β-lgnd2 β-lgnd2 β-lgnd2, also known as erβ-selective ligand 2 or as gtx-878, is a synthetic nonsteroidal estrogen and selective erβ agonist which was under development by gtx for the treatment of benign prostatic hyperplasia, prostatitis, and rheumatoid arthritis but was never marketed. it shows approximately 25-fold selectivity for activation of the erβ over the erα (ec50 = 2 nm and 52 nm, respectively). β-lgnd2 is an isoquinolinone derivative. β-lgnd2clinical dataother namesβ-lgnd2; er-β-selective ligand 2drug classnonsteroidal estrogen; selective erβ agonistidentifiers iupac name 4-bromo-6,8-dihydroxy-2-(4-hydroxyphenyl)isoquinolin-1-one cas number1462971-30-7 1644567-26-9pubchem cid24962206chemical and physical dataformulac15h10brno4molar mass348.152 g·mol−13d model (jsmol)interactive image smiles c1=cc(=cc=c1n2c=c(c3=cc(=cc(=c3c2=o)o)o)br)o inchi inchi=1s/c15h10brno4/c16-12-7-17(8-1-3-9(18)4-2-8)15(21)14-11(12)5-10(19)6-13(14)20/h1-7,18-20hkey:glvqmsccfogrrg-uhfffaoysa-n