jnj-7777120 jnj-7777120 jnj-7777120 was a drug being developed by johnson & johnson pharmaceutical research & development which acts as a potent and selective antagonist at the histamine h4 receptor. it has anti-inflammatory effects, and has been demonstrated to be superior to traditional (h1) antihistamines in the treatment of pruritus (itching). the drug was abandoned because of its short in vivo half-life and hypoadrenocorticism toxicity in rats and dogs, that prevented advancing it into clinical studies. jnj-7777120clinical dataother names1--4-methylpiperazineidentifiers iupac name 5-chloro-2--1h-indole cas number459168-41-3 ypubchem cid4908365iuphar/bps1278chemspider4090750 nunii4h1au2v37xchemblchembl129198 ncomptox dashboard (epa)dtxsid20963461 echa infocard100.164.683 chemical and physical dataformulac14h16cln3omolar mass277.75 g·mol−13d model (jsmol)interactive image smiles c3cn(c)ccn3c(=o)c(cc1c2)c1ccc2cl inchi inchi=1s/c14h16cln3o/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16h,4-7h2,1h3 nkey:huqjrymljbbedo-uhfffaoysa-n n ny (what is this?) (verify)