damgo damgo damgo (-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity. it was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin. structures of damgo bound to the µ opioid receptor reveal a very similar binding pose to morphinans. damgo names iupac name (2s)-2-amino]propanoyl]amino]acetyl]-methylamino]-n-(2-hydroxyethyl)-3-phenylpropanamide other names ala2-mephe4-glyol5-enkephalin, dago, damge identifiers cas number 78123-71-4 y 3d model (jsmol) interactive image chembl chembl38874 y chemspider 4575423 n iuphar/bps 1647 pubchem cid 5462471 comptox dashboard (epa) dtxsid30228775 inchi inchi=1s/c26h35n5o6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33h,12-16,27h2,1-2h3,(h,28,37)(h,29,35)(h,30,36)/t17-,21+,22+/m1/s1 nkey: hpzjmubdeambfi-wtnapckosa-n ninchi=1/c26h35n5o6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33h,12-16,27h2,1-2h3,(h,28,37)(h,29,35)(h,30,36)/t17-,21+,22+/m1/s1key: hpzjmubdeambfi-wtnapckobv smiles c(nc((n)cc1=cc=c(o)c=c1)=o)c(ncc(n((c(ncco)=o)cc2=cc=cc=c2)c)=o)=o properties chemical formula c26h35n5o6 molar mass 513.595 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references its structure is h-tyr-d-ala-gly-n-mephe-gly-ol. damgo has been used in experimental settings for the possibility of alleviating or reducing opiate tolerance for patients under the treatment of an opioid. such treatment on rats, adding damgo to morphine administration, showed that after seven days morphine had as much of an effect at the same dosage as the first day when administered together with damgo to the rats, whereas a separate control group of rats that were administered the same dosage of morphine over the course of the same week, but without damgo, displayed an increased tolerance and lessened analgesic efficacy toward the end of that week.