Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Input: Consider Input: Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.

Output: adverse drug event


Input: Consider Input: When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.

Output: adverse drug event


Input: Consider Input: Liver biopsy disclosed submassive hepatic necrosis.


Output: non-adverse drug event


