eggerthellaceae eggerthellaceae the eggerthellaceae are a family of gram-positive, rod- or coccus-shaped actinomycetota. it is the sole family within the order eggerthellales. eggerthellaceae scientific classification domain: bacteria phylum: actinomycetota class: coriobacteriia order: eggerthellalesgupta et al. 2013 family: eggerthellaceaegupta et al. 2013 genera adlercreutzia maruo et al. 2008 "arabia" traore et al. 2017 asaccharobacter minamida et al. 2008 cryptobacterium nakazawa et al. 1999 denitrobacterium anderson et al. 2000 eggerthella kageyama et al. 1999 ellagibacter beltrán et al. 2018 enteroscipio danylec et al. 2018 gordonibacter würdemann et al. 2009 "hugonella" elsawi et al. 2017 paraeggerthella würdemann et al. 2009 parvibacter clavel et al. 2013 "phoenicibacter" bilen et al. 2017 "raoultibacter" traore et al. 2016 rubneribacter danylec et al. 2018 senegalimassilia corrig. lagier et al. 2014 slackia wade et al. 1999 the name eggerthellaceae is derived from the latin term eggerthella, referring to the type genus of the family and the suffix "-ceae," an ending used to denote a family. together, eggerthellaceae refers to a family whose nomenclatural type is the genus eggerthella. biochemical characteristics and molecular signatures members of this family are mostly anaerobic, non-motile (with the exception of some gordonibacter and senegalimassilia species that exhibit motility), asaccharolytic and do not form spores. eggerthellaceae species are commonly isolated from human and animal faeces and other human sources such as the colon, vagina, oral cavity and blood. some species have also been isolated from human samples of periodontal or endodontic infections, crohn's disease and severe blood bacteremia. the g+c content for eggerthellaceae species is between 43.4 and 66.3 mol%. analysis of genome sequences identified 13 conserved signature indels (csis) in diverse proteins that are exclusively present in different eggerthellaceae species. the proteins containing these csis are: contaexcinuclease abc subunit uvrc, dna polymerase iii subunit alpha, ribonuclease iii, trna (n6-isopentenyl adenosine(37)-c2)-methylthiotransferase (miab), peptide chain release factor 2, 16s rrna (cytosine(1402)-n(4))-methyltransferase, elongation factor tu, udp-n-acetylglucosamine 1-carboxyvinyltransferase dna polymerase iii subunit epsilon, udp-glucose 4-epimerase and dna-directed rna polymerase subunit alpha. the identified csis provide reliable and important means to distinguish members of eggerthellaceae from all other coriobacteriia as well as other bacteria. phylogeny a phylogenetic tree showing the taxonomic relationships within the family eggerthellaceae. a number of conserved signature indels were identified for the family as well as the genus aldercreutzia and their specificity is marked on the tree. this diagram is based on the bergery's entry for eggerthellaceae by gupta in 2021. the currently accepted taxonomy is based on the list of prokaryotic names with standing in nomenclature (lpsn). the phylogeny is based on whole-genome analysis. see figure for a detailed phylogenetic tree. eggerthellales slackia cryptobacterium denitrobacterium senegalimassilia eggerthella gordonibacter adlercreutzia outgroup coriobacteriales notes asaccharobacter, ellagibacter, enteroscipio, paraeggerthella, and rubneribacter are not included in this phylogenetic tree.