lidoflazine lidoflazine lidoflazine is a piperazine calcium channel blocker. it is a coronary vasodilator with some antiarrhythmic action. lidoflazine was discovered at janssen pharmaceutica in 1964. lidoflazineclinical dataahfs/drugs.cominternational drug namesatc codec08ex01 (who) identifiers iupac name 2-piperazin-1-yl]-n-(2,6-dimethylphenyl)acetamide cas number3416-26-0 ypubchem cid3926chemspider3789 nuniij4zhn3hbtekeggd04733 ycomptox dashboard (epa)dtxsid6045377 echa infocard100.020.285 chemical and physical dataformulac30h35f2n3omolar mass491.627 g·mol−13d model (jsmol)interactive imagemelting point159 to 161 °c (318 to 322 °f)solubility in wateralmost insoluble in water(<0.01%); very soluble in chloroform(>50%); mg/ml (20 °c) smiles cc1=c(c(=cc=c1)c)nc(=o)cn2ccn(cc2)cccc(c3=cc=c(c=c3)f)c4=cc=c(c=c4)f inchi inchi=1s/c30h35f2n3o/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28h,4,7,16-21h2,1-2h3,(h,33,36) nkey:zbiakumoekiltf-uhfffaoysa-n n ny (what is this?) (verify) physical properties solubility at room temperature extracted from solvent 0.01 n 0.1 n % ph % ph hydrochloric acid 0.4 3.0 0.7 1.9 tartaric acid 0.3 3.1 1.0 2.5 citric acid 0.3 3.1 0.5 2.5 lactic acid 0.2 3.4 0.7 2.9 acetic acid 0.1 3.5 0.4 3.8 synthesis compare for ranolazine. thieme patent: alternate preparation of #3: alkylation of n-carbethoxypiperazine (1) with 1--4-fluorobenzene (2) gives cid:12679861 (3). deprotection of which afforded 1-piperazine . acylation of 2,6-xylidine (4) with chloroacetyl chloride (5) gives n-chloroacetyl-2,6-xylidine (6). the convergent synthesis between the above two counterparts completed the synthesis of lidoflazine (7).