rimcazole rimcazole rimcazole is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor. sigma receptors are thought to be involved in the drug psychosis that can be induced by some drugs such as phencyclidine and cocaine, and rimcazole was originally researched as a potential antipsychotic with a different mechanism of action to traditional antipsychotic drugs. trials proved inconclusive and rimcazole was not pursued for this application, but other sigma antagonists continue to be researched for a variety of potential applications. rimcazole has been shown to reduce the effects of cocaine, and analogues of rimcazole have been shown to be highly effective at blocking the convulsions caused by cocaine overdose in animal models. rimcazoleclinical dataatc codenoneidentifiers iupac name 9--9h-carbazole cas number75859-04-0 ypubchem cid53389chemspider48221 nuniic3n1ps8cx1chemblchembl275707 ncomptox dashboard (epa)dtxsid7048162 chemical and physical dataformulac21h27n3molar mass321.459 g·mol−13d model (jsmol)interactive image smiles c1cn(c(n1)c)cccn2c3=cc=cc=c3c4=cc=cc=c42 inchi inchi=1s/c21h27n3/c1-16-14-23(15-17(2)22-16)12-7-13-24-20-10-5-3-8-18(20)19-9-4-6-11-21(19)24/h3-6,8-11,16-17,22h,7,12-15h2,1-2h3/t16-,17+ nkey:gudvqjxodnjrij-calchbbnsa-n n ny (what is this?) (verify)