ubenimex ubenimex ubenimex (inn), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. it is an inhibitor of arginyl aminopeptidase (aminopeptidase b), leukotriene a4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase m/n), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene d4 hydrolase). it is being studied for use in the treatment of acute myelocytic leukemia and lymphedema. it is derived from streptomyces olivoreticuli. ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds. crystal structure of ubenimex in the binding pocket of leukotriene a4 hydrolase. rendered from pdb 1hs6. ubenimex names iupac name n--l-leucine systematic iupac name (2s)-2--4-methylpentanoic acid other names bestatin; n--l-leucine identifiers cas number 58970-76-6 y65391-42-6 (hcl) 3d model (jsmol) interactive image chembl chembl29292 y chemspider 65145 drugbank db03424 echa infocard 100.055.917 ec number 261-529-2 kegg d00087 pubchem cid 72172 unii i0j33n5627 y comptox dashboard (epa) dtxsid4048430 inchi inchi=1s/c16h24n2o4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19h,8-9,17h2,1-2h3,(h,18,20)(h,21,22)/t12-,13+,14+/m1/s1key: vgggpcqerpfhob-rdbsujkosa-n smiles cc(c)c(c(=o)o)nc(=o)((cc1=cc=cc=c1)n)o properties chemical formula c16h24n2o4 molar mass 308.378 g·mol−1 melting point 245 °c (473 °f; 518 k) (decomposes) hazards ghs labelling: pictograms signal word warning hazard statements h315, h319, h335 precautionary statements p261, p264, p271, p280, p302+p352, p304+p340, p305+p351+p338, p312, p321, p332+p313, p337+p313, p362, p403+p233, p405 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). y verify (what is yn ?) infobox references