instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Alpha-synuclein(-syn) is the main protein component of Lewy bodies (LBs), that together with nigrostriatal dopamine neuron loss constitute typical pathological hallmarks of Parkinson's disease (PD). Glutamate N-methyl-d-aspartate receptor (NMDAR) abnormalities, peculiarly involving NR2B-containing NMDAR, have been observed in the brain of PD patients and in several experimental models of the disease. Recent findings, indicating that -syn can modulate NMDAR trafficking and function, suggest that this protein may be a pivotal regulator of NMDAR activity. Prompted by these evidences, we used fluorescence immunocytochemistry, western blotting and ratiometric Ca(2+) measurements to investigate whether wild type (wt) or C-terminally truncated -syn can specifically modulate NR2B-containing NMDAR levels, subcellular trafficking and function. In addition, we evaluated whether the exposure of primary cortical neurons to increasing concentrations of rotenone could differentially regulate NR2B levels and cell viability in the presence or in the absence of -syn. Our results indicate that both wt and C-terminally truncated -syn negatively modulate NR2B-containing NMDAR levels, membrane translocation and function. Moreover, we found that absence of -syn abolishes the rotenone-dependent decrease of NR2B levels and reduces neuronal vulnerability in primary cortical neurons. These findings suggest that -syn can modulate neuronal resilience by regulating NR2B-containing NMDAR, whose specific alterations could connect -syn pathology to neuronal degeneration in PD. 
 Question: Which is the primary protein component of Lewy bodies?
answer:
αsyn


question:
Context: The 1688 Glorious Revolution replaced James II and VII with his Protestant daughter Mary II and her husband William III and II. Since neither Mary or her sister Anne had surviving children, the 1701 Act of Settlement ensured a Protestant successor by excluding Catholics from the English and Irish thrones, and that of Great Britain after the 1707 Act of Union. When Anne became the last Stuart monarch in 1702, her heir was the distantly related but Protestant Sophia of Hanover, not her Catholic half-brother James Francis Edward. Sophia died two months before Anne in August 1714; her son became George I and the pro-Hanoverian Whigs controlled government for the next 30 years. 
 Question: What happened first, 1701 Act of Settlement or 1707 Act of Union?
answer:
1701 act of settlement


question:
Context: In the county, the population was spread out with 23.5% under the age of 18, 7.8% from 18 to 24, 28.5% from 25 to 44, 25.9% from 45 to 64, and 14.2% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 93.8 males. For every 100 females age 18 and over, there were 90.5 males. 
 Question: How old was the majority of the population?
answer:

25 to 44


