open lung ventilation open lung ventilation within the medical field of respiratory therapy, open lung ventilation is a strategy that is utilized by several modes of mechanical ventilation to combine low tidal volume and applied peep to maximize recruitment of alveoli. the low tidal volume aims to minimize alveolar overdistention and the peep minimizes cyclic atelectasis. working in tandem the effects from both decrease the risk of ventilator-associated lung injury. open lung ventilationspecialtypulmonology benefit some clinical trials indicate that open lung ventilation may improve mortality, other clinically important outcomes, and oxygenation. dangers open lung ventilation is generally well tolerated. application a universally accepted protocol for open lung ventilation has not been established.