list of investigational anxiolytics list of investigational anxiolytics this is a list of investigational anxiolytics, or anxiolytics that are currently under development for clinical use but are not yet approved. chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. generalized anxiety disorder agomelatine (ago-178; valdoxan) – melatonin mt1 and mt2 receptor agonist, 5-ht2c receptor antagonist riluzole sublingual (bhv-0223) – undefined mechanism of action tgfk08aa – 5-ht1a receptor modulator tgw00aa (fkw00ga) – 5-ht1a receptor agonist, 5-ht2a receptor antagonist panic disorder darigabat (pf-06372865) – gabaa receptor positive allosteric modulator jnj-61393215 – orexin ox1 receptor antagonist nbtx-001 (xenon) – nmda receptor antagonist post-traumatic stress disorder 7-oxoprasterone (7-keto-dhea; hbl-9001) – "immunomodulator" / undefined mechanism of action acamprosate (snc-102) – undefined mechanism of action bnc-210 (iw-2143) – "gaba modulator" / undefined mechanism of action brexpiprazole (lu af41156, opc-34712; rexulti) – atypical antipsychotic / 5-ht1a, d2 and d3 receptor partial agonist and 5-ht2a, 5-ht2b, 5-ht7, α1-adrenergic, α2-adrenergic, and h1 receptor antagonist iloperidone (hp-873, ilo-522; fanapt, fiapta, zomaril) – atypical antipsychotic / 5-ht2a, 5-ht6, 5-ht7, d2, d3, d4, and α1-adrenergic receptor antagonist mdma (midomafetamine, 3,4-methylenedioxymethamphetamine, "ecstasy") – serotonin–norepinephrine–dopamine releasing agent and 5-ht1 and 5-ht2 receptor agonist – specifically under development as an aid to psychotherapy for post-traumatic stress disorder nbtx-001 (xenon) – nmda receptor antagonist pomaglumetad methionil (db-103, ly-2140023) – mglur2 and mglur3 agonist tianeptine oxalate/naloxone (tnx-601) – atypical μ-opioid receptor agonist social anxiety disorder fasedienol (aloradine; ph94b; 4-androstadienol) – vomeropherine / neurosteroid jnj-42165279 – faah inhibitor tgw00aa (fkw00ga) – 5-ht1a receptor agonist, 5-ht2a receptor antagonist vilazodone (emd-68843, sb-659746a; viibryd) – 5-ht1a receptor partial agonist and serotonin reuptake inhibitor others/unspecified avn-101 – 5-ht6 receptor antagonist bnc-210 (iw-2143) – "gaba modulator" / undefined mechanism of action / α7 subunit-containing nicotinic acetylcholine receptor antagonist deuterated etifoxine (grx-917) – translocator protein (tspo) agonist and gabaa receptor positive allosteric modulator jnj-42165279 – faah inhibitor jnj-61393215 – orexin ox1 receptor antagonist mp-20x – cb1 and 5-ht1a receptor modulator srx-246 – vasopressin v1a receptor antagonist