jwh-007 jwh-007 jwh-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the cb1 and cb2 receptors. it was first reported in 1994 by a group including the noted cannabinoid chemist john w. huffman. it was the most active of the first group of n-alkyl naphoylindoles discovered by the team led by john w huffman, several years after the family was initially described with the discovery of the n-morpholinylethyl compounds pravadoline (win 48,098), jwh-200 (win 55,225) and win 55,212-2 by the sterling winthrop group. several other n-alkyl substituents were found to be active by huffman's team including the n-butyl, n-hexyl, 2-heptyl, and cyclohexylethyl groups, but it was subsequently determined that the 2-methyl group on the indole ring is not required for cb1 binding, and tends to increase affinity for cb2 instead. consequently, the 2-desmethyl derivative of jwh-007, jwh-018, has slightly higher binding affinity for cb1, with an optimum binding of 9.00 nm at cb1 and 2.94 nm at cb2, and jwh-007 displayed optimum binding of 9.50 nm at cb1 and 2.94 nm at cb2. jwh-007legal statuslegal status ca: schedule ii de: anlage ii (authorized trade only, not prescriptible) uk: class b us: schedule i identifiers iupac name 1-pentyl-2-methyl-3-(1-naphthoyl)indole cas number155471-10-6 ypubchem cid10360860chemspider8536309unii5iq75333omcomptox dashboard (epa)dtxsid20165903 chemical and physical dataformulac25h25nomolar mass355.481 g·mol−13d model (jsmol)interactive image smiles c14ccccc4cccc1c(=o)c3c2ccccc2n(c3c)ccccc inchi inchi=1s/c25h25no/c1-3-4-9-17-26-18(2)24(22-14-7-8-16-23(22)26)25(27)21-15-10-12-19-11-5-6-13-20(19)21/h5-8,10-16h,3-4,9,17h2,1-2h3key:ibbnkinxtrkicj-uhfffaoysa-n (verify) another drug similarly named jhw-007 (not jwh) is a cocaine analog (the di-para-fluoro benztropine, being essentially a hybrid between benzatropine and difluoropine; with fluorine groups in the former or being descarbmethoxy in the latter) and atypical dopamine reuptake inhibitor, but is distinct from and not the same as this jwh-007. legal status in the united states, all cb1 receptor agonists of the 3-(1-naphthoyl)indole class such as jwh-007 are schedule i controlled substances. jwh-007 was banned in sweden on 1 october 2010 after being identified as an ingredient in "herbal" synthetic cannabis products. jwh-007 has been illegal in poland since august 2010 as of october 2015 jwh-007 is a controlled substance in china.