isometheptene isometheptene isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels (arteries and veins). along with paracetamol and dichloralphenazone, it is one of the constituents of amidrine. isomethepteneclinical dataahfs/drugs.cominternational drug namesmedlineplusa601064routes ofadministrationoralatc codea03ax10 (who) identifiers iupac name n,6-dimethylhept-5-en-2-amine cas number503-01-5 ypubchem cid22297drugbankdb06706 ychemspider21106328 yuniiy7l24thh6tcomptox dashboard (epa)dtxsid9023172 echa infocard100.007.236 chemical and physical dataformulac9h19nmolar mass141.258 g·mol−13d model (jsmol)interactive image smiles cnc(c)ccc=c(c)c inchi inchi=1s/c9h19n/c1-8(2)6-5-7-9(3)10-4/h6,9-10h,5,7h2,1-4h3 ykey:xvquojberhhony-uhfffaoysa-n y (verify) chemistry isometheptene is a monounsaturated aliphatic secondary amine. mechanism of action isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. these compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors.