The Lopukhin family was a noble family of the Russian Empire, forming one of the branches of the Sorokoumova-Glebov family. One of its members, Eudoxia Lopukhina, married Peter the Great. When Pyotr Lopukhin's son died childless, the family's princely title passed to
Can we infer the following?
Eudoxia had four children.
It's impossible to say