alclometasone alclometasone alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties. alclometasoneclinical datatrade namesaclovateahfs/drugs.commonographmedlineplusa604021routes ofadministrationtopicalatc coded07ab10 (who) s01ba10 (who)legal statuslegal status us: ℞-only pharmacokinetic databioavailability3% systemically (topical)metabolismhepaticonset of actioneczema: 5.3 - 13.9 days; psoriasis: 6.7 - 14.8 days identifiers iupac name (7r,8s,9s,10r,11s,13s,14s,16r,17r)-7-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopentaphenanthren-3-one cas number67452-97-5 ypubchem cid5311000drugbankdb00240 ychemspider4470541 yunii136h45tb7bchebichebi:53776 ychemblchembl1201361 nchemical and physical dataformulac22h29clo5molar mass408.92 g·mol−13d model (jsmol)interactive image smiles c1c23(cc4=cc(=o)c=c4(3(c2(1(c(=o)co)o)c)o)c)cl inchi inchi=1s/c22h29clo5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28h,6,8-10h2,1-3h3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1 ykey:fjxogvlkczqrdn-phchrakrsa-n y ny (what is this?) (verify) the prodrug alclometasone dipropionate was originally marketed under the brand name aclovate by glaxosmithkline as a topical cream and ointment. however, generic versions of the drug are available. medical uses alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including: atopic dermatitis eczema psoriasis allergic dermatitis contact dermatitis actinic dermatitis kiss-type allergy skin itch alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients. contraindications hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms cutaneous tuberculosis chicken pox perioral dermatitis acne rosacea open wounds trophic ulcers viral infection of skin skin manifestations of syphilis side effects adverse reactions (sometimes, less than 1-2% cases) include: burning itching erythema skin reddening xerodermia skin irritation acne hypopigmentation prickly heat folliculitis white atrophy hypertrichosis reinfection of skin pharmacology alclometasone induces the production of lipocortins, formally known as annexins, which inhibit phospholipase a2 – the enzyme responsible for the synthesis of arachidonic acid. without the oxidation of arachidonic acid, eicosanoids, such as prostaglandins, thromboxanes, and leukotrienes, can't be produced. alclometasone also inhibits the release of pro-inflammatory mediators from leukocytes (e.g., cytokines, histamine, leukotrienes, serotonin). formulations alclometasone as aclovate is supplied in: cream; topical; 0.05% ointment; topical; 0.05%