girisopam girisopam girisopam (gyki-51189, egis-5810) is a drug which is a 2,3-benzodiazepine derivative, related to tofisopam and zometapine. it has selective anxiolytic action with no sedative, anticonvulsant or muscle relaxant effects. girisopamclinical dataatc codenoneidentifiers iupac name 1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine cas number82230-53-3 ypubchem cid71257chemspider64387 yunii2lp301a921chemblchembl1915065 ncomptox dashboard (epa)dtxsid70231642 chemical and physical dataformulac18h17cln2o2molar mass328.79 g·mol−13d model (jsmol)interactive image smiles clc3cccc(c\2=n\n=c(/cc1c/2cc(oc)c(oc)c1)c)c3 inchi inchi=1s/c18h17cln2o2/c1-11-7-13-9-16(22-2)17(23-3)10-15(13)18(21-20-11)12-5-4-6-14(19)8-12/h4-6,8-10h,7h2,1-3h3 ykey:vqylgvvodfdfnk-uhfffaoysa-n y ny (what is this?) (verify) synthesis patent: starting material: intermediate method: henry reaction between veratraldehyde (1) and nitroethane gives 1,2-dimethoxy-4-(2-nitropropenyl)benzene (2). treatment with iron and muriatic acid in the presence of iron trichloride catalyst gives 3,4-dimethoxyphenylacetone (3). the reduction of the ketone with sodium borohydride gives 1-(3,4-dimethoxyphenyl)-2-propanol (4). treatment with formaldehyde in acid gives 6,7-dimethoxy-3-methyl-1h-isochromene, cid:57074411 (5). oxidation by chromium trichloride gives 3-methyl-6,7-dimethoxyisocoumarin, cid:12349213 (6). grignard reaction with 1-bromo-3-chlorobenzene (7) gives (8). treatment with perchloric acid leads to 1-(3-chlorophenyl)-3-methyl 6,7-dimethoxy-2-benzopyrylium perchlorate cid:14502385 (9). ex 39: the reaction between (9) and hydrazine hydrate (10) in methanol solvent gives girisopam (11).