litoxetine litoxetine litoxetine (developmental code names sl 81-0385, ixa-001) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s but was never marketed. it acts as a potent serotonin reuptake inhibitor (ki for sert = 7 nm) and modest 5-ht3 receptor antagonist (ki = 315 nm). it has antiemetic activity, and unlike the selective serotonin reuptake inhibitors (ssris), appears to have a negligible incidence of nausea and vomiting. the drug is structurally related to indalpine. development of litoxetine for depression was apparently ceased in the late 1990s. however, as of march 2017, development of litoxetine has been reinitiated and the drug is now in the phase ii stage for the treatment of urinary incontinence. litoxetineclinical dataother namessl 81-0385; ixa-001atc codenoneidentifiers iupac name 4-(naphthalen-2-ylmethoxy)piperidine cas number86811-09-8pubchem cid65650chemspider59087unii9980st005gchemblchembl471036comptox dashboard (epa)dtxsid30235828 chemical and physical dataformulac16h19nomolar mass241.334 g·mol−13d model (jsmol)interactive image smiles c3cnccc3occ2cc1ccccc1cc2