Given a paragraph, your job is to generate a question that can be answered from the passage. The answer to your question should be a single entity, person, time, etc. that can be extracted from the passage.

Q: Chloroplasts have their own DNA, often abbreviated as ctDNA, or cpDNA. It is also known as the plastome. Its existence was first proved in 1962, and first sequenced in 1986—when two Japanese research teams sequenced the chloroplast DNA of liverwort and tobacco. Since then, hundreds of chloroplast DNAs from various species have been sequenced, but they're mostly those of land plants and green algae—glaucophytes, red algae, and other algal groups are extremely underrepresented, potentially introducing some bias in views of 'typical' chloroplast DNA structure and content.

A: What is chloroplast DNA abbreviated as?
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Q: 'The Islamic State', formerly known as the 'Islamic State of Iraq and the Levant' and before that as the 'Islamic State of Iraq', (and called the acronym Daesh by its many detractors), is a Wahhabi/Salafi jihadist extremist militant group which is led by and mainly composed of Sunni Arabs from Iraq and Syria. In 2014, the group proclaimed itself a caliphate, with religious, political and military authority over all Muslims worldwide. As of March 2015[update], it had control over territory occupied by ten million people in Iraq and Syria, and has nominal control over small areas of Libya, Nigeria and Afghanistan. (While a self-described state, it lacks international recognition.) The group also operates or has affiliates in other parts of the world, including North Africa and South Asia.

A: What type of group is The Islamic State?
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Q: In contrast, during wake periods differentiated effector cells, such as cytotoxic natural killer cells and CTLs (cytotoxic T lymphocytes), peak in order to elicit an effective response against any intruding pathogens. As well during awake active times, anti-inflammatory molecules, such as cortisol and catecholamines, peak. There are two theories as to why the pro-inflammatory state is reserved for sleep time. First, inflammation would cause serious cognitive and physical impairments if it were to occur during wake times. Second, inflammation may occur during sleep times due to the presence of melatonin. Inflammation causes a great deal of oxidative stress and the presence of melatonin during sleep times could actively counteract free radical production during this time.

A:
What are examples of differentiated effector cells that peak during wake periods?
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