Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in adults. Classical ALS is characterized by the death of upper and lower motor neurons leading to progressive paralysis. Approximately 10% of ALS patients have familial form of the disease. Numerous different gene mutations have been found in familial cases of ALS, such as mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), C9ORF72, ubiquilin-2 (UBQLN2), optineurin (OPTN) and others. Multiple animal models were generated to mimic the disease and to test future treatments. However, no animal model fully replicates the spectrum of phenotypes in the human disease and it is difficult to assess how a therapeutic effect in disease models can predict efficacy in humans. Importantly, the genetic and phenotypic heterogeneity of ALS leads to a variety of responses to similar treatment regimens. From this has emerged the concept of personalized medicine (PM), which is a medical scheme that combines study of genetic, environmental and clinical diagnostic testing, including biomarkers, to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and similarities between animal models of disease and human disease. Finally, we reviewed application of biomarkers and gene therapies relevant in personalized medicine approach. For instance, this includes viral delivering of antisense oligonucleotide and small interfering RNA in SOD1, TDP-43 and C9orf72 mice models. Promising gene therapies raised possibilities for treating differently the major mutations in familial ALS cases.
Example Output: Which human disease is associated with mutated UBQLN2

Example Input: Elis Stromgren's son was the astronomer Bengt Stromgren, who succeeded his father in Copenhagen in 1940.
Example Output: Who is the offspring of Elis Strömgren?

Example Input: A small amount of geologic activity, known as intraplate activity, does not take place at plate boundaries but within a plate instead. Mantle plumes are pipes of hot rock that rise through the mantle. The release of pressure causes melting near the surface to form a hotspot. Eruptions at the hotspot create a volcano. Hotspot volcanoes are found in a line (Figure 1.1). Can you figure out why? Hint: The youngest volcano sits above the hotspot and volcanoes become older with distance from the hotspot. The first photo above is of a volcanic eruption in Hawaii. Hawaii is not in western North America, but is in the central Pacific ocean, near the middle of the Pacific Plate. The Hawaiian Islands are a beautiful example of a hotspot chain in the Pacific Ocean. Kilauea volcano lies above the Hawaiian hotspot. Mauna Loa volcano is older than Kilauea and is still erupting, but at a slower rate. The islands get progressively older to the northwest because they are further from the hotspot. This is because the Pacific Plate is moving toward the northwest over the hotspot. Loihi, the youngest volcano, is still below the sea surface. Since many hotspots are stationary in the mantle, geologists can use some hotspot chains to tell the direction and the speed a plate is moving (Figure 1.2). The Hawaiian chain continues into the Emperor Seamounts. The bend in the chain was caused by a change in the direction of the Pacific Plate 43 million years ago. Using the age and distance of the bend, geologists can figure out the speed of the Pacific Plate over the hotspot. The Hawaiian Islands have formed from volcanic eruptions above the Hawaii hotspot. The second photo in the introduction is of a geyser at Yellowstone National Park in Wyoming. Yellowstone is in the western U.S. but is inland from the plate boundaries offshore. Hotspot magmas rarely penetrate through thick continental crust, so hotspot activity on continents is rare. One exception is the Yellowstone hotspot (Figure 1.3). Volcanic activity above the Yellowstone hotspot on can be traced from 15 million years ago to its present location on the North American Plate. The ages of volcanic activity attributed to the Yellowstone hotspot. Click image to the left or use the URL below. URL:
Example Output:
geologic activity that takes place away from the plate boundary.

