coagulation factor vii coagulation factor vii coagulation factor vii (ec 3.4.21.21, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade, and in humans is coded for by the gene f7. it is an enzyme of the serine protease class. once bound to tissue factor released from damaged tissues, it is converted to factor viia (or blood-coagulation factor viia, activated blood coagulation factor vii), which in turn activates factor ix and factor x. f7available structurespdbortholog search: pdbe rcsb list of pdb id codes4yt7, 1bf9, 1cvw, 1dan, 1dva, 1f7e, 1f7m, 1fak, 1ff7, 1ffm, 1j9c, 1jbu, 1kli, 1klj, 1o5d, 1qfk, 1w0y, 1w2k, 1w7x, 1w8b, 1wqv, 1wss, 1wtg, 1wun, 1wv7, 1ygc, 1z6j, 2a2q, 2aei, 2aer, 2b7d, 2b8o, 2bz6, 2c4f, 2ec9, 2f9b, 2fir, 2flb, 2flr, 2puq, 2zp0, 2zwl, 2zzu, 3ela, 3th2, 3th3, 3th4, 4ibl, 4ish, 4isi, 4jyu, 4jyv, 4jzd, 4jze, 4jzf, 4na9, 4ng9, 4nga, 4x8s, 4x8t, 4x8u, 4x8v, 4yt6, 4zxx, 4zxy, 4z6a, 4zma, 4ylq, 5i46identifiersaliasesf7, spca, coagulation factor viiexternal idsomim: 613878 mgi: 109325 homologene: 7710 genecards: f7 gene location (human)chr.chromosome 13 (human)band13q34start113,105,788 bpend113,120,685 bpgene location (mouse)chr.chromosome 8 (mouse)band8 a1.1|8 5.73 cmstart13,076,034 bpend13,085,809 bprna expression patternbgeehumanmouse (ortholog)top expressed inright lobe of liverventral tegmental areasecondary oocytevisceral pleurapancreatic ductal celldeltoid musclejejunumretinal pigment epitheliumoccipital lobesuperior frontal gyrustop expressed inleft lobe of liverright lung lobeyolk sacentorhinal cortexcarotid bodyleft lungsexually immature organismthoracic diaphragmdentate gyrusprimary motor cortexmore reference expression databiogpsmore reference expression datagene ontologymolecular function calcium ion binding endopeptidase activity peptidase activity protein binding serine-type peptidase activity hydrolase activity serine-type endopeptidase activity signaling receptor binding cellular component vesicle endoplasmic reticulum lumen plasma membrane extracellular region golgi lumen extracellular space serine-type peptidase complex collagen-containing extracellular matrix biological process hemostasis positive regulation of protein kinase b signaling response to organic cyclic compound positive regulation of cell migration positive regulation of platelet-derived growth factor receptor signaling pathway proteolysis response to estrogen positive regulation of leukocyte chemotaxis endoplasmic reticulum to golgi vesicle-mediated transport response to vitamin k positive regulation of blood coagulation response to nutrient levels animal organ regeneration response to growth hormone response to hormone blood coagulation, extrinsic pathway positive regulation of positive chemotaxis response to thyroid hormone protein processing blood coagulation response to 2,3,7,8-tetrachlorodibenzodioxine response to estradiol response to carbon dioxide response to genistein response to cholesterol circadian rhythm response to thyroxine response to thyroid stimulating hormone response to hypoxia response to anticoagulant response to astaxanthin response to thyrotropin-releasing hormone sources:amigo / quickgoorthologsspecieshumanmouseentrez215514068ensemblensg00000057593ensmusg00000031443uniprotp08709p70375refseq (mrna)nm_000131nm_001267554nm_019616nm_010172refseq (protein)np_000122np_001254483np_062562np_034302location (ucsc)chr 13: 113.11 – 113.12 mbchr 8: 13.08 – 13.09 mbpubmed searchwikidataview/edit humanview/edit mouse using genetic recombination a recombinant factor viia (eptacog alfa) (trade names include novoseven) has been approved by the fda for the control of bleeding in hemophilia. it is sometimes used unlicensed in severe uncontrollable bleeding, although there have been safety concerns. a biosimilar form of recombinant activated factor vii (aryoseven) is also available, but does not play any considerable role in the market. in april 2020, the us fda approved a new rfviia product, eptacog beta (sevenfact), the first bypassing agent (bpa) approved in more than 2 decades. as an rfviia product, eptacog beta works in a complex with tissue factor to activate factor x to xa, thereby bypassing fviii and fix. the activation of factor x to xa initiates the coagulation cascade’s common pathway, leading to clot formation at the site of hemorrhage. activated fvii binds to endothelial protein c receptor (epcr), which enhances hemostasis.14 one study showed that eptacog beta binds to epcr with 25% to 30% more affinity than eptacog alfa, displacing protein c from epcr binding sites and downregulating activated protein c generation, contributing to its hemostatic effect. physiology the main role of factor vii (fvii) is to initiate the process of coagulation in conjunction with tissue factor (tf/factor iii). tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. upon vessel injury, tissue factor is exposed to the blood and circulating factor vii. once bound to tf, fvii is activated to fviia by different proteases, among which are thrombin (factor iia), factor xa, ixa, xiia, and the fviia-tf complex itself. the complex of factor viia with tf catalyzes the conversion of factor ix and factor x into the active proteases, factor ixa and factor xa, respectively. the action of the factor is impeded by tissue factor pathway inhibitor (tfpi), which is released almost immediately after initiation of coagulation. factor vii, which was discovered around 1950, is vitamin k-dependent and produced in the liver. use of warfarin or similar anticoagulants decreases hepatic synthesis of fvii. a coagulation enzyme cascade may begin with a few molecules of factor xii and culminate in the activation of millions of times more fibrin molecules. structure