Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Our clothes are a powerful tool that can make us feel better about ourselves. One way in which this works is by wearing different color1s of clothes. Normally when we are sad, we will wear dark color1ed clothes. Oppositely, when we are happy, we often choose to wear brightly color1ed clothes. The reason for this is that our choice of color1 mirrors is how we are feeling. Those who don't believe in the idea are often heard saying, "if only this truly worked". Well in reply to those people, there has been a lot of research into what happens to someone's feelings when they are asked to wear just one color1 of clothes. It has been proven that if we wear particular color1s of clothes they can change our feelings. Suppose we are feeling sad, if we wear black we may begin to feel worse. However, if we wear green, red or yellow, we may begin to feel better. Each color1 is said to have its own healing power. So remember, if you are not feeling your best, you can always try out some different color1ed clothes. If one color1 has no effect on your feelings, maybe another will.

A: What's the author's attitude toward "wearing particular color1s of clothes can change our feelings"?
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Q: CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 different mutations in the NOTCH3 gene have been reported in CADASIL patients, of which 95% are missense point mutations. Many polymorphisms have also been identified in the NOTCH3 coding sequence, some of them leading to amino acid substitutions. The aim of the present study was to analyze the NOTCH3 gene in a large group of patients affected by leukoencephalopathy and to investigate the presence of genetic variants. The molecular analysis revealed several nucleotide alterations. In particular, we identified 20 different mutations, 22 polymorphisms, and 8 genetic variants of unknown pathological significance never reported previously. We hope that this NOTCH3 gene mutational analysis, performed in such a significant number of unrelated and related patients affected by leukoencephalopathy, will help in molecular screening for the NOTCH3 gene, thus contributing to enlargement of the NOTCH3 gene variation database.

A: Which amino acid residue appears mutated in most of the cases reported with  cadasil syndrome?
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Q: It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -"if 70% of water is used for agriculture then that's what we should target" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal.

A:
What is the main idea of this passage?
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