estradiol dienantate estradiol dienantate estradiol dienanthate (ede), sold under the brand names climacteron among others, is a long-acting estrogen medication which was previously used in menopausal hormone therapy for women and to suppress lactation in women. it was formulated in combination with estradiol benzoate (eb), a short-acting estrogen, and testosterone enanthate benzilic acid hydrazone (tebh), a long-acting androgen/anabolic steroid. ede has not been made available for medical use alone. the medication, in combination with eb and tebh, was given by injection into muscle once or at regular intervals, for instance once every 6 weeks. not to be confused with estradiol enanthate. estradiol dienantateclinical datatrade namesclimacteron, amenose, lactimex, lactostat (all combinations)other namesestradiol dienantate; ede; eden; e2-edn; estradiol diheptanoate; estra-1,3,5(10)-triene-3,17β-diol 3,17β-diheptanoateroutes ofadministrationintramuscular injectiondrug classestrogen; estrogen esteridentifiers iupac name phenanthren-17-yl] heptanoate cas number7732-97-0pubchem cid165688drugbankdb13955chemspider145199unii65c72p1860echa infocard100.028.903 chemical and physical dataformulac32h48o4molar mass496.732 g·mol−13d model (jsmol)interactive image smiles ccccccc(=o)o1cc21(cc32ccc4=c3c=cc(=c4)oc(=o)cccccc)c inchi inchi=1s/c32h48o4/c1-4-6-8-10-12-30(33)35-24-15-17-25-23(22-24)14-16-27-26(25)20-21-32(3)28(27)18-19-29(32)36-31(34)13-11-9-7-5-2/h15,17,22,26-29h,4-14,16,18-21h2,1-3h3/t26-,27-,28+,29+,32+/m1/s1key:ovahzptywmwnko-cahawpiusa-n side effects of ede include breast tenderness, breast enlargement, nausea, headache, and fluid retention. ede is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. it is an estrogen ester and a prodrug of estradiol in the body. because of this, it is considered to be a natural and bioidentical form of estrogen. ede was first described by 1959. it was previously available in canada and germany but was discontinued by 2005. the medication is no longer available in any form. medical uses ede, a long-acting estrogen, was used in combination with eb, a short-acting estrogen, and tebh, a long-acting androgen/anabolic steroid, in menopausal hormone therapy in perimenopausal, postmenopausal, hypogonadal, and oophorectomized women, as well as for suppression of lactation in postpartum women. available forms