adenosquamous carcinoma adenosquamous carcinoma adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells. it has been associated with more aggressive characteristics when compared to adenocarcinoma in certain cancers. it is responsible for 1% to 4% of exocrine forms of pancreas cancer. adenosquamous carcinomamicrograph of an adenosquamous carcinoma of the lung. the adeno- or glandular component is on the left of the image and the squamous component on the right of the image. h&e stain.specialtyoncology diagnosis micrograph of adenosquamous carcinoma of the pancreas. light microscopy shows a combination of gland-like cells and squamous epithelial cells. on immunohistochemistry, it is typically positive for ck5/6, ck7 and p63, and negative for ck20, p16 and p53. on genetic testing, kras and p53 are typically altered.