In this task, you are given a question and a context passage. You have to answer the question based on the given passage.

What needs to decrease before pituitary growth hormone can increase in the blood?, Context: In addition to the negative consequences of sleep deprivation, sleep and the intertwined circadian system have been shown to have strong regulatory effects on immunological functions affecting both the innate and the adaptive immunity. First, during the early slow-wave-sleep stage, a sudden drop in blood levels of cortisol, epinephrine, and norepinephrine induce increased blood levels of the hormones leptin, pituitary growth hormone, and prolactin. These signals induce a pro-inflammatory state through the production of the pro-inflammatory cytokines interleukin-1, interleukin-12, TNF-alpha and IFN-gamma. These cytokines then stimulate immune functions such as immune cells activation, proliferation, and differentiation. It is during this time that undifferentiated, or less differentiated, like naïve and central memory T cells, peak (i.e. during a time of a slowly evolving adaptive immune response). In addition to these effects, the milieu of hormones produced at this time (leptin, pituitary growth hormone, and prolactin) support the interactions between APCs and T-cells, a shift of the Th1/Th2 cytokine balance towards one that supports Th1, an increase in overall Th cell proliferation, and naïve T cell migration to lymph nodes. This milieu is also thought to support the formation of long-lasting immune memory through the initiation of Th1 immune responses.
cortisol, epinephrine, and norepinephrine

What shouldn't be much of a worry?, Context: Vinyl records can be warped by heat, improper storage, exposure to sunlight, or manufacturing defects such as excessively tight plastic shrinkwrap on the album cover. A small degree of warp was common, and allowing for it was part of the art of turntable and tonearm design. "wow" (once-per-revolution pitch variation) could result from warp, or from a spindle hole that was not precisely centered. Standard practice for LPs was to place the LP in a paper or plastic inner cover. This, if placed within the outer cardboard cover so that the opening was entirely within the outer cover, was said to reduce ingress of dust onto the record surface. Singles, with rare exceptions, had simple paper covers with no inner cover.
A small degree of warp

Who was not a count, Baldwin or John Softsword?, Context: After his coronation, John moved south into France with military forces and adopted a defensive posture along the eastern and southern Normandy borders. Both sides paused for desultory negotiations before the war recommenced; John's position was now stronger, thanks to confirmation that the counts Baldwin IX of Flanders and Renaud of Boulogne had renewed the anti-French alliances they had previously agreed to with Richard. The powerful Anjou nobleman William des Roches was persuaded to switch sides from Arthur to John; suddenly the balance seemed to be tipping away from Philip and Arthur in favour of John. Neither side was keen to continue the conflict, and following a papal truce the two leaders met in January 1200 to negotiate possible terms for peace. From John's perspective, what then followed represented an opportunity to stabilise control over his continental possessions and produce a lasting peace with Philip in Paris. John and Philip negotiated the May 1200 Treaty of Le Goulet; by this treaty, Philip recognised John as the rightful heir to Richard in respect to his French possessions, temporarily abandoning the wider claims of his client, Arthur.[nb 4] John, in turn, abandoned Richard's former policy of containing Philip through alliances with Flanders and Boulogne, and accepted Philip's right as the legitimate feudal overlord of John's lands in France. John's policy earned him the disrespectful title of "John Softsword" from some English chroniclers, who contrasted his behaviour with his more aggressive brother, Richard.

John Softsword

