abderhalden–kaufmann–lignac syndrome abderhalden–kaufmann–lignac syndrome abderhalden–kaufmann–lignac syndrome (akl syndrome), also called nephropathic cystinosis, is an autosomal recessive renal disorder of childhood comprising cystinosis and renal rickets. abderhalden–kaufmann–lignac syndromeother namesabderhalden–lignac–kaufmann diseaseabderhalden–kaufmann–lignac syndrome has an autosomal recessive pattern of inheritance. presentation affected children are developmentally delayed with dwarfism, rickets and osteoporosis. renal tubular disease is usually present causing aminoaciduria, glycosuria and hypokalemia. cysteine deposition is most evident in the conjunctiva and cornea. eponym it is named for emil abderhalden, eduard kaufmann and george lignac.