zadik–barak–levin syndrome zadik–barak–levin syndrome zadik–barak–levin syndrome (zbls) is a congenital disorder in humans. presenting conditions include primary hypothyroidism, cleft palate, hypodontia, and ectodermal dysplasia. it is the result of an embryonic defect in the mesodermal-ectodermal midline development. zadik–barak–levin syndromeother namesdermoid cysts, hypothyroidism, cleft palate and hypodontia signs and symptoms anodontia/oligodontia—no teeth or fewer teeth than normal cleft palate depressed nasal bridge dry skin ectopic/agenesis/hypoplastic thyroid epibulbar dermoid frontal bossing hypertelorism hypothyroidy lordosis macroglossia microcephaly micrognatia/retrognatia—small or recessed jaw(s) polyhydramnios short stature/dwarfism sparse/absent scalp hair(generalized) squint/paresis of ocular muscles umbilical hernia