Given the task definition, example input & output, solve the new input case.
In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
Example: Question: A 13-year-old girl is operated on due to Hirschsprung illness at 3 months of age. Which of the following tumors is more likely to be present? 
 Options: <1> Abdominal neuroblastoma <2> Wilms tumor <3> Mesoblastic nephroma <4> Familial thyroid medullary carcinoma.
Output: 2
The answer to the given question should be a tumor, therefore Wilms tumor is the correct answer for the given question.

New input case for you: Question: When in a laboratory report we observed that the patient presents an increase in the concentration of transferrin with a decrease in its saturation, we can think of: 
 Options:  <1> Pernicious anemia. <2> Sickle-cell anaemia. <3> Thalassemia major. <4> Hereditary spherocytosis. <5> Anemia due to iron deficiency.
Output:
5