xylometazoline xylometazoline xylometazoline, also spelled xylomethazoline, is a medication used to reduce symptoms of nasal congestion, allergic rhinitis, and sinusitis. use is not recommended for more than seven days. use is also not recommended in those less than three months of age and some say not less than 6 years of age. it is used directly in the nose as a spray or drops. xylometazolineclinical datapronunciation/ˌzaɪloʊˌmɛtəˈzoʊliːn/zy-lo-met-ə-zoh-leen trade namesotrivin, otrivine, othersahfs/drugs.commonographmedlineplusa608026license data us dailymed: xylometazoline pregnancycategory c dependenceliabilitymoderateroutes ofadministrationintranasal (spray or drops)drug classα1 and α2 adrenergic receptor agonistatc coder01aa07 (who) s01ga03 (who)legal statuslegal status in general: over-the-counter (otc) pharmacokinetic dataelimination half-life>10 secondsexcretionurinaryidentifiers iupac name 2--4,5-dihydro-1h-imidazole cas number526-36-3 npubchem cid5709iuphar/bps517drugbankdb06694 ychemspider5507 yuniiwpy40fth8kkeggd08684 ychemblchembl312448 ycomptox dashboard (epa)dtxsid8046957 echa infocard100.007.629 chemical and physical dataformulac16h24n2molar mass244.382 g·mol−13d model (jsmol)interactive image smiles n\1=c(\ncc/1)cc2c(cc(cc2c)c(c)(c)c)c inchi inchi=1s/c16h24n2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9h,6-7,10h2,1-5h3,(h,17,18) ykey:hucjfaomupxhdk-uhfffaoysa-n y ny (what is this?) (verify) side effects include trouble sleeping, irritation of the nose, nausea, nosebleed (3%), period pain (10%) and headache (3%). long term use (> 10 days) is not recommended due to a rhinitis medicamentosa when stopped. use is not recommended during pregnancy. xylometazoline is in the decongestant and alpha-adrenergic agonist families of medication. xylometazoline was patented in 1956 and came into medical use in 1959. it is on the world health organization's list of essential medicines. xylometazoline is available as a generic medication. mechanism of action the drug works by stimulating adrenergic receptors on the lamina propria of blood vessels in the nose. the decongestant effect is due to constriction of large veins in the nose which swell up during the inflammation of any infection or allergy of the nose. the smaller arteries are also constricted and this causes the colour of the nasal epithelium to be visibly paler after dosage. xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. it binds to α1 and α2 adrenergic receptors in the nasal mucosa. due to its sympathomimetic effects, it should not be used by people with high blood pressure, or other heart problems. extended usage of xylometazoline can result in decreased effectiveness or a buildup of tolerance against the drug. the number of receptors decreases, and when the administration of the drug is ceased, chronic congestion can occur; this is called rhinitis medicamentosa, commonly referred to as rebound congestion. moreover, long-term overdosing can cause degenerative changes in nasal mucous membranes that pose another health problem. society and culture brand names the most common name for over-the-counter products containing xylometazoline internationally is "otrivin" (used in australia, canada, estonia, greece, hungary, india, israel, jordan, netherlands, new zealand, norway, poland, south africa, sweden, vietnam, hong kong), "otrivine" (united kingdom, ireland, turkey), or "otriven" (germany). a product marketed as "otrivin oxy" contains oxymetazoline instead of xylometazoline. other product names used include antazol (square, in bangladesh), xylomet (opsonin, bangladesh), cirovin, klarigen (in denmark), nasolin, neo-rinoleina, novorin, olynth, otrinoz, galazolin (russia, ukraine, belarus), nasomist-x, otrix, rhinoset, zenfresh, naphthyzinium, xymelyn (in latvia), sinutab nasal spray, snup akut, sudafed, xylo-comod, xylolin (in uae), xylovit, olynth (in serbia and slovakia), meralys (in croatia) xynosine (in pakistan, afghanistan, kyrgyzstan and kazakhstan), xymelin, zymelin, xylostar, xylorin (in poland), nasobol, xylo mepha and others (switzerland), decozal (in jordan), nasic, orinox (romania), narhimed (italy), and nasa rhinathiol (belgium). as of 2021, no consumer products containing xylometazoline are marketed in the united states, however imported products containing xylometazoline are available online. formulations the standard adult solution strength is 0.1% w/v xylometazoline (or 1 mg per 1 ml solution), and the dose for children under 12 is usually 0.05% (0.5 mg/ml).