tumors is surgical removal. in almost all cases this removal is curative, i.e. tumor recurrences are uncommon, even in cases where the tumor is only partially removed. furthermore, tumor recurrences are typically cured by simple re-excisions. nf cases have also been successfully treated with corticosteroid drugs (e.g. triamcinolone) injected directly into the tumor; this treatment has been most often used for patients with recurrent tumors. some studies, however, have suggested reevaluating the diagnosis in recurrent nf tumors to ensure the diagnosis is correct. surgical and corticosteroid interventions may need to be performed promptly in order to avoid expansion of a cranial tumor into the skull's interior or an intravascular fasciitis tumor from compromising blood flood flow. prognosis two cases of nf in which their tumor cells expressed a usp6-ppp6r3 fusion gene had highly aggressive, locally invasive, repeatedly recurrent (after surgical removal), and progressively enlarging tumors over 2 and ten years. one case developed multiple metastases (i.e. spread of a tumor to different parts of the body) that along with the primary tumor site were partially controlled with radiation therapy. the other case was treated by wide surgical resection of the tumor; this case did not have metastatic disease and one year after the wide resection had no recurrences.