monastrol monastrol monastrol is a cell-permeable small molecule inhibitor discovered by thomas u. mayer in the lab of tim mitchison. monastrol was shown to inhibit the kinesin-5 (also known as kif11, kinesin eg5), a motor protein important for spindle bipolarity. monastrol names iupac name ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1h-pyrimidine-5-carboxylate other names monastrol identifiers cas number 329689-23-8 n 3d model (jsmol) interactive image chebi chebi:75382 y chembl chembl236789 y chemspider 2259791 y pubchem cid 2987927 comptox dashboard (epa) dtxsid10388124 inchi inchi=1s/c14h16n2o3s/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17h,3h2,1-2h3,(h2,15,16,20) nkey: lobcdghhhhghfa-uhfffaoysa-n yinchi=1/c14h16n2o3s/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17h,3h2,1-2h3,(h2,15,16,20)key: lobcdghhhhghfa-uhfffaoyao smiles ccoc(=o)c1=c(nc(=s)nc1c2=cc(=cc=c2)o)c properties chemical formula c14h16n2o3s molar mass 292.35344 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references mechanism of action monastrol inhibits eg5 monastrol binds to a long loop that is specific to the eg5 (also known as kif11 or kinesin-5) kinesin family, and allosterically inhibits atpase activity of the kinesin