armodafinil armodafinil armodafinil (trade name nuvigil) is the enantiopure compound of the eugeroic modafinil (provigil). it consists of only the (r)-(−)-enantiomer of the racemic modafinil. armodafinil is produced by the pharmaceutical company cephalon inc. and was approved by the u.s. food and drug administration (fda) in june 2007. in 2016, the fda granted mylan rights for the first generic version of cephalon's nuvigil to be marketed in the u.s. armodafinilclinical datatrade namesnuvigil, othersahfs/drugs.commonographmedlineplusa602016pregnancycategory c dependenceliabilitylowroutes ofadministrationoral (tablets)atc coden06ba13 (who) legal statuslegal status au: s4 (prescription only) us: schedule iv pharmacokinetic datametabolismliver, including cyp3a4 and other pathwayselimination half-life12–15 hoursexcretionurine (as metabolites)identifiers iupac name (–)-2-acetamide cas number112111-43-0 npubchem cid9690109chemspider7962943 yuniiv63xwa605ikeggd03215 ychebichebi:77590 nchemblchembl1201192 ncomptox dashboard (epa)dtxsid90920667 echa infocard100.207.833 chemical and physical dataformulac15h15no2smolar mass273.35 g·mol−13d model (jsmol)interactive image smiles c1=cc=c(c=c1)c(c2=cc=cc=c2)(=o)cc(=o)n inchi inchi=1s/c15h15no2s/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15h,11h2,(h2,16,17)/t19-/m1/s1 ykey:yfghcgitmmyxaq-ljqanchmsa-n y ny (what is this?) (verify) because armodafinil has a longer half-life than modafinil does, it may be more effective at improving wakefulness in patients with excessive daytime sleepiness. medical uses armodafinil is currently fda-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. it is commonly used off-label to treat attention deficit hyperactivity disorder, chronic fatigue syndrome, and major depressive disorder, and has been repurposed as an adjunctive treatment for bipolar disorder. it has been shown to improve vigilance in air traffic controllers, however in the united states, sleep prevention medications such as provigil (modafinil) and nuvigil (armodafinil) are not approved by the faa for civilian controllers or pilots. bipolar disorder armodafinil, along with racemic modafinil, has been repurposed as an adjunctive treatment for acute depression in people with bipolar disorder. meta-analytic evidence showed that add-on modafinil and armodafinil were more effective than placebo on response to treatment, clinical remission, and reduction in depressive symptoms, with only minor side effects, but the effect sizes are small and the quality of evidence has to be considered low, limiting the clinical relevance of current evidence. however current dosage for bipolar disorder is 150 mg od. also, paradoxical tiredness and sleeping is observed in some cases. schizophrenia