6'-guanidinonaltrindole 6'-guanidinonaltrindole 6′-guanidinonaltrindole (6′-gnti) is a κ–δ-opioid receptor selective ligand used in scientific research. 6′-guanidinonaltrindole names iupac name n-morphinan-6′-yl]guanidine systematic iupac name n-benzofuropyridocarbazol-12-yl]guanidine identifiers cas number 350693-06-0 3d model (jsmol) interactive image chembl chembl610279 chemspider 24674392 pubchem cid 9912633 inchi inchi=1s/c27h29n5o3/c28-25(29)30-15-4-5-16-17-11-27(34)20-9-14-3-6-19(33)23-21(14)26(27,7-8-32(20)12-13-1-2-13)24(35-23)22(17)31-18(16)10-15/h3-6,10,13,20,24,31,33-34h,1-2,7-9,11-12h2,(h4,28,29,30)/t20-,24+,26+,27-/m1/s1key: xdkogaafsbglbo-gyhunedqsa-n smiles c1cc2c(cc1nc(=n)n)c3c2cc4(c5cc6ccc(c7c6c4(c3o7)ccn5cc8cc8)o)o properties chemical formula c27h29n5o3 molar mass 471.561 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references with 6′-gnti, evidence was provided for the first time that receptor oligomerization plays functional role in living organisms. 6′-gnti is an extremely biased agonist of the κ-opioid receptor. it is a potent partial agonist of the g protein pathway but does not recruit the β-arrestin pathway. due to its functional selectivity for the g protein pathway, 6′-gnti functions as an antagonist of nonbiased kor agonists on the β-arrestin pathway. it is thought that 6′-gtni may be able to produce analgesia without dysphoria and with a lower incidence of tolerance.