apafant apafant apafant (web-2086, lsm-2613) is a drug which acts as a potent and selective inhibitor of the phospholipid mediator platelet-activating factor (paf). it was developed by structural modification of the thienotriazolodiazepine sedative drug brotizolam and demonstrated that paf inhibitory actions could be separated from activity at the benzodiazepine receptor. apafant was investigated for several applications involving inflammatory responses such as asthma and conjunctivitis but was never adopted for medical use, however it continues to be used in pharmacology research. apafantidentifiers iupac name 3-(4-(2-chlorophenyl)-9-methyl-6h-thienotriazolodiazepine-2-yl)-1-(4-morpholinyl)-1-propanone cas number105219-56-5pubchem cid65889iuphar/bps1859chemspider59298uniij613ni05svkeggd01652chebichebi:92490chemblchembl280164comptox dashboard (epa)dtxsid5048974 echa infocard100.220.442 chemical and physical dataformulac22h22cln5o2smolar mass455.96 g·mol−13d model (jsmol)interactive image smiles cc1=nn=c2n1c3=c(c=c(s3)ccc(=o)n4ccocc4)c(=nc2)c5=cc=cc=c5cl inchi inchi=1s/c22h22cln5o2s/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12h,6-11,13h2,1h3key:jgpjqforowsrrs-uhfffaoysa-n