centrum semiovale centrum semiovale in neuroanatomy, the centrum semiovale, semioval center or centrum ovale is the central area of white matter found underneath the cerebral cortex. the white matter, located in each hemisphere between the cerebral cortex and nuclei, as a whole has a semioval shape. it consists of cortical projection fibers, association fibers and cortical fibers. it continues ventrally as the corona radiata. centrum semiovaledissection of cortex and brain-stem showing association fibers and island of reil after removal of its superficial gray substance.human brain right dissected lateral view descriptiondetailsidentifierslatincentrum semiovaleneuronames190ta25574fma61939anatomical terms of neuroanatomy