fipexide fipexide fipexide (attentil, vigilor) is a psychoactive drug of the piperazine chemical class which was developed in italy in 1983. it was used as a nootropic drug in italy and france, mainly for the treatment of senile dementia, but is no longer in common use due to the occurrence of rare adverse drug reactions including fever and hepatitis. fipexide is similar in action to other nootropic drugs such as piracetam and has a few similarities in chemical structure to centrophenoxine. chemically, it is an amide union of parachlorophenoxyacetate and methylenedioxybenzylpiperazine (mdbzp), and has been shown to metabolize to the latter, which plays a significant role in its effects. fipexideclinical dataatc coden06bx05 (who) identifiers iupac name 1--2-(4-chlorophenoxy)ethanone cas number34161-24-5 ypubchem cid3351chemspider3234 yuniitg44vme01dkeggd07345 ychemblchembl254857 ycomptox dashboard (epa)dtxsid5044657 echa infocard100.047.128 chemical and physical dataformulac20h21cln2o4molar mass388.85 g·mol−13d model (jsmol)interactive image smiles clc4ccc(occ(=o)n1ccn(cc1)cc2ccc3ococ3c2)cc4 inchi inchi=1s/c20h21cln2o4/c21-16-2-4-17(5-3-16)25-13-20(24)23-9-7-22(8-10-23)12-15-1-6-18-19(11-15)27-14-26-18/h1-6,11h,7-10,12-14h2 ykey:bfujhvvemmwlhc-uhfffaoysa-n y (verify) synthesis synthesis: patents: ptc alkylation of piperazine (1) with 2 equivalents of piperonyl chloride (2) in the presence of cetrimonium bromide gives 1,4-bis-piperonylpiperazine (3). base catalyzed treatment with 4-chlorophenoxyacetic acid (4) displaces one of the piperonyl groups to give fipexide (5).