tilmicosin tilmicosin tilmicosin is a macrolide antibiotic. it is used in veterinary medicine for the treatment of bovine respiratory disease and enzootic pneumonia caused by mannheimia (pasteurella) haemolytica in sheep. in humans, tilmicosin causes fatal cardiotoxic effects at amounts greater than 1 milliliter when injected, something most commonly seen in veterinary personnel and farmers. tilmicosin, like most macrolides, is a calcium channel blocker. however, because micotil is formulated for animals like cows, it has exceptionally more epotent ca channel blocking effects in humans with a dose of .5 ml causing significant poisoning and a dose of 5-6 ml being lethal. tilmicosin names iupac name oxy}-11--2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxooxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-o-methyl-β-d-allopyranoside other names micotil; 20-deoxy-20-(3,5-dimethylpiperidin-1-yl)-desmycosin identifiers cas number 108050-54-0 y 3d model (jsmol) interactive image chembl chembl206342 chemspider 4445656 echa infocard 100.167.324 pubchem cid 5282521 unii xl4103x2e3 comptox dashboard (epa) dtxsid5046011 inchi inchi=1s/c46h80n2o13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54h,13,16-18,20-24h2,1-12h3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1key: jtsdbfgmplkdcd-xvfhvflvsa-ninchi=1/c46h80n2o13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54h,13,16-18,20-24h2,1-12h3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1key: jtsdbfgmplkdcd-xvfhvflvbd smiles o=c4\c=c\c(=c\(co1o(c)(o)(oc)1oc)(oc(=o)c(o)((o2o((o)(n(c)c)2o)c)(ccn3c(c)c(c)c3)c4c)c)cc)c properties chemical formula c46h80n2o13 molar mass 869.147 g·mol−1 solubility in water 566 mg/ml pharmacology atcvet code qj01fa91 (who) except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references