coronaridine coronaridine coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in tabernanthe iboga and related species, including tabernaemontana divaricata for which (under the now obsolete synonym ervatamia coronaria) it was named. coronaridineclinical dataatc codenoneidentifiers iupac name methyl (1s,15r,17s,18s)-17-ethyl-3,13-diazapentacyclononadeca-2(10),4,6,8-tetraene-1-carboxylate cas number467-77-6pubchem cid6426909chemspider4932328chebichebi:3887comptox dashboard (epa)dtxsid60963642 echa infocard100.006.727 chemical and physical dataformulac21h26n2o2molar mass338.451 g·mol−13d model (jsmol)interactive image smiles ccc1cc2cc3(c1n(c2)ccc4=c3nc5=cc=cc=c45)c(=o)oc inchi inchi=1s/c21h26n2o2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22h,3,8-12h2,1-2h3/t13-,14+,19+,21-/m1/s1key:nvvdqmvgalbdge-pzxgurogsa-n like ibogaine, (r)-coronaridine and (s)-coronaridine can decrease intake of cocaine and morphine intake in animals and it may have muscle relaxant and hypotensive activity. chemistry congeners coronaridine congers are important in drug discovery and development due to multiple actions on different targets. they have ability to inhibit cav2.2 channel, modulate and inhibit subunits of nachr selectively such as α9α10, α3β4 and potentiate gabaa activity. pharmacology coronaridine has been reported to bind to an assortment of molecular sites, including: μ-opioid (ki = 2.0 μm), δ-opioid (ki = 8.1 μm), and κ-opioid receptors (ki = 4.3 μm), nmda receptor (ki = 6.24 μm) (as an antagonist), and nachrs (as an antagonist). it has also been found to inhibit the enzyme acetylcholinesterase, act as a voltage-gated sodium channel blocker, and displays estrogenic activity in rodents. in contrast to ibogaine and other iboga alkaloids, coronaridine does not bind to either the σ1 or σ2 receptor. sources plant sources familyplants apocynaceaet. catharinensis, t. ternifolia, t. pandacaqui, t. heyneana, t. litoralis, t. divaricata, t. penduliflora.