5f-mdmb-pica 5f-mdmb-pica 5f-mdmb-pica is a designer drug and synthetic cannabinoid. in 2018, it was the fifth-most common synthetic cannabinoid identified in drugs seized by the drug enforcement administration. 5f-mdmb-picaclinical dataother names5f-mdmb-2201; 5-fluoro mdmb-picalegal statuslegal status ca: schedule ii de: anlage ii (authorized trade only, not prescriptible) uk: class b us: schedule i un: psychotropic schedule ii identifiers iupac name methyl (2s)-2-amino]-3,3-dimethylbutanoate cas number1971007-88-1pubchem cid129597835chemspider68003951uniing3u6o970achemical and physical dataformulac21h29fn2o3molar mass376.472 g·mol−13d model (jsmol)interactive image smiles o=c(n(c(oc)=o)c(c)(c)c)c1=cn(cccccf)c2=c1c=cc=c2 inchi inchi=1s/c21h29fn2o3/c1-21(2,3)18(20(26)27-4)23-19(25)16-14-24(13-9-5-8-12-22)17-11-7-6-10-15(16)17/h6-7,10-11,14,18h,5,8-9,12-13h2,1-4h3,(h,23,25)/t18-/m1/s1key:chsueebesacqdv-gosisdbhsa-n 5f-mdmb-pica is a potent agonist of both the cb1 receptor and the cb2 receptor with ec50 values of 0.45 nm and 7.4 nm, respectively. in the united states, 5f-mdmb-pica was temporarily emergency scheduled by the dea in 2019. in december 2019, the unodc announced scheduling recommendations placing 5f-mdmb-pica into schedule ii. in the united states 5f-mdmb-pica was made a permanent schedule i controlled substance nationwide on april 7, 2022.