Given the task definition and input, reply with output. In this task, you will be given sentences in which your task is to recognize the name of the drug or medicine. Drugs are substances that change a person's mental or physical state. They can affect how your brain works, how you feel and behave, your understanding, and your senses. Although there might be several correct answers, you need to write one of them.

Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.

Methotrexate