18,19-dehydrobuprenorphine 18,19-dehydrobuprenorphine 18,19-dehydrobuprenorphine (hs-599) is a didehydro derivative of buprenorphine. it has about twice the potency of buprenorphine. it has produced a long-lasting antinociceptive response in animal tests. 18,19-dehydrobuprenorphine names iupac name 17-cyclopropylmethyl-4,5α-epoxy-6α,14α etheno-7α-(1-hydroxy-1,2,2-trimethylpropyl)-6β-methoxymorphinan-3-ol other names hs 599 identifiers cas number 155203-05-7 y 3d model (jsmol) interactive image pubchem cid 101720618 inchi inchi=1s/c29h39no4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-11,17,20-21,24,31-32h,6-7,12-16h2,1-5h3/t20-,21-,24-,26+,27+,28+,29?/m1/s1key: xxeuufwmpbshce-nfcpxprcsa-n smiles c(1c23c=cc1(425ccn(3cc6=c5c(=c(c=c6)o)o4)cc7cc7)oc)(c(c)(c)c)o properties chemical formula c29h39no4 molar mass 465.634 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references 18,19-dehydrobuprenorphine never induced conditioned place-preference in test animals, unlike buprenorphine and morphine. 18,19-dehydrobuprenorphine has about three times higher affinity for the μ-opioid receptor but lower affinity for δ- and κ-opioid receptors when compared with buprenorphine.