complement component 7 complement component 7 complement component 7 is a protein involved in the complement system of the innate immune system. c7 is part of the membrane attack complex (mac) which creates a hole on pathogen surfaces, leading to cell lysis and death. c7available structurespdbortholog search: pdbe rcsb list of pdb id codes2wcyidentifiersaliasesc7, complement component 7, complement c7external idsomim: 217070 mgi: 88235 homologene: 489 genecards: c7 gene location (human)chr.chromosome 5 (human)band5p13.1start40,909,492 bpend40,984,643 bpgene location (mouse)chr.chromosome 15 (mouse)band15 a1|15 1.98 cmstart5,018,244 bpend5,093,222 bprna expression patternbgeehumanmouse (ortholog)top expressed insuperficial temporal arterypericardiumgastric mucosaleft adrenal glandgallbladderright coronary arteryleft uterine tubelower lobe of lungperitoneumleft coronary arterytop expressed inzone of skinspermatidesophaguslungtesticlespermatocytewhite adipose tissueskeletal muscle tissueadrenal glandquadriceps femoris musclemore reference expression databiogpsn/agene ontologymolecular function growth factor activity cellular component extracellular region extracellular exosome membrane attack complex biological process complement activation cytolysis regulation of complement activation complement activation, alternative pathway immune response complement activation, classical pathway immune system process innate immune response cellular sodium ion homeostasis sources:amigo / quickgoorthologsspecieshumanmouseentrez730109828ensemblensg00000112936ensmusg00000079105uniprotp10643d3yxf5refseq (mrna)nm_000587nm_001243837refseq (protein)np_000578np_001230766location (ucsc)chr 5: 40.91 – 40.98 mbchr 15: 5.02 – 5.09 mbpubmed searchwikidataview/edit humanview/edit mouse its primary task is to bind the c5bc6 complex together. this junction alters the configuration of the protein molecules, exposing a hydrophobic site on c7 that allows the c7 to insert into the phospholipid bilayer of the pathogen.