pegol pegol pegol is a term used in generic names for pharmaceutical drugs to indicate the presence of a polyethylene glycol attachment (pegylation). the term is used for monoclonal antibodies and engineered proteins as well as for small molecules. the purpose of the pegylation is to extend the half-life of the drug. examples include: alacizumab pegol calaspargase pegol certolizumab pegol etirinotecan pegol lulizumab pegol