tiamenidine tiamenidine tiamenidine (ban, usan, inn, also known as thiamenidine, hoe 440) is an imidazoline compound that shares many of the pharmacological properties of clonidine. it is a centrally-acting α2 adrenergic receptor agonist (ic50 = 9.1 nm). it also acts as an α1-adrenergic receptor agonist to a far lesser extent (ic50 = 4.85 μm). in hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. it was marketed (as tiamenidine hydrochloride) by sanofi-aventis under the brand name sundralen for the management of essential hypertension. tiamenidineclinical datatrade namessundralen, symcorad, symcoratc codec02ac (who) pharmacokinetic dataelimination half-life2.3–5 hoursidentifiers iupac name n-(2-chloro-4-methylthiophen-3-yl)-4,5-dihydro-1h-imidazol-2-amine cas number31428-61-2 npubchem cid39974chemspider36548 yunii195v08o55gkeggd06127 ychemblchembl295409 ycomptox dashboard (epa)dtxsid80185349 chemical and physical dataformulac8h10cln3smolar mass215.70 g·mol−13d model (jsmol)interactive image smiles clc2scc(c2n/c1=n/ccn1)c inchi inchi=1s/c8h10cln3s/c1-5-4-13-7(9)6(5)12-8-10-2-3-11-8/h4h,2-3h2,1h3,(h2,10,11,12) ykey:cvwilqhzfwrypb-uhfffaoysa-n y ny (what is this?) (verify) synthesis tiamenidine synthesis: reaction of thiourea 1 with methyl iodide gives the corresponding s-methyl analogue (2), followed by heating with ethylenediamine, completes the synthesis of tiamenidine (3).