clotiapine clotiapine clotiapine (entumine) is an atypical antipsychotic of the dibenzothiazepine chemical class. it was first introduced in a few european countries (namely, belgium, italy, spain and switzerland), argentina, taiwan and israel in 1970. clotiapineclinical datatrade namesetumina, etumine, entumin, etomine, entumineahfs/drugs.cominternational drug namesroutes ofadministrationoral, intravenous and intramuscularatc coden05ah06 (who) legal statuslegal status in general: ℞ (prescription only) identifiers iupac name 8-chloro-6-(4-methylpiperazin-1-yl)benzobenzothiazepine cas number2058-52-8 npubchem cid16351chemspider15510 yuniiz05hcy0x1tkeggd01597 ychebichebi:108591chemblchembl304902 ycomptox dashboard (epa)dtxsid5022851 echa infocard100.016.512 chemical and physical dataformulac18h18cln3smolar mass343.87 g·mol−13d model (jsmol)interactive image smiles clc2ccc1sc4c(/n=c(\c1c2)n3ccn(c)cc3)cccc4 inchi inchi=1s/c18h18cln3s/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12h,8-11h2,1h3 ykey:kaazgxdpunnefn-uhfffaoysa-n y ny (what is this?) (verify) some sources regard clotiapine as a typical antipsychotic rather than atypical due to its high incidence of extrapyramidal side effects compared to the atypicals like clozapine and quetiapine, to which it is structurally related. despite its profile of a relatively high incidence of extrapyramidal side effects it has demonstrated efficacy in treatment-resistant individuals with schizophrenia according to a number of psychiatrists with clinical experience with it, some weak clinical evidence supports this view too. a systematic review compared clotiapine with other antipsychotic drugs: clotiapine compared to other antipsychotic drugs for acute psychotic illnesses summary there was no evidence to support or refute the use of clotiapine in preference to other antipsychotic drug treatments for management of people with acute psychotic illness. outcome findings in words findings in numbers quality of evidence general clinical impression no significant improvementthere is no clear difference between people given clotiapine and those receiving other antipsychotic drugs for acute psychotic illnesses. these findings are based on data of low quality. rr 0.88 (0.39 to 1.98)low not well enough to be dischargedclotiapine is not clearly different to other antipsychotic drugs for this outcome - for people who are acutely unwell. these findings are based on data of low quality. rr 1.04 (0.93 to 1.16)low adverse effects movement disorders - use of antiparkinsonian medicationclotiapine may reduce the use of antiparkinsonian drugs - implying that clotiapine causes less of this effect, but, at present it is not possible to be confident about the difference between the two treatments and data supporting this finding are very limited. rr 0.43 (0.05 to 3.53)very low seizureclotiapine may increase the risk of fits, but, the difference between the two treatments is not clear. this finding is based on data of low quality. rr 3.67 (0.16 to 84.66)low satisfaction with care leaving the study early - any reasonthere is no clear difference between people given clotiapine and those receiving other antipsychotics for acute psychotic illnesses. these findings are based on data of low quality. rr 2.09 (0.81 to 5.42)low no study reported any data on outcomes as sedation and information relating to behavioral outcomes such as tranquillisation.clotiapine increases very fast weight, like approximately in 6 or 7 days of the start, so it is convenient to speak with your doctor it this happens.