complement component 6 complement component 6 complement component 6 is a protein that in humans is encoded by the c6 gene. c6available structurespdbhuman uniprot search: pdbe rcsb list of pdb id codes3t5o, 4a5w, 4e0sidentifiersaliasesc6, complement c6external idsomim: 217050 mgi: 88233 homologene: 47 genecards: c6 gene location (human)chr.chromosome 5 (human)band5p13.1start41,142,116 bpend41,261,438 bpgene location (mouse)chr.chromosome 15 (mouse)band15 a1|15 1.97 cmstart4,756,657 bpend4,844,449 bprna expression patternbgeehumanmouse (ortholog)top expressed inright lobe of liverright ventricleright uterine tubebody of pancreasbronchial epithelial cellpancreatic ductal cellgallbladderachilles tendonsynovial jointsubcutaneous adipose tissuetop expressed inleft lobe of liverright lung lobeleft lungleft lung lobewhite adipose tissuespleenmucosa of small intestinesubcutaneous adipose tissueduodenumskin of abdomenmore reference expression databiogpsn/agene ontologymolecular function protein binding cellular component extracellular region extracellular exosome membrane attack complex biological process positive regulation of activation of membrane attack complex immune system process complement activation in utero embryonic development cytolysis regulation of complement activation immune response positive regulation of angiogenesis complement activation, classical pathway positive regulation of complement activation innate immune response sources:amigo / quickgoorthologsspecieshumanmouseentrez72912274ensemblensg00000039537ensmusg00000022181uniprotp13671n/arefseq (mrna)nm_000065nm_001115131nm_016704refseq (protein)np_000056np_001108603n/alocation (ucsc)chr 5: 41.14 – 41.26 mbchr 15: 4.76 – 4.84 mbpubmed searchwikidataview/edit humanview/edit mouse complement component 6 is a protein involved in the complement system. it is part of the membrane attack complex which can insert into the cell membrane and cause the cell to lyse. people with c6 deficiency are prone to bacterial infection.