renal cell carcinoma with t(6;11) translocation renal cell carcinoma with t(6;11) translocation renal cell carcinoma with t(6;11) translocation or tfeb-amplified renal cell carcinomas is rare subtype of renal cell carcinoma. the t(6;11)(p21;q12) translocation fuses the alpha (malat1) gene with the tfeb transcription factor gene, resulting in upregulated expression of tfeb which leads to expression of melanocytic markers. renal cell carcinoma with t(6;11) translocationspecialtyoncology/nephrology