am-411 am-411 am-411 (part of the am cannabinoid series) is an analgesic drug that is a cannabinoid agonist. it is a derivative of δ8-thc substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk. am-411identifiers iupac name (6ar,10ar)-3-(1-adamantyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzochromen-1-ol cas number212835-02-4 ypubchem cid9799945chemspider7975710 yunii2k9ws7sur3chemblchembl434351 ychemical and physical dataformulac26h34o2molar mass378.556 g·mol−13d model (jsmol)interactive image smiles c5c6cc4cc5(cc(c6)c4)c(cc1o3)cc(o)c1c2cc(c)=ccc2c3(c)c inchi inchi=1s/c26h34o2/c1-15-4-5-21-20(6-15)24-22(27)10-19(11-23(24)28-25(21,2)3)26-12-16-7-17(13-26)9-18(8-16)14-26/h4,10-11,16-18,20-21,27h,5-9,12-14h2,1-3h3/t16?,17?,18?,20-,21-,26?/m1/s1 ykey:rpbmpwgkzflmfn-okfsjjlxsa-n y (verify) am-411 is a potent and fairly selective cb1 full agonist with a ki of 6.80 nm, but is still also a moderately potent cb2 agonist with a ki of 52.0 nm. it produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis.