connective tissue nevus connective tissue nevus a connective tissue nevus is a skin lesion which may be present at birth or appear within the first few years of life. it is elevated, soft to firm in consistency, varying in size from 0.5 to several centimeters in diameter, and may manifest as grouped, linear, or irregularly-distributed lesions.: 993 connective tissue nevusother namescollagenoma, elastoma, and shagreen patchstoriform collagenoma, h&e stainspecialtydermatology