detected in children and adults, they indicate an increased demand for red blood cells, which can be caused by bleeding, some cancers and anemia. most analyzers can detect these cells as part of the differential cell count. high numbers of nucleated red cells can cause a falsely high white cell count, which will require adjusting. other parameters advanced hematology analyzers generate novel measurements of blood cells which have shown diagnostic significance in research studies but have not yet found widespread clinical use. for example, some types of analyzers produce coordinate readings indicating the size and position of each white blood cell cluster. these parameters (termed cell population data) have been studied as potential markers for blood disorders, bacterial infections and malaria. analyzers that use myeloperoxidase staining to produce differential counts can measure white blood cells' expression of the enzyme, which is altered in various disorders. some instruments can report the percentage of red blood cells that are hypochromic in addition to reporting the average mchc value, or provide a count of fragmented red cells (schistocytes), which occur in some types of hemolytic anemia. because these parameters are often specific to particular brands of analyzers, it is difficult for laboratories to interpret and compare results. reference ranges