proadifen proadifen proadifen (skf-525a) is a non-selective inhibitor of cytochrome p450 enzymes, preventing some types of drug metabolism. it is also an inhibitor of neuronal nitric oxide synthase (nos), cyp-dependent (cytochrome p450-dependent) arachidonate metabolism, transmembrane calcium influx, and platelet thromboxane synthesis. further documented effects include the blockade of atp-sensitive inward rectifier potassium channel 8 (kir6.1), and stimulation of endothelial cell prostacyclin production. proadifen names preferred iupac name 2-(diethylamino)ethyl 2,2-diphenylpentanoate other names skf 525-a identifiers cas number 302-33-0 3d model (jsmol) interactive image chembl chembl282567 chemspider 4741 pubchem cid 4910 unii a510ca4cbt y comptox dashboard (epa) dtxsid2048452 inchi inchi=1s/c23h31no2/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3/h7-16h,4-6,17-19h2,1-3h3 smiles o=c(occn(cc)cc)c(c1ccccc1)(c2ccccc2)ccc properties chemical formula c23h31no2 molar mass 353.506 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references proadifen exerts apoptotic/anti-proliferate (tumour suppressing) effects in certain forms of cancer (ht-29 colon adenocarcinoma), believed to be caused by mediation of glycogen synthase kinase 3 β (gsk-3β). in the same study administration of proadifen was demonstrated to produce time- and dose-dependent phosphatidylserine externalization, caspase-3 activation and parp cleavage. intense upregulation of nag-1 and atf3 and downregulation of mcl-1 and egr-1 were also observed. proadifen has been demonstrated to normally inhibit the nicotinic acetylcholine receptor (nachr) and muscarinic acetylcholine receptor (machr) in rats.