Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Example Input: The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.
Example Output: adverse drug event

Example Input: Tigecycline is a broad-spectrum antimicrobial agent structurally related to minocycline.
Example Output: non-adverse drug event

Example Input: Type I, blue-black pigmentation confined to sites of scarring or inflammation on the face; Type II, blue-grey circumscribed pigmentation of normal skin of the lower legs and forearms; and Type III, diffuse muddy brown pigmentation of normal skin accentuated in sun-exposed areas.
Example Output:
non-adverse drug event

