meltzer's triad meltzer's triad meltzer's triad describes the classical symptoms suggesting the diagnosis of cryoglobulinaemia of polyclonal cgs seen in essential-, viral-, or connective tissue disease-associated cryoglobulinaemia. the triad consists of: palpable purpura arthralgia (joint pain) weakness. meltzer's triaddifferential diagnosiscryoglobulinaemia