abt-436 abt-436 abt-436 is an orally active, highly selective vasopressin v1b receptor antagonist which was under development by abbott laboratories and abbvie for the treatment of major depressive disorder, anxiety disorders, and alcoholism but was discontinued. it reached phase ii clinical trials prior to the discontinuation of its development. abt-436clinical dataroutes ofadministrationby mouthidentifierscas number1642328-87-7 yuniiu6sir21grb