Fill in the response. See the 2 person dialog: [+] What is the role of LTBP in TGF- ⁇  signaling? [+] For example, LTBP-4 is reported to bind only to TGF-β1, thus, mutation in LTBP-4 can lead to TGF-β associated complications which are specific to tissues that predominantly involves TGF-β1. [+] Are there any other interesting aspects about this article? [+] Moreover, the structural differences within the LTBP’s provide different latent TGF-β complexes which are selective but to specific stimuli generated by specific activators. [+] What are some of the diseases caused by TGF-? ? [+] Plasmin and a number of Matrix metalloproteinases (MMP) play a key role in promoting tumor invasion and tissue remodeling by inducing proteolysis of several ECM components. [+] How does the body respond to TGF-?? [+] 
The TGF-β activation process involves the release of the LLC from the matrix, followed by further proteolysis of the LAP to release TGF-β to its receptors.