chronotherapy (treatment scheduling) chronotherapy (treatment scheduling) chronotherapy, also called chronotherapeutics or chronotherapeutic drug delivery, refers to the coordination of therapeutic treatments with an individual's circadian or other rhythmic cycles. this may be done to maximize effectiveness of a specific treatment, minimize possible side effects, or both. "chronotherapy" redirects here. for other uses, see chronotherapy (sleep phase). chronotherapy (treatment scheduling)meshd019454 in the treatment of psychiatric conditions including bipolar depression, a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.