mafenide mafenide mafenide (inn; usually as mafenide acetate, trade name sulfamylon) is a sulfonamide-type medication used as an antibiotic. it was approved by the fda in 1948. mafenideclinical datatrade namessulfamylon, mafylonahfs/drugs.commonographroutes ofadministrationtopicalatc coded06ba03 (who) legal statuslegal status in general: ℞ (prescription only) identifiers iupac name 4-(aminomethyl)benzenesulfonamide cas number138-39-6 npubchem cid3998chemspider3858 yunii58447s8p4lkeggd02351 ychemblchembl419 ycomptox dashboard (epa)dtxsid6047860 echa infocard100.004.843 chemical and physical dataformulac7h10n2o2smolar mass186.23 g·mol−13d model (jsmol)interactive image smiles o=s(=o)(c1ccc(cc1)cn)n inchi inchi=1s/c7h10n2o2s/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4h,5,8h2,(h2,9,10,11) ykey:tymrlrrvmhjftf-uhfffaoysa-n y ny (what is this?) (verify) uses mafenide is used to treat severe burns. it is used topically as an adjunctive therapy for second- and third-degree burns. it is bacteriostatic against many gram-positive and gram-negative organisms, including pseudomonas aeruginosa. some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns. mechanism of action mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns. adverse reactions adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis. drug interactions there are no significant interactions. contraindications mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment. dosage for use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. the burned area should be covered with cream at all times.