oculomucocutaneous syndrome oculomucocutaneous syndrome oculomucocutaneous syndrome is characterized by keratoconjunctivitis sicca (dry eyes) and the resulting scarring, fibrosis, metaplasia, and shrinkage of the conjunctiva. it is a drug side effect observed in practolol and eperisone. it is speculated that antibodies against drug metabolites cause the syndrome. oculomucocutaneous syndromespecialtyophthalmology