limbal nodule limbal nodule a limbal nodule is any nodular lesion at the limbus (junction of the cornea and sclera) of the eye. limbal nodulelimbusspecialtyophthalmology the differential diagnosis for a limbal nodule can include: pinguecula early pterygium foreign body / foreign body granuloma phlycten, an inflamed nodule of lymphoid tissue episcleritis scleritis granuloma limbal dermoid, a kind of choristoma (nb: in other organs dermoid can refer to a teratoma) malignant melanoma naevus