secondary systemic amyloidosis secondary systemic amyloidosis secondary systemic amyloidosis is a condition that involves the adrenal gland, liver, spleen, and kidney as a result of amyloid deposition due to a chronic disease such as behçet's disease, ulcerative colitis, etc.: 520 the condition is caused by an abornamility in plasma cell.s secondary systemic amyloidosismicrograph of liver amyloidosis, h&e stain