craniofacial abnormality craniofacial abnormality craniofacial abnormalities are congenital musculoskeletal disorders which primarily affect the cranium and facial bones. "orafacial abnormality" redirects here. for other orofacial abnormalities, see mouth disease. craniofacial abnormalityhuman skullspecialtymedical genetics they are associated with the development of the pharyngeal arches. approximately, 5% of the uk or usa population present with dentofacial deformities requiring orthognathic surgery, jaw surgery, and orthodontics, brace therapy, as a part of their definitive treatment. notable conditions platybasia arrhinia - absence of the nose craniosynostosis - premature fusion of the cranial sutures cyclopia - one eye mobius syndrome - paralysis of the facial muscles