cgs-20625 cgs-20625 cgs-20625 is an anxiolytic drug used in scientific research. it has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. it produces anxiolytic and anticonvulsant effects, but with no sedative effects even at high doses, and no significant muscle relaxant effects. it is orally active in humans, but with relatively low bioavailability. cgs-20625clinical dataroutes ofadministrationby mouthatc codenonepharmacokinetic databioavailability41%identifiers iupac name 5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-cycloheptapyrazolopyridin-3(2h)-one cas number111205-55-1 ypubchem cid163844chemspider143700 nuniik9q4r9s81ocomptox dashboard (epa)dtxsid30912046 chemical and physical dataformulac18h19n3o2molar mass309.369 g·mol−13d model (jsmol)interactive image smiles coc1=cc=c(c=c1)n2c(=o)c3=cn=c4cccccc4=c3n2 inchi inchi=1s/c18h19n3o2/c1-23-13-9-7-12(8-10-13)21-18(22)15-11-19-16-6-4-2-3-5-14(16)17(15)20-21/h7-11,20h,2-6h2,1h3 nkey:ublxqfifwuevgj-uhfffaoysa-n n ny (what is this?) (verify) cgs-20625 is a positive allosteric modulator at several gabaa receptors types. due to its alicyclic moiety potency at γ1 subunit, containing receptor types is more pronounced for cgs-20625 compared to benzodiazepines. γ1 subunits are expressed at higher levels in the central amygdala.