shown to increase frataxin levels in frda cells, mouse models, and humans. dmf showed an 85% increase in frataxin expression over 3 months in multiple sclerosis . frataxin replacements or stabilizers epo mimetics are orally available peptide imitations of erythropoietin. they are small molecules erythropoietin receptor agonists designed to activate the tissue-protective erythropoietin receptor. etravirine, an antiviral drug used to treat hiv, was found in a drug repositioning screening to increase frataxin levels in peripheral cells. fratagene therapeutics is developing a small molecule called rnf126 to inhibit an enzyme which degrades frataxin. increase frataxin gene expression resveratrol might improve mitochondrial function. nicotinamide (vitamin b3) was found effective in preclinical frda models and well tolerated. an rna-based approach might unsilence the fxn gene and increase the expression of frataxin. non-coding rna (ncrna) could be responsible for directing the localized epigenetic silencing of the fxn gene. lentivirus-mediated delivery of the fxn gene has been shown to increase frataxin expression and prevent dna damage in human and mouse fibroblasts. crispr therapeutics received a grant from the friedreich's ataxia research alliance to investigate gene editing as a potential treatment for the disease in 2017. society and culture kyle bryant training on his recumbent bicycle the cake eaters is a 2007 independent drama film that stars kristen stewart as a young woman with frda. the ataxian is a documentary that tells the story of kyle bryant, an athlete with frda who completes a long-distance bike race in an adaptive "trike" to raise money for research. dynah haubert spoke at the 2016 democratic national convention about supporting americans with disabilities. geraint williams in an athlete affected by frda who is known for scaling mount kilimanjaro in an adaptive wheelchair. shobhika kalra is an activist with frda who helped build over 1000 wheelchair ramps across the united arab emirates in 2018 to try to make dubai fully wheelchair-friendly by 2020.