s-777,469 s-777,469 s-777,469 is a drug developed by shionogi which is a cannabinoid receptor agonist, with 128x selectivity for the cb2 subtype, having a cb2 affinity of 36nm, and a cb1 affinity over 4600nm. s-777,469clinical dataatc codenoneidentifiers iupac name 1--5-methyl-2-oxopyridine-3-carbonyl]amino]cyclohexane-1-carboxylic acid cas number885496-53-7pubchem cid57331749unii88ni79737ichemblchembl2019090chemical and physical dataformulac23h27fn2o4molar mass414.477 g·mol−13d model (jsmol)interactive image smiles ccc1=c(c=c(c(=o)n1cc2=cc=c(c=c2)f)c(=o)nc3(ccccc3)c(=o)o)c inchi inchi=1s/c23h27fn2o4/c1-3-19-15(2)13-18(20(27)25-23(22(29)30)11-5-4-6-12-23)21(28)26(19)14-16-7-9-17(24)10-8-16/h7-10,13h,3-6,11-12,14h2,1-2h3,(h,25,27)(h,29,30)key:jiyxojfspofzpy-uhfffaoysa-n in animal studies it showed antipruritic effects, and passed phase ii human trials for the treatment of atopic dermatitis, but development was ultimately not continued further.