luminespib luminespib luminespib (inn, previously known as nvp-auy922) is an experimental drug candidate for the treatment of cancer. it was discovered through a collaboration between the institute of cancer research and the pharmaceutical company vernalis and licensed to novartis. from 2011 to 2014 it was in phase ii clinical trials. chemically it is a resorcinylic isoxazole amide luminespib names preferred iupac name 5--n-ethyl-4--1,2-oxazole-3-carboxamide other names nvp-auy-922; auy922; ver-52296 identifiers cas number 747412-49-3 n 3d model (jsmol) interactive image chebi chebi:83656 y chembl chembl252164 y chemspider 21377936 y drugbank db11881 kegg d10646 y pubchem cid 135539077 unii c6v1dar5eb inchi inchi=1s/c26h31n3o5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31h,4,9-12,15h2,1-3h3,(h,27,32) ykey: ndazatdqfdpqbd-uhfffaoysa-n yinchi=1s/c26h31n3o5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31h,4,9-12,15h2,1-3h3,(h,27,32) smiles cc(c)c1cc(c(o)cc1o)c2onc(c(=o)ncc)c2c3ccc(cc3)cn4ccocc4 properties chemical formula c26h31n3o5 molar mass 465.550 g·mol−1 appearance colorless solid except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references luminespib is an inhibitor of heat shock protein 90 (hsp90), which is a chaperone protein that plays a role in the modification of a variety of proteins that have been implicated in oncogenesis. luminespib has shown promising activity in preclinical testing against several different tumor types. a related compound, nvp-hsp990, was abandoned by novartis in 2012 after it failed to show efficacy in an early clinical trial.