tetrandrine tetrandrine tetrandrine, a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. it is isolated from the plant stephania tetrandra, and other chinese and japanese herbs. tetrandrine names iupac name 9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclohexatriaconta-3,5,8(34),9,11,18,20,22(33),24(32),25,27(31),35-dodecaene identifiers cas number 518-34-3 y 3d model (jsmol) interactive image chembl chembl176045 n echa infocard 100.208.615 kegg c09654 y pubchem cid 73078 unii 29ex23d5aj n comptox dashboard (epa) dtxsid10178062 smiles cn1ccc2=cc(=c3c=c2c1cc4=cc=c(c=c4)oc5=c(c=cc(=c5)cc6c7=c(o3)c(=c(c=c7ccn6c)oc)oc)oc)oc properties chemical formula c38h42n2o6 molar mass 622.74988 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references pharamacology it has anti-inflammatory, immunologic and antiallergenic effects. it inhibits the degranulation of mast cells. it has a quinidine-like anti-arrhythmic effect. it has vasodilatory properties and can therefore reduce blood pressure. tetrandrine may have potential use for the treatment of liver disease and liver cancer. tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation. tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. tetrandrine has also been shown to inhibit entry of ebola virus into host cells in vitro and showed therapeutic efficacy against ebola in preliminary studies on mice. tetrandrine has also been studied and patented as a possible treatment for tinnitus. biosynthesis tetrandrine is biosynthesized from a free radical coupled dimerization of s-n-methylcoclaurine: synonyms synonyms include fanchinine, hanfangchin a, nsc 77037, (s,s)-(+)-tetrandrine, sinomenine a, ttd, tetrandrin, d-tetrandrine, and gw-201.