organification organification organification is a biochemical process that takes place in thyroid gland. it is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (tpo). since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine". thionamides can block organification.