mallory body mallory body in histopathology, a mallory body, mallory-denk body, and mallory's hyaline, is an inclusion found in the cytoplasm of liver cells. mallory bodies are damaged intermediate filaments within the liver cells. micrograph showing a mallory body with the characteristic twisted-rope appearance (centre of image - within a ballooning hepatocyte). h&e stain. associated conditions mallory bodies are classically found in the livers of people suffering from alcohol-induced liver disease and were once thought to be specific for that. they are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%). they are a recognized feature of wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions. however, it has also been reported in certain other unrelated conditions. appearance mallory bodies are highly eosinophilic and thus appear pink on h&e stain. the bodies themselves are made up of intermediate cytokeratin 8/18 filament proteins that have been ubiquitinated, or bound by other proteins such as heat shock proteins, or p62/sequestosome 1. eponym it is named for the american pathologist frank burr mallory, who first described the structures in 1911. they were renamed as mallory-denk bodies in 2007 to honor the contribution of austrian pathologist helmut denk for the molecular analysis of the pathogenesis of mdbs.