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Five others were injured by the blaze in a rural area close to Mexicali, near the border with the US.
Some 45 elderly people lived at the nursing home, a non-governmental organisation employee told local media.
She said the facility, called "Beautiful Dawn", housed formerly homeless people.
The mayor of Mexicali, Jaime Diaz Ochoa, said 23 residents had been taken to a temporary city shelter.
He said the authorities were trying to determine the cause of the deadly blaze.
A fire that broke out early on Tuesday at a home for the elderly in north-western Mexico has killed at least 15 people.

His comments came as he spoke to MPs on the Treasury Committee.
UK rates have been held at 0.5% since March 2009. Most economists are not expecting the Bank to raise rates until mid-2016 at the earliest.
Mr Carney said that "even with limited and gradual rate increases it still will be a relatively low interest rate environment".
He remained vague on when a rate rise might be coming, and added:   "The question in my mind is when the appropriate time for interests to increase and that is strongly consistent with the strength of the domestic economy."
Mr Carney also said that he did not see any need for negative interest rates.
Meanwhile, he said the Bank was monitoring groups of households to find out what impact any rate hike would have.
Kirstin Forbes, an external member of the Bank of England's Monetary Policy Committee, who was also giving evidence at the same hearing, said that the next interest rate move would be upwards.
"Given the state of the UK economy, a solid recovery, I still believe certainly the next move in interest rates will be up, we will not require loosening," she said.
Mr Carney also said productivity was more likely to exceed than undershoot the Bank's latest forecasts, reducing the pressure on inflation.
Meanwhile, sterling fell after the Bank's chief economist Andy Haldane said he saw more downside risks to growth and inflation than had been indicated by the Bank's latest economic outlook.
He also reiterated his view that the Bank's next move might actually be a rate cut.
"I see the balance of risks around UK GDP growth and inflation as skewed materially to the downside, more so than embodied in the November 2015 Inflation Report," he told the Treasury Committee.
In late morning trade sterling fell by 0.03% against the US dollar, to $1.5120, and by 0.15% against the euro, to 1.4198 euros.
Bank of England governor Mark Carney has said that UK interest rates are likely to remain low "for some time".

About 10,000 strikers and 5,000 police officers clashed at the coking plant near Rotherham in June 1984.
Former miners' leader Arthur Scargill called for an inquiry on Wednesday.
Interim Chief Constable Dave Jones said the Hillsborough inquests highlighted the need to "explore the circumstances of such significant events".
He added it "brought into sharp focus" the importance of understanding and confronting the past.
What was the 'Battle of Orgreave'?
A redacted version of a report by the Independent Police Complaints Commission (IPCC) into police conduct at Orgreave was published last year.
On Wednesday The Yorkshire Post reported the redacted sections proved the same senior officers were involved in both the aftermath of Orgreave and Hillsborough.
The IPCC previously said it was considering whether there were any remaining legal issues preventing full publication of its report.
The Orgreave Truth and Justice Campaign (OTJC) group has called on Mr Jones to open up the force's archives on the clashes.
Secretary Barbara Jackson said it welcomed the "growing recognition of the need to resolve and investigate this piece of unfinished business and a running sore in former mining communities and beyond".
A Home Office spokesperson said: "The Home Secretary is considering a submission from OTJC on the need for an inquiry relating to events at Orgreave.
"She will set out the government's position in due course."
Thousands of picketers confronted huge lines of police outside the coke works at Orgreave.
Miners wanted to stop lorry loads of coke leaving for the steel works, as police attempted to hold them back.
In 2015, the police watchdog said the passage of time meant allegations of assault and misconduct at Orgreave "could not be pursued".
Mr Jones took temporary charge of the South Yorkshire force after David Crompton was suspended in the wake of the conclusion to the Hillsborough inquests.
Mr Crompton's initial replacement, deputy Dawn Copley, stood down after her appointment was criticised due to a misconduct investigation.
Mr Jones said: "The Hillsborough inquests have brought into sharp focus the need to understand and confront the past and give people the opportunity to explore the circumstances of such significant events.
"I would therefore welcome an appropriate independent assessment of Orgreave, accepting that the way in which this is delivered is a matter for the Home Secretary."
Lawyers for 22 families of the victims of the Hillsborough disaster said they would be asking Mr Jones whether he has invited an external team to carry out a "root and branch" investigation into the values of South Yorkshire Police, "including its conduct at Orgreave".

An independent review into the so-called Battle of Orgreave would be welcomed, South Yorkshire Police has said.

