apolipoprotein l apolipoprotein l apolipoprotein l (apo l) is found in high-density lipoprotein complexes that plays a central role in cholesterol transport. the cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. there are six apo l genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia. apolipoprotein lidentifierssymbolapolpfampf05461interproipr008405available protein structures:pfam structures / ecod pdbrcsb pdb; pdbe; pdbjpdbsumstructure summary human proteins containing this domain apol1; apol2; apol3; apol4; apol5; apol6; apold1;