lodenafil lodenafil lodenafil (also known as hydroxyhomosildenafil, trade name helleva) is a drug belonging to a class of drugs called pde5 inhibitor, which many other erectile dysfunction drugs such as sildenafil, tadalafil, and vardenafil also belong to. like udenafil and avanafil it belongs to a new generation of pde5 inhibitors. lodenafilclinical datatrade nameshellevapregnancycategory not for use in women routes ofadministrationby mouthlegal statuslegal status in general: unscheduled identifiers iupac name 5-(2-ethoxy-5-phenyl)-1-methyl-3-propyl-1,4-dihydro-7h-pyrazolopyrimidin-7-one cas number398507-55-6 ypubchem cid4742795chemspider3929995 nunii29x84f932dcomptox dashboard (epa)dtxsid70192906 chemical and physical dataformulac23h32n6o5smolar mass504.61 g·mol−13d model (jsmol)interactive image smiles cccc1c2c(c(=o)nc(2)c3cc(ccc3occ)s(=o)(=o)n4ccn(cc4)cco)n(n1)c inchi inchi=1s/c23h32n6o5s/c1-4-6-18-20-21(27(3)26-18)23(31)25-22(24-20)17-15-16(7-8-19(17)34-5-2)35(32,33)29-11-9-28(10-12-29)13-14-30/h7-8,15,30h,4-6,9-14h2,1-3h3,(h,24,25,31) nkey:neykrkvlewkobi-uhfffaoysa-n n ny (what is this?) (verify) lodenafil carbonate lodenafil is formulated as a prodrug in the form of the carbonate ester dimer, lodenafil carbonate, which breaks down in the body to form two molecules of the active drug lodenafil. this formulation has higher oral bioavailability than the parent drug. it is manufactured by cristália produtos químicos e farmacêuticos in brazil and sold there under the brand-name helleva. it has undergone phase iii clinical trials, but is not yet approved for use in the united states by the u.s. food and drug administration.