androgen deprivation-induced senescence androgen deprivation-induced senescence androgen deprivation-induced senescence (or adis) refers to the induction of cellular senescence as a result of androgen deprivation therapy. adis is observed in prostate cancer cells that are dependent on androgens for cell proliferation. androgen withdrawal induces cells to undergo cellular senescence by up-regulating intracellular reactive oxygen species (ros) that cause dna damage. adis is maintained through the up-regulation of the cell cycle regulator p16ink4a.