demecarium bromide demecarium bromide demecarium bromide, trade name humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. it is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma. not to be confused with decamethonium. demecarium bromideclinical datatrade nameshumorsolroutes ofadministrationtopical (ophthalmic solution)atc codes01eb04 (who) identifiers iupac name trimethyl-decyl]carbamoyl]oxyphenyl]ammonium dibromide cas number56-94-0 ypubchem cid5965drugbankdb00944 ychemspider5750 yunii61d5v4oktpkeggd00667 ychebichebi:4391 ychemblchembl1200514 ncomptox dashboard (epa)dtxsid6045240 echa infocard100.000.274 chemical and physical dataformulac32h52br2n4o4molar mass716.600 g·mol−13d model (jsmol)interactive image smiles ..o=c(oc1cccc(c1)(c)(c)c)n(ccccccccccn(c(=o)oc2cccc(c2)(c)(c)c)c)c inchi inchi=1s/c32h52n4o4.2brh/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26h,9-16,23-24h2,1-8h3;2*1h/q+2;;/p-2 ykey:yhkbudzecqdybr-uhfffaoysa-l y ny (what is this?) (verify) demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour). as demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol. commercially produced demecarium bromide solution, previously sold under the trade name humorsol, is no longer available, although solutions of demecarium can be compounded. use in dogs when administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs. high doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.