pseudophenmetrazine pseudophenmetrazine pseudophenmetrazine is a psychostimulant compound of the morpholine class. it is the n-demethylated and cis-configured analogue of phendimetrazine as well as the cis-configured stereoisomer of phenmetrazine. in addition, along with phenmetrazine, it is believed to be one of the active metabolites of phendimetrazine, which itself is inactive and behaves merely as a prodrug. relative to phenmetrazine, pseudophenmetrazine is of fairly low potency, acting as a modest releasing agent of norepinephrine (ec50 = 514 nm), while its (+)-enantiomer is a weak releaser of dopamine (ec50 = 1,457 nm) whereas its (−)-enantiomer is a weak reuptake inhibitor of dopamine (ki = 2,691 nm); together as a racemic mixture with the two enantiomers combined, pseudophenmetrazine behaves overall more as a dopamine reuptake inhibitor (ki = 2,630 nm), possibly due to the (+)-enantiomer blocking the uptake of the (−)-enantiomer into dopaminergic neurons and thus preventing it from inducing dopamine release. neither enantiomer has any significant effect on serotonin reuptake or release (both ki = >10,000 nm and ec50 = >10,000 nm, respectively). pseudophenmetrazineclinical dataatc codenoneidentifiers iupac name (±)-cis-3-methyl-2-phenylmorpholineor(±)-(2rs,3sr)-3-methyl-2-phenylmorpholine cas number13580-23-9 yunii5bxe22z857chemical and physical dataformulac11h15nomolar mass177.247 g·mol−1