estradiol 3-tetrahydropyranyl ether estradiol 3-tetrahydropyranyl ether estradiol 3-tetrahydropyranyl ether is a synthetic estrogen and estrogen ether which was never marketed. it has been reported to possess improved oral activity relative to estradiol. one study in animals found that it had 15 times the oral activity of estradiol. estradiol 3-tetrahydropyranyl etherclinical dataother namesnsc-86473; estra-1,3,5(10)-triene-17β-diol 3-(tetrahydropyran-2-yl) ether; 3-(tetrahydro-2h-pyran-2-yloxy)estra-1,3,5(10)-trien-3-olroutes ofadministrationby mouthdrug classestrogen; estrogen etheridentifiers iupac name (8r,9s,13s,14s,17s)-13-methyl-3-(oxan-2-yloxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopentaphenanthren-17-ol cas number41781-86-6 ypubchem cid257864chemspider226239unii2uc9xan8cvchemblchembl472508chemical and physical dataformulac23h32o3molar mass356.506 g·mol−13d model (jsmol)interactive image smiles c12cc3(1cc2o)ccc4=c3c=cc(=c4)oc5cccco5 inchi inchi=1s/c23h32o3/c1-23-12-11-18-17-8-6-16(26-22-4-2-3-13-25-22)14-15(17)5-7-19(18)20(23)9-10-21(23)24/h6,8,14,18-22,24h,2-5,7,9-13h2,1h3/t18-,19-,20+,21+,22?,23+/m1/s1key:bolmnljkdbcjib-cufsgndssa-n