proteus-like syndrome proteus-like syndrome proteus-like syndrome (pls) is a condition similar to proteus syndrome, but with an uncertain cause.it's characterized by skeletal and hamartous overgrowth of multiple tissues, nevi in cerebriform connective tissue, blood vessel malformations and linear epidermal nevi. proteus-like syndromespecialtymedical genetics it was featured aa the first story in the 7th episode of the 10th season of mystery diagnosis.