biie-0246 biie-0246 biie-0246 is a drug used in scientific research which acts as a potent and selective antagonist for the neuropeptide y receptor y2. it was one of the first non-peptide y2-selective antagonists developed, and remains among the most widely used tools for studying this receptor. it has been used to demonstrate a role for the y2 subtype as a presynaptic autoreceptor limiting further neuropeptide y release, as well as modulating dopamine and acetylcholine release. it has also been shown to produce several behavioural effects in animals, including reducing alcohol consumption in addicted rats and anxiolytic effects, although while selective y2 agonists are expected to be useful as anorectics, biie-0246 did not appear to increase appetite when administered alone. biie-0246clinical dataother namesbiie-0246identifiers iupac name n--1-amino)carbonyl]butyl]-1-(2-azepin-11-yl)-1-piperazinyl]-2-oxoethyl)cyclopentaneacetamide cas number246146-55-4 ypubchem cid9811493iuphar/bps1547chemspider7987248 nuniin3z657h81xcomptox dashboard (epa)dtxsid40179360 chemical and physical dataformulac49h57n11o6molar mass896.066 g·mol−13d model (jsmol)interactive image smiles o=c3n(c1ccccc1)n(c2ccccc2)c(=o)n3ccnc(=o)(nc(=o)cc4(cccc4)cc(=o)n8ccn(c7c5c(cccc5)nc(=o)c6ccccc67)cc8)ccc/n=c(\n)n inchi inchi=1s/c49h57n11o6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43h,11-13,22-33h2,(h,52,64)(h,54,61)(h,55,63)(h4,50,51,53)/t40-,43?/m0/s1 nkey:rsjaxpuyvjkaaa-jpgjptaesa-n n ny (what is this?) (verify)