Given a scientific passage and an answer, generate a question for the given answer.

Example input: Passage: A frameshift mutation is a deletion or insertion of one or more nucleotides that changes the reading frame of the base sequence. Deletions remove nucleotides, and insertions add nucleotides. Consider the following sequence of bases in RNA:. Answer: nucleotides.
Example output: A frameshift mutation is a deletion or insertion of one or more of what that changes the reading frame of the base sequence?
Example explanation: The science passage defines frame mutation and the main compoment here is nucleotides. Hence the generated question is apt.
Q: Passage: Chemical reactions always involve energy. Energy is a property of matter that is defined as the ability to do work. When methane burns, for example, it releases energy in the form of heat and light. Other chemical reactions absorb energy rather than release it. Answer: energy
A:
Chemical reactions always involve what?