ajmalicine ajmalicine ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure. it has been marketed under numerous brand names including card-lamuran, circolene, cristanyl, duxil, duxor, hydroxysarpon, iskedyl, isosarpan, isquebral, lamuran, melanex, raunatin, saltucin co, salvalion, and sarpan. it is an alkaloid found naturally in various plants such as rauvolfia spp., catharanthus roseus, and mitragyna speciosa. ajmalicineclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status in general: ℞ (prescription only) identifiers iupac name (19α)-16,17-didehydro- 19-methyloxayohimban- 16-carboxylic acid methyl ester cas number483-04-5 ypubchem cid251561chemspider390541 yunii4qjl8ox71zchebichebi:2524chemblchembl123325 ycomptox dashboard (epa)dtxsid60904151 echa infocard100.006.900 chemical and physical dataformulac21h24n2o3molar mass352.434 g·mol−13d model (jsmol)interactive imagemelting point262.5 to 263 °c (504.5 to 505.4 °f) smiles o=c(oc)\c4=c\oc(c5cn3ccc1c(c2ccccc12)c3cc45)c inchi inchi=1s/c21h24n2o3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22h,7-10h2,1-2h3/t12-,15-,16+,19-/m0/s1 ykey:grtogortsdxsfk-xjtzbenfsa-n y ny (what is this?) (verify) ajmalicine is structurally related to yohimbine, rauwolscine, and other yohimban derivatives. like corynanthine, it acts as a α1-adrenergic receptor antagonist with preferential actions over α2-adrenergic receptors, underlying its hypotensive rather than hypertensive effects. additionally, it is a very strong inhibitor of the cyp2d6 liver enzyme, which is responsible for the breakdown of many drugs. its binding affinity at this receptor is 3.30 nm.