jwh-398 jwh-398 jwh-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the cb1 and cb2 receptors. it has mild selectivity for cb1 with a ki of 2.3 nm and 2.8 nm at cb2. this synthetic chemical compound was identified by the emcdda as an ingredient in three separate "herbal incense" products purchased from online shops between february and june 2009. it was discovered by, and named after, john w. huffman. jwh-398legal statuslegal status ca: schedule ii de: npsg (industrial and scientific use only) uk: class b us: schedule i illegal in latvia identifiers iupac name 1-pentyl-3-(4-chloro-1-naphthoyl)indole cas number1292765-18-4 nchemspider28647395 nuniirx0e95s90hcomptox dashboard (epa)dtxsid40156131 chemical and physical dataformulac24h22clnomolar mass375.90 g·mol−13d model (jsmol)interactive image smiles c14ccccc1n(ccccc)cc4c(=o)c(cc3)c2ccccc2c3cl inchi inchi=1s/c24h22clno/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16h,2-3,8,15h2,1h3 nkey:iuwbhgfohxvvkv-uhfffaoysa-n n ny (what is this?) (verify) in the united states, jwh-398 is a schedule i controlled substance.