skin thickening which may prevent some medications from effectively working to treat the chronic itch. senile pruritus can have a significant impact on the quality of life. elderly people with this condition may feel more anxious or stressed due to their physical disposition. the urge to itch may feel so severe that it could affect their ability to sleep. there are challenges that come with approaching treatment for senile pruritus because of the number of potential underlying causes physicians have to narrow down along with potential intolerances to certain therapies with people ages 65 or older. even certain ongoing medication usage can have a link to pruritus triggering in the elderly, but current treatments should not be the only thing to be wary of. a lot of it has to do with features that come with the ageing process whether it be systemic, psychogenic, or cutaneous conditions. every treatment used with the elderly is managed with caution because of potential risks involved, such as higher toxicity compared to younger individuals since medications are metabolized differently.