Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).

Example Input: Abstract: The key determinants of alveolar capillary perfusion are transit times and the extent of recruitment. Capillaries are known to be heavily recruited in the dependent lung, but there are no direct data that bear on how capillary transit times might be affected by gravity. We directly determined mean capillary transit times on the surface of the upper, middle, and lower lung by measuring the passage of fluorescent dye through the capillaries using in vivo television microscopy. In anesthetized dogs, mean capillary transit times averaged 12.3 s in the upper lung, 3.1 s in the midlung, and 1.6 s in the lower lung. This near order of magnitude variation in speed of blood transit establishes that there is a vertical gradient of capillary transit times in the lung. As expected, dependent capillary networks were nearly fully recruited, whereas relatively few capillaries were perfused in the upper lung. The lengthy transit times and sparsely perfused capillary beds in the upper lung combine to provide a substantial part of pulmonary gas exchange reserve. 
 Which is the apt title for the abstract? option1: Vertical gradient of pulmonary capillary transit times. option2: Female frosh fare fine [letter]
Example Output: Vertical gradient of pulmonary capillary transit times.

Example Input: Abstract: The purpose of the study was to compare the renal effects of low doses of exogenous dopamine to assess the responsiveness of renal dopaminergic receptors in normotensive and hypertensive subjects. Eight hypertensive patients and seven normotensive volunteer subjects were studied. Inulin and para-aminohippuric (PAH) clearances, natriuresis, and fractional excretion of sodium increased significantly after intravenous dosing with dopamine (2 micrograms/min/kg) in both groups. These increases were significantly higher in hypertensive than in normotensive subjects: 31.8% +/- 3.7% vs. 16.2% +/- 1.2% for inulin clearance (P less than 0.01), 83.3% +/- 10.5% vs. 41.1% +/- 3.4% for PAH clearance (P less than 0.01), and 331% +/- 38% vs. 216% +/- 26% for natriuresis (P less than 0.01). These findings suggest hyperresponsiveness to dopamine during hypertension. This enhanced response to exogenous dopamine can be considered as a further argument favoring the existence of a deficit in dopaminergic activity during hypertension. Dopamine also induced a significant reduction in blood pressure and increased heart rate in hypertensive subjects but no significant change in blood pressure and heart rate occurred in normotensive subjects. 
 Which is the apt title for the abstract? option1: Enhanced dopamine renal responsiveness in patients with hypertension. option2: Urine protein excretion in acute pancreatitis.
Example Output: Enhanced dopamine renal responsiveness in patients with hypertension.

Example Input: Abstract: Ewes were treated systemically during the periovulatory period with the antihistamines diphenhydramine (H1-receptor antagonist) and(or) cimetidine (H2-receptor antagonist). None of the treatments prevented ovulation. However, the combination of drugs inhibited subsequent function of the corpus luteum (CL) as assessed by serum measurements of progesterone. Administration of antihistamines did not alter pituitary secretion of LH. Injection of small quantities of diphenhydramine and cimetidine into the antrum of the preovulatory follicle also caused aberrant luteal activity, but no blockade of ovulation. Intrafollicular injection of histamine reversed the inhibitory influence of antihistamines on the CL. Antihistamines suppressed preovulatory thecal edema and antral influx of plasma transudate containing LH. Thus, the effects of antihistamines appear to have been exerted at the follicular level. Function of matured CL was not compromised by peripheral administration of antihistamines. Actions of histamine within the preovulatory ovine follicle do not appear to be a prerequisite for ovulation, but apparently do have an impact on ensuing luteal function. We propose that a hyperemic reaction to histamine in preovulatory follicles enhances vascular filtration of LH. As a consequence, maximal permeation of the avascular granulosal layer of the follicle by LH leads to a normal luteinization response. 
 Which is the apt title for the abstract? option1: Ovarian function in ewes treated with antihistamines. option2: Therapy-related leukemia and myelodysplastic syndrome: clinical, cytogenetic, and prognostic features.
Example Output:
Ovarian function in ewes treated with antihistamines.

