tioconazole tioconazole tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast. it is marketed under the brand names trosyd and gyno-trosyd (pfizer, now johnson & johnson). tioconazole ointments serve to treat women's vaginal yeast infections. they are available in one day doses, as opposed to the 7-day treatments commonly used in the past. tioconazoleclinical datatrade namesvagistat-1, 1-dayother namesthioconazoleahfs/drugs.commonographroutes ofadministrationtopicalatc coded01ac07 (who) g01af08 (who)legal statuslegal status us: otc identifiers iupac name (rs)-1--2-(2,4-dichlorophenyl)ethyl]-1h-imidazole cas number65899-73-2 ypubchem cid5482drugbankdb01007 nchemspider5282 nuniis57y5x1117keggd00890 ychebichebi:9604 nchemblchembl1200438 ncomptox dashboard (epa)dtxsid3046619 echa infocard100.059.958 chemical and physical dataformulac16h13cl3n2osmolar mass387.70 g·mol−1chiralityracemic mixture ny (what is this?) (verify) tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". it was patented in 1975 and approved for medical use in 1982. side effects side effects of vaginal tioconazole may include temporary burning itching, or irritation of the vagina. vaginal swelling or redness, difficulty or burning during urination, headache, abdominal pain, and upper respiratory tract infection have been reported by people using tioconazole. these side effects may be only temporary, and do not normally interfere with the patient's comfort enough to outweigh the result. synthesis antimycotic imidazole derivative. tiaconazole synthesis: a displacement reaction between 1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethanol and 2-chloro-3-(chloromethyl)thiophene is performed.