dobrava-belgrade orthohantavirus dobrava-belgrade orthohantavirus dobrava-belgrade orthohantavirus (dobv), also known as dobrava virus, is an enveloped, single-stranded, negative-sense rna virus species of old world orthohantavirus. it is one of several species of hantavirus that is the causative agent of severe hantavirus hemorrhagic fever with renal syndrome. it was first isolated in 1985 from a yellow-necked mouse (apodemus flavicollis) found in the village of dobrava, southeastern slovenia. it was subsequently isolated in striped field mice in russia and other parts of eastern europe. it has also been found in germany but the reservoir host there is unknown. dobrava-belgrade orthohantavirus virus classification (unranked): virus realm: riboviria kingdom: orthornavirae phylum: negarnaviricota class: ellioviricetes order: bunyavirales family: hantaviridae genus: orthohantavirus species: dobrava-belgrade orthohantavirus member viruses dobrava virus kurkino virus saaremaa virus sochi virus synonyms dobrava-belgrade hantavirus dobrava-belgrade virus phylogeny four genotypes are described: dobrava, observed mostly in southeastern europe kurkino, observed throughout northern and eastern europe saaremaa, observed in estonia and slovakia sochi, observed in the black sea coast region of russia disease clinical presentation varies between the four genotypes. dobrava is the most virulent, with a case-fatality rate (cfr) of 10 to 12%, followed by sochi, which has a cfr greater than 6%, then kurkino, which has a cfr 0.3% to 0.9%, and lastly saaremaa, which seems to mainly be subclinical as illness has not been reported despite a relatively high rate of seropositivity. natural reservoir the four genotypes each have their own natural reservoir: dobrava: yellow-necked mouse kurkino: striped field mouse saaremaa: striped field mouse sochi: black sea field mouse