phenindamine phenindamine phenindamine (nolahist, thephorin) is an antihistamine and anticholinergic closely related to cyproheptadine. it was developed by hoffman-la roche in the late 1940s. it is used to treat symptoms of the common cold and allergies, such as sneezing, itching, rashes, and hives. its efficacy against some symptoms of opioid withdrawal was researched in the 1950s and 1960s in a number of countries; william s. burroughs' book junkie mentions this technique. like many other first-generation antihistamines, phenindamine has useful potentiating effects on many narcotic analgesics and is even more useful with those opioids which release histamine when in the body. phenindamineclinical dataahfs/drugs.commicromedex detailed consumer informationatc coder06ax04 (who) legal statuslegal status us: otc identifiers iupac name 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1h-indenopyridine cas number82-88-2 ypubchem cid11291drugbankdb01619 nchemspider10817 nunii772bq8ksstkeggd08353 ychemblchembl278398 ncomptox dashboard (epa)dtxsid0023452 echa infocard100.001.313 chemical and physical dataformulac19h19nmolar mass261.368 g·mol−13d model (jsmol)interactive image smiles cn(c1)ccc2=c1c(c3=c2c=cc=c3)c4=cc=cc=c4 inchi inchi=1s/c19h19n/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19h,11-13h2,1h3 nkey:isfhaysthmvojr-uhfffaoysa-n n ny (what is this?) (verify) nolahist was originally manufactured in the us by carnrick laboratories, and later by amarin pharmaceuticals. when that company ceased its american operations, its product line was acquired by valeant, but they declined to resume manufacturing nolahist. the last produced lot bore an expiration date of 10/2005, and the product is no longer available. phenindamine does exhibit optical isomerism as do other chemicals of its general type ranging from pethidine and alphaprodine to cyproheptadine to certain herbicides and other industrial chemicals; the. in the example at hand, the compound isophenidamine (60295-96-7 msds), which is inactive.