diflucortolone valerate diflucortolone valerate diflucortolone valerate (also nerisone cream/ointment/fatty ointment, neriderm ointment, japanese ジフルコルトロン (jifurucorutoron) is a corticosteroid rated class 2 "potent" (100–150 times) in the new zealand topical steroid system. it is a white to creamy white crystalline powder. it is practically insoluble in water, freely soluble in dichloromethane and in dioxan, sparingly soluble in ether and slightly soluble in methyl alcohol. chemically, it is a corticosteroid esterified with valeric acid. it is commonly used topically in dermatology. the brand name is nerisone; its creams come in potencies of 0.1% and 0.3%. diflucortolone valerate names iupac name 6α,9-difluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate systematic iupac name 2-phenanthren-1-yl]-2-oxoethyl pentanoate other names afusona; diflucortolone 21-valerate identifiers cas number 59198-70-8 y 3d model (jsmol) interactive image chembl chembl65702 chemspider 82773 y echa infocard 100.056.032 pubchem cid 91670 unii 1a63z067c8 y comptox dashboard (epa) dtxsid1048598 inchi inchi=1s/c27h36f2o5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32h,5-7,10,12-14h2,1-4h3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1 ykey: hhjiuuamygbvsd-ytffsalgsa-n yinchi=1/c27h36f2o5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32h,5-7,10,12-14h2,1-4h3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1key: hhjiuuamygbvsd-ytffsalgby smiles o=c(occ(=o)32(c(o)4(f)/1(\c(=c/c(=o)\c=c\1)(f)c42c3c)c)c)cccc properties chemical formula c27h36f2o5 molar mass 478.577 g·mol−1 melting point 220 °c (428 °f; 493 k) except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). y verify (what is yn ?) infobox references