coarse facial features coarse facial features coarse facial features (coarse facies) is a constellation of facial features that are present in many inborn errors of metabolism. coarse faciesa 16 year old with mucopolysaccharidosis showing coarse facial features.specialtymedical genetics features include: large, bulging head prominent scalp veins "saddle-like, flat bridged nose with broad, fleshy tip" large lips and tongue small, widely spaced and/or malformed teeth hypertrophic alveolar ridges and/or gums the head tends to be longer than normal from front to back, with a bulging forehead. this is because of the premature fusion of skull bones in the affected person. causes several conditions are associated with coarse facial features. acromegaly alpha-mannosidosis type ii aspartylglycosaminuria battaglia neri syndrome börjeson–forssman–lehmann syndrome chromosome 6q deletion syndrome coarse face - hypotonia - constipation congenital hypothyroidism dandy–walker malformation (with mental retardation basal ganglia disease and seizures) dyggve–melchior–clausen syndrome fucosidosis type 1 fucosidosis type ii gangliosidosis generalized gm1 (type 1) gangliosidosis gm1 (type 3) gm1 gangliosidosis goldberg syndrome hyde-forster-mccarthy-berry syndrome hyper ige hypomelanosis of ito i cell disease immunodeficiency due to defect in mapbp-interacting protein infantile sialic acid storage disorder job syndrome mannosidosis (alpha b lysosomal) mccune–albright syndrome mental retardation (x-linked - epilepsy - progressive joint contractures - typical face) mental retardation (x-linked raynaud type) miescher's syndrome morquio syndrome morquio syndrome type a morquio syndrome type b mps 3 c mps 3 d mucolipidosis iii mucopolysaccharidosis type 2 hunter syndrome- mild form mucopolysaccharidosis type 2 hunter syndrome- severe form mucopolysaccharidosis type 3 mucopolysaccharidosis type 6 mucopolysaccharidosis type 7 sly syndrome mucopolysaccharidosis type i hurler syndrome mucopolysaccharidosis type i hurler/scheie syndrome mucopolysaccharidosis type i scheie syndrome multiple endocrine abnormalities - adenylyl cyclase dysfunction multiple endocrine neoplasia type 2b neuraminidase deficiency (type ii juvenile form) nodulosis–arthropathy–osteolysis syndrome nonkeratan-sulfate-excreting morquio syndrome pituitary tumors (adult) sialidosis type ii (congenital) sialidosis type ii (infantile) sialuria syndrome simpson–golabi–behmel syndrome simpson–golabi–behmel syndrome - type 1 (sgbs1) skeletal dysplasia - coarse facies - mental retardation spondyloepimetaphyseal dysplasia (genevieve type) sulfatidosis juvenile (austin type) winchester syndrome