dmbmpp dmbmpp dmbmpp, or 2-(2,5-dimethoxy-4-bromobenzyl)-6-(2-methoxyphenyl)piperidine, is a 2-benzylpiperidine analog of the hallucinogenic n-benzylphenethylamine 25b-nbome and was discovered in 2011 by jose juncosa in the group of david e. nichols at purdue university. dmbmpp differs from 25b-nbome by incorporating the amine within a piperidine ring, making for a more rigid molecular structure than that of the open-chain 25b-nbome. the presence of the piperidine ring introduces two stereocenters, thus, four stereoisomers of this compound can be made. dmbmppclinical dataother namesjuncosamineatc codenoneidentifiers iupac name 2-(2,5-dimethoxy-4-bromobenzyl)-6-(2-methoxyphenyl)piperidine cas number1391499-52-7 npubchem cid72683323chemspider59718542chemical and physical dataformulac21h26brno3molar mass420.347 g·mol−13d model (jsmol)interactive image smiles coc(c=c(br)c(oc)=c1)=c1c2ccc(c3=c(oc)c=cc=c3)n2 inchi inchi=1s/c21h26brno3/c1-24-19-10-5-4-8-16(19)18-9-6-7-15(23-18)11-14-12-21(26-3)17(22)13-20(14)25-2/h4-5,8,10,12-13,15,18,23h,6-7,9,11h2,1-3h3/t15-,18-/m0/s1key:kmvglbonodptdy-yjbokzpzsa-n pharmacology the (s,s)-isomer ((2s,6s)-dmbmpp) is the most selective agonist for the human 5-ht2a receptor yet discovered, with a ki of 2.5 nm at the human 5-ht2a receptor and with 124-fold selectivity for 5-ht2a over the structurally similar 5-ht2c-receptor. together with 25cn-nboh, (2s,6s)-dmbmpp is the only known 5-ht2a agonist to exhibit this level of selectivity. ligandki ± sem (nm)ki ± sem (nm)ki ± sem (nm) ketanserin mesulerginefold selectivity h5-ht2ah5-ht2ch5-ht2c/h5-ht2a 2c-b6.0 ± 0.323.8 ± 2.69.5 25b-nbome0.19 ± 0.014.0 ± 0.421 (±)-dmbmpp5.3 ± 0.3520 ± 2298 (s,s)-(−)-dmbmpp2.5 ± 0.1310 ± 42124 (r,r)-(+)-dmbmpp2,100 ± 17128,600 ± 470027