quisqualamine quisqualamine quisqualamine is the α-decarboxylated analogue of quisqualic acid, as well as a relative of the neurotransmitters glutamate and γ-aminobutyric acid (gaba). α-decarboxylation of excitatory amino acids can produce derivatives with inhibitory effects. indeed, unlike quisqualic acid, quisqualamine has central depressant and neuroprotective properties and appears to act predominantly as an agonist of the gabaa receptor and also to a lesser extent as an agonist of the glycine receptor, due to the facts that its actions are inhibited in vitro by gabaa antagonists like bicuculline and picrotoxin and by the glycine antagonist strychnine, respectively. mg2+ and dl-ap5, nmda receptor blockers, cnqx, an antagonist of both the ampa and kainate receptors, and 2-hydroxysaclofen, a gabab receptor antagonist, do not affect quisqualamine's actions in vitro, suggesting that it does not directly affect the ionotropic glutamate receptors or the gabab receptor in any way. whether it binds to and acts upon any of the metabotropic glutamate receptors like its analogue quisqualic acid however is unclear. quisqualamine names iupac name 2-(2-aminoethyl)-1,2,4-oxadiazolidine-3,5-dione identifiers cas number 68373-11-5 y 3d model (jsmol) interactive image chemspider 2342291 pubchem cid 3085372 unii pj4rw6n4ea y comptox dashboard (epa) dtxsid60218503 inchi inchi=1s/c4h7n3o3/c5-1-2-7-3(8)6-4(9)10-7/h1-2,5h2,(h,6,8,9)key: lipcxbvxqufcsc-uhfffaoysa-ninchi=1/c4h7n3o3/c5-1-2-7-3(8)6-4(9)10-7/h1-2,5h2,(h,6,8,9)key: lipcxbvxqufcsc-uhfffaoyaa smiles o=c1nc(=o)on1ccn properties chemical formula c4h7n3o3 molar mass 145.118 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references