14-methoxymetopon 14-methoxymetopon 14-methoxymetopon is an experimental opioid drug developed by a team led by professor helmut schmidhammer at the university of insbruck in the mid 1990s. it is a derivative of metopon in which a methoxy group has been inserted at the 14-position. it is a highly potent analgesic drug that is around 500 times stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. it binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs. this produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other effects such as constipation and respiratory depression which is believed to involve interaction with the κ-opioid receptor 14-methoxymetoponclinical dataother names14-methoxymetoponidentifiers iupac name 3-hydroxy-14-methoxy-5,17-dimethyl-7,8-dihydro-4,5α-epoxy-morphinan-6-one cas number131575-03-6 npubchem cid5486940chemspider4589140 ychemblchembl326684 ycomptox dashboard (epa)dtxsid50927273 chemical and physical dataformulac19h23no4molar mass329.396 g·mol−13d model (jsmol)interactive image smiles c12c(=o)cc3(14ccn(3cc5=c4c(=c(c=c5)o)o2)c)oc inchi inchi=1s/c19h23no4/c1-17-14(22)6-7-19(23-3)13-10-11-4-5-12(21)16(24-17)15(11)18(17,19)8-9-20(13)2/h4-5,13,21h,6-10h2,1-3h3/t13-,17+,18+,19-/m1/s1 ykey:denicfhulardrg-wezqjltasa-n y ny (what is this?) (verify)