endemic (epidemiology) endemic (epidemiology) in epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly present, or maintained at a baseline level, without extra infections being brought into the group as a result of travel or similar means. an endemic disease always has a steady, predictable number of people getting sick, but that number can be high (hyperendemic) or low (hypoendemic), and the disease can be severe or mild. also, a disease that is usually endemic can become epidemic. human alphaherpesvirus 3 virion − a herpesvirus known to infect humans. it causes chickenpox (varicella), a disease most commonly affecting children, teens, and young adults, and shingles (herpes zoster) in adults. for example, chickenpox is endemic (steady state) in the united kingdom, but malaria is not. every year, there are a few cases of malaria reported in the uk, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus anopheles). consequently, the number of people infected by malaria is too variable to be called endemic. however, the number of people who get chickenpox in the uk varies little from year to year, so chickenpox is considered endemic in the uk. mathematical determination