chromosome 1 chromosome 1 chromosome 1 is the designation for the largest human chromosome. humans have two copies of chromosome 1, as they do with all of the autosomes, which are the non-sex chromosomes. chromosome 1 spans about 249 million nucleotide base pairs, which are the basic units of information for dna. it represents about 8% of the total dna in human cells. chromosome 1human chromosome 1 pair after g-banding. one is from mother, one is from father.chromosome 1 pair in human male karyogram.featureslength (bp)248,387,328 bp(chm13)no. of genes1,961 (ccds)typeautosomecentromere positionmetacentric(123.4 mbp)complete gene listsccdsgene listhgncgene listuniprotgene listncbigene listexternal map viewersensemblchromosome 1entrezchromosome 1ncbichromosome 1ucscchromosome 1full dna sequencesrefseqnc_000001 (fasta) genbankcm000663 (fasta) it was the last completed chromosome, sequenced two decades after the beginning of the human genome project. genes number of genes the following are some of the gene count estimates of human chromosome 1. because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). among various projects, the collaborative consensus coding sequence project (ccds) takes an extremely conservative strategy. so ccds's gene number prediction represents a lower bound on the total number of human protein-coding genes. estimated by protein-coding genes non-coding rna genes pseudogenes source release date ccds1,961—— 2016-09-08 hgnc1,9937071,113 2017-05-12 ensembl2,0441,9241,223 2017-03-29 uniprot2,064—— 2018-02-28 ncbi2,0931,7901,426 2017-05-19 gene list the following is a partial list of genes on human chromosome 1. for complete list, see the link in the infobox on the right. c1orf112: encoding protein chromosome 1 open reading frame 112 c1orf127: encoding protein chromosome 1 open reading frame 127 c1orf27: encoding protein chromosome 1 open reading frame 27 c1orf38: encoding protein chromosome 1 open reading frame 38 ccdc181: encoding protein coiled-coil domain-containing protein 181 denn1b: hypothesized to be related to asthma fhad1: encoding protein forkhead-associated domain containing protein 1 loc100132287: uncharacterized protein lrriq3: encoding protein leucine-rich repeats and iq motif containing 3 shisa family member 4: encoding protein shisa family member 4 tinagl1: encoding protein tubulointerstitial nephritis antigen-like p-arm partial list of the genes located on p-arm (short arm) of human chromosome 1: aadacl3: arylacetamide deacetylase-like 3 aadacl4: arylacetamide deacetylase-like 4 acadm: acyl-coenzyme a dehydrogenase, c-4 to c-12 straight chain actg1p6: encoding protein actin, gamma 1 pseudogene 6 actl8: actin-like 8 adgrl2 (1p31.1): adhesion g protein-coupled receptor l2 adprhl2: poly(adp-ribose) glycohydrolase arh3 ampd2: encoding enzyme amp deaminase 2 arid1a (1p36) atxn7l2: ataxin 7-like 2 azin2: encoding enzyme antizyme inhibitor 2 (azi2) also known as arginine decarboxylase (adc) bcas2: breast carcinoma amplified sequence 2 bcl10 (1p22) lrif1: encoding protein ligand-dependent nuclear receptor-interacting factor 1 c1orf109: chromosome 1 open reading frame 109 c1orf162: encoding protein chromosome 1 open reading frame 162 c1orf194: encoding protein chromosome 1 open reading frame 194 czib: chromosome 1 open reading frame 123 cachd1 encoding protein cache domain containing 1 camk2n1: encoding protein calcium/calmodulin dependent protein kinase ii inhibitor 1 camta1 (1p36) casp9 (1p36) casz1 (1p36): castor zinc finger 1 ccdc17: encoding protein coiled-coil domain containing 17 ccdc18: encoding protein coiled-coil domain containing 18 cep85: encoding protein centrosomal protein 85 cfap74: encoding protein cilia and flagella associated protein 74 chd5 (1p36) clic4 (1p36) clspn (1p34) cmpk: ump-cmp kinase col16a1 (1p35) col11a1: collagen, type xi, alpha 1 cpt2: carnitine palmitoyltransferase ii cryz: crystallin zeta csde1: cold shock domain containing e1 cyp4b1 (1p33) cyr61 (1p22) dbt: dihydrolipoamide branched chain transacylase e2 dclre1b: dna cross-link repair 1b depdc1 encoding protein dep domain containing 1 diras3 (1p31): diras family, gtp-binding ras-like 3 disp3: encoding protein dispatched rnd transporter family member 3 dnase2b: encoding protein deoxyribonuclease 2 beta dph5: diphthine synthase dvl1 (1p36) eno1 (1p36) epha2 (1p36) eps15 (1p32) espn: espin (autosomal recessive deafness 36) evi5: ecotropic viral integration site 5 exo5: encoding protein exonuclease 5 extl1: exostosin like glycosyltransferase 1 extl2: exostosin like glycosyltransferase 2 fam46b: family with sequence similarity 46, member b fam46c: family with sequence similarity 46, member c fam76a: family with sequence similarity 76, member a fam87b: encoding protein family with sequence similarity 87 member b fbxo2: f-box protein 2 fnbp1l encoding protein formin-binding protein 1-like fpgt: fucose-1-phosphate guanylyltransferase fubp1 (1p31) gale: udp-galactose-4-epimerase gadd45a (1p31) gbp1 (1p22) gbp2: guanylate binding protein 2 gbp5 encoding protein guanylate binding protein 5 gbp6: encoding protein guanylate binding protein family member 6 gjb3: gap junction protein, beta 3, 31kda (connexin 31) glmn (1p22) gnl2: g protein nucleolar 2 gstm1 (1p13) guca2b: encoding protein guanylate cyclase activator 2b hdac1 (1p35) hes2: hes family bhlh transcription factor 2 hes3: hes family bhlh transcription factor 3 hmgcl: 3-hydroxymethyl-3-methylglutaryl-coenzyme a lyase (hydroxymethylglutaricaciduria) hao2 encoding protein hydroxyacid oxidase 2 hmgcs2: 3-hydroxy-3-methylglutaryl-coa synthase 2 hp1bp3: heterochromatin protein 1, binding protein 3 ifi6: interferon alpha-inducible protein 6 il22ra1 (1p36) ints11: integrator complex subunit 11 jak1 (1p31) jun (1p32) kank4: encoding protein kn motif and ankyrin repeat domains 4 kcnq4: potassium voltage-gated channel, kqt-like subfamily, member 4 kif1b: kinesin family member 1b l1td1: line-1 type transposase domain containing 1 lck (1p35) linc01137: encoding protein long intergenic non-protein coding rna 1137 lrrc39: leucine-rich repeat-containing protein 39 lrrc40: leucine-rich repeat-containing protein 40 lrrc41: leucine-rich repeat-containing protein 41 lrrc8d: leucine-rich repeat-containing protein 8d maco1: encoding protein transmembrane protein 57 man1a2: mannosyl-oligosaccharide 1,2-alpha-mannosidase ib map3k6: encoding protein mitogen-activated protein kinase kinase kinase 6 meaf6: myst/esa1 associated factor 6 mecr: trans-2-enoyl-coa reductase, mitochondrial mfap2: microfibrillar-associated protein 2 mib2 (1p36) mier1 (1p31) miga1: encoding protein mitoguardin 1 mfn2: mitofusin 2 mfsd2: major facilitator superfamily domain containing 2a mir6079: microrna 6079 mmel1: membrane metallo-endopeptidase-like 1 mtfr1l: mitochondrial fission regulator 1 like mthfr (1p36): 5,10-methylenetetrahydrofolate reductase (nadph) mul1: mitochondrial e3 ubiquitin protein ligase 1 mutyh (1p34): muty homolog (e. coli) nbpf3: neuroblastoma breakpoint family member 3 ndufa4p1: encoding protein nadh dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kda, pseudogene 1 ngf: nerve growth factor nol9: nucleolar protein 9 nras (1p13) notch2 (1p12) olfml3: olfactomedin-like 3 oma1: metalloendopeptidase oma1, mitochondrial ovgp1: oviductal glycoprotein 1 park7 (1p36): parkinson disease (autosomal recessive, early onset) 7 pink1: pten induced putative kinase 1 plod1: procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 pramef10: encoding protein prame family member 10 prmt6: protein arginine methyltransferase 6 prxl2b: encoding protein peroxiredoxin like 2b psrc1: proline/serine-rich coiled-coil protein 1 rad54l: rad54-like rap1a (1p13) rbm15 (1p13) rcc2: regulator of chromosome condensation 2 reg4 (1p12) rhbdl2: rhomboid like 2 rhoc (1p13) rims3: encoding protein regulating synaptic membrane exocytosis 3 rlf: rearranged l-myc fusion rnf11 (1p32) rnf19b: encoding protein ring finger protein 19b rnf220: ring finger protein 220 rpa2 (1p35) rspo1 (1p34) s100a1 (1q21) samd11: encoding protein sterile alpha motif domain containing 11 sdc3: syndecan-3 sdhb (1p36) sfpq (1p34): encoding protein splicing factor proline and glutamine rich sgip1: sh3 domain grb2-like protein 3-interaction protein 1 sh3bgrl3: sh3 domain-binding glutamic acid-rich-like protein 3 slc16a1 (1p13) slc2a1 glucose transporter 1 spsb1: spry domain-containing socs box protein 1 stil (1p33) sycp1: synaptonemal complex protein 1 szt2: seizure threshold 2 homolog tacstd2: tumor-associated calcium signal transducer 2 tal1 (1p33) tctex1d4: encoding protein tctex1 domain containing 4 tceb3: transcription elongation factor b polypeptide 3 tgfbr3 (1p22) thrap3 (1p34) tie1 (1p34) tm2d1: encoding protein tm2 domain containing 1 tmco2: encoding protein transmembrane and coiled-coil domains 2 tmco4: encoding protein transmembrane and coiled-coil domains 4 tmem48: encoding protein nucleoporin ndc1 tmem50a: transmembrane protein 50a tmem59: transmembrane protein 59 tmem69: transmembrane protein 69 tmem201 encoding protein transmembrane protein 201 tmem222: transmembrane protein 222 toe1: target of egr1 protein 1 trabd2b: encoding protein trab domain containing 2b trappc3: trafficking protein particle complex subunit 3 trit1: trna isopentenyltransferase, mitochondrial tshb: thyroid stimulating hormone, beta ttc39a: tetratricopeptide repeat 39a ubr4: e3 ubiquitin-protein ligase component n-recognin 4 urod: uroporphyrinogen decarboxylase (the gene for porphyria cutanea tarda) usp1 (1p31) usp48: ubiquitin carboxyl-terminal hydrolase 48 vav3 (1p13) vps13d: vacuolar protein sorting-associated protein 13d vtcn1 (1p13) wars2: tryptophanyl-trna synthetase, mitochondrial wdr77 (1p13) ybx1 (1p34) zcchc17: zinc finger cchc-type containing 17 zfp69: encoding protein zfp69 zinc finger protein zmym1 encoding protein zinc finger mym-type containing 1 znf436: zinc finger protein 436 znf684: encoding protein zinc finger protein 684 zyg11b encoding protein zyg-11 family member b, cell cycle regulator zzz3: zz-type zinc finger-containing protein 3 q-arm partial list of the genes located on q-arm (long arm) of human chromosome 1: abl2 (1q25) adipor1 (1q32) ahctf1: encoding protein elys akt3 (1q43-44) angptl1: angiopoietin-related protein 1 arhgef2 (1q22) arid4b: encoding protein at-rich interactive domain-containing protein 4b arv1 encoding protein arv1 homolog (s. cerevisiae) arnt (1q21) aspm (1q31): a brain size determinant atf3 (1q32) atp2b4 (1q32) bcl9 (1q21) catspere: encoding protein catsper channel auxiliary subunit epsilon c1orf21: chromosome 1 open reading frame 21 mmtap2 encoding protein multiple myeloma tumor-associated protein 2 tex35: tex35 c1orf74: chromosome 1 open reading frame 74 c2cd4d: c2 calcium-dependent domain-containing 4d cd5l: cd5 molecule like cenpl: centromere protein l cenpf (1q41) chtop: chromatin target of prmt1 cnih4: cornichon homolog 4 cnst: consortin creg1: cellular repressor of e1a stimulated genes 1 crp: c-reactive protein crtc2 (1q21) csrp1: cysteine and glycine rich protein 1 dcaf8: encoding protein ddb1 and cul4 associated factor 8 ddx59: dead-box helicase 59 del1q21: encoding protein chromosome 1q21.1 deletion syndrome dpt: dermatopontin disc2, long non-coding rna dnah14 encoding protein dynein, axonemal, heavy chain 14 dusp10 (1q41) dusp27: encoding protein dual specificity phosphatase 27 (putative) ecm1 (1q21) edem3: er degradation enhancing alpha-mannosidase like protein 3 egln1 (1q42) elf3: encoding protein e74 like ets transcription factor 3 enah (1q42) esrrg (1q41) fam129a: family with sequence similarity 129, member a fam163a: encoding protein neuroblastoma-derived secretory protein fam20b: fam20b, glycosaminoglycan xylosylkinase fam63a: family with sequence similarity 63, member a fam78b: family with sequence similarity 78, member b fam89a: encoding protein fam89a fbxo28: f-box protein 28 fcmr: fc fragment of igm receptor fcgr2b (1q23) fcgr2c: encoding protein fc fragment of igg receptor iic (gene/pseudogene) fh (1q43): fumarase flad1: encoding protein flavin adenine dinucleotide synthetase 1 flg-as1: encoding protein flg antisense rna 1 fmo3: flavin containing monooxygenase 3 fra1j encoding protein fragile site, 5-azacytidine type, common, fra(1)(q12) g0s2: encoding g0/g1 switch 2 gas5 (1q25) gba: glucosidase, beta; acid (includes glucosylceramidase) (gene for gaucher disease) gbap1: glucosylceramidase beta pseudogene 1 glc1a: gene for glaucoma gon4l: gon-4 like gpa33 (1q24) gpr37l1 g protein-coupled receptor 37 like 1 h3c13: encoding protein histone cluster 2 h3 family member d heatr1: heat repeat-containing protein 1 hfe2: hemochromatosis type 2 (juvenile) hist2h2ab: histone 2a type 2-b hist2h2bf: histone h2b type 2-f hist2h3ps2: histone cluster 2, h3, pseudogene 2 hist3h2a: histone h2a type 3 hist3h2bb: histone h2b type 3-b hrm2: hair, curly igsf8 (1q23) inava: innate immunity activator protein ints3: integrator complex subunit 3 irf2bp2: encoding protein interferon regulatory factor 2 binding protein 2 irf6: gene for connective tissue formation kcnh1 (1q32) kif14 (1q32) lefty1: left-right determination factor 1 lhx9 encoding protein lim homeobox 9 lmna: lamin a/c lmod1: encoding protein leiomodin 1 loc645166 encoding protein lymphocyte-specific protein 1 pseudogene lyplal1: lysophospholipase-like 1 mapkapk2 (1q32) mir194-1: microrna 194-1 mir5008: microrna 5008 mpc2: mitochondrial pyruvate carrier 2 mosc1: moco sulphurase c-terminal domain containing 1 mosc2: mosc domain-containing protein 2, mitochondrial mpz: myelin protein zero (charcot–marie–tooth neuropathy 1b) msto1: misato 1 mtr: 5-methyltetrahydrofolate-homocysteine methyltransferase nav1: neuron navigator 1 nbpf16: neuroblastoma breakpoint family, member 16 noc2l: nucleolar complex protein 2 homolog nucks1: nuclear ubiquitous casein and cyclin-dependent kinases substrate nvl: nuclear valosin-containing protein-like olfml2b: olfactomedin-like 2b optc: opticin otud7b: otu domain-containing protein 7b pacerr encoding protein ptgs2 antisense nfkb1 complex-mediated expression regulator rna pbx1 (1q23) pea15 (1q23) pgdb5: piggybac transposable element derived 5 pias3 (1q21) pi4kb: phosphatidylinositol 4-kinase beta pip5k1a (1q21): phosphatidylinositol-4-phosphate 5-kinase type-1 alpha pla2g4a (1q31) ppox: protoporphyrinogen oxidase prcc (1q23) prr9 encoding protein proline rich 9 psen2 (1q42): presenilin 2 (alzheimer disease 4) ptgs2 (1q31) ptpn14 (1q32-41) ptpn7 (1q32) rabif: rab interacting factor rassf5 (1q32) rgs2 (1q31) rn5s1@: rna, 5s ribosomal 1q42 cluster rps27 (1q21) scamp3: secretory carrier-associated membrane protein 3 sdhc (1q23) sele (1q24) sft2d2: encoding protein sft2 domain containing 2 shc1 (1q21) shcbp1l: encoding protein shc binding and spindle associated 1 like slc30a10: encoding protein solute carrier family 30 member 10 slc39a1 (1q21) slc50a1: solute carrier family 50 member 1 smcp: sperm mitochondrial-associated cysteine-rich protein smg7: nonsense mediated mrna decay factor smyd3 (1q44) spg23 sprr1a: cornifin-a sprr1b: cornifin-b sprr2a: small proline rich protein 2a sprtn: spartan tarbp1: tar (hiv-1) rna-binding protein 1 tbce: tubulin-specific chaperone e thbs3: thrombospondin 3 tmco1: transmembrane and coiled-coil domain-containing protein 1 tmem9: transmembrane protein 9 tmem63a: transmembrane protein 63a tmem81: transmembrane protein 81 tnfaip8l2: encoding tnf alpha induced protein 8 like 2 tnfsf18 (1q25) tnnt2: cardiac troponin t2 tor1aip1: