edogestrone edogestrone edogestrone (inn, ban) (developmental code name ph-218), or edogesterone, also known as 17α-acetoxy-3,3-ethylenedioxy-6-methylpregn-5-en-20-one, is a steroidal progestin and antiandrogen of the 17α-hydroxyprogesterone group which was synthesized in 1964 but was never marketed. similarly to the structurally related steroid cyproterone acetate, edogestrone binds directly to the androgen receptor and antagonizes it, displacing androgens like testosterone from the receptor, though not as potently as cyproterone acetate. the drug has also been found to suppress androgen production, likely via progesterone receptor activation-mediated antigonadotropic activity. edogestroneclinical dataother namesedogesterone; ph-218; 17α-acetoxy-3,3-ethylenedioxy-6-methylpregn-5-en-20-onedrug classprogestogen; progestogen esteridentifiers iupac name phenanthrene]-17'-yl] acetate cas number809-01-8pubchem cid20055315chemspider92030unii9014ufk50cchemical and physical dataformulac26h38o5molar mass430.585 g·mol−13d model (jsmol)interactive image smiles cc1=c2cc3(ccc2(c4ccc5(c(c4c1)ccc5(c(=o)c)oc(=o)c)c)c)occo3 inchi inchi=1s/c26h38o5/c1-16-14-19-20(23(4)10-11-25(15-22(16)23)29-12-13-30-25)6-8-24(5)21(19)7-9-26(24,17(2)27)31-18(3)28/h19-21h,6-15h2,1-5h3/t19-,20+,21+,23-,24+,26+/m1/s1key:uoymghscinlobk-zkkylisvsa-n