chronic vesiculobullous hand eczema chronic vesiculobullous hand eczema chronic vesiculobullous hand eczema presents with lesions that may be hyperkeratotic, scaling, and fissures, and the "dyshidrosiform" pattern may be recognized only during exacerbations.</ref>: 79 females outnumber males by 3:1, and there is a tendency for the pruritic 1- to 2-mm vesicles to be most pronounced at the sides of the fingers.: 79 chronic vesiculobullous hand eczemaspecialtydermatology