medrysone medrysone medrysone (inn, usan) (brand names hms, medrocort, others; former developmental code name nsc-63278), also known as hydroxymethylprogesterone, methylhydroxyprogesterone, or hydroxymesterone, as well as 6α-methyl-11β-hydroxyprogesterone or 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases. it has been discontinued in the united states. although it is very similar in structure to progesterone, neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone. medrysoneclinical datatrade nameshms, medrocort, othersother namesnsc-63278; hydroxymethylprogesterone; methylhydroxyprogesterone; hydroxymesterone; 6α-methyl-11β-hydroxyprogesterone; 6α-methyl-11β-hydroxypregn-4-ene-3,20-dioneahfs/drugs.commicromedex detailed consumer informationmedlineplusa606003routes ofadministrationeye dropsatc codes01ba08 (who) legal statuslegal status us: discontinued identifiers iupac name (6s,8s,9s,10r,11s,13r,14s,17s)- 17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17- dodecahydrocyclopenta phenanthren-3-one cas number2668-66-8 ypubchem cid247839iuphar/bps7086drugbankdb00253 nchemspider216968 nuniid2ufc189xfkeggd02289 ychemblchembl1201173 ncomptox dashboard (epa)dtxsid6045371 echa infocard100.018.371 chemical and physical dataformulac22h32o3molar mass344.495 g·mol−13d model (jsmol)interactive image smiles c1c23cc(3(c(24(c1=cc(=o)cc4)c)o)c)c(=o)c inchi inchi=1s/c22h32o3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25h,5-9,11h2,1-4h3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1 nkey:gzenksodflbbhq-ilszzqpisa-n n ny (what is this?) (verify) environmental presence in 2021, medrysone was one of the 12 compounds identified in sludge samples taken from 12 wastewater treatment plants in california that were associated with estrogenic activity in in vitro.