Given an abstract, indicate which of the provided candidate titles (Option1 and Option2) best describes it (respond with the text of the title, not option1/2).
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Question: Abstract: We examined the mechanism underlying the rapid (15-120 min) glucocorticoid-mediated increase in the synthesis of proteins envisioned as mediators of the initial steroid effects in thymic lymphocytes. Analysis of about 1500 in vitro translation products on giant two-dimensional gels revealed rapid hormonal influences on only 7 mRNAs, 6 whose translation products have mol wt and pIs identical to those proteins whose synthesis has been found to be increased after the addition of glucocorticoids to thymus cells. The additional mRNA codes for glucocortin, whose induction in thymus as well as other target cells has been reported. mRNA inductions for proteins 1, 2, and 1N are detectable 15-30 min after the addition of dexamethasone to isolated thymus cells and continue to increase until 2 h, whereas the mRNAs for proteins 4 and 5 are not increased until after 1 h. The mRNA for protein 3 is elevated by 1 h, but attempts to quantitate the change at earlier times have failed because this protein focuses poorly. The parallel between these in vitro translation results and the increased synthesis of individual proteins seen in whole cells demonstrates that increased mRNA levels underlie the cellular changes. Other hormones, such as estradiol, testosterone, and T3, at 10(-6) M and deoxycorticosterone at 10(-8) M do not induce these messages. Partial inductions of 1 and 2, but not 1N, are seen with deoxycorticosterone at 10(-6) M, consistent with its classification as a partial glucocorticoid agonist. Cycloheximide does not block the rise in mRNA for the most rapid inductions, 1, 2, and 1N. The results indicate that dexamethasone rapidly and specifically induces 6 thymus cell mRNAs in addition to the one coding for glucocortin. The cycloheximide results suggest that at least 3 of these represent primary steroid hormone responses. 
 Which is the apt title for the abstract? option1: Glucocorticoid-induced messenger ribonucleic acids in rat thymic lymphocytes: rapid primary effects specific for glucocorticoids. option2: Extensibility of the lumbar and sacral cord. Pathophysiology of the tethered spinal cord in cats.

Answer: Glucocorticoid-induced messenger ribonucleic acids in rat thymic lymphocytes: rapid primary effects specific for glucocorticoids.


Question: Abstract: We evaluated lung function in 20 infants with bronchopulmonary dysplasia (BPD) during the first year of life. Compared with a group of age- and size-matched controls, the infants with BPD had a significantly (P less than 0.005) lower functional residual capacity (FRC; 25 +/- 4 vs 18 +/- 6 ml/kg) at less than 10 1/2 months after conception, but no significant difference during the remainder of the first year. The partial expiratory flow volume curves in the infants with BPD were markedly concave, with tidal breathing approaching expiratory flow limitation. The infants with BPD had significantly (P less than 0.01) lower absolute and size-corrected flows than did control infants, and 50% of the infants with BPD required rehospitalization because of acute respiratory distress associated with a lower respiratory tract illness. In addition, the slope of the linear regression of maximal expiratory flow at FRC (in milliliters per second) vs length (in centimeters) was significantly lower (P less than 0.001) for the infants with BPD than for normal control infants (2.25 vs 4.52), indicating poor growth of the airways. Oxygen saturation (SaO2 was negatively correlated with maximal expiratory flow at FRC, indicating that measurement of SaO2 alone may not be sufficient in the evaluation of lung function in infants with BPD. We conclude that, although infants with BPD improve clinically during the first year of life, they have abnormal functional airway growth; the decreased expiratory flow reserve helps to explain their high risk for acute respiratory distress during lower respiratory tract illness. 
 Which is the apt title for the abstract? option1: Expiratory flow limitation in infants with bronchopulmonary dysplasia. option2: Fetal adenoma of the pigmented ciliary epithelium associated with persistent hyperplastic primary vitreous.

Answer: Expiratory flow limitation in infants with bronchopulmonary dysplasia.


Question: Abstract: The clinical, radiographic and histologic features of sixty-one popliteal aneurysms in 36 patients are reviewed. Twenty-seven aneurysms were thrombosed and presented with an acutely ischaemic limb or the sudden onset of severe claudication. Thirty-four patent aneurysms presented with either ischaemic ulceration or claudication due to tibial artery disease or were asymptomatic with normal distal pulses. Thrombosis made reconstruction difficult and at times required a femoro-tibial graft. In others reconstruction was not possible leading to amputation either as primary treatment or following failed revascularization. In patent aneurysms one or more tibial arteries were frequently occluded. It is postulated that obliterative atheromatous disease of the tibial vessels and the slow flow through the aneurysmal vessels is responsible for the high incidence of thrombosis, poor graft patency and a high amputation rate. 
 Which is the apt title for the abstract? option1: The significance of tibial artery disease in the management of popliteal aneurysms. option2: Medical software regulation: why now? [editorial]

Answer:
The significance of tibial artery disease in the management of popliteal aneurysms.


