Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: In this phase 2 proof-of-concept study we examined the safety and efficacy of selexipag, an orally available, selective prostacyclin receptor (IP receptor) agonist, as a treatment for pulmonary arterial hypertension (PAH). 43 adult patients with symptomatic PAH (receiving stable endothelin receptor antagonist and/or a phosphodiesterase type-5 inhibitor therapy) were randomised three to one to receive either selexipag or placebo. Dosage was up-titrated in 200-g increments from 200 g twice daily on day 1 to the maximum tolerated dose by day 35 (maximum allowed dose of 800 g twice daily). Change in pulmonary vascular resistance at week 17 expressed as a percentage of the baseline value was the primary efficacy end-point, and was analysed in the per protocol set first and then in the all-treated set to assess robustness of results. A statistically significant 30.3% reduction in geometric mean pulmonary vascular resistance was observed after 17 weeks' treatment with selexipag compared with placebo (95% confidence limits -44.7- -12.2; p=0.0045, Wilcoxon rank sum test). This was supported by a similar result from the all-treated set. Selexipag was well tolerated with a safety profile in line with the expected pharmacological effect. Our results encourage the further investigation of selexipag for the treatment of PAH.
Example Output: Selexipag is used for which disease?

Example Input: Lewy bodies and coarse Lewy neurites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions are present in the axonal processes of neurons.
Example Output: Which is the primary protein component of Lewy bodies?

Example Input: English is a language spoken all around the world. There are more than 42 countries where the majority of the people speak English. Most native speakers of English are found in the United Kingdom, the United States, Canada, Australia, South Africa, Ireland and New Zealand. In total, for more than 375 million people, English is their mother tongue. An equal number of people learn English as a second language. These people will perhaps speak the language of their own country at home with their family, but the language of the government, schools, newspapers and TV is English. However, the number of people who learn English as a foreign language is more than 750 million. Everywhere in the world children go to school to learn English. In China, students learn English at school as a foreign language, except for those in hong Kong, where many people speak English as a first or a second language. In only fifty years, English has developed into the language most widely spoken and used in the world. English is the working language of most international organizations, international trade and tourism. English is also the language of global culture, such as popular music and the Internet. You can listen to English songs on the radio or use English to communicate with people around the world through the Internet. With so many people communicating in English every day, it will become more and more important to have a good knowledge of English.
Example Output:
In China we are learning English as a     .

