b-cell leukemia b-cell leukemia a b-cell leukemia is any of several types of lymphoid leukemia which affect b cells. b-cell leukemiaspecialtyhematology, oncology types include (with icd-o code): 9823/3 - b-cell chronic lymphocytic leukemia/small lymphocytic lymphoma 9826/3 - acute lymphoblastic leukemia, mature b-cell type 9833/3 - b-cell prolymphocytic leukemia 9835/3-9836/3 - precursor b lymphoblastic leukemia 9940/3 - hairy cell leukemia