noroxycodone noroxycodone noroxycodone is the major metabolite of the opioid analgesic oxycodone. it is formed from oxycodone in the liver via n-demethylation predominantly by cyp3a4. noroxycodone binds to and activates the μ-opioid receptor (mor) similarly to oxycodone, although with one-third of the affinity of oxycodone and 5- to 10-fold lower activational potency. however, although a potent mor agonist, noroxycodone poorly crosses the blood-brain-barrier into the central nervous system, and for this reason, is only minimally analgesic in comparison. noroxycodoneidentifiers iupac name (4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuroisoquinoline-7-one cas number57664-96-7pubchem cid5489120chemspider4590081unii95q949779dcomptox dashboard (epa)dtxsid60973261 echa infocard100.055.334 chemical and physical dataformulac17h19no4molar mass301.342 g·mol−13d model (jsmol)interactive image smiles coc1=c2c3=c(c45(3(ccn4)(o2)c(=o)cc5)o)c=c1 inchi inchi=1s/c17h19no4/c1-21-11-3-2-9-8-12-17(20)5-4-10(19)15-16(17,6-7-18-12)13(9)14(11)22-15/h2-3,12,15,18,20h,4-8h2,1h3/t12-,15+,16+,17-/m1/s1key:rikmcjunpcrfmw-iswurrpusa-n