benidipine benidipine benidipine is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). it is a triple l-, t-, and n-type calcium channel blocker. it is reno- and cardioprotective. benidipineclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationby mouthatc codec08ca15 (who) identifiers iupac name o5-methyl o3- 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate cas number105979-17-7 ypubchem cid656668chemspider571013 nunii4g9t91js7echemblchembl2218858 nchemical and physical dataformulac28h31n3o6molar mass505.571 g·mol−13d model (jsmol)interactive image smiles (=o)c1cccc(c1)4c(/c(=o)oc)=c(\n\c(=c4\c(=o)o3cccn(cc2ccccc2)c3)c)c inchi inchi=1s/c28h31n3o6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29h,8,13-14,16-17h2,1-3h3/t23-,26-/m1/s1 nkey:qzvnqolplywlhq-zeqkjwhpsa-n n ny (what is this?) (verify) it was patented in 1981 and approved for medical use in 1991. dosing benidipine is dosed as 2–8 mg once daily. mechanism benidipine is a calcium channel blocker. benidipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid. names other names include benidipinum or benidipine hydrochloride. benidipine is sold as coniel by kyowa hakko kogyo. benidipine is initially licensed for use in japan and selected southeast asian countries and later in turkey, where it is sold as 4 mg tablets.