alphamethylthiofentanyl alphamethylthiofentanyl α-methyl-thiofentanyl is an opioid analgesic that is an analogue of fentanyl. alphamethylthiofentanylclinical dataother namesα-methyl-thiofentanylatc codenonelegal statuslegal status ca: schedule i de: anlage i (authorized scientific use only) uk: class a us: schedule i identifiers iupac name n-phenyl-n-propanamide cas number103963-66-2 ypubchem cid62309drugbankdb01470 ychemspider56104 yuniinf684lif79chemical and physical dataformulac21h28n2osmolar mass356.53 g·mol−13d model (jsmol)interactive image smiles o=c(n(c1ccccc1)c2ccn(cc2)c(cc3sccc3)c)cc inchi inchi=1s/c21h28n2os/c1-3-21(24)23(18-8-5-4-6-9-18)19-11-13-22(14-12-19)17(2)16-20-10-7-15-25-20/h4-10,15,17,19h,3,11-14,16h2,1-2h3 ykey:ypoxduyrrsuffg-uhfffaoysa-n y (verify) α-methyl-thiofentanyl was sold briefly on the black market in the early 1980s, before the introduction of the federal analog act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared. α-methyl-thiofentanyl has similar effects to fentanyl. side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. fentanyl analogs have killed hundreds of people throughout europe and the former soviet republics since the most recent resurgence in use began in estonia in the early 2000s, and novel derivatives continue to appear.