Given the task definition and input, reply with output. In this task, you are given a sentence. You are expected to write the name of the organism substances in the body mentioned in the input. Although there might be several correct answers, you need to write one of them.

 Furthermore , when ACT is overexpressed in transgenic mice , an increased plaque load in the brains of these mice and impaired spatial learning is observed [ 134 , 135 ] .

plaque