By Matt Chorley, Mailonline Political Editor David Cameron has intervened in the UK’s biggest ever takeover, warning he is 'determined' to protect British jobs as US drugs giant Pfizer stepped up its bid for AstraZeneca. Viagra maker Pfizer said it hoped the new offer of £50 a share – up 7 per cent on a bid in January – would speed up a move towards a ‘combination’ between the two drugs firms, but UK-based AstraZeneca rejected the move. The Prime Minister revealed he had sought 'assurances' from Pfizer about protecting jobs, and insisted he would not allow an 'abject surrender' of a British firm.

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British Prime Minister - to fight hard for Britain's