betrixaban betrixaban betrixaban (trade name bevyxxa) is an oral anticoagulant drug which acts as a direct factor xa inhibitor. betrixaban is fda approved for venous thrombosis prevention in adults hospitalized for an acute illness who are at risk for thromboembolic complications. compared to other directly acting oral anticoagulants betrixaban has relatively low renal excretion and is not metabolized by cyp3a4. betrixabanclinical datatrade namesbevyxxaother namesprt054021, prt064445ahfs/drugs.combevyxxaroutes ofadministrationby mouthatc codeb01af04 (who) legal statuslegal status us: ℞-only pharmacokinetic dataprotein binding60%elimination half-life19–27 hrsduration of action≥72 hrsexcretion85% feces, 11% urineidentifiers iupac name n-(5-chloropyridin-2-yl)-2-(amino)-5-methoxybenzamide cas number330942-05-7 npubchem cid10275777drugbankdb12364 ychemspider18981107 yunii74rwp7w0j9keggd08873chebichebi:140421chemblchembl512351 ycomptox dashboard (epa)dtxsid10954727 echa infocard100.207.746 chemical and physical dataformulac23h22cln5o3molar mass451.905 g·mol−13d model (jsmol)interactive image smiles cn(c)c(=n)c1=cc=c(c=c1)c(=o)nc2=c(c=c(c=c2)oc)c(=o)nc3=nc=c(c=c3)cl inchi inchi=1s/c23h22cln5o3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25h,1-3h3,(h,27,30)(h,26,28,31) ykey:xholnrladusqld-uhfffaoysa-n y ny (what is this?) (verify) history betrixaban was originally developed by millennium pharmaceuticals. portola pharmaceuticals acquired rights for betrixaban in 2004 and co-developed it with merck. in 2011 merck discontinued joint development. the drug has undergone clinical trials for prevention of embolism after knee surgery and for prevention of stroke following non-valvular atrial fibrillation. betrixaban was also studied in a large phase iii clinical trial for extended duration thromboprophylaxis in acute ill patients. previously apixaban and rivaroxaban have failed to show positive risk/benefit ratio in this indication compared to enoxaparin. apex trial compared betrixaban with enoxaparin and included 7513 patients. lower rate of vte events was found in betrixaban arm with no increase in major bleedings compared to enoxaparin. based on these results betrixaban was approved by fda on june 23, 2017, becoming the first doac approved for extended prophylaxis in hospitalized patients. betrixaban has been also reviewed by ema but didn't receive marketing approval in eu mainly due to concerns of increased bleeding risk and absence of reversal agent.