incyclinide incyclinide incyclinide (proposed trade name metastat) is a chemically modified tetracycline antibiotic that was investigated in clinical trials for the treatment of rosacea, various tumours, allergic and inflammatory diseases and a number of other conditions. incyclinideclinical datatrade namesmetastat (proposed)atc codenonelegal statuslegal status abandoned? identifiers iupac name (4as,5ar,12as)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydronaphthacen-2-carboxamide cas number15866-90-7pubchem cid54678924chemspider28530521unii21g64wzq4ikeggd04519chemblchembl2104970chemical and physical dataformulac19h17no7molar mass371.345 g·mol−13d model (jsmol)interactive image smiles c1cc2c(c(c1)o)c(=o)c3=c(4((c3c2)cc(=c(c4=o)c(=o)n)o)o)o inchi inchi=1s/c19h17no7/c20-18(26)14-11(22)6-9-5-8-4-7-2-1-3-10(21)12(7)15(23)13(8)16(24)19(9,27)17(14)25/h1-3,8-9,21-22,24,27h,4-6h2,(h2,20,26)/t8-,9-,19-/m0/s1key:zxfcrfyuluusdw-owxodzswsa-n data from animal studies suggest that centrally infused incyclinide attenuates microglial mediated neuroinflammation in the paraventricular nucleus of the hypothalamus and sympathetic activation in angiotensin ii-induced hypertension. this was also associated with unique changes in gut microbial communities and profound attenuation of gut pathology in animal models of hypertension. mechanism of action like other tetracyclines, incyclinide inhibits matrix metalloproteinases. in contrast to traditional tetracyclines, it lacks antibiotic properties.