quinoxalinedione quinoxalinedione quinoxalinedione is an organic compound with the formula c6h4(nh)2(co)2. it is a colorless solid that is soluble in polar organic solvents. quinoxalinediones are a family of related compounds sharing the same bicyclic core. various quinoxalinediones are drugs. quinoxalinedione names preferred iupac name 1,4-dihydroquinoxaline-2,3-dione identifiers cas number 15804-19-0 y 3d model (jsmol) interactive image echa infocard 100.036.259 ec number 239-901-0 pubchem cid 11469229 unii apo55iz9e1 y comptox dashboard (epa) dtxsid9065946 inchi inchi=1s/c8h4n2o2/c11-7-8(12)10-6-4-2-1-3-5(6)9-7/h1-4hkey: sepkunxlgwmphl-uhfffaoysa-n smiles c1=cc2=nc(=o)c(=o)n=c2c=c1 properties chemical formula c8h6n2o2 molar mass 162.15 appearance white solid density 1.549 g/cm3 melting point > 300 °c (572 °f; 573 k) hazards ghs labelling: pictograms signal word warning hazard statements h302, h315, h318, h319, h335 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references synthesis and structure quinoxalinedione is produced by condensation of dimethyloxalate and o-phenylenediamine: c2o2(ome)2 + c6h4(nh2)2 → c6h4(nh)2(co)2 + 2 meoh the compound exists in solution and the solid state predominantly as the diamide form. some reactions of the compound indicate a role for the diol tautomer. drugs based on quinoxalinediones quinoxalinediones act as antagonists of the ampa, kainate, and/or nmda receptors of the ionotropic glutamate receptor family. examples include the following: acea-1011 becampanel cnqx dnqx fanapanel (mpqx) licostinel (acea-1021) nbqx pnqx ym90k zonampanel a drug closely related to the quinoxalinediones, but possessing a quinazoline-2,4-dione structure instead, is selurampanel. caroverine is another closely related drug to the above, but instead containing a quinoxaline-2-one structure.