is carried out by a bunch of short non-coding rnas. the short non-coding rna interacts with protein argonaute to degrade retrotransposon transcripts and change their dna histone structure to reduce their transcription. role in evolution ltr retrotransposons came about later than non-ltr retrotransposons, possibly from an ancestral non-ltr retrotransposon acquiring an integrase from a dna transposon. retroviruses gained additional properties to their virus envelopes by taking the relevant genes from other viruses using the power of ltr retrotransposon. due to their retrotransposition mechanism, retrotransposons amplify in number quickly, composing 40% of the human genome. the insertion rates for line1, alu and sva elements are 1/200 – 1/20, 1/20 and 1/900 respectively. the line1 insertion rates have varied a lot over the past 35 million years, so they indicate points in genome evolution. notably a large number of 100 kilobases in the maize genome show variety due to the presence or absence of retrotransposons. however since maize is unusual genetically as compared to other plants it cannot be used to predict retrotransposition in other plants. mutations caused by retrotransposons include: gene inactivation changing gene regulation changing gene products acting as dna repair sites role in biotechnology