norfenfluramine norfenfluramine norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family that behaves as a serotonin and norepinephrine releasing agent and potent 5-ht2a, 5-ht2b, and 5-ht2c agonist. the action of norfenfluramine on 5-ht2b receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. this side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in europe, as both fenfluramine and benfluorex form norfenfluramine as an active metabolite. it is a human taar1 agonist. norfenfluramine names preferred iupac name 1-propan-2-amine other names 3-trifluoromethylamphetamine identifiers cas number 19036-73-8 y 3d model (jsmol) interactive image chemspider 15108 y iuphar/bps 215 pubchem cid 15897 unii clx07a6ziy y comptox dashboard (epa) dtxsid60904717 inchi inchi=1s/c10h12f3n/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7h,5,14h2,1h3 ykey: mlbhfbkzuplwbd-uhfffaoysa-n yinchi=1/c10h12f3n/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7h,5,14h2,1h3key: mlbhfbkzuplwbd-uhfffaoyar smiles fc(f)(f)c1cccc(c1)cc(n)c properties chemical formula c10h12f3n molar mass 203.208 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). y verify (what is yn ?) infobox references