jessie stevenson kovalenko medal jessie stevenson kovalenko medal the jessie stevenson kovalenko medal is awarded every two years by the us national academy of sciences "for important contributions to the medical sciences." it was first awarded in 1952 and involves a prize of $25,000 plus $50,000 for research. the kovalenko fund was donated by michael s. kovalenko in 1949 to the national academy of sciences in memory of his wife, jessie stevenson kovalenko. recipients recipient year achievement/rationale katalin kariko drew weissman2022for their pioneering work in developing nucleoside-modified mrna, the foundation for the first two approved covid-19 vaccines. bert vogelstein2020for his pioneering work in elucidating the fundamental principles of the molecular basis of human cancer and the application of this knowledge to improve the clinical management of patients. james p. allison2018for important medical discoveries related to the body’s immune response to tumors. huda y. zoghbi2016for her pioneering contributions to the fields of neurodegenerative proteinopathies, autism spectrum disorders, epigenetics, and developmental biology by coupling clinical observation and gene discovery with focused, in-depth mechanistic study. stuart h. orkin2013for his pioneering achievements in defining the molecular basis of blood disorders and the mechanisms governing the development of blood stem cells and individual blood lineages. his work has significantly advanced our understanding of human hematologic diseases and revealed new strategies to prevent and manage these disorders. janet d. rowley2010for her discovery of recurring chromosome translocations that characterize specific hematological malignancies, a landmark event that caused a major shift in the paradigms relating to cancer biology in the 1970s and paved the way for development of specific treatment for two leukemias. jeffrey m. friedman2007for the discovery of leptin and its role in the regulation of appetite, energy expenditure, and the molecular mechanisms underlying obesity. irving l. weissman2004for his seminal studies that defined the physical properties, purification, and growth regulation of multipotent hematopoietic stem cells. robert j. lefkowitz2001for his elucidation of the structure, function, and mechanism of regulation of heptahelical receptors, nature's detectors of signals from many hormones, neurotransmitters, and drugs. hugh o. mcdevitt1998for his landmark discovery and identification of genes that control immune responsiveness, and for his subsequent elucidation of mechanisms of antigen recognition and induction of the immune response. donald metcalf1994for his discovery and purification of the hemotopoietic growth factors and for their introduction into clinical medicine for the control of blood cell formation and resistance to infection. roscoe o. brady1991for revolutionary accomplishments in human sphingolipid storage disorders, including the discovery of enzymatic defects, the development of genetic counseling procedures, and successful enzyme-replacement therapy. maclyn mccarty1988for the discovery and characterization, with avery and mcleod, that deoxyribonucleic acid is the chemical substance of heredity, and for his subsequent contributions to our understanding of the biology of streptococci and their role in disease. oscar d. ratnoff1985for his studies of the hageman trait, an experiment of nature that improved understanding of such bodily defenses as the formation and dissolution of blood clots, inflammation, and immunity. henry g. kunkel1979for his pioneering and influential studies in basic immunology, immune complex disease, immune deficiency disorders, and lymphocytic membrane markers. julius h. comroe, jr.1976for his immeasurable contribution to the diagnosis and treatment of human disease during his career, which was devoted to the physiology and chemistry of respiration and the mechanical and chemical properties of the human lung. seymour s. kety1973for furthering the essential understanding of balance between hereditary and other biological factors, on the one hand, and psychosocial experimental ones, on the other, in the pathogenesis and manifestations of schizophrenia. thomas francis, jr.1970for his laboratory and epidemiological researches on virus diseases, including his major role in the program for the evaluation of the polio vaccine and for his imaginative design for long-term studies of the atomic bomb survivors in japan. karl paul link1967for his discovery and application of coumarin anticoagulants. rufus cole1966for his notable role in advancing our knowledge of lobar pneumonia and in establishing clinical investigation as a science. george h. whipple1962for his contributions of many biological discoveries basic for advances in clinical and experimental medicine. karl f. meyer1961for his outstanding contributions to medical sciences as an investigator, teacher, and administrator over a period of half a century. eugene l. opie1959for his outstanding contributions to medical science and for a life of exemplary devotion to medical education and inquiry into the origins of disease. ernest w. goodpasture1958for his outstanding contributions to medical science and for long and continued devotion to the study of his chosen field of pathology. peyton rous1955 alfred n. richards1952for his outstanding contributions to medical science over a period of a half-century, both as an investigator and as a research executive and administrator.