mdmb-fubinaca mdmb-fubinaca mdmb-fubinaca (also known as mdmb(n)-bz-f and fub-mdmb) is an indazole-based synthetic cannabinoid that is a potent agonist for the cannabinoid receptors, with ki values of 1.14 nm at cb1 and 0.1228 nm at cb2 and ec50 values of 0.2668 nm at cb1 and 0.1411 nm at cb2, and has been sold online as a designer drug. its benzyl analogue (instead of 4-fluorobenzyl) has been reported to be a potent agonist for the cb1 receptor (ki = 0.14 nm, ec50 = 2.42 nm). the structure of mdmb-fubinaca contains the amino acid 3-methylvaline or tert-leucine methyl ester. mdmb-fubinacalegal statuslegal status ca: schedule ii de: npsg (industrial and scientific use only) uk: class b us: schedule i identifiers iupac name methyl (2s)-2--3,3-dimethylbutanoate cas number1971007-93-8pubchem cid119025665chemspider32741674unii544dr70tn4comptox dashboard (epa)dtxsid501010003 chemical and physical dataformulac22h24fn3o3molar mass397.450 g·mol−13d model (jsmol)interactive image smiles o=c(n(c(oc)=o)c(c)(c)c)c1=nn(cc2=cc=c(f)c=c2)c3=c1c=cc=c3 inchi inchi=1s/c22h24fn3o3/c1-22(2,3)19(21(28)29-4)24-20(27)18-16-7-5-6-8-17(16)26(25-18)13-14-9-11-15(23)12-10-14/h5-12,19h,13h2,1-4h3,(h,24,27)/t19-/m1/s1key:rfcdvehnydvcmu-ljqanchmsa-n side effects there have been a large number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid, mainly in russia and belarus. mdmb-fubinaca was first reported in 2014 and quickly gained a reputation as the most deadly synthetic cannabinoid drug sold by 2015. up to 700 hospitalisations and 25 deaths were initially linked to mdmb-fubinaca in media and government reports, and subsequent testing confirmed that at least 1000 hospitalisations and 40 deaths had occurred as a consequence of intoxication by mdmb-fubinaca as of march 2015. legal status in the united states, mdmb-fubinaca is a schedule i controlled substance. as of october 2015, mdmb-fubinaca is a controlled substance in belarus, russia, and china. in july 2021 it was included in table ii-a of the list of prohibited drugs of portugal.