You will be given a definition of a task first, then some input of the task.
In this task, you are given Wikipedia articles on a range of topics, we ask you to write a question based on the content of the articles that can be answered in a binary manner i.e. True or False.

Pyruvate dehydrogenase complex -- Upon entry to the mitochondria, the pyruvate is decarboxylated, producing acetyl CoA. This irreversible reaction traps the acetyl CoA within the mitochondria (the acetyl-CoA can only be transported out of the mitochondrial matrix under conditions of high oxaloacetate via the citrate shuttle, a TCA intermediate that is normally sparse). The carbon dioxide produced by this reaction is nonpolar and small, and can diffuse out of the mitochondria and out of the cell.
Output:
is the conversion of pyruvate to acetyl coa reversible