alpha 2-antiplasmin alpha 2-antiplasmin alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. this protein is encoded by the serpinf2 gene. fibrinolysis (simplified). blue arrows denote stimulation, and red arrows inhibition. serpinf2available structurespdbortholog search: pdbe rcsb list of pdb id codes2r9yidentifiersaliasesserpinf2, a2ap, aap, alpha-2-pi, api, pli, serpin family f member 2, alpha2apexternal idsomim: 613168 mgi: 107173 homologene: 719 genecards: serpinf2 gene location (human)chr.chromosome 17 (human)band17p13.3start1,742,836 bpend1,755,265 bpgene location (mouse)chr.chromosome 11 (mouse)band11|11 b5start75,322,558 bpend75,330,417 bprna expression patternbgeehumanmouse (ortholog)top expressed inright lobe of liverkidneyleft uterine tubeprostateupper lobe of left lungright lobe of thyroid glandmyometriumsubcutaneous adipose tissuepopliteal arterygastric mucosatop expressed inyolk sacliverproximal tubuleleft lobe of liverkidneygallbladderabdominal wallsexually immature organismureterstomachmore reference expression databiogpsmore reference expression datagene ontologymolecular function peptidase inhibitor activity protein homodimerization activity protease binding protein binding serine-type endopeptidase inhibitor activity endopeptidase inhibitor activity cellular component blood microparticle fibrinogen complex extracellular region cell surface extracellular exosome platelet alpha granule lumen extracellular space collagen-containing extracellular matrix biological process positive regulation of collagen biosynthetic process negative regulation of peptidase activity negative regulation of fibrinolysis negative regulation of plasminogen activation maintenance of blood vessel diameter homeostasis by renin-angiotensin blood vessel morphogenesis fibrinolysis collagen fibril organization platelet degranulation positive regulation of jnk cascade response to organic substance acute-phase response positive regulation of cell differentiation positive regulation of erk1 and erk2 cascade positive regulation of transforming growth factor beta production positive regulation of stress fiber assembly positive regulation of transcription by rna polymerase ii positive regulation of smooth muscle cell proliferation positive regulation of cell-cell adhesion mediated by cadherin negative regulation of endopeptidase activity sources:amigo / quickgoorthologsspecieshumanmouseentrez534518816ensemblensg00000167711ensg00000276838ensmusg00000038224uniprotp08697q61247refseq (mrna)nm_000934nm_001165920nm_001165921nm_008878refseq (protein)np_000925np_001159392np_001159393np_032904location (ucsc)chr 17: 1.74 – 1.76 mbchr 11: 75.32 – 75.33 mbpubmed searchwikidataview/edit humanview/edit mouse role in disease very few cases (<20) of a2ap deficiency have been described. as plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported. in liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. this is associated with an increase risk of bleeding in liver disease. interactions alpha 2-antiplasmin has been shown to interact with: neutrophil elastase and plasmin.