clinical endocannabinoid deficiency syndrome clinical endocannabinoid deficiency syndrome clinical endocannabinoid deficiency (cecd) is a medical theory that proposes that a deficiency of endocannabinoids is the underlying pathophysiology of migraines, fibromyalgia, and irritable bowel syndrome. the deficiency may sometimes start in the womb as a result of maternal obesity. the nature of the syndrome and existence of cecd as a clinically meaningful condition have been called into question.