mine (chemotherapy) mine (chemotherapy) mine in the context of chemotherapy is an acronym for one of the chemotherapy regimens used for treatment of relapsed or refractory aggressive non-hodgkin's lymphoma and hodgkin's lymphoma. today this regimen is often combined with monoclonal antibody rituximab. in this case the regimen is called r-mine or mine-r. the -mine regimen consists of: rituximab - anti-cd20 monoclonal antibody that can kill both normal cd20-expressing b cells and malignant ones; mesna to prevent the development of hemorrhagic cystitis which may otherwise result from ifosfamide administration; ifosfamide - an alkylating antineoplastic agent from oxazafosforine group; mitoxantrone - a synthetic anthracycline analogue (anthraquinone) that is able to intercalate dna and thus prevent cell division (mitosis); etoposide - a topoisomerase inhibitor. dosing regimen drugdosemodedays rituximab375 mg/m2iv infusionday 1 mesna1330 mg/m2iv infusion over 1h together with ifosfamide, plus 500 mg po 4h after ifosfamidedays 1-3 ifosfamide1330 mg/m2iv infusion over 1hdays 1-3 mitoxantrone8 mg/m2iv infusionday 1 etoposide65 mg/m2iv infusion over 1hdays 1-3