flufenamic acid flufenamic acid flufenamic acid (ffa) is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (nsaids).: 718 like other members of the class, it is a cyclooxygenase (cox) inhibitor, preventing the formation of prostaglandins. ffa is known to bind to and reduce the activity of prostaglandin f synthase and activate trpc6. flufenamic acidclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationby mouth, topicalatc codem01ag03 (who) legal statuslegal status au: s4 (prescription only) pharmacokinetic dataprotein bindingextensivelymetabolismhydroxylation, glucuronidationelimination half-life~3 hexcretion50% urine, 36% fecesidentifiers iupac name 2-benzoic acid cas number530-78-9 ypubchem cid3371iuphar/bps2447drugbankdb02266 ychemspider3254 yunii60gcx7y6bhkeggd01581 ychebichebi:42638 ychemblchembl23588 ycomptox dashboard (epa)dtxsid7023063 echa infocard100.007.723 chemical and physical dataformulac14h10f3no2molar mass281.234 g·mol−13d model (jsmol)interactive imagemelting point124 to 125 °c (255 to 257 °f) resolidification and remelting at 134°c to 136°csolubility in waterpractically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/ml (20 °c) smiles fc(f)(f)c1cc(ccc1)nc2ccccc2c(=o)o inchi inchi=1s/c14h10f3no2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18h,(h,19,20) ykey:lpepzbjokdyzad-uhfffaoysa-n y (verify) it is not widely used in humans as it has a high rate (30–60%) of gastrointestinal side effects.: 310 it is generally not available in the us. it is available in some asian and european countries as a generic drug. scientists led by claude winder from parke-davis invented ffa in 1963, along with fellow members of the class, mefenamic acid in 1961 and meclofenamic acid in 1964.: 718 although flufenamic acid was at one time informally referred to as "fluffy" (see history cache), this pet name could also refer to flufenoxine.