anamorelin anamorelin anamorelin (inn) (developmental code names ono-7643, rc-1291, st-1291), also known as anamorelin hydrochloride (usan, jan), is a non-peptide, orally-active, centrally-penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (ghsr) with appetite-enhancing and anabolic effects which is under development by helsinn healthcare sa for the treatment of cancer cachexia and anorexia. anamorelinclinical dataroutes ofadministrationoralatc codenonepharmacokinetic dataelimination half-life6–7 hoursidentifiers iupac name 2-amino-n-piperidin-1-yl]-3-(1h-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide cas number249921-19-5pubchem cid9828911chemspider8004650uniidd5rba1nkfcomptox dashboard (epa)dtxsid20179702 chemical and physical dataformulac31h42n6o3molar mass546.716 g·mol−13d model (jsmol)interactive image smiles cc(c)(c(=o)nc(cc1=cnc2=cc=cc=c21)c(=o)n3cccc(c3)(cc4=cc=cc=c4)c(=o)n(c)n(c)c)n inchi inchi=1s/c31h42n6o3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33h,11,16-19,21,32h2,1-5h3,(h,34,39)/t26-,31-/m1/s1key:vqpfsiruepqqpp-mxbottglsa-n anamorelin significantly increases plasma levels of growth hormone (gh), insulin-like growth factor 1 (igf-1), and insulin-like growth factor-binding protein 3 (igfbp-3) in humans, without affecting plasma levels of prolactin, cortisol, insulin, glucose, adrenocorticotropic hormone (acth), luteinizing hormone (lh), follicle-stimulating hormone (fsh), or thyroid-stimulating hormone (tsh). in addition, anamorelin significantly increases appetite, overall body weight, lean body mass, and muscle strength, with increases in body weight correlating directly with increases in plasma igf-1 levels. as of february 2016, anamorelin has completed phase iii clinical trials for the treatment of cancer cachexia and anorexia associated with non-small-cell lung carcinoma. on 18 may 2017, the european medicines agency recommended the refusal of the marketing authorisation for the medicinal product, intended for the treatment of anorexia, cachexia or unintended weight loss in patients with non-small cell lung cancer. helsinn requested a re-examination of the initial opinion. after considering the grounds for this request, the european medicines agency re-examined the opinion, and confirmed the refusal of the marketing authorisation on 14 september 2017. the european medicines agency concluded that the studies show a marginal effect of anamorelin on lean body mass and no proven effect on hand grip strength or patients’ quality of life. in addition, following an inspection at clinical study sites, the agency considered that the safety data on the medicine had not been recorded adequately. therefore, the agency was of the opinion that the benefits of anamorelin did not outweigh its risks.