4'-hydroxynorendoxifen 4'-hydroxynorendoxifen 4'-hydroxynorendoxifen is a synthetic, nonsteroidal antiestrogen of the triphenylethylene group. it is a dual selective estrogen receptor modulator (serm) and aromatase inhibitor (ai), and was derived from tamoxifen, a serm, and norendoxifen, a metabolite of tamoxifen that has been found to act as an ai. the drug has been suggested for potential development as a treatment for estrogen receptor (er)-positive breast cancer. it was synthesized in 2015. 4'-hydroxynorendoxifenclinical dataother namesn,n-didesmethyl-4,4'-dihydroxytamoxifenidentifiers iupac name 4,4'-(1-(4-(2-aminoethoxy)phenyl)but-1-ene-1,2-diyl)diphenol chemspider58967386chemical and physical dataformulac24h25no3molar mass375.468 g·mol−13d model (jsmol)interactive image smiles ccc(=c(c1=cc=c(o)c=c1)c1=cc=c(occn)c=c1)c1=cc=c(o)c=c1 inchi inchi=1s/c24h25no3/c1-2-23(17-3-9-20(26)10-4-17)24(18-5-11-21(27)12-6-18)19-7-13-22(14-8-19)28-16-15-25/h3-14,26-27h,2,15-16,25h2,1h3key:vysgwfcgfktgqc-uhfffaoysa-n