Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: People have been using sound to make music for thousands of years. They have invented many different kinds of musical instruments for this purpose. Despite their diversity, however, musical instruments share certain similarities. All musical instruments create sound by causing matter to vibrate. The vibrations start sound waves moving through the air. Most musical instruments use resonance to amplify the sound waves and make the sounds louder. Resonance occurs when an object vibrates in response to sound waves of a certain frequency. In a musical instrument such as a guitar, the whole instrument and the air inside it may vibrate when a single string is plucked. This causes constructive interference with the sound waves, which increases their amplitude. Most musical instruments have a way of changing the frequency of the sound waves they produce. This changes the pitch of the sounds. There are three basic categories of musical instruments: percussion, wind, and stringed instruments. In Figure Researchers at Lawrence Berkeley National Laboratory are pioneering a new way to recover 100-year-old record- ings. Found on fragile wax cylinders and early lacquer records, the sounds reveal a rich acoustic heritage, including languages long lost. For more information on how to recover recordings, see [Link] MEDIA Click image to the left or use the URL below. URL: Ultrasound has frequencies higher than the human ear can detect (higher than 20,000 hertz). Although we cant hear ultrasound, it is very useful. Uses include echolocation, sonar, and ultrasonography. Animals such as bats, whales, and dolphins send out ultrasound waves and use their echoes, or reflected waves, to identify the locations of objects they cannot see. This is called echolocation. Animals use echolocation to find prey and avoid running into objects in the dark. Figure 20.13 and the animation at the URL below show how a bat uses echolocation to locate insect prey. Sonar uses ultrasound in a way that is similar to echolocation. Sonar stands for sound navigation and ranging. It is used to locate underwater objects such as sunken ships or to determine how deep the water is. A sonar device is usually located on a boat at the surface of the water. The device is both a sender and a receiver (see Figure 20.14). It sends out ultrasound waves and detects reflected waves that bounce off underwater objects or the bottom of the water. If you watch the video at the URL below, you can see how sonar is used on a submarine. The distance to underwater objects or the bottom of the water can be calculated from the known speed of sound in water and the time it takes for the waves to travel to the object. The equation for the calculation is: Distance = Speed Time Assume, for example, that a sonar device on a ship sends an ultrasound wave to the bottom of the ocean. The speed of the sound through ocean water is 1437 m/s, and the wave travels to the bottom and back in 2 seconds. What is the distance from the surface to the bottom of the water? The sound wave travels to the bottom and back in 2 seconds, so it travels from the surface to the bottom in 1 second. Therefore, the distance from the surface to the bottom is: Distance = 1437 m/s 1 s = 1437 m You Try It! Problem: The sonar device on a ship sends an ultrasound wave to the bottom of the water at speed of 1437 m/s. The wave is reflected back to the device in 4 seconds. How deep is the water? Ultrasound can be used to "see" inside the human body. This use of ultrasound is called ultrasonography. Harmless ultrasound waves are sent inside the body, and the reflected waves are used to create an image on a screen. This technology is used to examine internal organs and unborn babies without risk to the patient. You can see an ultrasound image in Figure 20.15. You can see an animation showing how ultrasonography works at this URL: In this QUEST web extra, Stanford University astrophysicist Todd Hoeksema explains how solar sound waves are a vital ingredient to the science of helioseismology, in which the interior properties of the sun

Answer: use of ultrasound to locate underwater objects


Question: Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder resulting in the growth of a variety of tumours, and is inherited in an autosomal dominant pattern. Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that commonly harbour oncogenic mutations in KIT or PDGFRA and are thought to arise from the interstitial cells of Cajal (ICC; the pacemaker cells of the gut). To characterise two patients with NF1 and GISTs. Two patients were genotyped for germline mutations in NF1. GISTs from both patients were genotyped for somatic mutations in KIT and PDGFRA. Loss of heterozygosity (LOH) of NF1 in one GIST was assessed by genotyping seven microsatellite markers spanning 2.39 Mb of the NF1 locus in the tumour and in genomic DNA. The known germline mutation in NF1 was confirmed in GIST DNA by sequencing. The copy number of the mutated NF1 allele was determined by multiplex ligand-dependent probe amplification. GISTs from both patients were of wild type for mutations in KIT and PDGFRA. In the GIST with adequate DNA, all seven markers were informative and showed LOH at the NF1 locus; sequencing of NF1 from that GIST showed no wild-type sequence, suggesting that it was lost in the tumour. Multiplex ligand-dependent probe amplification analysis showed that two copies of all NF1 exons were present. This is the first evidence of mitotic recombination resulting in a reduction to homozygosity of a germline NF1 mutation in an NF1-associated GIST. We hypothesise that the LOH of NF1 and lack of KIT and PDGFRA mutations are evidence of an alternative pathogenesis in NF1-associated GISTs.

Answer: Which is the gene mutated in type 1 neurofibromatosis?


Question: The Beijing Railway Station opened in 1959 and was the largest train station in China at the time.

Answer:
When was Beijing Railway Station started?


