ceftezole ceftezole ceftezole (or ceftezol) is a semisynthetic first-generation cephalosporin antibiotic. ceftezoleclinical dataatc codej01db12 (who) identifiers iupac name (6r,7r)-8-oxo-7--3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclooct-2-ene-2-carboxylic acid cas number26973-24-0pubchem cid65755chemspider59178 yunii2z86syp11wkeggd07656 ychemblchembl1697829comptox dashboard (epa)dtxsid0022771 echa infocard100.113.941 chemical and physical dataformulac13h12n8o4s3molar mass440.47 g·mol−13d model (jsmol)interactive image smiles o=c2n1/c(=c(\cs12nc(=o)cn3nnnc3)csc4nncs4)c(=o)o inchi inchi=1s/c13h12n8o4s3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11h,1-3h2,(h,16,22)(h,24,25)/t8-,11-/m1/s1 ykey:dzmvcvmfetwniu-ldymziiasa-n y ceftezole binds to and inactivates penicillin-binding proteins (pbps) located on the inner membrane of the bacterial cell wall. pbps are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. inactivation of pbps interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. this results in the weakening of the bacterial cell wall and causes cell lysis. ceftezole is having (1,3,4-thiadiazol-2-ylsulfanyl)methyl and [2-(1h-tetrazol-1-yl)acetamido side groups located at positions 3 and 7 respectively. it is a cephalosporin and a member of thiadiazoles.