ceftizoxime ceftizoxime ceftizoxime is a third-generation cephalosporin available for parenteral administration. unlike other third-generation cephalosporins, the whole c-3 side chain in ceftizoxime has been removed to prevent deactivation by hydrolytic enzymes. it rather resembles cefotaxime in its properties, but is not subject to metabolism. it was removed from the us market in 2007. ceftizoximeclinical datatrade namescefizoxahfs/drugs.comconsumer drug informationmedlineplusa684043atc codej01dd07 (who) identifiers iupac name (6r,7r)-7--8-oxo-5-thia-1-azabicyclooct-2-ene-2-carboxylic acid cas number68401-81-0 68401-82-1pubchem cid6533629chemspider5018818uniic43c467dpekeggd07658chemblchembl528comptox dashboard (epa)dtxsid5022772 echa infocard100.210.846 chemical and physical dataformulac13h13n5o5s2molar mass383.40 g·mol−1 synthesis injectable third generation cephalosporin antibiotic related to cefotaxime, q.v. exhibits broad spectrum activity and resistance to β-lactamase hydrolysis. ceftizoxime synthesis: