iloperidone iloperidone iloperidone, commonly known as fanapt and previously known as zomaril, is an atypical antipsychotic for the treatment of schizophrenia. iloperidoneclinical datatrade namesfanapt, zomarilahfs/drugs.commonographmedlineplusa609026license data us fda: iloperidone routes ofadministrationoral, injectiondrug classatypical antipsychoticatc coden05ax14 (who) legal statuslegal status us: ℞-only pharmacokinetic databioavailability96% (oral; tmax = 2–4 hours)protein binding~97%metabolismhepatic (cyp2d6-mediated hydroxylation and cyp3a4-mediated o-demethylation)elimination half-life18–33 hoursexcretionurine (45.1–58.2%) and feces (19.9–22.1%)identifiers iupac name 1-propoxy]-3-methoxyphenyl]ethanone cas number133454-47-4 ypubchem cid71360iuphar/bps87chemspider64459 yuniivpo7kj050nkeggd02666 ychebichebi:65173 nchemblchembl14376 ycomptox dashboard (epa)dtxsid6049060 echa infocard100.106.441 chemical and physical dataformulac24h27fn2o4molar mass426.488 g·mol−13d model (jsmol)interactive image smiles o=c(c4ccc(occcn3ccc(c2noc1cc(f)ccc12)cc3)c(oc)c4)c inchi inchi=1s/c24h27fn2o4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17h,3,8-13h2,1-2h3 ykey:xmxhebafvsfqex-uhfffaoysa-n y ny (what is this?) (verify) medical uses iloperidone is indicated for the treatment of schizophrenia. in a 2013 study in a comparison of 15 antipsychotic drugs in effectivity in treating schizophrenic symptoms, iloperidone demonstrated mild effectiveness. as effective as lurasidone, and 13 to 15% less effective than ziprasidone, chlorpromazine, and asenapine. it generally appears to work better than placebo. side effects examination of the safety and tolerability of iloperidone have shown that at a 5 mg/day dose in healthy male volunteers, the drug was fairly well tolerated, although hypotension, dizziness, and somnolence were very common side effects ranging from mild to moderate in severity. a second study showed that co administration of food decreased the severity of these effects. this study also indicated that repeat administration of iloperidone could decrease the effects of hypotension. the approved dose is 12–24 mg not 5 mg. however, claims of better tolerance have been reported. discontinuation the british national formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. other symptoms may include restlessness, increased sweating, and trouble sleeping. less commonly there may be a feeling of the world spinning, numbness, or muscle pains. symptoms generally resolve after a short period of time. there is tentative evidence that discontinuation of antipsychotics can result in psychosis. it may also result in reoccurrence of the condition that is being treated. rarely tardive dyskinesia can occur when the medication is stopped. pharmacology