matrine matrine matrine is an alkaloid found in plants from the genus sophora. it has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism. matrineclinical dataatc codenonelegal statuslegal status in general: unscheduled identifiers iupac name (1r,2r,9s,17s)-7,13-diazatetracycloheptadecan-6-one cas number519-02-8 ypubchem cid91466chemspider82591 nuniin390w430ackeggc10774 nchebichebi:6700 nchemblchembl204860 ncomptox dashboard (epa)dtxsid00274188 echa infocard100.117.486 chemical and physical dataformulac15h24n2omolar mass248.370 g·mol−13d model (jsmol)interactive image smiles c1c23cccn43(ccc4)cn2c(=o)c1 inchi inchi=1s/c15h24n2o/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15h,1-10h2/t11-,12+,13+,15-/m0/s1 nkey:zsbxgiujooqzmp-jlnylfassa-n n ny (what is this?) (verify) matrine possesses strong antitumor activities in vitro and in vivo. inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. matrine is a component of the traditional chinese medical herb sophora flavescens ait. mu opioid agonism is associated with euphoria, while kappa opioid agonism is associated with dysphoria and psychotomimetic hallucinations (as seen in the kappa-agonist salvinorin a). both receptors are known to produce analgesia when activated. matrine and the related compound oxymatrine have an antifeedant effect against formosan subterranean termite. additionally, it acts as a nematicide against the pine wood nematode which causes pine wilt, as well as pathogenic nematodes which target humans. matrine alleviates neuro-inflammation and oxidative stress in the brain caused by acute liver injury, thus producing antianxiety and antidepression effects.