TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?

SOLUTION: nadph oxidase 1

PROBLEM: Context: Future Life Pets By DogTown Media, LLC Open iTunes to buy and download apps. *Price: $2.99 *Category: Lifestyle *Updated: Jan 07, 2012 *Version: 1.1 *Size: 36.3 MB *Language: English *Seller: DOG TOWN MEDIA *(c) DogTown Media LLC Description DISCOVER FUTURE LIFETIMES WITH YOUR PETS You can be transported into the future to be reunited with your pet in another place and time. As an internationally recognized psychic and best-selling author, Anne Jirsch will be your guide in this fascinating meditation game. Future Life Pets will take you into a state of deep relaxation to help you understand this special condition. With expert hypnosis you can discover how your paths will cross in your future lifetime. WHAT PEOPLE ARE SAYING "I immediately saw I was riding a tall black and white horse and you've guessed it --it was my dog and this time he was bigger than ever." --Mike from Kansas City. "Seeing both my cats in the future lifetime has given me so much joy. They are both cats again next time around, only a lot bigger and smoother. I clearly saw them both lie by my feet just as they do right now." --Felicity from Manchester, UK. The regular buyers of Anne's products include heads of industry, politicians, and celebrities of all kinds. She is a world famous psychic and author of three books Instant Intuition, The Future is Yours, and Cosmic Energy. More than a billion people in the world believe in the truth of meditation, through which we'll gain a greater understanding of our pets and ourselves. Prepare for the experience as the results are astonishing. 
 Question: If we want to use the app of Future Life Pets, what kind of language should we know?

SOLUTION: english

PROBLEM: Context: Coming off their bye week, the Jets stayed at home for a Week 10 duel with the Jacksonville Jaguars. New York would trail early in the first quarter with running back Maurice Jones-Drew's 33-yard touchdown run. The Jets would respond with kicker Jay Feely getting a 32-yard field goal, followed by rookie quarterback Mark Sanchez completing a 7-yard touchdown pass to wide receiver Jerricho Cotchery. In the second quarter, Jacksonville would take the lead as quarterback David Garrard got an 11-yard touchdown run and completed a 26-yard touchdown pass to wide receiver Mike Sims-Walker. New York would close out the half as Feely made a 37-yard field goal. After a scoreless third quarter, the Jets would regain the lead in the fourth quarter with a 40-yard field goal from Feely and a 1-yard touchdown run from running back Thomas Jones (with a failed 2-point conversion). However, the Jaguars got the last laugh as kicker Josh Scobee booted the game-winning 21-yard field goal. 
 Question: During which quarter was the longest field goal kick of the game?

SOLUTION:
second

