Fill in the response. 
- What does it mean when a catalyst binds irreversibly?.
- The catalyst resting state consists entirely of the bound complex, and [A] is no longer present in the rate law; changing [A] will have no effect on reaction rate because the catalyst is already completely bound and reacting as rapidly as "k" allows..
- Are there any other interesting aspects about this article?.
- The simplest case of saturation kinetics is the well-studied Michaelis-Menten model for enzyme kinetics..
- Why do enzymes bind irreversibly?.
- While a reaction may exhibit one set of kinetic behavior at early conversion, that behavior may change due to: In the case of saturation kinetics described above, provided that [A] is not present in a large excess relative to [B], saturation conditions will only apply at the beginning of the reaction..
- What else can you tell me about irreversible binding?.
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As the substrate is consumed, the concentration decreases and eventually [A] is no longer sufficient to completely overwhelm [Cat].