eltoprazine eltoprazine eltoprazine (developmental code name du-28,853) is a serotonergic drug of the phenylpiperazine class which is described as a serenic or antiaggressive agent. it acts as an agonist of the serotonin 5-ht1a and 5-ht1b receptors and as an antagonist of the serotonin 5-ht2c receptor. the drug is closely related to fluprazine and batoprazine, which are similarly acting agents, and is also a known chemical precursor to s-15535 and lecozotan. eltoprazine is or was under development for the treatment of aggression, attention deficit hyperactivity disorder (adhd), cognition disorders, and drug-induced dyskinesia, but no recent development has been reported for these indications as of february 2022. it was also under development for the treatment of psychotic disorders, but development for this indication was discontinued. eltoprazine was originated by solvay and was developed by elto pharma, psychogenics, and solvay. eltoprazineclinical dataother namesdu-28,853; du-28853identifiers iupac name 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine cas number98224-03-4pubchem cid65853chemspider59265unii510m006ko6chemblchembl282614comptox dashboard (epa)dtxsid5048425 chemical and physical dataformulac12h16n2o2molar mass220.272 g·mol−13d model (jsmol)interactive image smiles c1cn(ccn1)c2=c3c(=cc=c2)occo3 inchi inchi=1s/c12h16n2o2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13h,4-9h2key:wvlhgcrwehciot-uhfffaoysa-n