aphalangy-syndactyly-microcephaly syndrome aphalangy-syndactyly-microcephaly syndrome aphalangy-syndactyly-microcephaly syndrome is a very rare limb malformation syndrome which is characterized by agenesis of the distal phalanges (distal aphalangia), syndactyly, duplication of the fourth metatarsal, microcephaly, and mild intellectual disabilities. only 6 cases from 4 families in spain, turkey and other countries have been reported in medical literature. transmission is autosomal dominant. aphalangy-syndactyly-microcephaly syndromespecialtymedical geneticspreventionnoneprognosismediumfrequencyvery rare, only 6 cases have been reported in medical literature.deaths-