inner enamel epithelium inner enamel epithelium the inner enamel epithelium, also known as the internal enamel epithelium, is a layer of columnar cells located on the rim nearest the dental papilla of the enamel organ in a developing tooth. this layer is first seen during the cap stage, in which these inner enamel epithelium cells are pre-ameloblast cells. these will differentiate into ameloblasts which are responsible for secretion of enamel during tooth development. inner enamel epitheliumthe cervical loop area: (1) dental follicle cells, (2) dental mesenchyme, (3) odontoblasts, (4) dentin, (5) stellate reticulum, (6) outer enamel epithelium, (7)inner enamel epithelium, (8) ameloblasts, (9) enamel.detailsidentifierslatinepithelium enameleum internumteenamel epithelium_by_e5.4.1.1.2.3.15 e5.4.1.1.2.3.15 anatomical terminology the location of the enamel organ where the outer and inner enamel epithelium join is called the cervical loop.