estradiol diacetate estradiol diacetate estradiol diacetate (eda), or estradiol 3,17β-diacetate, is an estrogen and an estrogen ester—specifically, the c3 and c17β diacetate ester of estradiol—which was never marketed. it is related to the estradiol monoesters estradiol acetate (estradiol 3-acetate; femtrace) and estradiol 17β-acetate. affinities and estrogenic potencies of estrogen esters and ethers at the estrogen receptors estrogen other names rba (%)a rep (%)b er erα erβ estradiol e2 100 100 100 estradiol 3-sulfate e2s; e2-3s ? 0.02 0.04 estradiol 3-glucuronide e2-3g ? 0.02 0.09 estradiol 17β-glucuronide e2-17g ? 0.002 0.0002 estradiol benzoate eb; estradiol 3-benzoate 10 1.1 0.52 estradiol 17β-acetate e2-17a 31–45 24 ? estradiol diacetate eda; estradiol 3,17β-diacetate ? 0.79 ? estradiol propionate ep; estradiol 17β-propionate 19–26 2.6 ? estradiol valerate ev; estradiol 17β-valerate 2–11 0.04–21 ? estradiol cypionate ec; estradiol 17β-cypionate ?c 4.0 ? estradiol palmitate estradiol 17β-palmitate 0 ? ? estradiol stearate estradiol 17β-stearate 0 ? ? estrone e1; 17-ketoestradiol 11 5.3–38 14 estrone sulfate e1s; estrone 3-sulfate 2 0.004 0.002 estrone glucuronide e1g; estrone 3-glucuronide ? <0.001 0.0006 ethinylestradiol ee; 17α-ethynylestradiol 100 17–150 129 mestranol ee 3-methyl ether 1 1.3–8.2 0.16 quinestrol ee 3-cyclopentyl ether ? 0.37 ? footnotes: a = relative binding affinities (rbas) were determined via in-vitro displacement of labeled estradiol from estrogen receptors (ers) generally of rodent uterine cytosol. estrogen esters are variably hydrolyzed into estrogens in these systems (shorter ester chain length -> greater rate of hydrolysis) and the er rbas of the esters decrease strongly when hydrolysis is prevented. b = relative estrogenic potencies (reps) were calculated from half-maximal effective concentrations (ec50) that were determined via in-vitro β‐galactosidase (β-gal) and green fluorescent protein (gfp) production assays in yeast expressing human erα and human erβ. both mammalian cells and yeast have the capacity to hydrolyze estrogen esters. c = the affinities of estradiol cypionate for the ers are similar to those of estradiol valerate and estradiol benzoate (figure). sources: see template page. estradiol diacetateclinical dataother nameseda; estradiol 3,17β-diacetate; nsc-106559drug classestrogen; estrogen esteridentifiers iupac name phenanthren-17-yl] acetate cas number3434-88-6 ypubchem cid66431chemspider59804uniix43eu3cq8pchemblchembl3138724comptox dashboard (epa)dtxsid10955895 echa infocard100.020.306 chemical and physical dataformulac22h28o4molar mass356.462 g·mol−13d model (jsmol)interactive image smiles cc(=o)o1cc21(cc32ccc4=c3c=cc(=c4)oc(=o)c)c inchi inchi=1s/c22h28o4/c1-13(23)25-16-5-7-17-15(12-16)4-6-19-18(17)10-11-22(3)20(19)8-9-21(22)26-14(2)24/h5,7,12,18-21h,4,6,8-11h2,1-3h3/t18-,19-,20+,21+,22+/m1/s1key:vqhqlbarmfaksv-aanpdwtmsa-n