tolazoline tolazoline tolazoline is a non-selective competitive α-adrenergic receptor antagonist. it is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). it has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-ht2a agonist drugs such as 25i-nbome, dob and bromodragonfly (prolonged severe vasoconstriction can lead to gangrene if untreated). tolazolineclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationivatc codec04ab02 (who) m02ax02 (who) qv03ab94 (who)identifiers iupac name 2-benzyl-4,5-dihydro-1h-imidazole cas number59-98-3 ypubchem cid5504iuphar/bps7310drugbankdb00797 ychemspider5303 yuniichh9h12aq3keggd08614 ychebichebi:28502 ychemblchembl770 ycomptox dashboard (epa)dtxsid3023683 echa infocard100.000.408 chemical and physical dataformulac10h12n2molar mass160.220 g·mol−13d model (jsmol)interactive image smiles n\1=c(\ncc/1)cc2ccccc2 inchi inchi=1s/c10h12n2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5h,6-8h2,(h,11,12) ykey:jivzkjjqozqxqb-uhfffaoysa-n y (verify) for other uses, see adrenergics. it is however most commonly used in veterinary medicine, to reverse xylazine-induced sedation.