vilobelimab vilobelimab vilobelimab, sold under the brand name gohibic, is an investigational medication that is used for the treatment of covid-19. it is a human-mouse chimeric igg4 kappa antibody that targets human c5a in plasma. vilobelimabmonoclonal antibodytypewhole antibodysourcechimerictargetc5a (c5a)clinical datatrade namesgohibicother namesifx-1license data us dailymed: vilobelimab routes ofadministrationintravenousatc codenonelegal statuslegal status us: ℞-only via emergency use authorization (eua) identifierscas number2250440-41-4drugbankdb16416uniif5t0rf9zjakeggd11838chemical and physical dataformulac6456h9976n1716o2054s44molar mass145907.42 g·mol−1 the most common adverse reactions include pneumonia, sepsis, delirium, pulmonary embolism, hypertension, pneumothorax, deep vein thrombosis, herpes simplex, enterococcal infection, bronchopulmonary aspergillosis, hepatic enzyme increased, urinary tract infection, hypoxia, thrombocytopenia, pneumomediastinum, respiratory tract infection, supraventricular tachycardia, constipation, and rash. vilobelimab is a recombinant chimeric monoclonal igg4 antibody that specifically binds to the soluble human complement split product c5a after cleavage from c5 to block its interaction with the c5a receptor, both of which are components of the complement system thought to contribute to inflammation and worsening of covid-19. vilobelimab was granted an emergency use authorization (eua) by the us food and drug administration (fda) in april 2023. medical uses vilobelimab is authorized for use in hospitalized adults when initiated within 48 hours of receiving invasive mechanical ventilation or extracorporeal membrane oxygenation (artificial life support). vilobelimab is not approved by the fda for any indication, including for the treatment of covid-19. history the clinical trial supporting the authorization showed that participants treated with vilobelimab had a lower risk of death by day 28 and day 60 of treatment compared to placebo. society and culture names vilobelimab is the international nonproprietary name.