rq-00203078 rq-00203078 rq-00203078 is a drug which acts as a potent and selective blocker of the trpm8 ion channel, which is the main receptor responsible for the sensation of cold. it was developed as a potential analgesic, and blocks the development of hyperalgesia following exposure to cold temperatures or chronic morphine administration. rq-00203078identifiers iupac name 4-(-sulfamoyl)benzoic acid cas number1254205-52-1pubchem cid49783953chemspider34979854chemblchembl3353597chemical and physical dataformulac21h13clf6n2o5smolar mass554.84 g·mol−13d model (jsmol)interactive image smiles c1=cc(=cc=c1cn(c2=c(c=c(c=n2)c(f)(f)f)cl)s(=o)(=o)c3=cc=c(c=c3)c(=o)o)oc(f)(f)f inchi inchi=1s/c21h13clf6n2o5s/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10h,11h2,(h,31,32)key:ijgqfzyyehcciz-uhfffaoysa-n