interferon-induced transmembrane protein 5 interferon-induced transmembrane protein 5 interferon-induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization. ifitm5identifiersaliasesifitm5, interferon induced transmembrane protein 5, bril, dspa1, hrmp1, oi5, fragilis4external idsomim: 614757 mgi: 1934923 homologene: 14210 genecards: ifitm5 gene location (human)chr.chromosome 11 (human)band11p15.5start298,200 bpend299,526 bpgene location (mouse)chr.chromosome 7 (mouse)band7|7 f5start140,528,871 bpend140,530,204 bprna expression patternbgeehumanmouse (ortholog)top expressed inbody of pancreasbloodbone marrowgastric mucosaright lungright coronary arteryupper lobe of left lungright lobe of liverthyroid glandspleentop expressed incalvariabody of femurmolarfossaanklecondylemorulacochlealeft ventriclelipmore reference expression databiogpsn/aorthologsspecieshumanmouseentrez38773373835ensemblensg00000206013ensmusg00000025489uniprota6nnb3o88728refseq (mrna)nm_001025295nm_053088refseq (protein)np_001020466np_444318location (ucsc)chr 11: 0.3 – 0.3 mbchr 7: 140.53 – 140.53 mbpubmed searchwikidataview/edit humanview/edit mouse genomics the gene is located on the short arm of the crick strand of chromosome 11 (11p15.5). it is located with a cluster of interferon inducible genes but is itself not interferon inducible. the gene is 1,327 bases in length and encodes a protein of 132 amino acids with a predicted molecular weight of 14378 daltons. expression in adults is bone specific and highest in osteoblasts. the homolog in the mouse is located on chromosome 7. a homolog is also known to be present in lizards. evolution the gene first appeared in bony fish and its bone specific expression appears to be limited to therian mammals. biochemistry the protein has two transmembrane domains. it associates with fk506 binding protein 11. clinical mutations in the gene are associated with osteogenesis imperfecta type 5.