progressive disseminated histoplasmosis progressive disseminated histoplasmosis progressive disseminated histoplasmosis is an infection caused by histoplasma capsulatum, and most people who develop this severe form of histoplasmosis are immunocompromised or taking systemic corticosteroids.: 316 skin lesions are present in approximately 6% of patients with dissemination.: 316 progressive disseminated histoplasmosisspecialtyinfectious disease