11-hydroxyhexahydrocannabinol 11-hydroxyhexahydrocannabinol 11-hydroxyhexahydrocannabinol (11-oh-9α-hhc and 11-oh-9β-hhc, or alternatively 7-oh-hhc under the monoterpenoid numbering system) is an active metabolite of tetrahydrocannabinol (thc) and the major metabolite of the trace cannabinoid hexahydrocannabinol (hhc). 11-hydroxyhexahydrocannabinolidentifiers iupac name (6ar,9r,10ar)-9-(hydroxymethyl)-6,6-dimethyl-3-pentyl-6a,7,8,9,10,10a-hexahydrobenzochromen-1-ol cas number64663-39-4pubchem cid127684chemspider113271comptox dashboard (epa)dtxsid00983283 chemical and physical dataformulac21h32o3molar mass332.484 g·mol−13d model (jsmol)interactive image smiles cccccc1=cc(=c23c(cc3c(oc2=c1)(c)c)co)o inchi inchi=1s/c21h32o3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h11-12,15-17,22-23h,4-10,13h2,1-3h3/t15-,16-,17-/m1/s1key:lxsfnmqurhtpit-brwvuggusa-n in a pathway that parallels the metabolism of the thc family of cannabinoids, following ingestion hhc undergoes hepatic metabolism by cytochrome p450 (predominantly the cyp3a4 isozyme, with some contribution from cyp2c9 and cyp2c19) to a multitude of oxygenated derivatives, including 8-oh-hhc and 11-oh-hhc. c11-oxidation is the major pathway of thc and hhc metabolism. like other 11-oh cannabinoid metabolites, 11-oh-9β-hhc retains activity comparable to hhc itself while the 9α-isomer is significantly less active. however, upon formation it is rapidly metabolized further to the inactive 11-carboxylates, producing a shortened half-life within the body and lowering its bioavailability considerably through first-pass metabolism. the 11-oh-9β-hhc isomer is the structurally related methylene homologue of 11-nor-9β-hydroxyhexahydrocannabinol also known as 9-nor-9β-hydroxyhexahydrocannabinol. hu-243 is a synthetic analog of 11-oh-9β-hhc in which the natural n-pentyl side chain is replaced with a geminal-dimethylheptyl substitution. this significantly increases hu-243s binding affinity for the cb1 and cb2 receptors.