in-stent restenosis as a result of neointimal hyperplasia and stent thrombosis, which led to the invention of drug-eluting stents with anti-proliferative drugs to combat in-stent restenosis. the first coronary angioplasty with a drug delivery stent system was performed by dr. stertzer and dr. luis de la fuente, at the instituto argentino de diagnóstico y tratamiento (english: argentina institute of diagnosis and treatment) in buenos aires, in 1999. ingemar henry lundquist invented the over-the-wire balloon catheter that is now used in the majority of angioplasty procedures in the world.