ca77.1 ca77.1 ca77.1 (ca) is a synthetic compound that activates chaperone-mediated autophagy (cma) by increasing the expression of the lysosomal receptor for this pathway, lamp2a, in lysosomes. ca77.1 is a derivative of earlier compound ar7, which shows potent cma activation in vitro but is not suitable for in vivo use. ca77.1 is able to activate cma in vivo, and demonstrates brain penetrance and favorable pharmacokinetics. it has been shown in animal studies that in vivo administration of ca77.1 to enhance chaperone-mediated autophagy, may help to degrade toxic pathogenic protein products such as tau proteins and has potential applications in the treatment of alzheimer's disease. ca77.1identifiers iupac name n-acetamide pubchem cid146439211chemical and physical dataformulac16h12cln3omolar mass297.74 g·mol−13d model (jsmol)interactive image smiles cc(=o)nc1=cc=c(c=c1)c2=cn=c3c=c(c=cc3=n2)cl inchi inchi=1s/c16h12cln3o/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9h,1h3,(h,19,21)key:zqxmpdvgbwotby-uhfffaoysa-n