guizar–vasquez–sanchez–manzano syndrome guizar–vasquez–sanchez–manzano syndrome guizar-vasquez-sanchez-manzano syndrome is an extremely rare genetic and congenital disorder that is characterized by facial dysmorphisms (more specifically, chubby cheeks, mild frontal bossing, a beaked nose with an accompanying low nasal bridge, malar hypoplasia, peculiar philtrums and upper lips), pectus carinatum, and joint hypermobility. only 2 cases have ever been reported in medical literature, with both of those cases coming from siblings of the same family. guizar-vazquez-sanchez-manzano syndromeother namesdysmorphism-pectus carinatum-joint laxity syndromespecialtymedical geneticsfrequencyextremely rare, only two cases have ever been reported