polyostotic fibrous dysplasia polyostotic fibrous dysplasia polyostotic fibrous dysplasia is a form of fibrous dysplasia affecting more than one bone. fibrous dysplasia is a disorder where bone is replaced by fibrous tissue, leading to weak bones, uneven growth, and deformity. polyostotic fibrous dysplasiaother namesalbright's disease: 578 specialtyosteology mccune-albright syndrome includes polyostotic fibrous dysplasia as part of its presentation. when polyostotic fibrous dysplasia manifests in the long bones, limping results; when it manifests in the face, asymmetric growth of the face can result. one treatment that has been used is bisphosphonates.