e-6837 e-6837 e-6837 is an orally active, 5-ht6 agonist developed in an attempt to create an anti-obesity medication. in cell lines expressing rat 5-ht6 receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist on human 5-ht6 receptors (which are constitutively active). oral administration of e-6837 reduced food intake, but only transiently. in rats, twice daily administration of e-6837 over the course of 4 weeks resulted in a 15.7% reduction in body weight, compared to 11% reduction for sibutramine. this weight loss remained significant for e-6837 after a 43-day withdrawal period, whereas the weight difference was non-significant for sibutramine (i.e., sibutramine had a rebound effect while e-6837 did not), and this weight loss was found to be due to a loss of fat mass. the reduction in fat mass in e-6837 treated animals was associated with a 50% decrease in plasma leptin levels, and also reduced glucose and insulin levels in plasma after a glucose tolerance test. this indicates that weight loss from e-6837 is associated with improved insulin sensitivity, and thus, better glycemic control. e-6837 names preferred iupac name 5-chloro-n-naphthalene-2-sulfonamide other names e 6837 identifiers cas number 528859-61-2 y 3d model (jsmol) interactive image chembl chembl175835 chemspider 5294027 mesh c500059 pubchem cid 6918836 unii 4axx8p95bu y inchi inchi=1s/c22h22cln3o2s/c1-26(2)11-10-16-14-24-22-9-6-17(13-20(16)22)25-29(27,28)18-7-8-19-15(12-18)4-3-5-21(19)23/h3-9,12-14,24-25h,10-11h2,1-2h3key: ooiqbabumxscpc-uhfffaoysa-n smiles cn(c)ccc1=cnc2=c1c=c(c=c2)ns(=o)(=o)c3=cc4=c(c=c3)c(=cc=c4)cl properties chemical formula c22h22cln3o2s molar mass 427.95 g/mol except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references one proposed mechanism of action is that e-6837 acts on neurons in the hypothalamus, which has shown significant levels of 5-ht6 receptor mrna. the hypothalamus is one key structure involved in regulating food intake.