1957–1958 influenza pandemic 1957–1958 influenza pandemic the 1957–1958 asian flu pandemic was a global pandemic of influenza a virus subtype h2n2 that originated in guizhou in southern china. the number of excess deaths caused by the pandemic is estimated to be 1–4 million around the world (1957–1958 and probably beyond), making it one of the deadliest pandemics in history. a decade later, a reassorted viral strain h3n2 further caused the hong kong flu pandemic (1968–1969). 1957–1958 influenza pandemicdiseaseinfluenzavirus strainstrains of a/h2n2locationworldwidefirst reportedguizhou, chinadate1957–1958deaths1–4 million (estimates) influenza (flu) types avian a/h5n1 subtype canine equine swine a/h1n1 subtype vaccines 2009 pandemic pandemrix live attenuated seasonal flu vaccine brands treatment amantadine baloxavir marboxil laninamivir oseltamivir peramivir rimantadine umifenovir zanamivir pandemics 1889-1890 russian flu 1918 spanish flu 1957-1958 asian flu 1968 hong kong flu 1977 russian flu 2009 swine flu outbreaks 1976 swine flu 2006 h5n1 india 2007 australian equine 2007 bernard matthews h5n1 2008 west bengal 2015 united states h5n2 outbreak 2020–2022 h5n8 outbreak