stability, on drug storage, are impacted due to the effects of radiation, long space flight durations, and microgravity. current solutions aim at frequent missions to resupply and restock medicines and commonly used drugs, however, this is not possible for long-term spaceflight to mars or other distant missions. in addition, due to the toll that spaceflight takes on the human body, medicine use by astronauts have been extensively studied. high rates of sleep medication are taken by astronauts to combat sleep deprivation, disturbances, and other sleep-related disorders caused by an increased presence of co2 in the international space station. medications for congestion and allergies, combined with headache-related medications, are also significantly used, primarily because of the cephalad fluid shifts caused by a transition to weightless environment. drug delivery technologies for outer space the need for developing drug delivery mechanisms that can accurately control dose frequency, concentration, and amount, for extreme conditions has grown as astronauts take on more extreme space exploration missions. regenerative therapies have also gained prominence in space medicine. microgravity conditions lead to bone loss due to repressing osteoblast growth, contributing to traumatic fractures, injuries, and extensive wound generation, requiring surgical intervention. using a concept called facilitated endogenous repair, scientists are developing scaffolds to deliver drugs or other agents to promote normal physiology at an injury site. in addition, tunable nanoparticles are also being investigated to maintain mechanical integrity when distribbuted to bone injuries for repair.