If this is the response, what came before? Response In addition to acetylation patterns of histones, methylation patterns at promoter regions of DNA can regulate RNA polymerase access to a given template.
DIALOG: *What is the order of events in the primary transcript? *Acetylation of histones induces repulsion between negative components within nucleosomes, allowing for RNA polymerase access. *What else is significant about the order of events? *Deacetylation of histones stabilizes tightly coiled nucleosomes, inhibiting RNA polymerase access. *Are there any other interesting aspects about this article? *