lipo-oxytocin-1 lipo-oxytocin-1 lipo-oxytocin-1 (lot-1) is a synthetic peptide and derivative of oxytocin that acts as an agonist of the oxytocin receptor. the lipidation strategy was applied to oxytocin to create a new peptide with improved pharmacokinetics. lot-1 consists of oxytocin conjugated with two palmitoyl groups. after adjusting for molecular weight (lot-1 is ~1.5x the weight of oxytocin), oxytocin and lot-1 are equipotent. in addition, lot-1 appears to have a significantly longer duration of effect relative to that of oxytocin. it has yet to be determined whether lot-1 possesses improved blood-brain-barrier permeability relative to oxytocin. lipo-oxytocin-1chemical and physical dataformulac75h126n12o14s2molar mass1484.02 g·mol−1