valpromide valpromide valpromide (marketed as depamide by sanofi-aventis) is a carboxamide derivative of valproic acid used in the treatment of epilepsy and some affective disorders. it is rapidly metabolised (80%) to valproic acid (another anticonvulsant) but has anticonvulsant properties itself. it may produce more stable plasma levels than valproic acid or sodium valproate and may be more effective at preventing febrile seizures. however, it is over one hundred times more potent as an inhibitor of liver microsomal epoxide hydrolase. this makes it incompatible with carbamazepine and can affect the ability of the body to remove other toxins. valpromide is no safer during pregnancy than valproic acid. valpromide names preferred iupac name 2-propylpentanamide identifiers cas number 2430-27-5 n 3d model (jsmol) interactive image chebi chebi:74562 chembl chembl93836 y chemspider 64264 y drugbank db04165 y echa infocard 100.017.632 ec number 219-394-2 kegg d02766 n mesh dipropylacetamide pubchem cid 71113 unii rua6cwu76g y comptox dashboard (epa) dtxsid1023734 inchi inchi=1s/c8h17no/c1-3-5-7(6-4-2)8(9)10/h7h,3-6h2,1-2h3,(h2,9,10) ykey: omomuftzptxchp-uhfffaoysa-n y smiles cccc(ccc)c(n)=o properties chemical formula c8h17no molar mass 143.230 g·mol−1 appearance white crystals melting point 125 °c (257 °f; 398 k) log p 2.041 pharmacology atc code n03ag02 (who) hazards ghs labelling: pictograms signal word warning hazard statements h302 lethal dose or concentration (ld, lc): ld50 (median dose) 438 mg kg−1 (intraperitoneal, mouse)890.0 mg kg−1 (oral, rat) related compounds related amides valnoctamide except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references valpromide is formed through the reaction of valproic acid and ammonia via an intermediate acid chloride. in pure form, valpromide is a white crystalline powder and has a melting point 125–126 °c. it is soluble only in hot water. it is available on the market in some european countries.