pipapillomavirus pipapillomavirus pipapillomavirus is a genus of viruses, in the family papillomaviridae. hamsters serve as natural hosts. there are two species in this genus. diseases associated with this genus include: cutaneous lesions. pipapillomavirus virus classification (unranked): virus realm: monodnaviria kingdom: shotokuvirae phylum: cossaviricota class: papovaviricetes order: zurhausenvirales family: papillomaviridae genus: pipapillomavirus taxonomy the following two species are assigned to the genus: pipapillomavirus 1 pipapillomavirus 2 structure viruses in pipapillomavirus are non-enveloped, with icosahedral geometries, and t=7 symmetry. the diameter is around 52-55 nm. genomes are circular. the genome has 22 open reading frames. genusstructuresymmetrycapsidgenomic arrangementgenomic segmentation pipapillomavirusicosahedralt=7non-envelopedcircularmonopartite life cycle viral replication is nuclear. entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. replication follows the dsdna bidirectional replication model. dna-templated transcription, with some alternative splicing mechanism is the method of transcription. the virus exits the host cell by nuclear envelope breakdown. hamsters serve as the natural host. transmission routes are contact. genushost detailstissue tropismentry detailsrelease detailsreplication siteassembly sitetransmission pipapillomavirushamstersepithelial: mucous; epithelial: skincell receptor endocytosislysisnucleusnucleuscontact