isradipine isradipine isradipine (tradenames dynacirc, prescal) is a calcium channel blocker of the dihydropyridine class. it is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. isradipineclinical datatrade namesdynacircahfs/drugs.commonographmedlineplusa693048pregnancycategory c routes ofadministrationoralatc codec08ca03 (who) legal statuslegal status uk: pom (prescription only) us: ℞-only pharmacokinetic databioavailability15-24%protein binding95%metabolism100% hepaticelimination half-life8 hoursexcretion70% renal, 30% fecalidentifiers iupac name 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate cas number75695-93-1 ypubchem cid3784drugbankdb00270 ychemspider3652 yuniiyo1uk1s598keggd00349 ychemblchembl1648 ycomptox dashboard (epa)dtxsid4023179 echa infocard100.158.721 chemical and physical dataformulac19h21n3o5molar mass371.393 g·mol−13d model (jsmol)interactive image smiles o=c(oc)\c3=c(\n\c(=c(\c(=o)oc(c)c)c3c1cccc2nonc12)c)c inchi inchi=1s/c19h21n3o5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20h,1-5h3 ykey:hmjiyccijyronp-uhfffaoysa-n y (verify) it was patented in 1978 and approved for medical use in 1989. medical uses isradipine is given as either a 2.5 mg or 5 mg capsule. side effects common side effects include: dizziness warmth, redness, or tingly feeling under your skin headache weakness, tired feeling nausea, vomiting, diarrhea, upset stomach skin rash or itching serious side effects include: lightheadedness or fainting shortness of breath, especially from minimal physical activity swelling in the hands and feet rapid and/or heavy heartbeat chest pain drug interactions it is advised that those using isradipine not take anzemet (dolasetron), as both agents can cause a dose-dependent pr interval and qrs complex prolongation. itraconazole exhibits a negative inotropic effect on the heart and thus could spur an additive effect when used concomitantly with isradipine. onmel/sporanox also inhibits an important cytochrome liver enzyme (cyp 450 3a4) which is needed to metabolize isradipine and other calcium channel blockers. this will increase plasma levels of isradipine and could cause an unintentional overdose of the medication. caution is advised when administering both agents together. tizanidine demonstrates anti-hypertensive effects and should be avoided in patients taking isradipine due to the possibility of synergism between both medications. the anti-biotic rifampin lowered plasma concentrations of isradipine to below detectable limits. cimetidine increased isradipine mean peak plasma levels. a downward dose adjustment may be necessary with this particular instance of polypharmacy. severe hypotension was reported with fentanyl anesthesia when it was combined with other calcium channel blockers. even though isradipine, another calcium channel blocker, has not been used in conjunction with fentanyl anesthesia in any studies, caution is advised. note: there was no significant interaction between isradipine and warfarin (coumadin), isradipine and microzide hydrochlorothiazide, isradipine and lanoxin (digoxin), and isradipine and nitrostat (nitroglycerin). overdose symptoms of an isradipine overdose include: lethargy sinus tachycardia transient hypotension stereochemistry isradipine contains a stereocenter and consists of two enantiomers, more precisely atropisomers. this is a racemate, i.e. a 1: 1 mixture of ( r ) - and the ( s ) - form: enantiomers of isradipine cas-nummer: 84260-63-9 cas-nummer: 84260-64-0