In a 91 days oral repeated dose toxicity study mice were administered 355trimethyl2cyclohexen1one via gavage at the doses 0 625 125 250 500 and 1000 mgkg bwday for 5 daysweek Effects were only observed as mortality at the highest dose and dosis related decrease in body weight in males at 250 mgkg bwday and above NOAEL is set to 125 mgkg bwday IUCLID 2000

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In a 91 days oral repeated dose toxicity study, mice were administered 3,5,5-trimethyl-2-cyclohexen-1-one via gavage at the doses 0, 62.5, 125, 250, 500 and 1000 mg/kg bw/day for 5 days/week. Effects were only observed as mortality at the highest dose and dosis related decrease in body weight in males at 250 mg/kg bw/day and above. NOAEL is set to 125 mg/kg bw/day (IUCLID 2000).