sisomicin sisomicin sisomicin (bactoceaze, ensamycin, and initially antibiotic 6640 and rickamicin), is an aminoglycoside antibiotic, isolated from the fermentation broth of micromonospora inositola. it is a newer broad-spectrum aminoglycoside most structurally related to gentamicin. sisomicinclinical datatrade namesbaymicin, bactoceazeahfs/drugs.cominternational drug namesroutes ofadministrationtopicalatc codej01gb08 (who) legal statuslegal status in general: ℞ (prescription only) identifiers iupac name (2r,3r,4r,5r)-2--2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol cas number32385-11-8 npubchem cid36119chemspider33222 nuniix55xsl74yqkeggd02544 ychebichebi:9169 nchemblchembl221886 ncomptox dashboard (epa)dtxsid0023583 echa infocard100.046.365 chemical and physical dataformulac19h37n5o7molar mass447.533 g·mol−13d model (jsmol)interactive image smiles c1(co((1nc)o)o2(c((2o)o3(cc=c(o3)cn)n)n)n)o inchi inchi=1s/c19h37n5o7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h3,9-18,24-27h,4-7,20-23h2,1-2h3/t9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+/m1/s1 nkey:urwajwiaipfpje-yfmiwbnjsa-n n ny (what is this?) (verify) sisomicin is the most predictably active aminoglycoside against gram-positive bacteria. like most other aminoglycosides, sisomicin is bactericidal for sensitive clinical isolates. the minimum bactericidal concentrations (mbc) have been found to be equivalent or very close to the minimum inhibitory concentrations (mic). like other aminoglycosides, most clinical isolates of pseudomonas aeruginosa remain susceptible to sisomicin. resistance to sisomicin may be enzymatically or non-enzymatically mediated. sisomicin is inactivated by the same enzymes as gentamicin, but it is active against many organisms that resist gentamicin by non-enzymatic mechanisms. some studies show that sisomicin has been effective in the treatment of infections that either had failed to respond to other drugs or were due to microorganisms resistant in vitro to other aminoglycosides.