nufenoxole nufenoxole nufenoxole (sc-27166) is an antidiarrhoeal drug which acts as a peripherally selective opioid agonist, in a similar manner to loperamide and diphenoxylate. while it is able to activate μ-opioid receptors, it fails to cross the blood–brain barrier and so has a selective action against diarrhoea without producing analgesic effects. nufenoxoleidentifiers iupac name 2-octan-2-yl)-1,1-diphenylpropyl]-5-methyl-1,3,4-oxadiazole cas number57726-65-5pubchem cid42551chemspider38808unii39er7n857vkeggd05211chemblchembl3989894comptox dashboard (epa)dtxsid80206427 chemical and physical dataformulac25h29n3omolar mass387.527 g·mol−13d model (jsmol)interactive image smiles cc1=nn=c(o1)c(ccn2cc3ccc2cc3)(c4=cc=cc=c4)c5=cc=cc=c5 inchi inchi=1s/c25h29n3o/c1-19-26-27-24(29-19)25(21-8-4-2-5-9-21,22-10-6-3-7-11-22)16-17-28-18-20-12-14-23(28)15-13-20/h2-11,20,23h,12-18h2,1h3key:cvockgavxlcegm-uhfffaoysa-n