evolved form of the ne-alpha parasite. the parasite is capable of bonding to all b.o.w.s, from zombies to t-103 super soldiers. the parasite has an insectoid appearance, as opposed to the octopus-like form of its predecessor. however, it is prone to decapitating its host, rendering them blind and deaf. necroa virus plague. inc a playable zombie disease in the video game plague inc. it reanimates the dead and makes them into zombies, which the player can control to attack uninfected regions and anti-zombie task forces. symptoms include photophobia, psychosis, hypersalivation, polyphagia, cannibalism, and cytopathic reanimation, which makes zombies, although the player can choose what symptoms the disease can afflict on humans. neurax worm plague. inc a parasitic worm that burrows into the brain, which controls the host in everything they do by altering the production of various neurotransmitters. the player can make the worm kill everyone by suicide or, make the whole worship the worm thinking it is their god. symptoms include insanity, mania, memory loss, coma, adoration, devotion, and transcendence (which causes the humans to worship the worm as their eternal god by overdosing them with oxytocin and vasopressin). neuro-immuno deficiency syndrome (n.i.d.s.) sonic the hedgehog (series)sonic the hedgehog a rare, incurable, and fatal disease. shortly after prof. gerald robotnik refused g.u.n.'s request for him to discover the secret to immortality, his granddaughter maria contracted n.i.d.s., causing gerald to reconsider and begin project shadow. the cure was never found, despite gerald's success at creating the ultimate life form. maria later died of a gunshot wound during g.u.n.'s extermination of all involved in the project. nova 6 call of duty: black ops, call of duty: black ops iii, call of duty: black ops cold war appearing in call of duty: black ops, call of duty: black ops iii, and call of duty: black ops cold war, nova 6 was originally developed by nazi germany during the course of world war ii by friedrich steiner and intended for use in v-2 rockets targeted at major capital cities, such as washington, d.c. and moscow. it was later seized, refined, and used by the soviets, as a component of a grand soviet sleeper-cell plan by dragovich. preventing its release is one of the primary aims of alex mason and the cia in the 1960s. nova gas call of duty: black ops, call of duty: online a multiplayer weapon, this is a gas grenade that blurs vision, impairs movement and damages health over time. using a tactical mask makes one immune to it. porphyric hemophilia elder scrolls iii: morrowind, elder scrolls iv: oblivionthe elder scrolls iv: oblivion causes vampirism after an incubation period of three days. if the player is infected, they can go through a quest to cure the disease, however it is not necessary to be cured to complete the quest. oripathy arknights a widespread terminal and currently incurable disease contracted from contact with raw originium, a fictional mineral of the setting that is central to its industry and provides supernatural powers to those who can wield it. the only consistent symptoms of the disease is the formation of "ore lesions" on the skin, hardening, darkening, and growing, similar to a scab, before crystallizing into originium. it appears that this cutaneous originium formation is not a vector of infection, however, the infected will disintegrate into highly infectious and volatile originium dust upon death. person-to-person contamination is otherwise known to be very rare. oripathy is tracked using two markers: the density of originium crystals in the bloodstream, and the assimilation of originium particles by the body's cells. oripathy can cause a wide range of secondary symptoms ranging from real-world mental disorders, physical disorders, mutations, and disabilities, none of which are consistent across patients. oripathy is known to either hinder or facilitate the use of originium arts, supernatural abilities using originium as a catalyst, with no consistent cause between subjects. the infected are subject to various discriminations. pox of lechuck tales of monkey island the pox of lechuck (also named lechucken pox in the final episode) is a plague apparent in tales of monkey island that swept across the caribbean when guybrush stabbed lechuck with an enchanted voodoo sword at the rock of gelato. this caused lechuck to be stripped of his voodoo powers, releasing a pandemic that transformed many pirates into green-skinned, foul-mouthed monsters. it also spread to guybrush's hand, giving it a life of its own (even after being cut off by morgan leflay), as well as infecting his wife, elaine marley. the only known cure is la esponja grande, which guybrush embarks on a quest to find after speaking with the voodoo lady. progenitor virus resident evil series in the back-story of the series, the progenitor virus is the primary virus created by the umbrella corporation, a mutagen based on ebola, with some of its components extracted from strange flowers that bloom underground, seen in resident evil 5. successor viruses include the t-virus, the g-virus, and t-veronica virus. phazon madness metroid prime a virus transmitted by being in close proximity to phazon. the victim's mind is warped so they can no longer tell friend from foe, and exist only to destroy. phazon madness is extremely contagious, and it later develops into phazon fever, wherein the victim gains an obsessive compulsive disorder regarding phazon. infected victims can utilize phazon as a weapon and normally can only be killed by phazon itself. pink elephant disease zoo tycoon 2 a disease that causes elephants and mastodons to turn pink. it is spread through pink pursuit balls and cured with cotton candy. pokérus pokémon a virus that afflicts pokémon. though it is incurable, it has no negative effects, and is in fact helpful. pokémon with the condition gain double effort values in battle. the pokémon retains this ability even after its contagious period of 48 hours has passed. transmission is by proximity in a party, and the 48-hour "clock" is stopped by placing the pokémon into a pc. radical-6 zero escape: virtue's last reward radical-6 was a virus developed by the apocalyptic cult "free the soul" to destroy human civilization. a highly infectious virus, it causes the human brain to experience time at a 40% slower rate, and eventually drives its victims to suicide. the global pandemic eventually leads to a desperate (and hinted to be radical-6 induced) plan to detonate 18 anti-matter generators simultaneously, initiating a nuclear winter. roboenza mega man 10 a virus that affects humanoid robots, causing flu-like symptoms and eventually homicidal tendencies. created and subsequently cured by dr. wily. some theories hold that it is related to the evil energy from mega man 8 and the maverick virus from the mega man x series rotten world gas lollipop chainsaw a poisonous gas from the rotten world (hell) which leaks through interdimensional cracks caused by the necromancer swan when he cracks open a gate between earth and rotten world. this gas leaks through the cracks and kills everybody who inhales it within minutes, shortly reanimating them as psychotic zombies within a short while. it appears the gas is transmittable through bites, and therefore contagious. in hallucinations, the gas is also shown to affect animals. rustlung/lambency gears of war series a fictional underground substance known as imulsion was refined by the humans of sera and used as a limitless fuel source. however, unknown to the humans at the time, imulsion was a liquid fungal parasite that invades the host through spores in the imulsion fumes. miners of imulsion and their families became sick with imulsion-poisoning which would be called rustlung, a pneumonia-like condition that expels rust-colored phlegm. the government attempted to hide and resolve the issue by imprisoning the children sick with rustlung in the new hope research facility in order to cure the disease. however, the scientist in charge, dr. niles samson, went mad and genetically altered the children with the dna of indigenous creatures from underground, resulting in the creation of the locust horde, the main enemy species in the game. the government learned of these unethical experiments and dr. niles samson took them underground to continue his work. while underground, rustlung, later evolving into lambency in which the host becomes possessed by the imulsion, began to overrun the locust horde, forcing them to emerge on the surface and wage war against humanity in order to escape the lambent. all lambent inherit imuslion's qualities: golden glow in the dark and explosive properties. rustlung continued to infect the human population, especially during the war against the locust horde, in which the imulsion evaporated and polluted the surface with fumes due to bombing the underground. after the humans managed to flood the underground to kill both the locust and lambent, the seawater rose the imulsion into the soil and caused a pandemic to occur, infecting both locust and humans with lambency. both rustlung and lambency are destroyed, however, when professor adam fenix activates an imulsion countermeasure, which uses targeted levels of radiation to kill cells with imulsion. all imulsion was destroyed and organisms that were infected with imulsion were killed. sand plague pathologic a lethal, mysterious sickness affecting a small town. it manifests as deathly, skull-shaped clouds that follow the player, and can also be transmitted by touch and by rats. it produces immense pain in those who contract it; alleviating these symptoms in npcs increases the player character's reputation, but they themselves can get infected. the risk of infection can be reduced through protective clothing or certain medicines, while the disease itself can only be cured through "shmowders", concoctions created by children from old medicines. infected districts develop blotches of blood and scars on the ground and on the walls of the houses. scurge scurge: hive a parasite that can infect biological, technological, or coherent energy systems. it takes about one minute to overwhelm the special filters designed to ward off its infection. shadow plague plague. inc a playable, sentient disease tied to vampirism in the game plague inc. its symptoms in humans include increased strength, the urge to bite others, paler skin, hypersensitivity, dark cysts and higher pheromone secretion. it can be spread by one or more player-controlled vampires in addition to transmission among humans. "green flu" (previously unknown) left 4 dead,payday the heist: no mercy the green flu, commonly referred to simply as the infection, has caused most humans who come in contact with it to change into homicidal, zombie-like beings. anyone can catch it, but there are few out there who show no symptoms of the virus. they can, however, spread it to whoever comes in contact with them. these carriers seldom realize they are spreading the virus, leaving a path of destruction in their wake. the plague mass effect 2 the plague is a virus possibly created by the collectors which infects all species except humans and vorcha, the latter being resistant to any infection, and the former being immediately scapegoated for the spread of the plague and hunted down by local gangs. it causes horrible sores, a bad cough and coughing up blood, caused by rapid mutations to the respiratory systems. it was being spread through the ventilation system of the slums of omega by the vorcha under orders of the collectors but was stopped by shepard and doctor mordin solus, since omega has no authorities whatsoever and the affected area was simply sealed until everyone would die. the plague of undeath warcraft iii the plague is responsible for the entire undead race. it can re-animate dead creatures with a reasonable degree of sentience. however, the creature is usually dominated by the undead command structure, but they can escape from the tyranny of undeath. it also causes the soil beneath and around undead structures to change into a substance known as blight, which is poisonous to most plants. the rat plague dishonored the rat plague killed almost half of the population of the city of dunwall, the fictional city from the game dishonored. individuals with the rat plague can cure themselves via use of sokolov's health elixir. once blood comes from the nose or eyes there is no way to be cured. it is also known as the doom of pandyssia. rosalia virus trauma team a variation of viral hemorrhagic fever, capable of killing patients in days. the virus was originally found in the blood