tofogliflozin tofogliflozin tofogliflozin (inn,: 88 usan, codenamed csg452) is an experimental drug for the treatment of diabetes mellitus and is being developed by chugai pharma in collaboration with kowa and sanofi. it is an inhibitor of subtype 2 sodium-glucose transport protein (sglt2), which is responsible for at least 90% of the glucose reabsorption in the kidney. as of september 2012, the drug is in phase iii clinical trials. tofogliflozin monohydrateclinical dataother namescsg452atc codenonelegal statuslegal status investigational identifiers iupac name (1s,3'r,4's,5's,6'r)-6-(4-ethylbenzyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3h-spiro-3',4',5'-triol hydrate (1:1) cas number1201913-82-7 903565-83-3 (anhydrous)pubchem cid46908928chemspider28527871uniip8dd8kx4o4keggd09978chemblchembl2105711comptox dashboard (epa)dtxsid70152722 chemical and physical dataformulac22h28o7molar mass404.459 g·mol−13d model (jsmol)interactive image smiles ccc1ccc(cc1)cc2ccc3c(c2)4(((((o4)co)o)o)o)oc3.o inchi inchi=1s/c22h26o6.h2o/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22;/h3-8,10,18-21,23-26h,2,9,11-12h2,1h3;1h2/t18-,19-,20+,21-,22+;/m1./s1key:zxocgddvnpdriw-nhfzgcsjsa-n chemistry anhydrous tofogliflozin the active moiety or anhydrous form (chemspider id: 28530778, chembl2110731) has the chemical formula c22h26o6 and a molecular mass of 386.44 g/mol. the united states adopted name tofogliflozin applies to the monohydrate, which is the form used as a drug. the international nonproprietary name tofogliflozin applies to the anhydrous compound and the drug form is referred to as tofogliflozin hydrate.