potassium canrenoate potassium canrenoate potassium canrenoate (inn, jan) or canrenoate potassium (usan) (brand names venactone, soldactone), also known as aldadiene kalium, the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group. like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body. potassium canrenoateclinical dataother namessc-14266ahfs/drugs.cominternational drug namesroutes ofadministrationintravenousatc codec03da02 (who) pharmacokinetic datametabolismhepaticexcretionrenal and fecalidentifiers iupac name potassium 3-phenanthren-17-yl]propanoate cas number2181-04-6 npubchem cid23671691drugbankdb09015 nchemspider570975 yuniim671f9nleachemblchembl1371200 ncomptox dashboard (epa)dtxsid2045602 echa infocard100.016.868 chemical and physical dataformulac22h29ko4molar mass396.568 g·mol−13d model (jsmol)interactive image smiles .c(=o)cc3(o)cc24/c=c\c1=c\c(=o)cc1(4cc23c)c inchi inchi=1s/c22h30o4.k/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26h,5-12h2,1-2h3,(h,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1 ykey:jtzqchfughipdf-ryvbekkqsa-m y ny (what is this?) (verify) potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous) as opposed to oral administration. in the uk it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.