kahrp kahrp kahrp (knob-associated histidine-rich protein) is a protein expressed by plasmodium falciparum infecting erythrocytes. kahrp is a major component of knobs, feature found on plasmodium falciparum infected erythrocytes. knob-associated histidine-rich proteinidentifiersorganismplasmodium falciparumsymbol?uniprotp09346search forstructuresswiss-modeldomainsinterpro emp3-kahrp-like n-terminal domainidentifierssymbolekalpfampf17986interproipr040805available protein structures:pfam structures / ecod pdbrcsb pdb; pdbe; pdbjpdbsumstructure summaryemp3 refers to "erythrocyte membrane protein 3." it is likely a misnomer, as no reported pfemp3 sequences contain this domain. pfemp3 is arranged next to kahrp in the p. falciparum genome, a probable cause of misidentification. it has been suggested that kahrp may play a role in trafficking or docking pfemp1, major malarial cytoadherence protein to the erythrocyte membrane; however, these findings were disputed by recent nmr and fluorescence anisotropy studies showing no interaction between pfemp1 and kahrp. instead, kahrp was shown to interact with ankyrin, more precisely the d3 subunit of the membrane-binding domain of ankyrin type 1. this interaction was suggested via spr, elisa, and pulldown studies, however, it has not been confirmed by nmr, itc, crystallography, or fluorescence anisotropy.