factor for poor outcomes in a number of conditions, including periprosthetic joint infection treatment failure, and cirrhosis. amongst patients admitted to intensive care units (icus), hypoalbuminemia is specifically associated with icu-acquired muscle weakness. in chronic kidney disease, hypoalbuminemia is an indicator of frailty, which is itself associated with complications, mental distress, quality of life impairment, resource utilization, and mortality. epidemiology hypoalbuminemia is commonly found in hospitalized patients, patients in the icu, and the elderly within the hospital and the community. amongst elderly patients, prevalence can be as high as 70%, as shown in a study from southern brasil.