dimp (antiandrogen) dimp (antiandrogen) dimp (developmental code name ro 7-8117), or n-(3,5-dimethyl-4-isoxazolylmethyl)phthalimide, is a nonsteroidal antiandrogen (nsaa) structurally related to thalidomide (which also binds to and antagonizes the androgen receptor (ar)) that was first described in 1973 and was never marketed. along with flutamide, it was one of the earliest nsaas to be discovered, and for this reason, has been described as a "classical" nsaa. the drug is a selective, competitive, silent antagonist of the ar, although it is described as an "only relatively weak competitor". its relative binding affinity for the androgen receptor is about 2.6% of that of metribolone. dimp possesses no androgenic, estrogenic, progestogenic, or antigonadotropic activity, but it does reverse the antigonadotropic effects of testosterone, indicating that, like other pure ar antagonists, it is progonadotropic. dimpclinical dataother namesro 7-8117; n-(3,5-dimethyl-4-isoxazolylmethyl)phthalimidedrug classnonsteroidal antiandrogenidentifiers iupac name 2--2,3-dihydro-1h-isoindole-1,3-dione cas number39962-28-2 ypubchem cid135035chemspider118991uniibw49c59ulpchemblchembl1710671comptox dashboard (epa)dtxsid40193001 chemical and physical dataformulac14h12n2o3molar mass256.261 g·mol−13d model (jsmol)interactive image smiles cc1=c(c(=no1)c)cn2c(=o)c3=cc=cc=c3c2=o inchi inchi=1s/c14h12n2o3/c1-8-12(9(2)19-15-8)7-16-13(17)10-5-3-4-6-11(10)14(16)18/h3-6h,7h2,1-2h3key:shpruadeckzsmq-uhfffaoysa-n dimp is the lead antiandrogen of the phthalimide group of nonsteroidal ar ligands, and a variety of ar ligands with higher affinity for the ar have been derived from dimp and thalidomide.