anti-neurofascin demyelinating diseases anti-neurofascin demyelinating diseases anti-neurofascin demyelinating diseases (anti-nf diseases) refers to health conditions engendered by auto-antibodies against neurofascins, which can produce both central and peripheral demyelination. some cases of combined central and peripheral demyelination (ccpd) could be produced by them. chronic inflammatory demyelinating polyneuropathy: some cases of cidp are reported to be produced by auto-antibodies against several neurofascin proteins. these proteins are present in the neurons and four of them have been reported to produce disease: nf186, nf180, nf166 and nf155. neuromyelitis optica: nf auto antibodies can also appear in nmo cases. these antibodies are more related to the peripheral nervous demyelination, but they were also found in nmo. multiple sclerosis: also antibodies against neurofascins nf-155 can also appear in atypical multiple sclerosis and nf-186 could be involved in subtypes of ms yielding an intersection between both conditions. around 10% of ms cases are now thought to be anti-nf cases. history the first report about a subgroup of ms patients with anti-nf and contactin 2 auto-antibodies was published in 2011