hydrazine (antidepressant) hydrazine (antidepressant) the hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (maois) which were discovered and initially marketed in the 1950s and 1960s. most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use. this article is about a series of antidepressants. for the toxic, unstable compound with the chemical formula n2h4, see hydrazine. iproniazid, the first hydrazine maoi to be discovered. tranylcypromine, a structurally unrelated maoi introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity. list of hydrazine antidepressants marketed benmoxin (neuralex, nerusil) ‡ iproclozide (sursum) ‡ iproniazid (marsilid) ‡ isocarboxazid (marplan) mebanazine (actomol) ‡ nialamide (niamid) ‡ octamoxin (ximaol, nimaol) ‡ phenelzine (nardil) pheniprazine (catron) ‡ phenoxypropazine (drazine) ‡ pivhydrazine (tersavid) ‡ safrazine (safra) ‡ legend: ‡ = withdrawn from the market; † = partially discontinued; bolded names indicate major drugs. never marketed carbenzide cimemoxin domoxin metfendrazine parkinson's carbidopa tranquillosedative centazolone