serotonergic serotonergic serotonergic (/ˌsɛrətəˈnɜːrdʒɪk, ˌsɪər-/) or serotoninergic (/ˌsɪərətoʊnɪˈnɜːrdʒɪk/) means "pertaining to or affecting serotonin". serotonin is a neurotransmitter. a synapse is serotonergic if it uses serotonin as its neurotransmitter. a serotonergic neuron produces serotonin. a substance is serotonergic if it produces its effects via interactions with the serotonin system, such as by stimulating or blocking neurotransmission. a serotonergic or serotoninergic agent is any chemical that modifies the effects of serotonin in the body. some different types of serotonergics drugs include the following: serotonin receptor agonists and antagonists serotonin reuptake inhibitors serotonin releasing agents