estriol glucuronide estriol glucuronide estriol glucuronide (e3g), or oestriol glucuronide, also known as estriol monoglucuronide, as well as estriol 16α-β-d-glucosiduronic acid, is a natural, steroidal estrogen and the glucuronic acid (β-d-glucopyranuronic acid) conjugate of estriol. it occurs in high concentrations in the urine of pregnant women as a reversibly formed metabolite of estriol. estriol glucuronide is a prodrug of estriol, and was the major component of progynon and emmenin, estrogenic products manufactured from the urine of pregnant women that were introduced in the 1920s and 1930s and were the first orally active estrogens. emmenin was succeeded by premarin (conjugated equine estrogens), which is sourced from the urine of pregnant mares and was introduced in 1941. premarin replaced emmenin due to the fact that it was easier and less expensive to produce. estriol glucuronideclinical dataother namesestriol glucuronidate; (16α,17β)-16,17-dihydroxyestra-1,3,5(10)-trien-3-yl d-glucopyranosiduronic acid; β-d-glucopyranuronic acid, monoglycoside with (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triolroutes ofadministrationby mouthidentifiers iupac name (2s,3s,4s,5r,6r)-6-phenanthren-16-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid cas number28808-07-3pubchem cid122281chemspider134818comptox dashboard (epa)dtxsid30939935 echa infocard100.161.795 chemical and physical dataformulac24h32o9molar mass464.511 g·mol−13d model (jsmol)interactive image smiles c12cc3(1c(2o)o4((((o4)c(=o)o)o)o)o)ccc5=c3c=cc(=c5)o inchi inchi=inchi=1s/c24h32o9/c1-24-7-6-13-12-5-3-11(25)8-10(12)2-4-14(13)15(24)9-16(21(24)29)32-23-19(28)17(26)18(27)20(33-23)22(30)31/h3,5,8,13-21,23,25-29h,2,4,6-7,9h2,1h3,(h,30,31)/t13-,14-,15+,16-,17+,18+,19-,20+,21+,23-,24+/m1/s1key:fqyggfdzjfidpu-jrsyhjkysa-n estrogen glucuronides can be deglucuronidated into the corresponding free estrogens by β-glucuronidase in tissues that express this enzyme, such as the mammary gland. as a result, estrogen glucuronides have estrogenic activity via conversion into estrogens. the positional isomer of estriol 16α-glucuronide, estriol 3-glucuronide, also occurs as an endogenous metabolite of estriol, although to a much lower extent in comparison.