fomivirsen fomivirsen fomivirsen (brand name vitravene) is an antisense antiviral drug that was used in the treatment of cytomegalovirus retinitis (cmv) in immunocompromised patients, including those with aids. it was administered via intraocular injection. fomivirsenclinical dataahfs/drugs.commicromedex detailed consumer informationpregnancycategory au: b2 routes ofadministrationintravitreal injectionatc codes01ad08 (who) legal statuslegal status withdrawn identifierscas number160369-77-7 ydrugbankdb06759 ychemspidernoneunii3z6w3s36x5keggd02736 ychemblchembl1201688 nchemical and physical dataformulac204h263n63o114p20s20molar mass6682.35 g·mol−1 ny (what is this?) (verify) it was discovered at the nih and was licensed and initially developed by isis pharmaceuticals, which subsequently licensed it to novartis. it was licensed by the fda for cmv in aug 1998, and was the first antisense drug that was approved. novartis withdrew the marketing authorization in the eu in 2002 and in the us in 2006. the drug was withdrawn because while there was a high unmet need for drugs to treat cmv when the drug was initially discovered and developed due to the cmv arising in people with aids, the development of haart dramatically reduced the number of cases of cmv. it is an antisense oligonucleotide -- a synthetic 21 member oligonucleotide with phosphorothioate linkages (which are resistant to degradation by nucleases) and has the sequence: 5'-gcg ttt gct ctt ctt ctt gcg-3' it blocks translation of viral mrna by binding to the complementary sequence of the mrna transcribed from the template segment of a key cmv gene ul123, which encodes the cmv protein ie2. it was the first antisense antiviral approved by the fda.