tigatuzumab tigatuzumab tigatuzumab (cs-1008) is a monoclonal antibody for the treatment of cancer. as of october 2009, a clinical trial for the treatment of pancreatic cancer, phase ii trials for colorectal cancer, non-small cell lung cancer, and ovarian cancer have been completed. tigatuzumabmonoclonal antibodytypewhole antibodysourcehumanized (from mouse)targettnfrsf10b (trail-r2)clinical dataatc codenoneidentifierscas number918127-53-4 nchemspidernoneunii237gb6idkochemical and physical dataformulac6406h9924n1716o2012s46molar mass144646.62 g·mol−1 ny (what is this?) (verify) the drug targets member 10b of the tumor necrosis factor receptor superfamily (tnfrsf10b, better known as death receptor 5 or trail receptor 2), a protein with limited expression in normal tissues but overexpressed in many kinds of tumours, including colon, gastric, pancreatic, lung, and cervical. in 2015, a phase i study was completed to investigate how biodistribution, quantitative tumor uptake, and antitumor response in patients with metastatic colorectal cancer was impacted by cs-1008. these objectives were tracked through use of trace-labeling and spect imaging over the course of treatment and found heterogeneity of tigatuzumab uptake in tumors, that tigatuzumab uptake is not dose dependent, and that tigatuzumab uptake is predictive of clinical response in the treatment of metastatic colorectal cancer.