primary cutaneous follicle center lymphoma primary cutaneous follicle center lymphoma primary cutaneous follicle center lymphoma is a type of lymphoma. it was recognized as a distinct disease entity in the 2008 who classification.: 218 pcfcl had been previously conceived as a variant of follicular lymphoma (fl).: 218 primary cutaneous follicle center lymphomaother namespcfclspecialtyhematology/oncology cause unlike fl, pcfcl is not typically associated with t(14;18) translocation: 218 although presence of that translocation does not exclude pcfcl.: 314 it is usually not associated with overexpressed bcl-2.: 218 pcfcl represents about 55% to 60% of primary cutaneous b-cell lymphomas (pcbcl);: 373 primary cutaneous marginal zone lymphoma and diffuse large b-cell cell lymphoma, leg type are the other primary cutaneous b-cell lymphomas.: 373 the cause of pcfcl is unknown.: 312 treatment surgical removal and/or radiotherapy is given for localized disease.: 314 radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions.: 314 for the less common situation of more extensive disease (still confined to skin), rituximab without chemotherapy is used.: 314 intralesional interferon alpha (ifn-α) and intralesional rituximab have been used.: 314 approximately one-third of pcfcl relapse, usually in the skin; treatment is similar to initial management and overall survival remains excellent. prognosis spread from the skin is unusual, and the prognosis is excellent: 218 with a 5-year survival of over 97%.: 314 the international extranodal lymphoma study group identified elevated ldh, more than two skin lesions, and nodular lesions as three prognostic factors, that are used to assess a cutaneous lymphoma international prognostic index (clipi), which is prognostic of disease-free status.