In this task, given a sentence in the English language, your task is to convert it into the Japanese language.
One example: Test subjects will be administered either a placebo or PA-457 that will be taken in combination with the medication they already take.
Solution is here: 被験者は、彼らがすでに服用している薬剤と一緒に偽薬またはPA-457を与えられる。
Explanation: The above sentence is correctly translated from English to Japanese.

Now, solve this: "Is the biggest proponent of George Bush’s tired, failed policies ready to bring about change?"
Solution:
「ジョージ・ブッシュの最大の支持者は、変化をもたらすために準備万端の、失敗した政策に疲れたのか？」