salidroside salidroside salidroside (rhodioloside) is a glucoside of tyrosol found in the plant rhodiola rosea. it has been studied, along with rosavin, as one of the potential compounds responsible for the putative antidepressant and anxiolytic actions of this plant. salidroside may be more active than rosavin, even though many commercially marketed rhodiola rosea extracts are standardized for rosavin content rather than salidroside. salidroside names iupac name 2-(4-hydroxyphenyl)ethyl β-d-glucopyranoside systematic iupac name (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-oxane-3,4,5-triol other names salidrosiderhodiolosidetyrosol glucoside identifiers cas number 10338-51-9 y 3d model (jsmol) interactive image chembl chembl465208 n chemspider 140088 n echa infocard 100.224.258 pubchem cid 159278 unii m983h6n1s9 n comptox dashboard (epa) dtxsid4049034 inchi inchi=1s/c14h20o7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19h,5-7h2/t10-,11-,12+,13-,14-/m1/s1 nkey: ilrcgyurzsfmeg-rkqhyhrcsa-n ninchi=1/c14h20o7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19h,5-7h2/t10-,11-,12+,13-,14-/m1/s1key: ilrcgyurzsfmeg-rkqhyhrcbf smiles c1=cc(=cc=c1cco2((((o2)co)o)o)o)o properties chemical formula c14h20o7 molar mass 300.307 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references bioactivities salidroside was shown to improve glucose homeostasis and alleviate diabetic retinopathy in obese mice. the antioxidant, anti-inflammatory and neuroprotective effects of salidroside have also been reported. biosynthesis the salidroside biosynthetic pathway in rhodiola rosea was described in 2018. rhodiola contains a pyridoxal phosphate-dependent 4-hydroxyphenylacetaldehyde (4-hpaa) synthase that converts tyrosine to 4-hpaa, which is further reduced to tyrosol by 4-hpaa reductase. rhodiola contains a regio-selective tyrosol:udp-glucose 8-o-glucosyltransferase that glycosylates tyrosol to produce salidroside.