77-lh-28-1 77-lh-28-1 77-lh-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (m1) discovered in 2008. it is an allosteric agonist, exhibiting over 100-fold specificity for m1 over other muscarinic receptor subtypes. 77-lh-28-1 penetrates the brain by crossing the blood–brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects. 77-lh-28-1identifiers iupac name 1--3,4-dihydroquinolin-2-one cas number560085-11-2pubchem cid10236758iuphar/bps3271chemspider8412246comptox dashboard (epa)dtxsid90437063 chemical and physical dataformulac21h32n2omolar mass328.500 g·mol−13d model (jsmol)interactive image smiles o=c2n(c1ccccc1cc2)cccn3ccc(cc3)cccc inchi inchi=1s/c21h32n2o/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18h,2-3,6-7,10-17h2,1h3key:phmgzaicaoyeaf-uhfffaoysa-n