ksc-12-192 ksc-12-192 ksc-12-192 is a drug that is used in scientific research to study the κ-opioid receptor, where it acts as a biased agonist. ksc-12-192clinical dataother names"probe 1.1"atc codenoneidentifiers iupac name 2-methylsulfanyl]-1,2,4-triazol-3-yl]pyridine pubchem cid46245518chemspider58145205chemblchembl4458783chemical and physical dataformulac21h17f3n4osmolar mass430.45 g·mol−13d model (jsmol)interactive image smiles cc1=c(c=c(c=c1)csc2=nn=c(n2cc3=cc=co3)c4=cc=cc=n4)c(f)(f)f inchi inchi=1s/c21h17f3n4os/c1-14-7-8-15(11-17(14)21(22,23)24)13-30-20-27-26-19(18-6-2-3-9-25-18)28(20)12-16-5-4-10-29-16/h2-11h,12-13h2,1h3key:oqjgzgayscwfck-uhfffaoysa-n ksc-12-192 preferentially activates g-protein coupling over β-arrestin 2 recruitment in vitro, an intrinsic activity shared with many other kor ligands developed to separate kor-mediated analgesia from accompanying dysphoria. compared with most of the known kor g-protein biased agonists, ksc-12-192 and its parent compound ml138 do not exhibit stereoisomerism. out of a range of tested compounds with the same substituted triazole scaffold (see table), ksc-12-192 had the highest reported in vitro potency as a human kor agonist (ec50 = 31nm). scaffoldidentifiers x r1 r2 r3 ksc-12-192probe 1.1 ohch3cf3 ml138ksc-5-240probe 1 ohclcl ksc-12-193probe 1.3 shch3cf3 ksc-5-247g shclcl ksc-12-238-b5probe 1.4 och3ch3cf3 ksc-12-238-b4 och3clcl