instruction:
You are given a background paragraph that describes one or more causal or qualitative relationships such as a relationship in economics or a scientific law and a story that makes use of the concepts or the relationship described in the provided paragraph. You need to come up with a question about the story that requires an understanding of the relationship described in the background paragraph. The generated question should not be answerable without both the background and story. Write a question about the story that requires a relationship in the background paragraph to answer. Check whether your question requires both the background paragraph and the story to answer. If your question can be answered by only one of these, try to rewrite your question so that it requires both. Note that "flipping" a word in the question can give rise to a new question where the answer will be different from the original question. Often, "flipping" a word gives rise to flipping the direction of the relationship, for example, from "increase" to "decrease."
question:
Background Paragraph: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. 
Story: Two university students studied different types of drugs for their exams. Kate studied statins, while Carol studied anti-depressants.
answer:
Which student learned less about an inhibitor of HMG-CoA reductase?


question:
Background Paragraph: As the atoms first begin to interact, the attractive force is stronger than the repulsive force and so the potential energy of the system decreases, as seen in the diagram. Remember that the lower potential energy increases the stability of the system. As the two hydrogen atoms move closer and closer together, the potential energy continues to decrease. Eventually, a position is reached where the potential energy is at its lowest possible point. If the hydrogen atoms move any closer together, a third interaction begins to dominate and that is the repulsive force between the two positively-charged nuclei. This repulsive force is very strong as can be seen by the sharp rise in energy at the far left of the diagram. 
Story: Ken is a scientist who studies atomic systems. He is currently responsible for studying two systems that they are referring to as Omega and Alpha. These two systems are essential to the research that is being done to potentially allow humans to travel to Mars in a reasonable amount of time. Little is known about these systems currently, but scientists have observed that Omega has been steadily gaining more potential energy. Alpha has been rapidly losing potential energy. Ken is hoping to discern why this is happening and try to utilize his findings to further space exploration.
answer:
Which system is less stable?


question:
Background Paragraph: An enzyme is a protein that acts as a biological catalyst. Recall that a catalyst is a substance that increases the rate of a chemical reaction without itself being consumed in the reaction. Cellular processes consist of many chemical reactions that must occur quickly in order for the cell to function properly. Enzymes catalyze most of the chemical reactions that occur in a cell. A substrate is the molecule or molecules on which the enzyme acts. In the urease catalyzed reaction above, urea is the substrate. The Figure below diagrams a typical enzymatic reaction. 
Story: Robert is a scientist that is analyzing the skin cells he obtained from a new species of spider. He is comparing two cells side by side. He notices that the cell on the left, cell A, does not have any enzymes present. The cell on the right, cell B, however contains a large number of enzymes.
answer:

Which cell will have faster chemical reactions?


