arthrogryposis–renal dysfunction–cholestasis syndrome arthrogryposis–renal dysfunction–cholestasis syndrome arthrogryposis–renal dysfunction–cholestasis syndrome is a cutaneous condition caused by a mutation in the vps33b gene. most of the cases have been survived for infancy. recently, college of medical sciences in nepal reports a case of arc syndrome in a girl at the age of more than 18 years. arthrogryposis–renal dysfunction–cholestasis syndromeother namesarc syndromespecialtydermatology