metiapine metiapine metiapine is a typical antipsychotic medication of the dibenzothiazepine group. there is scarce research on the safety and efficacy of metiapine in humans, though limited human trials exist. metiapineclinical datadrug classtypical antipsychoticidentifiers iupac name 8-methyl-6-(4-methylpiperazin-1-yl)benzobenzothiazepine cas number5800-19-1pubchem cid22047chemspider20718unii775d6d91j8keggd02672chemblchembl2106892comptox dashboard (epa)dtxsid7020891 chemical and physical dataformulac19h21n3smolar mass323.46 g·mol−13d model (jsmol)interactive image smiles cc1=cc2=c(c=c1)sc3=cc=cc=c3n=c2n4ccn(cc4)c inchi inchi=1s/c19h21n3s/c1-14-7-8-17-15(13-14)19(22-11-9-21(2)10-12-22)20-16-5-3-4-6-18(16)23-17/h3-8,13h,9-12h2,1-2h3key:ioepxyjohizygq-uhfffaoysa-n medical uses metiapine has been investigated for the treatment of schizophrenia. side effects like other typical antipsychotics, it has a high rate of extrapyramidal side effects. pharmacology metiapine has strong antidopaminergic effects and is classified as a typical (i.e., first-generation) antipsychotic. chemistry metiapine is a dibenzothiazepine derivative. like clothiapine, metiapine has a sulfur atom replacing the nitrogen atom found in dibenzapine derivative antipsychotics like clozapine. synthesis metiapine can be synthesized through the following mechanism: history metiapine was first discovered in the 1970s by marion merrell dow (now a part of sanofi). research a 2017 cochrane review provided guidance for a double-blind, randomized controlled trial of metiapine versus chlorpromazine for the treatment of schizophrenia, though the authors acknowledged that it is unlikely that any future trials will investigate the use of metiapine in humans. the available evidence for the use of metiapine is very limited.