pregnenolone (medication) pregnenolone (medication) pregnenolone, sold under the brand name enelone among others, is a medication and supplement as well as a naturally occurring and endogenous steroid. it is described as a neurosteroid and anti-inflammatory drug and was used in the treatment of rheumatoid arthritis and soft-tissue rheumatism in the 1950s but is no longer used today. pregnenolone can be taken by mouth, as a topical medication, or by injection into muscle. not to be confused with pregnanolone or pregneninolone. this article is about pregnenolone as a medication and supplement. for its role as a hormone, see pregnenolone. pregnenoloneclinical datatrade namesarthenolone, bina-skin, enelone, natolone, pregneton, prenolone, regnosone, sharmone, skinostelonother namesp5; 5-pregnenolone; δ5-pregnene-3β-ol-20-one; pregn-5-en-3β-ol-20-one; nsc-1616ahfs/drugs.cominternational drug namesroutes ofadministrationby mouth, transdermaldrug classneurosteroid; anti-inflammatoryatc codenonelegal statuslegal status in general: over-the-counter (otc) identifiers iupac name 1-phenanthren-17-yl]ethanone cas number145-13-1 ypubchem cid8955iuphar/bps2376drugbankdb02789 ychemspider8611 yunii73r90f7mq8keggd00143chebichebi:16581 ychemblchembl253363 ychemical and physical dataformulac21h32o2molar mass316.485 g·mol−13d model (jsmol)interactive image smiles cc(=o)1cc21(cc32cc=c43(cc(c4)o)c)c inchi inchi=1s/c21h32o2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23h,5-12h2,1-3h3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 ykey:ornbqbciokfoeo-qgvnflhtsa-n y (verify) pregnenolone is promoted online with false claims that it can treat a variety of health conditions including cancer, arthritis and multiple sclerosis. medical uses pregnenolone was approved for use as a pharmaceutical medication in the treatment of rheumatoid arthritis and soft-tissue rheumatism in the 1950s. it is no longer used today. available forms pregnenolone acetate was available as enelone in the form of 100 mg oral tablets and as a 100 mg/ml crystalline aqueous suspension in 10 ml vials. pharmacology