mir-650 microrna precursor family mir-650 microrna precursor family in molecular biology mir-650 microrna is a short rna molecule. micrornas function to regulate the expression levels of other genes by several mechanisms. mir-650identifierssymbolmir-650rfamrf00952 mirbase familymipf0000457other datarna typemicrornadomain(s)eukaryota;pdb structurespdbe diabetic and non-diabetic heart failure mir-650 is one of a group of six mirnas with altered expression levels in diabetic and non-diabetic heart failure. this altered expression corresponds to various enriched cardiac dysfunctions. ndrg2 regulation mir-650 has further been reported to target a homologous dna region in the promoter region of the ndrg2 gene. there is direct regulation of this gene at a transcriptional level, leading to repressed ndrg2 expression.