ruplizumab ruplizumab ruplizumab (trade name antova) is a humanized monoclonal antibody intended for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis. a study showed that the drug was associated with life-threatening thromboembolisms, while another study only found thrombocytopenia. ruplizumabmonoclonal antibodytypewhole antibodysourcehumanized (from mouse)targetcd154clinical datatrade namesantovaatc codenoneidentifierscas number220651-94-5 nchemspidernoneunii562jqf15gn ny (what is this?) (verify)