rilmazafone rilmazafone rilmazafone (リスミー, rhythmy, previously known as 450191-s) is a water-soluble prodrug developed in japan. once metabolized, rilmazafone is converted into several benzodiazepine metabolites that have sedative and hypnotic effects. these metabolites induce impairment of motor function and have hypnotic properties. rilmazafoneclinical datatrade namesrhythmyother names5-(methyl)-1--n,n-dimethyl-1,2,4-triazole-3-carboxamideahfs/drugs.cominternational drug namesroutes ofadministrationoral (tablets)atc codenonelegal statuslegal status us: otc/uncontrolled rx-only (jp) pharmacokinetic dataelimination half-life10.5 hexcretionurineidentifiers iupac name 1--5--n,n-dimethyl-1h-1,2,4-triazole-3-carboxamide cas number99593-25-6 ypubchem cid5069chemspider4891 yuniicu3h37t766keggd08481 ycomptox dashboard (epa)dtxsid10244150 chemical and physical dataformulac21h20cl2n6o3molar mass475.33 g·mol−13d model (jsmol)interactive image smiles clc1=c(c(c2=cc(cl)=cc=c2n3c(cnc(cn)=o)=nc(c(n(c)c)=o)=n3)=o)c=cc=c1 inchi inchi=1s/c21h20cl2n6o3/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23/h3-9h,10-11,24h2,1-2h3,(h,25,30) ykey:kyhfrcpligodfh-uhfffaoysa-n y (verify) rilmazafone is not a benzodiazepine, since there is no benzene ring fused with a diazepine ring in the compound; in fact, the parent drug has no diazepine ring. it is therefore not classified as a benzodiazepine in several countries, including the united states, where it is not designated a controlled substance. rilmazafone has no effects on benzodiazepine receptors itself, nor does it produce any psychoactive effects prior to metabolism. however, once inside the body it is metabolized by aminopeptidase enzymes in the small intestine to form the principal active benzodiazepine 8-chloro-6-(2-chlorophenyl)-n,n-dimethyl-4h-1,2,4-triazolo benzodiazepine-2-carboxamide. as can be seen in the molecular diagram below, the principal metabolite contains a benzodiazepine ring structure (i.e., a benzene ring fused with a diazepine ring), unlike the parent compound (rilmazafone), which has no diazepine ring. rilmazafone active metabolite