xywav xywav xywav, is a medication used to treat cataplexy or excessive daytime sleepiness (eds). it contains a mixture of oxybate salts, namely calcium oxybate, magnesium oxybate, potassium oxybate, and sodium oxybate. it is taken by mouth. not to be confused with xyrem. xywavcombination ofcalcium oxybatecns depressantmagnesium oxybatecns depressantpotassium oxybatecns depressantsodium oxybatecns depressantclinical datatrade namesxywavlicense data us dailymed: calcium_magnesium_potassium_and_sodium_oxybates routes ofadministrationby mouthatc codenonelegal statuslegal status us: schedule iii identifierskeggd12131 manufactured by the jazz pharmaceuticals company, it was approved for medical use in the united states in july 2020. medical uses xywav is indicated for the treatment of cataplexy in people aged seven years of age and older with narcolepsy. in august 2021, the u.s. food and drug administration (fda) approved xywav for the treatment of idiopathic hypersomnia. side effects breathing problems slowed breathing, trouble breathing, sleep apnea mental health problems confusion, hallucination, unusual or disturbing thoughts (abnormal thinking), anxiety, depression, suicidal thoughts or actions, increased tiredness, feelings of guilt or worthlessness, difficulty concentrating other sleepwalking society and culture legal status xywav was granted orphan drug designation in november 1994 by the u.s. food and drug administration (fda). the fda granted the approval of xywav to jazz pharmaceuticals plc in august 2021. other names in the testing phase of the drug, it was known as jzp-258