angiolipoma angiolipoma angiolipoma is a subcutaneous nodule with vascular structure, having all other features of a typical lipoma. they are commonly painful.: 624 angiolipomalarge mediastinal angiolipomaspecialtyoncology pathology histopathology small vessels in adipose tissue small vessels in adipose tissue small vessels in adipose tissue small vessels in adipose tissue the vessels typically contain hyaline or fibrin (pictured) thrombi diagnosis differential diagnosis kaposi sarcoma angiosarcoma