Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we determined effects of the SGLT2 inhibitor empagliflozin (300 mg/kg of diet for 15 wk; corresponding to 60-80 mgkg(-1)day(-1)) in type 1 diabetic Akita mice that, opposite to streptozotocin-diabetes, upregulate renal SGLT2 expression. Akita diabetes, empagliflozin, and Akita + empagliflozin similarly increased renal membrane SGLT2 expression (by 38-56%) and reduced the expression of SGLT1 (by 33-37%) vs. vehicle-treated wild-type controls (WT). The diabetes-induced changes in SGLT2/SGLT1 protein expression are expected to enhance the BG-lowering potential of SGLT2 inhibition, and empagliflozin strongly lowered BG in Akita (means of 187-237 vs. 517-535 mg/dl in vehicle group; 100-140 mg/dl in WT). Empagliflozin modestly reduced GFR in WT (250 vs. 306 l/min) and completely prevented the diabetes-induced increase in glomerular filtration rate (GFR) (255 vs. 397 l/min). Empagliflozin attenuated increases in kidney weight and urinary albumin/creatinine ratio in Akita in proportion to hyperglycemia. Empagliflozin did not increase urinary glucose/creatinine ratios in Akita, indicating the reduction in filtered glucose balanced the inhibition of glucose reabsorption. Empagliflozin attenuated/prevented the increase in systolic blood pressure, glomerular size, and molecular markers of kidney growth, inflammation, and gluconeogenesis in Akita. We propose that SGLT2 inhibition can lower GFR independent of reducing BG (consistent with the tubular hypothesis of diabetic glomerular hyperfiltration), while attenuation of albuminuria, kidney growth, and inflammation in the early diabetic kidney may mostly be secondary to lower BG.
[A]: Which protein does empagliflozin inhibit?


[Q]: One day, a slave owner entered a local store and threatened a young boy who was his slave. At first, the slave refused to move and ran for the door. The slave owner reached for a heavy weight. He threw it at his slave. Instead, it hit Harriet on the head. Harriet almost died. For the rest of her life, she carried the mark of a deep wound on her head. Miser Brodas felt he never needed Harriet. He decided to sell her. Harriet thought of a way to prevent this. Each time she was shown to someone who might buy her, she acted as if she were falling asleep. After a while, Mister Brodas gave up the hope of selling Harriet. He sent her back to the fields. At 24 she married a free black man, John Tubman. By then, Harriet was sure she should escape. In 1849, Mister Brodas died. His slaves probably would be sold to further South. John Tubman tried to make Harriet forget about running away. Harriet decided she must end her marriage and that she needed to tell her family that she was leaving. Harriet escaped for Pennsylvania where slavery was banned there. Once she hid under hay that had been cut from the fields. Another time, she wore men's clothing. Finally, she arrived in Pennsylvania. Now that Harriet was free, she didn't forget other slaves in Maryland. During the next ten years, she freed her parents and other family members. She traveled back and forth eighteen times, helping about 300 slaves escape. She became an expert at hiding from slave hunters. At one time, anyone finding Harriet was promised 40,000dollars for catching her--dead or alive. The people she helped called her Moses. She had rescued them from slavery just as the biblical Moses rescued the Jews. After the Civil War began, Harriet started to spy for the North. She also served as a nurse. After four years of bloody fighting, the North won the war. Abraham Lincoln freed the slaves in 1863. There was no longer any need for Harriet to be Moses.
[A]: We know from the passage that Harriet was Mister Brodas'    .


[Q]: Several properties of the atmosphere change with altitude, but the composition of the natural gases does not. The proportions of gases in the atmosphere are everywhere the same, with one exception. At about 20 km to 40 km above the surface, there is a greater concentration of ozone molecules than in other portions of the atmosphere. This is called the ozone layer. Nitrogen and oxygen together make up 99% of the planets atmosphere. Nitrogen makes up the bulk of the atmosphere, but is not involved in geological or biological processes in its gaseous form. Nitrogen fixing is described in the chapter Life on Earth. Oxygen is extremely important because it is needed by animals for respiration. The rest of the gases are minor components but sometimes are very important (Figure 1.1). Nitrogen and oxygen make up 99% of the atmosphere; carbon dioxide is a very important minor component. Humidity is the amount of water vapor in the air. Humidity varies from place to place and season to season. This fact is obvious if you compare a summer day in Atlanta, Georgia, where humidity is high, with a winter day in Phoenix, Arizona, where humidity is low. When the air is very humid, it feels heavy or sticky. Dry air usually feels more comfortable. When humidity is high, water vapor makes up only about 4% of the atmosphere. Where around the globe is mean atmospheric water vapor higher and where is it lower (Figure 1.2)? Why? Higher humidity is found around the equatorial regions because air temperatures are higher and warm air can hold more moisture than cooler air. Of course, humidity is lower near the polar regions because air temperature is lower. Remember that greenhouse gases trap heat in the atmosphere. Important natural greenhouse gases include carbon dioxide, methane, water vapor, and ozone. CFCs and some other man-made compounds are also greenhouse gases. Some of what is in the atmosphere is not gas. Particles of dust, soil, fecal matter, metals, salt, smoke, ash, and other solids make up a small percentage of the atmosphere and are called particulates. Particles provide starting points (or nuclei) for water vapor to condense on and form raindrops. Some particles are pollutants. Click image to the left or use the URL below. URL:
[A]:
humidity is how much of this is in the air.


