uzbekistan cough syrup scandal uzbekistan cough syrup scandal the uzbekistan cough syrup scandal was a series of poisonings that resulted in the deaths of 18 children in samarkand and two more children elsewhere in uzbekistan. it was caused by the drug dok-1 max produced by the company marion biotech pvt. ltd. which operates in india. as a result of laboratory studies, the toxic substance ethylene glycol was found in the composition of the drug. the indian government opened a case against marion biotech, while the uzbek authorities opened a criminal case against several members of the health system and the employees of the hospital where the children died. uzbekistan cough syrup scandala warning not to take dok-1 max tablets as issued by the uzbekistan ministry of healthdatedecember 24, 2022 — january 13, 2023 (2 weeks and 6 days)locationprimarily samarkand regionthememedicinedeaths20 on december 22, the sale and distribution of dok-1 max was temporarily suspended, and officially banned in the country on december 29. a doctor who discovered that the syrup contained a poisonous substance was released from his duties. the production process of drugs with this and similar composition at the company's factories was stopped under the influence of the indian government. in connection with this situation, uzbekistani president shavkat mirziyoyev released sardor kariyev, the director of the agency for the development of the pharmaceutical network under the ministry of health. it is claimed that contacts between the world health organization and uzbekistan officials have been established regarding the situation, and the investigation is still ongoing. the customs committee prevented the distribution of about 60,000 boxes of medicines on the day when news of the incident began to spread. in the wake of the event, the indian government suspended the license of marion biotech on january 10, 2023. background dok-1 max is a combination drug produced in syrup and tablet form that is intended to combat the symptoms of acute respiratory diseases. as such, it is mainly used in cases of whooping cough, runny nose, wet cough, sore throat, angina, headache, body aches and fever. the instructions of pharmacists indicate that the drug can be used in children aged 2 and over. however, similar formulations in drugs from other companies are mainly recommended for those over 12 years of age. each 10 ml dose of the drug contains: paracetamol (500 mg), guaifenesin (200 mg), phenylephrine hydrochloride (10 mg), as well as sorbitol propylene glycol, sodium benzoate, citric acid monohydrate, sodium saccharin, sucralose, glycerol, caramel color, ice lemon flavor, menthol and purified water. the color is light brown, and the liquid has a smell and a sweet lemon taste. the drug was made available in uzbekistan from 2012 to 2022 and imported under the limited liability company kuramax medikal. in the period from september 5 to december 13, 2022, 11 series of dosing devices were certified. toxicity further information: ethylene glycol poisoning laboratory studies of dok-1 max syrup following the poisonings found ethylene glycol to be the cause of the product's toxicity. quality control investigations conducted by the ministry of health showed that some releases of dok-1 max and ambronol drugs contained ethylene glycol and diethylene glycol instead of propylene glycol (or combined with it). ethylene glycol is a toxic substance, and a 95% concentrated solution of about 1-2 ml/kg can cause serious health effects, including vomiting, seizures, syncope, acute renal failure, and cardiovascular dysfunction. concentrations of ethylene glycol and/or diethylene glycol in the cough syrup were found to be 300 times higher than the established standard. incidents an official letter from the head of the children's multidisciplinary medical center of the samarkand region, mamatkul azizov, to the head of the health department of the regional government, davronbek jumaniozov, on december 15, describes the tragic circumstances related to dok-1 max to have happened "in the last 2 months". oltinoy esanova, the deputy head of the syrdarya region health department, reported that the drug had a negative effect on seven children. 3 of the patients are in the intensive care unit, and 4 have recovered. the information advised parents to refer children under 6 years of age who have received dok-1 max to family hospitals, even if there are no side effects. abduqayum tokhtaqulov, the head of the health department of fergana region, reported to the national news agency that a 3-year-old boy was poisoned. in his message, he noted that the condition of the patient from the city of kuvasoy was serious and that he was currently being treated on the basis of specially approved standards. tokhtakulov also told parents that they should keep their children away from such drugs and not to give them to their children. there were also reports that 9 children were poisoned in tashkent region. according to the report of the regional administration, until now there had been no cases of death in the region due to the drug. it was reported in the media that 5 of the children in the region recovered, and the condition of 4 was stable. akmal askarov, deputy minister of karakalpakstan, told the reporter of karakalpakstan tv channel that 2 children were poisoned by the dok-1 max and were sent to the capital for treatment. spokesman of the ministry s. ziyayev noted that the condition of the children was average, with renal toxicity being observed. deaths cases of death in young children were recorded in samarkand (18), kashkadarya (1) and namangan (1) regions. 18 children died in the children's multidisciplinary medical center located in samarkand after taking cough syrup produced in india. human rights representative of the oliy majlis, ombudsman aliya yunusova, representatives of the child rights protection sector and prosecutor's office conducted a special study on children who died in this hospital, showing that all of the dead children were under the age of 6, and 15 of them were children under the age of 3. the patients who died in samarkand were from jizzakh, kashkadarya, navoi and samarkand regions. on december 29, 2022, the number of children who died as a result of taking this drug reached 20. a child born on august 14, 2021, in dehqonabad district of kashkadarya region was brought to the kashkadarya branch of the emergency medical center of the republic of uzbekistan on december 27 under the effects of the syrup. the child died on december 28, despite the medical assistance provided. one of the family members of the deceased child told daryo.uz about the development of events: people at the emergency center did not accept my nephew and said that he should be taken to the capital. while the child was being taken to tashkent, emergency medical workers asked to bring him back. we found out that my nephew was poisoned by that drug through the results of medical examinations in karshi. we thought it was flu symptoms. when the doctors said, "what kind of medicine have you given him, send the picture", we send the picture. doctors said that the drug had severely damaged the child's organs such as kidneys and liver. we heard about the ban on this medicine after my nephew finished taking it. by then it was too late.— shahnoza nafasova, aunt of the deceased child out of 43 children with acute respiratory diseases, 20 who died shortly after admission were found to have taken excessive amounts of the dok-1 max syrup, sometimes consisting of 2.5 to 5 ml 3-4 times a day for 2–7 days. responses the sale and distribution of imported cough syrup was temporarily suspended on december 22. during a briefing held on december 29, 2022, with the participation of sevara ubaidullayeva, the head of the department of maternity and child protection of the ministry of health of uzbekistan, special recommendations were given to people who took dok-1 max, saying that patients who did not develop various symptoms days after taking the drug should not be alarmed. after it was disclosed that several batches of dok-1 max and other similar cold syrups were found to contain toxic substances, their sale was banned, but it was reported that some pharmacies were still engaged in selling such drugs. that month, 3 imported batches of the dok-1 max (about 60,000 boxes) were placed under strict control by officials of the state customs committee against in response to the health crisis. ministry of health in connection with the incident, officials of the ministry of health of uzbekistan reported that they formed a special working group consisting of qualified specialists of the state center for expertise and standardization of medicines, medical products and medical equipment in order to study the negative symptoms caused by the adulterated drug. the message stated that there was a criminal motivation behind the incident, that 7 persons responsible were fired, and that the identified information was sent to the law enforcement authorities. according to the report, the medicine was bought without a doctor's prescription, independently on the recommendation of pharmacists, and was taken in an overdose. behzod musayev, the minister of the health department of republic of uzbekistan, sent a video message of condolence to the parents and relatives of 18 children who died after taking the dok-1 max drug. the head of the department of motherhood and child protection stated that the result of a study conducted by the special working group appointed by the ministry showed that the condition observed in children under the influence of syrup had been obtained more than 2 months since its onset; the fact that hospital officials did not provide prompt information on the incident to the ministry on the same day further complicated the situation. marion biotech pvt. ltd we are sorry for the death, the government is investigating. based on the results, we will take appropriate action. samples have already been taken. production of this product has been discontinued, other processes are in progress.— hasan raza. world health organization (who) since december 27, who has been in contact with government officials in uzbekistan regarding the deaths of children who died after consuming dok-1 max cough syrup: we are in contact with the authorities of uzbekistan and are busy collecting information about 18 dead children— who officials. the total number of deaths from the toxic cough syrup across three countries of the world was 300, as announced by the world health organization announced in a press release: more than 300 people have died in the past 4 months from over-the-counter cough syrups with high levels of diethylene glycol (deg) and ethylene glycol (eg).— world health organization president of uzbekistan sardor kariyev, who had been working as the director of the agency for the development of the pharmaceutical network under the ministry of health of uzbekistan since february 2019, was relieved of his duties at a meeting held by the president of the republic on december 30. the president also learned about the death of children in samarkand. he criticized officials of the field who were connected to the situation: the death of children in samarkand and kashkadarya showed the state of affairs in the field and lack of control. today i fired kariyev, the head of the pharmaceutical agency. all the officials who allowed this will be held responsible to the law! — shavkat mirziyoyev. criminal investigation following the scandal, the indian government has launched an investigation against marion biotech. the company, who manufactured the dok-1 max drug, was registered as a small producer in india in 2010 and as an international exporter in 2016. kuramax medikal llc, which imported the company's products to uzbekistan, was registered in uzbekistan in 2006, headed by singh ragvendra pratar. the narcotics licensing and control authority of uttar pradesh has been entrusted with the investigation. on december 29, 2022, marion biotech officially stopped the production of its dok-1 max cough syrup, which had caused the death of more than 20 children in uzbekistan. according to the economic times, the investigative commission asked the government of uzbekistan for a report on children who died as a result of drug. in connection with this incident, the investigation department of the state security service of uzbekistan initiated a criminal case against the officials of kuramax medikal and scientific center for standardization of medicines under article 186–3, part 4, clause "a" of the criminal code. suspects were arrested. among the 7 officials released from