golexanolone golexanolone golexanolone, also known by the developmental code name gr-3027, is a neurosteroid medication which is under development for the treatment of hypersomnia and hepatic encephalopathy. it acts as a negative allosteric modulator of the gabaa receptor. the medication selectively antagonizes the stimulatory actions of inhibitory neurosteroids like allopregnanolone and tetrahydrodeoxycorticosterone (thdoc) at the gabaa receptor, while not affecting the activation of the gabaa receptor by γ-aminobutyric acid (gaba). golexanoloneclinical dataother namesgr-3027; 3α-ethynyl-3β-hydroxyandrostan-17e-one oximeidentifiers iupac name (3s,5s,8r,9s,10s,13s,14s,17e)-3-ethynyl-17-hydroxyimino-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1h-cyclopentaphenanthren-3-ol cas number2089238-18-4pubchem cid132190533chemspider76826990unii9c48f08tp2chemical and physical dataformulac21h31no2molar mass329.484 g·mol−13d model (jsmol)interactive image smiles c12cc(c1cc32cc\4(3cc/c4=n\o)c)(c#c)o inchi inchi=1s/c21h31no2/c1-4-21(23)12-11-19(2)14(13-21)5-6-15-16-7-8-18(22-24)20(16,3)10-9-17(15)19/h1,14-17,23-24h,5-13h2,2-3h3/b22-18+/t14-,15-,16-,17-,19-,20-,21-/m0/s1key:ffibgvytwnplpn-bzlgyyabsa-n