The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active.
Newborns are particularly susceptible to infections caused by?
low virulence organisms like Staphylococcus and Pseudomonas


Input: Edmund Burke
Immediately after reading Price's sermon, Burke wrote a draft of what eventually became, Reflections on the Revolution in France. On 13 February 1790, a notice in the press said that shortly, Burke would publish a pamphlet on the Revolution and its British supporters, however he spent the year revising and expanding it. On 1 November he finally published the Reflections and it was an immediate best-seller. Priced at five shillings, it was more expensive than most political pamphlets, but by the end of 1790, it had gone through ten printings and sold approximately 17,500 copies. A French translation appeared on 29 November and on 30 November the translator, Pierre-Gaëton Dupont, wrote to Burke saying 2,500 copies had already been sold. The French translation ran to ten printings by June 1791.

Which of Burke's writings was inspired by Price's sermon?
Output: Reflections on the Revolution in France


Input: Article: Copyright infringement is the use of works protected by copyright law without permission, infringing certain exclusive rights granted to the copyright holder, such as the right to reproduce, distribute, display or perform the protected work, or to make derivative works. The copyright holder is typically the work's creator, or a publisher or other business to whom copyright has been assigned. Copyright holders routinely invoke legal and technological measures to prevent and penalize copyright infringement.

Now answer this question: How do creators of content protect their work from infringement?

Output: routinely invoke legal and technological measures


Article: Between 1963 and 1965, there was a "downtown boom" that led to the construction of more than 700 buildings in the city. In 1968, Virginia Commonwealth University was created by the merger of the Medical College of Virginia with the Richmond Professional Institute. In 1970, Richmond's borders expanded by an additional 27 square miles (70 km2) on the south. After several years of court cases in which Chesterfield County fought annexation, more than 47,000 people who once were Chesterfield County residents found themselves within the city's perimeters on January 1, 1970. In 1996, still-sore tensions arose amid controversy involved in placing a statue of African American Richmond native and tennis star Arthur Ashe to the famed series of statues of Confederate heroes of the Civil War on Monument Avenue. After several months of controversy, the bronze statue of Ashe was finally completed on Monument Avenue facing the opposite direction from the Confederate Heroes on July 10, 1996.

Question: What combined with the Richmond Professional Institute to form Virginia Commonwealth University?
Ans: Medical College of Virginia


Here is a question about this article: Electric instruments such as the electric guitar, the electric bass and the ondes Martenot appear occasionally in the classical music of the 20th and 21st centuries. Both classical and popular musicians have experimented in recent decades with electronic instruments such as the synthesizer, electric and digital techniques such as the use of sampled or computer-generated sounds, and instruments from other cultures such as the gamelan.
What is the answer to this question: What type of instrument is the gamelan?
****
So... electronic


Article: On November 6, 2006, Microsoft announced the Xbox Video Marketplace, an exclusive video store accessible through the console. Launched in the United States on November 22, 2006, the first anniversary of the Xbox 360's launch, the service allows users in the United States to download high-definition and standard-definition television shows and movies onto an Xbox 360 console for viewing. With the exception of short clips, content is not currently available for streaming, and must be downloaded. Movies are also available for rental. They expire in 14 days after download or at the end of the first 24 hours after the movie has begun playing, whichever comes first. Television episodes can be purchased to own, and are transferable to an unlimited number of consoles. Downloaded files use 5.1 surround audio and are encoded using VC-1 for video at 720p, with a bitrate of 6.8 Mbit/s. Television content is offered from MTV, VH1, Comedy Central, Turner Broadcasting, and CBS; and movie content is Warner Bros., Paramount, and Disney, along with other publishers.

Question: What was the name of the 360's video store service?
Ans:
Xbox Video Marketplace