keratosis punctata of the palmar creases keratosis punctata of the palmar creases keratosis punctata of the palmar creases is a common skin disorder that occurs most often in black patients, with skin lesions that are 1 to 5mm depressions filled with a comedo-like keratinous plug.: 212 keratosis punctata of the palmar creasesother nameshyperkeratosis penetrans, hyperkeratosis punctata, keratodermia punctata, keratosis punctata, keratotic pits of the palmar creases, lenticular atrophia of the palmar creases, and punctate keratosis of the palmar creasesspecialtydermatology treatment with etretinate has been described.