metergoline metergoline metergoline (inn, ban), also known as methergoline and sold under the brand names contralac (veterinary) and liserdol (clinical), is a monoaminergic medication of the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) and to suppress lactation. metergolineclinical datatrade namescontralac, liserdolother namesmethergoline; fi-6337; carbamic acid phenylmethyl esterroutes ofadministrationoralatc codeg02cb05 (who) legal statuslegal status in general: ℞ (prescription only) identifiers iupac name benzyl n-quinolin-9-yl]methyl]carbamate cas number17692-51-2 npubchem cid28693iuphar/bps133chemspider26687 yunii1501393ly5chebichebi:64216chemblchembl19215 ycomptox dashboard (epa)dtxsid5042584 echa infocard100.037.881 chemical and physical dataformulac25h29n3o2molar mass403.526 g·mol−13d model (jsmol)interactive image smiles o=c(occ1ccccc1)nc3c4c5cccc2c5c(cn2c)c4n(c3)c inchi inchi=1s/c25h29n3o2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23h,11-14,16h2,1-2h3,(h,26,29)/t18-,21+,23+/m0/s1 ykey:wzhjkeuhnjhdls-qtgunekasa-n y ny (what is this?) (verify) pharmacology pharmacodynamics metergoline is a ligand of various serotonin and dopamine receptors. activities of metergoline at various sites site affinity (ki ) efficacy (emax ) action 5-ht1a 4.3 ? agonist 5-ht1b 5.2–36 ? partial agonist 5-ht1d 0.60–11.7 ? partial agonist 5-ht1e 776–1,122 ? ? 5-ht1f 339–341 ? ? 5-ht2a 0.12–2.3 ? antagonist 5-ht2b 0.71–1.8 ? antagonist 5-ht2c 0.18–1.8 ? antagonist 5-ht3 >5,000–7,400 ? ? 5-ht4 354 ? ? 5-ht5a 630 ? ? 5-ht5b 1,000 ? ? 5-ht6 61–400 ? ? 5-ht7 6.4–6.5 ? antagonist d2 ? ? agonist notes: all sites are human except 5-ht3 (rat/pig), 5-ht4 (pig), and 5-ht5b (rat—no human counterpart).