aptazapine aptazapine aptazapine (developmental code name cgs-7525a) is a tetracyclic antidepressant (teca) that was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. it is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been shown to act as a 5-ht2 receptor antagonist and h1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. based on its pharmacological profile, aptazapine may be classified as a noradrenergic and specific serotonergic antidepressant (nassa). aptazapineclinical dataatc codenoneidentifiers iupac name 2-methyl-1,3,4,14b-tetrahydro-2h,10h-pyrazinopyrrolobenzodiazepine cas number71576-40-4 npubchem cid51355chemspider46513 yunii240j927j1rkeggd02972 ychemblchembl336712 ychemical and physical dataformulac16h19n3molar mass253.349 g·mol−13d model (jsmol)interactive image smiles c42c(n3c(c1cccn1c2)cn(cc3)c)cccc4 inchi inchi=1s/c16h19n3/c1-17-9-10-19-14-6-3-2-5-13(14)11-18-8-4-7-15(18)16(19)12-17/h2-8,16h,9-12h2,1h3 ykey:mnhdderdsnzcck-uhfffaoysa-n y ny (what is this?) (verify)