thc-o-phosphate thc-o-phosphate thc-o-phosphate is a water-soluble organophosphate ester derivative of tetrahydrocannabinol (thc), which functions as a metabolic prodrug for thc itself. it was invented in 1978 in an attempt to get around the poor water solubility of thc and make it easier to inject for the purposes of animal research into its pharmacology and mechanism of action. the main disadvantage of thc phosphate ester is the slow rate of hydrolysis of the ester link, resulting in delayed onset of action and lower potency than the parent drug. pharmacologically, it is comparable to the action of psilocybin as a metabolic prodrug for psilocin. thc-o-phosphateidentifiers iupac name o-phosphoryl-δ8-tetrahydrocannabinol pubchem cid9865413chemspider21396139 ychemical and physical dataformulac21h31o5pmolar mass394.448 g·mol−13d model (jsmol)interactive image smiles op(o)(=o)oc3cc(ccccc)cc2oc(c)(c)c1c\c=c(\c)cc1c23 inchi inchi=1s/c21h31o5p/c1-5-6-7-8-15-12-18-20(19(13-15)26-27(22,23)24)16-11-14(2)9-10-17(16)21(3,4)25-18/h9,12-13,16-17h,5-8,10-11h2,1-4h3,(h2,22,23,24) ykey:svdbvzooosejcd-uhfffaoysa-n y (verify) thc phosphate ester is made by reacting thc with phosphoryl chloride using pyridine as a solvent, following by quenching with water to produce thc phosphate ester. in the original research the less active but more stable isomer δ8-thc was used, but the same reaction scheme could be used to make the phosphate ester of the more active isomer δ9-thc.