also require higher doses of ovulation-inducing agents. in vitro fertilization, including controlled ovarian hyperstimulation. in vitro maturation is letting ovarian follicles mature in vitro, and this technique can potentially be an alternative both to anovulation reversal and oocyte release triggering. rather, oocytes can mature outside the body, such as prior to ivf. hence, no (or at least a lower dose of) gonadotropins have to be injected in the body. however, there still isn't enough evidence to prove the effectiveness and security of the technique. laparoscopic ovarian drilling: this `update' of ovarian wedge resection employs a unipolar coagulating current or puncture of the ovarian surface with a laser in four to ten places to a depth of 4±10 mm on each ovary. an analysis was conducted of the first 35 reports, mostly uncontrolled series, in which 82% of 947 patients ovulated following the operation and 63% conceived either spontaneously or after treatment with medications to which they had previously been resistant.