In this task, you are given a sentence in the Spanish language. Your task is to translate the Spanish sentence into the English language.

En el tratamiento del trastorno depresivo mayor, ¿qué ventajas tienen los inhibidores selectivos de la recaptación de la serotonina (ISRS) en comparación a los antidepresivos tricíclicos?
In the treatment of major depressive disorder, what are the advantages of selective serotonin reuptake inhibitors (SSRIs) compared to tricyclic antidepressants?