cefoperazone cefoperazone cefoperazone is a third-generation cephalosporin antibiotic, marketed by pfizer under the name cefobid. it is one of few cephalosporin antibiotics effective in treating pseudomonas bacterial infections which are otherwise resistant to these antibiotics. cefoperazoneclinical dataahfs/drugs.commicromedex detailed consumer informationmedlineplusa601206atc codej01dd12 (who) qj51dd12 (who)pharmacokinetic dataexcretionhepaticidentifiers iupac name (6r,7r)-7-amino}-2-(4-hydroxyphenyl)acetamido]-3--8-oxo-5-thia-1-azabicyclooct-2-ene-2-carboxylic acid cas number62893-19-0 ypubchem cid44185drugbankdb01329 ychemspider40206 yunii7u75i1278dkeggd07645 ychemblchembl507674 ycomptox dashboard (epa)dtxsid2022759 echa infocard100.057.936 chemical and physical dataformulac25h27n9o8s2molar mass645.67 g·mol−13d model (jsmol)interactive image smiles o=c2n1/c(=c(\cs12nc(=o)(c3ccc(o)cc3)nc(=o)n4c(=o)c(=o)n(cc)cc4)csc5nnnn5c)c(=o)o inchi inchi=1s/c25h27n9o8s2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35h,3,8-11h2,1-2h3,(h,26,36)(h,27,42)(h,40,41)/t15-,16-,22-/m1/s1 ykey:gcfbrxlshgkwdp-xcgnwrkasa-n y (verify) it was patented in 1974 and approved for medical use in 1981. cefoperazone/sulbactam (sulperazon) is a co-formulation with sulbactam. spectrum of bacterial susceptibility cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract. the following represents mic susceptibility data for a few medically significant microorganisms. haemophilus influenzae: 0.12 - 0.25 µg/ml staphylococcus aureus: 0.125 - 32 µg/ml streptococcus pneumoniae: ≤0.007 - 1 µg/ml adverse effects cefoperazone contains an n-methylthiotetrazole (nmtt or 1-mtt) side chain. as the antibiotic is broken down in the body, it releases free nmtt, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin k epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (antabuse), due to inhibition of aldehyde dehydrogenase. mechanism of action cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms.