Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Ian Lafferty (Josh Zuckerman) is an 18-year-old recent high school graduate. He searches for a girl online making it seem as if he is attractive and strong, although he's sweet and unassuming. He soon meets "Ms. Tasty" (Katrina Bowden) and agrees to meet her in person. She lives in Knoxville, Tennessee, while he lives in Chicago, Illinois. With his best friends Lance Nesbitt (Clark Duke) and Felicia Alpine (Amanda Crew), he goes to Knoxville in a 1969 Pontiac GTO Judge borrowed without permission from Ian's arrogant homophobic older brother Rex (James Marsden). On the way to Knoxville, they come across a hitchhiker (David Koechner), as the radiator in the Judge overheats. They attempt urinating in the radiator, which only works briefly as they try to leave the hitchhiker in the dust. The hitchhiker, frustrated at Ian's lack of concern for his well being, leaves, but not before urinating on the car window. As Ian and Felicia wander to find help, Lance is waiting with the car as Ezekiel (Seth Green) happens to pass by in his horse-drawn buggy. Ezekiel and his Amish buddies repair the car while they join a Rumspringa party where Fall Out Boy are playing a concert, and at which Lance meets an attractive Amish girl, Mary (Alice Greczyn). The three promise to come again on the way back to do some work in return for fixing the car. They go to jail due to Ian throwing a tire iron into a state trooper car, due to his increasing frustration after trying to put a possum he hit out of its misery, and are released after Mary pays the bail. Upon arriving at Knoxville, they find a hotel that sports a wide variety of role playing rooms. Rex, who has discovered the Judge gone missing, arrives angrily and insists that they go back and that Ian cannot visit Ms. Tasty. After Ian pretends to be gay, Rex allows him to see Ms. Tasty, hoping this encounter will change Ian's mind. Ian finally meets Ms. Tasty. However, when he tells her about Felicia, her seduction for Ian to take off his clothes becomes a threat as her psychotic boyfriend Bobby Jo (Dave Sheridan) puts a gun to Ian's head. It becomes apparent that they work at a chop shop and attempt to steal the Judge. Lance and Mary arrive after having sex, as well as a redneck named Rick (Michael Cudlitz) whose girlfriend Brandy (Andrea Anders) slept with Lance earlier. Felicia, however, is hiding in the car when Bobby Jo tries to steal it. Soon, a green car that has been continuously drag-racing with the Judge throughout the movie arrives. Ian manages to save Felicia, who then is able to run off and report to the police. Ms. Tasty tries to escape, but is stopped by the green car, whose drivers turn out to be Andy and Randy (Charlie McDermott and Mark L. Young), two dim-witted self-declared "womanizers" from Ian's school, who Ms. Tasty tried to manipulate into giving her the car. Bobby Jo is treated after being shot by Ian in self-defense. Felicia tells the police about the chop shop location and the couple is arrested. Upon finding out that if Mary leaves the Amish community, she will be shunned, Lance refuses to come back home and stays behind to marry Mary, while Ian and Felicia realize their love for each other. Ian and Felicia drive to a tree where Ian throws his shoes up into the tree. A few weeks later Ian is Felicia's date to her cousin's wedding. At Thanksgiving dinner, Rex tells his family that he's gay. On New Year's Eve Ian and Felicia finally have sex, in Ian's basement under a blanket on the sofa. In the final frame of the film, a picture is shown of Lance and Mary getting married, accompanied by Ian. Lance is shown sporting a beard exactly like Ezekiel's. During the credits, a short scene is shown of Ezekiel and Fall Out Boy arguing over the fact that the

Ex Output:
Who does Ian shoot?


Ex Input:
In the Atlantic, the West India Company concentrated on wresting from Portugal its grip on the sugar and slave trade, and on opportunistic attacks on the Spanish treasure fleets on their homeward bound voyage. Bahia on the north east coast of Brazil was captured in 1624 but only held for a year before it was recaptured by a joint Spanish-Portuguese expedition. In 1628, Piet Heyn captured the entire Spanish treasure fleet, and made off with a vast fortune in precious metals and goods that enabled the Company two years later to pay its shareholders a cash dividend of 70%, though the Company was to have relatively few other successes against the Spanish. In 1630, the Dutch occupied the Portuguese sugar-settlement of Pernambuco and over the next few years pushed inland, annexing the sugar plantations that surrounded it. In order to supply the plantations with the manpower they required, a successful expedition was launched in 1637 from Brazil to capture the Portuguese slaving post of Elmina, and in 1641 successfully captured the Portuguese settlements in Angola. In 1642, the Dutch captured the Portuguese possession of Axim in Africa. By 1650, the West India Company was firmly in control of both the sugar and slave trades, and had occupied the Caribbean islands of Sint Maarten, Curacao, Aruba and Bonaire in order to guarantee access to the islands' salt-pans.

Ex Output:
What were two things the West India Company desired?


Ex Input:
Chronic myeloid leukaemia (CML) is characterized cytogenetically by a t(9;22)(q34;ql1) reciprocal translocation which gives origin to a hybrid BCR-ABL gene, encoding a p2lO(BCR-ABL) fusion protein with elevated tyrosine kinase activity and transforming abilities. The t(9;22) was suggested to be associated with genomic imprinting of centromeric regions of chromosomes 9 and 22, but the genes directly affected by the translocation, ABL and BCR, were shown not to be imprinted. For most diagnostic and research purposes the BCR-ABL gene can be efficiently identified by reverse-transcription and polymerase chain reaction (RT/PCR) amplification of its fusion transcripts, which can be quantified by competitive PCR and similar assays for assessment of residual disease in the follow-up of therapy. In the great majority of CML patients the BCR-ABL transcripts exhibit a b2a2 and/or a b3a2 junction; in rare cases, the only detectable BCR-ABL transcripts have unusual junctions, such as b2a3, b3a3, e1a2 or e6a2. There is a recent suggestion that the BCR-ABL gene may not be always 'functional', since extremely low levels of BCR-ABL transcripts can be found in leucocytes from normal individuals and, conversely, it appears that no BCR-ABL transcription can be detected in a proportion of Ph-positive haematopoietic progenitors from some CML patients. The role, if any, of the reciprocal ABL-BCR hybrid gene in CML is unknown. Although its mRNA message is in frame, no ABL-BCR fusion protein has yet been identified in CML patients. The blast crisis of CML has been variably associated with abnormalities of proto-oncogenes, such as RAS and MYC, or of tumour suppressor genes, in particular RB, p53 and p16, or with the generation of chimeric transcription factors, as in the AML1-EVI1 gene fusion. It is likely, therefore, that multiple and alternative molecular defects, as opposed to a single universal mechanism, underlie the acute transformation of the disease.

Ex Output:

Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?


