amely amely amelogenin, y isoform is a protein that in humans is encoded by the amely gene. amely is located on the y chromosome and encodes a form of amelogenin. amelogenin is an extracellular matrix protein involved in biomineralization during tooth enamel development. amelyidentifiersaliasesamely, amgl, amgy, amelogenin, y-linked, amelogenin y-linkedexternal idsomim: 410000 mgi: 88005 homologene: 47996 genecards: amely gene location (human)chr.y chromosome (human)bandyp11.2start6,865,918 bpend6,911,752 bpgene location (mouse)chr.x chromosome (mouse)bandx f5|x 78.95 cmstart167,959,110 bpend167,970,196 bprna expression patternbgeehumanmouse (ortholog)top expressed insural nerveplacentathyroid glandleft lobe of thyroid glandhepatobiliary systempancreasbody of pancreasright lobe of thyroid glandislet of langerhansgallbladdertop expressed inmolarnucleus pulposussexually immature organismtemporal muscleascending aortaaortic valveolfactory epitheliumdermisuterusthymusmore reference expression databiogpsn/agene ontologymolecular function structural constituent of tooth enamel cellular component extracellular matrix extracellular region collagen-containing extracellular matrix biological process multicellular organism development biomineral tissue development tooth mineralization sources:amigo / quickgoorthologsspecieshumanmouseentrez26611704ensemblensg00000099721ensmusg00000031354uniprotq99218p63277refseq (mrna)nm_001143nm_001364814nm_001081978nm_009666nm_001290371refseq (protein)np_001134np_001351743np_001075447np_001277300np_033796location (ucsc)chr y: 6.87 – 6.91 mbchr x: 167.96 – 167.97 mbpubmed searchwikidataview/edit humanview/edit mouse clinical significance mutations in the related amelx gene on the x chromosome cause x-linked amelogenesis imperfecta.