tooth regeneration tooth regeneration tooth regeneration is a stem cell based regenerative medicine procedure in the field of tissue engineering and stem cell biology to replace damaged or lost teeth by regrowing them from autologous stem cells. as a source of the new bioengineered teeth, somatic stem cells are collected and reprogrammed to induced pluripotent stem cells which can be placed in the dental lamina directly or placed in a reabsorbable biopolymer in the shape of the new tooth. history young et al. first demonstrated in 2002 that teeth could be regenerated from cells.