TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Rigel Pharmaceuticals Inc is developing fostamatinib, a prodrug of the spleen tyrosine kinase (Syk) inhibitor R-406, for the potential treatment of autoimmune diseases such as rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and B-cell lymphomas. Syk is a key mediator of Fc and B-cell receptor signaling in inflammatory cells, such as B-cells, mast cells, macrophages and neutrophils. Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. In a phase II clinical trial, fostamatinib treatment effectively improved American College of Rheumatology response rates in patients with RA. Preclinical studies and phase II trials also suggested the potential of using fostamatinib for the treatment of ITP and B-cell lymphomas, by increasing platelet counts and inducing response rates, respectively. Fostamatinib is orally bioavailable and was well tolerated in phase I and II trials, with the most common side effect being gastrointestinal symptoms. At the time of publication, phase II trials for fostamatinib were ongoing in patients with RA, ITP and B-cell lymphomas. The Syk inhibitor appears to be a promising therapeutic for immunological diseases, but further data are required to establish the efficacy and long-term safety of the drug in humans.

SOLUTION: Which enzyme is inhibited by a drug fostamatinib?

PROBLEM: This March is a busy month in Shanghai.There's a lot to do.Here are the highlights. Live Music - Late Night Jazz Enjoy real American jazz from Herbie Davis, the famous trumpet player.He's coming with his new 7-piece band, Herbie's Heroes.Herbie is known to play well into the early hours, so don't expect to get much sleep.This is Herbie's third visit to Shanghai.The first two were sold out, so get your tickets quickly. PLACE: The Jazz Club DATES: 15---23 March PRICE: Y=80,120 TIME: 10:00p.m.till late! TEL: 6466--8736 Scottish dancing Take your partners and get ready to dance till you drop.Scottish dancing is fun and easy to learn.Instructors will demonstrate the dances.The live band, Gordon Stroppie and the Weefrees, are also excellent. PLACE: Jack Stein's DATES: every Monday PRICE: Y60 including one drink TIME: 7:00 ---0:00 p.m. TEL: 6402-1877 Exhibitions - Shanghai Museum There are 120,000 pieces on show here.You can see the whole of Chinese history under one roof.It's always interesting to visit, but doubly so at the moment with the Egyptian Tombs exhibition.There are lots of mummies and more gold than you've ever seen before.Let us know if you see a mummy move! PLACE: Shanghai Museum PRICE: Y=30 (Y= 15 for students) TEL: 6888-6888 DATES: daily TIME: Monday - Friday 9:00a.m.- 5:00p.m., Weekends 9:00a.m.--- 9:00p.m. Dining - Sushi chef in town Sushi is getting really big in Shanghai.In Japan, it's become an art form.The most famous Sushi 'artist' is Yuki Kamura.She's also one of the few female chefs in Japan.She'll be at Sushi Scene all of this month. PLACE: Sushi Scene in the Shanghai Hotel DATES: all month PRICE: Y=200 TIME: lunchtime TEL: 6690-3211 For a full listing of events, see our website.

SOLUTION: Suppose you are going to attend an activity at 8: 00p.m.on Saturday, which one can   you choose?

PROBLEM: Lake Champlain Chocolates (LCC) is a privately held chocolate manufacturer located in Burlington, Vermont, USA.

SOLUTION:
What is the city where Lake Champlain Chocolates is from?

