schöpf–schulz–passarge syndrome schöpf–schulz–passarge syndrome schöpf–schulz–passarge syndrome is an autosomal recessive condition with punctate symmetric palmoplantar keratoderma, with the keratoderma and fragility of the nails beginning around age 12.: 513 in addition to palmoplantar keratoderma, other symptoms include hypodontia, hypotrichosis, nail dystrophies, and eyelid cysts (apocrine hidrocystomas). patients may also develop syringofibroadenoma and squamous cell carcinomas. schöpf–schulz–passarge syndromeother nameseyelid cysts, palmoplantar keratoderma, hypodontia, and hypotrichosisspecialtymedical genetics it was characterized in 1971. it has been associated with wnt10a.