sulprostone sulprostone sulprostone is an analogue of prostaglandin e2 (pge2) that has oxytocic activity in assays of rat kidney cells and tissues. there are four known receptors which mediate various but often different cellular and tissue responses to pge2: prostaglandin ep1 receptor, prostaglandin ep2 receptor, prostaglandin ep3 receptor, and prostaglandin ep4 receptor. sulprosotone binds to and activates the prostaglandin ep3 receptor with far greater efficacy than the other pge2 receptors and also has the advantage of being relatively resistant, compared with pge2, to becoming metabolically degraded. it is listed as a comparatively weak receptor agonist of the prostaglandin ep1 receptor. in all events, this as well as other potent synthetic ep3 receptor antagonists have the realized or potential ability to promote the beneficial effects of prostaglandin ep3 receptor activation. sulprostoneclinical dataahfs/drugs.cominternational drug namesatc codeg02ad05 (who) identifiers iupac name (z)-7--5-oxocyclopentyl]-n-methylsulfonylhept-5-enamide cas number60325-46-4 npubchem cid5312153chemspider4471583 nunii501q5eq1gmkeggd02725 ychemblchembl284178 ncomptox dashboard (epa)dtxsid5049029 echa infocard100.056.503 chemical and physical dataformulac23h31no7smolar mass465.56 g·mol−13d model (jsmol)interactive image smiles cs(=o)(=o)nc(=o)ccc/c=c\c1((cc1=o)o)/c=c/(coc2ccccc2)o inchi inchi=1s/c23h31no7s/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-20,22,25,27h,3,8,11-12,15-16h2,1h3,(h,24,28)/b7-2-,14-13+/t17-,19-,20-,22-/m1/s1 nkey:uqzvcdcimblvnr-twyodkafsa-n n ny (what is this?) (verify) sulprostone (as well as other prostanoids receptor agonists) is in use for inducting medical abortion and ending pregnancy after fetal death, for the treatment of severe atonic postpartum hemorrhage after vaginal delivery, and for removal of the placenta in patients with retained placenta. currently, sulprostone along with sc-46275, mb-28767, ono-ae-248 and other ep3 receptor agonists are in development as drugs for the possible treatment of stomach ulcers in humans.