estradiol distearate estradiol distearate estradiol distearate (eds), also known as estradiol dioctadecanoate, is an estrogen and an estrogen ester which was never marketed. it is a long-acting prodrug of estradiol in the body. structural properties of selected estradiol esters estrogenstructureester(s)relativemol. weightrelativee2 contentblog pc position(s)moiet(ies)typelengtha estradiol––––1.001.004.0 estradiol acetatec3ethanoic acidstraight-chain fatty acid21.150.874.2 estradiol benzoatec3benzenecarboxylic acidaromatic fatty acid– (~4–5)1.380.724.7 estradiol dipropionatec3, c17βpropanoic acid (×2)straight-chain fatty acid3 (×2)1.410.714.9 estradiol valeratec17βpentanoic acidstraight-chain fatty acid51.310.765.6–6.3 estradiol benzoate butyratec3, c17βbenzoic acid, butyric acidmixed fatty acid– (~6, 2)1.640.616.3 estradiol cypionatec17βcyclopentylpropanoic acidaromatic fatty acid– (~6)1.460.696.9 estradiol enanthatec17βheptanoic acidstraight-chain fatty acid71.410.716.7–7.3 estradiol dienanthatec3, c17βheptanoic acid (×2)straight-chain fatty acid7 (×2)1.820.558.1–10.4 estradiol undecylatec17βundecanoic acidstraight-chain fatty acid111.620.629.2–9.8 estradiol stearatec17βoctadecanoic acidstraight-chain fatty acid181.980.5112.2–12.4 estradiol distearatec3, c17βoctadecanoic acid (×2)straight-chain fatty acid18 (×2)2.960.3420.2 estradiol sulfatec3sulfuric acidwater-soluble conjugate–1.290.770.3–3.8 estradiol glucuronidec17βglucuronic acidwater-soluble conjugate–1.650.612.1–2.7 estramustine phosphatedc3, c17βnormustine, phosphoric acidwater-soluble conjugate–1.910.522.9–5.0 polyestradiol phosphateec3–c17βphosphoric acidwater-soluble conjugate–1.23f0.81f2.9g footnotes: a = length of ester in carbon atoms for straight-chain fatty acids or approximate length of ester in carbon atoms for aromatic fatty acids. b = relative estradiol content by weight (i.e., relative estrogenic exposure). c = experimental or predicted octanol/water partition coefficient (i.e., lipophilicity/hydrophobicity). retrieved from pubchem, chemspider, and drugbank. d = also known as estradiol normustine phosphate. e = polymer of estradiol phosphate (~13 repeat units). f = relative molecular weight or estradiol content per repeat unit. g = log p of repeat unit (i.e., estradiol phosphate). sources: see individual articles. estradiol distearateclinical dataother nameseds; estradiol 3,17β-distearate; estradiol dioctadecanoate; estra-1,3,5(10)-triene-3,17β-diol 3,17β-dioctadecanoateidentifiers iupac name phenanthren-17-yl] octadecanoate cas number126144-03-4 ypubchem cid53672832uniib8hem55ugkchemical and physical dataformulac54h92o4molar mass805.326 g·mol−13d model (jsmol)interactive image smiles cccccccccccccccccc(=o)o1cc21(cc32ccc4=c3c=cc(=c4)oc(=o)ccccccccccccccccc)c inchi inchi=1s/c54h92o4/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-52(55)57-46-37-39-47-45(44-46)36-38-49-48(47)42-43-54(3)50(49)40-41-51(54)58-53(56)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h37,39,44,48-51h,4-36,38,40-43h2,1-3h3/t48-,49-,50+,51+,54+/m1/s1key:bbbpctnbnyfuov-nxcwiaoisa-n