pnu-142633 pnu-142633 pnu-142633 is an experimental drug candidate for the treatment of migraine. it exerts its effect as a selective, high affinity 5-ht1d receptor antagonist. pnu-142633 is well tolerated after oral administration. pnu-142633 names preferred iupac name (1s)-1--n-methyl-3,4-dihydro-1h-2-benzopyran-6-carboxamide other names pnu-142633f identifiers cas number 187665-65-2 y249765-69-3 (maleate) y 3d model (jsmol) interactive image chemspider 8020862 pubchem cid 9845148 unii b54p1bq73l yvf98f3655p (maleate) y comptox dashboard (epa) dtxsid00431734 inchi inchi=1s/c24h30n4o3/c1-26-24(30)19-4-7-21-18(16-19)9-15-31-22(21)8-10-27-11-13-28(14-12-27)20-5-2-17(3-6-20)23(25)29/h2-7,16,22h,8-15h2,1h3,(h2,25,29)(h,26,30)/t22-/m0/s1key: pntvccrnjogkga-qfipxvfzsa-ninchi=1/c24h30n4o3/c1-26-24(30)19-4-7-21-18(16-19)9-15-31-22(21)8-10-27-11-13-28(14-12-27)20-5-2-17(3-6-20)23(25)29/h2-7,16,22h,8-15h2,1h3,(h2,25,29)(h,26,30)/t22-/m0/s1key: pntvccrnjogkga-qfipxvfzbb smiles nc(c(c=c1)=cc=c1n2ccn(cc3occc4=c3c=cc(c(nc)=o)=c4)cc2)=o properties chemical formula c24h30n4o3 molar mass 422.529 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references it was an interesting candidate due to its greater affinity for 5-ht1d compared to 5-ht1b receptors (typical migraine drugs such as triptans are agonists for both receptors), but experimental results were disappointing. the structure can be compared favorably with sonepiprazole.