rosterolone rosterolone rosterolone (inn) (developmental code name sh-434), also known as 17α-propylmesterolone or 1α-methyl-17α-propyl-5α-androstan-17β-ol-3-one, is a steroidal antiandrogen which was first described in 1984 and was developed for topical administration but was never marketed. it has shown some efficacy in the treatment of acne, and lacks systemic effects with either topical or systemic administration. rosterolone is a derivative of mesterolone, which, in contrast, is an androgen and anabolic steroid. rosteroloneclinical dataother namessh-434; 17α-propylmesterolone; 17β-hydroxy-1α-methyl-17α-propyl-5α-androstan-3-oneroutes ofadministrationtopicalidentifiers iupac name (1s,5s,8r,9s,10s,13s,14s,17s)-17-hydroxy-1,10,13-trimethyl-17-propyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1h-cyclopentaphenanthren-3-one cas number79243-67-7pubchem cid71232chemspider64367unii3l5c5c8zngchemblchembl2107498echa infocard100.071.904 chemical and physical dataformulac23h38o2molar mass346.555 g·mol−13d model (jsmol)interactive image smiles cccc1(ccc2c1(ccc3c2ccc4c3(c(cc(=o)c4)c)c)c)o inchi inchi=1s/c23h38o2/c1-5-10-23(25)12-9-19-18-7-6-16-14-17(24)13-15(2)22(16,4)20(18)8-11-21(19,23)3/h15-16,18-20,25h,5-14h2,1-4h3/t15-,16-,18-,19-,20-,21-,22-,23-/m0/s1key:imfnbomnwhwkqd-mxensaddsa-n