dimetacrine dimetacrine dimetacrine (brand names istonil, istonyl, linostil, miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (tca) used in europe and formerly in japan for the treatment of depression. it has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests. little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other tcas. if this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants). dimetacrineclinical datatrade namesistonil, istonyl, linostil, miroistonilroutes ofadministrationoralatc coden06aa18 (who) legal statuslegal status in general: ℞ (prescription only) identifiers iupac name 3-(9,9-dimethylacridin-10-yl)-n,n-dimethyl-propan-1-amine cas number4757-55-5pubchem cid94280drugbankdb08996 ychemspider85085uniio341ny501nkeggd02565comptox dashboard (epa)dtxsid4022941 chemical and physical dataformulac20h26n2molar mass294.442 g·mol−13d model (jsmol)interactive image smiles cc1(c2=cc=cc=c2n(c3=cc=cc=c31)cccn(c)c)c