In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: In contrast to the bacterial ones, the eukaryotic chromosomes need multiple origins of replication because: 
 Options:  <1> They can not be replicated bidirectionally. <2> They are not usually circular. <3> The processivity of eukaryotic DNA polymerase is much lower than that of bacterial DNA polymerase. <4> Its replication rate is much slower, and they would need too much time using a single source. <5> They have several DNA polymerases for different purposes, and they need the corresponding variety of origins.
4