levosulpiride levosulpiride levosulpiride, sold under the brand name neoprad, is a typical antipsychotic and a prokinetic agent of the benzamide class. it is a selective antagonist of the dopamine d2 receptors on both central and peripheral nervous systems. levosulpiride is claimed to have mood elevating properties. levosulpirideclinical dataatc coden05al07 (who) identifiers iupac name n-methyl]-2-methoxy-5-sulfamoylbenzamide cas number23672-07-3pubchem cid688272iuphar/bps958drugbankdb00391chemspider599749uniijtg7r315lkkeggd07312chebichebi:64119chemblchembl267044comptox dashboard (epa)dtxsid0042583chemical and physical dataformulac15h23n3o4smolar mass341.43 g·mol−13d model (jsmol)interactive image smiles ccn1ccc1cnc(=o)c2=c(c=cc(=c2)s(=o)(=o)n)oc inchi inchi=1s/c15h23n3o4s/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11h,3-5,8,10h2,1-2h3,(h,17,19)(h2,16,20,21)/t11-/m0/s1key:bgrjtubhpoowdu-nshdsacasa-n ny (what is this?) (verify) chemically, it is the (s)-(−)-enantiomer of sulpiride. uses levosulpiride is used in the treatment of: psychosis negative symptoms of schizophrenia anxiety disorders dysthymia vertigo dyspepsia irritable bowel syndrome premature ejaculation. levosulpiride is not currently licensed for treatment of premature ejaculation in the uk or other european countries. side effects side effects include amenorrhea, gynecomastia, galactorrhea, changes in libido, and neuroleptic malignant syndrome. in the u.s., as of 2013 only one case of adverse reaction to levosulpiride had been recorded on the fda adverse event reporting system database. a case of rapid onset resistant dystonia caused by low dose levosulpiride was reported in india. mechanism of action in contrast to most other neuroleptics which block both d1 and d2 receptors, levosulpiride is more selective and acts primarily as a d2 antagonist. levosulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, and gamma-aminobutyric acid (gaba) receptors. pharmacodynamics levosulpiride is a substituted benzamide derivative and a selective dopamine d2 antagonist with antipsychotic and antidepressant activity. other benzamide derivatives include metoclopramide, tiapride, and sultopride.