dyschromatosis universalis hereditaria dyschromatosis universalis hereditaria dyschromatosis universalis hereditaria is a type of pigmentation disorder of the skin. it is characterized by dark and light spots formed like lace in a generalized distribution. dyschromatosis universalis hereditariaspecialtydermatology both autosomal dominant and recessive inheritance have been reported with the disorder. it has been associated with mutations in genes sash1 and abcb6. it is a rare genodermatosis.