congenital syphilis. airway/kidney involvementgranulomatosis with polyangiitis, bronchial asthma. nose cartilage involvement/saddle nosegranulomatosis with polyangiitis, leishmaniasis, congenital syphilis, leprosy, aspergillosis, paracoccidioidomycosis, cocaine inhalation, systemic lupus erythematosus. subglottic stenosisprior endotracheal intubation, amyloidosis, sarcoidosis. vascular involvementtakayasu's arteritis, polyarteritis nodosa, behçet's disease, antiphospholipid syndrome. vestibular diseaseposterior circulation infarct, vestibulitis, benign paroxysmal vertigo, ménière's disease. treatment there are no prospective randomized controlled trials studying therapies for relapsing polychondritis. evidence for efficacy of treatments is based on many case reports and series of small groups of patients. there are case reports that non-steroidal anti-inflammatories are effective for mild disease and that corticosteroids are effective for treatment of severe relapsing polychondritis. there are multiple case reports that dapsone is effective in doses from 25 mg/day to 200 mg/day. corticosteroid-sparing medications such as azathioprine or methotrexate may be used to minimize steroid doses and limit the side effects of steroids. for severe disease cyclophosphamide is often given in addition to high dose intravenous steroids. prognosis many individuals have mild symptoms, which recur infrequently, while others may have persistent problems that become debilitating or life-threatening. epidemiology relapsing polychondritis occurs as often in men as in women. in a mayo clinic series, the annual incidence was about 3.5 cases per million. the highest incidence is between the ages of 40 and 50 years, but it may occur at any age. history in 1923, rudolf jaksch von wartenhorst first discovered relapsing polychondritis while working in prague and initially named it polychondropathia. the discoverer of relapsing polychondritis rudolf jaksch von wartenhorst. his patient was a 32-year-old male brewer who presented with fever, asymmetric polyarthritis, and the ears and nose showed signs of swelling, deformity and were painful. biopsy of nasal cartilage revealed loss of the cartilage matrix and a hyperplastic mucous membrane. jaksch von wartenhorst considered this was an undescribed degenerative disorder of cartilage and named it polychondropathia. he even took his patient's occupation into consideration, and related the cause to excessive alcohol intake. since then, the disease has received many names. the following table shows the history of the nomenclature of relapsing polychondritis. the current name, relapsing polychondritis (rp), was introduced by pearson and his colleagues in 1960 to emphasize the episodic course of the disease. suggested nameauthor(s) and year polychondropathiarudolf jaksch von wartenhorst in 1923 chondromalaciavon meyenburg in 1936 and altherr in 1936 panchondritisharders in 1954 polychondritis chronica atrophicansbober and czarniecki in 1955 chronic atrophic polychondritisbean, drevets, and chapman in 1958 relapsing polychondritispearson, kline, and newcomer in 1960 atrophic polychondritisrhys davies and kelsall in 1961 research there has been little research on neurological problems related to rp. if these cartilage structures get inflamed, they could press against nerves and cause a variety of problems that is seen in rp like peripheral neuropathy and many more.