estradiol salicylate estradiol salicylate estradiol salicylate, or estradiol 3-salicylate, is a synthetic estrogen and estrogen ester – specifically, the c3 salicylic acid ester of estradiol – which was described in the late 1980s and was never marketed. it is a metabolite of estradiol acetylsalicylate, which appears to be very rapidly hydrolyzed into estradiol salicylate. estradiol salicylateclinical dataother namesestradiol 3-salicylateroutes ofadministrationby mouthdrug classestrogen; estrogen esteridentifiers iupac name phenanthren-3-yl] 2-hydroxybenzoate cas number113844-57-8 ypubchem cid188828chemspider164094uniimbq1mw0vstchemical and physical dataformulac25h28o4molar mass392.495 g·mol−13d model (jsmol)interactive image smiles c12cc3(1cc2o)ccc4=c3c=cc(=c4)oc(=o)c5=cc=cc=c5o inchi inchi=1s/c25h28o4/c1-25-13-12-18-17-9-7-16(29-24(28)20-4-2-3-5-22(20)26)14-15(17)6-8-19(18)21(25)10-11-23(25)27/h2-5,7,9,14,18-19,21,23,26-27h,6,8,10-13h2,1h3/t18-,19-,21+,23+,25+/m1/s1key:npjmhigaiirvgt-cwwqdxlcsa-n