Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
One example is below.
Q: In 1582 the united provinces invited francis, duke of anjou to lead them; but after a failed attempt to take antwerp in 1583, the duke left the netherlands again. after the assassination of william of orange (10 july 1584), both henry iii of france and elizabeth i of england declined the offer of sovereignty. however, the latter agreed to turn the united provinces into a protectorate of england (treaty of nonsuch, 1585), and sent the earl of leicester as governor-general. this was unsuccessful and in 1588 the provinces became a confederacy. the union of utrecht is regarded as the foundation of the republic of the seven united provinces, which was not recognized by the spanish empire until the peace of westphalia in 1648.
A: In what year did francis, duke of anjou leave the netherlands?
Rationale: The generated question is perfect. Because the question is based on second sentence of the input passage and its answer is 1583.
Q: To investigate the use of tanezumab, a humanized monoclonal antibody that inhibits nerve growth factor, for the treatment of moderate to severe osteoarthritis in Japanese patients. Patients received tanezumab 10, 25, 50, 100, 200g/kg, or placebo and were followed for 92 or 120 days. Endpoints included the incidence of adverse events (AEs) and the change from baseline to week 8 in pain intensity and the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) subscales. Patients (n=83) were 69% female, age 44-73 years, with a Kellgren-Lawrence X-ray grade of 2-4. At week 8, compared with placebo, tanezumab 25, 100, and 200g/kg improved index knee pain during walking (-18.5,-14.3, and-27.6, respectively), index knee pain in the past 24h (-19.1,-14.6, and-24.2, respectively), current index knee pain (-16.5,-10.9, and-22.8, respectively), and the WOMAC pain (-11.5,-9.6, and-18.8, respectively), physical function (-8.7,-9.5, and-17.6, respectively), and stiffness (-20.4,-11.2, and-10.2, respectively) subscales. Overall, seven patients reported AEs of abnormal peripheral sensation: allodynia (two in the tanezumab 200g/kg group); paresthesia (two in the tanezumab 200g/kg group), dysesthesia (one in the tanezumab 200g/kg group); thermohypoesthesia (one in the tanezumab 100g/kg group), and decreased vibratory sense (one in the placebo group). All of these AEs were mild to moderate in severity and transient in nature. Tanezumab was safe and generally well tolerated and may improve pain symptoms in Japanese patients with moderate to severe osteoarthritis of the knee. CLINICALTRIALS.GOV IDENTIFIER: NCT00669409.
A:
What is the target of tanezumab?