stanozolol36 1-testosterone98 testosterone82 testosterone benzoate8 testosterone cypionate6 testosterone enanthate9 δ4-tibolone8 trestolone12 trestolone enanthate12 vinyltestosterone36 values are rbas (%). the reference ligand (100%) for shbg was dihydrotestosterone. affinities of 11 steroids for shbg and cbg compoundshbg (%)cbg (%) aldosterone<0.26.0 corticosterone<0.2107 cortisol<0.2100 dexamethasone<0.2<0.1 dihydrotestosterone1000.8 estradiol8.7<0.1 metribolone0.2<0.1 moxestrol<0.2<0.1 progesterone<0.225 promegestone<0.20.9 testosterone263 values are rbas (%). the reference ligand (100%) for shbg was dihydrotestosterone and for cbg was cortisol. affinities of 9 estrogens for shbg compoundrba toshbg (%)bound toshbg (%)bound toalbumin (%) 17β-estradiol503761 estrone121680 estriol0.3191 estrone sulfate0099 17β-dihydroequilin30 ? ? equilin82613 17β-dihydroequilin sulfate0 ? ? equilin sulfate0 ? ? δ8-estrone ? ? ? the reference ligand (100%) for the shbg rba (%) values was testosterone. endogenous steroids measurement when checking serum estradiol or testosterone, a total level that includes free and bound fractions can be assayed, or the free portion may be measured alone. sex hormone-binding globulin can be measured separately from the total fraction of testosterone. a free androgen index expresses the ratio of testosterone to shbg and can be used to summarize the activity of free testosterone. affinity and binding affinities of endogenous steroids for shbg and plasma protein binding steroidshbg affinityplasma protein binding in menplasma protein binding in women (follicular phase) rba (%)k (106 m−1)total (nm)unbound (%)shbg (%)cbg (%)albumin (%)total (nm)unbound (%)shbg (%)cbg (%)albumin (%) aldosterone0.0170.210.3537.10.1021.241.60.2436.80.2321.941.2 3α-androstanediol8213000.410.8513.7<0.185.50.0680.7127.9<0.171.4 androstenediol9715004.33.2460.4<0.136.32.41.7378.8<0.119.4 androstenedione2.3294.17.852.821.3788.05.47.546.631.3784.5 androsterone1.1142.04.220.730.5294.51.54.181.770.5493.5 corticosterone0.182.2123.390.0977.519.07.03.280.2278.118.4 cortisol0.131.64003.910.0889.56.574003.770.1889.76.33 cortisone0.222.77216.20.5438.045.35415.81.3038.644.3 dehydroepiandrosterone5.366244.133.38<0.192.4173.937.88<0.188.1 11-deoxycorticosterone1.9240.202.690.8036.460.10.122.621.9136.958.6 11-deoxycortisol1.3161.43.370.6777.118.90.603.241.5777.118.1 dihydrotestosterone22055001.70.8859.70.2239.20.650.4778.40.1221.0 estradiol496800.0842.3219.6<0.178.00.291.8137.3<0.160.8 estriol0.354.30.0378.150.44<0.291.30.108.101.06<0.290.7 estrone121500.0813.967.37<0.188.60.233.5816.3<0.180.1 etiocholanolone0.111.41.38.150.140.4491.31.28.130.350.4691.1 pregnenolone1.1142.42.870.500.1696.52.22.851.210.1695.8 17α-hydroxypregnenolone0.192.35.44.270.12<0.195.53.54.260.30<0.195.4 progesterone0.718.80.572.390.2617.280.10.652.360.6317.779.3 17α-hydroxyprogesterone0.89.95.42.500.3141.355.91.82.440.7342.154.7 testosterone1001600232.2344.33.5649.91.31.3666.02.2630.4 in men, the concentrations of shbg, cbg, and albumin were 28 nm, 0.7 μm, and 0.56 mm, respectively. in women, the concentrations of shbg, cbg, and albumin were 37 nm, 0.7 μm, and 0.56 mm, respectively. synonyms shbg has been known under a variety of different names including: sex hormone-binding globulin (shbg) sex steroid-binding globulin (ssbg, sbg) sex steroid-binding protein (sbp, ssbp) androgen-binding protein (abp) estradiol-binding-protein (ebp) testosterone–estradiol binding globulin (tebg, tebg)