Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Example Input: Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.
Example Output: adverse drug event

Example Input: Amphotericin B nephrotoxicity in humans decreased by salt repletion.
Example Output: adverse drug event

Example Input: CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.
Example Output:
adverse drug event

