Q: In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Question: Question linked to image # 16 Which of the following will support the diagnosis of the underlying disease? 
 Options:  <1> Cutaneous biopsy. <2> Microangiography <3> Determination of cryoglobulins. <4> Serum tryptase. <5> JAK 2 mutation study.
A:
5