3-methyl-19-methyleneandrosta-3,5-dien-17β-ol 3-methyl-19-methyleneandrosta-3,5-dien-17β-ol 3-methyl-19-methyleneandrosta-3,5-dien-17β-ol is a synthetic, steroidal estrogen and a selective agonist of the erβ. it was discovered serendipitously and was the lead compound among a series of androsta-3,5-dienes as erβ ligands. its affinity (ic50) for the erβ was found to be 9 nm and it showed 62- and 160-fold binding selectivity for this receptor over the ar and the erα, respectively. the ec50 of the compound for the erβ was found to be 69 nm and its intrinsic activity was 92% (relative to that of estradiol). as such, it is a potent erβ agonist with high affinity and selectivity. 3-methyl-19-methyleneandrosta-3,5-dien-17β-olclinical dataother names3-methyl-19-methyleneandrosta-3,5-dien-17β-olidentifiers iupac name (8r,9s,10s,13s,14s,17s)-10-ethenyl-3,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1h-cyclopentaphenanthren-17-ol pubchem cid24896626chemspider23306322chemblchembl398456chemical and physical dataformulac21h30omolar mass298.470 g·mol−13d model (jsmol)interactive image smiles cc1=cc2=cc34cc(4(cc32(cc1)c=c)c)o inchi inchi=1s/c21h30o/c1-4-21-12-9-14(2)13-15(21)5-6-16-17-7-8-19(22)20(17,3)11-10-18(16)21/h4-5,13,16-19,22h,1,6-12h2,2-3h3/t16-,17-,18-,19-,20-,21-/m0/s1key:ppgvwcdlizeunc-pxqjohhusa-n