btrx-335140 btrx-335140 btrx-335140, also known by its other developmental code names btrx-140, cym-53093, and nmra-140, is an opioid antagonist medication which is under development for the treatment of depression. it is specifically a selective κ-opioid receptor antagonist and is under development for major depressive disorder. as of february 2020, btrx-335140 is in phase 2 clinical trials for this indication. btrx-335140clinical dataother namesbtrx-140; cym-53093; nmra-140identifiers iupac name 1--n-(oxan-4-yl)piperidin-4-amine cas number2244614-14-8pubchem cid137434175chemspider78316413uniixk5ilz28kichemical and physical dataformulac25h32fn5o2molar mass453.562 g·mol−13d model (jsmol)interactive image smiles ccc1=cc2=c(c(=c(n=c2c(=c1)f)n3ccc(cc3)nc4ccocc4)c5=nc(=no5)c)c inchi inchi=1s/c25h32fn5o2/c1-4-17-13-20-15(2)22(25-27-16(3)30-33-25)24(29-23(20)21(26)14-17)31-9-5-18(6-10-31)28-19-7-11-32-12-8-19/h13-14,18-19,28h,4-12h2,1-3h3key:cqojhajwcdjeat-uhfffaoysa-n