pf-04745637 pf-04745637 pf-04745637 is a drug which acts as a potent and selective antagonist for the trpa1 receptor, with an ic50 of 17nm, vs ~3μm at the related trpv1 and trpm channels. it has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis. pf-04745637identifiers iupac name 1-(4-chlorophenyl)-n--3-phenylpropyl]cyclopentane-1-carboxamide cas number1917294-46-2pubchem cid121304827chemblchembl4208555chemical and physical dataformulac27h32clf3n2o2molar mass509.01 g·mol−13d model (jsmol)interactive image smiles c1ccc(c1)(c2=cc=c(c=c2)cl)c(=o)nc(cc3=cc=cc=c3)n4ccc(cc4)(c(f)(f)f)o inchi inchi=1s/c27h32clf3n2o2/c28-22-10-8-21(9-11-22)25(12-4-5-13-25)24(34)32-19-23(18-20-6-2-1-3-7-20)33-16-14-26(35,15-17-33)27(29,30)31/h1-3,6-11,23,35h,4-5,12-19h2,(h,32,34)/t23-/m1/s1key:paebejvpsadomc-hszrjfapsa-n