mesocortical pathway mesocortical pathway the mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the prefrontal cortex. it is one of the four major dopamine pathways in the brain. it is essential to the normal cognitive function of the dorsolateral prefrontal cortex (part of the frontal lobe), and is thought to be involved in cognitive control, motivation, and emotional response. the mesocortical pathway is shown here in blue, projecting to the prefrontal cortex from the vta. this pathway may be the brain system that is abnormal or functioning abnormally in psychoses, such as schizophrenia. it is thought to be associated with the negative symptoms of schizophrenia, which include avolition, alogia and flat affect. this pathway is closely associated with the mesolimbic pathway, which is also known as the mesolimbic reward pathway. other dopamine pathways other major dopamine pathways include: mesolimbic pathway nigrostriatal pathway tuberoinfundibular pathway