hycanthone hycanthone hycanthone is the schistosomicide approved by the fda in 1975. it is a metabolite of lucanthone. hycanthone interferes with parasite nerve function, resulting in paralysis and death. this agent also intercalates into dna and inhibits rna synthesis in vitro and shows potential antineoplastic activity. hycanthoneclinical dataatc codenoneidentifiers iupac name 1-(2-diethylaminoethylamino)-4-(hydroxymethyl)-9-thioxanthenone cas number3105-97-3 ypubchem cid3634chemspider3508 nunii2bxx5evn2akeggd00541 ychebichebi:52768 nchemblchembl22077 ncomptox dashboard (epa)dtxsid9023128 echa infocard100.019.512 chemical and physical dataformulac20h24n2o2smolar mass356.48 g·mol−13d model (jsmol)interactive image smiles ccn(cc)ccnc1=c2c(=c(c=c1)co)sc3=cc=cc=c3c2=o inchi inchi=1s/c20h24n2o2s/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23h,3-4,11-13h2,1-2h3 nkey:mfzwmtsunywvbu-uhfffaoysa-n n ny (what is this?) (verify) anti-schistosomal activity hycanthone is shown to be an effective inhibitor of acetylcholinesterase (ache) from schistosoma mansoni, but is less potential against ache from mammalian origin. this might come from differences in the configuration of active center between schistosome and mammalian ache enzymes. hycanthone is shown to intercalates into dna and inhibit rna synthesis in vitro. a growing body of evidence has shown that hycathone has an antineoplastic activity. clinical trials phase ii study of chemotherapy with hycanthone for advanced colorectal carcinoma. phase ii chemotherapy with hycanthone mesylate and flagyl for advanced malignant lymphomas (completed) physical properties physical statesolid solubilitysoluble in ethanol, methanol, dmso, and water absorption maximum233, 258, 329, 438 nm melting point173-176 °c logp3.74