aceperone aceperone aceperone is a neuroleptic drug of the butyrophenone class. it is an α-noradrenergic blocking drug developed by janssen pharmaceutica in the 1960s. aceperoneclinical dataother namesacetabuton; r 3248atc codenoneidentifiers iupac name n-(methyl)acetamide cas number807-31-8pubchem cid13122chemspider12570uniis69kxz59abchemblchembl136298comptox dashboard (epa)dtxsid30230510 chemical and physical dataformulac24h29fn2o2molar mass396.506 g·mol−13d model (jsmol)interactive imagemelting point97 to 100 °c (207 to 212 °f) smiles fc1ccc(cc1)c(=o)cccn3ccc(c2ccccc2)(cc3)cnc(=o)c inchi inchi=1s/c24h29fn2o2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12h,5,8,13-18h2,1h3,(h,26,28)key:vdgzermdpaazej-uhfffaoysa-n aceperone has been used as a tool in the study of the biochemical basis of learning. although aceperone does not block learning per se, it blocks access to an attentional mechanism by which animals ‘tune in’ to the relevant visual dimension when learning a visual discrimination task at doses below those that affect general behaviour. synthesis patent: the reduction of 1-benzyl-4-cyano-4-phenylpiperidine (1) with lithium aluminium hydride gives 1-benzyl-4-phenylpiperidine-4-methylamine (2). acetylation of this primary amine would yield (3). the removal of the benzyl protecting group by catalytic hydrogenation gives n-acetamide (4). alkylation with 4-chloro-4'-fluorobutyrophenone (5) affords aceperone (6).