lutheran antigen system lutheran antigen system the lutheran antigen systems is a classification of human blood based on the presence of substances called lutheran antigens on the surfaces of red blood cells. there are 19 known lutheran antigens. physician mary n. crawford worked at the serum exchange of the children's hospital of philadelphia, where, in 1962, she discovered that she was one of a few people in the world with the rare blood type lu (a−b−) and that her blood might be donated to a patient in great britain. all of these antigens arise from variations in a gene called bcam (basal cell adhesion molecule). the system is based on the expression of two codominant alleles, designated lua and lub. the antigens aua and aub, known as the auberger antigens, were once thought to make up a separate blood group but were later shown to be lutheran antigens arising from variations in the bcam gene. the phenotypes lu(a+b−) and lu(a+b+) are found at various frequencies within populations. the lu(a−b+) phenotype is the most common in all populations, whereas the lu(a−b−) phenotype is uncommon. though present in the fetus, it is seldom the cause of erythroblastosis fetalis or of transfusion reactions. interpretation of antibody panel to detect patient antibodies towards the most relevant human blood group systems, including lutheran. further information: blood compatibility testing notes greer, john p. (2008). wintrobe's clinical hematology. lippincott williams & wilkins. p. 641. isbn 978-0-7817-6507-7. blood transfusion and transfusion medicineblood products whole blood platelets platelet transfusion red blood cells plasma fresh frozen plasma pf24 cryoprecipitate cryosupernatant white blood cells granulocyte transfusion blood substitutes general concepts blood bank blood donation blood management international society of blood transfusion isbt 128 methods apheresis (plasmapheresis, plateletpheresis, leukapheresis) exchange transfusion intraoperative blood salvage tests blood compatibility testing cross-matching coombs test kleihauer–betke test antibody elution monocyte monolayer assay transfusion reactionsand adverse effects transfusion hemosiderosis transfusion related acute lung injury transfusion associated circulatory overload transfusion-associated graft versus host disease febrile non-hemolytic transfusion reaction hemolytic reaction acute delayed serum sickness transfusion transmitted infection blood group systems blood types abo secretor status augustine cd59 chido-rodgers colton cromer diego dombrock duffy er fors gerbich gil glob hh ii indian jr jmh kanno kell (xk) kidd knops lan lewis lutheran lw mns ok p raph rh and rhag scianna sid t-tn vel xg yt other this article is issued from wikipedia. the text is licensed under creative commons - attribution - sharealike. additional terms may apply for the media files.