sertoli cell nodule sertoli cell nodule a sertoli cell nodule is a benign proliferation of sertoli cells that arises in association with cryptorchidism (undescended testis). they are not composed of a clonal cell population, i.e. neoplastic; thus, technically, they should not be called an adenoma. sertoli cell noduleother namespick's adenoma, testicular tubular adenoma, tubular adenoma of the testismicrograph of a sertoli cell nodule. h&e stain.specialtyurology pathology sertoli cell nodules are unencapsulated nodules that consist of: cells arranged in well-formed tubules (that vaguely resemble immature sertoli cells), with bland hyperchromatic oval/round nuclei that are stratified, and may contain eosinophilic (hyaline) blob in lumen (centre). micrograph of a sertoli cell nodule. h&e stain. micrograph of a sertoli cell nodule. h&e stain.