15β-hydroxycyproterone acetate 15β-hydroxycyproterone acetate 15β-hydroxycyproterone acetate (15β-oh-cpa) is a steroidal antiandrogen and the major metabolite of cyproterone acetate (cpa). it is formed from cpa in the liver by hydroxylation via the cytochrome p450 enzyme cyp3a4. during therapy with cpa, 15β-oh-cpa circulates at concentrations that are approximately twice those of cpa. 15β-oh-cpa has similar or even greater antiandrogen activity compared to cpa. however, it has only about one-tenth of the activity of cpa as a progestogen. 15β-oh-cpa also shows some glucocorticoid activity, similarly to cpa and unesterified cyproterone. 15β-hydroxycyproterone acetateclinical dataother names15β-hydroxy-cpa; 15β-oh-cpa; 6-chloro-15β,17α-dihydroxy-1α,2α-methylenepregna-4,6-diene-3,20-dione 17α-acetate; 6-chloro-1,2α-methylene-15β,17α-dihydroxy-δ6-progesterone 17α-acetateidentifiers iupac name (1r,3as,3br,8bs,8cs,10as)-1-acetyl-5-chloro-3-hydroxy-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopentacyclopropaphenanthren-1-yl acetate cas number65423-26-9 y 114884-50-3 (non-specific stereochemistry)pubchem cid10025840chemspider170395unii54af4jyt3fchemical and physical dataformulac24h29clo5molar mass432.94 g·mol−13d model (jsmol)interactive image smiles cc(=o)1(cc(21(cc32c=c(c4=cc(=o)5c534c)cl)c)o)oc(=o)c inchi inchi=1s/c24h29clo5/c1-11(26)24(30-12(2)27)10-20(29)21-14-8-18(25)17-9-19(28)13-7-16(13)23(17,4)15(14)5-6-22(21,24)3/h8-9,13-16,20-21,29h,5-7,10h2,1-4h3/t13-,14-,15+,16+,20?,21-,22+,23+,24+/m1/s1key:hranprdgaboknq-xhlvmsdxsa-n