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In this task, you are given a text of many news articles seperated by special token "|||||". Your task is to summarize them.

You wouldn't think chili peppers and marijuana have much in common. But when eaten, both interact with the same receptor in our stomachs, according to a paper by UConn researchers published in the April 24 issue of the journal Proceedings of the National Academy of Sciences. The research could lead to new therapies for diabetes and colitis, and opens up intriguing questions about the relationship between the immune system, the gut and the brain. 
  
 Touch a chili pepper to your mouth and you feel heat. And biochemically, you aren't wrong. The capsaicin chemical in the pepper binds to a receptor that triggers a nerve that fires off to your brain: hot! Those same receptors are found throughout the gastrointestinal tract, for reasons that have been mysterious. 
  
 Curious, UConn researchers fed capsaicin to mice, and found the mice fed with the spice had less inflammation in their guts. The researchers actually cured mice with Type 1 diabetes by feeding them chili pepper. When they looked carefully at what was happening at a molecular level, the researchers saw that the capsaicin was binding to a receptor called TRPV1, which is found on specialized cells throughout the gastrointestinal tract. When capsaicin binds to it, TRPV1 causes cells to make anandamide. Anandamide is a compound chemically akin to the cannabinoids in marijuana. It was the anandamide that caused the immune system to calm down. And the researchers found they could get the same gut-calming results by feeding the mice anandamide directly. 
  
 The brain also has receptors for anandamide. It's these receptors that react with the cannabinoids in marijuana to get people high. Scientists have long wondered why people even have receptors for cannabinoids in their brains. They don't seem to interact with vital bodily functions that way opiate receptors do, for example. 
  
 "This allows you to imagine ways the immune system and the brain might talk to each other. They share a common language," says Pramod Srivastava, Professor of Immunology and Medicine at UConn School of Medicine. And one word of that common language is anandamide. 
  
 Srivastava and his colleagues don't know how or why anandamide might relay messages between the immune system and the brain. But they have found out the details of how it heals the gut. The molecule reacts with both TRPV1 (to produce more anandamide) and another receptor to call in a type of macrophage, immune cells that subdue inflammation. The macrophage population and activity level increases when anandamide levels increase. The effects pervade the entire upper gut, including the esophagus, stomach and pancreas. They are still working with mice to see whether it also affects disorders in the bowels, such as colitis. And there are many other questions yet to be explored: what is the exact molecular pathway? Other receptors also react with anandamide; what do they do? How does ingesting weed affect the gut and the brain? 
  
 It's difficult to get federal license to experiment on people with marijuana, but the legalization of pot in certain states means there's a different way to see if regular ingestion of cannabinoids affects gut inflammation in humans. 
  
 "I'm hoping to work with the public health authority in Colorado to see if there has been an effect on the severity of colitis among regular users of edible weed," since pot became legal there in 2012, Srivastava says. If the epidemiological data shows a significant change, that would make a testable case that anandamide or other cannabinoids could be used as therapeutic drugs to treat certain disorders of the stomach, pancreas, intestines and colon. 
  
 It seems a little ironic that both chili peppers and marijuana could make the gut chill out. But how useful if it's true. 
  
 ### ||||| If your gut is giving you a hard time, eating a whole bunch of spicy food and a pot brownie for dessert may sound like the worst idea in the world. But as counterintuitive as that might sound, new research suggests that your body might find this combo a salve for an irritated digestive tract. 
  
 Researchers with the University of Connecticut School of Medicine have discovered a surprising new function for chemicals found in hot peppers and marijuana in calming inflammation in the digestive tract, which could lead to new treatments for Type 1 diabetes, colitis, and other disorders that put the gut function out of whack. The study was published Monday in the Proceedings of the National Academy of Sciences. 
  
 Here’s how it works: Capsaicin, the chemical that gives hot peppers their heat, binds to special receptors in your digestive tract, and the result of this holy union is the production of a chemical called anandamide, an endogenous cannabinoid and chemically similar to the stuff in weed that gets you high — but produced from within your own body. 
  
 Anandamide, as it turns out, binds to another receptor in your digestive tract, stimulating the production and function of a certain type of white blood cell called a macrophage that lowers immune response and therefore limits inflammation. When researchers fed hot chilies to mice with Type 1 diabetes, they had a protective effect that essentially cured the animals of the disease. Giving the mice anandamide directly produced the same effect. 
  
 Eating marijuana products would likely deliver the same result, and it’s something researchers will be investigating. 
  
 “I’m hoping to work with the public health authority in Colorado to see if there has been an effect on the severity of colitis among regular users of edible weed,” says senior author Pramod Srivastava. “If the epidemiological data shows a significant change [since marijuana legalization in 2012], that would make a testable case that anandamide or other cannabinoids could be used as therapeutic drugs to treat certain disorders of the stomach, pancreas, intestines, and colon.” 
  
 The same receptors that cannabinoids binds to in the gut also exist in your brain, and it is activity here that ultimately gets you stoned. Why these receptors in the brain exist at all remains a medical mystery, but this new research unlocks a piece of the puzzle. 
  
 This study shows for the first time a major immune function for cannabinoids, and it could be that your digestive system and your nervous system are engaged in a bit of a biological conversation based on these shared receptors, Srivastava posits. 
  
 This anti-inflammatory property could help explain why spicy foods have been statistically linked to longer lifespans in China. 
  
 Eating a hot curry for dinner with a weed cookie for dessert might be just what the doctor ordered. Just don’t get confused and put hot peppers in your bong instead — that’s still stupid. 
  
 Photos via Eric in SF / Wikimedia |||||
Output:
Have an upset stomach? A new study suggests that chili peppers and perhaps a pot brownie might help. It may sound bizarre, but researchers at the University of Connecticut found that a chemical in chili peppers played a role in the calming the gut, at least in mice. What's more, there's a parallel to pot. The scientists discovered that the chemical that gives chili peppers their heat, capsaicin, was binding to receptors in the gastrointestinal tract, explains Inverse. The combination produced the chemical anandamide, similar to the cannabinoids in marijuana that get you stoned, and the resulting anandamide eased inflammation in the esophagus, stomach, and pancreas. Researchers saw the same effect when they gave the mice anandamide directly, which leads them to believe that edible marijuana may also have a calming effect on the gut. Because there's a lot of red tape surrounding marijuana research, "I'm hoping to work with the public health authority in Colorado to see if there has been an effect on the severity of colitis among regular users of edible weed," study author Pramod Srivastava says in a release. If the findings hold up, it suggests that anandamide and other cannabinoids could be used to treat colitis, diabetes, and other issues of the stomach, pancreas, intestines, and colon. (A ghost pepper, however, is unlikely to soothe.)