regadenoson regadenoson regadenoson, sold under the brand name lexiscan among others, is an a2a adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing. it produces hyperemia quickly and maintains it for a duration that is useful for radionuclide myocardial perfusion imaging. the selective nature of the drug makes it preferable to other stress agents such as adenosine, which are less selective and therefore cause more side-effects. regadenosonclinical datatrade nameslexiscan, rapiscanother namescvt-3146, 1-purin-2-yl]- n-methylpyrazole-4-carboxamideahfs/drugs.commonographlicense data eu ema: by inn us dailymed: regadenoson us fda: regadenoson routes ofadministrationintravenousatc codec01eb21 (who) legal statuslegal status us: ℞-only in general: ℞ (prescription only) identifiers iupac name 2-adenosine cas number313348-27-5 y 875148-45-1pubchem cid219024iuphar/bps5596drugbankdb06213 nchemspider189859 nunii7axv542lz4keggd05711 ychemblchembl1201750 ncomptox dashboard (epa)dtxsid4057712 echa infocard100.218.278 chemical and physical dataformulac15h18n8o5molar mass390.360 g·mol−13d model (jsmol)interactive image smiles cnc(=o)c1=cn(n=c1)c2=nc(=c3c(=n2)n(c=n3)4(((o4)co)o)o)n inchi inchi=1s/c15h18n8o5/c1-17-13(27)6-2-19-23(3-6)15-20-11(16)8-12(21-15)22(5-18-8)14-10(26)9(25)7(4-24)28-14/h2-3,5,7,9-10,14,24-26h,4h2,1h3,(h,17,27)(h2,16,20,21)/t7-,9-,10-,14-/m1/s1 nkey:lzpzphgjdagejz-akaijsegsa-n n ny (what is this?) (verify) regadenoson was approved by the united states food and drug administration on april 10, 2008, and is marketed by astellas pharma under the tradename lexiscan. it is approved for use in the european union and under the name of rapiscan. it is marketed by ge healthcare and is sold in both the united kingdom and germany. regadenoson was approved for use in the european union in september 2010. regadenoson has a two- to three-minute biological half-life, as compared with adenosine's ten-second half-life. as a result, regadenoson stress protocols use a single bolus, instead of the four- to six-minute continuous infusion that was needed with adenosine. whereas the adenosine infusion is weight based (140 mcg/kg/minute), regadenoson is administered as a 0.4 mg/5ml preloaded syringe dose that is standard for all weights. regadenoson stress tests are not affected by the presence of beta blockers, as regadenoson vasodilates via the adenosine pathway without stimulating beta adrenergic receptors. regadenoson can temporarily disrupt the integrity of the blood–brain barrier by inhibiting p-glycoprotein function.