chloroprednisone chloroprednisone chloroprednisone is a topical glucocorticoid first reported in 1960. it is a chlorinated derivative of prednisone. the acetate ester prodrug, chloroprednisone 21-acetate, was sold under the brand name topilan as an anti-inflammatory agent. chloroprednisoneclinical dataother names6α-chloro-1,4-pregnadiene-17a,21-diol-3,11,20-trioneatc codes01ca09 (who) (combination with antiinfectives)identifiers iupac name (6α)-6-chloro-17,21-dihydroxypregna-1,4-diene-3,11,20-trione cas number52080-57-6pubchem cid3034026chemspider2298578unii564ibo56ipecha infocard100.052.387 chemical and physical dataformulac21h25clo5molar mass392.88 g·mol−13d model (jsmol)interactive image smiles o=c(co)3(o)cc24c(cl)\c1=c\c(=o)\c=c/1(c)4c(=o)c23c inchi inchi=1s/c21h25clo5/c1-19-5-3-11(24)7-14(19)15(22)8-12-13-4-6-21(27,17(26)10-23)20(13,2)9-16(25)18(12)19/h3,5,7,12-13,15,18,23,27h,4,6,8-10h2,1-2h3/t12-,13-,15-,18+,19-,20-,21-/m0/s1key:npslcowkffnqkk-zpsuvkrcsa-n there is little published about chloroprednisone. this may be due to limited activity topically because the skin lacks the necessary activating enzyme 11-beta hydroxysteroid dehydrogenase. systemically, this agent's activity on glucocorticoid receptors may not have competed with agents like fludrocortisone or dexamethasone.