list of histologic stains that aid in diagnosis of cutaneous conditions list of histologic stains that aid in diagnosis of cutaneous conditions a number of histologic stains are used in the field of dermatology that aid in the diagnosis of conditions of or affecting the human integumentary system. positive histologic stains that aid in the diagnosis of conditions of or affecting the human integumentary system staincell, material, and/or structure(s) stainedcondition(s) in which stain is positive actin-specific enolaseinfantile digital fibromatosis ae1/ae3squamous cell carcinoma alcian bluelipoid proteinosispapular mucinosisscleredemapretibial myxedemamucopolysaccharidoses alizarin redcalcinosis cutis azure amast cellmastocytosis bcl-2basal cell carcinomaprimary cutaneous marginal zone lymphomadiffuse large b-cell lymphoma leg type bcl-6primary cutaneous follicular lymphoma berep4desmoplastic trichoepitheliomabasal cell carcinoma brown–brenneumycotic mycetoma cam 5.2merkel cell carcinoma ccr7melanoma carcinoembryonic antigen (cea)eccrine glandextramammary paget's diseasemicrocystic adnexal carcinomaeccrine poroma cd1alangerhans celllangerhans cell histiocytosisindeterminate cell histiocytosis cd4mycosis fungoidessézary syndrome cd5chronic lymphocytic leukemia cd8pagetoid reticulosis cd10renal cell carcinoma cd15hodgkin's disease cd20primary cutaneous marginal zone lymphomaprimary cutaneous follicular lymphomadiffuse large b-cell lymphoma leg type cd30 (ki-1)lymphomatoid papulosisprimary cutaneous anaplastic large cell lymphomaeosinophilic ulcer of the oral mucosahodgkin's disease cd31endothelial cellkaposi's sarcomaangiosarcomaintravascular large b-cell lymphoma cd34dermal dendritic celldesmoplastic trichoepitheliomaspindle cell lipomaangiosarcomadermatofibrosarcoma protuberansatypical fibroxanthomapleomorphic fibromaintravascular large b-cell lymphoma cd38plasma cellmultiple myelomaplasmablastic lymphomapagetoid reticulosis cd44merkel cell carcinoma cd56extranodal natural killer cell lymphomamerkel cell carcinoma cd68benign cephalic histiocytosisgeneralized eruptive histiocytosisindeterminate cell histiocytosisjuvenile xanthogranulomanecrobiotic xanthogranulomagiant cell reticulohistiocytomamulticentric reticulohistiocytosisxanthoma disseminatumrosai–dorfman diseaseatypical fibroxanthomamelanoma cd79aprimary cutaneous marginal zone lymphomaprimary cutaneous follicular lymphomadiffuse large b-cell lymphoma leg type cd117mast cellmastocytosis cd138plasma cellmultiple myelomaplasmablastic lymphoma cd207 (langerin)langerhans celllangerhans cell histiocytosis chloracetate esterase (leder)mast cellmastocytosis chromogranin amerkel cell carcinoma cystokeratin 7paget's disease (breast and extramammary) cytokeratin 20extramammary paget's disease of endodermal originmerkel cell carcinoma colloidal ironpapular mucinosisscleredemapretibial myxedema congo redamyloidosiscolloid milium crystal violetamyloidosiscolloid milium d2-40lymphangioma circumscriptum de galanthapseudogout dylonamyloidosis epithelial membrane antigen (ema)eccrine glandsebaceous glandpaget's diseaseextramammary paget's diseasemicrocystic adnexal carcinomasebaceous carcinomarenal cell carcinomaschwannoma factor viiidabska-type hemangioendotheliomaangiosarcoma factor xiiicutaneous focal mucinosis factor xiiiadermal dendritic celldermatofibromaepithelioid cell histiocytoma fiteleprosynocardiosis fontana-massoncryptococcus neoformanscryptococcus giemsamast cellmastocytosismucopolysaccharidoses gomori methenamine silverhistoplasma capsulatumblastomyces dermatitidiscoccidioides immitisparacoccidioides brasiliensishistoplasmosisblastomycosiscoccidioidomycosisparacoccidioidomycosis gross cystic disease fluid protein 15 (gcdfp-15)apocrine glandextramammary paget's disease of cutaneous origin ham56histiocytedermatofibroma hmb45gp100 (pmel17, silver protein)melanoma indiacryptococcus neoformanscryptococcus kp-1histiocytedermatofibroma lyve-1kaposi's sarcoma mac387histiocyte mart-1 (mart-1)melanoma masson's trichromeinfantile digital fibromatosis mel-5tyrp1melanoma methylene bluemast cellmastocytosisochronosis mib-1melanoma muscle-specific actinglomus tumordermatofibromainfantile myofibromatosis neurofilamentneurofibroma neuro-specific enolasemerkel cell carcinoma non-aqueous alcoholic eosin stain (naes)pseudogout oil red osebaceous carcinomaangiokeratoma corporis diffusumsubcutaneous fat necrosis of the newborn peanut agglutininbasal cell carcinoma phosphotungsten acid-hematoxylin (ptah)infantile digital fibromatosis pogoda redamyloidosis protein gene product 9.5 (pgp9.5)nerve sheath myxoma silver nitrateurate crystalgout sirius redamyloidosis smooth muscle actin (sma)angiomyxomaleiomyosarcoma sox10neuroectodermal neoplasms of neural crest origin, especially: melanoma, although desmoplastic melanomas may be only focally positive. nevus sudan ivleprosy sudan blacksebaceous carcinoma synaptophysinmerkel cell carcinoma s100melanocytelangerhans cellschwann cellchondrocyteadipocyteeccrine glandlangerhans cell histiocytosisindeterminate cell histiocytosisschwannomaneurofibromanerve sheath myxoma (cellular neurothekeoma)extraskeletal chondroma thioflavin tamyloidosiscolloid milium toluidine bluemast cellmastocytosismucopolysaccharidosespapular mucinosisscleredemapretibial myxedema tryptasemast cellmastocytosis tyrosinasetyrosinasemelanoma ulex eropaeus agglutinindabska-type hemangioendothelioma vegf-3dabska-type hemangioendothelioma vegfr-3kaposi's sarcoma verhoeff van giesoncollagenelastinelastosis perforans serpiginosaacquired perforating dermatosisperforating periumbilical calcific elastosispseudoxanthoma elasticum vimentinnon-specific mesenchymal componentsmelanomaglomus tumordermatofibromapleomorphic fibroma of the skinepithelioid cell histiocytoma von kossacalciumcalcinosis cutispseudoxanthoma elasticum wadeleprosy wrightblood cellstransient neonatal pustular melanosiserythema toxicum neonatorum>granuloma inguinale ziehl–neelsen_stainleprosy this is a dynamic list and may never be able to satisfy particular standards for completeness. you can help by adding missing items with reliable sources. footnotes the ziehl-neelson stain is positive in leprosy but notable for being negative with nocardiosis. fite stain is positive in leprosy and nocardiosis. melanoma stains positive with hmb45 with the exception of desmoplastic melanoma. staining of pustule contents in transient neonatal pustular melanosis will reveal numerous neutrophils staining of pustule in erythema toxicum neonatorum will reveal numerous eosinophils