inflammatory fibroid polyp inflammatory fibroid polyp inflammatory fibroid polyp (ifp) is a benign abnormal growth of tissue projecting into the lumen of the gastrointestinal tract. inflammatory fibroid polypmicrograph of an inflammatory fibroid polyp. h&e stain. pathology ifps consist of spindle cells that are concentrically arranged around blood vessels and have inflammation, especially eosinophils. they may have leiomyoma/schwannoma-like areas with nuclear palisading. they typically stain with cd34 and vimentin, and, generally, do not stain with cd117 and s100. the endoscopic differential diagnosis includes other benign, pre-malignant and malignant gastrointestinal polyps. high mag. morphological differential diagnosis inflammatory myofibroblastic tumour (imt)