pregnenolone sulfate pregnenolone sulfate pregnenolone sulfate (ps, pregs) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone. it is known to have cognitive and memory-enhancing, antidepressant, anxiogenic, and proconvulsant effects. pregnenolone sulfate names iupac name 20-oxopregn-5-en-3β-yl hydrogen sulfate systematic iupac name (1s,3as,3bs,7s,9ar,9bs,11as)-1-acetyl-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1h-cyclopentaphenanthren-7-yl hydrogen sulfate other names pregn-sulf; pregnenolone monosulfate; pregnenolone hydrogen sulfate; pregnenolone 3β-sulfate; 5-pregnen-3β-ol-20-one sulfate; (3β)-3-(sulfooxy)pregn-5-en-20-one; 5-pregnen-3β-sulfate-20-one; 20-oxo-5-pregnen-3β-yl sulfate identifiers cas number 1247-64-9 y 3d model (jsmol) interactive image chembl chembl141573 n chemspider 94802 n iuphar/bps 4290 pubchem cid 105074 unii 04y4d91rg0 y comptox dashboard (epa) dtxsid60924910 inchi inchi=1s/c21h32o5s/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19h,5-12h2,1-3h3,(h,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 nkey: dijbbuiowggqop-qgvnflhtsa-n ninchi=1/c21h32o5s/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19h,5-12h2,1-3h3,(h,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1key: dijbbuiowggqop-qgvnflhtbx smiles cc(=o)1cc21(cc32cc=c43(cc(c4)os(=o)(=o)o)c)c properties chemical formula c21h32o5s molar mass 396.54 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references biological activity pregnenolone sulfate is a neurosteroid with excitatory effects in the brain, acting as a potent negative allosteric modulator of the gabaa receptor and a weak positive allosteric modulator of the nmda receptor. to a lesser extent, it also acts as a negative allosteric modulator of the ampa, kainate, and glycine receptors, and may interact with the nach receptors as well. in addition to its effects on ligand-gated ion channels, pregnenolone sulfate is an agonist of the sigma receptor, as well as an activator of the trpm1 and trpm3 channels. it may also interact with potassium channels and voltage-gated sodium channels and has been found to inhibit voltage-gated calcium channels. biochemistry steroidogenesis, with pregnenolone, the precursor of pregnenolone sulfate, at top left. biosynthesis pregnenolone sulfate is synthesized from pregnenolone via sulfation. pregnenolone itself is produced from cholesterol via cholesterol side-chain cleavage enzyme. chemistry