emicerfont emicerfont emicerfont (gw-876,008) is a drug developed by glaxosmithkline which acts as a crf-1 antagonist. corticotropin releasing factor (crf), also known as corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress, and activates the two corticotropin-releasing hormone receptors: crf1 and crf2. this then triggers the release of corticotropin (acth), another hormone which is involved in the physiological response to stress. emicerfontclinical dataroutes ofadministrationoralatc codenoneidentifiers iupac name 1-pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one cas number786701-13-1pubchem cid11223423chemspider9398476uniioj8eg4264pkeggd09610comptox dashboard (epa)dtxsid20229231 chemical and physical dataformulac22h24n6o2molar mass404.474 g·mol−13d model (jsmol)interactive image smiles cc1=c(c=cc(=c1)oc)n2ccc3=c2n=c(c=c3n4c=cc(=n4)n5ccnc5=o)c emicerfont blocks the crf1 receptor, and so reduces acth release. it has been investigated for the treatment of irritable bowel syndrome (ibs) and alcoholism, and while it was not effective enough to be adopted for medical use in these applications, it continues to be used for research, as the role of the crh-acth system in ibs remains poorly understood.