4-pro-dmt 4-pro-dmt 4-propionoxy-n,n-dimethyltryptamine (4-pro-dmt, or o-propionylpsilocin) is a synthetic psychedelic drug from the tryptamine family with psychedelic effects, and is believed to act as a prodrug for psilocin. it produces a head-twitch response in mice. it has been sold online as a designer drug since may 2019. it was first identified as a new psychoactive substance in sweden, in july 2019. 4-pro-dmtclinical dataother names4-propanoyloxy dmtidentifiers iupac name -1h-indol-4-yl] propanoate cas number1373882-11-1pubchem cid155907598chemspider84400449uniib9bf25hph4chemical and physical dataformulac15h20n2o2molar mass260.337 g·mol−13d model (jsmol)interactive image smiles ccc(=o)oc1=cc=cc2=c1c(=cn2)ccn(c)c inchi inchi=1s/c15h20n2o2/c1-4-14(18)19-13-7-5-6-12-15(13)11(10-16-12)8-9-17(2)3/h5-7,10,16h,4,8-9h2,1-3h3key:kuogxpdqorrhed-uhfffaoysa-n recreational use 4-pro-dmt crystals dosage 4-pro-dmt is reported to be orally active, though its threshold and duration in humans have not been formally studied. effects the effects of 4-pro-dmt are broadly comparable to those of other serotonergic psychedelics such as lsd and psilocybin. pharmacology pharmacodynamics 4-pro-dmt is theorized to be a serotonergic psychedelic, and is partial agonist of the 5-ht1d, 5-ht1b and 5-ht1a serotonin receptors. toxicity very little data about the toxicity or pharmacology of 4-pro-dmt is known. its chemical structure and pharmacological activity are similar to psilacetin, a compound which isn't associated with compulsive use or physical dependence. however, due to lack of research and data, it cannot be definitively concluded that its pharmacological actions in the human body do not differ from those of psilacetin. to date, there have been no reported deaths from 4-pro-dmt.