cepp cepp cepp is a chemotherapy regimen that is intended for treatment of aggressive non-hodgkin lymphomas. it consists of cyclophosphamide, etoposide, procarbazine, and prednisone. unlike chop, this chemotherapy regimen does not contain doxorubicin or any other anthracycline. thus, it can be used in patients with severe cardiovascular diseases and contraindications for doxorubicin-containing regimens. this regimen also does not contain vincristine and can be used in patients with neuropathy. there are several modifications of cepp. in combination with bleomycin, this regimen is called cepp (b). with the further addition of the anti-cd20 monoclonal antibody rituximab, it is called r-cepp(b). r-cepp(b) regimen consists of: rituximab - a monoclonal antibody that is able to kill cd20-positive b cells, either normal or malignant cyclophosphamide - an alkylating antineoplastic agent etoposide- a topoisomerase inhibitor from the epipodophyllotoxin group procarbazine - an alkylating antineoplastic agent prednisone or prednisolone - a glucocorticoid hormone that has the ability to cause apoptosis and lysis of lymphocytes, either normal or malignant bleomycin - an antitumor antibiotic r-cepp(b) dosing regimen drugdosemodedays rituximab375 mg/m2iv infusionday 1 cyclophosphamid600 mg/m2iv infusiondays 1 and 8 etoposide70 mg/m2iv infusiondays 1-3 procarbazine60 mg/m2po qddays 1-10 prednisone or prednisolone60 mg/m2po qddays 1-10 bleomycin10 iu/m2iv bolusday 1