cfu-meg cfu-meg cfu-meg is a colony forming unit. haematopoiesis in the bone marrow starts off from a haematopoietic stem cell (hsc) and this can differentiate into the myeloid and lymphoid cell lineages. in order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, cfu-gemm. this in turn develops into cfu-meg, which is the colony forming unit that leads to the production of megakaryocytes. cfu-megdetailsgives rise tomegakaryocytes and those to plateletslocationbone marrowfunctioncolony forming unitidentifiersthh2.00.04.3.02013 anatomical terms of microanatomy some sources prefer the term "cfu-mega".