tezampanel tezampanel tezampanel (inn, usan) (code names ly-293,558, ngx-424) is a drug originally developed by eli lilly which acts as a competitive antagonist of the ampa and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the glur5 subtype of the kainate receptor. it has neuroprotective and anticonvulsant properties, the former of which may, at least in part, occur via blockade of calcium uptake into neurons. tezampanelclinical dataroutes ofadministrationivatc codenonelegal statuslegal status investigational identifiers iupac name (3s,4ar,6r,8ar)-6-decahydroisoquinoline-3-carboxylic acid cas number154652-83-2 ypubchem cid127894iuphar/bps4245chemspider113428 nuniiga36s2o9c2keggd06656 nchemblchembl14935 nchemical and physical dataformulac13h21n5o2molar mass279.344 g·mol−13d model (jsmol)interactive image smiles c1c2cn(c2c1ccc3=nnn=n3)c(=o)o inchi inchi=1s/c13h21n5o2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14h,1-7h2,(h,19,20)(h,15,16,17,18)/t8-,9+,10-,11+/m1/s1 nkey:zxfrfpszaknpqq-ytwajwbksa-n n ny (what is this?) (verify) tezampanel has a range of effects which may be useful for medicinal purposes, as well as its applications in scientific research. it suppresses both the withdrawal symptoms from morphine and other opioids, and the development of tolerance, as well as having antihyperalgesic and analgesic effects in its own right. it also has anxiolytic effects in animal studies and has been suggested as a candidate for the treatment of anxiety in humans.