You will be given a definition of a task first, then some input of the task.
In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: When in a laboratory report we observed that the patient presents an increase in the concentration of transferrin with a decrease in its saturation, we can think of: 
 Options:  <1> Pernicious anemia. <2> Sickle-cell anaemia. <3> Thalassemia major. <4> Hereditary spherocytosis. <5> Anemia due to iron deficiency.
Output:
5