TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensory-motor neurological disorder with a circadian component. RLS is characterized by uncomfortable sensations in the extremities, generally at night or during sleep, which often leads to an uncontrollable urge to move them for relief. Recently, genomic studies identified single-nucleotide polymorphisms in BTBD9, along with three other genes, as being associated with a higher risk of RLS. Little is known about the function of BTBD9 or its potential role in the pathophysiology of RLS. We therefore examined a line of Btbd9 mutant mice we recently generated for phenotypes similar to symptoms found in RLS patients. We observed that the Btbd9 mutant mice had motor restlessness, sensory alterations likely limited to the rest phase, and decreased sleep and increased wake times during the rest phase. Additionally, the Btbd9 mutant mice had altered serum iron levels and monoamine neurotransmitter systems. Furthermore, the sensory alterations in the Btbd9 mutant mice were relieved using ropinirole, a dopaminergic agonist widely used for RLS treatment. These results, taken together, suggest that the Btbd9 mutant mice model several characteristics similar to RLS and would therefore be the first genotypic mouse model of RLS. Furthermore, our data provide further evidence that BTBD9 is involved in RLS, and future studies of the Btbd9 mutant mice will help shine light on its role in the pathophysiology of RLS. Finally, our data argue for the utility of Btbd9 mutant mice to discover and screen novel therapeutics for RLS.

SOLUTION: Willis-Ekbom disease is also known as?

PROBLEM: In the mid 1900s, people were startled to see the Cuyahoga River in Cleveland, Ohio, burst into flames! The river was so polluted with oil and other industrial wastes that it was flammable. Nothing could live in it. You can see the Cuyahoga River in Figure 21.16 Disasters such as rivers burning led to new U.S. laws to protect the water. For example, the Environmental Protection Agency (EPA) was established, and the Clean Water Act was passed. Now, water is routinely tested. Pollution is tracked to its source, and polluters are forced to fix the problem and clean up the pollution. They are also fined. These consequences have led industries, agriculture, and communities to pollute the water much less than before. Most water pollution comes from industry, agriculture, and municipal sources. Homes are part of the municipal source and the individuals and families that live in them can pollute the water supply. What can you do to reduce water pollution? Read the tips below. Properly dispose of motor oil and household chemicals. Never pour them down the drain. Also, dont let them spill on the ground. This keeps them out of storm sewers and bodies of water. Use fewer lawn and garden chemicals. Use natural products instead. For example, use compost instead of fertilizer. Or grow plants that can thrive on their own without any extra help. Repair engine oil leaks right away. A steady drip of oil from an engine can quickly add up to gallons. When the oil washes off driveways and streets it can end up in storm drains and pollute the water supply. Dont let pet litter or pet wastes get into the water supply (see Figure 21.17). The nitrogen they contain can cause overgrowth of algae. The wastes may also contain bacteria and other causes of disease. Water treatment is a series of processes that remove unwanted substances from water. The goal of water treatment is to make the water safe to return to the natural environment or to the human water supply. Treating water for other purposes may not include all the same steps. Thats because water used in agriculture or industry may not have to be as clean as drinking water. You can see how water for drinking is treated in Figure 21.18. Treating drinking water requires at least four processes: 1. Chemicals are added to untreated water. They cause solids in the water to clump together. This is called coagulation. 2. The water is moved to tanks. The clumped solids sink to the bottom of the water. This is called sedimentation. 3. The water is passed through filters that remove smaller particles from the water. This is called filtration. 4. Chlorine is added to the water to kill bacteria and other microbes. This is called disinfection. Finally, the water is pure enough to drink. Conserving water means using less of it. Of course, this mostly applies to people in the wealthy nations that have the most water and also waste the most. Irrigation is the single biggest use of water. Overhead irrigation wastes a lot of water. Drip irrigation wastes a lot less. Figure 21.19 shows a drip irrigation system. Water pipes run over the surface of the ground. Tiny holes in the pipes are placed close to each plant. Water slowly drips out of the holes and soaks into the soil around the plants. Very little of the water evaporates or runs off the ground. Some communities save water with rationing. Much rationing takes place only during times of drought. During rationing, water may not be used for certain things. For example, communities may ban lawn watering and car washing. People may be fined if they use water in these ways. You can do your part. Follow any bans where you live. Its easy to save water at home. If you save even a few gallons a day you can make a big difference over the long run. The best place to start saving water is in the bathroom. Toilet flushing is the single biggest use of water in the home. Showers and baths are the next biggest use. Follow the tips below to save water at home. Install

SOLUTION: process in water treatment in which small particles are separated from water

PROBLEM: Selenoproteins are proteins containing an uncommon amino acid selenocysteine (Sec). Sec is inserted by a specific translational machinery that recognizes a stem-loop structure, the SECIS element, at the 3' UTR of selenoprotein genes and recodes a UGA codon within the coding sequence. As UGA is normally a translational stop signal, selenoproteins are generally misannotated and designated tools have to be developed for this class of proteins. Here, we present two new computational methods for selenoprotein identification and analysis, which we provide publicly through the web servers at [Link] or [Link] SECISearch3 replaces its predecessor SECISearch as a tool for prediction of eukaryotic SECIS elements. Seblastian is a new method for selenoprotein gene detection that uses SECISearch3 and then predicts selenoprotein sequences encoded upstream of SECIS elements. Seblastian is able to both identify known selenoproteins and predict new selenoproteins. By applying these tools to diverse eukaryotic genomes, we provide a ranked list of newly predicted selenoproteins together with their annotated cysteine-containing homologues. An analysis of a representative candidate belonging to the AhpC family shows how the use of Sec in this protein evolved in bacterial and eukaryotic lineages.

SOLUTION:
What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?

