hbq1 hbq1 hemoglobin subunit theta-1 is a protein that in humans is encoded by the hbq1 gene. hbq1identifiersaliaseshbq1, hbq, hemoglobin subunit theta 1external idsomim: 142240 mgi: 3613460 homologene: 3895 genecards: hbq1 gene location (human)chr.chromosome 16 (human)band16p13.3start180,459 bpend181,179 bpgene location (mouse)chr.chromosome 11 (mouse)band11|11 a4start32,236,965 bpend32,237,784 bprna expression patternbgeehumanmouse (ortholog)top expressed inbloodmonocytecancellous bonenucleus accumbensbone marrowamygdalabrodmann area 9caudate nucleusputamenhypothalamustop expressed inbone marrowyolk sacspleenlobe of liverplacentasuperior frontal gyrusneural tubemesencephaloncerebellar cortexheartmore reference expression databiogpsmore reference expression datagene ontologymolecular function iron ion binding oxygen binding protein binding heme binding metal ion binding oxygen carrier activity peroxidase activity haptoglobin binding organic acid binding cellular component hemoglobin complex haptoglobin-hemoglobin complex biological process oxygen transport hydrogen peroxide catabolic process protein heterooligomerization cellular oxidant detoxification sources:amigo / quickgoorthologsspecieshumanmouseentrez3049544763ensemblensg00000086506ensmusg00000073063uniprotp09105q3u0a6refseq (mrna)nm_005331nm_001033981refseq (protein)np_005322np_001029153location (ucsc)chr 16: 0.18 – 0.18 mbchr 11: 32.24 – 32.24 mbpubmed searchwikidataview/edit humanview/edit mouse theta-globin mrna is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. the theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. the order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.