sedoanalgesia sedoanalgesia sedoanalgesia is the practice of combining sedation with local anesthesia, usually in the case of surgery. in medical studies, administering sedoanalgesia has been shown to be cost- and time-effective when compared to general or regional anesthesia, and it can reduce the amount of nursing staff, anesthetists, and equipment required for a given procedure. frequently used in patients who present with considerable risk from conventional anesthesia and with elderly patients with co-morbid medical conditions. medical uses used in endoscopic gastrointestinal procedures, dental procedures, and minimally invasive surgeries.