dihydrostreptomycin dihydrostreptomycin dihydrostreptomycin is a derivative of streptomycin that has a bactericidal properties. it is a semisynthetic aminoglycoside antibiotic used in the treatment of tuberculosis. dihydrostreptomycinclinical dataahfs/drugs.cominternational drug namesatc codes01aa15 (who) qa07aa90 (who) qj01ga90 (who) qj51ga90 (who)identifiers iupac name 2-oxy-4-hydroxy-4-(hydroxymethyl)- 5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine cas number128-46-1pubchem cid439369chemspider388489uniip2i6r8w6uachemblchembl1950576comptox dashboard (epa)dtxsid0022937 echa infocard100.004.445 chemical and physical dataformulac21h41n7o12molar mass583.596 g·mol−13d model (jsmol)interactive image smiles c1(((o1)o2((((2o)o)nc(=n)n)o)nc(=n)n)o3((((o3)co)o)o)nc)(co)o inchi inchi=1s/c21h41n7o12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h5-18,26,29-36h,3-4h2,1-2h3,(h4,22,23,27)(h4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1key:asxbyywolisclq-hzyvhmacsa-n (verify) it acts by irreversibly binding the s12 protein in the bacterial 30s ribosomal subunit, after being actively transported across the cell membrane, which interferes with the initiation complex between the mrna and the bacterial ribosome. this leads to the synthesis of defective, nonfunctional proteins, which results in the bacterial cell's death. it causes ototoxicity, which is why it is no longer used in humans.