alfuzosin alfuzosin alfuzosin, sold under the brand name uroxatral among others, is a medication of the α1 blocker class. it is used to treat benign prostatic hyperplasia (bph). alfuzosinclinical datapronunciation/ælˈfjuːzoʊsɪn/ al-few-zoh-sin trade namesuroxatral, othersahfs/drugs.commonographmedlineplusa64002license data us dailymed: alfuzosin pregnancycategory au: b2 routes ofadministrationby mouthatc codeg04ca01 (who) legal statuslegal status uk: pom (prescription only) us: ℞-only pharmacokinetic databioavailability49%protein binding82–90%metabolismliver (cyp3a4-mediated)elimination half-life10 hoursexcretionfeces (69%) and urine (24%)identifiers iupac name (rs)-n-propyl] tetrahydrofuran- 2-carboxamide cas number81403-80-7 ypubchem cid2092iuphar/bps7109drugbankdb00346 ychemspider2008 yunii90347ytw5fkeggd07124 ychebichebi:51141 ychemblchembl709 ycomptox dashboard (epa)dtxsid6048549 echa infocard100.108.671 chemical and physical dataformulac19h27n5o4molar mass389.456 g·mol−13d model (jsmol)interactive image smiles o=c(ncccn(c2nc1cc(oc)c(oc)cc1c(n2)n)c)c3occc3 inchi inchi=1s/c19h27n5o4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14h,4-9h2,1-3h3,(h,21,25)(h2,20,22,23) ykey:wnmjykcgwzffkr-uhfffaoysa-n y (verify) as an antagonist of the α1 adrenergic receptor, it works by relaxing the muscles in the prostate and bladder neck, making urination easier. alfuzosin was patented in 1978 and approved for medical use in 1988. it was approved in the us for benign prostatic hyperplasia in 2003. in 2020, it was the 336th-most commonly prescribed medication in the united states, with more than 700 thousand prescriptions. side effects the most common side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, fatigue, and abdominal disturbances. side effects include stomach pain, heartburn, and congested nose. adverse effects of alfuzosin are similar to that of tamsulosin but with 70% lower rate of retrograde ejaculation. chemistry alfuzosin contains a stereocenter, so is chiral, with two enantiomeric forms, (r)- and (s)-alfuzosin. the drug is used as a racemate, (rs)-alfuzosin, a 1:1 mixture of the (r)- and (s)- forms. enantiomers of alfuzosin cas number: 123739-69-5 cas number.: 123739-70-8 it is provided as the hydrochloride salt. society and culture brand names it is sold under the brand names alfosoft, uroxatral, xatral, prostetrol, and alfural..