7133.397.72snuff, moistpouch2007 camel original13.874.7033.907.73snuff, moistpouch2006 camel original13.496.2045.987.95snuff, moistpouch2007 camel spice13.166.6550.588.03snuff, moistpouch2006 camel spice13.166.6550.588.03snuff, moistpouch2007 cooper long cut wintergreen7.971.0913.687.22snuff, moistlong cut2007 copenhagen12.683.2125.317.55snuff, moistfine cut2006 copenhagen long cut13.915.3838.697.82snuff, moistlong cut2006 copenhagen pouches11.216.8160.778.21snuff, moistfine cut2006 general loose7.151.8726.197.57snuff, moistcoarse2006 general original portion8.465.1060.228.20snuff, moistpouch2006 general white portion7.924.8160.778.21snuff, moistpouch2006 grizzly long cut wintergreen10.296.5964.018.27snuff, moistlong cut2006 grizzly long cut wintergreen11.205.8652.308.06snuff, moistlong cut2007 husky fine cut natural12.864.7737.067.79snuff, moistfine cut2007 kayak long cut wintergreen11.882.2618.997.39snuff, moistlong cut2007 kodiak premium wintergreen10.936.5259.668.19snuff, moistlong cut2006 kodiak premium wintergreen10.708.1876.398.53snuff, moistlong cut2007 longhorn long cut wintergreen13.795.7241.457.87snuff, moistlong cut2007 red seal fine cut natural13.173.1123.617.51snuff, moistfine cut2007 renegades wintergreen13.362.4017.957.36snuff, moistpouch2007 skoal fine cut original13.313.8528.957.63snuff, moistfine cut2006 skoal long cut cherry12.701.6713.157.20snuff, moistlong cut2006 skoal long cut mint12.933.6828.477.62snuff, moistlong cut2006 skoal long cut straight13.373.9429.427.64snuff, moistlong cut2006 skoal long cut wintergreen12.842.8722.387.48snuff, moistlong cut2006 timberwolf long cut wintergreen14.135.1636.537.78snuff, moistlong cut2007 prevalence more than 300 million people are using smokeless tobacco worldwide. people of many regions, including india, pakistan, other asian countries, and north america, have a long history of smokeless tobacco use. once addicted to nicotine from smokeless tobacco use, many people, particularly young people, expand their tobacco use by smoking cigarettes. because young people who use smokeless tobacco can become addicted to nicotine, they may be more likely to also become cigarette smokers. youth are particularly susceptible to starting smokeless tobacco use. males were more likely than females to have used smokeless tobacco in the past month. in 2014, 3.3 percent of people aged 12 or older (an estimated 8.7 million people) used smokeless tobacco in the past month. past month smokeless tobacco use remained relatively stable between 2002 and 2014. past month smokeless tobacco use between 2002 and 2014 was mostly consistent among adults aged 26 or older. there was more variability in the percentages of young adults aged 18 to 25 and adolescents aged 12 to 17 who used smokeless tobacco between 2002 and 2014. smokeless tobacco use for adolescents aged 12 to 17 was higher during the mid-2000s, but the 2014 estimates were closer to the lower levels seen in the early 2000s. in 2014, an estimated 1.0 million people aged 12 or older used smokeless tobacco for the first time in the past year; this represents 0.5 percent of people who had not previously used smokeless tobacco. in 2016 about 2 of every 100 middle school students in the us (2.2%) reported current use of smokeless tobacco. in 2016 nearly 6 of every 100 high school students in the us (5.8%) reported current use of smokeless tobacco. health effects positions of medical organizations as of 2017, the world health organization states that "smokeless tobacco use is a significant part of the overall world tobacco problem." as of 2015, the american cancer society states that "using any kind of spit or smokeless tobacco is a major health risk. it's less lethal than smoking tobacco, but less lethal is a far cry from safe." as of 2010, the national cancer institute states that "because all tobacco products are harmful and cause cancer, the use of all of these products should be strongly discouraged. there is no safe level of tobacco use. people who use any type of tobacco product should be urged to quit". a panel of experts convened by the national institutes of health (nih) in 2006 stated that the "range of risks, including nicotine addiction, from smokeless tobacco products may vary extensively because of differing levels of nicotine, carcinogens, and other toxins in different products". according to a 2002 report by the royal college of physicians, "as a way of using nicotine, the consumption of non-combustible tobacco is of the order of 10–1,000 times less hazardous than smoking, depending on the product". as long ago as 1986, the advisory committee to the surgeon general concluded that the use of smokeless tobacco "is not a safe substitute for smoking cigarettes. it can cause cancer and a number of noncancerous oral conditions and can lead to nicotine addiction and dependence". smoking cessation quitting smokeless tobacco use is as challenging as smoking cessation. there is no scientific evidence that using smokeless tobacco can help a person quit smoking. harm reduction as of 2017, the world health organization states that "there is no evidence to recommend that any smokeless tobacco product should be used as part of a harm reduction strategy." tobacco companies that sell smokeless tobacco products promote them as harm reduction products and a less harmful substitute to cigarettes. safety smokeless tobacco products vary extensively worldwide in both form and health hazards, with some evidently toxic forms such as from south asia, and some forms with less hazards such as snus from sweden. it is correlated with a number of adverse effects such as dental disease, oral cancer, oesophagus cancer, and pancreatic cancer, cardiovascular disease, asthma, and deformities in the female reproductive system. a correlation was identified between smokeless tobacco and risk of fatal coronary artery disease and fatal stroke. use of smokeless tobacco also seems to greatly raise the risk of non-fatal ischaemic heart disease among users in asia, although not in europe. it is estimated the safety risk of smokeless tobacco is similar to that of electronic cigarettes, which has about 1% of the mortality risk of traditional cigarettes. smokeless tobacco is not a healthy alternative to cigarette smoking. there is no safe level of smokeless tobacco use. the declines in smokeless tobacco initiation among adolescents and young adults is particularly relevant to improving the health of the nation because smokeless tobacco use is often linked to subsequent cigarette initiation. smokeless tobacco users can experience these negative health consequences at any age. smokeless tobacco accounts for an abundance of deaths globally with a significant proportion of them attributed to southeast asia. youth use of tobacco in any form is unsafe. carcinogenicity graphic from the 2016 centers for disease control and prevention report entitled smokeless tobacco: health effects. all tobacco products contain toxicants, and smokeless tobacco products contain cancer-causing chemicals. the carcinogenic compounds occurring in smokeless tobacco vary widely, which rely upon the kind of product and how it was manufactured. a 2017 review found "overall, 28 carcinogens have been rigorously identified across a range of major smokeless tobacco products, primarily from 3 groups of compounds: nonvolatile, alkaloid-derived tsnas; n-nitrosoamino acids; and volatile n-nitrosamines. among these carcinogens, researchers identify tsnas as the most abundant in smokeless tobacco and the most carcinogenic." the amounts of nicotine in saliva from using smokeless tobacco could be at amounts that can cause cytotoxicity, according to in vitro studies. other chemicals found in tobacco can also cause cancer. these include: a radioactive element (polonium-210) found in tobacco fertilizer. chemicals formed when tobacco is cured with heat (polynuclear aromatic hydrocarbons—also known as polycyclic aromatic hydrocarbons). harmful metals (arsenic, beryllium, cadmium, chromium, cobalt, lead, nickel, mercury). products such as 3-(methylnitrosamino)-proprionitrile, nitrosamines, and nicotine initiate the production of reactive oxygen species in smokeless tobacco, eventually leading to fibroblast, dna, and rna damage with carcinogenic effects in the mouth of tobacco consumers. the metabolic activation of nitrosamine in tobacco by cytochrome p450 enzymes may lead to the formation of n-nitrosonornicotine, a major carcinogen, and micronuclei, which are an indicator of genotoxicity. these effects lead to further dna damage and, eventually, oral cancer. smokeless tobacco can cause white or gray patches inside the mouth (leukoplakia) that can lead to cancer. the world health organization has classified smokeless tobacco products as human carcinogenic compounds, in particular tobacco-specific nitrosamines, which account for 76 to 91% of the total n-nitroso compound (noc) burden. a 2014 review found there is "a number of ethnically linked smokeless tobacco types that contain areca nut, a group 1 carcinogen. use of areca nut-containing smokeless tobacco is known to cause oral cancer, yet despite this, prevalence is increasing in the western pacific." n-nitrosonornicotine and ketone are group 1 carcinogens to humans. these two nitrosamines found in smokeless tobacco products are the main agents for the majority of cancers in smokeless tobacco users. effects during pregnancy it is correlated with adverse reproductive effects including stillbirth, premature birth, low birth weight. using smokeless tobacco during pregnancy can increase the risk for early delivery and stillbirth. nicotine in