mandibular prominence mandibular prominence the mandibular prominence is an embryological structure which gives rise to the lower portion of the face. mandibular prominencedetailsprecursorfirst pharyngeal archgives rise tomandibleidentifierslatinprominentia mandibularisteprominence_by_e5.3.0.0.0.0.14 e5.3.0.0.0.0.14 anatomical terminology the mandible and lower lip derive from it. the mesenchymal cells within the mandibular prominence condense to form meckel's cartilage. it is innervated by the mandibular nerve.