acrokeratoelastoidosis of costa acrokeratoelastoidosis of costa acrokeratoelastoidosis of costa is a familial condition characterized by multiple keratotic papules on the dorsum of the hands and feet, palms, soles, in which electron microscopy shows rarified, abnormal elastic tissue.: 993 : 214 acrokeratoelastoidosis of costaother nameskeratoelastoidosis marginalisautosomal dominant is the inheritance manner for this conditionspecialtydermatology it was characterized in 1953. treatments such as liquid nitrogen, salicylic acid, tretinoin, and prednisone have been tried, though with limited success.