list of largest selling pharmaceutical products list of largest selling pharmaceutical products best selling pharmaceuticals of u.s. market the top 5 best selling pharmaceuticals 2015-2019. sales in billion usd. rank drug main indication trade name 2015 2016 2017 2018 2019 1 adalimumab rheumatoid arthritis humira 10.1 13.5 16.3 18.4 21.4 2 apixaban anticoagulant eliquis 1.6 3.0 4.6 7.1 9.9 3 etanercept rheumatoid arthritis enbrel 7.2 7.6 7.9 8.0 8.1 4 ustekinumab psoriasis stelara 2.0 2.6 3.7 5.0 6.6 5 pembrolizumab oncology keytruda 0.4 0.7 2.2 4.3 6.5 best selling pharmaceuticals of 2017/18 the top 16 best selling pharmaceuticals of 2017/18. rank drug main indication trade name 2018 sales (million usd) 2017 sales (million usd) 1 adalimumab rheumatoid arthritis humira 19 936 18427 3 apixaban anticoagulant eliquis 9872 7395 4 lenalidomide multiple myeloma revlimid 9685 8187 5 nivolumab oncology opdivo 7570 5763 6 pembrolizumab oncology keytruda 7171 3809 7 etanercept rheumatoid arthritis enbrel 7126 7885 8 trastuzumab breast cancer herceptin 6981 7013 9 bevacizumab colon cancer avastin 6847 6686 10 rituximab non-hodgkin's lymphoma rituxan, mabthera 6750 7298 11 rivaroxaban anticoagulant xarelto 6589 6234 12 aflibercept eylea 6551 5830 13 infliximab remicade 5908 7152 14 pneumococcal conjugate vaccine prevnar 13 prevenar 13 5802 5601 15 ustekinumab stelara 5156 4011 16 pregabalin epilepsy lyrica 4970 5065 largest selling pharmaceutical products of 2015 drugs with sales above $5 billion in 2015 included: rank drug trade name type main indications company sales (usd millions/year) ∆ vs 2014 1 adalimumab humira biologic rheumatoid arthritis abbvie inc. 14,012 1,469 2 ledipasvir/sofosbuvir harvoni small molecule hepatitis c gilead sciences 13,864 11,737 3 etanercept enbrel biologic rheumatoid arthritis amgen pfizer 8,697 4,009 4 infliximab remicade biologic crohn's diseaserheumatoid arthritis johnson & johnson 8,355 1,487 5 rituximab mabthera rituxan biologic lymphoma leukemia autoimmune disorders roche genentech 7,115 1,456 6 insulin glargine lantus biologic diabetes mellitus sanofi 7,029 51 7 bevacizumab avastin biologic metastatic cancers roche genentech 6,751 270 8 trastuzumab herceptin biologic breast cancer roche genentech 6,603 265 9 lenalidomide revlimid small molecule multiple myeloma myelodysplastic syndromes celgene 5,801 821 10 sofosbuvir sovaldi small molecule hepatitis c gilead sciences 5,276 (5,007) 11 fluticasone propionate/salmeterol seretide advair small molecule asthma chronic obstructive pulmonary disease glaxosmithkline 5,227 (778) 12 rosuvastatin crestor small molecule cardiovascular diseases astrazeneca 5,017 (495) best selling pharmaceuticals of 2013 for the fourth quarter of 2013, the largest selling drugs were: rankbrand name(s)generic namesales q1 2014 sales ($000)change from q4 2013company(ies)disease/medical usefirst approval datepatent expiration date 1abilifyaripiprazole1,602,3292.23%genericpsychosis; depressionnov-20022014-oct 2humiraadalimumab1,561,8613.86%abbviecrohn's disease; rheumatoid arthritisdec-20022016-dec 3nexiumesomeprazole1,536,4350.74%genericgastrointestinal disordersmar-20002014-may 4crestorrosuvastatin1,333,5024.53%astrazeneca, shionogicholesterolnov-20022016-jul 5enbreletanercept1,189,8441.46%amgenrheumatoid arthritisnov-19982012-oct 6advair diskus, seretidefluticasone/salmeterol1,147,3302.65%glaxosmithklineasthmaaug-20002012-mar 8remicadeinfliximab994,020-2.71%centocor ortho biotech, inc., mitsubishi tanabe pharmacrohn's disease; rheumatoid arthritisaug-1998n/a 9lantus solostarinsulin glargine939,6919.39%sanofi-aventisdiabetes mellitus type 1 and 2apr-20002011-dec 10neulastapegfilgrastim854,508-4.90%amgenneutropeniajan-2002mon-20xx 11copaxoneglatiramer851,351-4.69%genericmultiple sclerosisdec-1996nov-2014 12rituxan, mabtherarituximab746,766-0.16%biogen idec, chugai pharmaceutical, genentech/rochenon-hodgkin’s lymphoma; rheumatoid arthritisnov-1997mon-20xx 13spirivatiotropium bromide726,0573.39%boehringer ingelheimchronic obstructive pulmonary diseaseapr-20022018-jul 14januviasitagliptin700,9413.63%merck & co., inc.diabetes mellitus type 2dec-19962017-nov 15lantusinsulin glargine685,4615.84%sanofi-aventisdiabetes mellitus type 1 and 2apr-2000dec-2011 16atriplaemtricitabine/tenofovir/efavirenz679,4180.36%gilead sciences, inc.hiv infectiondec-1996mar-2015 17cymbaltaduloxetine664,186-23.06%genericdepression; anxiety disordersaug-2004dec-2013 18avastinbevacizumab650,208-1.25%genentech/rochecancerfeb-2004mon-20xx 19lyricapregabalin624,7742.82%pfizerneuropathic painjul-2004jul-2019 20oxycontinoxycodone585,482-2.91%genericpaindec-1996mon-20xx 21celebrexcelecoxib580,3325.23%genericosteoarthritis; rheumatoid arthritisdec-1998may-2014 22epogenepoetin alfa503,493-2.08%amgenanemiajun-1989mon-20xx 23truvadatenofovir/emtricitabine542,8460.03%gilead scienceshiv infectionaug-2004mon-20xx 24diovanvalsartan533,924-2.80%generichypertensiondec-1996sep-2012 25levemirinsulin detemir424,1869.34%novo nordiskdiabetes mellitus type 1 and 2dec-1990mon-20xx 26gleevec, glivecimatinib498,1497.22%novartisleukemiamay-2001jan-2015 27herceptintrastuzumab473,6321.53%chugai pharmaceutical, genentech/rochebreast cancersep-1998mon-20xx 28vyvanselisdexamfetamine447,1889.39%shireattention deficit hyperactivity disorderapr-2008mon-20xx 29lucentisranibizumab460,621-0.84%genentechmacular degenerationdec-1990mon-20xx 30zetiaezetimibe444,7314.04%merck & co., schering-ploughcholesteroloct-20022017-oct 31combiventipratropium bromide/salbutamol391,40420.28%boehringer ingelheimchronic obstructive pulmonary diseaseoct-1996mon-20xx 32symbicortbudesonide/formoterol407,6469.63%astrazenecaasthmaaug-2000mon-20xx 33namendamemantine434,766-6.00%genericalzheimer's diseaseoct-2003apr-2014 34novolog flexpeninsulin aspart364,8707.84%novo nordiskdiabetes mellitus type 1 and 2oct-1996mon-20xx 35xareltorivaroxaban321,46218.72%bayeroral anticoagulantdec-1996sep-2012 36novologinsulin aspart344,2353.86%novo nordiskdiabetes mellitus type 1 and 2oct-1996mon-20xx 37humaloginsulin lispro304,8666.15%eli lilly and companydiabetes mellitus type 1 and 2apr-1996mon-20xx 38suboxonebuprenorphine321,892-2.11%reckitt benckiser pharmaceuticals inc.pain; opioid addictionaug-2000mon-20xx 40viagrasildenafil300,4633.26%pfizererectile dysfunctionmar-1998mar-2012 41seroquel xrquetiapine291,4942.22%genericpsychosis; depressionsep-1997mar-2012 33incivotelaprevir370,8990.00%johnson & johnsonhepatitis cdec-1990mon-20xx 35androgeltestosterone gel351,7375.47%genericlow testosterone levelsoct-2002oct-2016 37enoxaparinenoxaparin341,1846.55%genericdeep-vein thrombosismar-19932012-aug 38ritalinmethylphenidate327,3462.26%genericattention deficit hyperactivity disorderaug-2000mon-20xx 41proair hfasalbutamol306,46110.87%teva pharmaceuticalsasthma; chronic obstructive pulmonary diseaseoct-1996mon-20xx 43alimtapemetrexed302,7286.00%eli lilly and companycancerfeb-2004mon-20xx 44victozaliraglutide301,4149.59%novo nordiskdiabetes mellitus type 2may-1909mon-20xx 47synagispalivizumab289,7040.00%medimmunersv infectionfeb-1998aug-2012 48avonexinterferon beta 1a281,554-1.43%biogen idecmultiple sclerosismay-1996mon-20xx 49renvelasevelamer280,91721.44%generichyperphosphatemiaapr-2002apr-2016 50rebifinterferon beta 1a280,548-6.27%seronomultiple sclerosisfeb-1998mon-20xx 51cialistadalafil280,5184.58%eli lilly and company, lilly icoserectile dysfunctionnov-20022017-nov 52gilenyafingolimod272,7014.05%novartis corporationmultiple sclerosisfeb-20002007-jan 53nasonexmometasone272,3455.67%schering-ploughallergic rhinitisoct-19972018-oct 54stelaraustekinumab270,59812.47%johnson & johnsonpsoriasis; psoriatic arthritisapr-2000mon-20xx 55restasisciclosporin ophthalmic emulsion268,4636.30%allergan, inc, lilly icosdry eye syndromenov-2002mon-20xx 56budesonidebudesonide268,20126.81%genericasthmaaug-2000mon-20xx 57acetaminophen/hydrocodoneacetaminophen/hydrocodone264,8146.67%genericpainaug-2000mon-20xx 58flovent hfafluticasone propionate263,07213.97%glaxosmithklineasthmamar-1996mon-20xx 59lovazaomega-3 fatty acid ethyl esters258,1772.90%glaxosmithklinecholesteroljun-2001mon-20xx 60prezistadarunavir251,3723.54%johnson & johnsonhiv infectionjun-2006mon-20xx 61isentressraltegravir248,9240.72%merck & co., inc.hiv infectiondec-1998mon-20xx 62janumetsitagliptin/metformin247,1504.65%merck & co., inc.diabetes mellitus type 2dec-1998mon-20xx 63procrit, eprexepoetin alfa241,535-10.09%johnson & johnsonanemiadec-1990mon-20xx 64doxycyclinedoxycycline241,381-5.65%genericbacterial infectionsdec-1996nov-2011 65orenciaabatacept241,1491.65%bristol-myers squibb companyrheumatoid arthritisaug-2000mon-20xx 66amphetamine/dextroamphetamineamphetamine mixed salts240,4822.78%genericattention deficit hyperactivity disorder; narcolepsyfeb-2004mon-20xx 67vesicaresolifenacin240,4355.37%astellas pharma usoveractive bladderfeb-20002018-nov 68dexilantdexlansoprazole238,8977.57%takeda pharmaceuticals north america, incgastrointestinal disordersdec-2004jul-2012 69humalog kwikpeninsulin lispro238,41811.02%eli lilly and companydiabetes mellitus type 1 and 2apr-1996mon-20xx 70neupogenfilgrastim229,912-2.70%amgenneutropeniafeb-1991mon-20xx 71lidocainelidocaine225,9030.00%genericpainmar-1999mon-20xx 72lunestaeszopiclone225,1015.24%genericinsomniadec-2004april-2015 73fenofibratefenofibrate223,300-2.22%genericcholesterolfeb-1998mon-20xx 74zytigaabiraterone222,02611.86%janssen biotech, inc.prostate cancerdec-1998april-2015 75reyatazatazanavir217,793-1.38%bristol-myers squibbhiv infectionjan-2003mon-20xx 76sensiparcinacalcet216,65713.71%amgen inc.hyperparathyroidismapr-2000mon-20xx 77metoprololmetoprolol215,1112.99%generichypertensionjan-1992mon-20xx 78aciphexrabeprazole214,25110.03%janssen pharmaceuticals, inc, johnson & johnsongastrointestinal disordersaug-1999nov-2013 79synthroidlevothyroxine213,424-2.50%generichypothyroidismmay-1999expired 80avonex penolmesartan211,91713.59%biogen idec, forest laboratorieshypertensionapr-2002apr-2016 81prevnar 13pneumococcal conjugate vaccine209,3676.41%pfizerpneumococcal diseasefeb-2000jan-2007 82xolairomalizumab207,8911.91%genentech, novartisasthma2003mon-20xx 83lipitoratorvastatin207,5424.23%genericcholesteroldec-1996nov-2011 84levothyroxinelevothyroxine204,7550.00%generichypothyroidismaug-1990mon-20xx 85benicarolmesartan/hydrochlorothiazide203,3363.22%daiichi sankyohypertensionjun-1909mon-2016 86stribildelvitegravir/cobicistat/emtricitabine/tenofovir202,6420.00%gilead scienceshiv/aidsapr-2000mon-20xx 87zostavaxzostavax202,24015.17%eisai, merck & co.herpes zosteraug-1999may-2013 88pradaxadabigatran200,697-0.53%boehringer ingelheim, lilly icosoral anticoagulantoct-2010mon-20xx 89vytorinezetimibe/simvastatin199,625-3.02%merck & co., schering-ploughcholesteroljul-2004mon-20xx 90tamifluoseltamivir197,7180.00%chugai pharmaceutical, hetero drugs, rocheinfluenzaoct-1999mon-20xx 91xgevadenosumab197,7113.24%amgenosteoporosisnov-2010mon-20xx 92evistaraloxifene196,929-4.31%eli lilly and company, chugai pharmaceuticalosteoporosisdec-1997jan-2013 93xelodacapecitabine194,0446.52%genericcancerjun-1909mon-20xx 94aranespdarbepoetin alfa185,225-9.22%amgen inc.anemiajun-2001mon-20xx 95ventolin hfasalbutamol183,0600.00%glaxosmithklineasthma; chronic obstructive pulmonary diseasemay-1981mon-20xx 96divalproex sodiumvalproate181,5540.00%genericepilepsy and bipolar disorder jun-1909mon-20xx 97afinitoreverolimus180,7190.03%novartiscancerjun-1909mon-20xx 98betaseron, betaferoninterferon beta 1b179,216-3.72%bayermultiple sclerosisjul-1993mon-20xx 99adderall xramphetamine mixed salts177,5053.31%genericattention deficit hyperactivity disorderoct-2001mon-20xx 100compleraemtricitabine/rilpivirine/tenofovir disoproxil fumarate174,9330.00%gilead sciences, inc.hivjun-20xxmon-20xx