jwh-019 jwh-019 jwh-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the cb1 and cb2 receptors. it is the n-hexyl homolog of the more common synthetic cannabinoid compound jwh-018. unlike the butyl homolog jwh-073, which is several times weaker than jwh-018, the hexyl homolog is only slightly less potent, although extending the chain one carbon longer to the heptyl homolog jwh-020 results in dramatic loss of activity. these results show that the optimum side chain length for cb1 binding in the naphthoylindole series is the five-carbon pentyl chain, shorter than in the classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds. this difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole compounds as compared to the classical cannabinoids, and may be useful in characterizing the active site of the cb1 and cb2 receptors. jwh-019legal statuslegal status ca: schedule ii de: anlage ii (authorized trade only, not prescriptible) uk: class b us: schedule i illegal in sweden, i-n (poland) identifiers iupac name 1-hexyl-3-(naphthalen-1-oyl)indole cas number209414-08-4 ychemspider24598813unii0z73828o4jcomptox dashboard (epa)dtxsid70175118 chemical and physical dataformulac25h25nomolar mass355.481 g·mol−13d model (jsmol)interactive image smiles c3cccc2c3cccc2c(=o)c1cn(cccccc)c4c1cccc4 inchi inchi=1s/c25h25no/c1-2-3-4-9-17-26-18-23(21-14-7-8-16-24(21)26)25(27)22-15-10-12-19-11-5-6-13-20(19)22/h5-8,10-16,18h,2-4,9,17h2,1h3key:paljpghwduhupo-uhfffaoysa-n (verify) legal status china as of october 2015 jwh-019 is a controlled substance in china. poland in poland, jwh-019 is i-n (poland). sweden jwh-019 is illegal in sweden. united kingdom jwh-019 is class b in the united kingdom. united states jwh-019 is a schedule i controlled substance, controlled federally in the united states.