See this dialog response. Additional findings show that the risk of frailty increases with the number of dysregulated physiological systems in a nonlinear pattern, independent of chronic diseases and chronologic age, suggesting synergistic effects of individual abnormalities that on their own may be relatively mild. What came before?
DIALOG:
Person A: What is the utility of the SHARE-FI?
Person B: The SHARE-FI has good clinical utility as it provides relatively quick assessment of frailty in often time-poor healthcare settings.
Person A: Are there any other interesting aspects about this article?
Person B: It has been suggested that the biological underpinnings of frailty are multifactorial, involving dysregulation across many physiological systems.
Person A: What kind of dysregulation?
Person B: A proinflammatory state, sarcopenia, anemia, relative deficiencies in anabolic hormones (androgens and growth hormone) and excess exposure to catabolic hormones (cortisol), insulin resistance, glucose levels, compromised altered immune function, micronutrient deficiencies and oxidative stress are each individually associated with a higher likelihood of frailty.
Person A: Are there any other interesting aspects about this article?
Person B: 