talbutal talbutal talbutal (lotusate) is a barbiturate with a short to intermediate duration of action. it is a structural isomer of butalbital. talbutal is a schedule iii drug in the u.s. talbutalclinical dataother names5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrioneatc coden05ca07 (who) legal statuslegal status ca: schedule iv us: schedule iii identifiers iupac name (rs)-5-allyl-5-sec-butylpyrimidine-2,4,6(1h,3h,5h)-trione cas number115-44-6 ypubchem cid8275drugbankdb00306 ychemspider7976 yunii4yir8202axchemblchembl1200802 ncomptox dashboard (epa)dtxsid8023630 echa infocard100.003.719 chemical and physical dataformulac11h16n2o3molar mass224.260 g·mol−13d model (jsmol)interactive image smiles o=c1nc(=o)nc(=o)c1(c(c)cc)c\c=c inchi inchi=1s/c11h16n2o3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7h,1,5-6h2,2-3h3,(h2,12,13,14,15,16) ykey:bjvvmkuxkqhwjk-uhfffaoysa-n y ny (what is this?) (verify) pharmacology talbutal is a short to intermediate-acting barbiturate. barbiturates act as nonselective depressants of the central nervous system (cns), capable of producing all levels of cns mood alteration from excitation to mild sedation, hypnosis, and deep coma. in sufficiently high therapeutic doses, barbiturates induce anesthesia. mechanism of action talbutal binds at a distinct binding site associated with a cl− ionophore at the gabaa receptor, increasing the duration of time for which the cl− ionophore is open. the post-synaptic inhibitory effect of gaba in the thalamus is, therefore, prolonged. toxicity symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock.