naphthylpiperazine naphthylpiperazine 1-(1-naphthyl)piperazine (1-np) is a drug which is a phenylpiperazine derivative. it acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht1e, and 5-ht1f receptors, while antagonizing the 5-ht2a, 5-ht2b, and 5-ht2c receptors. it has also been shown to possess high affinity for the 5-ht3, 5-ht5a, 5-ht6, and 5-ht7 receptors, and may bind to 5-ht4 and the sert as well. in animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-ht2c receptor. naphthylpiperazineclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status in general: uncontrolled identifiers iupac name 1-(naphthalen-1-yl)piperazine cas number57536-86-4 ypubchem cid1342iuphar/bps3chemspider1302uniifj7mr37a24comptox dashboard (epa)dtxsid30973071 chemical and physical dataformulac14h16n2molar mass212.296 g·mol−13d model (jsmol)interactive image smiles c2cc(c1ccccc1c2)n3ccncc3