proxymetacaine proxymetacaine proxymetacaine (inn) or proparacaine (usan) is a topical anesthetic drug of the aminoester group. proxymetacaineclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationtopical (eye drops)atc codes01ha04 (who) pharmacokinetic datametabolismplasmaidentifiers iupac name 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate cas number499-67-2 y 5875-06-9 (hcl)pubchem cid4935iuphar/bps7283drugbankdb00807 ychemspider4766 yuniib4ob0jhi1xkeggd08448 ychemblchembl1196 ycomptox dashboard (epa)dtxsid30198146 echa infocard100.007.169 chemical and physical dataformulac16h26n2o3molar mass294.395 g·mol−13d model (jsmol)interactive image smiles o=c(occn(cc)cc)c1ccc(occc)c(c1)n inchi inchi=1s/c16h26n2o3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12h,4-6,9-11,17h2,1-3h3 ykey:kclanycvbbtkto-uhfffaoysa-n y (verify) clinical pharmacology proxymetacaine is a local anesthetic which on topical application penetrates sensory nerve endings in the corneal tissue. mechanism of action proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown. indications and usage proxymetacaine hydrochloride ophthalmic solution (eye drops) is indicated for procedures such as tonometry, gonioscopy, removal of foreign bodies, or other similar procedures requiring topical anesthesia of the cornea and conjunctiva. warnings proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. prolonged use of this or any other topical ocular anesthetic may produce permanent corneal opacification with accompanying visual loss. how supplied proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. although it is no longer on patent, it is still marketed under the trade names alcaine, ak-taine, and others. proparacaine 0.5% is marketed as poencaina by poen laboratories.