ht-2157 ht-2157 ht-2157 (former development code snap-37889) is a drug which acts as a selective non-peptide antagonist for the receptor gal-3, which is usually activated by the neuropeptide galanin. blocking this receptor with ht-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. all human clinical trials were terminated due to safety concerns however, and new gal-3 antagonists are now being sought instead. ht-2157clinical dataatc codenoneidentifiers iupac name 1-phenyl-3-iminoindol-2-one cas number303149-14-6pubchem cid1471834iuphar/bps6126chemspider1213983uniij4drj9bfs1chemical and physical dataformulac21h13f3n2omolar mass366.343 g·mol−13d model (jsmol)interactive image smiles c14ccccc4n(-c3ccccc3)c(=o)c1=n\c(c2)cccc2c(f)(f)f inchi inchi=1s/c21h13f3n2o/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13h/b25-19+key:txcgmrvpxubhal-nceldcmtsa-n