chlorphentermine chlorphentermine chlorphentermine (trade names apsedon, desopimon, lucofen) is a serotonergic appetite suppressant of the amphetamine family. developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine, which is still in current use. chlorphentermineclinical dataother namesp-chloro-α,α-dimethylphenethylamineroutes ofadministrationoral, insufflated, rectalatc codea08aa (who) legal statuslegal status ca: schedule iv uk: class c us: schedule iii (but withdrawn from market) pharmacokinetic dataelimination half-life40 hoursexcretionrenalidentifiers iupac name 1-(4-chlorophenyl)-2-methylpropan-2-amine cas number461-78-9 n 151-06-4pubchem cid10007drugbankdb01556 ychemspider9613 yuniinhw07912o7keggc07559 ychemblchembl1201269 ncomptox dashboard (epa)dtxsid0022806 echa infocard100.006.651 chemical and physical dataformulac10h14clnmolar mass183.68 g·mol−13d model (jsmol)interactive image smiles clc1ccc(cc1)cc(n)(c)c inchi inchi=1s/c10h14cln/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6h,7,12h2,1-2h3 ykey:zckamnxuhhnzln-uhfffaoysa-n y ny (what is this?) (verify) chlorphentermine acts as a highly selective serotonin releasing agent (sra). it is not a psychostimulant and has little or no abuse potential, but is classed as a schedule iii drug in the usa due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. it is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use. the plasma half-life is about five days. it was withdrawn from the market in the uk in 1974.