compounds gave different ic50 value in the ring position in an in vitro activity. for an example there was a big difference if there was an n-pentyl group (ic50 = 13,3 nm), n-butyl (ic50 = 119 nm), phenyl with 2-furyl (ic50 = 0,720) or 3-thiophenyl (ic50 = 0,772). as seen in table 1, the in vitro activity increases depending on what compound is bonded to the distal ring (given that in the c-4 region of the proximal phenyl ring is a cl atom). table 1: differences in in vitro activity depending on which compound is bonded to the distal ring. ric50 (nm)activity 0.720in vitro activity improved* 1.14in vitro activity improved* 13.3as the number of carbons increases, the ic-50 value fluctuates 19.6in vitro activity decreased* 21.2in vitro activity decreased* *comparator to ethyl group (ic50 = 16,7) in table 2, the in vitro activity changes depending on the compound in the c-4 region of the proximal phenyl ring (x). small methyl groups or other halogen atoms in the c-4 position gave ic50 ranging from 0.72–36.7 (given that the phenyl with 2-furyl is in the ring position). table 2: differences in in vitro activity depending on what compound is in the c-4 region of the proximal phenyl ring. xic50 (nm) cl0.720 me1.43 f6.11 h22.6 cn36.7 table 3: difference in the ic50 value depending on how the thiazole ring relates (nothing else is changed in the structure (x = cl, r = phenyl with 2-furyl). compoundic50 (nm) 0.720 1.11