prednylidene prednylidene prednylidene is a glucocorticoid for systemic use. prednylideneclinical dataother names(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-16-methylidene-6,7,8,9,11,12,14,15-octahydrocyclopentaphenanthren-3-oneatc codeh02ab11 (who) identifiers iupac name (11β)-11,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione cas number599-33-7 npubchem cid20055008chemspider16735979 yuniiif8pqp966ucomptox dashboard (epa)dtxsid50208610 echa infocard100.009.060 chemical and physical dataformulac22h28o5molar mass372.455 g·mol−13d model (jsmol)interactive image smiles occ(=o)2(o)c(=c)c34cc\c1=c\c(=o)\c=c/1(c)4(o)c23c inchi inchi=1s/c22h28o5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,15-17,19,23,25,27h,1,4-5,8,10-11h2,2-3h3/t15-,16-,17-,19+,20-,21-,22-/m0/s1 ykey:wsvomandjdyyey-cwnvbekcsa-n y ny (what is this?) (verify) substitution at position 16 also leads to more potent corticosteroids. the additional steric bulk introduced by such substituents adjacent to the dihydroxyacetone side chain also protects that moiety against metabolic degradation.