way-214156 way-214156 way-214156 is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the erβ. it is 100-fold selective for the erβ over the erα with an ic50 of 4.2 nm (compare to estradiol with ic50 values of ~3–4 nm for both the erα and erβ). the drug is less selective for the erβ than is prinaberel (erb-041, way-202041), another selective erβ agonist, but is more potent in comparison. way-214156 may produce anti-inflammatory effects via the erβ and has been proposed as a potential treatment for inflammatory conditions such as rheumatoid arthritis. way-214156identifiers iupac name 2,8-dihydroxy-6h-dibenzochromene-4,12-dicarbonitrile pubchem cid11358924chemspider9533851chemical and physical dataformulac19h10n2o3molar mass314.300 g·mol−13d model (jsmol)interactive image smiles c1c2=c(c=cc(=c2)o)c3=c(o1)c4=c(c=c(c=c4c#n)o)c(=c3)c#n inchi inchi=1s/c19h10n2o3/c20-7-10-5-17-15-2-1-13(22)4-12(15)9-24-19(17)18-11(8-21)3-14(23)6-16(10)18/h1-6,22-23h,9h2key:ugzyfajttrgnox-uhfffaoysa-n