megakaryocyte–erythroid progenitor cell megakaryocyte–erythroid progenitor cell megakaryocyte–erythroid progenitor cells, among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. hematopoietic stem cells can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. meps derive from the common myeloid progenitor lineage. megakaryocyte/erythrocyte progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte/erythrocyte progenitor cells. megakaryopoiesis: megakaryocyte actively forming platelets. hematopoiesis: mep differentiates into megakaryocytes and erythrocytes.