tropical theileriosis tropical theileriosis tropical theileriosis or mediterranean theileriosis is a theileriosis of cattle from the mediterranean and middle east area, from morocco to western parts of india and china. it is a tick-borne disease, caused by theileria annulata. the vectors are ticks of the genera hyalomma and rhipicephalus. tropical theileriosis scientific classification domain: eukaryota clade: diaphoretickes clade: sar clade: alveolata phylum: apicomplexa class: aconoidasida order: piroplasmida family: theileriidae genus: theileria species: t. annulata binomial name theileria annulata the most prominent symptoms are fever and lymph node enlargement. but there is a wide range of clinical manifestations, especially in enzootic areas. among them, the doukkala area of morocco, where the epidemiology and symptomatology of the disease were minutely studied. the disease was once considered as "benign" in the literature, in comparison to east coast fever. with the introduction of european breeds into the region, however, it could become of major economic incidence. an efficient treatment with parvaquone, then buparvaquone became available in many countries from the mid-1990s. animals native to endemic areas appear more tolerant to the disease, buffalos especially, appear less susceptible. clinical signs a high temperature (41.2 °c (106.2 °f)) is a common feature in acute cases. body temperature is regularly higher than in any other cattle disease. fever from 41 to 42 °c (106 to 108 °f) is common in acute stages. later on (day 5 to day 10 from the clinical onset), temperature will lower to a normal range (38.0–39.5 °c (100.4–103.1 °f)), but the disease will continue to progress, despite a possible apparent clinical improvement (appetite comes back). afterwards, from d10 to d15, there is a downfall stage, with hypothermia (37 to 38 °c (99 to 100 °f)), anemia, jaundice, and heart failure. such animals rarely recover, even with intensive treatment. lymph nodes are commonly enlarged and there may be episodes of blood from the nose, difficulty breathing and weight loss. other signs, but not present in all cases are : blood-tinged diarrhea, or with obvious blood clots. bruxism(grinding of teeth) can be seen circular raised patches of hair all over the body haemorrhages in the ocular and vaginal mucous membranes a degree of anaemia diarrhea with blood clots in a calf diagnosis lymph node enlargement in six-months-old calves in asymptomatic infestation lymph node enlargement and even hyperthermia can occur asymptomatically in enzootic area, during the disease season. clinical signs, including lymph node enlargement, anaemia, hyperthermia and history of tick infestation can lead to a suspicion of theileriosis definitive diagnosis relies on the observation of the pirolplasm stages of the organism in the erythrocytes in blood smears stained with romanowsky stains. lymph node aspirates can also be examined for the presence of 'kock's blue bodies' which are schizont stages in lymphocytes. necropsy reveals 'punched out ulcers' in the abomasum and greyish raised 'infarcts' on kidneys. numerous serological tests like elisa, and indirect immunofluorescence test and pcr can also help diagnosis. theileria-annulata-piroplasms-cattle treatment and control buparvaquone, halofuginone and tetracycline and butalex and oxytetracycline have all shown to be effective. tick control should be considered, but resistance to parasiticide products may be increasing. there are various options for controlling ticks of domestic animals, including: topical application of parasiticidal chemicals in dip baths or spray races or pour-on formulations, spraying parasiticides on walls of cattle pens, and rendering the walls of cattle pens smooth with mortar to stop ticks molting there. selection of cattle for good ability to acquire immune resistance to ticks is potentially effective. endemic stability is a state where animals are affected at a low levels or not as susceptible to the disease, and this may be encouraged in endemic areas. vaccination is available and should be performed in breeds that are susceptible to infection. live attenuated vaccine are being used in many countries like india, iran, turkey etc. which is a basically a lymphocyte infected with t. annulata schizont stage and passaged for attenuation. vectors hyalomma marginatum marginatum is by far the most common vector in the extremadura region of spain. the habela team investigated several locations across the 1990s and collected their analysis in habela et al 1999. they found hmm very prevalently but also commonly found rhipicephalus bursa, and rb is most common in cattle and cattle suffer the worst. h. lusitanicum and r. sanguineus are rare. range this is the most impactful tick-borne disease in the extremadura region of spain. the habela team found mediterranean theileriosis consistently in several studies throughout the 1990s, collected in their habela et al 1999.: 227