dimestrol dimestrol dimestrol (brand names depot-cyren, depot-oestromon), also known as dianisylhexene, 4,4'-dimethoxy-α,α'-diethylstilbene, diethylstilbestrol dimethyl ether, and dimethoxydiethylstilbestrol, is a synthetic nonsteroidal estrogen of the stilbestrol group which is related to diethylstilbestrol. it has been used clinically as a hormonal therapy in cases of delayed female puberty, hypogonadism, menopausal, and postmenopausal symptoms. it is known to induce the development of female secondary sexual characteristics in the case of female delayed puberty or hypogonadism. the drug has also been used as a growth promoter in livestock. not to be confused with dimethylstilbestrol. dimestrolclinical datatrade namesdepot-ostromon; depot-oestromon; depot-cyren; synthilaother namesdianisylhexene; 4,4'-dimethoxy-α,α'-diethylstilbene; diethylstilbestrol dimethyl ether; dimethoxydiethylstilbestrol; (e)-4,4'-(1,2-diethylethylene)dianisoledrug classnonsteroidal estrogen; estrogen etheridentifiers iupac name 1-methoxy-4-benzene cas number130-79-0pubchem cid3032539chemspider2297488unii6h0ma01ftskeggc14391chemblchembl113650comptox dashboard (epa)dtxsid4022494 echa infocard100.004.542 chemical and physical dataformulac20h24o2molar mass296.410 g·mol−13d model (jsmol)interactive image smiles ccc(=c(cc)c1=cc=c(c=c1)oc)c2=cc=c(c=c2)oc inchi inchi=1s/c20h24o2/c1-5-19(15-7-11-17(21-3)12-8-15)20(6-2)16-9-13-18(22-4)14-10-16/h7-14h,5-6h2,1-4h3/b20-19+key:vqoaqmikpyncmv-fmqucbeesa-n des is a known endocrine disrupting chemical. molecularly, it is known to increase the risk of aneuploidy via interference with microtubule assembly. prior to the 1950s, des was widely prescribed to pregnant women to prevent miscarriage and preterm labor. a study released in the 1950s found that women who were exposed to des were at increased risk for cervical and vaginal clear cell adenocarcinoma. shortly after this finding, the fda discouraged the prescription of des to pregnant women. children were also affected by the maternal use of des during their gestation. study findings showed that daughters were more likely to develop fertility complications such as premature delivery, neonatal death, miscarriage, ectopic pregnancy, stillbirth, infertility, and preeclampsia. des exposed sons may also experience genital abnormalities but no conclusive increased risk of infertility. in the case of suspected or known exposure to des before, women are encouraged to receive pelvic examinations, pap tests, biopsies, and breast examinations. men should receive routine examinations from their physician in the case of suspected or potential exposure. the medication has a long duration of action of 6 weeks given by intramuscular injection. parenteral potencies and durations of nonsteroidal estrogens estrogenformmajor brand name(s)epd (14 days)duration diethylstilbestrol (des)oil solutionmetestrol20 mg1 mg ≈ 2–3 days; 3 mg ≈ 3 days diethylstilbestrol dipropionateoil solutioncyren b12.5–15 mg2.5 mg ≈ 5 days aqueous suspension ?5 mg ? mg = 21–28 days dimestrol (des dimethyl ether)oil solutiondepot-cyren, depot-oestromon, retalon retard20–40 mg ? fosfestrol (des diphosphate)aaqueous solutionhonvan ?<1 day dienestrol diacetateaqueous suspensionfarmacyrol-kristallsuspension50 mg ? hexestrol dipropionateoil solutionhormoestrol, retalon oleosum25 mg ? hexestrol diphosphateaaqueous solutioncytostesin, pharmestrin, retalon aquosum ?very short note: all by intramuscular injection unless otherwise noted. footnotes: a = by intravenous injection. sources: see template.