neocortex neocortex the neocortex, also called the neopallium, isocortex, or the six-layered cortex, is a set of layers of the mammalian cerebral cortex involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language. the neocortex is further subdivided into the true isocortex and the proisocortex. neocortexa representative column of neocortex. cell body layers are labeled on the left, and fiber layers are labeled on the right.identifiersmeshd019579neuronames757neurolex idbirnlex_2547ta98a14.1.09.304 a14.1.09.307ta25532fma62429anatomical terms of neuroanatomy in the human brain, the neocortex is the largest part of the cerebral cortex (the outer layer of the cerebrum). the neocortex makes up the largest part of the cerebral cortex, with the allocortex making up the rest. the neocortex is made up of six layers, labelled from the outermost inwards, i to vi. etymology the term is from cortex, latin, "bark" or "rind", combined with neo-, greek, "new". neopallium is a similar hybrid, from latin pallium, "cloak". isocortex and allocortex are hybrids with greek isos, "same", and allos, "other". anatomy the neocortex is the most developed in its organisation and number of layers, of the cerebral tissues. the neocortex consists of the grey matter, or neuronal cell bodies and unmyelinated fibers, surrounding the deeper white matter (myelinated axons) in the cerebrum. this is a very thin layer though, about 2–4 mm thick. there are two types of cortex in the neocortex, the proisocortex and the true isocortex. the pro-isocortex is a transitional area between the true isocortex and the periallocortex (part of the allocortex). it is found in the cingulate cortex (part of the limbic system), in brodmann's areas 24, 25, 30 and 32, the insula and the parahippocampal gyrus. of all the mammals studied to date (including humans), a species of oceanic dolphin known as the long-finned pilot whale has been found to have the most neocortical neurons. geometry the neocortex is smooth in rodents and other small mammals, whereas in elephants, dolphins and primates and other larger mammals it has deep grooves (sulci) and ridges (gyri). these folds allow the surface area of the neocortex to be greatly increased. all human brains have the same overall pattern of main gyri and sulci, although they differ in detail from one person to another. the mechanism by which the gyri form during embryogenesis is not entirely clear, and there are several competing hypotheses that explain gyrification, such as axonal tension, cortical buckling or differences in cellular proliferation rates in different areas of the cortex. layers the neocortex contains both excitatory (~80%) and inhibitory (~20%) neurons, named for their effect on other neurons. the human neocortex consists of hundreds of different types of cells. the structure of the neocortex is relatively uniform (hence the alternative names "iso-" and "homotypic" cortex), consisting of six horizontal layers segregated principally by cell type and neuronal connections. however, there are many exceptions to this uniformity; for example, layer iv is small or missing in the primary motor cortex. there is some canonical circuitry within the cortex; for example, pyramidal neurons in the upper layers ii and iii project their axons to other areas of neocortex, while those in the deeper layers v and vi often project out of the cortex, e.g. to the thalamus, brainstem, and spinal cord. neurons in layer iv receive the majority of the synaptic connections from outside the cortex (mostly from thalamus), and themselves make short-range, local connections to other cortical layers. thus, layer iv is the main recipient of incoming sensory information and distributes it to the other layers for further processing. cortical columns the neocortex is often described as being arranged in vertical structures called cortical columns, patches of neocortex with a diameter of roughly 0.5 mm (and a depth of 2 mm, i.e., spanning all six layers). these columns are often thought of as the basic repeating functional units of the neocortex, but their many definitions, in terms of anatomy, size, or function, are generally not consistent with each other, leading to a lack of consensus regarding their structure or function or even whether it makes sense to try to understand neocortex in terms of columns. function the neocortex is derived embryonically from the dorsal telencephalon, which is the rostral part of the forebrain. the neocortex is divided, into regions demarcated by the cranial sutures in the skull above, into frontal, parietal, occipital, and temporal lobes, which perform different functions. for example, the occipital lobe contains the primary visual cortex, and the temporal lobe contains the primary auditory cortex. further subdivisions or areas of neocortex are responsible for more specific cognitive processes. in humans, the frontal lobe contains areas devoted to abilities that are enhanced in or unique to our species, such as complex language processing localized to the ventrolateral prefrontal cortex (broca's area). in humans and other primates, social and emotional processing is localized to the orbitofrontal cortex. the neocortex has also been shown to play an influential role in sleep, memory and learning processes. semantic memories appear to be stored in the neocortex, specifically the anterolateral temporal lobe of the neocortex. it is also involved in instrumental conditioning; responsible for transmitting sensory information and information about plans for movement to the basal ganglia. the firing rate of neurons in the neocortex also has an effect on slow-wave sleep. when the neurons are at rest and are hyperpolarizing, a period of inhibition occurs during a slow oscillation, called the down state. when the neurons of the neocortex are in the excitatory depolarizing phase and are firing briefly at a high rate, a period of excitation occurs during a slow oscillation, called the up state. clinical significance lesions that develop in neurodegenerative disorders, such as alzheimer's disease, interrupt the transfer of information from the sensory neocortex to the prefrontal neocortex. this disruption of sensory information contributes to the progressive symptoms seen in neurodegenerative disorders such as changes in personality, decline in cognitive abilities, and dementia. damage to the neocortex of the anterolateral temporal lobe results in semantic dementia, which is the loss of memory of factual information (semantic memories). these symptoms can also be replicated by transcranial magnetic stimulation of this area. if damage is sustained to this area, patients do not develop anterograde amnesia and are able to recall episodic information. evolution