pituitary disease pituitary disease a pituitary disease is a disorder primarily affecting the pituitary gland. pituitary diseasepituitaryspecialtyendocrinology table the main disorders involving the pituitary gland are: conditiondirectionhormone acromegalyoverproductiongrowth hormone cushing's diseaseoverproductionadrenocorticotropic hormone growth hormone deficiencyunderproductiongrowth hormone syndrome of inappropriate antidiuretic hormoneoverproductionvasopressin diabetes insipidus (can also be nephrogenic)underproductionvasopressin sheehan syndromeunderproductionany pituitary hormone pickardt-fahlbusch syndromeunderproductionany pituitary hormone, except prolactin, which is increased hyperpituitarism (most commonly pituitary adenoma)overproductionany pituitary hormone hypopituitarismunderproductionany pituitary hormone overproduction or underproduction of a pituitary hormone will affect the respective end-organ. for example, insufficient production (hyposecretion) of thyroid stimulating hormone (tsh) in the pituitary gland will cause hypothyroidism, while overproduction (hypersecretion) of tsh will cause hyperthyroidism. thyroidisms caused by the pituitary gland are less common though, accounting for less than 10% of all hypothyroidism cases and much less than 1% of hyperthyroidism cases.