era-63 era-63 era-63, also known as org-37663, as well as 3-methylene-7α-methyl-17α-ethynylestra-5(10)-en-17β-ol, is a synthetic, steroidal estrogen and a selective agonist of the erα that was under development for the treatment of rheumatoid arthritis but was never marketed. the drug produced estrogenic effects but failed to show effectiveness for rheumatoid arthritis in a phase iia clinical study. a large clinical trial also found that prinaberel (erb-041), a selective erβ agonist, was ineffective in the treatment of rheumatoid arthritis in spite of activity in preclinical models. era-63clinical dataother names3-methylene-7α-methylethinylestradiol; 3-methylene-7α-methyl-17α-ethynylestra-5(10)-en-17β-olidentifiers iupac name (7r,8r,9s,13s,14s,17r)-17-ethynyl-7,13-dimethyl-3-methylidene-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopentaphenanthren-17-ol pubchem cid87921126chemspider8058857chemical and physical dataformulac22h30omolar mass310.481 g·mol−13d model (jsmol)interactive image smiles c1cc2=c(ccc(=c)c2)314cc(4(cc3)c)(c#c)o inchi inchi=1s/c22h30o/c1-5-22(23)11-9-19-20-15(3)13-16-12-14(2)6-7-17(16)18(20)8-10-21(19,22)4/h1,15,18-20,23h,2,6-13h2,3-4h3/t15-,18-,19+,20-,21+,22+/m1/s1key:ityurvxifiqgdb-ladqhvhvsa-n