isobucaine isobucaine isobucaine is a local anesthetic. isobucaineidentifiers iupac name benzoate cas number14055-89-1 ypubchem cid26427chemspider24619 yunii2xv8giv746comptox dashboard (epa)dtxsid20161440 chemical and physical dataformulac15h23no2molar mass249.354 g·mol−13d model (jsmol)interactive image smiles cc(c)cnc(c)(c)coc(=o)c1ccccc1 inchi inchi=1s/c15h23no2/c1-12(2)10-16-15(3,4)11-18-14(17)13-8-6-5-7-9-13/h5-9,12,16h,10-11h2,1-4h3 ykey:ygsfzbyomfzjpv-uhfffaoysa-n y synthesis synthesis: the reductive amination between aminomethyl propanol (1) and isobutanal (2) afforded n-isobutyl-1,1-dimethyl-2-hydroxyethanamine, cid:18315986 (3). acylation of the amine with benzoyl chloride hypothetically goes initially to the amide (4'). the acid catalysis used in the reaction leads to an n to o acyl migration to afford isobucaine (5).