Given the task definition and input, reply with output. In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: With respect to the distribution coefficient of a solute between two partially miscible liquids: 
 Options:  <1> Because it is a quotient between solute concentrations in the two phases, it is independent of temperature. <2> It does not depend on the total amount of solute in both parts. <3> It is useful to determine the molar mass of the solute. <4> If one phase is water and the other an organic solvent, it is usually used in medical and environmental chemistry to know the distribution of drugs and contaminants between these two types of media. <5> It only has physical significance when the liquid phases are in contact through a semipermeable membrane.

4