trichlormethiazide trichlormethiazide trichlormethiazide (inn, currently being sold under the brand names of achletin, diu-hydrin and triflumen) is a diuretic with properties similar to those of hydrochlorothiazide. it is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. in veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. trichlormethiazideclinical dataahfs/drugs.commicromedex detailed consumer informationpregnancycategory b (d if used to treat pregnancy-induced hypertension) routes ofadministrationoral (capsules, tablets, oral solution)atc codec03aa03 (who) legal statuslegal status in general: ℞ (prescription only) pharmacokinetic databioavailabilityvariably absorbed from gi tractexcretionprimarily excreted unchanged in urineidentifiers iupac name 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2h-benzo thiadiazine-7-sulfonamide cas number133-67-5 ypubchem cid5560iuphar/bps7314drugbankdb01021 nchemspider5359 nuniiq58c92tun0keggd00658 nchemblchembl1054 ncomptox dashboard (epa)dtxsid7023699 echa infocard100.004.654 chemical and physical dataformulac8h8cl3n3o4s2molar mass380.64 g·mol−1 ny (what is this?) (verify) as a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body. trichlormethiazide works by inhibiting na+/cl− ion reabsorption from the distal tubules of the kidneys. in addition, trichlormethiazide increases the excretion of potassium. mechanism trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of henle. this results in excretion of sodium, chloride and water, and thus acts as a diuretic. although trichlormethiazide is used to treat hypertension, its hypotensive effects may not necessarily be due to its role as a diuretic. thiazides in general cause vasodilation by activating calcium-activated potassium channels in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. synthesis trichlormethiazide synthesis: