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Marine Le Pen told BBC Newsnight ideas UKIP leader Nigel Farage defends are "very similar" to those of her party.
In a statement, UKIP said it was "not interested in any deal" with Ms Le Pen or her party because of "prejudice and anti-Semitism in particular" in the FN.
UKIP this week appeared to align itself with a French Eurosceptic party.
Speaking on Newsnight, Ms Le Pen insisted that Front National's campaign against the European Union was in line with UKIP's Eurosceptic policies.
She said her "arms will be open" to Mr Farage if he were willing to "join up in a common plan to fight the European Union."
"As long as it serves the interests of the European people" she added.
Ms Le Pen said that although there are "strategic or tactical differences" between the two parties, there were "obvious similarities" in polices such as "refusal of massive immigration" and  "peoples' freedom to decide for themselves".
"People have progressively realised the EU has brought them nothing but unhappiness, devastation, identity loss, and unprotected frontiers," she said.
"If he understood how serious the EU's situation is, he would support the reunion of all patriotic movements, and he would not use tactics and strategy," she told Newsnight.
UKIP said that despite "efforts that Ms Le Pen has made at modernisation" of the Front National, they were "not interested in any deal" because "in the parties DNA there is prejudice and anti-Semitism in particular".
On Tuesday, Mr Farage appeared to form an allegiance with a fellow Eurosceptic party, Debout la Republique (DLR: Stand up, the Republic!) at a rally in Paris.
The party is the political vehicle of Nicolas Dupont-Aignan, a 52-year-old dissident Gaullist who feels the mainstream centre-right UMP party has sold out to Brussels. He received less than 2% at the last presidential vote.
"Nigel Farage appears to have chosen to campaign along with a candidate who reaches scores of 1% in France," Ms Le Pen said.
"I am still wondering why he made that choice, as Nicolas Dupont Aignan's political choices are very close to ours."
However, Ms Le Pen said that this would not stop her welcoming collaboration with Mr Farege and UKIP.
She said she would rise above "personal considerations" and added Mr Farage is "undoubtedly is a charismatic leader."
See the interview on Newsnight on 17 April at 22:30 BST on BBC Two or afterwards on the BBC iPlayer.
The leader of the French far right-wing Front National (FN) party has said that she would welcome collaboration with UKIP with "open arms".

Selby had been due to face Hermogenes Castillo, also of Nicaragua, but the 21-year-old has pulled out at the last minute with a hand injury.
The 27-year-old became the fastest Welsh boxer to a British title with victory over Louis Norman in May.
He is undefeated in five fights since turning professional in 2015.
IBF featherweight champion Lee Selby says brother Andrew is a "natural fighter".
"I'm not saying it because he's my brother but he's one of the most talented boxers I've seen," he said.
"He does stuff in the gym that you cannot teach. He's just a natural fighter."
Former world featherweight champion Barry McGuigan said Selby is "one of the best talents" he has ever seen.
Older brother Lee has sparred against his sibling in the build-up to Friday's fight at Meadowbank Sports Centre in Edinburgh.
"He's looking brilliant and I've got a black eye to prove it," he told BBC Radio Wales Sport.
"It's like trying to swat a fly and you get stung by a bee. That's what it's like chasing round the ring - you just can't hit him.
"He hits you about five times before you move your hands."
After the Edinburgh fight, the younger Selby will face a yet to be announced opponent on 18 November at London's Wembley Arena.
Lee Selby has said he is likely to defend his IBF featherweight title against Jonathan Victor Barros in mid-December in the United States.
British champion Andrew Selby will now face Nicaraguan Felix Moncada in a 10-round international flyweight contest in Edinburgh on Friday.

Wing James started against Ireland and Scotland, while flanker Lydiate made appearances off the bench.
Full-back Anscombe missed the game in Ireland with injury but was a second half substitute in the 27-23 win over Scotland in Cardiff.
Welsh squad players based in Wales do not have to be released during the Six Nations Championship.
With the international tournament taking a break, all four Welsh regions are in action.
On Friday, 19 February Ospreys play Edinburgh while the Dragons are away to Benetton Treviso.
Saturday sees the Blues at home to Leinster and Scarlets travel to Ulster on Sunday.
Squad players based outside Wales have already been released to their clubs.

Dan Lydiate, Tom James and Gareth Anscombe are among 13 players released by Wales to play for their regions.

