In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: Histone deacetylases (HDAC) promote: 
 Options:  <1> A less condensed chromatin. <2> A weaker link between histones and DNA in nucleosomes. <3> The acetylation of lysine residues in histones. <4> That the poly (A) tail of the histone messenger RNAs be more extensive. <5> The termination of the transcription and the genetic silencing.
5