Instructions: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
Input: The VISTA-16 trial of varespladib, a secretory phospholipase A2 (sPLA2) inhibitor, in patients with an acute coronary syndrome was terminated prematurely owing to futility and a signal towards harm. Despite these discouraging results, therapies that target inflammation to modify pathways in atherogenesis remain an area of active investigation.
Output:
Which enzyme is inhibited by Varespladib?