oxprenolol oxprenolol oxprenolol (brand names trasacor, trasicor, coretal, laracor, slow-pren, captol, corbeton, slow-trasicor, tevacor, trasitensin, trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. it is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure. oxprenololclinical dataahfs/drugs.commicromedex detailed consumer informationpregnancycategory au: c routes ofadministrationby mouthatc codec07aa02 (who) legal statuslegal status in general: ℞ (prescription only) pharmacokinetic databioavailability20-70%metabolismliverelimination half-life1-2hoursexcretionkidney lactic (in lactiferous females)identifiers iupac name (rs)-1--3-(isopropylamino)propan-2-ol cas number6452-71-7 ypubchem cid4631iuphar/bps7255drugbankdb01580 nchemspider4470 yunii519mxn9yzrkeggd08318 ychemblchembl546 ycomptox dashboard (epa)dtxsid1043835 echa infocard100.026.598 chemical and physical dataformulac15h23no3molar mass265.348 g·mol−13d model (jsmol)interactive imagechiralityracemic mixture smiles o(c1ccccc1oc\c=c)cc(o)cnc(c)c inchi inchi=1s/c15h23no3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17h,1,9-11h2,2-3h3 ykey:cemawmomdpgjmb-uhfffaoysa-n y ny (what is this?) (verify) oxprenolol is a lipophilic beta blocker which passes the blood–brain barrier more easily than water-soluble beta blockers. as such, it is associated with a higher incidence of cns-related side effects than beta blockers with more hydrophilic molecules such as atenolol, sotalol and nadolol. oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation. pharmacology pharmacodynamics oxprenolol is a beta blocker. in addition, it has been found to act as an antagonist of the serotonin 5-ht1a and 5-ht1b receptors with respective ki values of 94.2 nm and 642 nm in rat brain tissue. chemistry stereochemistry oxprenolol is a chiral compound, the beta blocker is used as a racemate, e. g. a 1:1 mixture of (r)-(+)-oxprenolol and (s)-(–)-oxprenolol. analytical methods (hplc) for the separation and quantification of (r)-(+)-oxprenolol and (s)-(–)-oxprenolol in urine and in pharmaceutical formulations have been described in the literature. (r)-(+)-oxprenolol (top) and (s)-(–)-oxprenolol