belnacasan belnacasan belnacasan (vx-765) is a drug developed by vertex pharmaceuticals which acts as a potent and selective inhibitor of the enzyme caspase 1. this enzyme is involved in inflammation and cell death, and consequently blocking its action may be useful for various medical applications, including treatment of epilepsy, arthritis, aiding recovery from heart attack and slowing the progression of alzheimer's disease. belnacasan is an orally active prodrug, being converted in the body to the active drug vrt-043198 (o-desethyl-belnacasan). however while belnacasan has proved well tolerated in human clinical trials, it has not shown sufficient efficacy to be approved for use for any of the applications suggested to date, though research continues into possible future uses of this or similar drugs. belnacasanclinical dataroutes ofadministrationoralidentifiers iupac name (2s)-1--3,3-dimethylbutanoyl]-n-pyrrolidine-2-carboxamide cas number273404-37-8pubchem cid11398092chemspider9572992unii00ole78529keggd10416chemical and physical dataformulac24h33cln4o6molar mass509.00 g·mol−13d model (jsmol)interactive image smiles cco3oc(=o)c3nc(=o)2cccn2c(=o)(nc(=o)c1ccc(n)c(cl)c1)c(c)(c)c inchi inchi=1s/c24h33cln4o6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23h,5-7,10,12,26h2,1-4h3,(h,27,32)(h,28,31)/t16-,17-,19+,23+/m0/s1key:sjddockbxfjejb-mokwfatosa-n