You are given a sentence and your task is to generate another sentence that supports the given input.

Example input: In spite of this reduced heat input, the surface temperature of Venus is higher than that of the Earth.
Example output: Venus has a warmer average surface temperature than earth.
Example explanation: Output statement supports the input statement's claim about the temperatures of Venus being higher than the earth.
Q: The significance of these changes lies in the demonstration that they were associated with the release of calcium ion, which as a 'second messenger', was proposed in turn to activate systems that direct development of the early stages of the parasite (94).
A:
Calcium ion is an example of a second messenger.