atrasentan atrasentan atrasentan is an experimental drug that is being studied for the treatment of various types of cancer, including non-small cell lung cancer. it is also being investigated as a therapy for diabetic kidney disease. atrasentanclinical dataatc codenoneidentifiers iupac name (2r,3r,4s)-4-(1,3-benzodioxol-5-yl)-1--2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid cas number173937-91-2 npubchem cid159594chemspider140321 yuniiv6d7vk2215chemblchembl9194 yecha infocard100.206.784 chemical and physical dataformulac29h38n2o6molar mass510.631 g·mol−13d model (jsmol)interactive image smiles o=c(o)4(c1ccc(oc)cc1)n(cc(=o)n(cccc)cccc)c4c2ccc3ococ3c2 inchi inchi=1s/c29h38n2o6/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20/h8-13,16,23,27-28h,4-7,14-15,17-19h2,1-3h3,(h,33,34)/t23-,27-,28+/m1/s1 ykey:motjmgvdpwrkoc-qpvynbjusa-n y ny (what is this?) (verify) atrasentan failed a phase 3 trial for prostate cancer in patients unresponsive to hormone therapy. a second trial confirmed this finding. it is an endothelin receptor antagonist selective for subtype a (eta). while other drugs of this type (sitaxentan, ambrisentan) exploit the vasoconstrictive properties of endothelin and are mainly used for the treatment of pulmonary arterial hypertension, atrasentan blocks endothelin induced cell proliferation. in april 2014, de zeeuw et al. showed that 0.75 mg and 1.25 mg of atrasentan reduced urinary albumin by 35 and 38% respectively with modest side effects. patients also had decreased home blood pressures (but no change in office readings) decrease total cholesterol and ldl. patients in the 1.25 mg dose group had increased weight gain which was presumably due to increased edema and had to withdraw from the study more than the placebo or 0.75 mg dose group. reductions in proteinuria have been associated with beneficial patient outcomes in diabetic kidney disease with other interventions but is not an accepted end-point by the fda. in 2013, sonar trial was initiated to determine if atrasentan reduces kidney failure in diabetic kidney disease.