Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

[Q]: Question: Is expression of epigenetic modifiers significantly altered by exposure to secondhand smoke?
Answer: Quantification of the expression of genes encoding DNA methyltransferases (Dnmt1, Dnmt3a, Dnmt3b and Dnmt3l), methyl binding domain proteins (Mecp2, Mbd2 and Mbd3) and histone deacetylases (Hdac1 and Hdac2) by quantitative reverse-transcription polymerase chain reaction analysis showed modest but not statistically significant differences in the relative transcription of these key epigenetic regulators between SHS-exposed mice and age-matched controls. The non-significant changes in the expression of main epigenetic modifiers in SHS-exposed mice imply that SHS may predominantly induce genotoxic effects, particularly at non-tumorigenic doses, whereas epigenetic effects may only be secondary and manifest en route to tumor formation.
[A]: no


[Q]: Question: Are standard Radiographs Sufficient for Assessing Knee Mechanical Axis in Patients With Advanced Osteoarthritis?
Answer: Standard radiographs are not sufficient for determining MA, and HTA radiographs should be used while making surgical decisions aimed at correcting alignment to within ±3° or for assessing alignment post-total knee arthroplasty. In addition, surgical alignment outcomes reported in previous research using standard radiographs should be viewed with caution.
[A]: no


[Q]: Question: Do [ Hepatitis B virus replication and viral gene expressions affect CDC37 level in hepatocytes in vitro ]?
Answer: HBV replication and its gene expression have no effect on the level of CDC37 in hepatocytes in vitro.
[A]:
no


