indacrinone indacrinone indacrinone is a loop diuretic. it can be used in patients of gout with hypertension as an antihypertensive because it decreases reabsorption of uric acid, while other diuretics increase it. indacrinoneidentifiers iupac name acetic acid cas number56049-88-8pubchem cid42266chemspider38545uniib926y9u4qnecha infocard100.054.496 chemical and physical dataformulac18h14cl2o4molar mass365.21 g·mol−13d model (jsmol)interactive image smiles cc1(cc2cc(c(c(c2c1=o)cl)cl)occ(=o)o)c3ccccc3 inchi inchi=1s/c18h14cl2o4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7h,8-9h2,1h3,(h,21,22)key:prkwvshzydozlp-uhfffaoysa-n chirality and biological activity indacrinone - chiral twins indacrinone is a chiral drug, with one chiral center and hence exists as mirror-image twins. (r)-enantiomer, the eutomer, is diuretic whereas the mirror-image version (s)-enantiomer counteracts side effect of the eutomer. here both the enantiomers contribute to the overall desired effect in different ways. as indicated earlier, the (r)- enantiomer is the pharmacologically active diuretic. like most other diuretics, the (r)-isomer possesses an undesirable side-effect of retaining uric acid. but the (s)-enantiomer, the distomer, has the property of assisting uric acid secretion (uricosuric effect), and, therefore, antagonizing the undesirable side-effects of the eutomer (uric-acid retention). it affords a good argument for the marketing of a racemic mixture. but studies exemplify that 9:1 mixture of the two enantiomers provides optimal therapeutic value.