chromonychia chromonychia chromonychia is an abnormality in color of the substance or surface of the nail plate or subungual tissues.: 658 chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia. although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, or in polychemotherapy also chromonychia is associated with aids. a significant association (p<0.05) was found between chromonychia and cd4 counts of below 200 per cubic millimeter.