mechanisms. medically speaking, phospholipids can often be recruited in autoimmune responses, most commonly observed in cases of fetal loss during pregnancy. in such cases, antibodies against annexin a-v destroy its 2-dimensional crystal structure and uncover the phospholipids in the membrane, making them available for contribution to various coagulation mechanisms. fibrinolysis while several annexins may be involved in mechanisms of fibrinolysis, annexin a-ii is the most prominent in mediating these responses. the expression of annexin a-ii on the cell surface is believed to serve as a receptor for plasminogen, which functions to produce plasmin. plasmin initiates fibrinolysis by degrading fibrin. the destruction of fibrin is a natural preventative measure because it prevents the formation of blood clots by fibrin networks. annexin a-ii has medical implications because it can be utilized in treatments for various cardiovascular diseases that thrive on blood clotting through fibrin networks. types/subfamilies annexin, type i interpro: ipr002388 annexin, type ii interpro: ipr002389 annexin, type iii interpro: ipr002390 annexin, type iv interpro: ipr002391 annexin, type v interpro: ipr002392 annexin, type vi interpro: ipr002393 alpha giardin interpro: ipr008088 annexin, type x interpro: ipr008156 annexin, type viii interpro: ipr009115 annexin, type xxxi interpro: ipr009116 annexin, type fungal xiv interpro: ipr009117 annexin, type plant interpro: ipr009118 annexin, type xiii interpro: ipr009166 annexin, type vii interpro: ipr013286 annexin like protein interpro: ipr015472 annexin xi interpro: ipr015475 human proteins containing this domain anxa1; anxa10; anxa11; anxa13; anxa2; anxa3; anxa4; anxa5; anxa6; anxa7; anxa8; anxa8l1; anxa8l2; anxa9;