Given the task definition, example input & output, solve the new input case.
Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
Example: A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.
Output: adverse drug event
Here, the child is facing some trouble after undergoing a particular therapy, thereby causing an adverse effect of the therapy.

New input case for you: However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.
Output:
adverse drug event