of as children in medical clinics was compared to an 8-year period of about 45,000 births. the swedish study showed an as prevalence of about 1/20,000 and the danish study showed a minimum as prevalence of about 1/10,000. history "boy with a puppet" or "a child with a drawing", circa 1520, by giovanni francesco caroto; the portrait motivated the initial naming of angelman syndrome as puppet syndrome. harry angelman, a pediatrician working in warrington, england, first reported three children with this condition in 1965. angelman later described his choice of the title "puppet children" to describe these cases as being related to an oil painting he had seen while vacationing in italy: the history of medicine is full of interesting stories about the discovery of illnesses. the saga of angelman's syndrome is one such story. it was purely by chance that nearly thirty years ago (e.g. , circa 1964) three handicapped children were admitted at various times to my children's ward in england. they had a variety of disabilities and although at first sight they seemed to be suffering from different conditions i felt that there was a common cause for their illness. the diagnosis was purely a clinical one because in spite of technical investigations which today are more refined i was unable to establish scientific proof that the three children all had the same handicap. in view of this i hesitated to write about them in the medical journals. however, when on holiday in italy i happened to see an oil painting in the castelvecchio museum in verona called ... a boy with a puppet. the boy's laughing face and the fact that my patients exhibited jerky movements gave me the idea of writing an article about the three children with a title of puppet children. it was not a name that pleased all parents but it served as a means of combining the three little patients into a single group. later the name was changed to angelman syndrome. this article was published in 1965 and after some initial interest lay almost forgotten until the early eighties.— angelman quoted by charles williams case reports from the united states first began appearing in the medical literature in the early 1980s. in 1987, it was first noted that around half of the children with as have a small piece of chromosome 15 missing (chromosome 15q partial deletion). society and culture many poems in richard price's poetry collections hand held (1997), lucky day (2005), and small world (2012) reflect on the disability of the poet's daughter, who has angelman syndrome. in the 2011 philippine drama series budoy, the titular character and main protagonist budoy maniego (played by filipino actor gerald anderson) is diagnosed with angelman syndrome.