descending limb of loop of henle descending limb of loop of henle within the nephron of the kidney, the descending limb of loop of henle is the portion of the renal tubule constituting the first part of the loop of henle. descending limb of loop of henlescheme of renal tubule and its vascular supply. (labeled at center left.)nephron ion flow diagramdetailsidentifierslatinpars descendens ansae nephricaefma17719 17705, 17719anatomical terminology physiology the permeability is as follows: substancepermeability ionslow permeability. sodium and chloride ions do not easily pass through. ureamoderate permeability. waterhighly permeable. water is readily reabsorbed from the descending limb by osmosis. also, the medullary interstitium is highly concentrated (because of the activity of the ascending limb), leading to a strong osmotic gradient from the descending limb to the medulla. because of these factors, the concentration of the urine increases dramatically in the descending limb. osmolality can reach up to 1400 mosmol/kg by the end of the descending limb. histology the epithelium of the thick segment is low simple cuboidal epithelium. the epithelium of the thin segment is simple squamous. they can be distinguished from the vasa recta by the absence of blood, and they can be distinguished from the thick ascending limb by the thickness of the epithelium. nomenclature like the ascending limb, the descending limb has thick and thin portions. however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure. the thick descending limb is less important than the thin descending limb, so often the terms "descending limb" and "thin descending limb" are used interchangeably. some sources simply refer to a "thin limb". in this context, the thin ascending limb of loop of henle would be included. additional images longitudinal section of descending limb of henle’s loop. a. membrana propria. b. epithelium.