In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.

 In summary , whilst intensive investigations are in progress to target the many HIF - 1 effectors , the results herein indicate that blocking hypoxia - inducible pathways and enhancing NK - mediated antitumor immunity by targeting HIF - 1 itself may be advantageous , especially when combined with cancer immunotherapy .
HIF - 1