Fill in the response. See the 2 person dialog:
 * what are the different steps of chromosome duplication.
 * association Cdc7 with Dbf4 activates its kinase activity..
 * what are the similarities and differences between the two processes.
 * In a similar manner to cyclin levels, dbf4 levels fluctuate throughout the cell cycle..
 * what is the significance of the two processes.
 * In vitro biochemical studies have shown that Cdc7-Dbf4 phosphorylates individual components of the Mcm complex..
 * are there any other interesting aspects about this article?.
 * It also seems to be involved in the recruitment of Cdc45 to chromatin at the time of initiation..
 * what are the different steps of the two processes.
 * 
In Xenopus eggs, Cdc45 has been shown to interact with DNA polymerase α, and in yeast, mutations in Cdc45 prevent assembly of DNA pol α at origins, suggesting that Cdc45 recruits DNA pol α to chromatin in a Cdc7/Dbf4 dependent manner.