hu-210 hu-210 hu-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1r,5s)-myrtenol by a group led by raphael mechoulam at the hebrew university. hu-210 is 100 to 800 times more potent than natural thc from cannabis and has an extended duration of action. hu-210 has a binding affinity of 0.061nm at cb1 and 0.52nm at cb2 in cloned human cannabinoid receptors compared to delta-9-thc of 40.7nm at cb1. hu-210 is the (–)-1,1-dimethylheptyl analog of 11-hydroxy- δ8- tetrahydrocannabinol; in some references it is called 1,1-dimethylheptyl- 11-hydroxytetrahydrocannabinol. the abbreviation "hu" stands for hebrew university. hu-210clinical dataother names1,1-dimethylheptyl- 11-hydroxy- tetrahydrocannabinollegal statuslegal status ca: schedule ii uk: class b us: unscheduled identifiers iupac name (6ar,10ar)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6h,6ah,7h,10h,10ah-benzoisochromen-1-ol cas number112830-95-2 ypubchem cid9821569iuphar/bps731chemspider7997318 nunii191042422pchemblchembl307696 ncomptox dashboard (epa)dtxsid30150188 chemical and physical dataformulac25h38o3molar mass386.576 g·mol−13d model (jsmol)interactive image smiles ccccccc(c)(c)c1=cc2=c(3cc(=cc3c(o2)(c)c)co)c(=c1)o inchi inchi=1s/c25h38o3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27h,6-9,11-13,16h2,1-5h3/t19-,20-/m1/s1 nkey:ssqjfgmezbfmnv-wojbjxkfsa-n n ny (what is this?) (verify) effects and research hu-210, the (–) enantiomer of 11-oh-d8-thc-dmh, has almost all of the cannabinoid activity, while the (+) enantiomer, known as hu-211, is inactive as a cannabinoid and instead acts as an nmda antagonist having neuroprotective effects. hu-210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal neural stem and progenitor cells likely via a sequential activation of cb1 receptors, gi/o proteins, and erk signaling. it was also indicated by this increased neural growth to entail antianxiety and antidepressant effects. hu-210, alongside other synthetic cannabinoids like win 55,212-2 and jwh-133, is implicated in preventing the inflammation caused by amyloid beta proteins involved in alzheimer's disease, in addition to preventing cognitive impairment and loss of neuronal markers. this anti-inflammatory action is induced through the activation of cannabinoid receptors, which prevents microglial activation that elicits the inflammation. in addition, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models. hu-210 is a potent analgesic with many of the same effects as natural thc. hu-210 has an oral ld50 of 5,000mg/kg in rats and 14,200mg/kg in rabbits. hu-210 has an ldlo (lowest lethal dose amount) of 143mg/kg in humans. caffeine has an ld50 estimated to be 150–200 milligrams per kilogram. delta-8-thc ld50 has not been confirmed. in a 1973 study monkeys and dogs given 9,000mg/kg of delta-8-thc was nonlethal. chemistry hu-210 is the enantiomer of hu-211 (dexanabinol). the original synthesis of hu-210 is based on an acid-catalyzed condensation of (–)-myrtenol and 1,1-dimethylheptylresorcinol (3,5-dihydroxy-1-(1,1-dimethylheptyl)benzol). hu-210 synthesis legal status hu-210 is not listed in the schedules set out by the united nations' single convention on narcotic drugs from 1961 nor their convention on psychotropic substances from 1971, so the signatory countries to these international drug control treaties are not required by said treaties to control hu-210. new zealand hu-210 is banned in new zealand as of 8 may 2014. united states hu-210 is not listed in the list of scheduled controlled substances in the usa. it is therefore not scheduled at the federal level in the united states, but it is possible that hu-210 could legally be considered an analog of delta-9-thc (which is one of the substances controlled in schedule i as "tetrahydrocannabinols"), and therefore sales or possession could potentially be prosecuted under the federal analogue act. a brief profile of hu-210 written and published by the drug enforcement administration (dea) in 2009 (but subsequently removed from the dea's website several years later) stated that hu-210 is a schedule i controlled substance under the controlled substances act due to being similar to thc. this indicates that the dea might legally consider hu-210 to be an analogue of delta-8-thc for the purposes of applying the federal analog act to those that handle hu-210. an elucidation of the rationale for the dea's claim was not presented, no references were cited, and the claim was eventually removed from the dea's website. a version of the document (updated in 2013), now in pdf form, exists on the dea office of diversion control's website. claimed in this possibly misleading though definitive sounding document, with the same lack of detailed explanation or citation, is: hu-210 is a schedule i controlled substance under the csa. alabama hu-210 is a schedule i controlled substance in alabama. (4)a. a synthetic controlled substance that is any material, mixture, or preparation that contains any quantity of the following chemical compounds, their salts, isomers and salts of isomers, unless specifically excepted, whenever the existence of these salts, isomers and salts of isomers is possible within the specific chemical designation or compound: ... 9. (6ar, 10ar)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzochromen-1-ol, some trade or other names: hu-210. florida hu-210 is a schedule i controlled substance, categorized as a hallucinogen, making it illegal to buy, sell, or possess in the state of florida without a license. (c) unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation that contains any quantity of the following hallucinogenic substances or that contains any of their salts, isomers, including optical, positional, or geometric isomers, homologues, nitrogen-heterocyclic analogs, esters, ethers, and salts of isomers, homologues, nitrogen-heterocyclic analogs, esters, or ethers, if the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation or class description: ... 47. hu-210 chromen-1-ol]. vermont effective january 1, 2016, hu-210 is a regulated drug in vermont designated as a "hallucinogenic drug." “hallucinogenic drug” means those specified in section 7 of this rule including stramonium, mescaline or peyote, lysergic acid diethylamide, and psilocybin, and all synthetic equivalents of chemicals contained in resinous extractives of cannabis sativa, or any salts or derivatives or compounds of any preparations or mixtures thereof, and any other substance having a hallucinogenic effect in the regulations adopted by the board of health under 18 v.s.a.§ 4202. ... • cannabimimetic agents means, collectively, any chemical that is a cannabinoid receptor type 1 (cb1) or cannabinoid receptor type 2 (cb2) agonist, or any salts, isomers, derivatives, or analogs of these chemicals. structural classes include but are not limited to: (a) 2-(3-hydroxycyclohexyl)phenol with substitution at the 5-position of the phenolic ring by alkyl or alkenyl, whether or not substituted on the cyclohexyl ring to any extent. (b) 3-(1-naphthoyl)indole or 3-(1-naphthyl)indole with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent, whether or not substituted on the naphthoyl or naphthyl ring to any extent. (c) 3-(1-naphthoyl)pyrrole with substitution at the nitrogen atom of the pyrrole ring, whether or not further substituted in the pyrrole ring to any extent, whether or not substituted on the naphthoyl ring to any extent. (d) 1-(1-naphthylmethyl)indene with substitution of the 3-position of the indene ring, whether or not further substituted in the indene ring to any extent, whether or not substituted on the naphthyl ring to any extent. (e) 3-phenylacetylindole or 3-benzoylindole with substitution at the nitrogen atom of the indole ring, whether or not further substituted in the indole ring to any extent, whether or not substituted on the phenyl ring to any extent. (f) indole- (2,2,3,3-tetramethylcyclopropyl)methanone, with substitution at the nitrogen atom of the indole ring, whether or not further substituted in the indole ring to any extent, whether or not substituted on the phenyl ring to any extent. (g) n- adamantyl-indole-3-carboxamide, with substitution at the nitrogen atom of the indole ring, whether or not further substituted in the indole ring to any extent, whether or not substituted on the phenyl ring to any extent. (h) (1,3-thiazol-2- ylidine)-2,2,3,3- tetramethylcyclopropane-1-carboxamide, with substitution to any extent at any position of the thiazolylidine ring. ... • hu-210; (6ar,10ar)-9-(hydroxymethyl)-6,6-dimethyl-3- (2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo chromen-1-ol; or chromen-1-ol; or 1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol other hu cannabinoids hu-211 hu-239 hu-243 hu-308 hu-320 hu-331 hu-336 hu-345