Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

According to Apollodorus, Agenor was born in Memphis of Egypt to Poseidon and Libya and he had a twin brother named Belus.
What was the name of Agenor mother?

All rocks on Earth change, but these changes usually happen very slowly. Some changes happen below Earths surface. Some changes happen above ground. These changes are all part of the rock cycle. The rock cycle describes each of the main types of rocks, how they form and how they change. Figure 4.1 shows how the three main rock types are related to each other. The arrows within the circle show how one type of rock may change to rock of another type. For example, igneous rock may break down into small pieces of sediment and become sedimentary rock. Igneous rock may be buried within the Earth and become metamorphic rock. Igneous rock may also change back to molten material and re-cool into a new igneous rock. Rocks are made of minerals. The minerals may be so tiny that you can only see them with a microscope. The minerals may be really large. A rock may be made of only one type of mineral. More often rocks are made of a mixture of different minerals. Rocks are named for the combinations of minerals they are made of and the ways those minerals came together. Remember that different minerals form under different environmental conditions. So the minerals in a rock contain clues about the conditions in which the rock formed (Figure 4.2). Geologists group rocks based on how they were formed. The three main kinds of rocks are: 1. Igneous rocks form when magma cools below Earths surface or lava cools at the surface (Figure 4.3). 2. Sedimentary rocks form when sediments are compacted and cemented together (Figure 4.4). These sediments may be gravel, sand, silt or clay. Sedimentary rocks often have pieces of other rocks in them. Some sedimentary rocks form the solid minerals left behind after a liquid evaporates. 3. Metamorphic rocks form when an existing rock is changed by heat or pressure. The minerals in the rock change but do not melt (Figure 4.5). The rock experiences these changes within the Earth. Rocks can be changed from one type to another, and the rock cycle describes how this happens. Any type of rock can change and become a new type of rock. Magma can cool and crystallize. Existing rocks can be weathered and eroded to form sediments. Rock can change by heat or pressure deep in Earths crust. There are three main processes that can change rock: Cooling and forming crystals. Deep within the Earth, temperatures can get hot enough to melt rock. This molten material is called magma. As it cools, crystals grow, forming an igneous rock. The crystals will grow larger if the magma cools slowly, as it does if it remains deep within the Earth. If the magma cools quickly, the crystals will be very small. Weathering and erosion. Water, wind, ice, and even plants and animals all act to wear down rocks. Over time they can break larger rocks into smaller pieces called sediments. Moving water, wind, and glaciers then carry these pieces from one place to another. The sediments are eventually dropped, or deposited, somewhere. The sediments may then be compacted and cemented together. This forms a sedimentary rock. This whole process can take hundreds or thousands of years. Metamorphism. This long word means to change form. A rock undergoes metamorphism if it is exposed to extreme heat and pressure within the crust. With metamorphism, the rock does not melt all the way. The rock changes due to heat and pressure. A metamorphic rock may have a new mineral composition and/or texture. An interactive rock cycle diagram can be found here: The rock cycle really has no beginning or end. It just continues. The processes involved in the rock cycle take place over hundreds, thousands, or even millions of years. Even though for us rocks are solid and unchanging, they slowly change all the time.
The process in which sedimentary rocks form begins with

A mutation in the ubiquilin 2 gene (UBQLN2) was recently identified as a cause of X-linked amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and a major component of the inclusion bodies commonly found with a wide variety of ALS. ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system. However, the molecular properties of mutant UBQLN2 remain unclear. To gain insight into the pathogenesis of UBQLN2-linked ALS/FTD, we examined the biochemical and cellular characteristics of mutant UBQLN2 in vitro. UBQLN2 localized in Rab11-positive endosomal vesicles formed by the ALS-linked molecule optineurin (OPTN). These vesicles were ubiquitin- and p62-immunopositive and also co-localized with an initiator of the autophagic process, ULK1, after amino acid starvation. An ALS-linked mutation (E478G) in OPTN abolished vesicle formation. ALS-linked mutations in UBQLN2 additively enhanced UBQLN2 aggregation and formation of inclusion bodies, resulting in mislocation from OPTN vesicles. UBQLN2 was found to be a potent regulator of the levels of the FTD-linked secretory factor progranulin, possibly via the endosomal system, and ALS-linked mutations disturbed these functional consequences. This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. These data suggest a novel disease spectrum and provide new pathological insights into OPTN and UBQLN2, enhancing our understanding of the molecular basis of ALS/FTD.

Which human disease is associated with mutated UBQLN2

