omodysplasia 2 omodysplasia 2 omodysplasia type 2 is a very rare genetic disorder characterised by abnormalities in the skull, long bones and genitourinary system. omodysplasia 2omodysplasia 2 is inherited in an autosomal dominant manner. clinical features these can be grouped under those evident in the skull/face, the long bones and the genitourinary system skull anteverted nostrils bifid nasal tip depressed nasal bridge fontal bossing long philtrum low set ears long bones short first metacarpal short humerus genitourinary genitourinary hypoplasia genetics this condition is inherited in an autosomal dominant fashion. mutations in the frizzled class receptor 2 (fzd2) gene have been associated with this condition. diagnosis differential diagnosis robinow syndrome treatment there is no currently known treatment for this condition. history this condition was first described by maroteaux et al in 1989.