amg-333 amg-333 amg-333 is a drug which acts as a potent and selective blocker of the trpm8 ion channel, which is the main receptor responsible for the sensation of cold. it was developed as a potential treatment for migraine. amg-333identifiers iupac name 6-pyridine-3-carboxylic acid cas number1416799-28-4 ypubchem cid71144018chemspider72380128uniifr70864511chemblchembl4241349chemical and physical dataformulac20h12f5n3o4molar mass453.325 g·mol−13d model (jsmol)interactive image smiles c1=cc(=c(n=c1)(c2=cc(=c(c=c2)oc(f)(f)f)f)nc(=o)c3=nc=c(c=c3)c(=o)o)f inchi inchi=1s/c20h12f5n3o4/c21-12-2-1-7-26-17(12)16(10-4-6-15(13(22)8-10)32-20(23,24)25)28-18(29)14-5-3-11(9-27-14)19(30)31/h1-9,16h,(h,28,29)(h,30,31)/t16-/m0/s1key:qebyiswymfixoz-inizcteosa-n