flutemazepam flutemazepam flutemazepam, initially first synthesized in 1965, but wasn't further developed and described until a team at stabilimenti chimici farmaceutici riuniti spa in the mid 1970s. it is the fluorinated analogue of temazepam that has powerful hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties. it is most closely related in structure to temazepam, being the fluoro instead of chloro analogue. as a result, flutemazepam has been shown to have similar pharmacological properties to temazepam and nimetazepam. it has been found to be effective for the treatment of the most severe states of anxiety, panic attacks, and severe insomnia. furthermore, it is highly potent with 1 mg of flutemazepam being equivalent to 10 mg of diazepam. flutemazepam is highly effective for acute psychotic states, especially stimulant psychosis, violent behaviour, and aggression. flutemazepamclinical datapregnancycategory x routes ofadministrationoralatc codenonelegal statuslegal status ca: schedule iv de: npsg (industrial and scientific use only) uk: under psychoactive substances act us: schedule iv un: psychotropic schedule iv identifiers iupac name 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-3h-1,4-benzodiazepin-2-one cas number52391-89-6 npubchem cid40344chemspider36859 yuniij8u5694bcwchemblchembl291770 yecha infocard100.052.612 chemical and physical dataformulac16h12clfn2o2molar mass318.730 g·mol−13d model (jsmol)interactive image smiles fc1=cc=cc=c1c2=nc(c(n(c)c3=c2c=c(c=c3)cl)=o)o inchi inchi=1s/c16h12clfn2o2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21h,1h3 ykey:rmfywnfetxntiq-uhfffaoysa-n y ny (what is this?) (verify) it was first synthesized and described in 1965 by leo sternbach. in a test which compared a series of 3-fluorobenzodiazepine compounds in 1976, one of which was the 3-hydroxy benzodiazepine, flutemazepam. of the tested compounds (9 different 3-fluorobenzodiazepines including, a powerful compound known as n-desalkyl-3-hydroxyflurazepam). flutemazepam was the most potent: 20x more potent than temazepam, 10x more potent than diazepam and nitrazepam, 5x more potent than nimetazepam and roughly equipotent to a related 3-hydroxy benzodiazepine, lorazepam. it was also the most rapid-acting compound of the series via oral administration, as well as the most active and powerful anxiolytic, myorelaxant, tranquilizer, motor-impairing, amnesic, sedative-hypnotic, and anti-convulsive agent at doses as low as 0.5-1 mg range.