ethoxzolamide ethoxzolamide ethoxzolamide (alternatively known as ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. it is used in the treatment of glaucoma and duodenal ulcers, and as a diuretic. it may also be used in the treatment of some forms of epilepsy. ethoxzolamideclinical dataatc codenonepharmacokinetic dataprotein binding~89%elimination half-life2.5–5.5 hoursidentifiers iupac name 6-ethoxy-1,3-benzothiazole-2-sulfonamide cas number452-35-7 ypubchem cid3295iuphar/bps6814drugbankdb00311 ychemspider3179 yuniiz52h4811wxkeggd02441 ychebichebi:101096 ychemblchembl18 ycomptox dashboard (epa)dtxsid1023021 echa infocard100.006.546 chemical and physical dataformulac9h10n2o3s2molar mass258.31 g·mol−13d model (jsmol)interactive image smiles o=s(=o)(c1nc2ccc(occ)cc2s1)n inchi inchi=1s/c9h10n2o3s2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5h,2h2,1h3,(h2,10,12,13) ykey:ouzwukmclibbog-uhfffaoysa-n y (verify) pharmacology ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. it also decreases carbonic anhydrase in the cns, increasing the seizure threshold. this reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor. mechanism of action ethoxzolamide binds and inhibits carbonic anhydrase i. carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. the inhibition of this enzyme effects the balance of applicable membrane equilibrium systems. synthesis ethoxzolamide synthesis: gb 795174; j. korman, u.s. patent 2,868,800 (1958, 1959 both to upjohn).