weber–christian disease weber–christian disease weber–christian disease, is a cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin. weber–christian diseaseother namesrelapsing febrile nodular nonsuppurative panniculitisspecialtyrheumatology it is a type of panniculitis. it is a rare disease seen in females 30–60 years of age. it is a recurring inflammation of fatty layers of tissue present beneath the skin. clinical course is characterised by exacerbations and remissions. lesions are bilaterally symmetrical and are usually seen in the lower legs. eponym it is named after frederick parkes weber and henry asbury christian.