amtolmetin guacil amtolmetin guacil amtolmetin guacil is a non-steroidal anti-inflammatory drug (nsaid). it is a prodrug of tolmetin sodium. amtolmetin guacilclinical dataother namesst-679atc codenoneidentifiers iupac name (2-methoxyphenyl) 2-acetyl]ami cas number87344-06-7 npubchem cid65655chemspider59091 yunii323a00cro9keggd07453 ychemblchembl1766570 ncomptox dashboard (epa)dtxsid50236291 echa infocard100.207.038 chemical and physical dataformulac24h24n2o5molar mass420.465 g·mol−13d model (jsmol)interactive image smiles o=c(c1ccc(n1c)cc(=o)ncc(=o)oc2ccccc2oc)c3ccc(cc3)c inchi inchi=1s/c24h24n2o5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13h,14-15h2,1-3h3,(h,25,27) ykey:cwjnmkkmgiagdk-uhfffaoysa-n y ny (what is this?) (verify) background tolmetin sodium is an approved nsaid, marketed for the treatment of rheumatoid arthritis, osteoarthritis and juvenile rheumatoid arthritis. in humans, tolmetin sodium is absorbed rapidly with peak plasma levels observed 30 min after administration. it is eliminated rapidly with a mean plasma elimination t½ of approximately 1 hr. the preparation of slow release formulations or chemical modification of nsaids to form prodrugs has been suggested as a method to reduce the gastrotoxicity of these agents. amtolmetin guacil is a non-acidic prodrug of tolmetin, having nsaid properties similar to tolmetin with additional analgesic, antipyretic, and gastro protective properties. amtolmetin is formed by amidation of tolmetin by glycine. pharmacology most is absorbed on oral administration. it is concentrated in the gastric wall. highest concentration is reached 2 hours after administration. amtolmetin guacil can be hydrolysed to produce the metabolites tolmetin, med5 and guiacol. elimination completes in 24 hours. this happens mostly with urine in shape of gluconides products (77%), faecal (7.5%). it is advised to take the drug on empty stomach. permanent anti-inflammatory action continues up to 72 hours, with single administration. mechanism of action amtolmetin guacil stimulates capsaicin receptors present on gastrointestinal walls, because of presence of vanillic moiety and also releases no which is gastro protective. it also inhibits prostaglandin synthesis and cyclooxygenase (cox).