jwh-098 jwh-098 jwh-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. it is the indole 2-methyl derivative of a closely related compound jwh-081, but has markedly different affinity for the cb1 and cb2 receptors. while jwh-081 is around ten fold selective for cb1 over cb2, in jwh-098 this is reversed, and it is around four times weaker than jwh-081 at cb1 while being six times more potent at cb2, giving it a slight selectivity for cb2 overall. this makes jwh-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase cb2 affinity, but often at the expense of cb1 binding. jwh-098legal statuslegal status ca: schedule ii de: npsg (industrial and scientific use only) uk: class b us: schedule i identifiers iupac name 4-methoxynaphthalen-1-yl-(1-pentyl-2-methylindol-3-yl)methanone cas number316189-74-9pubchem cid45272116chemspider24628229uniit27v33219fcomptox dashboard (epa)dtxsid80185501 chemical and physical dataformulac26h27no2molar mass385.507 g·mol−13d model (jsmol)interactive image smiles cccccn(c1c)c2ccccc2c1c(=o)c(ccc3oc)c4ccccc34 inchi inchi=1s/c26h27no2/c1-4-5-10-17-27-18(2)25(22-13-8-9-14-23(22)27)26(28)21-15-16-24(29-3)20-12-7-6-11-19(20)21/h6-9,11-16h,4-5,10,17h2,1-3h3key:cntchebqqficnr-uhfffaoysa-n (verify) legal status in the united states, all cb1 receptor agonists of the 3-(1-naphthoyl)indole class such as jwh-098 are schedule i controlled substances. jwh-098 is illegal in russia, sweden, and the uk, although it is unclear whether it has any history of human use.