norepinephrine reuptake inhibitor norepinephrine reuptake inhibitor a norepinephrine reuptake inhibitor (nri, neri) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ari), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (net). this in turn leads to increased extracellular concentrations of norepinephrine and epinephrine and therefore can increase adrenergic neurotransmission. norepinephrine reuptake inhibitordrug classsynonymsadrenergic reuptake inhibitor