estrone sulfate (medication) estrone sulfate (medication) estrone sulfate (e1s) is an estrogen medication and naturally occurring steroid hormone. it is used in menopausal hormone therapy among other indications. as the sodium salt (sodium estrone sulfate), it is the major estrogen component of conjugated estrogens (premarin) and esterified estrogens (estratab, menest). in addition, e1s is used on its own as the piperazine salt estropipate (piperazine estrone sulfate; ogen). the compound also occurs as a major and important metabolite of estradiol and estrone. e1s is most commonly taken by mouth, but in the form of premarin can also be taken by parenteral routes such as transdermal, vaginal, and injection. estrone sulfate (medication)clinical dataother namese1s; oestrone sulfate; estrone 3-sulfate; estra-1,3,5(10)-trien-17-one 3-sulfateroutes ofadministrationby mouth, othersdrug classestrogen; estrogen esterpharmacokinetic dataprotein binding90%, to albumin, and not to shbgmetabolismdesulfation (via sts)metabolites• estrone• estradiolelimination half-life12 hoursidentifiers iupac name phenanthren-3-yl] hydrogen sulfate cas number481-97-0 y 438-67-5 (sodium)7280-37-7 (piperazine)pubchem cid3001028iuphar/bps4749drugbankdb04574 ychemspider2272513 yuniiqtl48n278kchebichebi:17474 ychemblchembl494753 ychemical and physical dataformulac18h22o5smolar mass350.43 g·mol−13d model (jsmol)interactive image smiles o=s(=o)(o)oc1cc4c(cc1)3cc2(c(=o)cc23cc4)c inchi inchi=1s/c18h22o5s/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16h,2,4,6-9h2,1h3,(h,20,21,22)/t14-,15-,16+,18+/m1/s1 ykey:jkkfkpjixzfssb-cbzijgrnsa-n y (verify) medical uses e1s is used in menopausal hormone therapy among other indications. pharmacology pharmacodynamics