amastatin amastatin amastatin, also known as 3-amino-2-hydroxy-5-methylhexanoyl-l-valyl-l-valyl-l-aspartic acid, is a naturally occurring, competitive and reversible aminopeptidase inhibitor that was isolated from streptomyces sp. me 98-m3. it specifically inhibits leucyl aminopeptidase, alanyl aminopeptidase (aminopeptidase m/n), bacterial leucyl aminopeptidase (aeromonas proteolytica aminopeptidase), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and, to a lesser extent, glutamyl aminopeptidase (aminopeptidase a), as well as other aminopeptidases. it does not inhibit arginyl aminopeptidase (aminopeptidase b). amastatin has been found to potentiate the central nervous system effects of oxytocin and vasopressin in vivo. it also inhibits the degradation of met-enkephalin, dynorphin a, and other endogenous peptides. amastatinclinical dataatc codenoneidentifiers iupac name (2s)-2-amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]butanedioic acid cas number67655-94-1pubchem cid439518chemspider388612keggc01552comptox dashboard (epa)dtxsid10987015 echa infocard100.131.532 chemical and physical dataformulac21h38n4o8molar mass474.555 g·mol−13d model (jsmol)interactive image smiles cc(c)cc(c(c(=o)nc(c(c)c)c(=o)nc(c(c)c)c(=o)nc(cc(=o)o)c(=o)o)o)n inchi inchi=1s/c21h38n4o8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28h,7-8,22h2,1-6h3,(h,23,29)(h,24,30)(h,25,31)(h,26,27)(h,32,33)/t12-,13+,15+,16+,17+/m1/s1key:qfaadirhlbxjjs-zazjugbxsa-n