hu-308 hu-308 hu-308 (also known as onternabez, hu308, ppp-003 and ards-003) is a cannabidiol (cbd)-derivative drug that acts as a potent cannabinoid agonist. it is highly selective for the cannabinoid-2 receptor (cb2 receptor) subtype, with a selectivity more than 5,000 times greater for the cb2 receptor than the cb1 receptor. the synthesis and characterization of hu-308 took place in the laboratory of raphael mechoulam at the hebrew university of jerusalem (the hu in hu-308) in the late 1990s. the pinene dimethoxy-dmh-cbd derivative hu-308 was identified as a potent peripheral cb2-selective agonist in in vitro and animal studies in 1990 and 1999. hu-308legal statuslegal status ca: schedule ii uk: class b us: unscheduled florida: schedule i pharmacokinetic datametabolismliverexcretionkidneysidentifiers iupac name -7,7-dimethyl-4-bicyclohept-3-enyl]methanol cas number256934-39-1 ypubchem cid11553430chemspider8020425unii8i5l034d55keggd12305chebichebi:146244comptox dashboard (epa)dtxsid901010005 chemical and physical dataformulac27h42o3molar mass414.630 g·mol−13d model (jsmol)interactive image smiles ccccccc(c)(c)c1=cc(=c(c(=c1)oc)2c=c(3c2c3(c)c)co)oc inchi inchi=1s/c27h42o3/c1-8-9-10-11-12-26(2,3)19-14-23(29-6)25(24(15-19)30-7)20-13-18(17-28)21-16-22(20)27(21,4)5/h13-15,20-22,28h,8-12,16-17h2,1-7h3/t20-,21-,22+/m0/s1key:cfmrivodixterw-fdfhnconsa-n ny (what is this?) (verify) legal status tetra bio-pharma owns the intellectual property rights to hu-308. hu-308 is non-psychoactive and not scheduled at the federal level in the united states. it is a schedule i controlled substance in the state of florida making it illegal to buy, sell, or possess there.