am-4030 am-4030 am-4030 is an analgesic drug which is a cannabinoid receptor agonist. it is a derivative of hu-210 which has been substituted with a 6β-((e)-3-hydroxyprop-1-enyl) group. this adds a "southern" aliphatic hydroxyl group to the molecule as seen in the cp-series of nonclassical cannabinoid drugs, and so am-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry. this gives am-4030 a greater degree of selectivity, so while it is still a potent agonist at both cb1 and cb2, it is reasonably selective for cb1, with a ki of 0.7nm at cb1 and 8.6nm at cb2, a selectivity of around 12x. resolution of the enantiomers of am-4030 yields an even more potent compound, although with less selectivity, with the (-) enantiomer am-4030a having a ki of 0.6nm at cb1 and 1.1nm at cb2. am-4030identifiers iupac name (6s,6ar,9r,10ar)-9-(hydroxymethyl)-6--6-methyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydrobenzochromen-1-ol cas number587023-54-9 ypubchem cid10550598chemspider8725989 yuniicgygfrrxkkchemical and physical dataformulac27h42o4molar mass430.629 g·mol−13d model (jsmol)interactive image smiles occ=cc3(c)c1ccc(co)cc1c2c(o3)cc(cc2o)c(c)(c)cccccc inchi inchi=1s/c27h42o4/c1-5-6-7-8-12-26(2,3)20-16-23(30)25-21-15-19(18-29)10-11-22(21)27(4,13-9-14-28)31-24(25)17-20/h9,13,16-17,19,21-22,28-30h,5-8,10-12,14-15,18h2,1-4h3/b13-9+/t19-,21-,22-,27+/m1/s1 ykey:sykowcskdyzbil-bktwvjdesa-n y (verify)