2,5-dimethoxy-4-trifluoromethylamphetamine 2,5-dimethoxy-4-trifluoromethylamphetamine 2,5-dimethoxy-4-trifluoromethylamphetamine (dotfm) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. it was first synthesized in 1994 by a team at purdue university led by david e. nichols. dotfm is the alpha-methylated analogue of 2c-tfm, and is around twice as potent in animal studies. it acts as an agonist at the 5ht2a and 5ht2c receptors. in drug-substitution experiments in rats, dotfm fully substituted for lsd and was slightly more potent than doi. 2,5-dimethoxy-4-trifluoromethylamphetamineclinical dataother names2,5-dimethoxy-4-trifluoromethylamphetaminelegal statuslegal status ca: schedule i uk: class a identifiers iupac name (rs)-1-propan-2-amine cas number159277-07-3 n 159277-12-0 (hydrochloride)pubchem cid10400521chemspider8575959 ychemblchembl6620 ycomptox dashboard (epa)dtxsid40439330 chemical and physical dataformulac12h16f3no2molar mass263.260 g·mol−13d model (jsmol)interactive image smiles fc(f)(f)c1cc(oc)c(cc1oc)cc(n)c inchi inchi=1s/c12h16f3no2/c1-7(16)4-8-5-11(18-3)9(12(13,14)15)6-10(8)17-2/h5-7h,4,16h2,1-3h3 ykey:wpgotsordnbmhp-uhfffaoysa-n y ny (what is this?) (verify)