pre-084 pre-084 pre-084 is a sigma receptor agonist, selective for the σ1 subtype. it has nootropic and antidepressant actions in animal studies, as well as antitussive and reinforcing effects. pre-084 increases the expression of gdnf. pre-084clinical dataatc codenoneidentifiers iupac name 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate cas number138847-85-5 ypubchem cid126402iuphar/bps6678chemspider112335 ncomptox dashboard (epa)dtxsid40160819 chemical and physical dataformulac19h27no3molar mass317.429 g·mol−13d model (jsmol)interactive image smiles c1ccccc1c2(ccccc2)c(=o)occn3ccocc3 inchi inchi=1s/c19h27no3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8h,2,5-6,9-16h2 nkey:rqhkzubcuzvzef-uhfffaoysa-n n ny (what is this?) (verify) synthesis patent: sodium hydride mediated alkylation between benzyl cyanide (1) and 1,5-dibromopentane (2) gives 1-phenylcyclohexanecarbonitrile (3). hydrolysis of the nitrile by treatment with aqueous potassium hydroxide in deg gives 1-phenylcyclohexanecarboxylic acid (4). halogenation with thionyl chloride gives 1-phenylcyclohexanecarbonyl chloride . this intermediate was not isolated but reacted with 2-morpholinoethanol (5) to give the ester and hence, completing the synthesis of pre084 (6).