Detailed Instructions: In this task, you are given a text of many news articles seperated by special token "|||||". Your task is to summarize them.
Problem:Importance Between 40% and 50% of women in Western countries use complementary therapies to manage menopausal symptoms. 
  
 Objective To determine the association of plant-based therapies with menopausal symptoms, including hot flashes, night sweats, and vaginal dryness. 
  
 Data Sources The electronic databases Ovid MEDLINE, EMBASE, and Cochrane Central were systematically searched to identify eligible studies published before March 27, 2016. Reference lists of the included studies were searched for further identification of relevant studies. 
  
 Study Selection Randomized clinical trials that assessed plant-based therapies and the presence of hot flashes, night sweats, and vaginal dryness. 
  
 Data Extraction Data were extracted by 2 independent reviewers using a predesigned data collection form. 
  
 Main Outcomes and Measures Hot flashes, night sweats, and vaginal dryness. 
  
 Results In total, 62 studies were identified, including 6653 individual women. Use of phytoestrogens was associated with a decrease in the number of daily hot flashes (pooled mean difference of changes, −1.31 [95% CI, −2.02 to −0.61]) and vaginal dryness score (pooled mean difference of changes, −0.31 [95% CI, −0.52 to −0.10]) between the treatment groups but not in the number of night sweats (pooled mean difference of changes, −2.14 [95% CI, −5.57 to 1.29]). Individual phytoestrogen interventions such as dietary and supplemental soy isoflavones were associated with improvement in daily hot flashes (pooled mean difference of changes, −0.79 [−1.35 to −0.23]) and vaginal dryness score (pooled mean difference of changes, −0.26 [−0.48 to −0.04]). Several herbal remedies, but not Chinese medicinal herbs, were associated with an overall decrease in the frequency of vasomotor symptoms. There was substantial heterogeneity in quality across the available studies, and 46 (74%) of the included randomized clinical trials demonstrated a high risk of bias within 3 or more areas of study quality. 
  
 Conclusions and Relevance This meta-analysis of clinical trials suggests that composite and specific phytoestrogen supplementations were associated with modest reductions in the frequency of hot flashes and vaginal dryness but no significant reduction in night sweats. However, because of general suboptimal quality and the heterogeneous nature of the current evidence, further rigorous studies are needed to determine the association of plant-based and natural therapies with menopausal health. ||||| Women who have already passed through the menopause may be able to have children following a blood treatment usually used to heal wounds 
  
 Peter Dazeley/Getty 
  
 MENOPAUSE need not be the end of fertility. A team claims to have found a way to rejuvenate post-menopausal ovaries, enabling them to release fertile eggs, New Scientist can reveal. 
  
 The team says its technique has restarted periods in menopausal women, including one who had not menstruated in five years. If the results hold up to wider scrutiny, the technique may boost declining fertility in older women, allow women with early menopause to get pregnant, and help stave off the detrimental health effects of menopause. 
  
 “It offers a window of hope that menopausal women will be able to get pregnant using their own genetic material,” says Konstantinos Sfakianoudis, a gynaecologist at the Greek fertility clinic Genesis Athens. 
  
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 “It is potentially quite exciting,” says Roger Sturmey at Hull York Medical School in the UK. “But it also opens up ethical questions over what the upper age limit of mothers should be.” 
  
 Women are thought to be born with all their eggs. Between puberty and the menopause, this number steadily dwindles, with fertility thought to peak in the early 20s. Around the age of 50, which is when menopause normally occurs, the ovaries stop releasing eggs – but most women are already largely infertile by this point, as ovulation becomes more infrequent in the run-up. The menopause comes all-too-soon for many women, says Sfakianoudis. 
  
 The age of motherhood is creeping up, and more women are having children in their 40s than ever before. But as more women delay pregnancy, many find themselves struggling to get pregnant. Women who hope to conceive later in life are increasingly turning to IVF and egg freezing, but neither are a reliable back-up option (see “The pregnancy pause“). 
  
 The menopause also comes early – before the age of 40 – for around 1 per cent of women, either because of a medical condition or certain cancer treatments, for example. 
  
 “It offers hope that menopausal women will be able to get pregnant using their own genetic material“ 
  
 To turn back the fertility clock for women who have experienced early menopause, Sfakianoudis and his colleagues have turned to a blood treatment that is used to help wounds heal faster. 
  
 Platelet-rich plasma (PRP) is made by centrifuging a sample of a person’s blood to isolate growth factors – molecules that trigger the growth of tissue and blood vessels. It is widely used to speed the repair of damaged bones and muscles, although its effectiveness is unclear. The treatment may work by stimulating tissue regeneration. 
  
 Sfakianoudis’s team has found that PRP also seems to rejuvenate older ovaries, and presented some of their results at the European Society of Human Reproduction and Embryology annual meeting in Helsinki, Finland, this month. When they injected PRP into the ovaries of menopausal women, they say it restarted their menstrual cycles, and enabled them to collect and fertilise the eggs that were released. 
  
 “I had a patient whose menopause had established five years ago, at the age of 40,” says Sfakianoudis. Six months after the team injected PRP into her ovaries, she experienced her first period since menopause. 
  
 Sfakianoudis’s team has since been able to collect three eggs from this woman. The researchers say they have successfully fertilised two using her husband’s sperm. These embryos are now on ice – the team is waiting until there are at least three before implanting some in her uterus. 
  
 The team isn’t sure how this technique works, but it may be that the PRP stimulates stem cells. Some research suggests a small number of stem cells continue making new eggs throughout a woman’s life, but we don’t know much about these yet. It’s possible that growth factors encourage such stem cells to regenerate tissue and produce ovulation hormones. “It’s biologically plausible,” says Sturmey. 
  
 Fertilised eggs 
  
 Sfakianoudis’s team says it has given PRP in this way to around 30 women between the ages of 46 and 49, all of whom want to have children. The researchers say they have managed to isolate and fertilise eggs from most of them. 
  
 “It seems to work in about two-thirds of cases,” says Sfakianoudis. “We see changes in biochemical patterns, a restoration of menses, and egg recruitment and fertilisation.” His team has yet to implant any embryos in post-menopausal women, but hopes to do so in the coming months. 
  
 PRP has already been helpful for pregnancy in another group of women, says Sfakianoudis. Around 10 per cent of women who seek fertility treatment at his clinic have a uterus that embryos find difficult to attach to – whether due to cysts, scarring from miscarriages or having a thin uterine lining. “They are the most difficult to treat,” says Sfakianoudis. 
  
 But after injecting PRP into the uteruses of six women who had had multiple miscarriages and failed IVF attempts, three became pregnant through IVF. “They are now in their second trimester,” says Sfakianoudis. 
  
 Fertility aside, the technique could also be desirable for women who aren’t trying to conceive. The hormonal changes that trigger menopause can also make the heart, skin and bones more vulnerable to ageing and disease, while hot flushes can be very unpleasant. Many women are reluctant to take hormone replacement therapy to reduce these because of its link with breast cancer. Rejuvenating the ovaries with PRP could provide an alternative way to boost the supply of youthful hormones, delaying menopause symptoms. 
  
 Steve Gschmeissner/SPL 
  
 However, Sfakianoudis’s team hasn’t yet published any of its findings. “We need larger studies before we can know for sure how effective the treatment is,” says Sfakianoudis. 
  
 “One woman had been in menopause for 5 years. Six months after treatment, she had a period“ 
  
 Some have raised concerns about the safety and efficacy of the procedure, saying the team should have tested the approach in animals first. “This experiment would not have been allowed to take place in the UK,” says Sturmey. “The researchers need to do some more work to make sure that the resulting eggs are OK,” says Adam Balen at the British Fertility Society. 
  
 To know if the technique really does improve fertility, the team will also need to carry out randomised trials, in which a control group isn’t given PRP. 
  
 Virginia Bolton, an embryologist at Guy’s and St Thomas’ Hospital in London, is also sceptical. “It is dangerous to get excited about something before you have sufficient evidence it works,” she says. New techniques often find their way into the fertility clinic without strong evidence, thanks to huge demand from people who are often willing to spend their life savings to have a child, she says. 
  
 If the technique does hold up under further investigation, it could raise ethical questions over the upper age limits of pregnancy – and whether there should be any. “I lay awake last night turning this over in my mind,” says Sturmey. “Where would the line be drawn?” 
  
 Health issues like gestational diabetes, pre-eclampsia and miscarriage are all more common in older women. “It would require a big debate,” says Sturmey. 
  
 Sperm home test kit How are the little swimmers doing? Low sperm counts or poor sperm quality are behind around a third of cases of couples who can’t conceive. A visit to a clinic for a test can be awkward, but a smartphone-based system lets men determine whether that’s necessary by checking their fertility at home. Men often find it embarrassing to give a semen sample at a clinic, says Yoshitomo Kobori at the Dokkyo Medical University Koshigaya Hospital in Japan. So Kobori devised an alternative. “I thought a smartphone microscope could be an easy way to look at problems with male fertility,” he says. Kobori and his colleagues came up with a lens less than a millimetre thick that can be slotted into a plastic “jacket”. Clipped on to the camera of a smartphone, it magnifies an image by 555 times – perfect for looking at sperm. To do a home test, a man would apply a small amount of semen to a plastic sheet around five minutes after ejaculation and press it against the microscope. Watch them swim The phone’s camera can then take a 3-second video clip of the sperm. When viewed enlarged on a computer screen, it is easy for someone to count the total number of sperm and the number that are moving – key indicators of fertility. Kobori says the system works as well as the software used in fertility clinics. When the team ran 50 samples through both systems, they got almost identical results. The work was presented at the European Society of Human Reproduction and Embryology meeting in Helsinki this month. The system can’t assess the ability of sperm to fertilise an egg. “This method is only the simple version of semen analysis,” says Kobori. But that could be enough for men to identify potential fertility problems, and decide whether to seek help from a doctor. 
  
 This article appeared in print under the headline “Reversing the menopause” 
  
 Leader: “Who should we believe when it comes to fertility?” |||||
Solution:
The hot flashes, night sweats, and vaginal dryness characteristic of menopause may no longer also signal the end of a woman's fertility thanks to a blood treatment used to heal wounds. Presenting their findings at the European Society of Human Reproduction and Embryology annual meeting in Helsinki, Finland, this month, researchers in Greece said they were able to reverse menopause in roughly 30 women, including one who entered menopause at 40 but five years later menstruated again, reports New Scientist. The team has collected three eggs from her and, using her husband's sperm, fertilized two into embryos that they plan to implant into her uterus. Still, an outside researcher says, the development "opens up ethical questions over what the upper age limit of mothers should be." The team reports that roughly 1% of women become infertile before they turn 40 thanks to certain medical conditions and cancer treatments. "It offers a window of hope that menopausal women will be able to get pregnant using their own genetic material," says gynecologist Konstantinos Sfakianoudis. The team injected a woman's ovaries with a platelet-rich plasma—or PRP, which is made with a person's own blood to trigger tissue and blood vessel growth and has been used by the likes of Tiger Woods to speed healing from soft-tssue injuries, notes Forbes—to effectively rejuvenate them and trigger menstrual cycles. They're not yet sure exactly how it works, but they've managed to fertilize eggs from nearly all of the 30 women they studied, who are between 45 and 49 and want to have children. In related news, a meta analysis published in JAMA found that some "natural" remedies, though not Chinese "medicinal" herbs, may slightly improve certain symptoms of menopause. (Heard of snowflake moms?)