instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: In the era of the "sickest first" policy, patients with very high model for end-stage liver disease (MELD) scores have been increasingly admitted to the intensive care unit with the expectation that they will receive a liver transplant (LT) in the absence of improvement on supportive therapies. Such patients are often admitted in a context of acute-on-chronic liver failure with extrahepatic failures. Sequential assessment of scores or classification based on organ failures within the first days after admission help to stratify the risk of mortality in this population. Although the prognosis of severely ill cirrhotic patients has recently improved, transplant-free mortality remains high. LT is still the only curative treatment in this population. Yet, the increased relative scarcity of graft resource must be considered alongside the increased risk of losing a graft in the initial postoperative period when performing LT in "too sick to transplant" patients. Variables associated with poor immediate post-LT outcomes have been identified in large studies. Despite this, the performance of scores based on these variables is still insufficient. Consideration of a patient's comorbidities and frailty is an appealing predictive approach in this population that has proven of great value in many other diseases. So far, local expertise remains the last safeguard to LT. Using this expertise, data are accumulating on favourable post-LT outcomes in very high MELD populations, particularly when LT is performed in a situation of stabilization/improvement of organ failures in selected candidates. The absence of "definitive" contraindications and the control of "dynamic" contraindications allow a "transplantation window" to be defined. This window must be identified swiftly after admission given the poor short-term survival of patients with very high MELD scores. In the absence of any prospect of LT, withdrawal of care could be discussed to ensure respect of patient life, dignity and wishes. 
 Title: Approaches for patients with very high MELD scores
answer:
False


question:
Paragraph: Immaturity of the neonatal immune system is causative for high morbidity in calves and colostrum intake is crucial for acquiring passive immunity. Pathogenesis is promoted by reactive oxygen species accumulating at birth if counter-regulation is inadequate. The flavonol quercetin exerts antioxidative and anti-inflammatory effects that may enhance neonatal health. The aim of this work was to study effects of quercetin feeding on metabolic, antioxidative and inflammatory parameters in neonatal calves to investigate whether quercetin could compensate for insufficient colostrum supply. Twenty-eight newborn calves were assigned to two dietary groups fed colostrum or milk-based formula on day 1 and 2 and milk replacer thereafter. From day 2 onwards, 7 calves per diet group were additionally fed quercetin aglycone (50 mg/(kg body weight × day)). Blood samples were taken repeatedly to measure plasma concentrations of flavonols, glucose, lactate, total protein, albumin, urea, non-esterified fatty acids, triglycerides, cholesterol, insulin, glucagon, cortisol, immunoglobulins, fibrinogen, haptoglobin and serum amyloid A. Trolox equivalent antioxidative capacity, ferric reducing ability of plasma, thiobarbituric acid reactive species and F2isoprostanes were analyzed to evaluate plasma antioxidative status. Expression of tumor necrosis factor, interleukin-1α, interleukin-1β, serum amyloid A, haptoglobin, fibrinogen, Creactive protein, catalase, glutathione peroxidase and superoxide dismutase mRNA were measured in liver tissue on day 8. Plasma flavonol concentrations were detectable only after quercetin-feeding without differences between colostrum and formula feeding. Plasma glucose, lactate, total protein, immunoglobulins, triglycerides, cholesterol, trolox equivalent antioxidative capacity and thiobarbituric acid reactive species were higher after colostrum feeding. Body temperature, fecal fluidity and plasma concentrations of cortisol and PLOS ONE | Competing Interests: The authors have declared that no competing interests exist. haptoglobin were higher in formula-than in colostrum-fed groups. Hepatic mRNA expression of tumor necrosis factor was higher after quercetin feeding and expression of C-reactive protein was higher after formula feeding. Data confirm that colostrum improves neonatal health and indicate that quercetin feeding cannot compensate for insufficient colostrum supply. Quercetin Supplementation in Neonatal Calves with Respect to Different Diet PLOS ONE | 
 Title: Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits
answer:
True


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Paragraph: Causative pathogens of pneumonia in children can be diffi cult to identify. Streptococcus pneumoniae is the most common bacterial cause of pneumonia in children. Tachypnea is the most reliable clinical predictor of pneumonia in children. Laboratory and radiologic testing offers limited diagnostic benefi t. Probably the greatest challenge in the approach to children with pneumonia is that the microbiologic etiology is diffi cult to identify. This is primarily due to limitations of diagnostic testing modalities: blood cultures, antigen testing and antibody titers, and the need for invasive means to retrieve specimens. 1,4 Two studies illustrate our limited ability to diagnose the etiology of pneumonia in children. In a prospective study of 168 ambulatory children with CAP, an etiologic agent was identifi ed in only 43% of cases. 5 These included Streptococcus pneumoniae (27%), Mycoplasma pneumoniae (7%) and Chlamydia pneumoniae (6%). Patients with S. pneumoniae frequently had a mixed infection (40%). Of 157 patients tested for viral infection, 20% were positive by culture and/or direct fl uorescent antibody test. Viral etiologies identifi ed included respiratory syncytial virus (RSV), infl uenza viruses A and B, parainfl uenza viruses 1 and 3, adenovirus, enterovirus, cytomegalovirus, and herpes simplex virus. All viral isolates were identifi ed in children less than 8 years of age. 5 A similar study, in 254 hospitalized children with CAP, identifi ed a potential causative agent in 85% of cases. 6 Extensive diagnostic testing accounted for the relatively high yield in this study. Similar etiologies identifi ed, in decreasing frequency of occurrence, included S. pneumoniae, Haemophilus infl uenzae, M. pneumoniae, Moraxella catarrhalis, C. pneumoniae, Streptococcus pyogenes, and Chlamydia trachomatis. Viral etiologies included (most common to least common) RSV, rhinovirus, parainfl uenza viruses 1 through 3, adenovirus, infl uenza virus A and B, coronavirus, human herpesvirus 6, Epstein-Barr virus, and varicella-zoster virus. Mixed viralbacterial infections were detected in 30% of patients, and 41% of patients had more than one microbiologic agent identifi ed. Of interest, of 93 patients with S. pneumoniae, only one had a positive blood culture. The remaining 92 patients were diagnosed based solely on serologic evidence. 6 A prospective analysis seeking to identify etiologic agents via a pneumolysin-based polymerase chain reaction assay identifi ed a respiratory pathogen in 79% of 154 pediatric patients with lower respiratory tract infection. The most common etiologic agent was S. pneumoniae (44%). Of 68 patients with S. pneumoniae infection, 18% had a coinfection with another bacteria and 31% had a co-infection with a virus. Atypical agents (M. pneumoniae and C. pneumoniae) accounted for 22% of all infections (14% and 9%, respectively). The most common viral etiologies included 
 Title: Pneumonia Key Points
answer:

False


