Fill in the response. A dialog between 2 people:
[-] What is the pathogenesis of HHV-8-associated MCD?.
[-] In HHV-8-associated MCD the HHV-8 virus infects B cells and plasmablasts in lymph nodes and causes infected cells to release proinflammatory cytokines, signaling molecules that increase the activity of immune cells..
[-] Are there any other interesting aspects about this article?.
[-] In particular, HHV-8 infection of immune cells leads to increased levels of Interleukin-6 (IL-6), a cytokine known to play a role in other forms of Castleman disease..
[-] How does interleukin play a role?.
[-] The HHV-8 virus contains a gene coding for a viral variant of the IL-6 molecule..
[-] What happens to the body after it's release?.
[-] Cells infected by HHV-8 produce the viral variant of IL-6 and normal human IL-6, both of which contribute to the increased B cell proliferation and clinical findings seen in HHV-8-associated MCD..
[-] How is it diagnosed?.
[-] HHV-8-associated MCD is diagnosed based on patient history, physical exam, laboratory testing, radiologic imaging, and microscopic analysis (histology) of biopsied tissue from an enlarged lymph node..
[-] Are there any other ways it's been diagnosed?.
[-] 
Formal criteria for the diagnosis of HHV-8-associated MCD have not been published; however, diagnosis requires enlargement of lymph nodes in multiple lymph node regions (typically confirmed with radiologic imaging), histologic changes consistent with HHV-8-associated MCD on biopsy of an enlarged lymph node, and confirmation of HHV-8 infection by LANA-1 lymph node staining or peripheral blood polymerase chain reaction for HHV-8.