implantable cardioverter-defibrillator implantable cardioverter-defibrillator an implantable cardioverter-defibrillator (icd) or automated implantable cardioverter defibrillator (aicd) is a device implantable inside the body, able to perform defibrillation, and depending on the type, cardioversion and pacing of the heart. the icd is the first-line treatment and prophylactic therapy for patients at risk for sudden cardiac death due to ventricular fibrillation and ventricular tachycardia. implantable cardioverter-defibrillatora guidant corporation icd deviceicd-937.94-37.97meshd017147medlineplus007370emedicine1971119 illustration of implantable cardioverter defibrillator (icd) "aicd" was trademarked by the boston scientific corporation, so the more generic "icd" is preferred terminology. a single chamber icd with its right ventricular lead connected into the header; note, starting from the end of the lead, the tip and adjacent first ring, used to sense the cardiac electrical activity and stimulate the right ventricle, the coil and the two rings for atrial sensing. current device batteries last about six to ten years; with advances in technology (batteries with more capacity or potentially rechargeable batteries) it may be possible to increase this well past ten years. the lead (the electrical cable connecting the device to the heart) has a much longer average longevity but can incur various types of malfunction, specifically insulation failure or fracture of the conductor, and require replacement. a normal chest x-ray after placement of an icd, showing the icd generator in the upper left chest and the icd lead in the right ventricle of the heart. note the 2 opaque coils along the icd lead. the process of implantation of an icd system is similar to implantation of a pacemaker. in fact, icds are composed of an icd generator and of wires. the first component or generator contains a computer chip or circuitry with ram (memory), programmable software, a capacitor and a battery; this is implanted typically under the skin in the left upper chest. the second part of the system is an electrode wire or wires that, similar to pacemakers, are connected to the generator and passed through a vein to the right chambers of the heart. the lead usually lodges in the apex or septum of the right ventricle. just like pacemakers, icds can have a single wire or lead in the heart (in the right ventricle, single chamber icd), two leads (in the right atrium and right ventricle, dual chamber icd) or three leads (biventricular icd, one in the right atrium, one in the right ventricle and one on the outer wall of the left ventricle). the difference between pacemakers and icds is that pacemakers are also available as temporary units and are generally designed to correct slow heart rates, i.e. bradycardia, while icds are often permanent safeguards against sudden life-threatening arrhythmias. s-icd lead and generator position recent developments include the subcutaneous icd (s-icd) which is placed entirely under the skin, leaving the vessels and heart untouched. indications implantation of icd is meant to prevent sudden cardiac death and is indicated under various conditions. two broad but distinct categories are primary and secondary prevention. primary prevention refers to patients who have not suffered a life-threatening arrhythmia episode. secondary prevention has the strongest evidence for benefit and it refers to survivors of cardiac arrest secondary to ventricular fibrillation or hemodynamically unstable sustained ventricular tachycardia after reversible causes are excluded. similarly, icd use in primary prevention is to prevent cardiac death in patients who are at risk for sustained ventricular tachycardia or ventricular fibrillation. this population accounts for the bulk of all icd implants. there are a multitude of guideline indications for icd use in primary preventions with varying degree of supporting evidence. periodically, both the american college of cardiology (acc)/american heart association (aha) and european society of cardiology provide an update to this guideline. some of the class i indications are as follows: with lvef ≤ 35% due to prior myocardial infarction (mi) who are at least 40 days post-mi and are in nyha functional class ii or iii with lv dysfunction due to prior mi who are at least 40 days post-mi, have an lvef ≤ 30%, and are in nyha functional class i with nonischemic dcm who have an lvef ≤ 35% and who are in nyha functional class ii or iii with nonsustained vt due to prior mi, lvef < 40%, and inducible vf or sustained vt at electrophysiological study with structural heart disease and spontaneous sustained vt, whether hemodynamically stable or unstable with syncope of undetermined origin with clinically relevant, hemodynamically significant sustained vt or vf induced at electrophysiological study clinical trials a number of clinical trials have demonstrated the superiority of the icd over aad (antiarrhythmic drugs) in the prevention of death from malignant arrhythmias. the scd-heft trial (published in 2005) showed a significant all-cause mortality benefit for patients with icd. congestive heart failure patients that were implanted with an icd had an all-cause death risk 23% lower than placebo and an absolute decrease in mortality of 7.2 percentage points after five years in the overall population.1 reporting in 1999, the antiarrhythmics versus implantable defibrillators (avid) trial consisted of 1,016 patients, and deaths in those treated with aad were more frequent (n = 122) compared with deaths in the icd groups (n = 80, p < 0.001). in 2002 the maditii trial showed benefit of icd treatment in patients after myocardial infarction with reduced left ventricular function (ef<30). initially icds were implanted via thoracotomy with defibrillator patches applied to the epicardium or pericardium. the device was attached via subcutaneous and transvenous leads to the device contained in a subcutaneous abdominal wall pocket. the device itself acts as an electrode. most icds nowadays are implanted transvenously with the devices placed in the left pectoral region similar to pacemakers. intravascular spring or coil electrodes are used to defibrillate. the devices have become smaller and less invasive as the technology advances. current icds weigh only 70 grams and are about 12.9 mm thick. a recent study by birnie and colleagues at the university of ottawa heart institute has demonstrated that icds are underused in both the united states and canada. an accompanying editorial by dr. chris simpson of queen's university explores some of the economic, geographic, social and political reasons for this. history the development of the icd was pioneered at sinai hospital in baltimore by a team including michel mirowski, morton mower, alois langer and william staewen. mirowski teamed up with mower and staewen and together they commenced their research in 1969 but it was 11 years before they treated their first patient. the work was commenced against much skepticism even by leading experts in the field of arrhythmias and sudden death. there was doubt that their ideas would ever become a clinical reality. in 1972 bernard lown, the inventor of the external defibrillator, and paul axelrod stated in the journal circulation – "the very rare patient who has frequent bouts of ventricular fibrillation is best treated in a coronary care unit and is better served by an effective anti-arrhythmic program or surgical correction of inadequate coronary blood flow or ventricular malfunction. in fact, the implanted defibrillator system represents an imperfect solution in search of a plausible and practical application." the problems to be overcome were the design of a system which would allow detection of ventricular fibrillation or ventricular tachycardia. despite the lack of financial backing and grants, they persisted and the first device was implanted in february 1980 at johns hopkins hospital by dr. levi watkins, jr. the first devices required the chest to be cut open and a mesh electrode sewn onto the heart; the pulse generator was placed in the abdomen. working mechanism icds constantly monitor the rate and rhythm of the heart and can deliver therapies, by way of an electrical shock, when the heart rate exceeds a preset number. more modern devices have software designed to attempt a discrimination between ventricular fibrillation and ventricular tachycardia (vt), and may try to pace the heart faster than its intrinsic rate in the case of vt, to try to break the tachycardia before it progresses to ventricular fibrillation. this is known as overdrive pacing, or anti-tachycardia pacing (atp). atp is only effective if the underlying rhythm is ventricular tachycardia, and is never effective if the rhythm is ventricular fibrillation. many modern icds use a combination of various methods to determine if a fast rhythm is normal, supraventricular tachycardia, ventricular tachycardia, or ventricular fibrillation. rate discrimination evaluates the rate of the lower chambers of the heart (the ventricles) and compares it to the rate in the upper chambers of the heart (the atria). if the rate in the atria is faster than or equal to the rate in the ventricles, then the rhythm is most likely not ventricular in origin, and is usually more benign. if this is the case, the icd does not provide any therapy, or withholds it for a programmable length of time. rhythm discrimination will see how regular a ventricular tachycardia is. generally, ventricular tachycardia is regular. if the rhythm is irregular, it is usually due to conduction of an irregular rhythm that originates in the atria, such as atrial fibrillation. in the picture, an example of torsades de pointes can be seen; this represents a form of irregular ventricular tachycardia. in this case, the icd will rely on rate, not regularity, to make the correct diagnosis. morphology discrimination checks the morphology of every ventricular beat and compares it to what the icd knows is the morphology of normally conducted ventricular impulse for the patient. this normal ventricular impulse is often an average of a multiple of normal beats of the patient acquired in the recent past and known as a template. the integration of these various parameters is very complex, and clinically, the occurrence of inappropriate therapy is still occasionally seen and a challenge for future software advancements. lead ii electrocardiogram (known as "rhythm strip") showing torsades de pointes being shocked by an implantable cardioverter-defibrillator back to the patient's baseline cardiac rhythm. living with an icd people who have an implanted cardioverter-defibrillator can live full lives. usually the icd does not improve the quality of life of the patient, although it may provide a strong degree of reassurance. as with a pacemaker, however, living with an icd does impose some restrictions on the person's lifestyle. a patient who had an icd fitted in 2016 following cardiac arrest described the icd as being "half the size of your mobile phone and a little bit thicker, in my chest and has two wires attached to it ... screwed into the bottom of your heart. ... i opted to have it fitted under my pectoral muscle, so you can't see it but you can see the wires in my chest - if you wanted to. some have them on top of the pectoral muscle, so you can see it." physical activities almost all forms of physical activities can be performed by patients with an icd. all forms of sports that do not pose a risk of damaging the icd or because of the underlying cardiomyopathy can be undertaken by the patient. special care should be taken not to put excessive strain on the shoulder, arm and torso area where the icd is implanted. doing so may damage the icd or the leads going from the icd generator to the patient's heart. particularly to be avoided are exercises that cause the clavicle to be pulled down towards the ribs, such as lifting weights with the arm, on the icd site, while standing. driving icd patients are prohibited from professional or commercial driving. a driving abstinence for private drivers is recommended following icd implantation, but the timeframe is variable depending on the country (between 3 and 6 months for secondary prevention and 1–4 weeks for primary prevention). following an appropriate icd-therapy, a driving ban is recommended for 3–6 months depending on the country. after inappropriate icd-therapy delivered for non-ventricular arrhythmias or due to the device malfunction, driving restrictions usually apply until the cause of the inappropriate therapy has been eliminated. electro-magnetic equipment equipment using large magnets or generating magnetic fields, or any similar environment, must be avoided by patients with an icd. as with other metallic objects, an icd is normally a contraindication to the use of magnetic resonance imaging (mri). however, several icd manufacturers have recently introduced mr-conditional icds, which allow the use of