mibefradil mibefradil mibefradil (trade name posicor) was a pharmaceutical drug used for the treatment of hypertension and chronic angina pectoris. it is a nonselective calcium channel blocker. it was voluntary pulled from the market ten months after fda approval, citing potential serious health hazards shown in post release studies. mibefradilclinical datatrade namesposicorahfs/drugs.commicromedex detailed consumer informationmedlineplusa607007routes ofadministrationby mouth (tablets)atc codec08cx01 (who) legal statuslegal status withdrawn from market pharmacokinetic databioavailability70%protein binding>99%metabolismliver (cyp3a4)elimination half-life17–25 hoursidentifiers iupac name (1s,2s)-2-(2-((3-(1h-benzoimidazol-2-yl)propyl) (methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl 2-methoxyacetate cas number116644-53-2 ypubchem cid60662iuphar/bps2522drugbankdb01388 nchemspider54673 nunii27b90x776akeggd08217 ychemblchembl45816 npdb ligandmwv (pdbe, rcsb pdb)comptox dashboard (epa)dtxsid1023318 chemical and physical dataformulac29h38fn3o3molar mass495.639 g·mol−13d model (jsmol)interactive imagemelting point128 °c (262 °f) (dihydrochloride salt) smiles cc(c)1c2=c(cc1(ccn(c)cccc3=nc4=cc=cc=c4n3)oc(=o)coc)c=c(c=c2)f inchi inchi=1s/c29h38fn3o3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28h,7,10,13-17,19h2,1-4h3,(h,31,32)/t28-,29-/m0/s1 nkey:hbnpjjilloyfju-vmprefpwsa-n n ny (what is this?) (verify) the mechanism of action of mibefradil is characterized by the selective blockade of transient, low-voltage-activated (t-type) calcium channels over long-lasting, high-voltage-activated (l-type) calcium channels, which is probably responsible for many of its unique properties. on june 8, 1998, roche announced the voluntary withdrawal of the drug from the market, one year after approval by the fda, due to the potential for drug interactions, some of them deadly, which may occur when it is taken together with some other medications. synthesis mibefradil synthesis: yu 22988 zw 20087