7-nitroindazole 7-nitroindazole 7-nitroindazole, or 7-ni, is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. nitroindazole acts as a selective inhibitor for neuronal nitric oxide synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (no). nitric oxide can diffuse through the plasma membrane into neighbouring cells, allowing cell signalling, so nitroindazole indirectly inhibits this signalling process. other inhibitors exist such as 3-bromo-7-nitroindazole, which is more potent but less specific, or npa (n-propyl-l-arginine), which acts on a different site. 7-nitroindazole names preferred iupac name 7-nitro-1h-indazole identifiers cas number 2942-42-9 y 3d model (jsmol) interactive image chembl chembl247378 y chemspider 1821 y echa infocard 100.019.032 iuphar/bps 5127 pubchem cid 1893 unii ux0n37cmvh y comptox dashboard (epa) dtxsid30183638 inchi inchi=1s/c7h5n3o2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4h,(h,8,9) ykey: pqcauhuktbhusa-uhfffaoysa-n yinchi=1/c7h5n3o2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4h,(h,8,9)key: pqcauhuktbhusa-uhfffaoyae smiles (=o)c1cccc2c1nc2 properties chemical formula c7h5n3o2 molar mass 163.1335 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references pharmacology 7-nitroindazole is under investigation as a possible protective agent against nerve damage caused by excitotoxicity or neurodegenerative diseases. it may act by reducing oxidative stress or by decreasing the amount of peroxynitrite formed in these tissues. these effects are related to the inhibition of type 1 nitric oxide synthase. however, anticonvulsive effect is derived from some other mechanisms.