Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: It has been reported that the R497K polymorphism of the epidermal growth factor receptor (EGFR) gene has attenuated functions in ligand binding, tyrosine kinase activation, and growth stimulation. On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib. We investigated the EGFR mutations and/or R497K polymorphism statuses in 225 surgically treated NSCLC cases. 192 adenocarcinoma cases were included. The presence or absence of EGFR polymorphism of exon 13 was analyzed by PCR-RFLP method. EGFR mutations at kinase domain were found from 95 of 225 lung cancer patients. In 86.2% of patients, homo- or heterozygous Lys497 allele was present. No correlation existed between R497K EGFR genotype and clinico-pathological features, such as gender, smoking status, and pathological subtypes. EGFR mutation status was not correlated with R497KEGFR genotype of lung cancers. In node-negative patients, R497KEGFR genotype was not correlated with disease outcome. In node-positive patients, however, R497K EGFR was significantly associated with better overall survival. This association was attributable to neo-adjuvant or adjuvant chemotherapy. In 46 total gefitinib treated NSCLC patients, the prognosis was not different between the EGFR wild type (GG) patients and AG+AA patients. R497KEGFR polymorphism might be associated with favorable prognosis of advanced lung cancers and correlated with chemosensitivity.

Answer: Mutations in which gene determine response to both erlotinib and gefitinib?


Question: After winning in a close game at home, the Steelers traveled to Cincinnati for Game 2 against the Bengals. The Bengals scored first in the first quarter when Randy Bullock kicked a 35-yard field goal to make it 3-0. They would then make it 10-0 when Andy Dalton found A.J. Green on an 8-yard pass. In the second quarter, Dalton and Green connected again on a 15-yard pass to make it 17-0. The Steelers managed to get on the board before halftime when Chris Boswell put a 30-yard field goal through to make the score 17-3. In the third quarter, the Steelers drew closer when Ben Roethlisberger found Le'Veon Bell on a 35-yard touchdown to make it 17-10. The Bengals moved back ahead by double digits when Randy Bullock kicked a 31-yard field goal to make it 20-10. In the fourth quarter, it was all Steelers when Boswell put up a 37-yard field goal to make it 20-13. Roethlisberger then found Antonio Brown on a 6-yard pass to tie the game up at 20-20. Finally, Boswell was able to seal the victory with a 38-yard field goal to make the final score 23-20. With their sixth straight win over the Bengals, the Steelers improved to 10-2. The victory marks the third time that the Steelers have recorded two different 7+ win streaks within consecutive and separate regular seasons (1975-76, 1994-95). The team also won their 8th straight game against a divisional opponent. With the win, the Steelers began 4-0 in their division for the first time since 2008. The 17-point comeback was the Steelers' largest since they came back from down 17 on December 20, 2015 against the Denver Broncos, and their largest on the road since their 21-point comeback on October 5, 1997 against the Baltimore Ravens.

Answer: Which player kicked the second-longest field goal?


Question: Pasta is the world's favorite food. Asurveytaken in 17 countriesconfirmedthat pasta is what people like to eat most. Not only is pasta the number one food in its home country -Italy, but is alsoenjoyedin faraway places like the Philippines, Mexico andSouth Africa. Pasta has become popular, for one thing, because it is cheap and easy to prepare. Just cook noodles or other forms of pasta, make a sauce to go with it and you're finished. Many different types of meals can becreatedwith pasta. It tastes good and fills your stomach. It produces energy in the form ofcarbohydrates , which is whyathleteseat pasta regularly. Pasta can also be kept for a longer time. You don't have to use it up at once. Pasta has also become popular because it stands for the Italian way of life. People all over the world like it because it's so simple. It has two basic ingredients , wheatand water, just like bread. Legend has itthat Marco Polo brought pasta back to Italy with him but this is not true. Arabs probably brought a noodle-likedishtoSicilyin the 8th century. Farmers have been growing wheat, the mainingredientof pasta, there for ages. The worldwide sales of pasta have risen sharply over the past decade. Italy leads the pasta-eatingcommunityof the world. The Italians are the number one consumers followed by Venezuela and Tunisia.

Answer:
In which country do people eat pasta most?


