goblet cell carcinoid goblet cell carcinoid the goblet cell carcinoid (gcc) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from paneth cells. goblet cell carcinoidother namescrypt cell carcinoma, neuroendocrine tumour with goblet cell differentiationmicrograph showing a goblet cell carcinoid. h&e stain. sign and symptoms gccs may present as appendicitis. diagnosis micrograph of a goblet cell carcinoid. h&e stain. gccs are diagnosed by pathology. they have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin). prognosis gccs have an aggressive course compared to other appendiceal neuroendocrine tumours. treatment gccs are treated with surgery.