lysergic acid 2,4-dimethylazetidide lysergic acid 2,4-dimethylazetidide lysergic acid 2,4-dimethylazetidide (la-ss-az, lsz) is an analog of lsd developed by the team led by david e. nichols at purdue university. it was developed as a rigid analog of lsd with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-ht2a receptor. there are three possible stereoisomers around the azetidine ring, with the (s,s)-(+) isomer being the most active, slightly more potent than lsd itself in drug discrimination tests using trained rats. lysergic acid 2,4-dimethylazetidideclinical dataother nameslysergic acid 2,4-dimethylazetidine, diazedine, lambda, lszroutes ofadministrationorallegal statuslegal status de: npsg (industrial and scientific use only) uk: class a illegal in denmark, france, sweden and switzerland identifiers iupac name quinoline-9-yl]-methanone ​freebase: (s,s)-isomer, freebasetartrate salt: (s,s)-isomer, tartrate saltcas numberfreebase: 470666-31-0 ytartrate salt: 470666-32-1 npubchem cidfreebase: 71301249chemspiderfreebase: 30773535 nuniifreebase: 8swj525w4rchemical and physical dataformulac21h25n3omolar mass335.451 g·mol−13d model (jsmol)freebase: interactive image smiles freebase: c1c(n1c(=o)2cn(3cc4=cnc5=cc=cc(=c45)c3=c2)c)c inchi freebase: inchi=1s/c21h25n3o/c1-12-7-13(2)24(12)21(25)15-8-17-16-5-4-6-18-20(16)14(10-22-18)9-19(17)23(3)11-15/h4-6,8,10,12-13,15,19,22h,7,9,11h2,1-3h3/t12-,13-,15+,19+/m0/s1 nkey:duknihftdaxjon-ctqrgltfsa-n n ny (what is this?) (verify) there have been several unconfirmed reports of lysergic acid 2,4-dimethylazetidide being synthesized in illicit laboratories and distributed on blotter paper or in liquid solution under names such as "diazedine" and "λ". in 2013 lsz also appeared on some designer drug and research chemical markets in the uk. lsz later gained international popularity through a small cluster of mail-order novel psychedelic shops that appeared in 2012. legal status on june 10, 2014 the uk advisory council on the misuse of drugs (acmd) recommended that lsz be specifically named in the uk misuse of drugs act as a class a drug despite not identifying any harm associated with its use. the uk home office accepted this advice and announced a ban of the substance to be enacted on 6 january 2015 as part of the misuse of drugs act 1971 (amendment) (no. 2) order 2014. lsz is illegal in switzerland as of december 2015, in denmark as of may 2015, and in sweden as of january 26, 2016.