morpheridine morpheridine morpheridine (morpholinoethylnorpethidine) is a 4-phenylpiperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine). it is a strong analgesic with around 4 times the potency of pethidine, and unlike pethidine, does not cause convulsions, although it produces the standard opioid side effects such as sedation and respiratory depression. morpheridineclinical dataatc codenonelegal statuslegal status au: s9 (prohibited substance) ca: schedule i de: anlage i (authorized scientific use only) uk: controlled drug us: schedule i un: psychotropic schedule i identifiers iupac name ethyl 1-(2-morpholin-4-ylethyl)-4-phenyl-piperidine-4-carboxylate cas number469-81-8 ypubchem cid61121chemspider55069 yunii1854gkb41ycomptox dashboard (epa)dtxsid20196979 echa infocard100.006.749 chemical and physical dataformulac20h30n2o3molar mass346.471 g·mol−13d model (jsmol)interactive image smiles o=c(occ)c3(c1ccccc1)ccn(ccn2ccocc2)cc3 inchi inchi=1s/c20h30n2o3/c1-2-25-19(23)20(18-6-4-3-5-7-18)8-10-21(11-9-20)12-13-22-14-16-24-17-15-22/h3-7h,2,8-17h2,1h3 ykey:jdedmckqpkgsax-uhfffaoysa-n y (verify) morpheridine is not currently used in medicine and is a schedule i drug which is controlled under un drug conventions. synthesis normeperidine synthesis: the key intermediate, normeperidine, is obtained by a scheme closely akin to the parent molecule. thus, alkylation of benzyl cyanide (1) with the tosyl analog of the bischloroethylamine (2) leads to the substituted piperidine (3). basic hydrolysis serves to convert the nitrile to the acid (4). treatment of this last with sulfuric acid in ethanol serves both to esterify the acid and to remove the tosyl group to yield the secondary amine (5). alkylation of that amine by means of n-(2-chloroethyl)morpholine gives morpheridine.