naloxazone naloxazone naloxazone is an irreversible μ-opioid receptor antagonist which is selective for the μ1 receptor subtype. naloxazone produces very long lasting antagonist effects as it forms a covalent bond to the active site of the μ-opioid receptor, thus making it impossible for the molecule to unbind and blocking the receptor permanently until the receptor is recycled by endocytosis. not to be confused with naloxone. naloxazone names iupac name (5α)-17-allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrazone other names naloxone- 6-hydrazone identifiers cas number 73674-85-8 y 3d model (jsmol) interactive image chembl chembl354010 y pubchem cid 9576788 smiles c=ccn1ccc23c4c(=nn)ccc2(c1cc5=c3c(=c(c=c5)o)o4)o properties chemical formula c19h23n3o3 molar mass 341.40422 g/mol except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). y verify (what is yn ?) infobox references naloxazone is the hydrazone analog of naloxone. it has been reported that naloxazone is unstable in acidic solution, dimerizing into the more stable and much more potent antagonist naloxonazine via the free nh2 of the hydrazone to form an azine linkage. under conditions in which no naloxonazine formation could be detected, naloxazone did not display irreversible μ opioid receptor binding.