apolipoprotein a-ii apolipoprotein a-ii apolipoprotein a-ii is a protein that in humans is encoded by the apoa2 gene. apoa2available structurespdbortholog search: pdbe rcsb list of pdb id codes1l6l, 2ou1identifiersaliasesapoa2, apo-aii, apoa-ii, apoaii, apolipoprotein a2external idsmgi: 88050 homologene: 1242 genecards: apoa2 gene location (human)chr.chromosome 1 (human)band1q23.3start161,222,292 bpend161,223,631 bpgene location (mouse)chr.chromosome 1 (mouse)band1 h3|1 79.22 cmstart171,052,623 bpend171,053,948 bprna expression patternbgeehumanmouse (ortholog)top expressed inright lobe of livermonocytebone marrow cellsleft uterine tubebloodright coronary arteryright uterine tuberight lungbody of pancreasoocytetop expressed inleft lobe of liveryolk sacabdominal wallproximal tubulesexually immature organismplacentastomachatrioventricular valvesupraoptic nucleusduodenummore reference expression databiogpsmore reference expression datagene ontologymolecular function lipase inhibitor activity protein homodimerization activity phosphatidylcholine binding lipid transporter activity apolipoprotein receptor binding high-density lipoprotein particle receptor binding cholesterol binding protein binding protein heterodimerization activity phosphatidylcholine-sterol o-acyltransferase activator activity phospholipid binding cholesterol transfer activity lipid binding high-density lipoprotein particle binding heat shock protein binding signaling receptor binding cellular component cytosol blood microparticle endoplasmic reticulum lumen chylomicron very-low-density lipoprotein particle spherical high-density lipoprotein particle extracellular region early endosome high-density lipoprotein particle extracellular exosome extracellular space biological process negative regulation of cholesterol import negative regulation of very-low-density lipoprotein particle remodeling diacylglycerol catabolic process lipid transport regulation of protein stability positive regulation of cholesterol esterification phospholipid efflux cholesterol transport positive regulation of lipid catabolic process response to glucocorticoid negative regulation of cytokine production involved in immune response response to glucose high-density lipoprotein particle assembly retinoid metabolic process response to estrogen high-density lipoprotein particle remodeling negative regulation of lipase activity regulation of intestinal cholesterol absorption low-density lipoprotein particle remodeling acute inflammatory response animal organ regeneration phospholipid catabolic process peptidyl-methionine modification cholesterol efflux negative regulation of cholesterol transport cholesterol homeostasis phosphatidylcholine biosynthetic process negative regulation of cholesterol transporter activity viral process negative regulation of lipid catabolic process triglyceride-rich lipoprotein particle remodeling triglyceride metabolic process reverse cholesterol transport high-density lipoprotein particle clearance positive regulation of catalytic activity cholesterol metabolic process regulation of lipid metabolic process chylomicron remodeling chylomicron assembly lipoprotein metabolic process post-translational protein modification transport positive regulation of phagocytosis protein stabilization sources:amigo / quickgoorthologsspecieshumanmouseentrez33611807ensemblensg00000158874ensmusg00000005681uniprotp02652p09813refseq (mrna)nm_001643nm_013474nm_001305549nm_001305550nm_001305585refseq (protein)np_001634np_001292478np_001292479np_001292514np_038502location (ucsc)chr 1: 161.22 – 161.22 mbchr 1: 171.05 – 171.05 mbpubmed searchwikidataview/edit humanview/edit mouse apoa-iistructures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactionsidentifierssymbolapoa-iipfampf04711interproipr006801scop21l6k / scope / supfamavailable protein structures:pfam structures / ecod pdbrcsb pdb; pdbe; pdbjpdbsumstructure summary function apoa2 encodes apolipoprotein a-ii (apoa-ii), which is the second most abundant protein of the high density lipoprotein particles. the protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein d. defects in this gene may result in apolipoprotein a-ii deficiency or hypercholesterolemia. interactions apoa-ii has been shown to interact with phospholipid transfer protein. interactive pathway map click on genes, proteins and metabolites below to link to respective articles. [[file: |alt=statin pathway edit]] statin pathway edit the interactive pathway map can be edited at wikipathways: "statin_pathway_wp430".