diclofenac etalhyaluronate diclofenac etalhyaluronate diclofenac etalhyaluronate (inn, usan; trade name joycle) is an anti-inflammatory and joint function improving drug. in japan it is approved for use in the treatment of knee osteoarthritis. diclofenac etalhyaluronateclinical datatrade namesjoycleother namesdiclofenac etalhyaluronate sodium (jan); si-613legal statuslegal status rx-only in japan identifierspubchem sid348350492uniim88b0m598lkeggd11020 chemically, diclofenac etalhyaluronate consists of the drug diclofenac, a nonsteroidal antiinflammatory drug, covalently linked to hyaluronic acid. in the body, diclofenac is slowly cleaved and released, allowing diclofenac etalhyaluronate to function as a sustained-release form of diclofenac.