antiglucocorticoid antiglucocorticoid an antiglucocorticoid is a drug which reduces glucocorticoid activity in the body. they include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. they are used to treat cushing's syndrome. antiglucocorticoiddrug classmifepristone, an antiglucocorticoid that is used in the treatment of cushing's syndrome.class identifierssynonymsglucocorticoid antagonist; cortisol antagonist; anticorticosteroidusecushing's syndrome, othersbiological targetglucocorticoid receptorchemical classsteroidsin wikidata antiglucocorticoids could be effective antidepressants for a subset of specific mood disorders, but their use is limited by side effects.