flavin group flavin group flavins (from latin flavus, "yellow") refers generally to the class of organic compounds containing the tricyclic heterocycle isoalloxazine or its isomer alloxazine, and derivatives thereof. the biochemical source of flavin is the vitamin riboflavin. the flavin moiety is often attached with an adenosine diphosphate to form flavin adenine dinucleotide (fad), and, in other circumstances, is found as flavin mononucleotide (or fmn), a phosphorylated form of riboflavin. it is in one or the other of these forms that flavin is present as a prosthetic group in flavoproteins. there are 18 key atoms in isoalloxazine that make up its characteristic three-ring structure. the r-group varies and differentiates various flavins. riboflavin the flavin group is capable of undergoing oxidation-reduction reactions, and can accept either one electron in a two-step process or two electrons at once. reduction is made with the addition of hydrogen atoms to specific nitrogen atoms on the isoalloxazine ring system: equilibrium between the oxidized (left) and totally reduced (right) forms of flavin. in aqueous solution, flavins are yellow-coloured when oxidized, taking a red colour in the semi-reduced anionic state or blue in the neutral (semiquinone) state, and colourless when totally reduced. the oxidized and reduced forms are in fast equilibrium with the semiquinone (radical) form, shifted against the formation of the radical: flox + flredh2 ⇌ flh• where flox is the oxidized flavin, flredh2 the reduced flavin (upon addition of two hydrogen atoms) and flh• the semiquinone form (addition of one hydrogen atom). in the form of fadh2, it is one of the cofactors that can transfer electrons to the electron transfer chain. photoreduction both free and protein-bound flavins are photoreducible, that is, able to be reduced by light, in a mechanism mediated by several organic compounds, such as some amino acids, carboxylic acids and amines. this property of flavins is exploited by various light-sensitive proteins. for example, the lov domain, found in many species of plant, fungi and bacteria, undergoes a reversible, light-dependent structural change which involves the formation of a bond between a cysteine residue in its peptide sequence and a bound fmn. fad fad flavin adenine dinucleotide is a group bound to many enzymes including ferredoxin-nadp+ reductase, monoamine oxidase, d-amino acid oxidase, glucose oxidase, xanthine oxidase, and acyl coa dehydrogenase. fadh/fadh2 fadh and fadh2 are reduced forms of fad. fadh2 is produced as a prosthetic group in succinate dehydrogenase, an enzyme involved in the citric acid cycle. in oxidative phosphorylation, two molecules of fadh2 typically yield 1.5 atp each, or three atp combined. fmn fmn flavin mononucleotide is a prosthetic group found in, among other proteins, nadh dehydrogenase, e.coli nitroreductase and old yellow enzyme.