quinisocaine quinisocaine quinisocaine (inn) or dimethisoquin (ban and usan) is a topical anesthetic used as an antipruritic. quinisocaineclinical dataahfs/drugs.cominternational drug namesatc coded04ab05 (who) identifiers iupac name 2-(3-butylisoquinolin-1-yl)oxy-n,n-dimethyl-ethanamine cas number86-80-6 npubchem cid6857chemspider6596 yunii772en3bh6ikeggd08462 ychemblchembl127643 ycomptox dashboard (epa)dtxsid8048525 echa infocard100.001.546 chemical and physical dataformulac17h24n2omolar mass272.392 g·mol−13d model (jsmol)interactive image smiles o(c2nc(cc1ccccc12)cccc)ccn(c)c inchi inchi=1s/c17h24n2o/c1-4-5-9-15-13-14-8-6-7-10-16(14)17(18-15)20-12-11-19(2)3/h6-8,10,13h,4-5,9,11-12h2,1-3h3 ykey:xnmynyscejbrpz-uhfffaoysa-n y ny (what is this?) (verify) synthesis thieme synthesis: patent: the henry reaction between phthalaldehydic acid (2-formylbenzoic acid) (1) and 1-nitropentane occurs by a mechanism that involves a hydroxy acid (2). expulsion of water then gives (3). reduction of the nitro group via catalytic hydrogenation leads to the amine, cid:158569430 (4). treatment of that amine with sodium hydroxide leads to ring opening of the lactone ring to the intermediary amino acid (5). this cyclises spontaneously to the lactam so that the product isolated from the reaction mixture is in fact the isoquinoline derivative, cid:154188092 (7). dehydration by means of strong acid gives 3-butylisocarbostyril (8). phosphorus oxychloride converts the oxygen function to the corresponding chloride via the enol forms 3-butyl-1-chloroisoquinoline (9). displacement of halogen with the sodium salt from 2-dimethylaminoethanol (10) affords dimethisoquin (11).