gad67 in cell cultures. some of the current dnmt inhibitors, however, like zebularine and procainamide, do not cross the blood brain barrier and would not prove as effective a treatment. while dnmt inhibitors would prevent the addition of a methyl group, there is also research done on dna demethylate inducers, which would pharmacologically induce the removal of methyl groups. current antipsychotic drugs, like clozapine and sulpiride, have been shown to also induce demethylation.