and neuroglia of the brain, and their cavities are modified to form its ventricles. the remainder of the tube forms the spinal cord (medulla spinalis); from its ectodermal wall the nervous and neuroglial elements of the spinal cord are developed, while the cavity persists as the central canal. formation of the early septum the extension of the mesoderm takes place throughout the whole of the embryonic and extra-embryonic areas of the ovum, except in certain regions. one of these is seen immediately in front of the neural tube. here the mesoderm extends forward in the form of two crescentic masses, which meet in the middle line so as to enclose behind them an area that is devoid of mesoderm. over this area, the ectoderm and endoderm come into direct contact with each other and constitute a thin membrane, the buccopharyngeal membrane, which forms a septum between the primitive mouth and pharynx. early formation of the heart and other primitive structures in front of the buccopharyngeal area, where the lateral crescents of mesoderm fuse in the middle line, the pericardium is afterward developed, and this region is therefore designated the pericardial area. a second region where the mesoderm is absent, at least for a time, is that immediately in front of the pericardial area. this is termed the proamniotic area, and is the region where the proamnion is developed; in humans, however, it appears that a proamnion is never formed. a third region is at the hind end of the embryo, where the ectoderm and endoderm come into apposition and form the cloacal membrane. somitogenesis main article: somitogenesis somitogenesis is the process by which somites (primitive segments) are produced. these segmented tissue blocks differentiate into skeletal muscle, vertebrae, and dermis of all vertebrates. somitogenesis begins with the formation of somitomeres (whorls of concentric mesoderm) marking the future somites in the presomitic mesoderm (unsegmented paraxial). the presomitic mesoderm gives rise to successive pairs of somites, identical in appearance that differentiate into the same cell types but the structures formed by the cells vary depending upon the anteroposterior (e.g., the thoracic vertebrae have ribs, the lumbar vertebrae do not). somites have unique positional values along this axis and it is thought that these are specified by the hox homeotic genes. toward the end of the second week after fertilization, transverse segmentation of the paraxial mesoderm begins, and it is converted into a series of well-defined, more or less cubical masses, also known as the somites, which occupy the entire length of the trunk on either side of the middle line from the occipital region of the head. each segment contains a central cavity (known as a organogenesis main article: organogenesis human embryo, 8-9 weeks, 38 mm (1.5 in) at some point after the different germ layers are defined, organogenesis begins. the first stage in vertebrates is called neurulation, where the neural plate folds forming the neural tube (see above). other common organs or structures that arise at this time include the heart and somites (also above), but from now on embryogenesis follows no common pattern among the different taxa of the animalia. in most animals organogenesis, along with morphogenesis, results in a larva. the hatching of the larva, which must then undergo metamorphosis, marks the end of embryonic development.