isoliquiritigenin isoliquiritigenin isoliquiritigenin is a phenolic chemical compound found in licorice. isoliquiritigenin names preferred iupac name 2′,4,4′-trihydroxychalcone other names 6'-deoxychalcone4,2',4'-trihydroxychalcone2',4',4-trihydroxychalcone identifiers cas number 961-29-5 y 3d model (jsmol) interactive image abbreviations iltg chebi chebi:310312 n chembl chembl129795 n chemspider 553829 n echa infocard 100.202.617 ec number 237-316-5 kegg c08650 n pubchem cid 638278 unii b9cti9gb8f y comptox dashboard (epa) dtxsid2022466 inchi inchi=1s/c15h12o4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19h/b8-3+ nkey: dxdrhhkmwqzjht-fpygclrlsa-n ninchi=1/c15h12o4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19h/b8-3+key: dxdrhhkmwqzjht-fpygclrlbb smiles c1=cc(=cc=c1c=cc(=o)c2=c(c=c(c=c2)o)o)o properties chemical formula c15h12o4 molar mass 256.257 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references metabolism the enzyme 6'-deoxychalcone synthase uses malonyl-coa, 4-coumaroyl-coa, nadph, and h+ to produce coa, isoliquiritigenin, co2, nadp+, and h2o. the enzyme isoliquiritigenin 2'-o-methyltransferase further transforms isoliquiritigenin into 2'-o-methylisoliquiritigenin. mechanism of action isoliquiritigenin has been found to be a potent (65 times higher affinity than diazepam) gaba-a benzodiapine receptor positive allosteric modulator. it can target mir-301b/lrig1 signaling pathways, resulting in the inhibition of melanoma growth in vitro.