pf-05105679 pf-05105679 pf-05105679 is a drug which acts as a potent and selective blocker of the trpm8 ion channel, which is the main receptor responsible for the sensation of cold. it was developed as a potential analgesic, and blocks the sensation of cold in both animals and human trials. it also lowers core body temperature in small mammals, but does not produce this effect in humans in the normal dosage range. pf-05105679identifiers iupac name 3-(methyl)benzoic acid cas number1398583-31-7pubchem cid60195662drugbankdb15450chemspider57871141uniif2b10ofv7ychemblchembl3577885chemical and physical dataformulac26h21fn2o3molar mass428.463 g·mol−13d model (jsmol)interactive image smiles c(c1=cc=c(c=c1)f)n(cc2=cc(=cc=c2)c(=o)o)c(=o)c3=cc4=cc=cc=c4n=c3 inchi inchi=1s/c26h21fn2o3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17h,16h2,1h3,(h,31,32)/t17-/m1/s1key:bxnmzrptqfvrfa-qgzvfwflsa-n