clopenthixol clopenthixol clopenthixol (sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. it was introduced by lundbeck in 1961. clopenthixolclinical dataroutes ofadministrationoralatc coden05af02 (who) identifiers iupac name (e,z)-2-piperazin-1-yl]ethanol cas number982-24-1 ye: 53772-84-2 ypubchem cid12454chemspider11945 nunii0a432d932ae: fle878a8zi ykeggd02613 nchemblchembl53904 ncomptox dashboard (epa)dtxsid9048223 echa infocard100.012.333 chemical and physical dataformulac22h25cln2osmolar mass400.97 g·mol−13d model (jsmol)interactive image smiles clc2cc1c(c3c(sc1cc2)cccc3)=cccn4ccn(cco)cc4 ny (what is this?) (verify) clopenthixol is a mixture of cis and trans isomers. zuclopenthixol, the pure cis isomer, was later introduced by lundbeck in 1962, and has been much more widely used. both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison. clopenthixol is not approved for use in the united states. pharmacokinetics of long-acting injectable antipsychotics medicationbrand nameclassvehicledosagetmaxt1/2 singlet1/2 multiplelogpcref aripiprazole lauroxilaristadaatypicalwatera441–1064 mg/4–8 weeks24–35 days ?54–57 days7.9–10.0 aripiprazole monohydrateabilify maintenaatypicalwatera300–400 mg/4 weeks7 days ?30–47 days4.9–5.2 bromperidol decanoateimpromen decanoastypicalsesame oil40–300 mg/4 weeks3–9 days ?21–25 days7.9 clopentixol decanoatesordinol depottypicalviscoleob50–600 mg/1–4 weeks4–7 days ?19 days9.0 flupentixol decanoatedepixoltypicalviscoleob10–200 mg/2–4 weeks4–10 days8 days17 days7.2–9.2 fluphenazine decanoateprolixin decanoatetypicalsesame oil12.5–100 mg/2–5 weeks1–2 days1–10 days14–100 days7.2–9.0 fluphenazine enanthateprolixin enanthatetypicalsesame oil12.5–100 mg/1–4 weeks2–3 days4 days ?6.4–7.4 fluspirileneimap, redeptintypicalwatera2–12 mg/1 week1–8 days7 days ?5.2–5.8 haloperidol decanoatehaldol decanoatetypicalsesame oil20–400 mg/2–4 weeks3–9 days18–21 days7.2–7.9 olanzapine pamoatezyprexa relprevvatypicalwatera150–405 mg/2–4 weeks7 days ?30 days– oxyprothepin decanoatemeclopintypical ? ? ? ? ?8.5–8.7 paliperidone palmitateinvega sustennaatypicalwatera39–819 mg/4–12 weeks13–33 days25–139 days ?8.1–10.1 perphenazine decanoatetrilafon dekanoattypicalsesame oil50–200 mg/2–4 weeks ? ?27 days8.9 perphenazine enanthatetrilafon enanthatetypicalsesame oil25–200 mg/2 weeks2–3 days ?4–7 days6.4–7.2 pipotiazine palmitatepiportil longumtypicalviscoleob25–400 mg/4 weeks9–10 days ?14–21 days8.5–11.6 pipotiazine undecylenatepiportil mediumtypicalsesame oil100–200 mg/2 weeks ? ? ?8.4 risperidonerisperdal constaatypicalmicrospheres12.5–75 mg/2 weeks21 days ?3–6 days– zuclopentixol acetateclopixol acuphasetypicalviscoleob50–200 mg/1–3 days1–2 days1–2 days4.7–4.9 zuclopentixol decanoateclopixol depottypicalviscoleob50–800 mg/2–4 weeks4–9 days ?11–21 days7.5–9.0 note: all by intramuscular injection. footnotes: a = microcrystalline or nanocrystalline aqueous suspension. b = low-viscosity vegetable oil (specifically fractionated coconut oil with medium-chain triglycerides). c = predicted, from pubchem and drugbank. sources: main: see template.