erythema multiforme major erythema multiforme major erythema multiforme major is a form of rash with skin loss or epidermal detachment. erythema multiforme majusother nameserythema multiforme majusmicrograph of confluent epidermal necrosis. h&e stain.specialtydermatology the term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation. according to some sources, there are two conditions included on a spectrum of this same disease process: stevens–johnson syndrome (sjs) toxic epidermal necrolysis (ten) which described by alan lyell and previously called lyell syndrome. in this view, em major, sjs and ten are considered a single condition, distinguished by degree of epidermal detachment. however, a consensus classification separates erythema multiforme minor, erythema multiforme major, and sjs/ten as three separate entities.