hemoglobin subunit zeta hemoglobin subunit zeta hemoglobin subunit zeta is a protein that in humans is encoded by the hbz gene. hbzavailable structurespdbortholog search: pdbe rcsb list of pdb id codes1jeb, 3w4uidentifiersaliaseshbz, hbz-t1, hbz1, hemoglobin subunit zeta, hbazexternal idsomim: 142310 mgi: 96019 homologene: 110705 genecards: hbz gene location (human)chr.chromosome 16 (human)band16p13.3start142,728 bpend154,503 bpgene location (mouse)chr.chromosome 11 (mouse)band11 a4|11 18.86 cmstart32,226,400 bpend32,228,116 bprna expression patternbgeehumanmouse (ortholog)top expressed inbloodganglionic eminencebone marrowsubcutaneous adipose tissueamygdalaplacentamonocytenucleus accumbenshippocampus properdorsolateral prefrontal cortextop expressed inyolk sacabdominal wallmaxillary prominenceinternal carotid arteryexternal carotid arteryhandsomiteendocardial cushionmedial ganglionic eminenceatriummore reference expression databiogpsmore reference expression datagene ontologymolecular function iron ion binding oxygen binding protein binding heme binding metal ion binding oxygen carrier activity peroxidase activity haptoglobin binding organic acid binding cellular component hemoglobin complex extracellular exosome haptoglobin-hemoglobin complex biological process oxygen transport negative regulation of transcription by rna polymerase ii erythrocyte maturation transport hydrogen peroxide catabolic process protein heterooligomerization cellular oxidant detoxification sources:amigo / quickgoorthologsspecieshumanmouseentrez305015126ensemblensg00000130656ensmusg00000055609uniprotp02008p06467refseq (mrna)nm_005332nm_010405refseq (protein)np_005323np_034535location (ucsc)chr 16: 0.14 – 0.15 mbchr 11: 32.23 – 32.23 mbpubmed searchwikidataview/edit humanview/edit mouse zeta-globin is an alpha-like hemoglobin. the zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. the zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. the order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.