brl-15,572 brl-15,572 brl-15,572 is a drug which acts as a selective antagonist for the serotonin receptor subtype 5-ht1d, with around 60x selectivity over other related receptors. the 5-ht1d receptor has a very similar pharmacology to the closely related 5-ht1b receptor, and most older ligands for these receptors bind to both subtypes with approximately equal affinity, so development of compounds such as brl-15572 which are able to selectively block the 5-ht1d subtype while leaving 5-ht1b unaffected, have been a significant advance which has helped scientists in researching the function of these serotonin receptor subtypes. one function of the 5-ht1d receptor this research has revealed is its role in modulating release of the neurotransmitter glutamate in the brain, as well as functions in regulation of cerebral blood pressure which are important in the pathogenesis of migraine headaches. brl-15,572clinical dataatc codenoneidentifiers iupac name 3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenyl-2-propanol cas number193611-72-2 ypubchem cid3654103iuphar/bps10chemspider2887678 nchemblchembl534232 ncomptox dashboard (epa)dtxsid4043983 chemical and physical dataformulac25h27cln2omolar mass406.95 g·mol−13d model (jsmol)interactive image smiles clc2cccc(c2)n1ccn(cc1)cc(o)c(c3ccccc3)c4ccccc4 ny (what is this?) (verify)