sorbinil sorbinil sorbinil (inn) is an aldose reductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy. aldose reductase is an enzyme present in lens and brain that removes excess glucose by converting it to sorbitol. sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. sorbinil has been shown to inhibit aldose reductase in human brain and placenta and calf and rat lens. sorbinil reduced sorbitol accumulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25 mg/kg sorbinil. sorbinil names preferred iupac name (4s)-6-fluoro-2,3-dihydrospirobenzopyran-4,4′-imidazolidine]-2,5-dione other names (s)-6-fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione; cp 45634 identifiers cas number 68367-52-2 3d model (jsmol) interactive image chembl chembl7681 chemspider 298991 echa infocard 100.210.173 iuphar/bps 7415 kegg d05893 pubchem cid 337359 unii g4186b906p y comptox dashboard (epa) dtxsid0023587 inchi inchi=1s/c11h9fn2o3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5h,3-4h2,(h2,13,14,15,16)/t11-/m0/s1 smiles fc3ccc2occ1(c(=o)nc(=o)n1)c2c3 properties chemical formula c11h9fn2o3 molar mass 236.202 g·mol−1 appearance white to off-white powder except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references