Given an abstract of a paper, generate a title for this paper such that conveys the key focus of the paper.

Q: Abstract: The present study was designed to investigate the relationship between proteinuria, focal sclerosis, and tubulo-interstitial changes in the evolution of renal damage in experimental nephrosis. We utilized an accelerated unilateral model of adriamycin (ADR) nephrosis characterized by morphological changes more severe than in the classical model. The first events in ADR-induced glomerulopathy were epithelial cell damage and proteinuria. Subsequently, tubular casts were formed at the distal level. The cast formation preceded the development of interstitial damage, which was determined by tubular obstruction and breaking of tubular basement membrane (TBM), which in turn promoted an interstitial inflammatory reaction. Despite the severity of tubulo-interstitial damage observed after a long period of heavy proteinuria, the incidence of focal segmental glomerulosclerosis (FSG) was very low. The results of the present study indicate that chronic proteinuria is not necessarily accompanied by the development of focal sclerosis. Tubulo-interstitial lesions appear to be the most important determinant for the progression of renal damage in this model.

A: Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy.
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Q: Abstract: Abnormal left ventricular diastolic performance, an early manifestation of hypertension in the heart, may precede the development of left ventricular hypertrophy. To assess effects of antihypertensive therapy on the heart, left ventricular mass (determined by echocardiography) and rapid left ventricular filling rate (determined by radionuclide ventriculography) were compared before and after 6 months of treatment of 16 patients. Nitrendipine (a dihydropyridine calcium channel blocker) was given alone or in combination with either propranolol or hydrochlorothiazide, or both, and significantly reduced blood pressure (156/103 +/- 12/7 to 137/89 +/- 10/6 mm Hg). In 6 of the 16 patients, left ventricular mass decreased by more than 10% (270 +/- 95 to 193 +/- 47 g, p less than 0.01); in the same patients, left ventricular filling rate increased (2.03 +/- 0.35 to 2.30 +/- 0.45 end-diastolic counts/s [EDC/s], p less than 0.01). In the one patient whose left ventricular mass increased (137 to 195 g), left ventricular filling rate decreased from 2.01 to 1.78 EDC/s. In the remaining nine patients who had no change in left ventricular mass, there was no significant changes in left ventricular filling. The changes in ventricular mass and filling could not be related to the extent of change in blood pressure or heart rate. These data suggest that regression of left ventricular mass during antihypertensive therapy with nitrendipine is accompanied by improved diastolic function.

A: Improved left ventricular filling accompanies reduced left ventricular mass during therapy of essential hypertension.
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Q: Abstract: Maquet recommended 2-2.5 cm of anterior tibial tubercle elevation for patients with symptomatic osteoarthrosis of the patellofemoral joint. Fifty-three patients with osteoarthrosis were divided into three groups. The first 12 patients were treated by the classical Maquet procedure; 11 were totally relieved of patellofemoral pain, but there was one failure and five complications. In the second group of 32 patients, the patella was realigned within its groove to alter tracking of the patella to the proximal femoral condyles when necessary. Fish-mouthing technique and insertion of a drain after surgery were done. After a two-year follow-up examination, there were two failures and five complications. A third group of nine patients was treated with Ferguson's modification of Maquet's operation using a 1.25-cm tibial tubercle elevation through a transverse incision; two of the nine had complications, subsequently treated successfully by converting Ferguson's operation into the Maquet operation, as modified for Group II. The modified Maquet procedure can be an effective and reliable treatment of patellofemoral arthrosis with a relatively low incidence of complications.

A:
The Maquet procedure--anterior displacement of the tibial tubercle. Indications, contraindications, and precautions.
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