ly-341495 ly-341495 ly-341495 is a research drug developed by the pharmaceutical company eli lilly, which acts as a potent and selective orthosteric antagonist for the group ii metabotropic glutamate receptors (mglur2/3). ly-341495clinical dataother names(2s)-2-amino-2--3-(xanth-9-yl)propanoic acididentifiers iupac name 2--3-(9h-xanthen-9-yl)-d-alanine cas number201943-63-7 ychemspider7995676 nuniiaq73sp6qsfcomptox dashboard (epa)dtxsid50942264 chemical and physical dataformulac20h19no5molar mass353.374 g·mol−13d model (jsmol)interactive image smiles c1(1(cc2c3=cc=cc=c3oc4=cc=cc=c24)(c(=o)o)n)c(=o)o inchi inchi=1s/c20h19no5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15h,9-10,21h2,(h,22,23)(h,24,25)/t13-,15-,20-/m0/s1 nkey:vlzbrvjvccnprj-kphuokfysa-n n ny (what is this?) (verify) it is used in scientific research in several different areas, showing antidepressant effects in animal models, increasing the behavioural effects of hallucinogenic drugs in animal tests, and increasing the analgesic effects of μ-opioid agonists, as well as modulating dopamine receptor function. the 1-fluorocyclopropane analog has a superior pharmacokinetic profile and similar mglur2/3 affinity, and making a prodrug from this with the heptyl ester increases bioavailability still further. 1-fluoro-ly-341,495 heptyl ester