idazoxan idazoxan idazoxan (inn) is a drug which is used in scientific research. it acts as both a selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. idazoxan has been under investigation as an antidepressant, but it did not reach the market as such. more recently, it is under investigation as an adjunctive treatment in schizophrenia. due to its alpha-2 receptor antagonism it is capable of enhancing therapeutic effects of antipsychotics, possibly by enhancing dopamine neurotransmission in the prefrontal cortex of the brain, a brain area thought to be involved in the pathogenesis of schizophrenia. idazoxanclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status in general: uncontrolled identifiers iupac name (±)-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1h-imidazole cas number79944-58-4 ypubchem cid54459chemspider49184 nuniiy310pa316bchemblchembl10316 ncomptox dashboard (epa)dtxsid6045161 chemical and physical dataformulac11h12n2o2molar mass204.229 g·mol−13d model (jsmol)interactive imagechiralityracemic mixture smiles c1cn=c(n1)c2coc3=cc=cc=c3o2 inchi inchi=1s/c11h12n2o2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10h,5-7h2,(h,12,13) nkey:hpmrfmkypgxpep-uhfffaoysa-n n ny (what is this?) (verify) alzheimer's research mice treated with idazoxan, which blocks the α2a receptor which regulates norepinephrine, behaved similarly to control animals despite still having amyloid-beta plaques in the brain, as a proof-of-concept experiment that dramatically reduced alzheimer's pathology and symptoms in two mouse models, potentially offering an immediate treatment for this devastating disease. synthesis note that the literature method claims that the old original patented procedure gives a different reaction product formed through a rearrangement. synthesis: old patent: new patent: the reaction of catechol (1) with 2-chloroacrylonitrile (2) gives 2-cyano-1,4-benzodioxan (3). pinner reaction with alcoholic hydrogen chloride leads to the iminoether, (4). treatment with ethylenediamine (5) gives the imidazoline ring affording idazoxin (6).