dilated cardiomyopathy dilated cardiomyopathy dilated cardiomyopathy (dcm) is a condition in which the heart becomes enlarged and cannot pump blood effectively. symptoms vary from none to feeling tired, leg swelling, and shortness of breath. it may also result in chest pain or fainting. complications can include heart failure, heart valve disease, or an irregular heartbeat. dilated cardiomyopathyother namescongestive cardiomyopathy,idiopathic cardiomyopathy,primary cardiomyopathymouse heart slice showing dilated cardiomyopathyspecialtycardiologysymptomsfeeling tired, leg swelling, shortness of breath, chest pain, faintingcomplicationsheart failure, heart valve disease, irregular heartbeatusual onsetmiddle agetypestachycardia-induced, otherscausesgenetics, alcohol, cocaine, certain toxins, complications of pregnancy, in many cases the cause remains unclear, certain infectionsdiagnostic methodsupported by electrocardiogram, chest x-ray, echocardiogramdifferential diagnosiscoronary artery disease, heart valve disease, pulmonary embolism, other cardiomyopathytreatmentlifestyle changes, medications, implantable cardioverter defibrillator, cardiac resynchronization therapy (crt), heart transplantmedicationace inhibitor, beta blocker, diuretic, blood thinnersprognosisfive-year survival rate ~50%frequency1 in 2500 causes include genetics, alcohol, cocaine, certain toxins, complications of pregnancy, and certain infections. coronary artery disease and high blood pressure may play a role, but are not the primary cause. in many cases the cause remains unclear. it is a type of cardiomyopathy, a group of diseases that primarily affects the heart muscle. the diagnosis may be supported by an electrocardiogram, chest x-ray, or echocardiogram. in those with heart failure, treatment may include medications in the ace inhibitor, beta blocker, and diuretic families. a low salt diet may also be helpful. in those with certain types of irregular heartbeat, blood thinners or an implantable cardioverter defibrillator may be recommended. cardiac resynchronization therapy (crt) may be necessary. if other measures are not effective a heart transplant may be an option in some. about 1 per 2,500 people is affected. it occurs more frequently in men than women. onset is most often in middle age. five-year survival rate is about 50%. it can also occur in children and is the most common type of cardiomyopathy in this age group. signs and symptoms main article: heart failure § signs and symptoms dilated cardiomyopathy develops insidiously, and may not initially cause symptoms significant enough to impact on quality of life. nevertheless, many people experience significant symptoms. these might include: shortness of breath syncope (fainting) angina, but only in the presence of ischemic heart disease a person who has dilated cardiomyopathy may have an enlarged heart, with pulmonary edema and an elevated jugular venous pressure and a low pulse pressure. signs of mitral and tricuspid regurgitation may be present. causes although in many cases no cause is apparent, dilated cardiomyopathy is probably the result of damage to the myocardium produced by a variety of toxic, metabolic, or infectious agents. in many cases the cause remains unclear. it may be due to fibrous change of the myocardium from a previous myocardial infarction. or, it may be the late sequelae of acute viral myocarditis, such as with coxsackie b virus and other enteroviruses possibly mediated through an immunologic mechanism. specific autoantibodies are detectable in some cases. other causes include: chagas disease, due to trypanosoma cruzi. this is the most common infectious cause of dilated cardiomyopathy in latin america pregnancy: dilated cardiomyopathy occurs late in gestation or several weeks to months postpartum as a peripartum cardiomyopathy. it is reversible in half of cases. alcohol use disorder (alcoholic cardiomyopathy) non-alcoholic toxic insults include administration of certain chemotherapeutic agents, in particular doxorubicin (adriamycin), and cobalt. thyroid disease inflammatory diseases such as sarcoidosis and connective tissue diseases tachycardia-induced cardiomyopathy muscular dystrophy tuberculosis: 1 to 2% of tb cases. autoimmune mechanisms thiamine deficiency recent studies have shown that those subjects with an extremely high occurrence (several thousands a day) of premature ventricular contractions (extrasystole) can develop dilated cardiomyopathy. in these cases, if the extrasystole are reduced or removed (for example, via ablation therapy) the cardiomyopathy usually regresses. genetics genetic associations with dilated cardiomyopathy type omim gene locus cmd1a 115200 lmna 1q21 cmd1b 600884 unknown (tmod1 candidate) 9q13 cmd1c 601493 ldb3 10q22-q23 cmd1d 601494 tnnt2 1q32 cmd1e 601154 scn5a 3p cmd1f 602067 6q23 cmd1g 604145 ttn 2q31 cmd1h 604288 2q14-q22 cmd1i 604765 des cmd1k 605582 6q12-q16 cmd1l 606685 sgcd 5q33 cmd1m 607482 csrp3 11p15.1 cmd1n 607487 tcap 17q12 cmd1o 608569 abcc9 12p12.1 cmd1p 609909 pln 6q22.1 cmd1q 609915 7q22.3-q31.1 cmd1r actc 15q14 cmd1s myh7 14q12 cmd1t tmpo 12q22 cmd1u psen1 14q24.3 cmd1v psen2 1q31-q42 cmd1w 611407 vcl 10q22-q23 cmd1x fcmd 9q31 cmd1y 611878 tpm1 15q22.1 cmd1z 611879 tnnc1 3p21.3-p14.3 cmd1aa 612158 actn2 1q42-q43 cmd2a 611880 tnni3 19q13.4 cmd3a 300069 taz xq28 cmd3b 302045 dmd xp21.2 alpk3 15q25.3 about 25–35% of affected individuals have familial forms of the disease, with most mutations affecting genes encoding cytoskeletal proteins, while some affect other proteins involved in contraction. the disease is genetically heterogeneous, but the most common form of its transmission is an autosomal dominant pattern. autosomal recessive (as found, for example, in alström syndrome), x-linked (as in duchenne muscular dystrophy), and mitochondrial inheritance of the disease is also found. some relatives of those affected by dilated cardiomyopathy have preclinical, asymptomatic heart-muscle changes. other cytoskeletal proteins involved in dcm include α-cardiac actin, desmin, and the nuclear lamins a and c. mitochondrial deletions and mutations presumably cause dcm by altering myocardial atp generation. kayvanpour et al. performed 2016 a meta-analysis with the largest dataset available on genotype-phenotype associations in dcm and mutations in lamin (lmna), phospholamban (pln), rna binding motif protein 20 (rbm20), cardiac myosin binding protein c (mybpc3), myosin heavy chain 7 (myh7), cardiac troponin t 2 (tnnt2), and cardiac troponin i (tnni3). they also reviewed recent studies investigating genotype-phenotype associations in dcm patients with titin (ttn) mutations. lmna and pln mutation carriers showed a high prevalence of cardiac transplantation and ventricular arrhythmia. dysrhythmias and sudden cardiac death (scd) was shown to occur even before the manifestation of dcm and heart failure symptoms in lmna mutation carriers. pathophysiology illustration of a normal heart vs. heart with dilated cardiomyopathy the progression of heart failure is associated with left ventricular remodeling, which manifests as gradual increases in left ventricular end-diastolic and end-systolic volumes, wall thinning, and a change in chamber geometry to a more spherical, less elongated shape. this process is usually associated with a continuous decline in ejection fraction. the concept of cardiac remodeling was initially developed to describe changes that occur in the days and months following myocardial infarction. compensation effects as dcm progresses, two compensatory mechanisms are activated in response to impaired myocyte contractility and reduced stroke volume: frank-starling law neurohormonal feedback, via activation of the sympathetic nervous system and the renin-angiotensin system. these responses initially compensate for decreased cardiac output and maintain those with dcm as asymptomatic. eventually, however, these mechanisms become detrimental, intravascular volume becomes too great, and progressive dilatation leads to heart failure symptoms. computational models cardiac dilatation is a transversely isotropic, irreversible process resulting from excess strains on the myocardium. a computation model of volumetric, isotropic, and cardiac wall growth predicts the relationship between cardiac strains (e.g. volume overload after myocardial infarction) and dilation using the following governing equations: f = f e ⋅ f g \cdot f^\,} where f e is elastic volume stretch that is reversible and f g is irreversible, isotropic volume growth described by: f g = i + [ λ g − 1 ] f 0 ⊗ f 0 =\mathbb +f_\otimes f_\,} where f 0 is a vector, which points along a cardiomyocyte's long axis and λ g is the cardiomyocyte stretch due to growth. the total cardiomyocyte growth is given by: λ = λ e ⋅ f λ g \cdot f\lambda ^\,} the above model reveals a gradual dilation of the myocardium, especially the ventricular myocardium, to support the blood volume overload in the chambers. dilation manifests itself in an increase in total cardiac mass and cardiac diameter. cardiomyocytes reach their maximum length of 150 μ m in the endocardium and 130 μ m in the epicardium by the addition of sarcomeres. due to the increase in diameter, the dilated heart appears spherical in shape, as opposed the elliptical shape of a healthy human heart. in addition, the ventricular walls maintain the same thickness, characteristic of pathophysiological cardiac dilation. valvular effects as the ventricles enlarge, both the mitral and tricuspid valves may lose their ability to come together properly. this loss of coaptation may lead to mitral and tricuspid regurgitation. as a result, those with dcm are at increased risk of atrial fibrillation. furthermore, stroke volume is decreased and a greater volume load is placed on the ventricle, thus increasing heart failure symptoms. diagnosis serial 12-lead ecgs from a 49-year-old black man with cardiomyopathy. (top): sinus tachycardia (rate about 101/min) with lbbb accompanied by rad (here about 108°). frequent multifocal pvcs (both singly and in pairs) and left atrial enlargement. (bottom): same patient about 5 months later status-post orthotopic heart transplant. dilated cardiomyopathy on cxr dilated cardiomyopathy on ct generalized enlargement of the heart is seen upon normal chest x-ray. pleural effusion may also be noticed, which is due to pulmonary venous hypertension. the electrocardiogram often shows sinus tachycardia or atrial fibrillation, ventricular arrhythmias, left atrial enlargement, and sometimes intraventricular conduction defects and low voltage. when left bundle-branch block (lbbb) is accompanied by right axis deviation (rad), the rare combination is considered to be highly suggestive of dilated or congestive cardiomyopathy. echocardiogram shows left ventricular dilatation with normal or thinned walls and reduced ejection fraction. cardiac catheterization and coronary angiography are often performed to exclude ischemic heart disease. genetic testing can be important, since one study has shown that gene mutations in the ttn gene (which codes for a protein called titin) are responsible for "approximately 25% of familial cases of idiopathic dilated cardiomyopathy and 18% of sporadic cases." the results of the genetic testing can help the doctors and patients understand the underlying cause of the dilated cardiomyopathy. genetic test results can also help guide decisions on whether a patient's relatives should undergo genetic testing (to see if they have the same genetic mutation) and cardiac testing to screen for early findings of dilated cardiomyopathy. cardiac magnetic resonance imaging (cardiac mri) may also provide helpful diagnostic information in patients with dilated cardiomyopathy. treatment medical therapy drug therapy can slow down progression and in some cases even improve the heart condition. standard therapy may include salt restriction, ace inhibitors, diuretics, and beta blockers. anticoagulants may also be used for antithrombotic therapy. there is some evidence for the benefits of coenzyme q10 in treating heart failure. electrical treatment artificial pacemakers may be used in patients with intraventricular conduction delay, and implantable cardioverter-defibrillators in those at risk of arrhythmia. these forms of treatment have been shown to prevent sudden cardiac death, improve symptoms, and reduce hospitalization in patients with systolic heart failure. in addition, an implantable cardioverter-defibrillator should be considered as a therapeutic option for the primary prevention of sudden cardiac death in patients with a confirmed lmna mutation responsible for dilated cardiomyopathy disease phenotype and clinical risk factors. a novel risk score calculator has been developed that allows calculation of risk of sustained ventricular arrhythmia in the next 5 years in patients with dcm https://www.ikard.pl/sva/ surgical treatment in patients with advanced disease who are refractory to medical therapy, heart transplantation may be considered. for these people, 1-year survival approaches 90% and over 50% survive greater than 20 years. epidemiology although the disease is more common in african-americans than in caucasians, it may occur in any patient population. research directions therapies that support reverse remodeling have been investigated, and this may suggests a new approach to the prognosis of cardiomyopathies (see ventricular remodeling). animals in some types of animals, both a hereditary and acquired version of dilated cardiomyopathy has been documented. dogs dilated cardiomyopathy is a heritable disease in some dog breeds, including the boxer, dobermann, great dane, irish wolfhound, and st bernard. treatment is based on medication, including ace inhibitors, loop diuretics, and phosphodiesterase inhibitors. an acquired variation of dilated cardiomyopathy describing a link between certain diets was discovered in 2019 by researchers at university of california, davis school of veterinary medicine who published a report on the development of dilated cardiomyopathy in dog breeds lacking the genetic predisposition, particularly in golden retrievers. the diets associated with dcm were described as "beg" (boutique, exotic-ingredient, and/or grain-free) dog foods, as well as legume-rich diets. for treating diet-related dcm, food changes, taurine and carnitine supplementation may be indicated even