cryonics cryonics cryonics (from greek: κρύος kryos meaning 'cold') is the low-temperature freezing (usually at −196 °c or −320.8 °f or 77.1 k) and storage of human remains, with the speculative hope that resurrection may be possible in the future. cryonics is regarded with skepticism within the mainstream scientific community. it is generally viewed as a pseudoscience, and its practice has been characterized as quackery. technicians prepare a body for cryopreservation in 1985. cryonics procedures can begin only after the "patients" are clinically and legally dead. cryonics procedures may begin within minutes of death, and use cryoprotectants to try to prevent ice formation during cryopreservation. it is, however, not possible for a corpse to be reanimated after undergoing vitrification, as this causes damage to the brain including its neural circuits. the first corpse to be frozen was that of james bedford in 1967. as of 2014, about 250 bodies had been cryopreserved in the united states, and 1,500 people had made arrangements for cryopreservation of their corpses. critics argue that economic reality means it is highly improbable that any cryonics corporation could continue in business long enough to take advantage of the claimed long-term benefits offered. early attempts of cryonic preservations were performed in the 1960s and early 1970s which ended in failure with all but one of the companies going out of business, and their stored corpses thawed and disposed of. conceptual basis cryonicists argue that as long as brain structure remains intact, there is no fundamental barrier, given our current understanding of physical law, to recovering its information content. cryonics proponents go further than the mainstream consensus in saying that the brain does not have to be continuously active to survive or retain memory. cryonics controversially states that a human survives even within an inactive brain that has been badly damaged, provided that original encoding of memory and personality can, in theory, be adequately inferred and reconstituted from what structure remains. cryonics uses temperatures below −130 °c, called cryopreservation, in an attempt to preserve enough brain information to permit the future revival of the cryopreserved person. cryopreservation may be accomplished by freezing, freezing with cryoprotectant to reduce ice damage, or by vitrification to avoid ice damage. even using the best methods, cryopreservation of whole bodies or brains is very damaging and irreversible with current technology. cryonics advocates hold that in the future the use of some kind of presently-nonexistent nanotechnology may be able to help bring the dead back to life and treat the diseases which killed them. mind uploading has also been proposed. cryonics in practice cryonics can be expensive. as of 2018, the cost of preparing and storing corpses using cryonics ranged from us$28,000 to $200,000. when used at high concentrations, cryoprotectants can stop ice formation completely. cooling and solidification without crystal formation is called vitrification. the first cryoprotectant solutions able to vitrify at very slow cooling rates while still being compatible with whole organ survival were developed in the late 1990s by cryobiologists gregory fahy and brian wowk for the purpose of banking transplantable organs. this has allowed animal brains to be vitrified, warmed back up, and examined for ice damage using light and electron microscopy. no ice crystal damage was found; cellular damage was due to dehydration and toxicity of the cryoprotectant solutions. costs can include payment for medical personnel to be on call for death, vitrification, transportation in dry ice to a preservation facility, and payment into a trust fund intended to cover indefinite storage in liquid nitrogen and future revival costs. as of 2011, u.s. cryopreservation costs can range from $28,000 to $200,000, and are often financed via life insurance. kriorus, which stores bodies communally in large dewars, charges $12,000 to $36,000 for the procedure. some customers opt to have only their brain cryopreserved ("neuropreservation"), rather than their whole body. as of 2014, about 250 corpses have been cryogenically preserved in the u.s., and around 1,500 people have signed up to have their remains preserved. as of 2016, four facilities exist in the world to retain cryopreserved bodies: three in the u.s. and one in russia. considering the lifecycle of corporations, it is extremely unlikely that any cryonics company could continue to exist for sufficient time to take advantage even of the supposed benefits offered: historically, even the most robust corporations have only a one-in-a-thousand chance of surviving even one hundred years. many cryonics companies have failed; as of 2018, all but one of the pre-1973 batch had gone out of business, and their stored corpses have been defrosted and disposed of. obstacles to success preservation damage cryopreservation has long been used by medical laboratories to maintain animal cells, human embryos, and even some organized tissues, for periods as long as three decades. recovering large animals and organs from a frozen state is however not considered possible at the current level of scientific knowledge large vitrified organs tend to develop fractures during cooling, a problem worsened by the large tissue masses and very low temperatures of cryonics. without cryoprotectants, cell shrinkage and high salt concentrations during freezing usually prevent frozen cells from functioning again after thawing. ice crystals can also disrupt connections between cells that are necessary for organs to function. in 2016, robert l. mcintyre and gregory fahy at the cryobiology research company 21st century medicine, inc. won the small animal brain preservation prize of the brain preservation foundation by demonstrating to the satisfaction of neuroscientist judges that a particular implementation of fixation and vitrification called aldehyde-stabilized cryopreservation could preserve a rabbit brain in "near perfect" condition at −135 °c, with the cell membranes, synapses, and intracellular structures intact in electron micrographs. brain preservation foundation president, ken hayworth, said, "this result directly answers a main skeptical and scientific criticism against cryonics—that it does not provably preserve the delicate synaptic circuitry of the brain." however, the price paid for perfect preservation, as seen by microscopy, was tying up all protein molecules with chemical crosslinks, eliminating biological viability. some cryonics organizations use vitrification without a chemical fixation step, sacrificing some structural preservation quality for less damage at the molecular level. some scientists, like joão pedro magalhães, have questioned whether using a deadly chemical for fixation eliminates the possibility of biological revival, making chemical fixation unsuitable for cryonics. outside of cryonics firms and cryonics-linked interest groups, many scientists show strong skepticism toward cryonics methods. cryobiologist dayong gao states that "we simply don't know if (subjects have) been damaged to the point where they've 'died' during vitrification because the subjects are now inside liquid nitrogen canisters." biochemist ken storey argues (based on experience with organ transplants), that "even if you only wanted to preserve the brain, it has dozens of different areas, which would need to be cryopreserved using different protocols." revival revival would require repairing damage from lack of oxygen, cryoprotectant toxicity, thermal stress (fracturing) and freezing in tissues that do not successfully vitrify, finally followed by reversing the cause of death. in many cases, extensive tissue regeneration would be necessary. this revival technology remains speculative and does not currently exist. legal issues historically, a person had little control regarding how their body was treated after death as religion held jurisdiction over the ultimate fate of their body. however, secular courts began to exercise jurisdiction over the body and use discretion in carrying out of the wishes of the deceased person. most countries legally treat preserved individuals as deceased persons because of laws that forbid vitrifying someone who is medically alive. in france, cryonics is not considered a legal mode of body disposal; only burial, cremation, and formal donation to science are allowed. however, bodies may legally be shipped to other countries for cryonic freezing. as of 2015, the canadian province of british columbia prohibits the sale of arrangements for body preservation based on cryonics. in russia, cryonics falls outside both the medical industry and the funeral services industry, making it easier in russia than in the u.s. to get hospitals and morgues to release cryonics candidates. in london in 2016, the english high court ruled in favor of a mother's right to seek cryopreservation of her terminally ill 14-year-old daughter, as the girl wanted, contrary to the father's wishes. the decision was made on the basis that the case represented a conventional dispute over the disposal of the girl's body, although the judge urged ministers to seek "proper regulation" for the future of cryonic preservation following concerns raised by the hospital about the competence and professionalism of the team that conducted the preservation procedures. in alcor life extension foundation v. richardson, the iowa court of appeals ordered for the disinterment of richardson, who was buried against his wishes, for cryopreservation. a detailed legal examination by jochen taupitz concludes that cryonic storage is legal in germany for an indefinite period of time. ethics in 2009, writing in bioethics, david shaw examines the ethical status of cryonics. the arguments against it include changing the concept of death, the expense of preservation and revival, lack of scientific advancement to permit revival, temptation to use premature euthanasia, and failure due to catastrophe. arguments in favor of cryonics include the potential benefit to society, the prospect of immortality, and the benefits associated with avoiding death. shaw explores the expense and the potential payoff, and applies an adapted version of pascal's wager to the question. in 2016, charles tandy wrote in favor of cryonics, arguing that honoring someone's last wishes is seen as a benevolent duty in american and many other cultures. history cryopreservation was applied to human cells beginning in 1954 with frozen sperm, which was thawed and used to inseminate three women. the freezing of humans was first scientifically proposed by michigan professor robert ettinger when he wrote the prospect of immortality (1962). in april 1966, the first human body was frozen—though it had been embalmed for two months—by being placed in liquid nitrogen and stored at just above freezing. the middle-aged woman from los angeles, whose name is unknown, was soon thawed out and buried by relatives. the first body to be cryopreserved and then frozen with the hope of future revival was that of james bedford, claimed by alcor's mike darwin to have occurred within around two hours of his death from cardiorespiratory arrest (secondary to metastasized kidney cancer) on january 12, 1967. bedford's corpse is the only one frozen before 1974 still preserved today. in 1976, ettinger founded the cryonics institute; his corpse was cryopreserved in 2011. robert nelson, "a former tv repairman with no scientific background" who led the cryonics society of california, was sued in 1981 for allowing nine bodies to thaw and decompose in the 1970s; in his defense, he claimed that the cryonics society had run out of money. this led to the lowered reputation of cryonics in the u.s. in 2018, a y-combinator startup called nectome was recognized for developing a method of preserving brains with chemicals rather than by freezing. the method is fatal, performed as euthanasia under general anesthesia, but the hope is that future technology would allow the brain to be physically scanned into a computer simulation, neuron by neuron. demographics according to the new york times, cryonicists are predominantly non-religious white males, outnumbering women by about three to one. according to the guardian, as of 2008, while most cryonicists used to be young, male, and "geeky", recent demographics have shifted slightly towards whole families. in 2015, du hong, a 61-year-old female writer of children's literature, became the first known chinese national to have her head cryopreserved. reception cryonics is generally regarded as a fringe pseudoscience. the society for cryobiology rejected members who practiced cryonics, and issued a public statement saying that cryonics is "not science", and that it is a "personal choice" how people want to have their dead bodies disposed of. russian company kriorus is the first non-us vendor of cryonics services. yevgeny alexandrov, chair of the russian academy of sciences commission against pseudoscience, said there was "no scientific basis" for cryonics, and that the company's offering was based on "unfounded speculation". scientists have expressed skepticism about cryonics in media sources, and the norwegian philosopher ole martin moen has written that the topic receives a "minuscule" amount of attention from academia. while some neuroscientists contend that all the subtleties of a human