amiflamine amiflamine amiflamine (fla-336) is a reversible inhibitor of monoamine oxidase a (mao-a), thereby being a rima, and, to a lesser extent, semicarbazide-sensitive amine oxidase (ssao), as well as a serotonin releasing agent (sra). it is a derivative of the phenethylamine and amphetamine chemical classes. the (+)-enantiomer is the active stereoisomer. amiflamineclinical dataother names(+)-4-(dimethylamino)-α,2-dimethylphenethylamineroutes ofadministrationoralatc codenonelegal statuslegal status in general: uncontrolled identifiers iupac name 4--n,n,3-trimethylaniline cas number77518-07-1 ypubchem cid71221chemspider64356 yuniine25wv9c8schemblchembl30344 ncomptox dashboard (epa)dtxsid00228222 chemical and physical dataformulac12h20n2molar mass192.306 g·mol−13d model (jsmol)interactive image smiles n(c1cc(c(cc1)c(n)c)c)(c)c inchi inchi=1s/c12h20n2/c1-9-7-12(14(3)4)6-5-11(9)8-10(2)13/h5-7,10h,8,13h2,1-4h3/t10-/m0/s1 ykey:hfqmyshattxrtc-jtqlqieisa-n y ny (what is this?) (verify) amiflamine shows preference for inhibiting mao-a in serotonergic relative to noradrenergic and dopaminergic neurons. in other words, at low doses, it can be used to selectively inhibit mao-a enzymes in serotonin cells, whereas at higher doses it loses its selectivity. this property is attributed to amiflamine's higher affinity for the serotonin transporter over the norepinephrine and dopamine transporters, as transporter-mediated carriage is required for amiflamine to enter monoaminergic neurons.