floctafenine floctafenine floctafenine is a nonsteroidal anti-inflammatory drug (nsaid). floctafenineclinical dataahfs/drugs.cominternational drug namesatc coden02bg04 (who) identifiers iupac name 2,3-dihydroxypropyl 2-benzoate cas number23779-99-9pubchem cid3360drugbankdb08976 nchemspider3243uniio04hvx6a9qcomptox dashboard (epa)dtxsid8057695 echa infocard100.041.696 chemical and physical dataformulac20h17f3n2o4molar mass406.361 g·mol−13d model (jsmol)interactive image smiles fc(f)(f)c1cccc2c(ccnc12)nc3ccccc3c(=o)occ(o)co inchi inchi=1s/c20h17f3n2o4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27h,10-11h2,(h,24,25)key:apqpgqgawabjln-uhfffaoysa-n synthesis flocatfenine synthesis:u.s. patent 3,644,368 roussel uclaf; the scheme involves first the conversion of ortho-trifluoromethyl aniline (1) to a quinolol. the compound is thus condensed with emme (ethoxy methylene malonic diethyl ester) and cyclized thermally (2). that intermediate is then saponified; the resulting acid is decarboxylated and finally converted to the 4-chloroquinoline (3) by reaction with phosphorus oxychloride. the displacement of chlorine with methyl anthranilate (4) then affords the coupled intermediate (5). an ester interchange of that product with glycerol leads to the glyceryl ester. there is thus obtained the nsaid floctafenine.