ly-404187 ly-404187 ly-404187 is an ampa receptor positive allosteric modulator which was developed by eli lilly and company. it is a member of the biarylpropylsulfonamide class of ampa receptor potentiators. ly-404187clinical dataother namesly-404,187; n-2-propyl-2-propanesulfonamideatc codenonelegal statuslegal status us: investigational new drug identifiers iupac name n-propane-2-sulfonamide cas number211311-95-4 ychemspider18962921 nunii75w6i8w6oucomptox dashboard (epa)dtxsid00432983 chemical and physical dataformulac19h22n2o2smolar mass342.46 g·mol−13d model (jsmol)interactive image smiles n#cc2ccc(cc2)-c1ccc(c(c)cns(=o)(=o)c(c)c)cc1 inchi inchi=1s/c19h28n2o2s/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-7,14-15,17,19,21h,8-11,13h2,1-3h3 nkey:aialbpyhygyyrb-uhfffaoysa-n n ny (what is this?) (verify) ly-404187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, parkinson's disease and adhd. these effects appear to be mediated through multiple mechanisms of action secondary to ampa receptor potentiation, with a prominent effect seen in research being increased levels of bdnf in the brain. it may therefore be continued on to human trials, although eli lilly has developed a whole family of biarylpropylsulfonamide derivatives and it is unclear at this stage which compound is most likely to be selected for further development.