porges-meier reaction porges-meier reaction porges-meier reaction is a precipitation test used in the diagnosis of syphilis. it is an early flocculation test for syphilis. it is named for georg meier and otto porges. porges-meier reactionpurposetest in the diagnosis of syphilis background precipitate formation takes place in a serum by the addition of a solution of sodium glycocholate. this reaction, according to otto porges, only occurs in syphilis.