oxyphenisatine oxyphenisatine oxyphenisatine (or oxyphenisatin) is a laxative. it is closely related to bisacodyl, sodium picosulfate, and phenolphthalein. long-term use is associated with liver damage, and as a result, it was withdrawn in most countries in the early 1970s. the acetate derivative oxyphenisatine acetate was also once used as a laxative. oxyphenisatine names preferred iupac name 3,3-bis(4-hydroxyphenyl)-1,3-dihydro-2h-indol-2-one other names dihydroxydiphenylisatin; diphenolisatin; oxyphenisatin identifiers cas number 125-13-3 n 3d model (jsmol) interactive imageinteractive image chembl chembl245807 y chemspider 29053 y drugbank db04823 y echa infocard 100.004.299 ec number 204-728-1 kegg d08326 y pubchem cid 31315 unii 3bt0vqg2gq y comptox dashboard (epa) dtxsid5044528 inchi inchi=1s/c20h15no3/c22-15-9-5-13(6-10-15)20(14-7-11-16(23)12-8-14)17-3-1-2-4-18(17)21-19(20)24/h1-12,22-23h,(h,21,24) ykey: sjdacomxkwhbow-uhfffaoysa-n yinchi=1/c20h15no3/c22-15-9-5-13(6-10-15)20(14-7-11-16(23)12-8-14)17-3-1-2-4-18(17)21-19(20)24/h1-12,22-23h,(h,21,24)key: sjdacomxkwhbow-uhfffaoyau smiles oc1ccc(cc1)c1(c(=o)nc2ccccc12)c1ccc(o)cc1oc1=cc=c(c=c1)c1(c(=o)nc2=c1c=cc=c2)c1=cc=c(o)c=c1 properties chemical formula c20h15no3 molar mass 317.344 g·mol−1 log p 1.398 acidity (pka) 9.423 basicity (pkb) 4.574 pharmacology atc code a06ab01 (who) routes ofadministration oral, rectal legal status withdrawn except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references natural chemical compounds similar to oxyphenisatine may be present in prunes, but a recent review of the relevant scientific literature suggests that the laxative effect of prunes is due to other constituents including phenolic compounds (mainly neochlorogenic acids and chlorogenic acids) and sorbitol. synthesis the ketone group of isatin (1) is nonenolizable and has interesting properties. in strong acid it becomes protonated, and the oxygen can be replaced by electron rich moieties. oxyphenisatin synthesis: in 1885, it was reported that condensation of isatin with phenol 2 leads to 3, which is acetylated to (4). oxyphenisatin has cathartic properties. triacetyldiphenolisatin (laxagetten, unilax, trisatin), nicoxyphenisatin & cinnoxyphenisatin are chemical derivatives.