enophthalmos enophthalmos enophthalmos is a posterior displacement of the eyeball within the orbit. it is due to either enlargement of the bony orbit and/or reduction of the orbital content, this in relation to each other. not to be confused with enophthalmia. enophthalmosspecialtyophthalmology it should not be confused with its opposite, exophthalmos, which is the anterior displacement of the eye. it may be a congenital anomaly, or be acquired as a result of trauma (such as in a blowout fracture of the orbit), horner's syndrome (apparent enophthalmos due to ptosis), marfan syndrome, duane's syndrome, silent sinus syndrome or phthisis bulbi.