Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Imatinib is one of the most recent medications used for the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). It is an orally administered protein-tyrosine kinase inhibitor, an enzyme which is produced by BCR-ABL fusion which results from translocation of 9:22 chromosome (Philadelphia chromosome). Imatinib blocks proliferation and induces apoptosis of BCR-ABL-expression in CML. Many side effects produced by imatinib have been documented but its induction of hepatotoxcity has been rarely reported. Only a few cases so far have been reported in the literature and almost all were in females. We describe another case of hepatotoxicity due to imatinib in a 17-year old female with clinical, laboratory and histopathological changes. The case described here suggests that imatinib may also induce immune hepatitis, in some patients.
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

It was the last KH-2 Corona' satellite, which was based on an Agena-B. The launch of Discoverer 28 occurred at 00:01 UTC on 4 August 1961.
When was the launch date of Discoverer 28?

Fred Fish died at his home in Idaho on Friday April 20, 2007 of a heart attack.

From what did Fred Fish die?

