hemoglobin subunit alpha hemoglobin subunit alpha hemoglobin subunit alpha, hemoglobin, alpha 1, is a hemoglobin protein that in humans is encoded by the hba1 gene. hba1available structurespdbortholog search: pdbe rcsb list of pdb id codes1a00, 1a01, 1a0u, 1a0z, 1a3n, 1a3o, 1a9w, 1abw, 1aby, 1aj9, 1b86, 1bab, 1bbb, 1bij, 1buw, 1bz0, 1bz1, 1bzz, 1c7b, 1c7c, 1c7d, 1cls, 1cmy, 1coh, 1dke, 1dxt, 1dxu, 1dxv, 1fdh, 1fn3, 1g9v, 1gbu, 1gbv, 1gli, 1gzx, 1hab, 1hac, 1hba, 1hbb, 1hbs, 1hco, 1hdb, 1hga, 1hgb, 1hgc, 1hho, 1ird, 1j3y, 1j3z, 1j40, 1j41, 1j7s, 1j7w, 1j7y, 1jy7, 1k0y, 1k1k, 1kd2, 1lfl, 1lfq, 1lft, 1lfv, 1lfy, 1lfz, 1ljw, 1m9p, 1mko, 1nej, 1nih, 1nqp, 1o1i, 1o1j, 1o1k, 1o1l, 1o1m, 1o1n, 1o1o, 1o1p, 1qi8, 1qsh, 1qsi, 1qxd, 1qxe, 1r1x, 1r1y, 1rps, 1rq3, 1rq4, 1rqa, 1rvw, 1sdk, 1sdl, 1shr, 1si4, 1thb, 1uiw, 1vwt, 1xxt, 1xy0, 1xye, 1xz2, 1xz4, 1xz5, 1xz7, 1xzu, 1xzv, 1y01, 1y09, 1y0a, 1y0c, 1y0d, 1y0t, 1y0w, 1y22, 1y2z, 1y31, 1y35, 1y45, 1y46, 1y4b, 1y4f, 1y4g, 1y4p, 1y4q, 1y4r, 1y4v, 1y5f, 1y5j, 1y5k, 1y7c, 1y7d, 1y7g, 1y7z, 1y83, 1y85, 1y8w, 1ydz, 1ye0, 1ye1, 1ye2, 1yen, 1yeo, 1yeq, 1yeu, 1yev, 1yff, 1yg5, 1ygd, 1ygf, 1yh9, 1yhe, 1yhr, 1yie, 1yih, 1yvq, 1yvt, 1yzi, 1z8u, 2d5z, 2d60, 2dn1, 2dn2, 2dn3, 2dxm, 2h35, 2hbc, 2hbd, 2hbe, 2hbf, 2hbs, 2hco, 2hhd, 2hhe, 2m6z, 2w6v, 2w72, 2yrs, 3b75, 3d17, 3d7o, 3dut, 3hxn, 3ia3, 3ic0, 3ic2, 3kmf, 3nl7, 3nmm, 3odq, 3onz, 3oo4, 3oo5, 3ovu, 3p5q, 3qjb, 3qjc, 3qjd, 3qje, 3r5i, 3s48, 3s65, 3s66, 3szk, 3wcp, 3whm, 4fc3, 4hhb, 4ij2, 4l7y, 4m4a, 4m4b, 4mqc, 4mqg, 4mqh, 4mqi, 4mqj, 4mqk, 4n7n, 4n7o, 4n7p, 4n8t, 4ni0, 4ni1, 4rol, 4rom, 4wjg, 4x0l, 4xs0, 6hbw, 5e29, 5e6e, 5ee4, 5hu6, 5jdo, 5kdq, 5e83,%%s1y01, 1z8u, 1bz1identifiersaliaseshba1, hba-t3, hbh, hemoglobin subunit alpha 1, methba, ecyt7external idsomim: 141800 mgi: 96015 homologene: 469 genecards: hba1 gene location (human)chr.chromosome 16 (human)band16p13.3start176,680 bpend177,522 bpgene location (mouse)chr.chromosome 11 (mouse)band11 a4|11 18.86 cmstart32,233,511 bpend32,234,465 bprna expression patternbgeehumanmouse (ortholog)top expressed inmonocytebloodbone marrowbone marrow cellsplacentaspleenganglionic eminencetemporal lobeamygdalaupper lobe of left lungtop expressed inbone marrowspleenlungyolk sacneural tubemesencephalonheartcerebellar cortexzone of skinadrenal glandmore reference expression databiogpsn/agene ontologymolecular function iron ion binding oxygen binding peroxidase activity oxygen carrier activity metal ion binding protein binding heme binding haptoglobin binding organic acid binding cellular component cytosol endocytic vesicle lumen blood microparticle membrane extracellular region cytosolic small ribosomal subunit hemoglobin complex extracellular exosome haptoglobin-hemoglobin complex extracellular space biological process positive regulation of cell death protein heterooligomerization oxygen transport receptor-mediated endocytosis bicarbonate transport hydrogen peroxide catabolic process response to hydrogen peroxide cellular oxidant detoxification transport sources:amigo / quickgoorthologsspecieshumanmouseentrez303915122ensemblensg00000206172ensmusg00000069919uniprotp69905q91vb8refseq (mrna)nm_000558nm_008218refseq (protein)np_000508np_000508.1np_000549.1np_001077424location (ucsc)chr 16: 0.18 – 0.18 mbchr 11: 32.23 – 32.23 mbpubmed searchwikidataview/edit humanview/edit mouse gene the human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. the alpha-2 (hba2) and alpha-1 (hba1; this gene) coding sequences are identical. these genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. protein two alpha chains plus two beta chains constitute hba, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute hba-2, which with fetal hemoglobin (hbf) makes up the remaining 3% of adult hemoglobin. clinical significance alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both hba2 and hba1; some nondeletion alpha thalassemias have also been reported. interactions hemoglobin subunit alpha has been shown to interact with hemoglobin subunit beta (hbb).