halofuginone halofuginone halofuginone, sold under the brand name halocur, is a coccidiostat used in veterinary medicine. it is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the chinese herb dichroa febrifuga (chang shan). collgard biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the u.s. food and drug administration. halofuginoneclinical datatrade nameshalocurahfs/drugs.cominternational drug namesatcvet codeqp51ax08 (who) legal statuslegal status eu: rx-only identifiers iupac name 7-bromo-6-chloro-3--2-oxopropyl]-4-quinazolinone cas number55837-20-2 ypubchem cid400772chemspider355164 nuniil31mm1385echemblchembl1199540 ncomptox dashboard (epa)dtxsid0048260 chemical and physical dataformulac16h17brcln3o3molar mass414.68 g·mol−13d model (jsmol)interactive image smiles o=c(cn3c=nc2=cc(br)=c(cl)c=c2c3=o)c1nccc1o inchi inchi=1s/c16h17brcln3o3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23h,1-4,7h2/t14-,15+/m0/s1 nkey:lvascwimlikxla-lsdhhaiusa-n n ny (what is this?) (verify) halofuginone inhibits the development of t helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of t cells which are involved in normal immune function. halofuginone therefore has potential for the treatment of autoimmune disorders. halofuginone is also an inhibitor of collagen type i gene expression and as a consequence it may inhibit tumor cell growth. halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme glutamyl-prolyl trna synthetase. inhibition of prolyl trna charging leads to the accumulation of uncharged prolyl trnas, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.