human alphaherpesvirus 2 human alphaherpesvirus 2 human alphaherpesvirus 2 (hhv-2) is a species of virus in the genus simplexvirus, subfamily alphaherpesvirinae, family herpesviridae, and order herpesvirales. human alphaherpesvirus 2 transmission electron micrograph of herpes simplex virus virus classification (unranked): virus realm: duplodnaviria kingdom: heunggongvirae phylum: peploviricota class: herviviricetes order: herpesvirales family: herpesviridae genus: simplexvirus species: human alphaherpesvirus 2 synonyms herpes simplex virus evolution human alphaherpesvirus 2 can be divided into two clades: one is globally distributed and the other is mostly limited to sub saharan africa. pathology