dota-tate dota-tate dota-tate names other names dota-(tyr3)-octreotate identifiers cas number 177943-89-4 y 3d model (jsmol) interactive image chemspider 9345959 pubchem cid 11170867 unii 99r86y6v0m y comptox dashboard (epa) dtxsid60170399 inchi inchi=1s/c65h90n14o19s2/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82h,8-9,14,19-30,32-37,66h2,1-2h3,(h,68,83)(h,69,93)(h,70,94)(h,71,92)(h,72,91)(h,73,96)(h,74,90)(h,75,95)(h,84,85)(h,86,87)(h,88,89)(h,97,98)/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+/m1/s1key: qvflvlmyxxnjdt-csbvgunjsa-ninchi=1/c65h90n14o19s2/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82h,8-9,14,19-30,32-37,66h2,1-2h3,(h,68,83)(h,69,93)(h,70,94)(h,71,92)(h,72,91)(h,73,96)(h,74,90)(h,75,95)(h,84,85)(h,86,87)(h,88,89)(h,97,98)/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+/m1/s1key: qvflvlmyxxnjdt-csbvgunjbn smiles c(1c(=o)n(cssc(c(=o)n(c(=o)n(c(=o)n(c(=o)n1)ccccn)cc2=cnc3=cc=cc=c32)cc4=cc=c(c=c4)o)nc(=o)(cc5=cc=cc=c5)nc(=o)cn6ccn(ccn(ccn(cc6)cc(=o)o)cc(=o)o)cc(=o)o)c(=o)n((c)o)c(=o)o)o properties chemical formula c65h90n14o19s2 molar mass 1435.63 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references dota-tate (dotatate, dota-octreotate, oxodotreotide, dota-(tyr3)-octreotate, and dota-0-tyr3-octreotate) is an eight amino acid long peptide, with a covalently bonded dota bifunctional chelator. dota-tate can be reacted with the radionuclides gallium-68 (t1/2 = 68 min), lutetium-177 (t1/2 = 6.65 d) and copper-64 (t1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (pet) imaging or radionuclide therapy. 177lu dota-tate therapy is a form of peptide receptor radionuclide therapy (prrt) which targets somatostatin receptors (ssr). in that form of application it is a form of targeted drug delivery. chemistry and mechanism of action dota-tate is a compound containing tyrosine3-octreotate, an ssr agonist, and the bifunctional chelator dota (tetraxetan). ssrs are found with high density in numerous malignancies, including cns, breast, lung, and lymphatics. the role of ssr agonists (i.e. somatostatin and its analogs such as octreotide, somatuline and vapreotide) in neuroendocrine tumours (nets) is well established, and massive ssr overexpression is present in several nets. (tyr3)-octreotate binds the transmembrane receptors of nets with highest activity for ssr2 and is actively transported into the cell via endocytosis, allowing trapping of the radioactivity and increasing the probability of the desired double-strand dna breakage (for tumour control). trapping improves the probability of this kind of effect due to the relatively short range of the beta particles emitted by 177lu, which have a maximum range in tissue of <2 mm. bystander effects include cellular damage by free radical formation. clinical applications gallium-68 dota-tate further information: gallium scan § gallium dota scans 68ga dota-tate (gallium-68 dotatate, gatate) is used to measure tumor ssr density and whole-body bio-distribution via pet imaging. 68ga dota-tate imagery has a much higher sensitivity and resolution compared to 111in octreotide gamma camera or spect scans, due to intrinsic modality differences. copper-64 dota-tate copper (64cu) oxodotreotide or copper cu 64 dotatate, sold under the brand name detectnet, is a radioactive diagnostic agent indicated for use with positron emission tomography (pet) for localization of somatostatin receptor positive neuroendocrine tumors (nets) in adults. it was fda approved in september 2020. these are the same indications for as the gallium dota-tate scans, but cu-64 has advantages over ga-68 in having a 12-hour half life rather than the much shorter one-hour half life of ga-68, making it easier to transport from central production locations. lutetium-177 dota-tate main article: lutetium (177lu) oxodotreotide