In this task, you need to Translate Czech text to English.

Slouceniny, které jsou inhibitory kaspázy, zejména enzymu konvertujícího interleukin-1.beta. ("ICE"). Farmaceutické kompozice obsahující tyto slouceniny. Slouceniny a farmaceutické prostredky je obsahující jsou zejména velmi vhodné pro inhibici aktivity kaspázy a v dusledku toho je lze s výhodou použít jako cinidel proti onemocnením zprostredkovaným interleukinem-1 ("IL-1"), apoptózou, faktorem vyvolávajícím interferon gama ("IGIF") a interferonem-.gama. ("IFN-.gama."), vcetne zánetlivých onemocnení, autoimunních onemocnení, rozkladných onemocnení kosti, proliferativních poruch, infekcních onemocnení a degenerativních onemocnení. Zpusoby prípravy sloucenin podle vynálezu.
The present invention relates to compounds, which are caspase inhibitors, in particular interleukin-1 beta converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-("IL-1"), apoptosis-, interferon-gamma inducing factor-(IGIF), or interferon-gamma-("IFN-gamma") mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-gamma production and methods for treating interleukin-1, apoptosis-, and interferon-gamma-mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.