sappinia amoebic encephalitis sappinia amoebic encephalitis sappinia amoebic encephalitis (sae) is the name for amoebic encephalitis caused by species of sappinia. sappinia amoebic encephalitisspecialtyinfectious disease the causative organism was originally identified as sappinia diploidea, but is now considered to be sappinia pedata. it has been treated with azithromycin, pentamidine, itraconazole, and flucytosine.