desmoplastic melanoma desmoplastic melanoma desmoplastic melanoma is a rare cutaneous condition characterized by a deeply infiltrating type of melanoma: 696 with an abundance of fibrous matrix. it usually occurs in the head and neck region of older people with sun-damaged skin. diagnosis can be difficult as it has a similar appearance to sclerosing melanocytic nevi as well as some nonmelanocytic skin lesions such as scars, fibromas, or cysts. desmoplastic melanomaother namesneurotropic melanoma, or spindled melanomadesmoplastic melanomaspecialtydermatology desmoplastic melanomas tend to recur locally, with distant metastasis being less common.