jwh-073 jwh-073 jwh-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the cb1 and cb2 cannabinoid receptors. it is somewhat selective for the cb1 subtype, with affinity at this subtype approximately 5x the affinity at cb2. the abbreviation jwh stands for john w. huffman, one of the inventors of the compound. jwh-073legal statuslegal status ca: schedule ii de: anlage ii (authorized trade only, not prescriptible) uk: class b us: schedule i illegal in latvia & poland identifiers iupac name naphthalen-1-yl-(1-butylindol-3-yl)methanone cas number208987-48-8 ypubchem cid10471670chemspider8647081 nuniibbx3bp2772comptox dashboard (epa)dtxsid20175042 echa infocard100.230.192 chemical and physical dataformulac23h21nomolar mass327.427 g·mol−13d model (jsmol)interactive image smiles ccccn1c=c(c2=cc=cc=c21)c(=o)c3=cc=cc4=cc=cc=c43 inchi inchi=1s/c23h21no/c1-2-3-15-24-16-21(19-12-6-7-14-22(19)24)23(25)20-13-8-10-17-9-4-5-11-18(17)20/h4-14,16h,2-3,15h2,1h3 nkey:vchhhsmpmlnvgs-uhfffaoysa-n n ny (what is this?) (verify) on 20 april 2009, jwh-073 was claimed by researchers at the university of freiburg to have been found in a "fertiliser" product called "forest humus", along with another synthetic cannabinoid (c8)-cp 47,497. these claims were confirmed in july 2009 when tests of spice product, seized after the legal ban on jwh-018 had gone into effect in germany, were shown to contain the unregulated compound jwh-073 instead. the analgesic effects of cannabinoid ligands, mediated by cb1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis. these compounds work by mimicking the body's naturally-produced endocannabinoid hormones such as 2-arachidonoylglycerol and anandamide, which are biologically active and can exacerbate or inhibit nerve signaling. as the cause is poorly understood in chronic pain states, more research and development must be done before we can realize the therapeutic potential of this class of biologic compounds. pharmacology jwh-073 has been shown to produce behavioral effects very similar to thc in animals. its effects are produced by binding and acting as an agonist to the cb1 and cb2 cannabinoid receptors. the cb1 receptor is found in the brain. jwh-073 bind to cb1 with a higher affinity than thc, suggesting that taking more too soon after the initial dose could lead to diminished effects. cb2 is found outside the brain, mostly in the immune system. the binding with cb2 receptors has been shown to be similar between jwh-073 and thc. a search in the literature yielded no published studies of the effects of jwh-073 in humans, but these studies in animals suggest with high probability that jwh-073 produces effects very similar to those of thc in humans. derivatives the 4'-methyl derivative of jwh-073 has been encountered as an ingredient of synthetic cannabis blends in germany and several other european countries since 2010. the 4'-methoxy derivative jwh-080 is also known to be a potent cannabinoid agonist and has been banned in some countries, though it is unclear if it has also been used in synthetic cannabis smoking blends. 4'-methyl-jwh-073 legal status united states