laryngo-onycho-cutaneous syndrome laryngo-onycho-cutaneous syndrome laryngo-onycho-cutaneous syndrome (also known as shabbir syndrome) is a rare epithelial disorder inherited in an autosomal recessive fashion. it is characterized by abnormalities in the larynx, nails ("onycho-"), and skin ("cutaneous"). the disorder is only found in punjabi muslims and only a few cases have been reported. laryngoonychocutaneous syndromespecialtydermatology it was characterized by pakistani dermatologist syed ghulam shabbir (1923–2002) in 1986. it may be associated with lama3.