dimethyltrienolone dimethyltrienolone dimethyltrienolone (developmental code name ru-2420) is a synthetic, orally active, and extremely potent anabolic–androgenic steroid (aas) and 17α-alkylated 19-nortestosterone (nandrolone) derivative which was never marketed for medical use. it has among the highest known affinity of any aas for the androgen (and progesterone) receptors, and has been said to be perhaps the most potent aas to have ever been developed. dimethyltrienoloneclinical dataother namesru-2420; 7α,17α-dimethyltrenbolone; 7α,17α-dimethyl-δ9,11-19-nortestosterone; 7α,17α-dimethylestra-4,9,11-trien-17β-ol-3-oneroutes ofadministrationby mouthdrug classandrogen; anabolic steroid; progestogenidentifiers iupac name (7r,8s,13s,14s,17s)-17-hydroxy-7,13,17-trimethyl-1,2,6,7,8,14,15,16-octahydrocyclopentaphenanthren-3-one cas number10110-86-8 ypubchem cid101678228chemspider23208745unii8gp0j5637hchemblchembl128880chemical and physical dataformulac20h26o2molar mass298.426 g·mol−13d model (jsmol)interactive image smiles c1cc2=cc(=o)ccc2=c314cc(4(c=c3)c)(c)o inchi inchi=1s/c20h26o2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h6,8,11-12,17-18,22h,4-5,7,9-10h2,1-3h3/t12-,17+,18-,19+,20+/m1/s1key:memdjklepffnqs-zgpiavdesa-n pharmacology pharmacodynamics dimethyltrienolone is an extremely potent agonist of the androgen and progesterone receptors and hence aas and progestogen. in animal bioassays, it was shown to possess more than 100 times the anabolic and androgenic potency of the reference aas methyltestosterone. the drug is not a substrate for 5α-reductase and so is not potentiated or inactivated in so-called "androgenic" tissues like the prostate gland or skin. it is also not a substrate for aromatase and so has no estrogenic activity. due to its lack of estrogenicity, dimethyltrienolone has no propensity for causing estrogenic side effects like gynecomastia. because of its c17α methyl group and very high resistance to hepatic metabolism, dimethyltrienolone is said to be exceedingly hepatotoxic. relative affinities (%) of dimethyltrienolone and related steroids compoundchemical nameprarergrmr testosteronet1.0100<0.10.170.9 nandrolone19-nt20154<0.10.51.6 trenbolone∆9,11-19-nt74197<0.12.91.33 trestolone7α-me-19-nt50–75100–125 ?<1 ? normethandrone17α-me-19-nt100146<0.11.50.6 metribolone∆9,11-17α-me-19-nt208204<0.12618 mibolerone7α,17α-dime-19-nt214108<0.11.42.1 dimethyltrienolone∆9,11-7α,17α-dime-19-nt3061800.12252 values are percentages (%). reference ligands (100%) were progesterone for the pr, testosterone for the ar, estradiol for the er, dexa for the gr, and aldosterone for the mr. chemistry