fenretinide fenretinide fenretinide (n-(4-hydroxyphenyl)retinamide; 4-hpr) (inn) is a synthetic retinoid derivative. retinoids are substances related to vitamin a. it has been investigated for potential use in the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, psoriasis, and has been found to also slow the production and accumulation of a toxin that leads to vision loss in stargardt's patients. fenretinide names iupac name n-(4-hydroxyphenyl)retinamide systematic iupac name (2e,4e,6e,8e)-n-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide identifiers cas number 65646-68-6 y 3d model (jsmol) interactive image chembl chembl7301 y chemspider 4450416 y drugbank db05076 y echa infocard 100.164.069 kegg d04162 y mesh fenretinide pubchem cid 5288209 unii 187ej7qexl y comptox dashboard (epa) dtxsid2032005 inchi inchi=1s/c26h33no2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28h,7,10,17h2,1-5h3,(h,27,29)/b9-6+,16-11+,19-8+,20-18+ ykey: akjhmtwegvyyse-fxilsdissa-n yinchi=1/c26h33no2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28h,7,10,17h2,1-5h3,(h,27,29)/b9-6+,16-11+,19-8+,20-18+key: akjhmtwegvyyse-fxilsdisbu smiles o=c(nc1ccc(o)cc1)\c=c(\c=c\c=c(\c=c\c2=c(\cccc2(c)c)c)c)c properties chemical formula c26h33no2 molar mass 391.546 g/mol except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). y verify (what is yn ?) infobox references in cancer studies, fenretinide treatment may cause ceramide (a wax-like substance) to build up in tumor cells and is associated with the accumulation of reactive oxygen species (ros), resulting in cell death through apoptosis and/or necrosis. fenretinide accumulates preferentially in fatty tissue such as the breast, which may contribute to the effectiveness of fenretinide against breast cancer. phase iii clinical trial data has suggested that fenretinide reduces breast cancer relapse in pre-menopausal women. common side effects associated with fenretinide treatment include skin dryness and night-blindness, which is reversible upon cessation of treatment. specific types of cancer under investigation include or have included ovarian, prostate, cervical, lung, renal, bladder, breast, glioma, skin, head and neck carcinoma, non-hodgkin's lymphoma, neuroblastoma, and ewing's sarcoma.