myospherulosis myospherulosis myospherulosis, also known as spherulocytosis, is a foreign body-type granulomatous reaction to lipid-containing material and blood. it may be seen in various settings including: fat necrosis. malignancy, e.g. renal cell carcinoma. placement of topical tetracycline in a petrolatum base into a surgical site. the resultant histopathologic pattern is most unusual and initially was mistakenly thought to represent a previously undescribed endosporulating fungus.