benign symmetric lipomatosis benign symmetric lipomatosis benign symmetric lipomatosis is a skin condition characterized by extensive symmetric fat deposits in the head, neck, and shoulder girdle area. the german surgeon otto wilhelm madelung was the first to give a detailed description of the disorder. this condition is very rare, with an estimated incidence of 1 in 25,000, and affects males up to 30 times more frequently than females. benign symmetric lipomatosisother namesbenign symmetric lipomatosis of launois–bensaude, madelung's disease, multiple symmetric lipomatosis, cephalothoracic lipodystrophya young man with benign symmetric lipomatosis (madelung's disease) of unknown causespecialtyendocrinology cause the cause of the disease remains unknown, but its incidence strongly correlates with alcohol use disorder; abstinence from alcohol prevents disease progression. defects in the adrenergic-stimulated lipolysis and accumulation of embryological brown fat have also been reported. cosmetic disfigurement due to the fat deposition in the cervicothoracic region results in a "pseudoathletic appearance", resembling the italian statue warrior of capestrano and carvings of queen of punt (egypt). treatment traditionally the treatment is mainly surgical, consisting of the removal of the lipomas, although recent study has proposed liposuction and phosphatidylcholine injection as possible alternatives. society the appearance of people with the disease is depicted in: carvings of queen of punt (egypt), as noted above the italian statue the warrior of capestrano, as noted above donna leon's crime novel, beastly things (2012), wherein the protagonist investigates the murder of a man who had the condition, which brunetti learns has a high incidence in italy