andarine andarine andarine (developmental code names gtx-007, s-4) is an investigational selective androgen receptor modulator (sarm) developed by gtx, inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy (bph), using the nonsteroidal antiandrogen bicalutamide as a lead compound. andarineclinical dataother namesacetamidoxolutamide; androxolutamide; gtx-007; s-4atc codenonelegal statuslegal status us: investigational new drug identifiers iupac name (2s)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethyl-phenyl)-propionamide cas number401900-40-1 npubchem cid9824562iuphar/bps7849drugbankdb07423 ychemspider8000309 yunii7ut2hah49hchemblchembl125236 ycomptox dashboard (epa)dtxsid40193187 echa infocard100.230.653 chemical and physical dataformulac19h18f3n3o6molar mass441.363 g·mol−13d model (jsmol)interactive image smiles fc(f)(f)c1cc(ccc1()=o)nc(=o)(o)(coc2ccc(cc2)nc(=o)c)c inchi inchi=1s/c19h18f3n3o6/c1-11(26)23-12-3-6-14(7-4-12)31-10-18(2,28)17(27)24-13-5-8-16(25(29)30)15(9-13)19(20,21)22/h3-9,28h,10h2,1-2h3,(h,23,26)(h,24,27)/t18-/m0/s1 ykey:yvxvtlgidoacbj-sfhvurjksa-n y ny (what is this?) (verify) andarine is an orally active partial agonist of the androgen receptor (ar). in intact male rats, 0.5 mg andarine daily was shown to reduce prostate weight to 79.4%, and non-significantly increased levator ani muscle weight. in castrated male rats, this dose restored only 32.5% prostate weight, but 101% levator ani muscle weight this suggests that andarine is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist actions at the androgen receptor prevent the side effects associated with the antiandrogens traditionally used for treatment of bph.