miu/ml. ammenorhea ranged from 9 to 13 months. in addition, there is strong evidence that continuous micronized dhea 25 mg tid reduces miscarriage and aneuploidy rates, especially above age 35. a combined pentoxifylline-tocopherol treatment has been reported effective in improving uterine parameters in women with pof undergoing ivf with donor oocytes (ivf-od). three women with uterine hormonoresistance despite high estradiol (e2) plasma levels received treatment with 800 mg pentoxifylline and 1000 iu of vitamin e for at least nine months. three frozen-thawed embryo transfers (ets) resulted in two viable pregnancies. mean endometrial thickness increased from 4.9 mm (with thin uterine crosses) to 7.4 mm with nice uterine crosses. this treatment protocol has also reversed some cases of iatrogenic pof caused by full body radiation treatment. research while the primary cause of the end to menstrual cycles is the exhaustion of ovarian follicles, there is some evidence that a defect in the hypothalamus is critical in the transition from regular to irregular cycles. this is supported by at least one study in which transplantation of ovaries from old rats to young ovariectomized rats resulted in follicular development and ovulation. also, electrical stimulation of the hypothalamus is capable of restoring reproductive function in aged animals. due to the complex interrelationship among the hypothalamus, pituitary and ovaries (hpo axis) defects in the functioning of one level can cause defects on the other levels.