butizide butizide butizide (or thiabutazide) is a diuretic of the thiazide class. butizideclinical dataother namesthiabutazide, buthiazideatc codec03ea14 (who) (combination with potassium-sparing diuretics)pharmacokinetic databioavailability85%protein binding60–80%metabolismhepaticelimination half-life4 hoursexcretion30% unchanged with the urineidentifierscas number2043-38-1pubchem cid16274chemspider15442 yuniiw00ssd35vwkeggd03189comptox dashboard (epa)dtxsid6022713 echa infocard100.016.409 chemical and physical dataformulac11h16cln3o4s2molar mass353.84 g·mol−13d model (jsmol)interactive image smiles cc(c)cc1nc2=cc(=c(c=c2s(=o)(=o)n1)s(=o)(=o)n)cl inchi inchi=1s/c11h16cln3o4s2/c1-6(2)3-11-14-8-4-7(12)9(20(13,16)17)5-10(8)21(18,19)15-11/h4-6,11,14-15h,3h2,1-2h3,(h2,13,16,17) ykey:hgbfrhcdyzjrao-uhfffaoysa-n y medical uses butizide is used in combination with the potassium-sparing diuretic spironolactone for the second-line treatment of edema caused by heart failure, and for difficult cases of hypertension. adverse effects further information: thiazide § adverse effects interactions the hypotensive effects of butizide can be increased by antihypertensive drugs (especially ace inhibitors), barbiturates, tricyclic antidepressants, and ethanol. combinatino with beta blockers can increase blood glucose levels; and conversely, butizide can decrease the effects of antidiabetic drugs. as butizide lowers blood potassium and magnesium levels, it can increase the effects of cardiac glycosides. it can also increase lithium toxicity. nonsteroidal anti-inflammatory drugs can decrease the diuretic effect of butizide. pharmacology mechanism of action further information: thiazide § mechanism of action pharmacokinetics butizide is quickly absorbed from the gut with a bioavailability of 85%. it reaches highest blood plasma concentrations after 2.5 hours. plasma protein binding is 60 to 80%. while the substance is metabolised in the liver, 30% are excreted in unchanged from with the urine. elimination half-life is about four hours. chemistry synthesis thiabutazide synthesis