tiaprofenic acid tiaprofenic acid tiaprofenic acid is a nonsteroidal anti-inflammatory drug (nsaid) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. the typical adult dose is 300 mg twice daily. it is not recommended in children. tiaprofenic acidclinical datatrade namessurgam, surgamyl, tiaprofen, othersother names5-benzoyl-α-methyl-2-thiopheneacetic acidahfs/drugs.commicromedex detailed consumer informationpregnancycategory c routes ofadministrationby mouthatc codem01ae11 (who) legal statuslegal status uk: pom (prescription only) pharmacokinetic databioavailability90%metabolism10% liverelimination half-life1.5-2.5hexcretion50-80% urineidentifiers iupac name (rs)-2-(5-benzoyl-2-thienyl)propanoic acid cas number33005-95-7 ypubchem cid5468drugbankdb01600 ychemspider5269 yunii1ls1t6r34ckeggd01325 ychebichebi:32221 ychemblchembl365795 ycomptox dashboard (epa)dtxsid5023665 echa infocard100.046.649 chemical and physical dataformulac14h12o3smolar mass260.31 g·mol−13d model (jsmol)interactive imagechiralityracemic mixture smiles o=c(c1sc(cc1)c(c(=o)o)c)c2ccccc2 inchi inchi=1s/c14h12o3s/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9h,1h3,(h,16,17) ykey:guhprpjdbzhycj-uhfffaoysa-n y (verify) long-term use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other nsaids. it is contraindicated in patients with cystitis and urinary tract infections. it is sparingly metabolised in the liver to two inactive metabolites. most of the drug is eliminated unchanged in the urine. renal disease impairs excretion, and it should be used with caution in renal disease. it was patented in 1969 and approved for medical use in 1981. it is available in generic formulations. a sustained-release preparation is available. it is an isomer of suprofen.