acriflavine acriflavine acriflavine (inn: acriflavinium chloride) is a topical antiseptic. it has the form of an orange or brown powder. it may be harmful in the eyes or if inhaled. it is a dye and it stains the skin and may irritate. the hydrochloride form is more irritating than the neutral form. it is derived from acridine. commercial preparations are often mixtures with proflavine. it is known by a variety of commercial names. acriflavine sample of pure acriflavine names preferred iupac name 3,6-diamino-10-methylacridin-10-ium chloride other names acriflavinium chloride (inn) identifiers cas number 65589-70-0 y10597-46-3 (hcl) y 3d model (jsmol) interactive imageinteractive image chebi chebi:383703 n chembl chembl354349 n chemspider 391386 y21018 (hcl) y echa infocard 100.211.047 ec number 201-668-8 pubchem cid 44310115558347 (hcl) unii 1t3a50395t y1s73vw819c (hcl) y comptox dashboard (epa) dtxsid30988185 dtxsid4045848, dtxsid30988185 inchi inchi=1s/c14h13n3.clh/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;/h2-8h,1h3,(h3,15,16);1h nkey: kkajsjjfbsomgs-uhfffaoysa-n ninchi=1s/c14h13n3.c13h11n3.clh/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8h,1h3,(h3,15,16);1-7h,14-15h2;1hkey: pejlnxhanohnsu-uhfffaoysa-nkey: pejlnxhanohnsu-uhfffaoysa-n smiles .c1=c2c=c(n)c=cc2=cc2=c1c=c(n)c=c2.n1c3c(cc2c1cc(n)cc2)ccc(c3)n.nc3cc2(c1cc(n)ccc1cc2cc3)c properties chemical formula c14h14cln3 molar mass 259.74 g·mol−1 pharmacology atc code r02aa13 (who) qg01ac90 (who) except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references uses medical use acriflavine was developed in 1912 by paul ehrlich, a german medical researcher, and was used during the first world war against sleeping sickness and as a topical antiseptic. other uses acriflavine is used in biochemistry for fluorescently labeling high molecular weight rna. it is used as treatment for external fungal infections of aquarium fish. research in an animal model, acriflavine has been shown to inhibit hif-1, which prevents blood vessels growing to supply tumors with blood and interferes with glucose uptake and use. acriflavine might be effective in fighting common cold virus, and also aid the fight against increasingly antibiotic resistant bacteria because it can cure (remove) plasmids containing antimicrobial resistance genes from gram positive bacteria. since 2014, acriflavine has been undergoing testing as an antimalarial drug to treat parasites with resistance to quinine and modern anti-parasitic medicines. legal status australia acriflavine is a controlled substance in australia and dependent on situation, is considered either a schedule 5 (caution) or schedule 7 (dangerous poison) substance. the use, storage and preparation of the chemical is subject to strict state and territory laws.