neosalvarsan neosalvarsan neosalvarsan is a synthetic chemotherapeutic that is an organoarsenic compound. it became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis. because both of these arsenicals carried considerable risk of side effects, they were replaced for this indication by penicillin in the 1940s. neosalvarsan names other names sodium 3,3'-diamino-4,4'-dihydroxyarsenobenzene-n-formaldehydesulfoxylate; neoarsphenamine;914 identifiers cas number 457-60-3 y 3d model (jsmol) interactive image chemspider 9586 y echa infocard 100.006.613 pubchem cid 9980 unii o7k7r0o4bg y comptox dashboard (epa) dtxsid60196599 inchi inchi=1s/c13h14as2n2o4s.na/c16-10-5-8(1-3-12(10)18)14-15-9-2-4-13(19)11(6-9)17-7-22(20)21;/h1-6,17-19h,7,16h2,(h,20,21);/q;+1/p-1 ykey: bgysjufvjujsol-uhfffaoysa-m yinchi=1/c13h14as2n2o4s.na/c16-10-5-8(1-3-12(10)18)14-15-9-2-4-13(19)11(6-9)17-7-22(20)21;/h1-6,17-19h,7,16h2,(h,20,21);/q;+1/p-1key: bgysjufvjujsol-rewhxwofao smiles .s(=o)cnc2cc(/=/c1ccc(o)c(n)c1)ccc2o properties chemical formula c13h13as2n2nao4s molar mass 466.15 g/mol except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). y verify (what is yn ?) infobox references both salvarsan and neosalvarsan were developed in the laboratory of paul ehrlich in frankfurt, germany. their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications. this scheme is the basis for most modern pharmaceutical research. both salvarsan and neosalvarsan are prodrugs – that is, they are metabolised into the active drug in the body. although, like salvarsan, it was originally believed to contain an arsenic-arsenic double bond, this is now known to be incorrect, and exists as a mixture of differently sized rings with arsenic-arsenic single bonds.