vindesine vindesine vindesine, also termed eldisine, is a semisynthetic vinca alkaloid derived from the flowering plant catharanthus roseus. like the natural (e.g. vinblastine and vincristine) and semisynthetic vinca alkaloids (e.g. vinorelbine and vinflunine) derived from this plant, vindesine is an inhibitor of mitosis that is used as a chemotherapy drug. by inhibiting mitosis, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. it is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as leukaemia, lymphoma, melanoma, breast cancer, and lung cancer. vindesineclinical dataahfs/drugs.commicromedex detailed consumer informationpregnancycategory au: d routes ofadministrationintravenousatc codel01ca03 (who) legal statuslegal status in general: ℞ (prescription only) pharmacokinetic dataprotein binding65-75%metabolismhepatic (cyp3a4-mediated)elimination half-life24 hoursexcretionbiliary and renalidentifiers iupac name methyl (5s,7s,9s)- 9-- 5-ethyl- 5-hydroxy- 1,4,5,6,7,8,9,10-octahydro- 2h- 3,7-methanoazacycloundecinoindole- 9-carboxylate cas number53643-48-4 ysulfate: 59917-39-4 ypubchem cid40839drugbankdb00309 ychemspider37302 yuniirsa8ko39whsulfate: cph2u7dndy ykeggd01769 ychebichebi:36373 ychemblchembl219146 ycomptox dashboard (epa)dtxsid6023739 echa infocard100.053.330 chemical and physical dataformulac43h55n5o7molar mass753.941 g·mol−13d model (jsmol)interactive image smiles o=c(oc)4(c2c(c1ccccc12)ccn3c(o)(cc)c(c3)c4)c5c(oc)cc6c(c5)89(n6c)(o)(c(=o)n)(o)7(/c=c\cn(78)cc9)cc inchi inchi=1s/c43h55n5o7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53h,6-7,13,15-18,21-24h2,1-5h3,(h2,44,50)/t25-,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1 ykey:hhjuwianjfbdht-kotlkjbcsa-n y (verify)