bamforth–lazarus syndrome bamforth–lazarus syndrome bamforth–lazarus syndrome is a genetic condition that results in thyroid dysgenesis. it is due to recessive mutations in forkhead/winged-helix domain transcription factor (fklh15 or ttf2). it is associated with foxe1. bamforth–lazarus syndromeother namesathyroidal hypothyroidism-spiky hair-cleft palate syndrome