dimetotiazine dimetotiazine dimetotiazine (inn) is a phenothiazine drug used for the treatment of migraine. it is a serotonin antagonist and histamine antagonist. dimetotiazineclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationby mouthatc coden02cx05 (who) legal statuslegal status in general: ℞ (prescription only) identifiers iupac name 10-(2-dimethylaminopropyl)-n,n-dimethylphenothiazine-2-sulfonamide cas number7456-24-8 ypubchem cid3089drugbankdb08967 nchemspider2979 nunii1fta475zdbkeggd07854 ycomptox dashboard (epa)dtxsid6023076 echa infocard100.028.390 chemical and physical dataformulac19h25n3o2s2molar mass391.55 g·mol−13d model (jsmol)interactive image smiles cc(cn1c2=cc=cc=c2sc3=c1c=c(c=c3)s(=o)(=o)n(c)c)n(c)c inchi inchi=1s/c19h25n3o2s2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14h,13h2,1-5h3 nkey:vwnwvcjgumzdiu-uhfffaoysa-n n ny (what is this?) (verify) synthesis thieme patent: the sandmeyer reaction on o-(4-dimethylaminosulfonyl-2-nitrophenylthio)aniline (1) gives 4--n,n'-dimethyl-3-nitro-benzenesulfonamide (2). the reduction of the nitro group gives 3-amino-4-((2-bromophenyl)thio)-n,n-dimethylbenzenesulfonamide (3). goldberg reaction gives the chief precursor, 2-dimethylaminosulfonylphenthiazine (4). alkylation of this with 1-chloro-n,n-dimethylpropan-2-amine (5) give dimethothiazine (6).