ab-001 ab-001 ab-001 (1-pentyl-3-(1-adamantoyl)indole) is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in ireland in 2010 and hungary and germany in 2011. it is unclear who ab-001 was originally developed by, but it is structurally related to compounds such as am-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for cb2 over cb1. the first published synthesis and pharmacological evaluation of ab-001 revealed that it acts as a full agonist at cb1 (ec50 = 35 nm) and cb2 receptors (ec50 = 48 nm). however, ab-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue apica, which possesses potent cannabimimetic activity at doses of 3 mg/kg. ab-001legal statuslegal status ca: schedule ii de: anlage ii (authorized trade only, not prescriptible) uk: class b identifiers iupac name 1-pentyl-3-(adamant-1-oyl)indole cas number1345973-49-0 npubchem cid57404070chemspider26286891 yuniih657dia015comptox dashboard (epa)dtxsid90158822 chemical and physical dataformulac24h31nomolar mass349.518 g·mol−13d model (jsmol)interactive image smiles cccccn1cc(c2c1cccc2)c(=o)c34cc5cc(c3)cc(c5)c4 inchi inchi=1s/c24h31no/c1-2-3-6-9-25-16-21(20-7-4-5-8-22(20)25)23(26)24-13-17-10-18(14-24)12-19(11-17)15-24/h4-5,7-8,16-19h,2-3,6,9-15h2,1h3 ykey:shwdycmmuppwqm-uhfffaoysa-n y ny (what is this?) (verify)