Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: If you want to become a fluent English speaker you should take some advice: There are four skills in learning English. They are reading, listening, speaking, and writing. The most important thing you must remember is that if you want to improve your speaking and writing skills you should first master the skills of reading and listening. Read as much as you can. But your reading must be active. It means that you must think about the meaning of the sentence, the meanings of the unfamiliar words, etc. There is no need for you to pay much attention to grammars or try to understand all the unfamiliar words you _ , but the fact that you see them for the first time and recognize them whenever you see them, for example in other passages or books, is enough. It would be better to prepare yourself a notebook so you can write down the important words or sentences in it. As for listening, there are two choices: besides reading, you can listen every day for about 30 minutes. You can only pay attention to your reading and become skillful at your reading, then you can catch up on your listening. Since you have lots of inputs in your mind, you can easily guess what the speaker is going to say. This never means that you should not practice listening. For listening you can listen to cartoons or some movies that are specially made for children. Their languages are easy. Or if you are good at listening you can listen to VOA or BBC programs every day. Again the thing to remember is being active in listening and preferably taking some notes. If you follow these pieces of advice, your speaking and writing will improve automatically, and you can be sure that with a little effort they will become perfect.

A: According to the author, which should you improve first among the four skills?
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Q: Noisia, stylized as NOISI ('VISION' rotated 180), is a Dutch electronic music trio consisting of members Nik Roos, Martijn van Sonderen and Thijs de Vlieger from Groningen, Netherlands.

A: Which was the country for Noisia?
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Q: Osteoporosis and several other bone disorders occur when there is an imbalance between the resorption and formation components of bone remodeling activity. Therapies available for some of these conditions modulate the activity of osteoclasts and/or osteoblasts. The recent discoveries of receptor activator of NF-kappaB ligand (RANKL), an endogenous activator of osteoclastogenenesis and osteoclast activity and its inhibitor, osteoprotegerin (OPG) as pivotal regulatory factors in the pathogenesis of bone diseases like osteoporosis provide unique targets for therapeutic agents. In laboratory animals and now in humans, administering forms of OPG markedly inhibits osteoclast activity and improves bone strength, documenting that the strategy of inhibiting RANKL activity has therapeutic promise. A highly specific, fully human antibody against RANKL has been produced (denosumab) that in early studies in humans reduces bone turnover and improves bone density. Attributes of denosumab in these clinical studies include a very rapid onset of action, sustained effects for several months after a single injection, and good tolerability. These results provide the basis for studies evaluating the effectiveness of denosumab in several clinical conditions characterized by increased osteoclastic activity.

A:
To the ligand of which receptors does Denosumab (Prolia) bind?
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