list of investigational sex-hormonal agents list of investigational sex-hormonal agents this is a list of investigational sex-hormonal agents, or sex-hormonal agents that are currently under development for clinical use but are not yet approved. chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. androgenics androgen receptor agonists ec586 – oral prodrug of testosterone (androgen/anabolic steroid) with improved pharmacokinetics androgen receptor antagonists bavdegalutamide (avr-110) – androgen receptor antagonist for prostate cancer clascoterone (cb-03-01, breezula, winlevi) – androgen receptor antagonist for topical treatment of scalp hair loss deutenzalutamide (deuterated enzalutamide; hc-1119) – androgen receptor antagonist for prostate cancer pruxelutamide (gt-0918; proxalutamide) – androgen receptor antagonist for prostate cancer pyrilutamide (kx-826) – androgen receptor antagonist for topical treatment of androgen-dependent scalp hair loss and acne spironolactone (aldactone) – androgen receptor antagonist for systemic treatment of acne atypical androgen receptor antagonists dimethylcurcumin (asc-j9) – androgen receptor degradation enhancer for topical acne treatment epi-7386 – n-terminal domain androgen receptor antagonist for prostate cancer [https://www.prnewswire.com/news-releases/essa-pharma-announces-nomination-of-epi-7386-as-lead-clinical-candidate-in-metastatic-castration-resistant-prostate-cancer-300820449.html androgen synthesis inhibitors seviteronel (vt-464) – cyp17a1 inhibitor (androgen synthesis inhibitor) for prostate cancer and breast cancer estrogenics estrogen receptor agonists ec508 – oral prodrug of estradiol (estrogen) with improved pharmacokinetics erteberel (ly-500307, serba-1) – selective erβ agonist for schizophrenia estetrol (donesta) – estrogen for menopausal symptoms and other indications selective estrogen receptor modulators acolbifene (em-652, sch-57068) – selective estrogen receptor modulator for breast cancer afimoxifene (4-hydroxytamoxifen; 4-oht; tamogel) – selective estrogen receptor modulator for topical treatment of breast cancer and hyperplasia amcenestrant (sar-439859; serd '859) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer camizestrant (az14066724, azd-9833) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer endoxifen (4-hydroxy-n-desmethyltamoxifen) – selective estrogen receptor modulator for breast cancer giredestrant (gdc-9545; rg-6171) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer imlunestrant (ly-3484356) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer and endometrial cancer rintodestrant (g1t-48) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer estrogen receptor antagonists fulvestrant-3 boronic acid (zb716) – estrogen receptor antagonist (antiestrogen) for breast cancer estrogen synthesis inhibitors estradiol sulfamate (e2mate, j995, pgl-2, pgl-2001, zk-190628) – steroid sulfatase inhibitor (estrogen "activation" inhibitor) for endometriosis leflutrozole (bgs-649) – aromatase inhibitor (estrogen synthesis inhibitor) for male hypogonadism progestogenics progesterone receptor agonists hydroxyprogesterone caproate (lpcn-1107) – oral progesterone receptor agonist (progestogen/progestin) for prevention of preterm labor volt-02 – water-soluble conjugate of progesterone and neurosteroid for traumatic brain injury and gynecological disorders selective progesterone receptor modulators telapristone (cdb-4124, proellex, proellex-v, progenta) – selective progesterone receptor modulator for breast cancer, endometriosis, and uterine fibroids vilaprisan (bay-1002670) – selective progesterone receptor modulator for endometriosis and uterine fibroids progesterone receptor antagonists onapristone (ar-18, ivv-1001, zk-299, zk-98299) – progesterone receptor antagonist (antiprogestogen) for prostate cancer gnrh/gonadotropins kisspeptin receptor agonists mvt-602 (rvt-602, tak-448) – small-molecule kisspeptin receptor agonist for female infertility and hypogonadism neurokinin/tachykinin receptor antagonists elinzanetant (bay-3427080; gsk-1144814; nt-814) – small-molecule nk1 receptor and nk3 receptor antagonist for hot flashes and "sex hormone disorders" fezolinetant (esn-364) – small-molecule nk3 receptor antagonist for hot flashes, polycystic ovary syndrome, and uterine fibroids mixed/combinations androgen and progesterone receptor modulators 11β-methyl-19-nortestosterone dodecylcarbonate (cdb-4754) – dual androgen/anabolic steroid and progestin for use as a male birth control pill dimethandrolone undecanoate (cdb-4521) – dual androgen/anabolic steroid and progestin for use as a male birth control pill androgen and estrogen receptor modulators acolbifene/prasterone (femivia) – selective estrogen receptor modulator and dehydroepiandrosterone supplement for hot flashes androgen, estrogen, and progesterone receptor modulators ethinylestradiol/drospirenone/prasterone – estrogen, progestogen, and dehydroepiandrosterone combination for female birth control