medazepam medazepam medazepam is a drug that is a benzodiazepine derivative. it possesses anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. it is known by the following brand names: azepamid, nobrium, tranquirax (mixed with bevonium), rudotel, raporan, ansilan and mezapam. medazepam is a long-acting benzodiazepine drug. the half-life of medazepam is 36–200 hours. medazepamclinical datatrade namesrudotelahfs/drugs.cominternational drug namesroutes ofadministrationoralatc coden05ba03 (who) legal statuslegal status ca: schedule iv de: prescription only (anlage iii for higher doses) us: schedule iv pharmacokinetic databioavailability50–75% (сmax = 1–2 hours)protein binding>99%metabolismhepaticelimination half-life2 hours, 36–150 hours (terminal)excretionrenal (63–85%), biliary 15–37%identifiers iupac name 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine cas number2898-12-6 npubchem cid4041drugbanknone nchemspider3901 yuniip0j3387w3skeggd01292 ychemblchembl28333 ycomptox dashboard (epa)dtxsid1048708 echa infocard100.018.895 chemical and physical dataformulac16h15cln2molar mass270.76 g·mol−13d model (jsmol)interactive image smiles clc1=cc(c(c2=cc=cc=c2)=nccn3c)=c3c=c1 inchi inchi=1s/c16h15cln2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19/h2-8,11h,9-10h2,1h3 ykey:ylcxgbzizbevpz-uhfffaoysa-n y ny (what is this?) (verify) pharmacology medazepam acts as a prodrug to diazepam, as well as nordazepam, temazepam and oxazepam. benzodiazepine drugs including medazepam increase the inhibitory processes in the cerebral cortex by allosteric modulation of the gaba receptor. benzodiazepines may also act via micromolar benzodiazepine-binding sites as ca2+ channel blockers and significantly inhibited depolarization-sensitive calcium uptake in experiments with cell components from rat brains. this has been conjectured as a mechanism for high dose effects against seizures in a study. it has major active benzodiazepine metabolites, which gives it a more prolonged therapeutic effect after administration.