tabimorelin tabimorelin tabimorelin (inn) (developmental code name nn-703) is a drug which acts as a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (ghsr) and growth hormone secretagogue, mimicking the effects of the endogenous peptide agonist ghrelin as a stimulator of growth hormone (gh) release. it was one of the first gh secretagogues developed and is largely a modified polypeptide, but it is nevertheless orally-active in vivo. tabimorelin produced sustained increases in levels of gh and insulin-like growth factor 1 (igf-1), along with smaller transient increases in levels of other hormones such as adrenocorticotropic hormone (acth), cortisol, and prolactin. however actual clinical effects in adults with growth hormone deficiency were limited, with only the most severely gh-deficient patients showing significant benefit, and tabimorelin was also found to act as a cyp3a4 inhibitor which could cause it to have undesirable interactions with other drugs. tabimorelinclinical dataother names((2e)-5-amino-5-methylhex-2-enoic acid n-methyl-n-((1r)-1-(n-methyl-n-((1r)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)amide)atc codenoneidentifiers iupac name n--n-methyl-3-(2-naphthyl)alanyl-n,nα-dimethyl-d-phenylalaninamide cas number193079-69-5 ypubchem cid9810101chemspider7985857uniil51cbe03kfchemical and physical dataformulac32h40n4o3molar mass528.697 g·mol−13d model (jsmol)interactive image smiles cc(c)(c/c=c/c(=o)n(c)(cc1=cc2=cc=cc=c2c=c1)c(=o)n(c)(cc3=cc=cc=c3)c(=o)nc)n inchi inchi=1s/c32h40n4o3/c1-32(2,33)19-11-16-29(37)35(4)28(22-24-17-18-25-14-9-10-15-26(25)20-24)31(39)36(5)27(30(38)34-3)21-23-12-7-6-8-13-23/h6-18,20,27-28h,19,21-22,33h2,1-5h3,(h,34,38)/b16-11+/t27-,28-/m1/s1key:wurgzwotgmldjp-zcyanpagsa-n (verify)