ketodarolutamide ketodarolutamide ketodarolutamide (developmental code names orm-15341, bay-1896953) is a nonsteroidal antiandrogen (nsaa) and the major active metabolite of darolutamide (odm-201, bay-1841788), an nsaa which is used in the treatment of prostate cancer in men. similarly to its parent compound, ketodarolutamide acts as a highly selective, high-affinity, competitive silent antagonist of the androgen receptor (ar). both agents show much higher affinity and more potent inhibition of the ar relative to the other nsaas enzalutamide and apalutamide, although they also possess much shorter and comparatively less favorable elimination half-lives. they have also been found not to activate certain mutant ar variants that enzalutamide and apalutamide do activate. both darolutamide and ketodarolutamide show limited central nervous system distribution, indicating peripheral selectivity, and little or no inhibition or induction of cytochrome p450 enzymes such as cyp3a4, unlike enzalutamide and apalutamide. ketodarolutamideclinical dataother namesorm-15341; bay-1896953drug classnonsteroidal antiandrogenpharmacokinetic dataelimination half-life10.0 hoursidentifiers iupac name 3-acetyl-n-propan-2-yl]-1h-pyrazole-5-carboxamide cas number1297537-33-7pubchem cid52919826chemspider38772344unii9eps75qmtlecha infocard100.235.511 chemical and physical dataformulac19h17cln6o2molar mass396.84 g·mol−13d model (jsmol)interactive image smiles c(cn1c=cc(=n1)c2=cc(=c(c=c2)c#n)cl)nc(=o)c3=cc(=nn3)c(=o)c inchi inchi=1s/c19h17cln6o2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11h,10h2,1-2h3,(h,22,28)(h,23,24)/t11-/m0/s1key:gmbpvbvtpbwikc-nshdsacasa-n