insulin glulisine insulin glulisine insulin glulisine is a rapid-acting modified form of medical insulin that differs from human insulin in that the amino acid asparagine at position b3 is replaced by lysine and the lysine in position b29 is replaced by glutamic acid. it was developed by sanofi-aventis and approved for marketing by the fda in 2004; it is sold under the trade name apidra. when injected subcutaneously, it appears in the blood earlier than human insulin. when used as a meal time insulin, the dose is to be administered within 15 minutes before or 20 minutes after starting a meal. intravenous injections may also be used for extreme hyperglycemia, but must be performed under the supervision of a medical professional. insulin glulisinepdb: 6gv0​clinical datatrade namesapidra, apidra solostarahfs/drugs.commonographmedlineplusa607033license data eu ema: by inn us dailymed: insulin_glulisine pregnancycategory au: b3 routes ofadministrationsubcutaneous, intravenousatc codea10ab06 (who) legal statuslegal status au: s4 (prescription only) uk: pom (prescription only) us: ℞-only eu: rx-only identifierscas number207748-29-6 ndrugbankdb01309 ychemspidernoneunii7xiy785azdkeggd04540 ychemical and physical dataformulac258h384n64o78s6molar mass5822.64 g·mol−1 ny (what is this?) (verify) the most common side effects include hypoglycaemia (low blood glucose levels). medical uses insulin glulisine is indicated for the treatment of diabetes mellitus.