sb-258585 sb-258585 sb-258585 is a drug which is used in scientific research. it acts as a potent, selective and orally active 5-ht6 receptor antagonist, with a ki of 8.9nm. it is used in its 125i radiolabelled form to map the distribution of 5-ht6 receptors in the brain. sb-258585identifiers iupac name 4-iodo-n-benzenesulfonamide cas number209480-63-7 ypubchem cid3248571iuphar/bps3232chemspider2498938 nunii54bp69j53fchemblchembl60264 nchemical and physical dataformulac18h22in3o3smolar mass487.36 g·mol−13d model (jsmol)interactive image smiles c3cn(c)ccn3c1cc(ccc1oc)ns(=o)(=o)c2ccc(i)cc2 inchi inchi=1s/c18h22in3o3s/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16/h3-8,13,20h,9-12h2,1-2h3 nkey:bdhmsynbsbzcaf-uhfffaoysa-n n ny (what is this?) (verify) sb-258585 and other 5-ht6 antagonists show nootropic effects in animal studies, as well as antidepressant and anxiolytic effects, and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and alzheimer's disease.