ionis-gccrrx ionis-gccrrx ionis-gccrrx, also known as isis-426115, is an antiglucocorticoid which is under development by ionis pharmaceuticals (formerly isis pharmaceuticals) for the treatment of diabetes mellitus type 2. it has also been under investigation for the treatment of cushing's syndrome, but no development has been reported. the drug is an antisense oligonucleotide against the glucocorticoid receptor. as of december 2017, it is in phase ii clinical trials for diabetes mellitus type 2. ionis-gccrrxclinical dataother namesisis-426115; isis-gccrrxdrug classantiglucocorticoididentifiersunii6c4tx6t1co