thioperamide thioperamide thioperamide is a potent hrh4 antagonist and selective hrh3 antagonist capable of crossing the blood–brain barrier. it was used by jean-charles schwartz in his early experiments regarding the h3 receptor. thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine, and enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine. thioperamideclinical dataatc codenoneidentifiers iupac name n-cyclohexyl-4-(1h-imidazol-4-yl)piperidine-1-carbothioamide cas number106243-16-7 npubchem cid3035905iuphar/bps1267chemspider2300031 yuniiii4319bwuichemblchembl260374 ycomptox dashboard (epa)dtxsid50147555 chemical and physical dataformulac15h24n4smolar mass292.45 g·mol−13d model (jsmol)interactive image smiles s=c(nc1ccccc1)n3ccc(c2cnc2)cc3 inchi inchi=1s/c15h24n4s/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13h,1-9h2,(h,16,17)(h,18,20) ykey:qkddjdbfonzgbw-uhfffaoysa-n y ny (what is this?) (verify) its action on h3 is thought to promote wakefulness and improve memory consolidation.