osteonecrosis of the jaw osteonecrosis of the jaw osteonecrosis of the jaw (onj) is a severe bone disease (osteonecrosis) that affects the jaws (the maxilla and the mandible). various forms of onj have been described since 1861, and a number of causes have been suggested in the literature. osteonecrosis of the jawsother namesosteonecrosis of the mandibleosteonecrosis of the jaw of the upper left jaw in a patient diagnosed with chronic venous insufficiencyspecialtyrheumatology osteonecrosis of the jaw associated with bisphosphonate therapy, which is required by some cancer treatment regimens, has been identified and defined as a pathological entity (bisphosphonate-associated osteonecrosis of the jaw) since 2003. the possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat osteoporosis, remains uncertain. treatment options have been explored; however, severe cases of onj still require surgical removal of the affected bone. a thorough history and assessment of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered. signs and symptoms the definitive symptom of onj is the exposure of mandibular or maxillary bone through lesions in the gingiva that do not heal. pain, inflammation of the surrounding soft tissue, secondary infection or drainage may or may not be present. the development of lesions is most frequent after invasive dental procedures, such as extractions, and is also known to occur spontaneously. there may be no symptoms for weeks or months, until lesions with exposed bone appear. lesions are more common on the mandible than the maxilla. pain and neuropathy erythema and suppuration bad breath post radiation maxillary bone osteonecrosis is something that is found more in the lower jaw (mandible) rather than the maxilla (upper jaw) this is because there are many more blood vessels in the upper jaw. the symptoms of this are very similar to the symptoms of medication-related osteonecrosis of the jaw (mronj). patients are in a lot of pain, the area may swell up, bone may be seen and fractures may take place. the patients may also have a dry mouth and find it difficult to keep their mouth clean. a patient that has osteonecrosis may also be susceptible to bacterial and fungal infections. the osteoblasts, which form the bone tissue, are destroyed due to the radiation with increased activity of osteoclasts. this condition cannot be treated by antibiotics as there is no blood supply to the bone, making it difficult for the antibiotics to reach the potential infection. this condition makes eating and drinking very difficult, and surgical management removing the necrotic bone improves circulation and decreases microorganisms. causes toxic agents other factors such as toxicants can adversely impact bone cells. infections, chronic or acute, can affect blood flow by inducing platelet activation and aggregation, contributing to a localized state of excess coagulability (hypercoagulability) that may contribute to clot formation (thrombosis), a known cause of bone infarct and ischaemia. exogenous estrogens, also called hormonal disruptors, have been linked with an increased tendency to clot (thrombophilia) and impaired bone healing. heavy metals such as lead and cadmium have been implicated in osteoporosis. cadmium and lead promotes the synthesis of plasminogen activator inhibitor-1 (pai-1) which is the major inhibitor of fibrinolysis (the mechanism by which the body breaks down clots) and shown to be a cause of hypofibrinolysis. persistent blood clots can lead to congestive blood flow (hyperemia) in bone marrow, impaired blood flow and ischaemia in bone tissue resulting in lack of oxygen (hypoxia), bone cell damage and eventual cell death (apoptosis). of significance is the fact that the average concentration of cadmium in human bones in the 20th century has increased to about 10 times above the pre-industrial level. bisphosphonates main article: bisphosphonate-associated osteonecrosis of the jaw the first three reported cases of bisphosphonate-associated osteonecrosis of the jaw were spontaneously reported to the fda by an oral surgeon in 2002, with the toxicity being described as a potentially late toxicity of chemotherapy. in 2003 and 2004, three oral surgeons independently reported to the fda information on 104 cancer patients with bisphosphonate-associated osteonecrosis of the jaw seen in their referral practices in california, florida, and new york. these case series were published as peer-reviewed articles – two in the journal of oral and maxillofacial surgery and one in the journal of clinical oncology. subsequently, numerous instances of persons with this adverse drug reaction were reported to the manufacturers and to the fda. by december 2006, 3607 cases of people with this adr had been reported to the fda and 2227 cases had been reported to the manufacturer of intravenous bisphosphonates. rise in reported cases of osteonecrosis of the jaw from 1988 through 2007 the international myeloma foundation's web-based survey included 1203 respondents, 904 patients with myeloma and 299 with breast cancer and an estimate that after 36 months, osteonecrosis of the jaw had been diagnosed in 10% of 211 patients on zoledronate and 4% of 413 on pamidronate. a population based study in germany identified more than 300 cases of osteonecrosis of the jaw, 97% occurring in cancer patients (on high-dose intravenous bisphosphonates) and 3 cases in 780,000 patients with osteoporosis for an incidence of 0.00038%. time to event ranged from 23 to 39 months and 42–46 months with high dose intravenous and oral bisphosphonates. a prospective, population based study by mavrokokki et al.. estimated an incidence of osteonecrosis of the jaw of 1.15% for intravenous bisphosphonates and 0.04% for oral bisphosphonates. most cases (73%) were precipitated by dental extractions. in contrast, safety studies sponsored by the manufacturer reported bisphosphonate-associated osteonecrosis of the jaw rates that were much lower. although the majority of cases of onj have occurred in cancer patients receiving high dose intravenous bisphosphonates, almost 800 cases have been reported in oral bisphosphonate users for osteoporosis or pagets disease. in terms of severity most cases of onj in oral bisphosphonate users are stage 1–2 and tend to progress to resolution with conservative measures such as oral chlorhexidine rinses. owing to prolonged embedding of bisphosphonate drugs in the bone tissues, the risk for bronj is high even after stopping the administration of the medication for several years. this form of therapy has been shown to prevent loss of bone mineral density (bmd) as a result of a reduction in bone turnover. however, bone health entails quite a bit more than just bmd. there are many other factors to consider. in healthy bone tissue there is a homeostasis between bone resorption and ossification. diseased or damaged bone is resorbed through the osteoclasts mediated process while osteoblasts form new bone to replace it, thus maintaining healthy bone density. this process is commonly called remodelling. however, osteoporosis is essentially the result of a lack of new bone formation in combination with bone resorption in reactive hyperemia, related to various causes and contributing factors, and bisphosphonates do not address these factors at all. in 2011, a proposal incorporating both the reduced bone turnover and the infectious elements of previous theories has been put forward. it cites the impaired functionality of affected macrophages as the dominant factor in the development of onj. in a systematic review of cases of bisphosphonate-associated onj up to 2006, it was concluded that the mandible is more commonly affected than the maxilla (2:1 ratio), and 60% of cases are preceded by a dental surgical procedure. according to woo, hellstein and kalmar, oversuppression of bone turnover is probably the primary mechanism for the development of this form of onj, although there may be contributing co-morbid factors (as discussed elsewhere in this article). it is recommended that all sites of potential jaw infection should be eliminated before bisphosphonate therapy is initiated in these patients to reduce the necessity of subsequent dentoalveolar surgery. the degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alendronate (fosamax), for osteoporosis is uncertain and warrants careful monitoring. patients taking dexamethasone and other glucocorticoids are at increased risk. matrix metalloproteinase 2 may be a candidate gene for bisphosphonate-associated osteonecrosis of the jaw, since it is the only gene known to be associated with bone abnormalities and atrial fibrillation, both of which are side effects of bisphosphonates. pathophysiology histopathological alterations persons with onj may have either necrotic bone or bone marrow that has been slowly strangulated or nutrient-starved. bone with chronically poor blood flow develops either a fibrous marrow since fibres can more easily live in nutrient starved areas, a greasy, dead fatty marrow (wet rot), a very dry, sometimes leathery marrow (dry rot), or a completely hollow marrow space (osteocavitation), also typical of onj. the blood flow impairment occurs following a bone infarct, a blood clot forming inside the smaller blood vessels of cancellous bone tissue. under ischaemic conditions numerous pathological changes in the bone marrow and trabeculae of oral cancellous bone have been documented. microscopically, areas of "apparent fatty degeneration and/or necrosis, often with pooled fat from destroyed adipose cells (oil cysts) and with marrow fibrosis (reticular fatty degeneration)" are seen. these changes are present even if "most bony trabeculae appear at first glance viable, mature and otherwise normal, but closer inspection demonstrates focal loss of osteocytes and variable micro cracking (splitting along natural cleavage planes). the microscopic features are similar to those of ischaemic or aseptic osteonecrosis of long bones, corticosteroid-induced osteonecrosis, and the osteomyelitis of caisson (deep-sea diver's) disease". in the cancellous portion of femoral head it is not uncommon to find trabeculae with apparently intact osteocytes which seem to be "alive" but are no longer synthesizing collagen. this appears to be consistent with the findings in alveolar cancellous bone. osteonecrosis can affect any bone, but the hips, knees and jaws are most often involved. pain can often be severe, especially if teeth and/or a branch of the trigeminal nerve is involved, but many patients do not experience pain, at least in the earlier stages. when severe facial pain is purported to be caused by osteonecrosis, the term nico, for neuralgia-inducing cavitational osteonecrosis, is sometimes used, but this is controversial and far from completely understood. onj, even in its mild or minor forms, creates a marrow environment that is conducive to bacterial growth. since many individuals have low-grade infections of the teeth and gums, this probably is one of the major mechanisms by which the marrow blood flow problem can worsen; any local infection / inflammation will cause increased pressures and clotting in the area involved. no other bones have this mechanism as a major risk factor for osteonecrosis. a wide variety of bacteria have been cultured from onj lesions. typically, they are the same microorganisms as those found in periodontitis or devitalized teeth. however, according to special staining of biopsied tissues, bacterial elements are rarely found in large numbers. so while onj is not primarily an infection, many cases have a secondary, very low-level of bacterial infection and chronic non-suppurative osteomyelitis can be associated with onj. fungal infections in the involved bone do not seem to be a problem, but viral infections have not been studied. some viruses, such as the smallpox virus (no longer existent in the wild) can produce osteonecrosis. effects of persistent ischaemia on bone cells cortical bone is well vascularized by the surrounding soft tissues thus less susceptible to ischaemic damage. cancellous bone, with its mesh like structure and spaces filled with marrow tissue is more susceptible to damage by bone infarcts, leading to hypoxia and premature cell apoptosis. the mean life-span of osteocytes has been estimated to be 15 years in cancellous bone, and 25 years in cortical bone. while the average lifespan of human osteoclasts is about 2 to 6 weeks and the average lifespan of osteoblasts is approximately 3 months. in healthy bone these cells are constantly replaced by differentiation of bone marrow mesenchymal stem cells (msc). however, in both non-traumatic osteonecrosis and alcohol-induced osteonecrosis of the femoral head, a decrease in the differentiation ability of mesenchymal stem into bone cells has been demonstrated, and altered osteoblastic function plays a role in on of the femoral head. if these results are extrapolated to onj the altered differentiation potential of bone marrow mesenchymal stem cells (msc) combined with the altered osteoblastic activity and premature death of existing bone cells would explain the failed attempts at repair seen in ischaemic-damaged cancellous bone tissue in onj. the rapidity with