rimexolone rimexolone rimexolone is a glucocorticoid steroid used to treat inflammation in the eye. it is marketed as a 1% eye drop suspension under the trade name vexol by alcon laboratories, but was discontinued in the us and other countries. rimexoloneclinical datatrade namesvexolother namestrimexolone; org 6216; 11β-hydroxy-16α,17α,21-trimethylpregna-1,4-dien-3,20-dioneahfs/drugs.commonographmedlineplusa606003routes ofadministrationeye dropsatc codeh02ab12 (who) s01ba13 (who)pharmacokinetic dataelimination half-lifeestimated 1–2 hoursexcretion>80% faecesidentifiers iupac name (8s,9s,10r,11s,13s,14s,16r,17s)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopentaphenanthren-3-one cas number49697-38-3 ypubchem cid5311412iuphar/bps7099drugbankdb00896 ychemspider4470902 nuniio7m2e4264dkeggd05729 ychemblchembl1200617 ncomptox dashboard (epa)dtxsid4045474 echa infocard100.211.227 chemical and physical dataformulac24h34o3molar mass370.533 g·mol−13d model (jsmol)interactive image smiles ccc(=o)1((c21(c(32ccc4=cc(=o)c=c34c)o)c)c)c inchi inchi=1s/c24h34o3/c1-6-20(27)24(5)14(2)11-18-17-8-7-15-12-16(25)9-10-22(15,3)21(17)19(26)13-23(18,24)4/h9-10,12,14,17-19,21,26h,6-8,11,13h2,1-5h3/t14-,17+,18+,19+,21-,22+,23+,24-/m1/s1 nkey:qttrzhgpgkrafb-ookhyknysa-n n ny (what is this?) (verify) medical uses rimexolone is used to treat inflammation after eye surgery, to treat anterior uveitis, conjunctivitis and keratitis. contraindications the substance is contraindicated in herpes simplex and most other viral eye infections, as well as mycobacterial, fungal and amoebal eye infections because it only reduces the inflammation but does not act against such microorganisms. side effects the most common adverse effects are blurred vision, tearing and other kinds of eye discomfort. eye pain, eye oedema, headache, increased intraocular pressure and other side effects are seen in less than 1% of patients. pharmacology pharmacodynamics further information: glucocorticoid § mechanism of action as a glucocorticoid, rimexolone acts as an agonist of the glucocorticoid receptor. pharmacokinetics a small amount of rimexolone is absorbed into the systemic circulation. on hourly treatment with the eye drops for a week, blood serum concentrations peaked at 150 pg/ml on average, with many patients remaining below the detection threshold of 80 pg/ml. the elimination half-life from the circulation is estimated at one to two hours; the substance is mainly (over 80%) excreted via the faeces.