bambuterol bambuterol bambuterol (inn) is a long-acting β adrenoceptor agonist (laba) used in the treatment of asthma; it also is a prodrug of terbutaline. commercially, the astrazeneca pharmaceutical company produces and markets bambuterol as bambec and oxeol. bambuterolbambuterol (top),and (r)-bambuterol (bottom)clinical dataahfs/drugs.cominternational drug namespregnancycategory unknown routes ofadministrationoral (tablets)atc coder03cc12 (who) legal statuslegal status au: s4 (prescription only) in general: ℞ (prescription only) pharmacokinetic databioavailability20%metabolismextensive hepatic.further metabolized to terbutaline by plasma cholinesteraseelimination half-life13 hours (bambuterol)21 hours (terbutaline)excretionrenalidentifiers iupac name (rs)-5-benzene-1,3-diyl bis(dimethylcarbamate) cas number81732-65-2 yhcl: 81732-46-9 ypubchem cid54766iuphar/bps6601drugbankdb01408 nchemspider49466 yuniiy1850g1ovchcl: 786q84qz3f ykeggd07377 ychebichebi:553827 nchemblchembl521589 ycomptox dashboard (epa)dtxsid5048550 chemical and physical dataformulac18h29n3o5molar mass367.446 g·mol−13d model (jsmol)interactive imagechiralityracemic mixture smiles o=c(oc1cc(cc(oc(=o)n(c)c)c1)c(o)cnc(c)(c)c)n(c)c inchi inchi=1s/c18h29n3o5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22h,11h2,1-7h3 ykey:anzxoiakunovqu-uhfffaoysa-n y ny (what is this?) (verify) it is not available in the u.s. indications as other labas, bambuterol is used in the long-term management of persistent asthma. it should not be used as a rescue medication for short-term relief of asthma symptoms. contraindications bambuterol is contraindicated in pregnancy and in people with seriously impaired liver function. it can be used by people with renal impairment, but dose adjustments are necessary. adverse effects the adverse effect profile of bambuterol is similar to that of salbutamol, and may include fatigue, nausea, palpitations, headache, dizziness and tremor. interactions concomitant administration of bambuterol with corticosteroids, diuretics, and xanthine derivatives (such as theophylline) increases the risk of hypokalemia (decreased levels of potassium in the blood). bambuterol acts as a cholinesterase inhibitor, and can prolong the duration of action of suxamethonium (succinylcholine) and other drugs whose breakdown in the body depends on cholinesterase function. butyrylcholinesterase activity returns to normal approximately two weeks after bambuterol is stopped. it can also enhance the effects of non-depolarizing neuromuscular blockers, such as vecuronium bromide.