cross syndrome cross syndrome cross–mckusick–breen syndrome (also known as "cross syndrome", "hypopigmentation and microphthalmia", and "oculocerebral-hypopigmentation syndrome") is an extremely rare disorder characterized by white skin, blond hair with yellow-gray metallic sheen, small eyes with cloudy corneas, jerky nystagmus, gingival fibromatosis and severe intellectual disability and physical retardation.: 867–8 cross syndromeother namesoculocerebral hypopigmentation syndrome, cross typecross syndrome is inherited in an autosomal recessive mannerspecialtyendocrinology it was characterized in 1967.