tacalcitol tacalcitol tacalcitol (1,24-dihydroxyvitamin d3) is a synthetic vitamin d3 analog. tacalcitol is marketed under several names, including curatoderm and bonalfa. tacalcitolclinical dataother names(1α,24r)-1,24-dihydroxyvitamin d3ahfs/drugs.cominternational drug namesroutes ofadministrationtopicalatc coded05ax04 (who) identifiers iupac name (1s,3r,5z,7e,24r)-9,10-secocholesta-5,7,10-triene-1,3,24-triol cas number57333-96-7 ypubchem cid5283734iuphar/bps2780chemspider4446823 nuniic2w72oj5zuchebichebi:32176chemblchembl340361 ncomptox dashboard (epa)dtxsid90905111 echa infocard100.220.855 chemical and physical dataformulac27h44o3molar mass416.64 g·mol−13d model (jsmol)interactive image smiles o1cc(\c(=c)(o)c1)=c\c=c2/ccc3(2cc3(c)cc(o)c(c)c)c inchi inchi=1s/c27h44o3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30h,4,6-8,11-16h2,1-3,5h3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 nkey:bjylyjcxyamoft-rsfvbtmbsa-n n ny (what is this?) (verify) it is on the world health organization's list of essential medicines. mechanism tacalcitol reduces excessive cell turnover in the epidermis by interacting with vitamin d receptors on keratinocytes. uses it is usually prescribed by a general practitioner or dermatologist for the treatment of psoriasis, chronic chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover. it is available as an ointment or lotion. it has also been used for vitiligo and hailey-hailey disease.