for ecstasy (a book examining the uses of the street drug ecstasy in the uk) the writer, activist and ecstasy advocate nicholas saunders highlighted test results showing that certain consignments of the drug also contained selegiline. consignments of ecstasy known as "strawberry" contained what saunders described as a "potentially dangerous combination of ketamine, ephedrine and selegiline," as did a consignment of "sitting duck" ecstasy tablets. david pearce wrote the hedonistic imperative six weeks after starting taking selegiline. in gregg hurwitz's novel out of the dark, selegiline (emsam) and tyramine-containing food were used to assassinate the president of the united states. veterinary use in veterinary medicine, selegiline is sold under the brand name anipryl (manufactured by zoetis). it is used in dogs to treat canine cognitive dysfunction and, at higher doses, pituitary-dependent hyperadrenocorticism (pdh). canine cognitive dysfunction is a form of dementia that mimics alzheimer's disease in humans. geriatric dogs treated with selegiline show improvements in sleeping pattern, reduced incontinence, and increased activity level; most show improvements by one month. though it is labeled for dog use only, selegiline has been used off-label for geriatric cats with cognitive dysfunction. selegiline's efficacy in treating pituitary-dependent hyperadrenocorticism has been disputed. theoretically, it works by increasing dopamine levels, which downregulates the release of acth, eventually leading to reduced levels of cortisol. some claim that selegiline is only effective at treating pdh caused by lesions in the anterior pituitary (which comprise most canine cases). the greatest sign of improvement is lessening of abdominal distention. side effects in dogs are uncommon, but they include vomiting, diarrhea, diminished hearing, salivation, decreased weight and behavioral changes such as hyperactivity, listlessness, disorientation, and repetitive motions. selegiline does not appear to have a clinical effect on horses. research selegiline has been limitedly studied in the treatment of attention deficit hyperactivity disorder (adhd) in both children/adolescents and adults. in a small randomized trial of selegiline for treatment of adhd in children, there were improvements in attention, hyperactivity, and learning/memory performance but not in impulsivity. in another small randomized controlled trial of selegiline for the treatment of adult adhd, a high dose of the medication for 6 weeks was not significantly more effective than placebo in improving symptoms.