sh-053-r-ch3-2′f sh-053-r-ch3-2′f sh-053-r-ch3-2′f is a drug used in scientific research which is a benzodiazepine derivative. it produces some of the same effects as other benzodiazepines, but is much more subtype-selective than most other drugs of this class, having high selectivity, binding affinity and efficacy at the α5 subtype of the gabaa receptor. this gives much tighter control of the effects produced, and so while sh-053-r-ch3-2′f retains sedative and anxiolytic effects, it does not cause ataxia at moderate doses. sh-053-r-ch3-2′f also blocks the nootropic effects of the α5-selective inverse agonist pwz-029, so amnesia is also a likely side effect. sh-053-r-ch3-2′fidentifiers iupac name (r)-8-ethynyl-6-(2-fluorophenyl)-4-methyl-4h-2,5,10b-triaza-benzoazulene-3-carboxylic acid ethyl ester cas number872874-14-1pubchem cid11574585chemspider9749355chemical and physical dataformulac23h18fn3o2molar mass387.414 g·mol−13d model (jsmol)interactive image smiles fc2ccccc2c1=nc(c)c3c(c(=o)occ)ncn3-c(cc4)c1cc4c#c inchi inchi=1s/c23h18fn3o2/c1-4-15-10-11-19-17(12-15)20(16-8-6-7-9-18(16)24)26-14(3)22-21(23(28)29-5-2)25-13-27(19)22/h1,6-14h,5h2,2-3h3/t14-/m1/s1key:ngykelbmvxbfsm-cqszacivsa-n replacement of the ester function by an amide, realized in analogs such as mp-iii-022 and gl-ii-73, improves selectivity, efficacy, and kinetic behavior.