valorphin valorphin valorphin, also known as vv-hemorphin-5, is a naturally occurring, endogenous opioid heptapeptide of the hemorphin family with the amino acid sequence h-val-val-tyr-pro-trp-thr-gln-oh (vvypwtq). it is produced in the body via proteolyic cleavage of residues 33-39 of the β-chain of hemoglobin. valorphin binds preferentially to the μ-opioid receptor and produces effects such as analgesia and self-administration in animals. it also possesses cytotoxic and antiproliferative properties against tumor cells, the mediation of which, because they are reversed by naloxone, appears to be dependent on the opioid receptors. valorphin names iupac name l-valyl-l-valyl-l-tyrosyl-l-prolyl-l-tryptophyl-l-threonyl-l-glutamine identifiers cas number 144313-54-2 n 3d model (jsmol) interactive image chemspider 27470960 pubchem cid 90470048 inchi inchi=1s/c44h60n8o12/c1-22(2)35(45)40(59)50-36(23(3)4)41(60)49-32(19-25-12-14-27(54)15-13-25)43(62)52-18-8-11-33(52)39(58)48-31(20-26-21-46-29-10-7-6-9-28(26)29)38(57)51-37(24(5)53)42(61)47-30(44(63)64)16-17-34(55)56/h6-7,9-10,12-15,21-24,30-33,35-37,46,53-54h,8,11,16-20,45h2,1-5h3,(h,47,61)(h,48,58)(h,49,60)(h,50,59)(h,51,57)(h,55,56)(h,63,64)/t24-,30+,31+,32+,33+,35+,36+,37+/m1/s1key: cnywvxyfckfxll-nmuvprmfsa-n smiles c((c(=o)n(ccc(=o)n)c(=o)o)nc(=o)(cc1cc2c1cccc2)nc(=o)3cccn3c(=o)(cc4ccc(cc4)o)nc(=o)(c(c)c)nc(=o)(c(c)c)n)o properties chemical formula c44h61n9o11 molar mass 892.024 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references