roy (nicolas cage) with ocd who opens and closes doors three times while counting aloud before he can walk through them. in the television series monk (2002–2009), the titular character adrian monk fears both human contact and dirt. in the novel turtles all the way down (2017) by john green, teenage main character aza holmes struggles with ocd that manifests as a fear of the human microbiome. throughout the story, aza repeatedly opens an unhealed callus on her finger to drain out what she believes are pathogens. the novel is based on green's own experiences with ocd. he explained that turtles all the way down is intended to show how "most people with chronic mental illnesses also live long, fulfilling lives". the british tv series pure (2019) stars charly clive as a 24-year-old marnie who is plagued by disturbing sexual thoughts, as a kind of primarily obsessional obsessive compulsive disorder. research the naturally occurring sugar inositol has been suggested as a treatment for ocd. μ-opioids, such as hydrocodone and tramadol, may improve ocd symptoms. administration of opiate treatment may be contraindicated in individuals concurrently taking cyp2d6 inhibitors such as fluoxetine and paroxetine. much current research is devoted to the therapeutic potential of the agents that affect the release of the neurotransmitter glutamate or the binding to its receptors. these include riluzole, memantine, gabapentin, n-acetylcysteine, topiramate and lamotrigine. other animals