non-langerhans cell histiocytosis non-langerhans cell histiocytosis non-langerhans cell histiocytosis refers to a family of histiocytosis characterized by the absence of langerhans cells. non-langerhans cell histiocytosisother nameshistiocytosis, non-langerhans-cell specialtyhematology many manifest cutaneously. the spectrum of non-langerhans cell histiocytoses include: benign cephalic histiocytosis generalized eruptive histiocytoma indeterminate cell histiocytosis juvenile xanthogranuloma progressive nodular histiocytoma necrobiotic xanthogranuloma (giant cell) reticulohistiocytoma multicentric reticulohistiocytosis rosai–dorfman disease xanthoma disseminatum kikuchi disease erdheim–chester disease.