liranaftate liranaftate liranaftate (trade name zefnart) is a topical antifungal drug. it is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). it was approved for use in japan in august 2000. liranaftateclinical datatrade nameszefnartother namesm-732; piritetrateroutes ofadministrationtopicalatc coded01ae25 (who) legal statuslegal status jp: rx-only identifiers iupac name o-(5,6,7,8-tetrahydronaphthalen-2-yl) n-(6-methoxypyridin-2-yl)-n-methylcarbamothioate cas number88678-31-3pubchem cid3936chemspider3799unii5253igo5x3keggd01550comptox dashboard (epa)dtxsid6046470 chemical and physical dataformulac18h20n2o2smolar mass328.43 g·mol−1 liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.