bicifadine bicifadine bicifadine (dov-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (sndri) discovered at american cyanamid as an analgesic drug candidate, and licensed to dov pharmaceutical in 1998 after american cyanamid was acquired by wyeth. bicifadineclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status us: unscheduled pharmacokinetic dataelimination half-life1.6 hoursexcretionrenalidentifiers iupac name 1-(4-methylphenyl)-3-azabicyclohexane cas number71195-57-8 ypubchem cid47953chemspider9889978 yuniib0sv3n7j3hchemblchembl511099 necha infocard100.124.957 chemical and physical dataformulac12h15nmolar mass173.259 g·mol−13d model (jsmol)interactive image smiles c1cc(ccc1c)32cnc2c3 inchi inchi=1s/c12h15n/c1-9-2-4-10(5-3-9)12-6-11(12)7-13-8-12/h2-5,11,13h,6-8h2,1h3/t11-,12+/m0/s1 ykey:ofyvigtwsqpclf-nwdgafqwsa-n y ny (what is this?) (verify) in january 2007, dov licensed the rights to bicifadine to xtl biopharmaceuticals after bicifadine failed in a phase iii clinical trial for chronic lower back pain. xtl ran a phaseiib clinical trial for pain caused by diabetic neuropathy, which failed in 2008; xtl terminated the agreement in 2010. in 2010 dov was acquired by euthymics bioscience which intended to continue development of other candidates from dov's portfolio. bicifadine has a non-opioid, non-nsaid mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than nsaid drugs. while the drug is purported to be a serotonin (sert) and noradrenaline transporter (net) inhibitor, it also has effects at the dopamine transporter (dat), effectively making it a broad-spectrum monoamine transporter inhibitor or "triple reuptake inhibitor."