mast cell activation syndrome mast cell activation syndrome mast cell activation syndrome (mcas) is a term referring to one of two types of mast cell activation disorder (mcad); the other type is idiopathic mcad. mcas is an immunological condition in which mast cells inappropriately and excessively release chemical mediators, resulting in a range of chronic symptoms, sometimes including anaphylaxis or near-anaphylaxis attacks. primary symptoms include cardiovascular, dermatological, gastrointestinal, neurological and respiratory problems. not to be confused with mastocytosis. mast cell activation syndromespecialtyimmunology (allergy) mcas is an umbrella term that describes a set of symptoms; it is not a specific diagnosis. multiple diagnostic schemes for mcas have been proposed. mcas has been increasingly over-diagnosed or misdiagnosed. signs and symptoms mcas is an inflammatory condition that affects multiple systems. mcas can present with a wide range of symptoms in multiple body systems, these symptoms may range from digestive discomfort to chronic pain, mental issues as well as an anaphylactic reaction. symptoms typically wax and wane over time, varying in severity and duration. many signs and symptoms are the same as those for mastocytosis, because both conditions result in too many mediators released by mast cells. it has many overlapping characteristics with recurrent idiopathic anaphylaxis, although there are distinguishing symptoms, specifically hives and angioedema. the condition may be mild until exacerbated by stressful life events, or symptoms may develop and slowly trend worse with time. mcas symptoms are common in long covid. common symptoms include: dermatological flushing hives easy bruising either a reddish or a pale complexion itchiness burning feeling dermatographism cardiovascular lightheadedness, dizziness, non-cardiac chestpain, presyncope, syncope, arrhythmia, tachycardia gastrointestinal diarrhea and/or constipation, cramping, intestinal discomfort nausea, vomiting, acid reflux swallowing difficulty, throat tightness neuropsychiatric brain fog headache fatigue/lethargy lack of concentration mild cognitive problems sleep disturbances respiratory congestion, coughing, wheezing systemic anaphylaxis causes there are many causes of mast cell activation, including allergy. genetics may play a role. symptoms of mcas are caused by excessive chemical mediators released by mast cells. mediators include leukotrienes, histamines, prostaglandin, and tryptase. pathophysiology mast cell activation can be localized or systemic, but a diagnosis of mcas requires systemic symptoms. some examples of tissue specific consequences of mast cell activation include urticaria, allergic rhinitis, and wheezing. systemic mast cell activation presents with symptoms involving two or more organ systems (skin: urticaria, angioedema, and flushing; gastrointestinal: nausea, vomiting, diarrhea, and abdominal cramping; cardiovascular: hypotensive syncope or near syncope and tachycardia; respiratory: wheezing; naso-ocular: conjunctival injection, pruritus, and nasal stuffiness). this can result from the release of mediators from a specific site, such as the skin or mucosal tissue, or activation of mast cells around the vasculature. diagnosis mcas is often difficult to identify due to the heterogeneity of symptoms and the "lack of flagrant acute presentation". many of the numerous symptoms are non-specific in nature. diagnostic criteria were proposed in 2010 and revised in 2019. mast cell activation was assigned an icd-10 code (d89.40, along with subtype codes d89.41-43 and d89.49) in october 2016. although different diagnostic criteria are published, a commonly used strategy to diagnose patients is to use all three of the following: symptoms consistent with chronic/recurrent mast cell release: recurrent abdominal pain, diarrhea, flushing, itching, nasal congestion, coughing, chest tightness, wheezing, lightheadedness (usually a combination of some of these symptoms is present) laboratory evidence of mast cell mediator (elevated serum tryptase, n-methyl histamine, prostaglandin d2 or 11-beta- prostaglandin f2 alpha, leukotriene e4 and others) improvement in symptoms with the use of medications that block or treat elevations in these mediators the world health organization has not published diagnostic criteria. treatment common pharmacological treatments include: mast cell stabilizers, including cromolyn sodium and natural stabilizers such as quercetin h1-antihistamines, such as cetirizine or ketotifen or fexofenadine or loratadine h2-antihistamines, such as ranitidine or famotidine antileukotrienes, such as montelukast or zileuton as well as natural products (e.g., curcumin or st. john's wort extracts) nonsteroidal anti-inflammatory drugs, including aspirin can be very helpful in reducing inflammation in some patients, while others can have dangerous reactions prognosis the prognosis of mcas is uncertain. history the condition was hypothesized by the pharmacologists oates and roberts of vanderbilt university in 1991, and named in 2007, following a build-up of evidence featured in papers by sonneck et al. and akin et al.,