current applications of contrast enhanced ultrasound. currently investigated clinical uses the only use of acoustic angiography that has been investigated in clinical settings to date studied angiogenesis in the peripheral vasculature of human breast tissue. this study investigated if acoustic angiography could be used to reduce the need for biopsy of breast tissue when diagnosing if lesions in breast tissue were cancerous or not. using acoustic angiography, the authors collected and reconstructed the 3d volumes associated with vasculature surrounding lesions in the breast. these reconstructed volumes were then analyzed for vascular density and tortuosity. this information is useful for diagnosis as it has been shown that when these two factors increase in the vasculature surrounding a lesion, there is an increased risk that the lesion is cancerous.