ro4491533 ro4491533 ro-4491533 is a drug developed by hoffmann-la roche which acts as a potent and selective negative allosteric modulator for group ii of the metabotropic glutamate receptors (mglur2/3), being equipotent at mglur2 and mglur3 but without activity at other mglur subtypes. in animal studies, ro-4491533 produced antidepressant effects and reversed the effects of the mglur2/3 agonist ly-379,268 with similar efficacy but slightly lower potency than the mglur2/3 antagonist ly-341,495. a number of related compounds are known, with similar effects in vitro and a fairly well characterized structure-activity relationship. ro4491533clinical dataatc codenonelegal statuslegal status in general: non-regulated identifiers iupac name 4--7-methyl-8-trifluoromethyl-1,3-dihydrobenzodiazepin-2-one cas number579482-31-8 ypubchem cid11158623iuphar/bps6226chemspider9333726uniihf59bt62ugchemical and physical dataformulac24h20f3n3omolar mass423.439 g·mol−13d model (jsmol)interactive image smiles n3c(c)cc(cc3c)-c(ccc4)cc4c(=nc1cc2c)cc(=o)nc1cc2c(f)(f)f inchi inchi=1s/c24h20f3n3o/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11h,12h2,1-3h3,(h,30,31)key:lytvxcqqtlueqr-uhfffaoysa-n