homatropine homatropine homatropine (equipin, isopto homatropine) is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. it is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). homatropineclinical dataahfs/drugs.commonographmedlineplusa601006atc codea02bx03 (who) s01fa05 (who)legal statuslegal status rx only, not fda approved, only sold in uk identifiers iupac name (n-methyl-8-azabicyclooct-3-yl) 2-hydroxy-2-phenylacetate cas number87-00-3 npubchem cid6321423drugbankdb00725 nchemspider16498795 yunii8qs6wcl55zchemblchembl1233442 ncomptox dashboard (epa)dtxsid6044014 echa infocard100.001.561 chemical and physical dataformulac16h21no3molar mass275.348 g·mol−13d model (jsmol)interactive image smiles cn31cc3c(c1)oc(=o)c(o)c2ccccc2 inchi inchi=1s/c16h21no3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18h,7-10h2,1h3/t12-,13+,14+,15? ykey:ztvikzxzylevol-mcoxgkprsa-n y ny (what is this?) (verify) the related chemical compound homatropine methylbromide (methylhomatropine) is a different medication. homatropine is less potent than atropine and has a shorter duration of action. it is available as the hydrobromide salt. homatropine is also given as an atropine substitute given to reverse the muscarinic and cns effects associated with indirect cholinomimetic (anti-achase) administration. it is on the world health organization's list of essential medicines. side effects blurred vision sensitivity to light contraindications untreated glaucoma myasthenia gravis severe heart failure thyrotoxicosis