phenomorphan phenomorphan phenomorphan is an opioid analgesic. it is not currently used in medicine, but has similar side-effects to other opiates, which include itching, nausea and respiratory depression. phenomorphanclinical dataother names(-)-3-hydroxy- n- (2-phenylethyl) morphinanatc codenonelegal statuslegal status au: s9 (prohibited substance) ca: schedule i de: anlage i (authorized scientific use only) uk: class a us: schedule i identifiers iupac name 17-(2-phenylethyl)morphinan-3-ol cas number468-07-5 ypubchem cid5362458chemspider16735962 yunii26hxe4b73pcomptox dashboard (epa)dtxsid70878657 echa infocard100.006.732 chemical and physical dataformulac24h29nomolar mass347.502 g·mol−13d model (jsmol)interactive image smiles oc3ccc4c1n(cc2(cccc12)c4c3)ccc5ccccc5 inchi inchi=1s/c24h29no/c26-20-10-9-19-16-23-21-8-4-5-12-24(21,22(19)17-20)13-15-25(23)14-11-18-6-2-1-3-7-18/h1-3,6-7,9-10,17,21,23,26h,4-5,8,11-16h2/t21-,23+,24+/m0/s1 ykey:cfbqywxpzvqqtn-qptuxgolsa-n y (verify) phenomorphan is a highly potent drug due to the n-phenethyl group, which boosts affinity to the μ-opioid receptor, and so phenomorphan is around 10x more potent than levorphanol, which is itself 6-8x the potency of morphine. other analogues where the n-(2-phenylethyl) group has been replaced by other aromatic rings are even more potent, with the n-(2-(2-furyl)ethyl) and the n-(2-(2-thienyl)ethyl) analogues being 60x and 45x stronger than levorphanol, respectively.