fluocinolone acetonide fluocinolone acetonide fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. it is a synthetic hydrocortisone derivative. the fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. it was first synthesized in 1959 in the research department of syntex laboratories s.a. mexico city. preparations containing it were first marketed under the name synalar. a typical dosage strength used in dermatology is 0.01–0.025%. one such cream is sold under the brand name flucort-n and includes the antibiotic neomycin. fluocinolone acetonideclinical datatrade namessynalar, iluvien, othersahfs/drugs.commonographmonographpregnancycategory au: a routes ofadministrationtopical, ophthalmic intravitreal injectionatc codec05aa10 (who) d07ac04 (who) s01ba15 (who) s02ba08 (who)legal statuslegal status au: s4 (prescription only) ca: ℞-only uk: pom (prescription only) us: ℞-only in general: ℞ (prescription only) pharmacokinetic datametabolismliver, cyp3a4-mediatedelimination half-life1.3 to 1.7 hoursidentifiers iupac name (1s,2s,4r,8s,9s,11s,12r,13s,19s)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacycloicosa-14,17-dien-16-one cas number67-73-2 ypubchem cid6215iuphar/bps7077drugbankdb00591 ychemspider5980 yunii0cd5fd6s2mkeggd01825 ychebichebi:31623 nchemblchembl989 ycomptox dashboard (epa)dtxsid0040674 echa infocard100.000.607 chemical and physical dataformulac24h30f2o6molar mass452.495 g·mol−13d model (jsmol)interactive image smiles o=c\1\c=c5/(/c=c/1)(c)2(f)(3(c2o)(4(oc(o4c3)(c)c)c(=o)co)c)c5f inchi inchi=1s/c24h30f2o6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29h,8-11h2,1-4h3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 ykey:feblzlntkcefit-vsxgltovsa-n y ny (what is this?) (verify) fluocinolone acetonide was also found to strongly potentiate tgf-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type ii by more than 100 fold compared to the widely used dexamethasone. fluocinolone acetonide intravitreal implants have been used to treat non-infectious uveitis. a systematic review could not determine whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis. a fluocinolone acetonide intravitreal implant with the brand name iluvien is sold by biopharmaceutical company alimera sciences to treat diabetic macular edema (dme). it was approved for medical use in 1961. classification fluocinolone is a group v (0.025%) or group vi (0.01%) corticosteroid under us classification.