fosfluconazole fosfluconazole fosfluconazole (inn) is a water-soluble phosphate prodrug of fluconazole — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. fosfluconazoleclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationivatc codenonelegal statuslegal status in general: ℞ (prescription only) identifiers iupac name phosphonic acid cas number194798-83-9 npubchem cid214356chemspider185843 yunii3jij299ewhchemblchembl1908301 ncomptox dashboard (epa)dtxsid3048601 chemical and physical dataformulac13-h13-f2-n6-o4-pmolar mass386.256 g·mol−13d model (jsmol)interactive image smiles fc1ccc(c(f)c1)c(op(=o)(o)o)(cn2ncnc2)cn3ncnc3 inchi inchi=1s/c13h13f2n6o4p/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9h,4-5h2,(h2,22,23,24) ykey:ghjwnrrcriggio-uhfffaoysa-n y ny (what is this?) (verify) the phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).