blister beetle dermatitis blister beetle dermatitis blister beetle dermatitis is a cutaneous condition that occurs after contact with any of several types of beetles, including those from the meloidae and oedemeridae families.: 449 blister beetles secrete an irritant called cantharidin, a vesicant that can get onto humans if they touch the beetles. blister beetle dermatitisspecialtydermatology the term "blister beetle dermatitis" is also occasionally and inappropriately used as a synonym for paederus dermatitis, a somewhat different dermatitis caused by contact with pederin, an irritant in the hemolymph of a different group of beetles, the rove beetles. symptoms and signs after skin comes in contact with cantharidin, local irritation begins within a few hours. (this is in contrast to paederus dermatitis, where symptoms first appear 12–36 hours after contact with rove beetles.) painful blisters appear, but scarring from these epidermal lesions is rare. diagnosis typical vesicles/blister at site where beetle salivates. treatment wash with soap and water. cold application topical steroid and antihistamines application.