akuammine akuammine akuammine (vincamajoridine) is an indole alkaloid. it is the most abundant alkaloid found in the seeds from the tree picralima nitida, commonly known as akuamma, comprising 0.56% of the dried powder. it has also been isolated from vinca major. akuammine is structurally related to yohimbine, mitragynine and more distantly voacangine, all of which are alkaloid plant products with pharmacological properties. akuammine names other names vincamajoridine identifiers cas number 3512-87-6 y 3d model (jsmol) interactive image chembl chembl484665 n chemspider 16735645 y pubchem cid 6441511 unii 0421aqv5w3 y inchi inchi=1s/c22h26n2o4/c1-4-13-11-24-8-7-21-16-9-14(25)5-6-17(16)23(2)22(21)18(24)10-15(13)20(21,12-28-22)19(26)27-3/h4-6,9,15,18,25h,7-8,10-12h2,1-3h3/b13-4+/t15-,18?,20?,21+,22-/m1/s1 ykey: yilkzadawnuttb-octhbtnbsa-n y smiles coc(=o)c46co35n(c)c1ccc(o)cc156ccn2c/c(=c\c)4cc23 properties chemical formula c22h26n2o4 molar mass 382.460 g·mol−1 melting point 225 °c (437 °f; 498 k) except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references pharmacology akuammine has antimalarial activity, and may be the primary constituent of p. nitida seeds responsible for this activity. akuammine is an opioid agonist with low affinity, selective for the mu-opioid receptor, when tested in vitro.