great upheaval amongst the factions, where the lady of pain decreed that there could only be fifteen factions in sigil at one time. very little is known about this disease, but any member of the free league stood a chance of becoming infected with it simply by entering sigil. magical diseases dungeons and dragons the setting has several of varying degrees of lethality, most of them affecting one or more ability scores. the most well known are devil chills, cackle fever, filth fever, mummy rot, and slimy doom. slarecian language virus scarred lands this odd affliction can infect anyone who tries to use magic or even rudimentary means to decipher the language of the slarecian, an extinct species of evil sorcerers, if the work they are trying to decipher has this specific taint. an infected individual's language is changed to that of the slarecians (which is gibberish to most natives of scarn), meaning they can only understand or be understood by another infected victim, and all written language other than slarecian makes no sense to them. those affected do not realize what has happened to them, as what they say sounds clear to them. the disease is incredibly contagious; anyone who listens to an infected victim risks also becoming infected. ravenloft viruses ravenloft monstrous compendium appendix iii: creatures of darkness these six magical diseases were created by an evil wizard who was killed by his six sons, who each became the first carrier of one of them: combustion (the affected experiences a horrible fever and eventually bursts into flames), crystal (the victim's blood crystallizes from within), petrification (the affected gradually turns to stone) phobia (the victim becomes terrified of everything), psionic (the affected rapidly gains intelligence and psionic powers until their head explodes) and shadow (the affected eventually fades into darkness). vile diseases book of vile darkness the book mentions seventeen diseases of varying lethality caused by evil magic or exposure to focal points of incredible evil. the most notorious ones are faceless hate (causes the affected's face to vanish, and drives him to a violent, insane rage), life blindness (the victim is unable to see, hear, or otherwise perceive any other living thing, and is often driven mad from isolation and loneliness), and vile rigidity (they become stronger and tougher, but eventually, their skin hardens, until they can't move and suffocates). knahaten flu the elder scrolls the knahaten flu (also known as the knahaten plague) was one of the deadliest diseases to infect the populace of tamriel, lasting for 43 years. though exactly how the disease was introduced is unknown, it started in the swamps of black marsh. argonians, the denizens of black marsh, were immune to the disease, leading to speculation about its source, but it did not take long for it to sweep through the rest of the continent. there is no definitive death toll of the disease. however, the flu almost completely destroyed the non-argonian population of black marsh, and killed vast swathes of the population of tamriel. the exact method of transmission is unclear. early symptoms of the flu include "general malaise, loss of appetite, and fatigue," followed shortly by aching muscles, sharp pain in the shoulders, chills, and watering eyes. late-stage symptoms include wracking cough, high fever, and blood flowing out of the nose, eyes and eventually the mouth. affected individuals rarely survived longer than a few days. virally-induced toxic allergy syndrome (vitas) shadowrun caused by a highly lethal and communicable airborne virus, vitas is the disease responsible for many of the changes that led to what became the sixth world in the shadowrun universe, having killed a quarter of the world's population after its outbreak in 2011. a second strain (vitas ii) broke out in the 2020s, killing an additional 10%. symptoms begin 12 hours after infection and begin with symptoms similar to influenza before developing into severe anaphylaxis leading to death usually by the airways swelling shut. though treatable with modern drugs, at the initial outbreak of vitas over 75% of the world's population became infected before a cure was discovered. human-metahuman vampiric virus (hmhvv) shadowrun a mutagenic retrovirus that achieves its full virulence and power only in a magic-rich environment—such as post-awakening earth. the virus itself has existed throughout history and even expressed in very rare instances during the relatively magic-poor fifth world. when a metahuman's immune system fails to stave off infection, the virus begins to systematically re-shape their auras and genetic code—transforming them into forms reminiscent of the night-stalking monsters of legend. the specific form that the subject takes is dependent on their original genetic form and the strain of the virus they contract. white fever ravenloft a disease that is usually unique to the core domain of valachan. symptoms include weakness, exhaustion, chills, and loss of strength. magical remedies cannot cure it, but conventional medicine can hasten recovery. in truth, "white fever" is one of many hoaxes orchestrated by valachan's ruler, baron urik von kharkov, in order to hide his true nature from his subjects. the illness is actually caused by the vampiric feeding of the baron and his servants. blorbs mario & luigi: bowser's inside story a mysterious disease that causes toads and goombas to grow large and round rendering them mostly immobile and can make them roll uncontrollably. green poison (dollar flu) tom clancy's the division a bio-weapon created by dr gordon amherst, as a mean of controlling population. with a strain of dengue, smallpox, swineflu, h1n1, ebola, hantavirus and marburg virus. comparing to the original smallpox virus, not only does it incubate faster, it is also infectious during its incubation period. due to its rapid mutation, it is extremely difficult for antibodies and drugs to identify the virus and exterminate them as well as creating vaccine to this disease.