generalized lentiginosis generalized lentiginosis generalized lentiginosis is a cutaneous condition that will occasionally present without other associated abnormalities.: 686 it may be caused by carney complex, noonan syndrome with multiple lentigines or peutz–jeghers syndrome. generalized lentiginosisother namesfamilial multiple lentigines syndrome without systemic involvementgeneralized lentiginosis is inherited in an autosomal dominant mannerspecialtydermatology