tetrahydrocannabutol tetrahydrocannabutol δ9-tetrahydrocannabutol (tetrahydrocannabinol-c4, thc-c4, δ9-thcb, (c4)-δ9-thc, butyl-thc) is a phytocannabinoid found in cannabis that is a homologue of tetrahydrocannabinol (thc), the main active component of cannabis. structurally, they are only different by the pentyl side chain being replaced by a butyl side chain. δ9-tetrahydrocannabinol-c4clinical dataatc codenoneidentifiers iupac name (−)-(6ar,10ar)-6,6,9-trimethyl-3-butyl-6a,7,8,10a-tetrahydro-6h-benzochromen-1-ol cas number60008-00-6 ypubchem cid6453891chemspider4956237 yuniilic9qas59uchemblchembl4437290comptox dashboard (epa)dtxsid10208712 chemical and physical dataformulac20h28o2molar mass300.442 g·mol−13d model (jsmol)interactive image smiles ccccc1=cc2=c(3c=c(cc3c(o2)(c)c)c)c(=c1)o inchi inchi=1s/c20h28o2/c1-5-6-7-14-11-17(21)19-15-10-13(2)8-9-16(15)20(3,4)22-18(19)12-14/h10-12,15-16,21h,5-9h2,1-4h3/t15-,16-/m1/s1 nkey:qhcqsgywgbdsiy-hzpdhxfcsa-n n ny (what is this?) (verify) pharmacology δ9-thcb, showed an affinity for the human cb1 (ki = 15 nm) and cb2 receptors (ki = 51 nm) comparable to that of δ9-thc. the formalin test in vivo was performed on δ9-thcb in order to reveal possible analgesic and anti-inflammatory properties. the tetrad test in mice showed a partial agonistic activity of δ9-thcb toward the cb1 receptor. thcb has rarely been isolated from cannabis samples, but appears to be less commonly present than thc or thcv. it is metabolized in a similar manner to thc. in an analysis by the university of rhode island on phytocannabinoids it was found that thc-butyl had the highest 3c-like protease inhibitor activity against covid-19 out of all the phytocannabinoids tested within that study but not as high as the antiviral drug gc376 (81% thcb vs 100% gc376). chemistry similarly to thc, it has 7 double bond isomers and 30 stereoisomers. the δ8 isomer is known as a synthetic cannabinoid under the code name jwh-130, and the ring-opened analogue cannibidibutol is also known. cannabidibutol (cbdb), 60113-11-3 jwh-130 (δ8-thcb), 51768-59-3 legality thcb is not scheduled internationally under the convention on psychotropic substances, but may be controlled under analogue law in some individual jurisdictions as a homologue of thc.