melatonin receptor agonist melatonin receptor agonist melatonin receptor agonists are analogues of melatonin that bind to and activate the melatonin receptor. agonists of the melatonin receptor have a number of therapeutic applications including treatment of sleep disorders and depression. the discovery and development of melatonin receptor agonists was motivated by the need for more potent analogues than melatonin, with better pharmacokinetics and longer half-lives. melatonin receptor agonists were developed with the melatonin structure as a model. melatonin receptor agonistdrug classmelatonin, the prototypical melatonin receptor agonistclass identifiersusesleep disorders, depression, adhd, etc.atc coden05chbiological targetmelatonin receptorclinical datawebmdrxlist