1-methylnicotinamide 1-methylnicotinamide 1-methylnicotinamide (trigonellamide) is a prototypic organic cation. 1-methylnicotinamide is the methylated amide of nicotinamide (niacinamide, vitamin b3). 1-methylnicotinamide names preferred iupac name 3-carbamoyl-1-methylpyridin-1-ium other names trigonellamide; n1-methylnicotinamide; nmn identifiers cas number 3106-60-3 3d model (jsmol) interactive image chebi chebi:16797 chembl chembl71733 chemspider 444 pubchem cid 457 unii um47085bxc comptox dashboard (epa) dtxsid10185019 smiles c1=cc=cc(=c1)c(=o)n properties chemical formula c7h9n2o+ molar mass 137.161 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references 1-methylnicotinamide is an endogenic substance that is produced in the liver when nicotinamide is metabolized. it is a typical substance secreted in the kidney. occurrence the highest natural concentration of 1-methylnicotinamide found so far is in the alga undaria pinnatifida. 1-methylnicotinamide is also present in the judas' ear fungus and in green tea. extraction and production 1-methylnicotinamide can be produced in the liver by nicotinamide n-methyltransferase. the reaction takes place during the metabolism of nad (nicotinamide adenine dinucleotide). nnmt (nicotinamide n-methyltransferase) is an enzyme that in humans is encoded by the nnmt gene. nnmt catalyzes the methylation of nicotinamide and similar compounds using the methyl donor s-adenosyl methionine (sam-e) to produce s-adenosyl-l-homocysteine (sah) and 1-methylnicotinamide. nnmt is highly expressed in the human liver. use for a long time, 1-methylnicotinamide was considered a biologically inactive metabolite of nicotinamide. however, various studies show antithrombotic, anti-inflammatory, gastroprotective and vasoprotective properties. 1-methylnicotinamide is an endogenous activator of prostacyclin synthesis and can therefore regulate thrombolytic and inflammatory processes in the cardiovascular system. it inhibits platelet-dependent thrombosis through a mechanism involving cyclooxygenase-2 and prostacyclin and increases nitric oxide bioavailability in the endothelium. animal experiments with diabetic rats have shown that 1-methylnicotinamide has a positive effect on degenerative changes in the brain and cognitive performance can be thus longer maintained. experiments with the nematode caenorhabditis elegans showed that the addition of 1-methylnicotinamide can extend their lifespan. this may possibly be attributed to increased free radical binding and the resulting reduced oxidative stress. 1-methylnicotinamide is used in cosmetic products such as hair- and skincare products and as a dietary supplement.