promegestone promegestone promegestone, sold under the brand name surgestone, is a progestin medication which is used in menopausal hormone therapy and in the treatment of gynecological disorders. it is taken by mouth. not to be confused with progesterone (medication). promegestoneclinical datatrade namessurgestoneother namespmg; r-5020; ru-5020; 17α,21-dimethyl-δ9-19-norprogesterone; 17α,21-dimethyl-19-norpregna-4,9-diene-3,20-dioneroutes ofadministrationby mouthdrug classprogestogen; progestinatc codeg03db07 (who) pharmacokinetic dataprotein bindingto albuminmetabolismliver (hydroxylation)metabolites• trimegestoneelimination half-lifepromegestone: ?trimegestone: 13.8–15.6 hoursidentifiers iupac name (8s,13s,14s,17s)-13,17-dimethyl-17-propionyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3h-cyclopentaphenanthren-3-one cas number34184-77-5pubchem cid36709chemspider33716unii9xe0v2sqyxkeggd08431chebichebi:73390chemblchembl196003comptox dashboard (epa)dtxsid4036510 echa infocard100.207.681 chemical and physical dataformulac22h30o2molar mass326.480 g·mol−13d model (jsmol)interactive image smiles ccc(=o)1(cc21(ccc3=c4ccc(=o)c=c4cc23)c)c inchi inchi=1s/c22h30o2/c1-4-20(24)22(3)12-10-19-18-7-5-14-13-15(23)6-8-16(14)17(18)9-11-21(19,22)2/h13,18-19h,4-12h2,1-3h3/t18-,19+,21+,22-/m1/s1key:qffcytlotyijmr-xmgtwhofsa-n side effects of promegestone include menstrual irregularities among others. promegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. it has weak antiandrogenic, glucocorticoid, and antimineralocorticoid activity and no other important hormonal activity. the medication is largely a prodrug of trimegestone. promegestone was first described in 1973 and was introduced for medical use in france in 1983. it has only been marketed in a few countries, including france, portugal, tunisia, and argentina. in addition to its use as a medication, promegestone has been widely used in scientific research as a radioligand of the progesterone receptor. medical uses promegestone is used in menopausal hormone therapy and in the treatment of gynecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea and other menstrual disorders, and premenstrual syndrome. it has also been used to treat benign breast disorders such as mastalgia (breast pain). promegestone tablets have a contraceptive effect and are used as a form of progestogen-only birth control, although it is not specifically licensed as such. side effects