dtp-hepb vaccine dtp-hepb vaccine dtp-hepb vaccine is a combination vaccine whose generic name is diphtheria and tetanus toxoids and whole-cell pertussis and hepatitis b (recombinant) vaccine (adsorbed) or dtp-hep b. it protects against the infectious diseases diphtheria, tetanus, pertussis, and hepatitis b. dtp-hepbcombination ofdtp vaccinevaccinehepatitis b vaccinevaccineclinical datatrade namestritanrix-hepbahfs/drugs.comuk drug informationroutes ofadministrationintramuscular injectionatc codej07ca05 (who) identifierscas number1012056-47-1 a branded formulation, tritanrix-hepb manufactured by glaxosmithkline, was granted marketing approval in the eu in 1996. marketing approval lapsed in 2014. a review conducted in 2012 concluded that there was insufficient evidence to determine differences in safety and efficacy between dtp-hepb vaccine and hib vaccine administered separately and pentavalent dtp-hepb-hib vaccine.