antazoline antazoline antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. to treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline. the drug is a histamine h1 receptor antagonist: selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine. antazolineclinical datatrade namesvasocon-aahfs/drugs.commicromedex detailed consumer informationroutes ofadministrationtopical (nasal, eye drops)atc coder01ac04 (who) r06ax05 (who)identifiers iupac name n-(4,5-dihydro-1h-imidazol-2-ylmethyl)-n-(phenylmethyl)aniline cas number91-75-8 ypubchem cid2200iuphar/bps7116drugbankdb08799 ychemspider2115 yuniidha8014ss1keggd07458 ychebichebi:84115 nchemblchembl1305 ycomptox dashboard (epa)dtxsid3022613 echa infocard100.001.904 chemical and physical dataformulac17h19n3molar mass265.360 g·mol−13d model (jsmol)interactive image smiles n\1=c(\ncc/1)cn(c2ccccc2)cc3ccccc3 inchi inchi=1s/c17h19n3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10h,11-14h2,(h,18,19) ykey:reyfjdpcwqrwaa-uhfffaoysa-n y ny (what is this?) (verify) a large study on people 65 years old or older linked the development of alzheimer's disease and other forms of dementia to the "higher cumulative" use of first-generation antihistamines, due to their anticholinergic properties.