congenital estrogen deficiency congenital estrogen deficiency congenital estrogen deficiency is a congenital form of hypoestrogenism in which the body is unable to produce or use estrogens. such conditions include: aromatase deficiency, a condition in which aromatase is absent and androgens cannot be converted into estrogens. estrogen insensitivity syndrome, a condition in which the estrogen receptor is defective and unable to respond to estrogens. congenital estrogen deficiencyother namesaromatase deficiencycongenital estrogen deficiency is inherited in an autosomal recessive manner.