Given the task definition and input, reply with output. In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.

 DESIGN : Activating protein - 1 ( AP - 1 ) and Tat - induced transcription were assessed using Jun and hybrid Tat / Jun - expression plasmids and reporter gene constructs which contained AP - 1 binding sites upstream of the rat prolactin TATAA element or an HIV - 1 LTR construct in which AP - 1 binding sites replaced the TAR element .

AP - 1