decoglurant decoglurant decoglurant (inn) (code name rg1578, ro4995819) is a negative allosteric modulator of the mglu2 and mglu3 receptors which was under development by roche for the adjunctive treatment of major depressive disorder. decoglurant progressed as far as phase ii clinical trials but was ultimately discontinued from further development due to disappointing efficacy results. decoglurantclinical dataatc codenonelegal statuslegal status development terminated identifiers iupac name 5-(ethynyl)-2-pyridinamine cas number911115-16-7pubchem cid71533696chemspider32695160unii5vx4p0jkc5keggd10875chemical and physical dataformulac21h11f6n5molar mass447.344 g·mol−13d model (jsmol)interactive image smiles c1=cc(=cc=c1c2=nc3=c(c=nn3c(=c2)c(f)(f)f)c#cc4=cn=c(c=c4)n)c(f)(f)f inchi inchi=1s/c21h11f6n5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11h,(h2,28,29)key:dmjhzvarrxjseg-uhfffaoysa-n