ub-612 ub-612 ub-612 is a covid-19 vaccine candidate developed by united biomedical asia, and vaxxinity, inc. it is a peptide vaccine. ub-612vaccine descriptiontargetsars-cov-2vaccine typepeptide subunitclinical dataroutes ofadministrationintramuscularidentifiersdrugbankdb16444 part of a series on thecovid-19 pandemicscientifically accurate atomic model of the external structure of sars-cov-2. each "ball" is an atom. covid-19 (disease) sars-cov-2 (virus) cases deaths timeline 2019 2020 january responses february responses march responses april responses may responses june responses july responses august responses september responses october responses november responses december responses 2021 january responses february responses march responses april responses may responses june responses july responses august responses september responses october responses november responses december responses 2022 january responses february responses march responses april responses may responses june 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card vaccine passports current vaccines coronavac covaxin convidecia janssen medigen moderna novavax oxford–astrazeneca pfizer–biontech sinopharm bibp sputnik v variants variants of concern alpha beta gamma delta omicron other variants epsilon zeta eta theta iota kappa lambda mu cluster 5 lineage b.1.617 economic impact and recession arts and culture aviation cannabis cinema films disney fashion financial markets food industry food security journalism music performing arts retail shipping television us sportscasting programs tourism video games by country canada india ireland malaysia new zealand russia uk us by sport association football baseball basketball combat sports cricket disc golf gaelic games gridiron football ice hockey motorsport rugby league impacts animals black people crime death rates by country disability domestic violence emergency evacuations education female environment hospitals language lgbt community long-term care media coverage mental health symptoms migration military notable deaths other health issues politics diplomacy popular culture protests pregnancy prisons religion catholic church hajj science and technology social media strikes suicides telehealth xenophobia and racism society ireland malaysia new zealand russia uk us covid-19 portal it is composed of sars-cov-2 s1-rbd protein and synthetic peptides representing t cell (th and ctl) epitopes on the nucleocapsid, spike and membrane proteins. the multitope composition is differentiated from other solely spike-protein based vaccines. by recognition against epitopes on spike (s1-rbd and s2) and non-spike (n and m) structure proteins, ub-612 provides b-cell and t-cell memory immunity and offers a potential as a universal vaccine to fend off the omicron variant and new emerging variants of concern. vaxxinity began seeking regulatory approval for ub-612 for use as a booster vaccine in the united kingdom and australia in 2022. technology ub-612 is a peptide vaccine incorporating multiple epitopes, including the spike protein receptor binding domain as well as other virus structural proteins. the spike protein peptide is fused to an fc domain of single-chain igg1, and the other six peptides are derived from highly conserved sequences from the spike, nucleocapsid, and membrane proteins of sars-cov-1 and sars-cov-2. it also contains a proprietary ubith1 peptide derived from the measles virus fusion protein, cpg oligonucleotides, and aluminum phosphate adjuvant to improve the immune response. it is produced in cho cells. clinical trials in september 2020, phase i clinical trials of ub-612 started in taiwan. and in january 2021, phase ii clinical trials began in taiwan. in february 2021, phase ii/iii clinical trials began. results from clinical trials showing positive safety and efficacy data were published in may 2022. in march 2022, vaxxinity started an international phase iii clinical trial of ub-612 as a heterologous booster vaccine against three approved platforms: mrna, adenovirus vector, and inactivated virus. the company announced positive topline data of the trial in december 2022.