motolimod motolimod motolimod (vtx-2337) is a drug which acts as a potent and selective agonist of toll-like receptor 8 (tlr8), a receptor involved in the regulation of the immune system. it is used to stimulate the immune system, and has potential application as an adjuvant therapy in cancer chemotherapy, although clinical trials have shown only modest benefits. it also worsens neuropathic pain in animal models and has been used to research the potential of targeting tlr8 in some kinds of chronic pain syndromes. motolimodidentifiers iupac name 2-amino-n,n-dipropyl-8--3h-1-benzazepine-4-carboxamide cas number926927-61-9pubchem cid16049404drugbankdb12303chemspider13177800uniiwp6py72zh3keggd10716chemblchembl3301618comptox dashboard (epa)dtxsid10239107 chemical and physical dataformulac28h34n4o2molar mass458.606 g·mol−13d model (jsmol)interactive image smiles cccn(ccc)c(=o)c1=cc2=c(c=c(c=c2)c3=cc=c(c=c3)c(=o)n4cccc4)n=c(c1)n inchi inchi=1s/c28h34n4o2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-18h,3-6,13-16,19h2,1-2h3,(h2,29,30)key:qspoqcxmgpdihi-uhfffaoysa-n