Definition: In this task, you are given a sentence in the English language. Your job is to translate the English sentence into the Spanish language.
Input: Rolitetracycline is a prodrug of tetracycline of Mannich base nature, how does the activation of this prodrug take place ?
Output:
La rolitetraciclina es un profármaco de la tetraciclina de naturaleza de base de Mannich, ¿cómo tiene lugar la activación de este profármaco?