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Ben Jones gave Wales a 13-0 lead with a try, conversion and penalty early on but Harry Randall took a superb kick-and-go to cross and claw England back.
Max Wright got England's second try to put them ahead before Will Butler extended the lead at the break.
Chris Coleman crossed to set up a tense finale but Zach Mercer sealed it.
The result was England's second bonus-point win in the competition, after they beat France in their opening match.
Meanwhile, Wales slipped to defeat at home a week after they beat Italy U20s 27-5.
Wales had won their last eight matches in the Under-20s Six Nations, while England now extend their winning streak to seven games in all competitions.
Jones put Wales into a commanding lead early on as he scored all of their 13 points prior to England's breakthrough.
Randall touched down before half-time as the visitors began to take control, but Coleman's try gave Wales hope of recording a comeback.
Man of the match Mercer, however, powered over at the other end soon after to make sure of victory for England.
Wales U20 team: Will Talbot-Davies (Newport Gwent Dragons); Jared Rosser (Newport Gwent Dragons), Ioan Nicholas (Scarlets), Keiran Williams (Ospreys), Ryan Conbeer (Scarlets), Ben Jones (Cardiff Blues), Dane Blacker (Cardiff Blues); Rhys Carre (Cardiff Blues), Ellis Shipp (Newport Gwent Dragons), Keiron Assiratti (Cardiff Blues), Callum Bradbury (Cardiff Blues), Sean Moore (Pontypridd), Morgan Sieniawski (Cardiff Blues), Will Jones (c) (Ospreys), Morgan Morris (Hartpury)
Replacements: Corrie Tarrant (Cardiff Blues), Steff Thomas (Scarlets) Chris Coleman (Newport Gwent Dragons), Alex Dombrandt (Cardiff Met), Aled Ward (Cardiff Blues), Declan Smith (Scarlets), Phil Jones (Ospreys), Cameron Lewis (Cardiff Blues)
England U20 team: Tom Parton; Joe Cokanasiga, Max Wright, Will Butler, Gabriel Ibitoye, Jacob Umaga, Harry Randall, Zach Mercer, Ben Earl, Tom Curry, Justin Clegg, Nick Isiekwe, Joseph Morris, Joe Mullis, Ollie Dawe
Replacements: Curtis Langdon, Alex Seville, Ciaran Knight, Josh Caulfield, Josh Bayliss, Alex Mitchell, 22. James Grayson, Dominic Morris
England Under-20s ended Wales Under-20s' hopes of recording a second successive Six Nations Grand Slam with a bonus-point win in Colwyn Bay.