laugier–hunziker syndrome laugier–hunziker syndrome laugier–hunziker syndrome (/ˈloʊʒieɪ ˈhʊntsɪkər/) is a cutaneous condition characterized by hyperpigmentation of the oral mucosa, longitudinal melanonychia, and genital melanosis. laugier–hunziker syndromespecialtydermatology the hyperpigmentation presented in laugier-hunziker syndrome is benign and should be differentiated from peutz-jeghers syndrome.