ml2-sa1 ml2-sa1 ml2-sa1 (evp-22) is a chemical compound which acts as an "agonist" (i.e. channel opener) for the trpml2 calcium channel, with high selectivity for trpml2 and no significant activity at the related trpml1 and trpml3 channels. it has been used to demonstrate the role of trpm2 in immune system function, both triggering release of the chemokine ccl2 from macrophages and stimulating macrophage migration and endolysosomal trafficking. ml2-sa1identifiers iupac name 5-(2,6-dichlorophenyl)-3-oxa-4-azatricyclodec-4-ene pubchem cid137553170chemical and physical dataformulac14h13cl2nomolar mass282.16 g·mol−13d model (jsmol)interactive image smiles clc4cccc(cl)c4c3=noc2c1cc(cc1)c23 inchi inchi=1s/c14h13cl2no/c15-9-2-1-3-10(16)12(9)13-11-7-4-5-8(6-7)14(11)18-17-13/h1-3,7-8,11,14h,4-6h2key:nbxvmfmmtkyfqp-uhfffaoysa-n