mg132 mg132 mg132 is a potent, reversible, and cell-permeable proteasome inhibitor (ki = 4 nm). it belongs to the class of synthetic peptide aldehydes. it reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26s complex without affecting its atpase or isopeptidase activities. mg132 activates c-jun n-terminal kinase (jnk1), which initiates apoptosis. mg132 also inhibits nf-κb activation with an ic50 of 3 μm and prevents β-secretase cleavage. mg132 names systematic iupac name benzyl amino}-1-oxopentan-2-yl]amino}-1-oxopentan-2-yl]carbamate other names n-benzyloxycarbonyl-l-leucyl-l-leucyl-l-leucinalz-leu-leu-leu-al identifiers cas number 133407-82-6 y 3d model (jsmol) interactive image chemspider 406728 n pubchem cid 462382 unii rf1p63gw3k y comptox dashboard (epa) dtxsid3042639 inchi inchi=1s/c26h41n3o5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23h,12-14,16h2,1-6h3,(h,27,31)(h,28,32)(h,29,33)/t21-,22-,23-/m0/s1 nkey: tzywcyjvhrluct-vabkmulxsa-n n smiles cc(c)c(c=o)nc(=o)(cc(c)c)nc(=o)(cc(c)c)nc(=o)occ1ccccc1 properties chemical formula c26h41n3o5 molar mass 475.630 g·mol−1 appearance white solid solubility 100 mm in etoh and dmso except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references molecular mechanism there are several inhibitors that can readily enter cell and selectively inhibit degradative pathway. it includes peptide aldehydes, such as cbz-leu-leu-leucinal (mg132), cbz-leu-leu-norvalinal (mg115) and acetyl-leu-leu-norleucinal (alln). these are substrate analogues and potent transition-state inhibitors of chymotrypsin like activity of proteasome machinery. the peptide aldehydes are also known to inhibit certain lysosomal cysteine proteases and the calpains hence mg132 may not be exclusive inhibitor of proteasomal pathway.