losigamone losigamone losigamone (inn) is an investigational drug for the treatment of epilepsy. it has been studied as an add-on treatment for partial seizures. phase iii clinical trials were conducted around the year 2000. losigamoneclinical dataatc codenonelegal statuslegal status investigational identifiers iupac name (2r)-2--3-methoxy-2h-furan-5-one cas number112856-44-7 npubchem cid6918049chemspider5293266 nunii84r8o3qm2gchemical and physical dataformulac12h11clo4molar mass254.67 g·mol−13d model (jsmol)interactive image smiles clc1ccccc1c(o)c2oc(=o)c=c2oc inchi inchi=1s/c12h11clo4/c1-16-9-6-10(14)17-12(9)11(15)7-4-2-3-5-8(7)13/h2-6,11-12,15h,1h3/t11-,12-/m0/s1 nkey:icdnywjqgwnlfp-ryudhwbxsa-n n ny (what is this?) (verify) mechanism of action the mechanism of action is not known. data regarding the interaction of losigamone with gaba receptors are inconsistent: it increases gaba-induced chloride influx in spinal cord neuron cultures, but has no significant influence on gabaergic inhibitory postsynaptic potentials in hippocampal slices. interaction with potassium and sodium channels has been proposed. results from both in vitro and in vivo experiments confirm that the pharmacological activity profiles of the two losigamone enantiomers are not identical and suggest further that excitatory amino acid-mediated processes are involved in the mode of action of (+)-losigamone (the compound shown in the image) whereas (–)-losigamone does not possess such properties.