2,503 people received corneal transplants in the uk. history eduard zirm spanish-born eye surgeon ramón castroviejo successfully performed keratoplasty as early as 1936. the first cornea transplant was performed in 1905 by eduard zirm (olomouc eye clinic, now czech republic), making it one of the first types of transplant surgery successfully performed. another pioneer of the operation was ramón castroviejo. russian eye surgeon vladimir filatov's attempts at transplanting cornea started with the first try in 1912 and were continued, gradually improving until on 6 may 1931 he successfully grafted a patient using corneal tissue from a deceased person. he widely reported another transplant in 1936, disclosing his technique in full detail. in 1936, castroviejo did a first transplantation in an advanced case of keratoconus, achieving significant improvement in patient's vision. tudor thomas, a clinical teacher for the welsh national school of medicine, conceived the idea of a donor system for corneal grafts and an eye bank was established in east grinstead in 1955. advances in operating microscopes enabled surgeons to have a more magnified view of the surgical field, while advances in materials science enabled them to use sutures finer than a human hair. instrumental in the success of cornea transplants were the establishment of eye banks. these are organizations located throughout the world to coordinate the distribution of donated corneas to surgeons, as well as providing eyes for research. some eye banks also distribute other anatomical gifts. research high speed lasers blades are being replaced by high speed lasers in order to make surgical incisions more precise. these improved incisions allow the cornea to heal more quickly and the sutures to be removed sooner. the cornea heals more strongly than with standard blade operations. not only does this dramatically improve visual recovery and healing, it also allows the possibility for improvement in visual outcomes. since 2004, amnitrans eyebank in rotterdam, the netherlands, provides donor corneas pre-cut for advanced keratoplasty procedures, such as dsek, dsaek, fs-dsek and dmek. in 2007, seattle-based sightlife, one of the leading corneal tissue banks in the world, introduced a process for the preparation of donated corneal tissue using a femtosecond laser. this process is known as custom corneal tissue. dsek/dsaek/dmek endothelial keratoplasty (ek) was introduced by melles et al. in 1998. today there are two forms of ek: descemet's stripping (automated) endothelial keratoplasty (dsek/dsaek) in which the diseased descemet's membrane is removed and replaced by a healthy donor posterior transplant. the transplant tissue can be prepared by a surgeon's hand or ordered already prepared for surgery. ocular systems was the first organization to deliver prepared grafts for surgery in 2005. dsek/dsaek uses only a small incision that is either self-sealing or may be closed with a few sutures. the small incision offers several benefits over traditional methods of corneal transplant such as penetrating keratoplasty. because the procedure is less invasive, dsaek leaves the eye much stronger and less prone to injury than full-thickness transplants. new medical devices such as the endosaver (patent pending) are designed to ease process of inserting endothelial tissue into the cornea. additionally, dsaek has a more rapid rate of visual recovery. vision is typically restored in one to six months rather than one to two years. descemet membrane endothelial keratoplasty (dmek) is the most recent ek technique in which an isolated descemet's membrane is transplanted. the dmek procedure is a 'like for like' replacement of the diseased part of the cornea with visual rehabilitation to 20/40 or better in 90% of cases and 20/25 or better in 60% of cases within the first three months. rejection rates are lower (1%) and visual recovery is faster than any other form of corneal transplantation. in the uk (2013) dmek is available to patients under the national health service at the royal shrewsbury hospital, the calderdale and huddersfield nhs trust, and at worthing hospital (western sussex hospitals nhs foundation trust). not all patients with diseased corneas are candidates for endothelial keratoplasty. these procedures correct corneal endothelial failure, but are not able to correct corneal scarring, thinning, or surface irregularity. there is currently limited data on long-term survival of dmek grafts however the early indications are very positive. an upcoming systematic review will seek to compare the safety and effectiveness of dmek versus dsaek in people with corneal failure from fuchs' endothelial dystrophy and pseudophakic bullous keratopathy. stem cells there is a bioengineering technique that uses stem cells to create corneas or part of corneas that can be transplanted into the eyes. corneal stem cells are removed from a healthy cornea. they are collected and, through laboratory procedures, made into five to ten layers of cells that can be stitched into a patient's eye. the stem cells are placed into the area where the damaged cornea tissue has been removed. this is a good alternative for those that cannot gain vision through regular cornea transplants. a new development, announced by the university of cincinnati medical school in may 2007, would use bone marrow stem cells to regrow the cornea and its cells. this technique, which proved successful in mouse trials, would be of use to those with inherited genetic degenerative conditions of the cornea, especially if other means like a transplant are not feasible. it works better than a transplant because these stem cells keep their ability to differentiate and replicate, and so keep the disease from recurring, longer and better. biosynthetic corneas on 25 august 2010 investigators from canada and sweden reported results from the first 10 people in the world treated with the biosynthetic corneas. two years after having the corneas implanted, six of the 10 patients had improved vision. nine of the 10 experienced cell and nerve regeneration, meaning that corneal cells and nerves grew into the implant. to make the material, the researchers placed a human gene that regulates the natural production of collagen into specially programmed yeast cells. they then molded the resulting material into the shape of a cornea. this research shows the potential for these bioengineered corneas but the outcomes in this study were not nearly as good as those achieved with human donor corneas. this may become an excellent technique, but right now it is still in the prototype stage and not ready for clinical use. the results were published in the journal science translational medicine. society and culture cost a 2013 cost-benefit analysis by the lewin group for eye bank association of america, estimated an average cost of $16,500 for each corneal transplant.