steatocystoma simplex steatocystoma simplex steatocystoma simplex is a skin condition characterized by a skin lesion that occurs with equal frequency in adult women and men, and is typically found on the face, trunk, or extremities.: 679 it is related to steatocystoma multiplex. steatocystoma simplexother namessimple sebaceous duct cyst, solitary steatocystomamicrograph of a steatocystoma showing the characteristic corrugated eosinophilic lining. h&e stainspecialtydermatology relative incidence of cutaneous cysts. steatocystoma is labeled at right.