hydromorphinol hydromorphinol hydromorphinol (ram-320, 14-hydroxydihydromorphine), also is an opiate analogue that is a derivative of morphine, where the 14-position has been hydroxylated and the 7,8- double bond saturated. it has similar effects to morphine such as sedation, analgesia and respiratory depression, but is twice as potent as morphine and has a steeper dose-response curve and longer half-life. it is used in medicine as the bitartrate salt (free base conversion ratio 0.643, molecular weight 471.5) and hydrochloride (free base conversion ratio 0.770, molecular weight 393.9) hydromorphinolclinical dataother nameshydromorphinol,14-hydroxy-7,8-dihydromorphine,ram-320atc codenonelegal statuslegal status au: s8 (controlled drug) ca: schedule i de: anlage i (authorized scientific use only) us: schedule i identifiers iupac name (5α,6α)-3,6,14-trihydroxy-4,5-epoxy-17-methylmorphinan cas number2183-56-4 y 2190-27-4pubchem cid5463858chemspider4576407 nunii1o00p9x5c1chemblchembl1951706 ncomptox dashboard (epa)dtxsid30176242 echa infocard100.016.878 chemical and physical dataformulac17h21no4molar mass303.358 g·mol−13d model (jsmol)interactive image smiles cn1cc234(cc2(1cc5=c3c(=c(c=c5)o)o4)o)o inchi inchi=1s/c17h21no4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,11-12,15,19-21h,4-8h2,1h3/t11-,12+,15-,16-,17+/m0/s1 nkey:aablhgpvoulici-brjglhkusa-n n ny (what is this?) (verify) it is also called α-oxymorphol, and oxymorphol is itself a mixture of hydromorphinol and 4,5α-epoxy-17-methylmorphinan-3,6β,14-triol, β-oxymorphol, which is different at position 6 on the morphine carbon skeleton. hydromorphinol was developed in austria in 1932. in the united states, it was never available and is classified as a schedule i drug with a dea acscn of 9301. the salts in use are the bitartrate (free base conversion ratio 0.643) and hydrochloride (0.770). the 2014 national aggregate manufacturing quota was 2 grams, unchanged from prior years. hydromorphinol is metabolised mainly in the liver in the same fashion as many other opioids and is itself a minor active metabolite of 14-hydroxydihydrocodeine, an uncommonly used opiate (but is therefore also an active metabolite of a first-order active metabolite of oxycodone). it is distributed under the trade name numorphan in some countries. it is controlled under the single convention on narcotic drugs.