In this task, you are given a text of many news articles seperated by special token "|||||". Your task is to summarize them.

It's a SIRT 
  
 Intense attention has focused on the SIRT1 deacetylase as a possible target for anti-aging drugs. But unexpected complications in assays of SIRT1 activity have made it unclear whether compounds thought to be sirtuin-activating compounds (STACs) are really direct regulators of the enzyme. Further exploration of these effects by Hubbard et al. (p. 1216; see the Perspective by Yuan and Marmorstein) revealed that interaction of SIRT1 with certain substrates allows activation of SIRT1 by STACs and identified critical amino acids in SIRT1 required for these effects. Mouse myoblasts reconstituted with SIRT1 mutated at this amino acid lost their responsiveness to STACs. ||||| New drug being developed using compound found in red wine 'could help humans live until they are 150' 
  
 Drugs are synthetic versions of resveratrol, found in red wine 
  
 Research shows drugs which could prevent cancer and diabetes now viable 
  
 Medication can be taken topically or orally 
  
 No drugs yet developed to target aging skin 
  
  
  
 Breakthrough: The new anti-aging drugs are synthetic versions of resveratrol which is found in red wine 
  
 Drugs that could combat ageing and help people to live to 150-years-old may be available within five years, following landmark research. 
  
 The new drugs are synthetic versions of resveratrol which is found in red wine and is believed to have an anti-ageing effect as it boosts activity of a protein called SIRT1. 
  
  
  
 Pharmaceutical giant GlaxoSmithKline has been testing the medications on patients suffering with medical conditions including cancer, diabetes and heart disease. 
  
  
  
 The work proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans. 
  
 As each of the 117 drugs tested work on the single enzyme through a common mechanism is means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer's disease and type 2 diabetes. 
  
 Genetics professor David Sinclair, based at Harvard University, said: 'Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others. 
  
 'In effect, they would slow ageing.' 
  
 The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators. 
  
 The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed. 
  
 Although research surrounding resveratrol has been going on for a decade, until now the basic science had been contested. 
  
 Despite this, there have already been promising results in some trials with implications for cancer, cardiovascular disease and cardiac failure, type 2 diabetes, Alzheimer's and Parkinson's diseases, fatty liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders and inflammatory diseases such as psoriasis, arthritis and colitis. 
  
  
  
 Professor Sinclair said: 'In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster.' 
  
 Positive: Scientists have been testing the medications on patients suffering with medical conditions including cancer, diabetes and heart disease (file picture) 
  
 The technology was sold to GlaxoSmithKline in 2008. 
  
  
  
 Four thousand synthetic activators, which are 100 times as potent as a single glass of red wine, have been developed - with the best three being used in human trials. 
  
 Writing in the journal Science, Professor Sinclair, who suggests the first therapeutic to be marketed will be for diabetes, said: 'Our drugs can mimic the benefits of diet and exercise, but there is no impact on weight.' 
  
 Limited trials have been carried out in people with type 2 diabetes and the skin inflammatory disease, psoriasis. 
  
  
  
 Scientists found that there were benefits to the metabolism in the first group and a reduction in skin redness in the second. 
  
 The drugs can be administered orally, or topically. 
  
  
  
 So far, there have been no drugs developed to target ageing skin, but one major skin care range has developed a creme with resveratrol in it. 
  
 Anti-aging: Drugs to target ageing skin have not yet been developed, but one major skin care range has created a creme containing resveratrol 
  
 While any drug would be strictly prescribed for certain conditions, Professor Sinclair suggests that one day, they could be taken orally as a preventative. 
  
 They could therefore be used in the same way as statin drugs are commonly prescribed to prevent, instead of simply treating, cardiovascular disease. 
  
 In animal models, overweight mice given synthetic resveratrol were able to run twice as far as slim mice and they lived 15 per cent longer. 
  
 Professor Sinclair added: 'Now we are looking at whether there are benefits for those who are already healthy. 
  
 'Things there are also looking promising. We're finding that ageing isn't the irreversible affliction that we thought it was. |||||
You've no doubt heard that drinking red wine is good for your health. But scientists and Big Pharma alike are getting excited about putting the health-boosting essence of red wine in pill form. GlaxoSmithKline is working on a slew of new pills that do just that, the Daily Mail reports, after a recent study in the journal Science showed the huge potential of resveratrol, a chemical found in red wine. Resveratrol activates a protein called SIRT1, which is believed to have an anti-aging effect. "Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others," one Harvard geneticist explains. "In effect, they would slow aging." The most recent studies show the drug could help treat a host of illnesses, from cancer to Alzheimer's to type 2 diabetes. GlaxoSmithKline has developed around 4,000 synthetic forms of the activator, each 100 times more potent than a glass of red wine, and is already testing three in human trials. In animal trials, they extended the lifespans of overweight mice by 15%.