cyp2b6 cyp2b6 cytochrome p450 2b6 is an enzyme that in humans is encoded by the cyp2b6 gene. cyp2b6 is a member of the cytochrome p450 group of enzymes. along with cyp2a6, it is involved with metabolizing nicotine, along with many other substances. cyp2b6available structurespdbortholog search: pdbe rcsb list of pdb id codes3ibd, 3qoa, 3qu8, 3ua5, 4i91, 4rql, 4rrt, 4zv8identifiersaliasescyp2b6, cpb6, cyp2b, cyp2b7, cyp2b7p, cypiib6, efvm, iib1, p450, cytochrome p450 family 2 subfamily b member 6, cytochrome p450 2b6external idsomim: 123930 mgi: 88598 homologene: 73894 genecards: cyp2b6 gene location (human)chr.chromosome 19 (human)band19q13.2start40,991,282 bpend41,018,398 bpgene location (mouse)chr.chromosome 7 (mouse)band7 a3|7 14.11 cmstart25,597,045 bpend25,626,049 bprna expression patternbgeehumanmouse (ortholog)top expressed inright lobe of liverkidney tubulemetanephric glomeruluskidneyjejunal mucosabronchial epithelial cellduodenuminternal globus pallidusrectumtibialis anterior muscletop expressed inright lung lobeduodenumlacrimal glandparotid glandsubmandibular glandintestinal villusskin of abdomenjejunumtracheaesophagusmore reference expression databiogpsn/agene ontologymolecular function iron ion binding arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen metal ion binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity steroid hydroxylase activity monooxygenase activity cellular component organelle membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum cytoplasm biological process steroid metabolic process epoxygenase p450 pathway cellular ketone metabolic process xenobiotic metabolic process organic acid metabolic process sources:amigo / quickgoorthologsspecieshumanmouseentrez155513088ensemblensg00000197408ensmusg00000030483uniprotp20813p12791refseq (mrna)nm_000767nm_009999refseq (protein)np_000758n/alocation (ucsc)chr 19: 40.99 – 41.02 mbchr 7: 25.6 – 25.63 mbpubmed searchwikidataview/edit humanview/edit mouse function this gene, cyp2b6, encodes a member of the cytochrome p450 superfamily of enzymes. the cytochrome p450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. this protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. the enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. gene transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, cyp2b7. both the gene and the pseudogene are located in the middle of a cyp2a pseudogene found in a large cluster of cytochrome p450 genes from the cyp2a, cyp2b and cyp2f subfamilies on chromosome 19q. cyp2b6 ligands following is a table of selected substrates, inducers and inhibitors of cyp2b6. inhibitors of cyp2b6 can be classified by their potency, such as: strong inhibitor being one that causes at least a 5-fold increase in the plasma auc values, or more than 80% decrease in clearance. moderate inhibitor being one that causes at least a 2-fold increase in the plasma auc values, or 50-80% decrease in clearance. weak inhibitor being one that causes at least a 1.25-fold but less than 2-fold increase in the plasma auc values, or 20-50% decrease in clearance. substratesinhibitorsinducers alfentanil (opioid analgesic) bupropion (antidepressant) clopidogrel cyclophosphamide (alkylating antineoplastic agent) efavirenz (nnrti) ifosfamide (alkylating antineoplastic agent) ketamine (dissociative anaesthetic) methadone (opiate replacement therapy) methoxetamine (dissociative agent, nmda receptor antagonist) nevirapine (nnrti) propofol (anesthetic) selegiline sertraline (antidepressant) sorafenib (protein kinase inhibitor) tamoxifen (serm) valproic acid (anticonvulsant) verapamil (minor/moderate sensitive substrates) strong: orphenadrine (anticholinergic) moderate: selegiline unspecified potency chlorpyrifos (insecticide) clopidogrel (antiplatelet) clotrimazole (antifungal) curcumin (supplement) (constituent of turmeric) ethinylestradiol (estrogen, contraceptive) fluoxetine (antidepressant) fluvoxamine (antidepressant) itraconazole (antifungal) ketoconazole (antifungal) memantine (nmda antagonist) paroxetine (antidepressant) raloxifene (serm) sertraline (antidepressant) thiotepa (anticancer) ticlopidine (antiplatelet) carbamazepine (anticonvulsant, mood stabilizer) phenobarbital (anticonvulsant ) phenytoin (antiepileptic) rifampicin (bactericidal) efavirenz (virostatic)