the development of numerous tumors. cerebellar white matter and dentate nucleus lesions usually occur in children less than ten years of age. langerhans cell histiocytosis (lch): lch is an aggressive disorder due to proliferation of langerhans cell hystiocytes, and the dentate nucleus is believed to be involved in up to 40 percent of patients. alzheimer's disease (ad) with myoclonus: there is an increase in mean volume of large neurons and a decrease in mean volume of small neurons in the dentate nucleus in ad with myoclonus. morphological changes in the dentate nucleus may contribute to the pathological substrate of myoclonus in ad. additional images dissection of brain-stem. lateral view. deep dissection of brain-stem. lateral view. deep dissection of brain-stem. lateral view. rhomboid fossa.