trioxsalen trioxsalen trioxsalen (trimethylpsoralen (tmp), trioxysalen (inn) or trisoralen) is a furanocoumarin and a psoralen derivative. it is obtained from several plants, mainly psoralea corylifolia. like other psoralens it causes photosensitization of the skin. it is administered either topically or orally in conjunction with uv-a (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. after photoactivation it creates interstrand cross-links in dna, which can cause programmed cell death unless repaired by cellular mechanisms. in research it can be conjugated to dyes for confocal microscopy and used to visualize sites of dna damage. the compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mrna sequence without affecting normal transcripts differing at even a single base pair. trioxsalen names preferred iupac name 2,5,9-trimethyl-7h-furobenzopyran-7-one identifiers cas number 3902-71-4 n 3d model (jsmol) interactive image chebi chebi:28329 y chembl chembl1475 y chemspider 5383 y drugbank db04571 y echa infocard 100.021.327 kegg d01034 y pubchem cid 5585 unii y6uy8ov51t y comptox dashboard (epa) dtxsid3023716 inchi inchi=1s/c14h12o3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6h,1-3h3 ykey: fmhhvuleaztjma-uhfffaoysa-n yinchi=1/c14h12o3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6h,1-3h3key: fmhhvuleaztjma-uhfffaoyaf smiles cc1cc2c(o1)c(c)c1c(c2)c(c)cc(=o)o1 properties chemical formula c14h12o3 molar mass 228.24328 pharmacology atc code d05ad01 (who) d05ba01 (who) except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references trioxsalen (abbreviated as tmp) activated by uv-a exposure is commonly used in genetics research as an experimental mutagen. uv/tmp generates small deletions (~1-3 kbp), but all base transitions and transversions can also be obtained.