liver kidney microsomal type 1 antibody liver kidney microsomal type 1 antibody liver kidney microsomal type 1 antibody is an autoantibody associated with autoimmune hepatitis. it is one of the several subtypes of anti–liver-kidney microsome antibodies that are known. the frequent association of anti-lkm-1 antibodies and hepatitis c virus (hcv) infections and the probable existence of an infectious and autoimmune form of anti-lkm-1-associated hepatitis, requiring different therapeutical strategies, necessitates the exact determination of anti-lkm-1 specificities. immunofluorescence pattern of lkm1 antibodies on liver (left) and kidney (right). staining of proximal tubules can be observerved on the kidney, whereas distal tubules remain unstained.