orofaciodigital syndrome orofaciodigital syndrome orofaciodigital syndrome or oral-facial-digital syndrome is a group of at least 13 related conditions that affect the development of the mouth, facial features, and digits in between 1 in 50,000 to 250,000 newborns with the majority of cases being type i (papillon-league-psaume syndrome). orofaciodigital syndromeother namesorofaciodigital syndromespecialtyrheumatology, medical genetics type the different types are:s type i, papillon-league-psaume syndrome type ii, mohr syndrome type iii, sugarman syndrome type iv, baraitser-burn syndrome type v, thurston syndrome type vi, varadi-papp syndrome type vii, whelan syndrome type viii, oral-facial-digital syndrome, edwards type (not to be confused with edwards syndrome) type ix, ofd syndrome with retinal abnormalities type x, ofd with fibular aplasia type xi, gabrielli syndrome