list of investigational obsessive–compulsive disorder drugs list of investigational obsessive–compulsive disorder drugs this is a list of investigational obsessive–compulsive disorder drugs, or drugs that are currently under development for clinical use in the treatment of obsessive–compulsive disorder (ocd) but are not yet approved. chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. under development actively under development immunoglobulin (immune globulin 10%, 10% high purity immunoglobulin, 10% ivig, newgam, newnorm, octagam 10%, octagam, panzyga) – immunoglobulin / immunostimulant troriluzole (bhv-4157, bhv-4157a, fc-4157; trigriluzole) – prodrug of riluzole / glutamate modulator preclinical development cannabis extracts (various) – cannabinoid receptor modulators no development reported 4'-fluorocannabidiol (4'-f-cbd; fluorinated cannabidiol; huf-101, huf-102, huf-103) – cannabinoid receptor modulator, other actions abbvie/rugen research programme – unspecified mechanism of action agomelatine (alodil, melitor, thymanax, valdoxan, vestin; ago-178, ago178c, s-20098, s-20098-f55) – serotonin 5-ht2c receptor antagonist and melatonin receptor agonist cr-5542 – orexin receptor antagonist dual ssris and serotonin 5-ht1a receptor agonists (ssa-426, way-163426, way-211612, way-253752, way-426) risperidone (risperdal, risperdal consta, risperdal depot; jnj-410397-aaa, r-64766, r064766) – atypical antipsychotic / monoamine receptor modulator secretin (secreflo; inn-329, rg-1068) – hormone/diagnostic agent sosei heptares research programme – various mechanisms of action not under development development discontinued bitopertin (r-1678, rg-6718, rg1678, ro-4917838) – glycine glyt1 inhibitors / glycine reuptake inhibitor cycloserine (d-cycloserine; tik-101) – glutamate nmda receptor partial agonist elzasonan (cp-448187, cp-448187-01) – serotonin 5-ht1b and 5-ht1d receptor antagonist f-14258 – serotonin 5-ht1b and 5-ht1d receptor antagonist fluoxetine/naltrexone (orex-004) – selective serotonin reuptake inhibitor and opioid receptor antagonist mavoglurant (afq-056) – glutamate mglu5 receptor antagonist npl-2003 – glutamate modulator ondansetron (setrodon; to-2061) – serotonin 5-ht3 receptor antagonist ro-600175 – serotonin 5-ht2c receptor agonist roxindole (emd-49980) – dopamine receptor agonist, serotonin receptor modulator, adrenergic receptor modulator, and serotonin reuptake inhibitor sb-200646 (sb-200646a) – serotonin 5-ht2b and 5-ht2c receptor antagonist formal development never or not yet started 5-ht6 receptor agonists (e.g., way-181187, way-208466) antiandrogens (e.g., flutamide, cyproterone acetate, triptorelin) cannabinoids (e.g., nabilone, tetrahydrocannabinol (thc)/cannabis) – cannabinoid receptor modulators nmda receptor modulators (e.g., ketamine, memantine, nitrous oxide, rapastinel) nonsteroidal anti-inflammatory drugs (nsaids) (e.g., celecoxib, naproxen) – cyclooxygenase inhibitors rituximab (rituxan) – monoclonal antibody against cd20 serotonergic psychedelics (e.g., psilocybin/psilocybin mushrooms, lysergic acid diethylamide (lsd)) – serotonin receptor modulators tolcapone (tasmar) – catechol-o-methyltransferase inhibitor clinically used drugs approved drugs clomipramine (anafranil) – tricyclic antidepressant / monoamine reuptake inhibitor and receptor modulator escitalopram (s-citalopram; cipralex, entact, lexapro, seroplex, sipralex, sipralexa; lu-26054; mld-55) – selective serotonin reuptake inhibitor fluoxetine (prozac, prozac weekly, reneuron, sarafem; ly-110140) – selective serotonin reuptake inhibitor fluvoxamine (depromel, luvox, luvox cr; sme-3110) – selective serotonin reuptake inhibitor and sigma-1 receptor agonist paroxetine (aropax, deroxat, divarius, dropax, dropaxin, frosinor, motivan, paxil, paxil cr, serestill, seroxat, tagonis; brl-29060, brl-29060a, fg-7051, nnc-207051, si-211103) – selective serotonin reuptake inhibitor sertraline (aremis, besitran, gladem, j zoloft, lustral, serad, serlain, tatig, zoloft; cp-51974, cp-51974-01) – selective serotonin reuptake inhibitor off-label drugs atypical antipsychotics (e.g., aripiprazole, olanzapine, quetiapine, risperidone) – monoamine receptor modulators