autoimmune polyendocrine syndrome type 2 autoimmune polyendocrine syndrome type 2 autoimmune polyendocrine syndrome type 2, a form of autoimmune polyendocrine syndrome also known as aps-ii, or pas ii, is the most common form of the polyglandular failure syndromes. pas ii is defined as the association between autoimmune addison's disease and either autoimmune thyroid disease, type 1 diabetes, or both. it is heterogeneous and has not been linked to one gene. rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (hla-dq2, hla-dq8 and hla-dr4). aps-ii affects women to a greater degree than men.