acrylfentanyl acrylfentanyl acrylfentanyl (also known as acryloylfentanyl or egyptenyl) is a highly potent opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug. in animal studies the ic50 or half maximal inhibitory concentration for acrylfentanyl to displace naloxone is 1.4 nm, being slightly more potent than fentanyl itself (1.6 nm) as well as having a longer duration of action. acrylfentanylclinical dataatc codenonelegal statuslegal status ca: schedule i de: anlage ii (authorized trade only, not prescriptible) uk: class a us: schedule i illegal in sweden identifiers iupac name n-phenyl-n-prop-2-enamide cas number82003-75-6hcl: 79279-03-1pubchem cid10314851hcl: 12782338chemspider8490316hcl: 24621155uniit64k7yd33bhcl: qy70u25h9mchemblchembl1196205hcl: chembl556159chemical and physical dataformulac22h26n2omolar mass334.463 g·mol−13d model (jsmol)interactive imagehcl: interactive image smiles c=cc(=o)n(c2ccccc2)c1ccn(cc1)ccc3ccccc3hcl: c=cc(=o)n(c2ccccc2)c1ccn(cc1)ccc3ccccc3.cl inchi inchi=1s/c22h26n2o/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h2-12,21h,1,13-18h2key:rfqnlmwuijjeqf-uhfffaoysa-nhcl: inchi=1s/c22h26n2o.clh/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19;/h2-12,21h,1,13-18h2;1hkey:yuhnrliklnypdd-uhfffaoysa-n side effects side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. fentanyl analogs have killed hundreds of people throughout europe and the former soviet republics since the most recent resurgence in use began in estonia in the early 2000s, and novel derivatives continue to appear. as acrylamide derivatives are often used in drug discovery to make covalent inhibitors which will bind irreversibly to its target, acrylfentanyl is claimed to be naloxone resistant. however, acute intoxications with acrylfentanyl on mice threatened by naloxone (2 mg/kg) have shown that acrylfentanyl could be displaced from the opioid receptor. acrylfentanyl has been linked to 20 deaths in sweden as well as two deaths in denmark in summer 2016. legal status acrylfentanyl is a schedule i controlled substance in the united states. as of 16 august 2016, it is an illegal medicine in sweden.