6β-hydroxy-7α-thiomethylspironolactone 6β-hydroxy-7α-thiomethylspironolactone 6β-hydroxy-7α-thiomethylspironolactone (6β-oh-7α-tms) is a steroidal antimineralocorticoid of the spirolactone group and a major active metabolite of spironolactone. other important metabolites of spironolactone include 7α-thiospironolactone (7α-ts; sc-24813), 7α-thiomethylspironolactone (7α-tms; sc-26519), and canrenone (sc-9376). 6β-hydroxy-7α-thiomethylspironolactoneclinical dataother names6β-oh-7α-tms; 6β,17α-dihydroxy-7α-(methylthio)-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactonedrug classantimineralocorticoididentifiers iupac name (6s,7s,8r,10r,13s,14s,17r)-6-hydroxy-10,13-dimethyl-7-methylsulfanylspirophenanthrene-17,5'-oxolane]-2',3-dione cas number42219-60-3pubchem cid162502chemspider32820916unii4a93wo4z3gchemical and physical dataformulac23h32o4smolar mass404.57 g·mol−13d model (jsmol)interactive image smiles cs1(o)c2=cc(=o)cc2(c)3cc4(c)(cc45ccc(=o)o5)13 inchi inchi=1s/c23h32o4s/c1-21-8-4-13(24)12-16(21)19(26)20(28-3)18-14(21)5-9-22(2)15(18)6-10-23(22)11-7-17(25)27-23/h12,14-15,18-20,26h,4-11h2,1-3h3/t14-,15-,18+,19-,20-,21+,22-,23+/m0/s1key:nwlbswattsrbov-dfsnypbxsa-n spironolactone is a prodrug with a short terminal half-life of 1.4 hours. the active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-tms, 15.0 hours for 6β-oh-7α-tms, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. pharmacokinetics of 100 mg/day spironolactone and its metabolites compoundcmax (day 1)cmax (day 15)auc (day 15)t1/2 spironolactone72 ng/ml (173 nmol/l)80 ng/ml (192 nmol/l)231 ng•hour/ml (555 nmol•hour/l)1.4 hours canrenone155 ng/ml (455 nmol/l)181 ng/ml (532 nmol/l)2,173 ng•hour/ml (6,382 nmol•hour/l)16.5 hours 7α-tms359 ng/ml (924 nmol/l)391 ng/ml (1,006 nmol/l)2,804 ng•hour/ml (7,216 nmol•hour/l)13.8 hours 6β-oh-7α-tms101 ng/ml (250 nmol/l)125 ng/ml (309 nmol/l)1,727 ng•hour/ml (4,269 nmol•hour/l)15.0 hours sources: see template. 6β-hydroxytestosterone, which is analogous to 6β-oh-7α-tms, has been found to possess virtually no androgenicity.