calcium channel blocker calcium channel blocker calcium channel blockers (ccb), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium (ca2+) through calcium channels. calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension. ccbs are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients. calcium channel blockers are also frequently used to alter heart rate (especially from atrial fibrillation), to prevent peripheral and cerebral vasospasm, and to reduce chest pain caused by angina pectoris. calcium channel blockersdrug classclass identifiersusehypertension, arrhythmia, cluster headacheatc codec08