estradiol acetate estradiol acetate estradiol acetate (ea), sold under the brand names femtrace, femring, and menoring, is an estrogen medication which is used in hormone therapy for the treatment of menopausal symptoms in women. it is taken by mouth once daily or given as a vaginal ring once every three months. estradiol acetateclinical datapronunciation/ˌɛstrəˈdaɪoʊl ˈæsəteɪt/es-trə-dy-ohl ass-ə-tayt trade namesfemtrace, femring, menoringother namesea; e2a; e3a; estradiol 3-acetateroutes ofadministrationby mouth, vaginal (ring)drug classestrogen; estrogen esteratc codeg03ca03 (who) legal statuslegal status in general: ℞ (prescription only) identifiers iupac name phenanthren-3-yl] acetate cas number4245-41-4pubchem cid9818306drugbankdb13952chemspider7994056unii5r97f5h93pkeggd04061chemblchembl1200430comptox dashboard (epa)dtxsid7045867 echa infocard100.167.088 chemical and physical dataformulac20h26o3molar mass314.425 g·mol−13d model (jsmol)interactive image smiles cc(=o)oc1=cc2=c(c=c1)3cc4((3cc2)cc4o)c inchi inchi=1s/c20h26o3/c1-12(21)23-14-4-6-15-13(11-14)3-5-17-16(15)9-10-20(2)18(17)7-8-19(20)22/h4,6,11,16-19,22h,3,5,7-10h2,1-2h3/t16-,17-,18+,19+,20+/m1/s1key:fhxbmxjmkmwvrg-slhncblasa-n side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. it is an estrogen ester and a prodrug of estradiol in the body. because of this, it is considered to be a natural and bioidentical form of estrogen. estradiol acetate was introduced for medical use in 2001. it is available in the united states and the united kingdom. the formulation for use by mouth has been discontinued in the united states. medical uses