metacycline metacycline metacycline or methacycline is a tetracycline antibiotic. it is used as a precursor in the industrial synthesis of doxycycline hyclate. not to be confused with meticillin or meclocycline. metacyclineclinical dataahfs/drugs.cominternational drug namesatc codej01aa05 (who) identifiers iupac name (2z,4s,4ar,5s,5ar,12as)-2--4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2h,4h,5h)-trione cas number914-00-1 npubchem cid54675785chemspider10468596 yuniiir235i7c5pchemblchembl249837 nniaid chemdb001301comptox dashboard (epa)dtxsid2023272 echa infocard100.011.834 chemical and physical dataformulac22h22n2o8molar mass442.424 g·mol−13d model (jsmol)interactive image smiles nc(=o)c=3c(=o)4(o)c(\o)=c2\c(=o)c1c(o)cccc1c(=c)2(o)4(n(c)c)c=3o inchi inchi=1s/c22h22n2o8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-6,10,14-15,17,25,27-29,32h,1h2,2-3h3,(h2,23,31)/t10-,14-,15+,17+,22+/m1/s1 ykey:mhigbkbjsqvxnh-iwvlmiassa-n y ny (what is this?) (verify) it has been found to act as an agonist of the human pregnane x receptor ligand-binding domain and to induce cyp3a4 expression in vitro.