list of am cannabinoids list of am cannabinoids alexandros makriyannis is a professor in the department of medicinal chemistry at northeastern university, where his research group has synthesized many new compounds with cannabinoid activity. some of those are: cannabinoids and their affinities, selectivities and structures name class ki / nm at cb1 ki / nm at cb2 selectivity clogp structure description am-087dibenzopyran0.436.47 an analgesic cb1 agonist derived from δ8thc substituted with a side chain on the 3-position, roughly 100 times as potent as thc. am-251pyrazole derivative7.57.08 an inverse agonist at the cb1 cannabinoid receptor that is structurally related to sr141716a (rimonabant), but has a higher binding affinity. am-279 a schedule i substance in alabama. am-281 n-(morpholin-4-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1h-pyrazole-3-carboxamide am-35617.98685.55 a synthetically created stable chiral analog of anandamide, it acts on both cannabinoid receptors. am-374 palmitylsulfonyl fluoride am-381 stearylsulfonyl fluoride am-4047.02 an active metabolite of paracetamol (acetaminophen) and a likely inhibitor of fatty acid amide hydrolase (faah) am-4116.8052.0 an adamantyl-substituted derivative of δ8thc, it is a potent and fairly selective cb1 full agonist and a moderately potent cb2 agonist. am-63032.1cb2 (165×)4.19 a potent and selective inverse agonist for the cannabinoid receptor cb2 and a weak partial agonist at cb1. am-661 1-(n-methyl-2-piperidine)methyl-2-methyl-3-(2-iodo)benzoylindole am-6789.00 ± 5.002.94 ± 2.65cb25.68 another name for jwh-018, it is a full agonist at both cannabinoid receptors with some selectivity for cb2. am-67913.549.56.04 an iodobenzoylindole which acts as a moderately potent agonist for both cannabinoid receptors. am-6940.081.44cb1 (18×)5.54 an iodobenzoylindole which acts as a potent and selective agonist for the cb1 cannabinoid receptor. am-7358.97.4 3-bornyl-δ8-thc, a mixed cb1 / cb2 agonist. am-85522.358.6cb17.1 an analgesic derivative of δ8tetrahydrocannabinol, it is an agonist at both cb1 and cb2 with moderate selectivity for cb1. am-8815.395 a chlorine-substituted stereoisomer of anandamide. am-8839.9226 an allyl-substituted stereoisomer of anandamide. am-9051.25.3cb14.98 a potent and reasonably selective agonist for the cb1 cannabinoid receptor. am-9060.89.5cb14.98 a potent and dodecally selective agonist for the cb1 cannabinoid receptor. am-9192.23.4cb16.21 a potent agonist at both cb1 and cb2 with moderate selectivity for cb1. it is a derivative of hu-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. am-9262.24.3cb1 a potent agonist at both cb1 and cb2 with moderate selectivity for cb1. it is a derivative of hu-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. am-9381.20.3cb2 (4×)5.92 a potent agonist at both cb1 and cb2. it is a derivative of hu-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. am-11167.4 a dimethylated stereoisomer of anandamide. am-1172 an endocannabinoid analog specifically designed to be a potent and selective inhibitor of aea uptake that is resistant to faah hydrolysis. am-12203.8873.4cb1 (19×)4.73 a potent and selective analgesic cb1 agonist (as racemate). the (r) enantiomer has around 1000× higher affinity for cb1 than (s) enantiomer. am-122152.30.28cb2 (187×) a potent and selective cb2 agonist. am-12351.520.4cb1 (13×) a moderately cb1 selective agonist. am-12413.4cb2 (80×) a potent and selective analgesic cb2 agonist. am-1248cb1 a moderately potent agonist with some selectivity for cb1, containing an unusual 3-(adamant-1-oyl) substitution on the indole ring. am-1710cannabilactonecb2 (54×) a cb2 selective cannabilactone. acts as a dual cb2 agonist / cb1 antagonist. am-1714cannabilactonecb2 (490×)6.17 a cb2 selective cannabilactone. am-1902 a nonclassical cannabinoid am-22011.02.6cb15.18 a potent agonist at both cb1 and cb2 with moderate selectivity for cb1. am-22121.418.9cb1 a potent agonist at both cb1 and cb2 with dodecal selectivity for cb1. am-22133.030cb1 (10×) a potent agonist at both cb1 and cb2. am-22320.281.484.75 a potent agonist at both cb1 and cb2. am-22331.82.2cb15.09 the (r) enantiomer is potent and selective cb1 agonist used in 131i radiolabelled form to map distribution of cb1 receptors in brain. am-23890.16cb1 (26×)6 classical cannabinoid derivative. am-31023300026000 an analog of oleoylethanolamide, the endogenous agonist for proliferator-activated receptor α (pparα). it also acts as a weak cannabinoid agonist. am-40300.78.6cb1 (12×)6.17 a potent agonist at both cb1 and cb2, it is dodecally selective for cb1. it is a derivative of hu-210 and represents a hybrid structure between the classical and nonclassical cannabinoid families. am-40542.2cb1 (40×) a potent but slow-onset agonist. am-40560.0416.51 another name for hu-243, it is a potent agonist at both the cb1 and cb2 receptors. am-4113cb1 a cb1 selective neutral antagonist. am-6545cb14.06 a peripherally selective silent antagonist of cb1 receptors. am-7438 a potent agonist of cb1 and cb2 with reduced duration of action.