intravaginal administration intravaginal administration intravaginal administration is a route of administration where the substance is applied inside the vagina. pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration. administering medication vaginally using an applicator. administering medication vaginally without an applicator. formulation methods include vaginal tablets, vaginal cream, vaginal gel, vaginal suppository and vaginal ring. medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group of hormones including progesterone), and antibacterials and antifungals to treat bacterial vaginosis and yeast infections respectively. medicines may also be administered intravaginally as an alternative to oral route in the case of nausea or other digestive problems. it is a potential means of artificial insemination (referred to as intravaginal insemination or ivi), sometimes used at home without the presence of a professional. it is used as an administration method for contraception.