mast cell stabilizer mast cell stabilizer mast cell stabilizers are medications used to prevent or control certain allergic disorders. they block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. one suspected pharmacodynamic mechanism is the blocking of ige-regulated calcium channels. without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. cromolyn nedocromil as inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis. finally, in oral form, they are used to treat the rare condition of mastocytosis. examples mast cell stabilizer medications include: cromoglicic acid (cromolyn/cromoglycate) lodoxamide nedocromil ketotifen olopatadine bepotastine alcaftadine azelastine vitamin d β2-adrenergic agonists