dat (chemotherapy) dat (chemotherapy) dat in the context of chemotherapy is an acronym that means a chemotherapy regimen most often used as an induction regimen in acute myelogenous leukemia, usually for those who are refractory to the standard "7+3" induction regimen or who has relapsed. but this regimen also can be used as primary, first-line induction therapy. datspecialtyoncology the dat regimen consists of: (d)aunorubicin - an anthracycline antibiotic that is able to intercalate dna, thus disrupting cell division and preventing mitosis; (a)ra-c (cytarabine) - an antimetabolite; (t)hioguanine - another antimetabolite. dosing regimen drugdosemodedays ara-c (cytarabine)200 mg/m2iv push every 12 hours in 2 divided doses (100 mg/m2 each)days 1-10 daunorubicin50 mg/m2iv slow pushdays 1, 3 and 5 thioguanine200 mg/m2po every 12 hours in 2 divided doses (100 mg/m2 each)days 1-10