gamma-amino-beta-hydroxybutyric acid gamma-amino-beta-hydroxybutyric acid γ-amino-β-hydroxybutyric acid (gabob), also known as β-hydroxy-γ-aminobutyric acid (β-hydroxy-gaba), and sold under the brand name gamibetal among others, is an anticonvulsant which is used for the treatment of epilepsy in europe, japan, and mexico. it is a gaba analogue, or an analogue of the neurotransmitter γ-aminobutyric acid (gaba), and has been found to be an endogenous metabolite of gaba. γ-amino-β-hydroxybutyric acidclinical datatrade namesgamibetal, othersother namesbuxamine; buxamina; bussamina; γ-amino-β-hydroxybutyric acid; gabob; β-hydroxy-γ-aminobutyric acid; β-hydroxy-gabaidentifiers iupac name (±)-4-amino-3-hydroxybutanoic acid cas number924-49-2 352-21-6pubchem cid2149chemspider2064unii1zhm019fldkeggd00174chebichebi:16080chemblchembl93515comptox dashboard (epa)dtxsid1045877 echa infocard100.011.916 chemical and physical dataformulac4h9no3molar mass119.120 g·mol−13d model (jsmol)interactive image smiles c(c(cn)o)c(=o)o inchi inchi=1s/c4h9no3/c5-2-3(6)1-4(7)8/h3,6h,1-2,5h2,(h,7,8)key:yqgdepyyfwupgo-uhfffaoysa-n medical uses gabob is an anticonvulsant and is used in the treatment of epilepsy. pharmacology gabob is a gaba receptor agonist. it has two stereoisomers, and shows stereoselectivity in its actions. specifically, (r)-(–)-gabob is a moderate-potency agonist of the gabab receptor, while (s)-(+)-gabob is a partial agonist of the gabab receptor and an agonist of the gabaa receptor. (s)-(+)-gabob is around twice as potent an anticonvulsant as (r)-(–)-gabob. gabob is used medically as a racemic mixture. relative to gaba, gabob has more potent inhibitory effects on the central nervous system, perhaps due to its greater capacity to cross the blood–brain barrier. however, gabob is of relatively low potency as an anticonvulsant when used by itself, and is more useful as an adjuvant treatment used alongside another anticonvulsant. chemistry gabob, or β-hydroxy-gaba, is a close structural analogue of gaba (see gaba analogue), as well as of γ-hydroxybutyric acid (ghb), phenibut (β-phenyl-gaba), baclofen (β-(4-chlorophenyl)-gaba), and pregabalin (β-isobutyl-gaba). society and culture generic name gabob has been referred to by the generic name buxamine or buxamina. brand names gabob is sold primarily under the brand name gamibetal. it has also been marketed under a variety of other brand names including aminoxan, bogil, diastal, gabimex, gabomade, gaboril, gamalate, and kolpo.