perlapine perlapine perlapine, sold under the brand names hypnodine and pipnodine, is a hypnotic and sedative of the tricyclic group which is marketed in japan. it acts primarily as a potent antihistamine, and also has anticholinergic, antiserotonergic, antiadrenergic, and some antidopaminergic activity. the drug has relatively weak affinity for the dopamine d2 receptor (ic50 = 1,803 nm) and, in accordance, is said to be ineffective as an antipsychotic. however, it retains higher affinity for the dopamine d1 receptor (ic50 = 198 nm). its ic50 values are 19 nm for the α1-adrenergic receptor, 4,945 nm for the α2-adrenergic receptor, and 70 nm for the serotonin 5-ht2a receptor. perlapine is closely related to clotiapine, clozapine, fluperlapine, loxapine, and tilozepine. perlapineclinical datatrade nameshypnodine, pipnodineother namesaw-14233; hf-2333; mp-11; plp 100-127; 6-(4-methyl-1-piperazinyl)morphanthridineidentifiers iupac name 6-(4-methylpiperazin-1-yl)-11h-benzobenzazepine cas number1977-11-3pubchem cid16106chemspider15291unii4n8ujj27imkeggd01438chebichebi:31983chemblchembl340801comptox dashboard (epa)dtxsid1048758 echa infocard100.241.831 chemical and physical dataformulac19h21n3molar mass291.398 g·mol−13d model (jsmol)interactive image smiles cn1ccn(cc1)c2=nc3=cc=cc=c3cc4=cc=cc=c42 inchi inchi=1s/c19h21n3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9h,10-14h2,1h3key:pwrpuakxmqafcj-uhfffaoysa-n perlapine has been suggested as a potential ligand for certain dreadds.