11β-chloromethylestradiol 11β-chloromethylestradiol 11β-chloromethylestradiol (11β-cme2; developmental code name org-4333) is a synthetic steroidal estrogen which was never marketed. it has very high affinity for the estrogen receptor and dissociates from it relatively slowly. it was originally thought that 11β-cme2 might be a covalent ligand of the estrogen receptors, but its binding was subsequently shown to be fully reversible. the relative binding affinity of 11β-cme2 for the estrogen receptors ranges from 230 to 3,320% of that of estradiol depending on the study. 11β-cme2 also has about 14% of the relative binding affinity of estradiol for sex hormone-binding globulin (shbg). the compound has been developed as a radiolabel for the ers. 11β-chloromethylestradiolclinical dataother names11β-cme2; cme; org-4333; 11β-(chloromethyl)estra-1,3,5(10)-trien-3,17β-dioldrug classestrogenidentifiers iupac name (8s,9r,11s,13s,14s,17s)-11-(chloromethyl)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopentaphenanthrene-3,17-diol cas number71794-60-0 ypubchem cid67088chemspider60438uniibrp4dw4seekeggc14307chebichebi:34142comptox dashboard (epa)dtxsid40992450 chemical and physical dataformulac19h25clo2molar mass320.86 g·mol−13d model (jsmol)interactive image smiles c12c(3(1cc2o)ccc4=c3c=cc(=c4)o)ccl inchi inchi=1s/c19h25clo2/c1-19-9-12(10-20)18-14-5-3-13(21)8-11(14)2-4-15(18)16(19)6-7-17(19)22/h3,5,8,12,15-18,21-22h,2,4,6-7,9-10h2,1h3/t12-,15+,16+,17+,18-,19+/m1/s1key:cadgctowbapsfq-oqfxvxkwsa-n