sch-48461 sch-48461 sch-48461 is a cholesterol absorption inhibitor. sch-48461 names preferred iupac name (3r,4s)-1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)azetidin-2-one identifiers cas number 148260-92-8 y 3d model (jsmol) interactive image chembl chembl23541 n chemspider 117230 n pubchem cid 132832 unii t0h910m40a y comptox dashboard (epa) dtxsid50933354 inchi inchi=1s/c26h27no3/c1-29-22-15-11-20(12-16-22)25-24(10-6-9-19-7-4-3-5-8-19)26(28)27(25)21-13-17-23(30-2)18-14-21/h3-5,7-8,11-18,24-25h,6,9-10h2,1-2h3/t24-,25-/m1/s1 nkey: imntvvouwfprsb-jwqcquifsa-n ninchi=1/c26h27no3/c1-29-22-15-11-20(12-16-22)25-24(10-6-9-19-7-4-3-5-8-19)26(28)27(25)21-13-17-23(30-2)18-14-21/h3-5,7-8,11-18,24-25h,6,9-10h2,1-2h3/t24-,25-/m1/s1key: imntvvouwfprsb-jwqcquifbu smiles coc1ccc(cc1)2(c(=o)n2c3ccc(cc3)oc)cccc4ccccc4 properties chemical formula c26h27no3 molar mass 401.49748 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references during the early phases of an npc1l1 inhibitor discovery program at schering-plough, conformationally restricted analogs based on the 2-azetidinone backbone were targeted by burnett and co-workers. early in the biological evaluation, it became apparent that even though the in vitro acat inhibitory activity of these analogs was modest (e.g., ic50 values of 2–50 mm), they exhibited significant activity in a cholesterol-fed hamster model (cfh). the discovery of the prototypical 2-azetidinone cai, sch-48461 (acat ic50 ~26 mm, ed50 of ce reduction in hamsters ~2.2 mpk) and the details of the first-generation sar have been described in detail.