trifluperidol trifluperidol trifluperidol is a typical antipsychotic of the butyrophenone chemical class. it has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. it is used in the treatment of psychoses including mania and schizophrenia. it was discovered at janssen pharmaceutica in 1959. trifluperidolclinical datatrade namestriperidolahfs/drugs.cominternational drug namesroutes ofadministrationoralatc coden05ad02 (who) identifiers iupac name 1-(4-fluorophenyl)-4-piperidin-1-yl]butan-1-one cas number749-13-3 ypubchem cid5567drugbankdb13552 ychemspider5366 yuniir8869q7r8ichemblchembl15023 ycomptox dashboard (epa)dtxsid4023703 chemical and physical dataformulac22h23f4no2molar mass409.425 g·mol−13d model (jsmol)interactive image smiles fc(f)(f)c1cccc(c1)c3(o)ccn(cccc(=o)c2ccc(f)cc2)cc3 inchi inchi=1s/c22h23f4no2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29h,2,5,10-14h2 ykey:gpmxuuphfnmndh-uhfffaoysa-n y synthesis thieme patent (claim 9): precursor: sila analogue: the grignard reaction between 1-benzyl-4-piperidone (1) and 3-bromobenzotrifluoride (2) gives 1-benzyl-4-(3-(trifluoromethyl)phenyl)piperidin-4-ol, cid:12718203 (3). catalytic hydrogenation removes the benzyl protecting group to give 4--4-piperidinol (4). alkylation with 4-chloro-4'-fluorobutyrophenone (5) introduces the sidechain and hence completed the synthesis of trifluperidol (6).