lymphocytic colitis lymphocytic colitis lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody watery diarrhea. lymphocytic colitismicrograph of lymphocytic colitis. hps stain.specialtygastroenterology presentation causes no definite cause has been determined. the peak incidence of lymphocytic colitis is in persons over age 50; the disease affects women and men equally. some reports have implicated long-term usage of nsaids, proton pump inhibitors, and selective serotonin reuptake inhibitors, and other drugs. associations with other autoimmune disorders suggests that overactive immune responses occur. diagnosis the colonoscopy is normal but histology of the mucosal biopsy reveals an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria). collagenous colitis shares this feature but additionally shows a distinctive thickening of the subepithelial collagen table. treatment budesonide, in colonic release preparations, has been shown in randomized controlled trials to be effective in treating this disorder. it helps control the diarrheal symptoms and treatment is usually given for several weeks. sometimes it is used to prevent frequent relapses. over-the-counter antidiarrheal drugs may be effective for some people with lymphocytic colitis. anti-inflammatory drugs, such as salicylates, mesalazine, and systemic corticosteroids may be prescribed for people who do not respond to other drug treatment. the long-term prognosis for this disease is good with a proportion of people suffering relapses which respond to treatment. history lymphocytic colitis was first described in 1989.