laudexium metilsulfate laudexium metilsulfate laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. laudexium metilsulfateclinical dataother nameslaudolissinroutes ofadministrationivlegal statuslegal status discontinued from clinical use pharmacokinetic databioavailability100% (iv)identifiers iupac name 1--2--6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-2-ium methyl sulfate cas number3253-60-9 ypubchem cid18618chemspider17584 nuniid067kdg4nuchemical and physical dataformulac54h80n2o16s2molar mass1077.35 g·mol−13d model (jsmol)interactive image smiles c1(ccc2=cc(=c(c=c2c1cc3=cc(=c(c=c3)oc)oc)oc)oc)cccccccccc4(ccc5=cc(=c(c=c5c4cc6=cc(=c(c=c6)oc)oc)oc)oc)c.cos(=o)(=o).cos(=o)(=o) inchi inchi=1s/c52h74n2o8.2ch4o4s/c1-53(27-23-39-33-49(59-7)51(61-9)35-41(39)43(53)29-37-19-21-45(55-3)47(31-37)57-5)25-17-15-13-11-12-14-16-18-26-54(2)28-24-40-34-50(60-8)52(62-10)36-42(40)44(54)30-38-20-22-46(56-4)48(32-38)58-6;2*1-5-6(2,3)4/h19-22,31-36,43-44h,11-18,23-30h2,1-10h3;2*1h3,(h,2,3,4)/q+2;;/p-2 nkey:ladqayslflckod-uhfffaoysa-l n ny (what is this?) (verify) laudexium is no longer used in clinical practice, though it was introduced clinically in the early 1950s. it has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine. as with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its pharmacological action can be antagonized by anticholinesterases. the displacement of laudexium from clinical use was assured owing to recurrent reports of significant post-operative re-curarization.