imolamine imolamine imolamine (inn, ban; brand names angolon, angoril, circuline, irri-cor, irrigor, coremax) is a coronary vasodilator which is used in the treatment of angina pectoris and as a local anesthetic. imolamineclinical datatrade namesangolon, angoril, circuline, irri-cor, irrigor, coremaxatc codec01dx09 (who) identifiers iupac name diethylamine cas number318-23-0 n 15823-89-9 (hcl)pubchem cid27501drugbankdb09284 ychemspider10669810 nuniik5f4ru5vqjkeggd07159 ychemblchembl2104282 necha infocard100.005.699 chemical and physical dataformulac14h20n4omolar mass260.341 g·mol−13d model (jsmol)interactive image smiles ccn(cc)ccn2c(=n)o\n=c2\c1ccccc1 inchi inchi=1s/c14h20n4o/c1-3-17(4-2)10-11-18-13(16-19-14(18)15)12-8-6-5-7-9-12/h5-9,15h,3-4,10-11h2,1-2h3 nkey:mgspdrwoucpknz-uhfffaoysa-n n ny (what is this?) (verify) use patents: synthesis butalamine has very similar synthesis but is alkylated on the alternate nitrogen position. thieme patent the reaction of benzoylchloride oxime (2) with cyanamide (3) gives 3-phenyl-1,2,4-oxadiazol-5-amine (4). alkylation with 2-chlorotriethylamine (5) in the presence of koh base occurs at the endocyclic ring nitrogen completing the synthesis of imolamine (6). efforts towards onepot method (section 2.5 & 2.6).