etazolate etazolate etazolate (sq-20,009, eht-0202) is an anxiolytic drug which is a pyrazolopyridine derivative and has unique pharmacological properties. it acts as a positive allosteric modulator of the gabaa receptor at the barbiturate binding site, as an adenosine antagonist of the a1 and a2 subtypes, and as a phosphodiesterase inhibitor selective for the pde4 isoform. it is currently in clinical trials for the treatment of alzheimer's disease. etazolateclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status in general: uncontrolled identifiers iupac name ethyl 1-ethyl-4--1h-pyrazolopyridine-5-carboxylate cas number51022-77-6pubchem cid3277iuphar/bps7336chemspider3162uniii89y79062lchebichebi:138502chemblchembl356388comptox dashboard (epa)dtxsid4048434 chemical and physical dataformulac14h19n5o2molar mass289.339 g·mol−13d model (jsmol)interactive image smiles ccn1c2=nc=c(c(=c2c=n1)nn=c(c)c)c(=o)occ inchi inchi=1s/c14h19n5o2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8h,5-6h2,1-4h3,(h,15,18)key:opqrbxubwhdhpq-uhfffaoysa-n synthesis cartazolate and etazolate synthesis