puberty blocker puberty blocker puberty blockers, also called puberty inhibitors or hormone blockers, are medicines used to postpone puberty in children. the most commonly used puberty blockers are gonadotropin-releasing hormone (gnrh) agonists, which suppress the production of sex hormones, including testosterone and estrogen. in addition to their use in treating precocious puberty (and sometimes idiopathic short stature) in children, puberty blockers are also used for transgender children to delay the development of unwanted sex characteristics, so as to allow transgender youth more time to explore their gender identity. "hormone blocker" redirects here. for testosterone blockers, see antiandrogen. for estrogen blockers, see aromatase inhibitor. the use of puberty blockers in transgender youth is supported by twelve major american medical associations, including the american medical association, the american psychological association, the american academy of pediatrics, and the endocrine society four australian medical associations, and the world professional association for transgender health (wpath). in europe some medical groups and countries have taken a somewhat more precautionary stance. for example, sweden's national board of health and welfare recommends the use of puberty blockers only in "exceptional cases" and finland's cohere council recommends that puberty blockers only be administered following individualized assessments, every such case being centrally administered. the uk's national health service currently supports the use of puberty blockers for children under 16 years of age only in the context of centrally administered clinical research, and strongly discourages seeking treatment from unregulated sources. medical uses