nucleus prepositus nucleus prepositus the nucleus prepositus (also nucleus prepositus hypoglossi), located in the caudal pons and upper medulla oblongata, contributes to several aspects of gaze control including the horizontal gaze holding system. it functions as a neural integrator. a cross section of the lower pons showing the nucleus prepositus (#5) labeled at the top left. nucleus prepositusdetailsidentifierslatinnucleus prepositus hypoglossineurolex idbirnlex_2652anatomical terms of neuroanatomy