pregnenolone succinate pregnenolone succinate pregnenolone succinate (usan; brand names panzalone, formula 405; also known as pregnenolone hemisuccinate or pregn-5-en-3β-ol-20-one 3β-(hydrogen succinate)) is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and anti-inflammatory drug and has been patented and marketed as a topical medication in the form of a cream for the treatment of allergic, pruritic, and inflammatory dermatitis. it has also been described as a non-hormonal sterol, having neurosteroid activity, and forming a progesterone analogue via dehydrogenation. pregnenolone succinateclinical datatrade namespanzalone, formula 405other namespregnenolone hemisuccinate; pregn-5-en-3β-ol-20-one 3β-(hydrogen succinate)routes ofadministrationtopicalidentifiers iupac name 4-phenanthren-3-yl]oxy]-4-oxobutanoic acid cas number4598-67-8pubchem cid10070529chemspider8246069unii6ln4w6jjk6keggd05604chemblchembl2105373comptox dashboard (epa)dtxsid40196673 echa infocard100.022.728 chemical and physical dataformulac25h36o5molar mass416.558 g·mol−13d model (jsmol)interactive image smiles cc(=o)1cc21(cc32cc=c43(cc(c4)oc(=o)ccc(=o)o)c)c inchi inchi=1s/c25h36o5/c1-15(26)19-6-7-20-18-5-4-16-14-17(30-23(29)9-8-22(27)28)10-12-24(16,2)21(18)11-13-25(19,20)3/h4,17-21h,5-14h2,1-3h3,(h,27,28)/t17-,18-,19+,20-,21-,24-,25+/m0/s1key:ozzayjqnmkmusd-dmisragpsa-n in addition to its glucocorticoid effects, pregnenolone succinate has been found to act as a negative allosteric modulator of the gabaa receptor and a positive allosteric modulator of the nmda receptor similarly to pregnenolone sulfate.