nasofrontal vein nasofrontal vein the nasofrontal vein is a vein in the orbit around the eye. it drains into the superior ophthalmic vein. it can be used for endovascular access to the cavernous sinus. nasofrontal veinveins of orbit.detailsdrains tosuperior ophthalmic veinidentifierslatinvena nasofrontalista98a12.3.06.103ta24888fma51729anatomical terminology structure the nasofrontal vein drains into the superior ophthalmic vein. clinical significance the nasofrontal vein can be used to access the superior ophthalmic vein and the cavernous sinus with endovascular tools.