rtiox-276 rtiox-276 rtiox-276 is an orexin antagonist. rtiox-276 binds selectively to the orexin 1 receptor (ke = 8.5nm) and lacks significant affinity for the orexin 2 receptor (ke = > 10,000nm). rtiox-276 may have therapeutic utility for the treatment of cocaine addiction. in conditioned place preference studies, rtiox-276 attenuated the development of place preference in mice exposed to cocaine. rtiox-276identifiers iupac name 2-(1-(3,4-dimethoxybenzyl)-6-methoxy-7-(2,2,2-trifluoroethoxy)-3,4-dihydroisoquinolin-2(1h)-yl)-n-(pyridin-3-ylmethyl)acetamide chemical and physical dataformulac29h32f3n3o5molar mass559.586 g·mol−13d model (jsmol)interactive image smiles o=c(ncc1=cc=cn=c1)cn2c(cc3=cc(oc)=c(oc)c=c3)c4=cc(occ(f)(f)f)=c(oc)c=c4cc2