ice (chemotherapy) ice (chemotherapy) ice in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-hodgkin's lymphoma and hodgkin lymphoma. in case of cd20-positive b cell lymphoid malignancies the ice regimen is often combined today with rituximab. this regimen is then called ice-r or r-ice or rice. -ice regimen consists of: rituximab - an anti-cd20 monoclonal antibody, which is able to kill both normal and malignant cd20-bearing b cells; ifosfamide - an alkylating antineoplastic agent of the oxazafosforine group; carboplatin - a platinum-based antineoplastic drug, also an alkylating antineoplastic agent; etoposide - a topoisomerase inhibitor. dosing regimen drugdosemodedays rituximab375 mg/m2iv infusionday 1 ifosfamide5000 mg/m2iv continuous infusion over 24 hoursday 2 mesna for haemorrhagic cystitis prophylaxis with ifosfamide5000 mg/m2iv continuous infusion over 24 hoursday 2 carboplatinoptimized to get auc = 5 (max. 800 mg)iv infusionday 2 etoposide100 mg/m2iv infusion over 1 hourdays 1-3 filgrastim to shorten the period of neutropenia5 µg/kgs.c.days 5-12 cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with autologous stem-cell transplantation follows (if the patient is considered eligible for hdct and asct).