mediators and cytotoxic cell products, and improves lung function in animal modelscontrolled clinical trials allergic encephalomyelitiseffective in animal models– allergic rhinitiseffects as for adult respiratory distress syndrome, although no specific nasal model has been testedcontrolled clinical trial arthritisinhibits cell accumulation, collagen destruction and angiogenesisanecdotal report asthmaas for adult respiratory distress syndrome, however, it has also been shown to improve lung function in experimental modelscontrolled clinical trials cancerinhibits tumour growth, metastasis and angiogenesis, and increases survival time in animal modelsseveral anecdotal reports delayed-type hypersensitivity reactionseffective in animal models– inflammatory bowel diseaseinhibits inflammatory cell transport in general, no specific model testedcontrolled clinical trials interstitial cystitiseffective in a human experimental model of interstitial cystitisrelated molecule now used clinically transplant rejectionprolongs allograft survival in animal models– – indicates that no information is available as a result of heparin's effect on such a wide variety of disease states, a number of drugs are indeed in development whose molecular structures are identical or similar to those found within parts of the polymeric heparin chain. drug moleculeeffect of new drug compared to heparinbiological activities heparin tetrasaccharidenonanticoagulant, nonimmunogenic, orally activeantiallergic pentosan polysulfateplant derived, little anticoagulant activity, anti-inflammatory, orally activeanti-inflammatory, antiadhesive, antimetastatic phosphomannopentanose sulfatepotent inhibitor of heparanase activityantimetastatic, antiangiogenic, anti-inflammatory selectively chemically o-desulphated heparinlacks anticoagulant activityanti-inflammatory, antiallergic, antiadhesive