middle cardiac nerve middle cardiac nerve the middle cardiac nerve (great cardiac nerve), the largest of the three cardiac nerves, arises from the middle cervical ganglion, or from the trunk between the middle and inferior ganglia. middle cardiac nervediagram of the cervical sympathetic.detailsfrommiddle cervical ganglionidentifierslatinnervus cardiacus cervicalis mediusanatomical terms of neuroanatomy on the right side it descends behind the common carotid artery, and at the root of the neck runs either in front of or behind the subclavian artery; it then descends on the trachea, receives a few filaments from the recurrent nerve, and joins the right half of the deep part of the cardiac plexus. in the neck, it communicates with the superior cardiac and recurrent nerves. on the left side, the middle cardiac nerve enters the chest between the left carotid and the left subclavian artery, and joins the left half of the deep part of the cardiac plexus.