setastine setastine setastine (loderix) is an antihistamine used to treat allergies and rhinitis. setastineidentifiers iupac name 1-ethyl]azepane cas number64294-95-7hcl: 59767-13-4 ypubchem cid43082chemspider39258unii6g3ocf528jhcl: t2mb6p84on ychemical and physical dataformulac22h28clnomolar mass357.92 g·mol−13d model (jsmol)interactive image smiles cc(c1=cc=cc=c1)(c2=cc=c(c=c2)cl)occn3cccccc3 pharmacology pharmacodynamics setastine acts as a highly selective h1 receptor antagonist. it has no anticholinergic, antiadrenergic, or antiserotonergic effects. pharmacokinetics setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.