peripheral mononeuropathy peripheral mononeuropathy peripheral mononeuropathy is a nerve related disease where a single nerve, that is used to transport messages from the brain to the peripheral body, is diseased or damaged. peripheral neuropathy is a general term that indicates any disorder of the peripheral nervous system. the name of the disorder itself can be broken down in order to understand this better; peripheral: in regard to peripheral neuropathy, refers to outside of the brain and spinal cord; neuro: means nerve related; -pathy; means disease. peripheral mononeuropathy is a disorder that links to peripheral neuropathy, as it only effects a single peripheral nerve rather than several damaged or diseased nerves throughout the body. healthy peripheral nerves are able to “carry messages from the brain and spinal cord to muscles, organs, and other body tissues”.