tifluadom tifluadom tifluadom is a benzodiazepine derivative with an unusual activity profile. unlike most benzodiazepines, tifluadom has no activity at the gabaa receptor, but instead is a selective agonist for the κ-opioid receptor. in accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite. tifluadomclinical dataroutes ofadministrationunknownatc codenoneidentifiers iupac name n-methyl]thiophene-3-carboxamide cas number83386-35-0 ypubchem cid115208iuphar/bps1667chemspider103084 yuniitf8x866l0ikeggd02694 ychemblchembl169703 yecha infocard100.073.052 chemical and physical dataformulac22h20fn3osmolar mass393.48 g·mol−13d model (jsmol)interactive image smiles o=c(ncc1n(c3ccccc3c(=n/c1)\c2ccccc2f)c)c4ccsc4 inchi inchi=1s/c22h20fn3os/c1-26-16(13-25-22(27)15-10-11-28-14-15)12-24-21(17-6-2-4-8-19(17)23)18-7-3-5-9-20(18)26/h2-11,14,16h,12-13h2,1h3,(h,25,27) ykey:npgabyhtdvggjk-uhfffaoysa-n y ny (what is this?) (verify) while tifluadom has several effects which might have potential uses in medicine, such as analgesia and appetite stimulation, κ-opioid agonists tend to produce undesirable effects in humans such as dysphoria and hallucinations, and so these drugs tend to only be used in scientific research. dysphoric effects are similar to those seen when using other κ-opioid receptor agonists like pentazocine and salvinorin a, and can be considered the opposite of morphine-induced euphoria. as such, kappa agonists are believed to have very limited abuse potential.