Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: Change in gene expression associated with pancreatic cancer could be attributed to the variation in histone posttranslational modifications leading to subsequent remodeling of the chromatin template during transcription. However, the interconnected network of molecules involved in regulating such processes remains elusive. hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic potential. Our study explores the possibility that regulation of histone methylation by hPaf1 can contribute towards alteration in gene expression by nucleosomal rearrangement. Here, we show that knockdown of hPaf1/PD2 leads to decreased di- and tri-methylation at histone H3 lysine 4 residues in pancreatic cancer cells. Interestingly, hPaf1/PD2 colocalizes with MLL1 (Mixed Lineage Leukemia 1), a histone methyltransferase that methylates H3K4 residues. Also, a reduction in hPaf1 level resulted in reduced MLL1 expression and a corresponding decrease in the level of CHD1 (Chromohelicase DNA-binding protein 1), an ATPase dependent chromatin remodeling enzyme that specifically binds to H3K4 di and trimethyl marks. hPaf1/PD2 was also found to interact and colocalize with CHD1 in both cytoplasmic and nuclear extracts of pancreatic cancer cells. Further, reduced level of CHD1 localization in the nucleus in hPaf1/PD2 Knockdown cells could be rescued by ectopic expression of hPaf1/PD2. Micrococcal nuclease digestion showed an altered chromatin structure in hPaf1/PD2-KD cells. Overall, our results suggest that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells. 
 Question: Which is the histone residue methylated by MLL1?

Answer: h3k4


Question: Context: Leonard (Phoenix) is walking along a bridge over a creek in Brooklyn, when suddenly he jumps into the water in an attempted suicide. He changes his mind and quickly walks home to his parents' apartment. His mother, seeing him dripping wet, tells her husband their son has tried it again and it becomes evident that Leonard has tried to kill himself before. His parents tell him that a potential business partner and his family are invited for dinner that night and ask him to be present. When they arrive, Leonard finds that he had been set up with the other family's daughter, Sandra (Shaw). She inquires about his interest in photography and notices a photo of a girl above his headboard. He explains he had been engaged to the girl for several years, but the relationship was broken off when it turned out both he and his fiancee carried the gene for TaySachs disease, which results in diseased children who generally don't live beyond age 12, so they would be unable to have healthy children. Leonard meets a new neighbor, Michelle (Paltrow), and is immediately attracted to her, choosing to ignore that she has a drug usage problem. He learns that she is dating a married partner in her law firm, Ronald (Koteas). At her request, Leonard agrees to meet Ronald and Michelle for dinner at a restaurant. The couple leave him later that evening, as they have plans to attend the Metropolitan Opera. Leonard returns home upset, but to his surprise, Sandra arrives, sent over by Leonard's parents. She is under the impression that Leonard wanted her to come by, but realizes by his surprised look, that she was set up. She apologizes for the misunderstanding and says that if he isn't interested, a lot of other guys are. Leonard says that he likes her, and they kiss and eventually make love, and with time, his relationship with Sandra deepens. Michelle calls Leonard and says she is sick. He takes her to the hospital, where she has a D&C for a miscarriage. She had not known she was pregnant and is even more upset that Ronald didn't respond to her calls. Leonard takes her home but Ronald arrives. Leonard hides while Ronald apologizes to Michelle for not having come to her aid. Michelle coldly asks Ronald to leave. She then asks Leonard to write something on her forearm with his finger while she falls asleep. Leonard writes "I love you". Two weeks later, Michelle meets Leonard on the roof of their building and tells him that she has broken up with Ronald and is going to San Francisco. Leonard tells her not to leave and professes his love for her. They have sex and plan to leave together the next day for San Francisco. On New Year's Eve, Leonard buys an engagement ring for Michelle. He is then summoned by Sandra's father and is offered a partnership in the family businesses, with the assumption that he is going to marry Sandra. Noticing the jeweler's gift bag Leonard is holding, the father assumes it is for Sandra; Leonard lies that it is. During his parents' New Year's Eve party, Leonard ducks out to the courtyard to meet Michelle. Michelle arrives ten minutes past departure time and tells Leonard that she isn't going to San Francisco, because Ronald, having learned Michelle is leaving him for California, decided to leave his wife and children for her. Distraught, Leonard breaks things off with her for good. Feeling desolate, Leonard heads to the beach, presumably intending to kill himself. When he drops a glove that Sandra had bought for him, he realizes that, in Sandra, he has found someone who loves him and with whom he can build a decent life. He picks up the glove and sees the boxed engagement ring lying on the sand, where he had thrown it from the boardwalk earlier. He returns to the party, where he gives Sandra the ring and embraces her in a prolonged hug. 
 Question: where Leonard meets Ronald and Michelle for dinner in this movie?

Answer: a restaurant


Question: Context: Three men, Red Pollard (Tobey Maguire), Charles S. Howard (Jeff Bridges), and Tom Smith (Chris Cooper) come together as the principal jockey, owner, and trainer of the championship horse Seabiscuit, rising from troubled times to achieve fame and success through their association with the horse. Red is the child of a Canadian family financially ruined by the Great Depression. In desperate need of money, the family leaves Red with a horse trainer. Red eventually becomes a jockey, but makes extra money through illegal boxing matches which left him blind in one eye. Howard is a clerk in a bicycle shop who gets asked by a passing motorist to repair his automobile, a technology which has recently been introduced. As a result, Howard becomes knowledgeable enough with automobiles to increase their performance and sell them as a dealer, eventually becoming the largest car dealer in California and one of the Bay Area's richest men. However, his son is killed in an automobile accident while driving the family car, which sends Howard into a bout of deep depression, which eventually results in his wife (Valerie Mahaffey) leaving him. On a trip to Mexico to obtain a divorce and to drown his sorrows, he meets Marcela Zabala (Elizabeth Banks). Marcela helps Howard overcome his depression, mainly through horse-riding. After marrying Marcela, Howard acquires a stable of horses and later has a chance encounter with the skilled and kindly horse trainer and drifter Smith. Howard hires Smith to manage his stables after Smith, who specializes in rehabilitating injured and abused horses, explains to Howard "You don't throw a whole life away just 'cause it's banged up a little bit". Smith convinces Howard to acquire the colt "Seabiscuit", who comes from noted lineage but had been deemed "incorrigible" by past handlers and was later broken and trained to lose against better horses. Smith is unable to find a jockey willing to deal with Seabiscuit's temperament, but after witnessing Red Pollard brawling with other stable boys, he sees in him a similar temperament to the feisty horse and decides to appoint him as Seabiscuit's jockey. Seabiscuit and Pollard become close and they begin to race. After overcoming early difficulties, such as a dismissive media and Pollard's anger issues and blind eye, Seabiscuit begins to earn considerable success and becomes an extremely popular underdog for the millions affected by the Great Depression. Inspired, Howard tries repeatedly to provoke a race with the mocking New York tycoon Samuel Riddle and his fearsome stallion "War Admiral", the top race horse in the country. Riddle eventually relents to a match race on his terms between War Admiral and Seabiscuit, but while the date approaches, Pollard is injured in a riding accident, fracturing his leg. When the doctor reports that he will be unable to ride again, Red suggests that Howard get an old friend, the successful jockey George Woolf (Gary Stevens) to be Seabiscuit's new rider. Red teaches Woolf about Seabiscuit's handling and mannerisms. At the match race, Seabiscuit upsets the heavy favorite, War Admiral, partly because of a secret that Pollard relates to Woolf, instructing him to hold him head to head with the other horse so he gets "a good look at the Admiral." Later on, Seabiscuit is racing at Santa Anita when he is injured and has to stop. Red helps him to recover and get fit enough to race again. The last race is again at the Santa Anita, and Red rides him this time after putting a special self-made brace on his own leg to keep it stable. Woolf is on a different horse. Seabiscuit drops to last place and trails the pack, but Woolf holds back to be alongside Red and let Seabiscuit "get a good look". After a short conversation, Seabiscuit surges and wins the race. Red says, "You know, everyone thinks that we found this broken down horse and fixed him, but we didn't. He fixed us. Every one of us. And I guess in a way, we kinda fixed each other, too." 
 Question: How does Red almost go blind in one eye?

Answer:
boxing


