gamma-melanocyte-stimulating hormone gamma-melanocyte-stimulating hormone γ-melanocyte-stimulating hormone (γ-msh) is an endogenous peptide hormone and neuropeptide. it is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (msh), and is produced from proopiomelanocortin (pomc). it is an agonist of the mc1, mc3, mc4, and mc5 receptors. it exists in three forms, γ1-msh, γ2-msh, and γ3-msh. γ-melanocyte-stimulating hormone names iupac name l-tyrosyl-l-valyl-l-methionylglycyl-l-histidyl-l-phenylalanyl-l-arginyl-l-tryptophyl-l-α-aspartyl-l-arginyl-l-phenylalaninamide other names gamma-msh, γ-melanotropin, γ-melanocortin, γ-intermedin identifiers cas number 72629-65-3 3d model (jsmol) interactive image pubchem cid 16146269 comptox dashboard (epa) dtxsid30657546 smiles cc(c)(c(=o)n(ccsc)c(=o)ncc(=o)n(cc1=cnc=n1)c(=o)n(cc2=cc=cc=c2)c(=o)n(cccnc(=n)n)c(=o)n(cc3=cnc4=cc=cc=c43)c(=o)n(cc(=o)o)c(=o)n(cccnc(=n)n)c(=o)n(cc5=cc=cc=c5)c(=o)ncc(=o)o)nc(=o)(cc6=cc=c(c=c6)o)n properties chemical formula c74h99n21o16s molar mass 1570.80 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references γ-msh regulated cardiovascular functions. γ-msh effects are measured through the effects it has on the central neural pathway dispersed throughout the kidney. it is not moderated based on tubular sodium transport. gamma-msh activates mc3r in renal tubular cells by limiting sodium absorption by inhibiting the central neural pathway. this regulates sodium balance and blood pressure. if mc3r is absent then there is resistance in γ-msh which results in hypertension on hsd.