Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.

Ex Output:
Which is the receptor for substrates of Chaperone Mediated Autophagy?


Ex Input:
Saturday, October 8, 120 miles northeast of Blainsworth, Nebraska; 1:16 p.m.Bob Irisin, a metrologist for the Kansas City weather bureau, is riding in his Bronco truck when he stops and radios to his friend Stan in Kansas City, that he is witnessing a sudden change in weather patterns in the area. Then a tornado suddenly touches down near a farm where Bob sees a family of a man, woman and their little girl standing in front of the house, unaware of the tornado approaching behind them. Bob drives as near as he can go and manages to yell out a warning to the family seconds before they see the twister coming. The family runs into their storm shelter just in time before the twister destroys their house. Bob drives away from harms way just in time.Meanwhile, in Blainsworth, there is the annual fall Bike-a-thon race for the high school kids. 13-year-old Dan Hatch gets a flat tire and doesnt come in at all. Dans stern father, Jack, is arguing with a banker who's asking to foreclose on his hardware shop since a new mall has opened in the nearby town. Jack refuses to sell the shop at any price. Dan walks his bike into the town square where his best friend, Arthur, talks with him about getting "crashed and burned" during the race. Jack walks over and becomes hard on Dan for not finishing the race like a man should. Dan yells at his father for being so demanding and that he can't expect anything from anyone. Dan's mother, Laura, with her new baby Ryan and her friend Jenny, walk by and never less tell him he did okay anyway. Just then, Dan is called to the square podium for he is has been chosen by a lottery to be the winner of a new Schwinn Voyager bicycle, much to his father and mother's delight.75 miles northeast of Blainsworth; 3:37 p.m. Bob sits in his Bronco truck and radios in of rogue weather patterns, while observing another tornado rip through a nearby trailer park. Bob tells Stan that the front is moving south instead of north and the atmospheric activity is the most bizarre he has ever seen. Bob decides to travel to Blainsworth to see if anything will happen.Outside of Blainsworth, Dan and Arthur sit in the woods looking up at the clear sky. Dan tell Arthur about his fathers demanding which is a driving force that he cant stand. Then Arthur's two younger sisters, Stacey and Ronnie Vae, appear and want Arthur to come home since their parents are out of town for the weekend. Arthur and Dan watch as clouds begin to roll in and they decide to get indoors. At Arthurs house, the boys play a game of pool, in which Dan forgets he's suppose to take his grandmother's dog for a walk.Six miles northeast of Blainsworth 4:30 p.m.; Dan arrives at his grandmother Goldie's house where his father is already there taking her dog to the vet, for it has a bad leg. Jack yells at Dan for not being responsible for anything, and Dan rides on his new bike home.Arthur arrives at the Hatch house, were Laura is getting ready to leave for work for the evening. Jenny arrives at the house to pick Laura up, were they talk about Jack being so domineering on Dan for he doesn't want Dan to end up a loser like him.Nightfall. Arthur and Dan play with musical instruments, while checking every few minutes if baby Ryan in the next room is all right. Jack then arrives and tells Dan and Arthur to bring their bicycles in for its raining. Going out, they find that its raining hard and the winds are picking up speed. Arthur tells Dan that since hes originally from Los Angeles, he enjoys the rain, while Dan sees little amusement in it, for he tells Arthur that rain and hailstorms can get bad.At the local diner in town, Laura is waitressing when Bob walks in asking for some coffee. Bob overhears a farmer named Gus talk about the storm and of tornados reported in the area. Bob tells Gus that most people killed by tornados

Ex Output:
What kind of race does Jack push Danny to compete in?


Ex Input:
One man tells of driving on a long and lonely road, the last 65 miles of it unpaved, in order to watch Indian dances in the state of Arizona.After the dances, he returned to his car only to find that it had a flat tire.He put on the spare and drove to the only service station in that town. "Do you fix flats?" he inquired of the attendant. "Yes," came the answer. "How much do you charge?" he asked. With a twinkle in his eye, the man replied, "What difference does it make?" This is what has been called a "Hobson's choice".A Hobson's choice is a situation that forces a person to accept whatever is offered or go without. According to Barbara Berliner, the phrase was inspired by sixteenth-century entrepreneur Thomas Hobson.There was no choice by the customer -- it was strictly Hobson's choice. But often we really have a choice, and the choice does make a difference.We may not always believe it.We may feel as if we have no choice, but almost always there is a choice in the matter.And when we realize that we do most things by choice, then we are taking control of our own lives. Someone challenged me to try an experiment that completely changed my perspective(,)."For the next seven days," he said, "remove the words 'I have to' from your vocabulary and say 'I choose to'.Don't say, 'I have to work late tonight'.Instead, say, 'I choose to work late'.When you choose to do it, you take control of your life.Instead of saying 'I have to stay home', try 'I choose to stay home'.The way you spend your time is your choice.You are responsible.You have control." In just seven days I was no longer saying "I have to" and I felt better about my decisions.I learned that there is very little in my life I actually have to do.You and I decide to do certain things because we believe that it will be for the best.When we remove "I have to" from our vocabularies, we take control. Try it for a week and you see what happens.I think you'll see it's a change for the better.

Ex Output:

What's the best title of this passage?


