as a major plot element in fallout, fallout 2 and fallout 3. super mutants also appear in fallout: new vegas and fallout 4. foxdie metal gear solid foxdie is a virus responsible for killing people with certain genetic markers via cardiac arrest. foxdie is given to protagonist solid snake by dr. naomi hunter, only it is engineered to go off at an indeterminate time. foxdie was also the cause of death of liquid snake, decoy octopus (impersonating darpa chief donald anderson), and the armstech president. frenzy virus monster hunter 4 the frenzy virus is an infectious disease originating in monsters gore magala and shagaru magala. it is transmitted through the air via black mistlike particles, or through contact with an infected specimen. symptoms of the frenzy virus in monsters include heightened aggression, increased physical prowess, and a significantly shortened lifespan. in rare cases, a sufficiently powerful monster can overcome the virus. such monsters are referred to as apex monsters, and they obtain a strengthened version of the benefits of the virus without the main drawbacks. player controlled hunters can also be infected, which gives them a limited amount of time before the virus activates and temporarily removes their natural regeneration. it also makes attacks from gore magala, chaotic gore magala (a gore magala that has not properly shed its skin and become shagaru magala) shagaru magala, or a frenzied monster much more lethal than normal. if a hunter manages to show enough aggression before this activation occurs, they overcome the virus, avoiding all negative effects and gaining a short-term increase in physical ability. g-virus resident evil series a mutagenic pathogen which causes the host to become a big, constantly evolving, practically unstoppable killing machine, with exceedingly high attack power and immense vitality, in addition to the ability to regenerate and mutate so quickly the carrier virtually loses its mortality. the purified virus can be injected directly into the host, or a mutated host can implant a small larvae, called a g-embryo into another host. the latter mode of transmission is most successful when the host and the new victim are genetically similar. the virus would later be merged with the t-virus by umbrella scientists in an attempt to balance the g-virus' rapid evolution with the t-virus' stability, creating an extremely dangerous, electromagnetic-capable variant called the t+g virus. gagne michigan: report from hell an experimental bioweapon that was developed in a consortium by the zaka conglomerate, the u.s. government, and the u.s. military. it is a mutagenic virus that can be transmitted in the air and by contact with body fluids. gagne takes the form of a thick fog that has covered the entirety of chicago, illinois and is causing animals and people to horrifically transform into grotesque monsters with large maws that can spawn leech-like larvae. stage 1: no discernible changes in physical appearance and body temperature. actions become sluggish. stage 2: subject begins to spawn leech-like larvae which are violently spewed from the mouth. stage 3: subject undergoes horrific transformation and becomes aggressive and sensitive to nearby sounds. gangliated utrophin immuno latency toxin (guilt) trauma center: under the knife a series of eight parasitic pathogens created by the medical-terrorist group delphi. despite its ingame introduction as a toxin, guilt is referred as a "moving tumor", but behaves more like a parasite. during ingame sequences where the player operates on patients, guilt diseases are normally shown as a pseudo-sentient core that attacks the patient from within, using lacerations, tumors and other ailments. individual strains are named after greek days of the week (kyriaki, deftera, triti, tetarti, pempti, paraskevi, savato), the only exception being the eighth strain, called "bliss". neo-guilt strains, which were developed independently from the original guilt project, introduce four more strains (nous, bythos, sige, aletheia). some guilt survivors were also inflicted with a variation of the disease, dubbed the pgs (post-guilt syndrome). genophage mass effect a biological weapon created by the salarians and deployed against the krogan species, designed to dramatically reduce the normal birth rate by infecting the species with genetic mutations. the plague causes most krogan pregnancies to end in stillbirth, with most fetuses never even reaching that stage of development. gray death deus ex a global plague engineered using nanotechnology within a universal constructor by majestic-12, the gray death virus is actually a hybrid (cyborganic) disease of biological and mechanical structures. it is based on the adverse and ultimately lethal effects of nanotechnology on an unmodified human body. named the gray death because of the gray patches of discolored scar tissue that cover its victims' skins, if and when the disease is cured. symptoms include the aforementioned discoloration of the skin, coughing, physical pain and death. hyper-evolutionary virus starcraft the hyper-evolutionary virus is a retrovirus produced by zerg queens. it is used to mutate "lesser" creatures into zerg warrior breeds. only a small percent of humanity is fully compatible, who retain personality, intelligence, and psionics. others mutate into living bombs, utterly dominated by the overmind. it has a re-animation side-effect. it is transmissible through fluid transfer only, much like solanum. "harran virus" (previously unknown) dying light a previously mysterious rabies-like pathogen, the harran virus was spread within the city of harran (likely based in turkey) to epidemic proportions, placing the city under quarantine. as a result, many victims of the virus are initially turned into aggressive and athletic infected (called "virals") before decaying into hordes of shambling and cannibalistic infected (called "biters"). with this said, some of those infected by the virus may mutate into various creatures. once the sun goes down, the pathogen alters the infected's motor-coordination and sensory, resulting the sluggish infected turning agile and vicious at night (called "night walkers") and mutated inhuman infected (called "volatiles") with severe muscle exposure coming out only at night to hunt any uninfected survivors. during the night, the infected's primary weakness is ultraviolet light, while the infected during the day have no specified weakness. incuritis apollo justice: ace attorney a rare, but lethal disease, curable only through the use of a medicine made from the borginian cocoon. the cure is very difficult to make, and if made incorrectly, it is a deadly poison, and thus the exportation of such a cocoon is illegal. the chief justice's son has the disease. the infection hollow knight the disease causes bright orange boils to appear on the victim's skin, as well as turn their eyes and blood a rich orange. the first symptom of being infected is having a dream about the radiance, a long forgotten god, and it greatly increases the strength and physical size of the victim, but removes all conscious thought, making the victim mindless and violent. those who resist the infection merely become consumed by it more and more. some characters intentionally take in the infection, as they see the exchange of free will for increased strength beneficial to themselves. along with plaguing the minds of millions of victims, it can also reanimate corpses and manifest itself in the form of floating, single-celled organisms, though the true extent of the infection's abilities is never properly seen. it is stated that the infection, and by consequence infected victims and corpses, have a sickly sweet taste, and areas heavily affected by the disease will have a thick air about them. the infection is easily spread and caused the downfall of hallownest, the kingdom in which the game takes place. kepral's syndrome mass effect 2 a degenerative respiratory disease unique to drell, occurring as a result of their transition from their desert homeworld of rakhana to the hanar ocean homeworld of kahje; cumulative exposure to moisture results in a condition that erodes their capacity to absorb oxygen into their lungs, eventually resulting in death. it is noncommunicable, and there is currently no known cure, though its progression can be slowed through exposure to warm, arid environments. kharaa bacterium subnautica, subnautica: below zero kharaa is an alien bacterium discovered by the precursor race during the exploration of an unknown planet. it seems to have completely taken over planet 4546b. it is described in the degasi pdas as "part of the ecosystem", with further statements that the degasi survivors were infected at some point - as stated by bart torgal while discussing the flu-like symptoms the crew was experiencing. early on, the player's pda and lifepod will make note of the high levels of bacterial infection in the water. the pda notes that kharaa is unlike any infection thus discovered in human history, suggesting that kharaa's biological design is far more drastic compared to diseases such as yersinia pestis.the pda estimates that kharaa incubates in two weeks and quickly kills its host after it reaches a substantial infection level. it accomplishes this by shutting down the immune system (already making the infected host susceptible to other diseases) and causing genetic mutation to the host's dna, and causing alterations to the body structure, eventually leading to a total shutdown of the organism due to its inability to keep functioning properly. las plagas resident evil series a parasitic organism which can infect a variety of hosts, including humans. it has the ability to control its host's behavior, inducing a hive-like mentality among the infected and extreme hostility towards uninfected individuals. the infected retain most of the characteristics of humans such as fine motor skills as seen through their use of simple weapons such as scythes and axes, and more complicated weapons such as chainsaws and chainguns. they are seen to obey "queen" parasites, much like ants. litterbug zoo tycoon 2 a disease that affects humans and extinct animals. animals that are affected grow tired quickly. it is caused by trash and is cured by saguaro cactus, boxelder, and monkey puzzle trees. m2448 virus (the freak virus) crackdown 2 the virus called m2448 was created by catalina thorne, the leader of cell, during her time as a medical student working for the agency. she conducted secret experiments of the virus but was discovered by the agency and was kicked off the agency-sponsored medical programme. she was enraged by this and wanted revenge on the agency because it apparently ruined her life. to get her revenge she offered free vaccinations to the people of unity heights (formerly "the corridor"), she was actually vaccinating her victims with the m2448 virus which tuned them into freaks. the virus spread across unity heights very quickly and soon made its way into the two other boroughs of pacific city. manticore call of duty: advanced warfare a bio-weapon that was devised to target specific genotypes, and would kill anyone not in the atlas database. named after the persian mythical creature. marker: dna sequence dead space the human colony on planet aegis discovered an alien marker, which contained complex and powerful dna sequences that enabled dead cells to revive. unfortunately, one of the scientists working on the dna sequence dropped the dish containing the engineered cells. the cells eventually infected one scientist, which then led to altered mutations on the human body. maverick virus mega man x a virus that affects reploids. causes violent insanity and is passed by touch. victims can sometimes retain their intellect. combination with the intelligence of the maverick hunter sigma created a variant form called the sigma virus, which is airborne. mega man x can be harmed, but not mentally suborned, by this virus. zero is actually strengthened by exposure, due to his unique status. the zero virus is a further evolved, faster version. mtamashiro-66 virus halo mtamashiro-66 virus (often shortened to mta66) as depicted in the halo book series is a virus that affects the nervous system of several species of canine. ne-alpha parasite resident evil series the ne-alpha, or nemesis alpha, parasite has an immunity to the t-virus, and is used to protect the higher brain functions of b.o.w.'s. however, if the b.o.w. is incompatible with the parasite, they die inside of twenty minutes. if they are compatible, however, the parasite acts as a second brain, taking over the functions of the t-virus ravaged host's brain. the host increases in size and strength; and become hardy enough to survive multiple gunshot wounds. the parasite's tentacles become threaded throughout the host's entire body; and can be utilized as a weapon. ne-beta parasite resident evil series the ne-beta (nemesis beta) parasite is an