instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
The Patriots travelled to the Metrodome for a Monday Night Football showdown with the Minnesota Vikings, who, like the Patriots, boasted an excellent run defense. The Patriots, who took to the air with a spread offense for the entire game, opened with a seven-play, 86-yard strike that ended with a touchdown pass from Brady to wide receiver Reche Caldwell. Their next drive was for 93 yards which resulted in a 23-yard Gostkowski field goal. And just before halftime the Patriots moved 74 yards in 11 plays to take a 17-0 lead on a nine-yard scoring toss to tight end Benjamin Watson. The only Vikings score of the game came on a 71-yard punt return by Mewelde Moore in the third quarter; Laurence Maroney immediately answered on the ensuing kickoff, with a 77-yard return to Minnesota's 21-yard line, his second return of over 70 yards in as many weeks. The Patriots' lead grew to 17 after a seven-yard touchdown reception by Brown with 9:03 in the third quarter and then became 31-7 with a touchdown catch by Jackson. The Patriots defense also intercepted four passes from quarterbacks Brad Johnson and Brooks Bollinger. On Bollinger's first drive after relieving Brad Johnson he was sacked three times in a row for a net loss of 23 yards. With their fourth straight victory, the Patriots advanced to 6-1.This was the Patriots' third and final game played in the Metrodome.
answer:
Which team scored more touchdowns, the Patriots or the Vikings?


question:
Change in gene expression associated with pancreatic cancer could be attributed to the variation in histone posttranslational modifications leading to subsequent remodeling of the chromatin template during transcription. However, the interconnected network of molecules involved in regulating such processes remains elusive. hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic potential. Our study explores the possibility that regulation of histone methylation by hPaf1 can contribute towards alteration in gene expression by nucleosomal rearrangement. Here, we show that knockdown of hPaf1/PD2 leads to decreased di- and tri-methylation at histone H3 lysine 4 residues in pancreatic cancer cells. Interestingly, hPaf1/PD2 colocalizes with MLL1 (Mixed Lineage Leukemia 1), a histone methyltransferase that methylates H3K4 residues. Also, a reduction in hPaf1 level resulted in reduced MLL1 expression and a corresponding decrease in the level of CHD1 (Chromohelicase DNA-binding protein 1), an ATPase dependent chromatin remodeling enzyme that specifically binds to H3K4 di and trimethyl marks. hPaf1/PD2 was also found to interact and colocalize with CHD1 in both cytoplasmic and nuclear extracts of pancreatic cancer cells. Further, reduced level of CHD1 localization in the nucleus in hPaf1/PD2 Knockdown cells could be rescued by ectopic expression of hPaf1/PD2. Micrococcal nuclease digestion showed an altered chromatin structure in hPaf1/PD2-KD cells. Overall, our results suggest that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells.
answer:
Which is the histone residue methylated by MLL1?


question:
Almost all earthquakes occur at plate boundaries. All types of plate boundaries have earthquakes. Convection within the Earth causes the plates to move. As the plates move, stresses build. When the stresses build too much, the rocks break. The break releases the energy that was stored in the rocks. The sudden release of energy creates an earthquake. During an earthquake the rocks usually move several centimeters or rarely as much as a few meters. Elastic rebound theory describes how earthquakes occur (Figure 7.21). Where an earthquake takes place is described by its focus and epicenter. The point where the rock ruptures is the earthquakes focus. The focus is below the Earths surface. A shallow earthquake has a focus less than 70 kilometers (45 miles). An intermediate-focus earthquake has a focus between 70 and 300 kilometers (45 to 200 miles). A deep-focus earthquake is greater than 300 kilometers (200 miles). About 75% of earthquakes have a focus in the top 10 to 15 kilometers (6 to 9 miles) of the crust. Shallow earthquakes cause the most damage. This is because the focus is near the Earths surface, where people live. The area just above the focus, on the land surface, is the earthquakes epicenter (Figure 7.22). The towns or cities near the epicenter will be strongly affected by the earthquake. Nearly 95% of all earthquakes take place along one of the three types of plate boundaries. As you learned in the Plate Tectonics chapter, scientists use the location of earthquakes to draw plate boundaries. The region around the Pacific Ocean is called the Pacific Ring of Fire. This is due to the volcanoes that line the region. The area also has the most earthquakes. About 80% of all earthquakes strike this area. The Pacific Ring of Fire is caused by the convergent and transform plate boundaries that line the Pacific Ocean basin. About 15% of all earthquakes take place in the Mediterranean-Asiatic belt. The convergent plate boundaries in the region are shrinking the Mediterranean Sea. The convergence is also causing the Himalayas to grow. The remaining 5% of earthquakes are scattered around the other plate boundaries. A few earthquakes take place in the middle of a plate, away from plate boundaries. Transform plate boundaries produce enormous and deadly earthquakes. These quakes at transform faults have shallow focus. This is because the plates slide past each other without moving up or down. The largest earthquake on the San Andreas Fault occurred in 1906 in San Francisco. Other significant earthquakes in California include the 1989 Loma Prieta earthquake near Santa Cruz (Figure 7.23) and the 1994 Northridge earthquake near Los Angeles. There are many other faults spreading off the San Andreas, which produce around 10,000 earthquakes a year (Figure Convergent plate boundaries also produce strong, deadly earthquakes. Earthquakes mark the motions of colliding plates and the locations where plates plunge into the mantle. These earthquakes can be shallow, intermediate or deep focus. The Philippine plate and the Pacific plate subduct beneath Japan, creating as many as 1,500 earthquakes every year. In March 2011, the 9.0 magnitude Tohoku earthquake struck off of northeastern Japan. Damage from the quake was severe. More severe was the damage from the tsunami generated by the quake (Figure 7.25). In all, 25,000 people were known dead or missing. The Cascades Volcanoes line the Pacific Northwest of the United States. Here, the Juan de Fuca plate subducts beneath the North American plate. The Cascades volcanoes are active and include Mount Saint Helens. Major earthquakes occur here approximately every 300 to 600 years. The last was in 1700. Its magnitude was between 8.7 and 9.2. It has now been more than 300 years since that earthquake. The next massive earthquake could strike the Pacific Northwest at any time. The collision of two continents also creates massive earthquakes. Many earthquakes happen in the region in and around the Himalayan Mountains. The 2001 Gujarat, India earthquake is responsible for about 20,000 deaths, with many more people injured or made homeless. Earthquakes also occur at divergent plate boundaries. At mid-ocean ridges, these earthquakes tend to be small and shallow focus because the
answer:

ground movement caused by the sudden release of energy stored in rocks


