azatadine azatadine azatadine (optimine) is a first-generation antihistamine and anticholinergic that was synthesized in 1973 by schering-plough, a former american pharmaceutical company. azatadineclinical datatrade namesoptimineahfs/drugs.commicromedex detailed consumer informationatc coder06ax09 (who) identifiers iupac name 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5h-benzocycloheptapyridine cas number3964-81-6 ypubchem cid19861iuphar/bps7119drugbankdb00719 ychemspider18709 yunii94z39nid6ckeggd07482 ychebichebi:2946 ychemblchembl946 ycomptox dashboard (epa)dtxsid6022636 chemical and physical dataformulac20h22n2molar mass290.410 g·mol−13d model (jsmol)interactive image smiles n4c3\c(=c1/ccn(c)cc1)c2ccccc2ccc3ccc4 inchi inchi=1s/c20h22n2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12h,8-11,13-14h2,1h3 ykey:sebmtiqkrhynit-uhfffaoysa-n y (verify) it was patented in 1967. it has been succeeded by both loratadine and desloratadine.: 53 and marketing approvals have been widely withdrawn.: 290