tampramine tampramine tampramine (ahr-9,377) is a tricyclic antidepressant (tca) which was developed in the 1980s but was never marketed. despite being a tca, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors. it was found to be effective in the forced swim test (fst) model of depression in animal studies but is not known to have ever been trialed in humans. tampramineclinical dataroutes ofadministrationorallegal statuslegal status in general: uncontrolled identifiers iupac name n,n-dimethyl-3-(6-phenylpyridobenzodiazepin-11-yl)propan-1-amine cas number83166-17-0 83166-18-1 (fumarate)pubchem cid54961chemspider49631unii47gse5rm8ncomptox dashboard (epa)dtxsid00232203 chemical and physical dataformulac23h24n4molar mass356.473 g·mol−13d model (jsmol)interactive image smiles cn(c)cccn1c2ccccc2c(=nc3c1nccc3)c4ccccc4