mitrofanoff principle mitrofanoff principle in urology, the mitrofanoff principle is the creation of a passageway for urine or enema fluid that, by its (surgical) construction, has a valve mechanism to allow continence. procedures which make use of the mitrofanoff principle: mitrofanoff procedure malone antegrade continence enema monti procedure eponym it is named after the french urologist (mitrofanoff) who popularized it.