muscarinic antagonist muscarinic antagonist a muscarinic receptor antagonist (mra) is a type of anticholinergic agent that blocks the activity of the muscarinic acetylcholine receptor. the muscarinic receptor is a protein involved in the transmission of signals through certain parts of the nervous system, and muscarinic receptor antagonists work to prevent this transmission from occurring. notably, muscarinic antagonists reduce the activation of the parasympathetic nervous system. the normal function of the parasympathetic system is often summarised as "rest-and-digest", and includes slowing of the heart, an increased rate of digestion, narrowing of the airways, promotion of urination, and sexual arousal. muscarinic antagonists counter this parasympathetic "rest-and-digest" response, and also work elsewhere in both the central and peripheral nervous systems. muscarinic acetylcholine receptor antagonistdrug classskeletal formula of scopolamine, a nonselective antagonist of the muscarinic receptorsclass identifiersuseallergies, asthma, atrial fibrillation with bradycardia, motion sickness, parkinson's disease, etc.atc codevbiological targetmetabotropic acetylcholinergic receptors.