familial isolated vitamin e deficiency familial isolated vitamin e deficiency familial isolated vitamin e deficiency or ataxia with vitamin e deficiency (aved) is a rare autosomal recessive neurodegenerative disease. symptoms are similar to those of friedreich ataxia. familial isolated vitamin e deficiencyother namesataxia with vitamin e deficiencyfamilial isolated vitamin e deficiency has an autosomal recessive pattern of inheritance.specialtyneurology treatmenthigh-dose oral vitamin e supplementation cause familial isolated vitamin e deficiency is caused by mutations in the gene for a-tocopherol transfer protein. symptoms manifest late childhood to early teens. diagnosis treatment treatment includes vitamin e therapy, where lifelong high-dose oral vitamin e supplementation is prescribed to maintain plasma vitamin e concentrations and monitoring vitamin e levels in blood plasma.