or not is an issue pertaining to perception by users (commercial dealers and consumers at large), so even if a label has been regarded as a common name within a certain period, it may later come to be perceived as denoting a specific product as a matter of the ongoing real situation of its commerce, and it is not impossible for it to regain its source designator (出所表示機, shussho hyōji kinō) (i.e., manufacturer specifying) purpose". misinformed drug risk accusation controversy the primary active ingredient used in seirogan is wood-tar creosote. this was listed merely as "creosote" in the first edition of the japanese pharmacopoeia (日本薬局方, nihon yakkyokuhō), a ministry of health issued guidebook, and remained so for a time, until it was listed more specifically as moku-kureosōto (木クレオソート, "wood creosote") in the fifteenth revised first supplement dated 2007, making this the official name. in addition, "a long-term safety study in rats documented a lack of oncogenicity for wood creosote" the second supplement then defined the coal-derivative kureosōto-yu (クレオソート油, "creosote oil") as a separate commodity (containing carcinogenic substances such as benzo(a)pyrene, a polycyclic aromatic hydrocarbon). the wood-tar creosote is commonly called "nikkyoku creosote" (i.e. japanese pharmacopoeial creosote) as a means to distinguish from potentially harmful industrial creosote. these recent naming conventions were prompted by a controversy set off by a consumer alert booklet, katte wa ikenai (買ってはいけない, "should not buy") (pub. 1999) that anthologized a series run in the magazine shūkan kin'yōbi. the booklet accused seirogan of its dangers, based on the mistaken notion that the wood-tar creosote and the industrial creosote oil were identical commodities. notes ahmad i, aqil f, owais m (2007). modern phytomedicine: turning medicinal plants into drugs. john wiley & sons. p. 265. isbn 9783527609536. nishioka 2010, pp. 131-; discusses bugle as only recognized trademark; mentions a site that collected 26 different similar looking seirogan brand boxes; on p. 134 is a gallery of 20 different such boxes. matsumoto (松本有右); 渡辺謹三,三溝和男 (2011). 正露丸に次ぐ成長の柱「クレベリン」で世界を目指す大幸薬品の勝算. inside enterprise; shukan diamond (online). 秀和システム. p. 166. isbn 9784798030708... 整腸薬・下痢止めの成分比較表 "re: 週刊金曜日『買ってはいけない』特集より（８月２０日号）【正露丸、ラウンドアップ、マクドナルドハンバーガー】その３". ★阿修羅♪ ψ空耳の丘ψ３. 19 september 1999. archived from the original on 2004-03-19. retrieved 23 april 2014.. the retraction was in the magazine shūkan kin'yōbi issue 8/20/1999, special on katte wa ikenai; excerpt:"正露丸を「漢方薬」としましたが、漢方薬の成分である生薬は使われているものの、厳密には「漢方薬」ではありません。... 正露丸に使われているクレオソートはコールタールを原料とする日本工業規格クレオソート油ではなく、プナの木などから得られる乾留物を精製・蒸留して作る日本薬局方クレオソートでした。...(「回答企業にお応えします」より) suehiro i, kenkyūjo s (1974). "hōritsu jihō" (snippet). hōritsu jihō. nihon hyōronsha. retrieved 23 april 2014. 判決によると「正露丸」の名で丸薬を指定商品として商品登録していたのは大阪府吹田市内本町、大幸薬品。二十九年に特許庁で認められたため「正露丸」を製造していた約三十社は「正露丸」の名前を使えなくなった。これに対し大阪府和泉市芦部町、和泉薬品工業.. kyokuto (2006). "ゆうたんマークのご紹介". kyokuto website. archived from the original on 2008-04-25. retrieved 23 april 2014., says the mascot name yūtan is a pun on yūtan (熊胆, "bear's gall bladder") 虫歯の齲窩に直接詰めて使用するが、歯髄が壊死することによって痛みが治まるだけであり、根本的な治療にはならない。また、そのまま放置すると感染が根尖部に広がり、悪化してしまう。(used by directly stuffing in cavity, but only mitigates pain by causing necrosis of the pulp, and is not treatment that effects fundamental cure. if left otherwise untreated, infection can spread to the roots and worsen the condition) machida, shinobu (町田忍), macarthur and seirogan (「マッカーサーと正露丸」) gold h (2004). unit 731: testimony. tuttle publishing. isbn 9780804835657., p.21-22 nagai s, izumi t (2009). 生きつづけるということ: 文学にみる病いと老い (snippet). vol. 2. メディカルレビュー社. isbn 9784779203824., quote:"「正露丸」は当初、一九〇二年、中島住一によつて「任露丸(露西亜を任伐するの意)」の商品名によつて製造発売されたが、一九四六年大幸薬品が製造発売するようになり、一九四九年「正露丸」と名称変更" braina (2005-11-26). "大幸薬品、ひょうたんマーク「正露丸」販売の和泉薬品を提訴". 知財情報局(braina). retrieved 23 april 2014. wada n (2006). "判例13 「正露丸」事件（有名商標の普通名称化）". kizuna international patent office. retrieved 23 april 2014. braina (2006-07-28). "ラッパとひょうたんで識別可能、正露丸訴訟で大幸薬品の請求棄却". 知財情報局(braina). retrieved 23 april 2014. 平成１８年７月２７日判決言渡 平成１７年(ワ)第１１６６３号不正競争行為差止等請求事件 (text of the osaka court's opinion) kyodo news (共同通信) (2008-07-04). "大幸薬品の敗訴確定 「正露丸」混同せず". 47 news. retrieved 23 april 2014. japanese ministry of health bulletin no. 316, dated 9/28/2007 kuge t, shibata t, willett ms, turck p, traul ka (2001). "lack of oncogenicity of wood creosote, the principal active ingredient of seirogan, an herbal antidiarrheal medication, in sprague-dawley rats". international journal of toxicology. 20 (5): 297–305. doi:10.1080/109158101753253036. pmid 11766127. s2cid 26988810. us dept. of health and human services 1996 harvnb error: no target: citerefus_dept._of_health_and_human_services1996 (help) notes a study by weiner that found incidence of cancer highest in toyama prefecture where a manufacturer of seirogan was located, but cautions this cannot be ascertained to be a correlating factor. besides, toyama is not the prefecture where the major manufacturer is headquartered.