piperidylthiambutene piperidylthiambutene piperidylthiambutene (piperidinohton) is a synthetic opioid analgesic drug from the thiambutene family, which has around the same potency as morphine. piperidylthiambutene is structurally distinct from fentanyl, its analogues, and other synthetic opioids previously reported. if sold or obtained for the purpose of human consumption it could be considered a controlled substance analogue in some countries such as the us, australia and new zealand. piperidylthiambutene has been sold as a designer drug, first appearing in late 2018. piperidylthiambuteneclinical dataatc codenoneidentifiers iupac name 1-piperidine cas number54160-31-5 ypubchem cid3041503chemspider2304772unii4bu0bcp2e1chemical and physical dataformulac17h21ns2molar mass303.48 g·mol−13d model (jsmol)interactive imagemelting point188 to 189 °c (370 to 372 °f) smiles c1ccccn1c(c)c=c(c3cccs3)c2sccc2 inchi inchi=1s/c17h21ns2/c1-14(18-9-3-2-4-10-18)13-15(16-7-5-11-19-16)17-8-6-12-20-17/h5-8,11-14h,2-4,9-10h2,1h3key:fqrwjlvmjcksme-uhfffaoysa-n (verify) synthesis patent: the grignard reaction between 3-piperidinobutyric acid ethyl ester, cid:10774378 (1) and 2-bromothiophene (2) gives 3. dehydration in acid completes the synthesis.