methazolamide methazolamide methazolamide (trade name neptazane) is a potent carbonic anhydrase inhibitor. it is indicated in the treatment of increased intraocular pressure (iop) in chronic open-angle glaucoma and secondary glaucoma. also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the iop is desired before surgery. not to be confused with methimazole, metamizole, or acetazolamide. methazolamideclinical dataother namesn-(3-methyl-5-sulfamoyl-3h-1,3,4-thiadiazol-2-ylidene) ethanamideahfs/drugs.commonographmedlineplusa601233routes ofadministrationoralatc codes01ec05 (who) legal statuslegal status us: ℞-only pharmacokinetic dataprotein binding~55%elimination half-life~14 hoursidentifiers iupac name n-acetamide cas number554-57-4 ypubchem cid4100iuphar/bps6828drugbankdb00703 ychemspider3958 yuniiw733b0s9sdkeggd00655 nchemblchembl19 ncomptox dashboard (epa)dtxsid1023281 echa infocard100.008.243 chemical and physical dataformulac5h8n4o3s2molar mass236.26 g·mol−13d model (jsmol)interactive image smiles o=s(=o)(c\1=n\n(c(=n/c(=o)c)/s/1)c)n inchi inchi=1s/c5h8n4o3s2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2h3,(h2,6,11,12)/b7-4- ykey:flosmhqxbmrnhr-daxskmnvsa-n y ny (what is this?) (verify) this drug has displayed teratogenic effects in rats. compared to another drug in the same class, acetazolamide, methazolamide requires a lower dose when administered to patients.