promestriene promestriene promestriene (inn) (brand names colpotrofin, colpotrophine, delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic estrogen which is used topically in a 1% cream formulation for the treatment of vaginal atrophy in women. it is the 3-propyl and 17β-methyl diether of estradiol and does not appear to convert into estradiol in the body. promestriene is minimally absorbed and appears to have negligible systemic estrogenic effect. the drug has been described as a tropic agent and antiseborrheic. it has not been found to be effective in the treatment of pattern hair loss or other conditions of cutaneous androgenization. promestriene was first introduced in france in 1974 and has been marketed in 34 countries worldwide. it has been used in millions of women. promestrieneclinical datatrade namescolpotrofin, colpotrophine, delipodermother namesestradiol 3-propyl 17β-methyl diether; 17β-methoxy-3-propoxyestra-1,3,5(10)-trieneroutes ofadministrationtopicaldrug classestrogen; estrogen esteratc codeg03ca09 (who) identifiers iupac name (8r,9s,13s,14s)-17-methoxy-13-methyl-3-propoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopentaphenanthrene cas number39219-28-8pubchem cid71717chemspider64767 yuniigxm4per6wzcomptox dashboard (epa)dtxsid2057730 echa infocard100.049.401 chemical and physical dataformulac22h32o2molar mass328.496 g·mol−13d model (jsmol)interactive image smiles cccoc1ccc2c(c1)cc32cc4(3ccc4oc)c inchi inchi=1s/c22h32o2/c1-4-13-24-16-6-8-17-15(14-16)5-7-19-18(17)11-12-22(2)20(19)9-10-21(22)23-3/h6,8,14,18-21h,4-5,7,9-13h2,1-3h3/t18-,19-,20+,21?,22+/m1/s1 nkey:iuwknlftjbhtsd-qikjaygvsa-n n (verify)