scaper scaper scaper (s-phase cyclina associated protein residing in the endoplasmic reticulum) is a gene located on the long arm of chromosome 15 (15q24.3). it was first identified in 2007. scaperidentifiersaliasesscaper, znf291, zfp291, mstp063, s-phase cyclin a associated protein in the er, iddrpexternal idsomim: 611611 mgi: 1925976 homologene: 32488 genecards: scaper gene location (human)chr.chromosome 15 (human)band15q24.3start76,347,904 bpend76,905,444 bpgene location (mouse)chr.chromosome 9 (mouse)band9|9 bstart55,457,163 bpend55,845,403 bprna expression patternbgeehumanmouse (ortholog)top expressed insural nerveachilles tendonganglionic eminencehypothalamusanterior pituitarygastrocnemius musclecerebellar hemispherebrodmann area 9cingulate gyrusprefrontal cortextop expressed inarcuate nucleusotolith organutriclemedian eminencesecondary oocyteparaventricular nucleus of hypothalamuspiriform cortexventromedial nucleussupraoptic nucleushabenulamore reference expression databiogpsn/aorthologsspecieshumanmouseentrez49855244891ensemblensg00000140386244891uniprotq9by12n/arefseq (mrna)nm_001145923nm_020843nm_001353009nm_001353010nm_001353011nm_001353012nm_001081341nm_175536nm_001357652nm_001357653refseq (protein)np_001139395np_065894np_001339938np_001339939np_001339940np_001339941n/alocation (ucsc)chr 15: 76.35 – 76.91 mbchr 9: 55.46 – 55.85 mbpubmed searchwikidataview/edit humanview/edit mouse gene this gene lies on the crick strand and has 30 exons. protein the gene encodes a 1399-amino acid protein with a predicted weight of 158 kilodaltons. it has a c2h2-type zinc finger motif, a putative transmembrane domain, an er retrieval signal at the c terminus, 4 coiled-coil domains, 6 potential rxl motifs and 6 consensus cdk phosphorylation sites. biochemistry the encoded protein is found in the nucleus and endoplasmic reticulum. it is found in all tissues tested. it appears to have a role in the cell cycle. clinical significance mutations in this gene have been associated with intellectual disability and retinitis pigmentosa.