In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: The enzymes present inside the virion of the poxviruses are necessary for the replication of their genetic material because: 
 Options:  <1> Its genome is single-stranded DNA (-). <2> Its genome is single-stranded RNA (-). <3> They replicate in the cell cytoplasm. <4> It contains a very high percentage of unusual nitrogenous bases such as inosine. <5> At the beginning of the infection, a blockage of the transcriptional system of the host cell occurs.
3