infantile systemic hyalinosis infantile systemic hyalinosis infantile systemic hyalinosis is an allelic autosomal-recessive condition characterized by multiple skin nodules, hyaline deposition, gingival hypertrophy, osteolytic bone lesions and joint contractures.: 606 infantile systemic hyalinosisother namesjuvenile systemic hyalinosisinfantile systemic hyalinosis is inherited in an autosomal recessive manner.specialtydermatology, medical genetics genetics this disease is caused by mutations in the cmg2 gene (antxr2). diagnosis