wilkinson's syndrome wilkinson's syndrome wilkinson's syndrome (also known as sclerotic pedicle sign) is a radiographic term which describes a unilaterally enlarged pedicle opposite a contralateral pars defect. the enlarged pedicle may due to stress hypertrophy, and changes may extend into the adjacent lamina and transverse processes. wilkinson's syndromeother namessclerotic pedicle signspecialtyradiologyusual onsetcongenital the characteristic radiographic feature of wilkinson's syndrome is a missing pedicle with a thick, sclerotic contralateral pedicle at the same level. this is sometimes referred to as a "winking owl sign".