You will be given a passage, and your task is to generate a Yes/No question that is answerable based on the given passage.

Q: Common constitutional signs and symptoms of the HFMD include fever, nausea, vomiting, feeling tired, generalized discomfort, loss of appetite, and irritability in infants and toddlers. Skin lesions frequently develop in the form of a rash of flat discolored spots and bumps which may be followed by vesicular sores with blisters on palms of the hands, soles of the feet, buttocks, and sometimes on the lips. The rash is rarely itchy for children, but can be extremely itchy for adults. Painful facial ulcers, blisters, or lesions may also develop in or around the nose or mouth. HFMD usually resolves on its own after 7--10 days. Most cases of the disease are relatively harmless, but complications including encephalitis, meningitis, and paralysis that mimics the neurological symptoms of polio can occur.

A: do you itch with hand foot and mouth?
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Q: A stipulation that this kick must be towards the opponents' goal existed in the rules from 1883 until 2016. This resulted in kick-offs typically involving two people (as pictured), with one tapping the ball forward and the other passing it back to the rest of the team. Now a team may kick the ball backwards explaining why the kicker may be in the other half of the field when kicking the ball.

A: do you have to kick the ball forward at kick off?
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Q: The Grand Canyon of northern Arizona in the United States, with an average depth of 1,600 m (one mile) and a volume of 4.17 trillion cubic metres, is one of the world's largest canyons. It was among the 28 finalists of the New7Wonders of Nature worldwide poll. (Some referred to it as one of the 7 natural wonders of the world.) Copper Canyon in Chihuahua, Mexico is deeper and longer than the Grand Canyon.

A:
is the grand canyon the second largest canyon in the world?
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