Given the task definition and input, reply with output. In this task, we ask you to elaborate the sentence without changing its general meaning. You can do so by explaining further the input sentence, using more precise wording, adding qualifiers and auxiliary information etc.

Sulfonamide drugs were the first antimicrobial drugs .

Sulfonamide drugs were the first antibacterials to be used systemically , and paved the way for the antibiotic revolution in medicine .