skf-83,959 skf-83,959 skf-83,959 is a synthetic benzazepine derivative used in scientific research which acts as an agonist at the d1–d2 dopamine receptor heteromer. it behaves as a full agonist at the d1 protomer and a high-affinity partial agonist at the d2 protomer. it was further shown to act as an allosteric modulator of the sigma-1 receptor. skf-83,959 additionally inhibits sodium channels as well as delayed rectifier potassium channels. skf-83,959 is a racemate that consists of the r-(+)- and s-(−)-enantiomers mcl-202 and mcl-201, respectively. skf-83,959identifiers iupac name 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine pubchem cid24278699chemspider10131933 yunii8cj9f3c4q0chemblchembl520992 ychemical and physical dataformulac18h20clno2molar mass317.81 g·mol−13d model (jsmol)interactive image smiles br.clc1c3c(cc(o)c1o)c(c2cccc(c2)c)cn(cc3)c inchi inchi=1s/c18h20clno2.brh/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22h,6-7,10h2,1-2h3;1h ykey:fhywnbufnghncp-uhfffaoysa-n y (verify) skf-83,959 was described as a sndri. the synthesis has been described: