jwh-164 jwh-164 jwh-164 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. it has approximately equal affinity for the cb1 and cb2 receptors, with a ki of 6.6 nm at cb1 and 6.9 nm at cb2. jwh-164 is a positional isomer of the related compound jwh-081, but with a methoxy group at the 7-position of the naphthyl ring, rather than the 4-position as in jwh-081. its potency is intermediate between that of jwh-081 and its ring unsubstituted derivative jwh-018, demonstrating that substitution of the naphthyl 7-position can also result in increased cannabinoid receptor binding affinity. jwh-164legal statuslegal status us: schedule i identifiers iupac name 7-methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone cas number824961-61-7 ypubchem cid45271217chemspider24618407uniil3432l6cjjcomptox dashboard (epa)dtxsid70669880 chemical and physical dataformulac25h25no2molar mass371.480 g·mol−13d model (jsmol)interactive image smiles cccccn(c4)c1ccccc1c4c(=o)c2cccc(cc3)c2cc3oc inchi inchi=1s/c25h25no2/c1-3-4-7-15-26-17-23(20-10-5-6-12-24(20)26)25(27)21-11-8-9-18-13-14-19(28-2)16-22(18)21/h5-6,8-14,16-17h,3-4,7,15h2,1-2h3key:ijnszbaevyrfch-uhfffaoysa-n (verify) in the united states, all cb1 all receptor agonists of the 3-(1-naphthoyl)indole class, including jwh-164, are schedule i controlled substances.