aniracetam aniracetam aniracetam (brand names draganon, sarpul, ampamet, memodrin, referan), also known as n-anisoyl-2-pyrrolidinone, is a racetam which is sold in europe as a prescription drug. it is not approved by the food and drug administration for use in the united states as a prescription medication or dietary supplement. despite the fda's lack of approval, the drug is readily available over-the-counter in misbranded dietary supplements. aniracetamclinical datatrade namesampamet, memodrin, pergamidahfs/drugs.cominternational drug namesroutes ofadministrationby mouthatc coden06bx11 (who) legal statuslegal status au: s4 (prescription only) us: unapproved "new drug" (as defined by 21 u.s. code § 321(p)(1)). use in dietary supplements, food, or medicine is unlawful; otherwise uncontrolled. pharmacokinetic dataelimination half-life0.5 hoursidentifiers iupac name 1--2-pyrrolidinone cas number72432-10-1 npubchem cid2196iuphar/bps4133drugbankdb04599 ychemspider2111 yunii5l16lkn964keggd01883 ychebichebi:47943 ychemblchembl36994 ycomptox dashboard (epa)dtxsid5045128 echa infocard100.108.230 chemical and physical dataformulac12h13no3molar mass219.240 g·mol−13d model (jsmol)interactive image smiles o=c2n(c(=o)c1ccc(oc)cc1)ccc2 inchi inchi=1s/c12h13no3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7h,2-3,8h2,1h3 ykey:zxnrtkgtqjpijk-uhfffaoysa-n y ny (what is this?) (verify) pharmacology aniracetam has been shown to positively modulate the ampa receptor. when ingested orally aniracetam is quickly broken down via first pass hepatic metabolism. the primary metabolites of aniracetam are n-anisoyl-gaba, (70–80%), 2-pyrrolidinone and p-anisic acid (20–30%). there is some preliminary research suggesting that n-anisoyl-gaba and to a lesser degree p-ansic acid may contribute to the stimulatory effects of aniracetamin in rats. further work in rats suggets that n-anisoyl-gaba may contribute more to increasing acetylcholine release than aniracetam itself. plasma concentrations are generally in the 5–15 μg/l range for aniracetam and 5–15 mg/l range for n-anisoyl-gaba, a pharmacologically-active metabolite, during the first few hours after oral administration of the drug. these two plasma species may be measured by liquid chromatography-mass spectrometry. synthesis the drug was first made in the 1970s by hoffmann-la roche. synthesis can be accomplished by reacting 2-pyrrolidone with anisoyl chloride in the presence of triethylamine. alternatively, gamma-aminobutyric acid can react with anisoyl chloride. ring closure can be accomplished in the presence of thionyl chloride. legality europe aniracetam is available by prescription in greece (brand names memodrin and referan) and italy (brand name ampamet), where it is indicated for mental function disorders. australia aniracetam is a schedule 4 substance in australia under the poisons standard (february 2020). a schedule 4 substance is classified as "prescription only medicine, or prescription animal remedy – substances, the use or supply of which should be by or on the order of persons permitted by state or territory legislation to prescribe and should be available from a pharmacist on prescription."