tromantadine tromantadine tromantadine is an antiviral medicine used to treat herpes simplex virus. it is available in a topical gel under trade names viru-merz and viru-merz serol. its performance is similar to aciclovir. tromantadineclinical datatrade namesviru-merzahfs/drugs.cominternational drug namesroutes ofadministrationtopical (gel)atc coded06bb02 (who) j05ac03 (who)legal statuslegal status us: not fda-approved otc (ru) identifiers iupac name n-(1-adamantyl)-2-acetamide cas number53783-83-8 npubchem cid64377chemspider57947 yuniih191jfg8wakeggd07199 yniaid chemdb007760comptox dashboard (epa)dtxsid00202062 echa infocard100.053.409 chemical and physical dataformulac16h28n2o2molar mass280.412 g·mol−13d model (jsmol)interactive image smiles o=c(nc13cc2cc(cc(c1)c2)c3)coccn(c)c inchi inchi=1s/c16h28n2o2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14h,3-11h2,1-2h3,(h,17,19) ykey:uxqdwarbdddtkg-uhfffaoysa-n y ny (what is this?) (verify) like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane. mechanism tromantadine inhibits the early and late events in the virus replication cycle. it changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. it inhibits penetration of the virus. it also prevents uncoating of the virions. synthesis synthesis: patents: amide formation between amantadine and chloroacetyl chloride gives n-adamantan-1-yl-2-chloro-acetamide (1). ether formation with deanol (2) then completes the synthesis of tromantadine (3).