Given an abstract, and a few options, indicate if any of the given options appropriately describe the given abstract. If any of them is a proper keyword, answer 'Yes', otherwise answer 'No'.
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Question: Abstract: Cell cultures of human keratinocytes contain membrane-associated thioredoxin reductase that is extremely active in reducing radicals on the outer plasma membrane. This enzyme activity was confirmed by its purification from cultures of stratified human keratinocytes by affinity column chromatography. The enzyme was assayed both in vivo and in vitro using a spin-labeled quaternary ammonium compound as the substrate, under saturating conditions in free radical substrate. Specific activities were determined by monitoring the sequential decrease in the amplitude of the electron spin resonance signal per unit of cell protein. The following properties were found: Cultures of adult stratified cells have approximately twice the thioredoxin reductase activity of neonatal cells. The enzyme is inhibited by thioprotein inhibitors (i.e., parachloromecuribenzoate and dinitrochlorobenzene). The activity is regulated by calcium concentrations of the cell culture medium. Stratified keratinocytes are half as active in medium containing 2 mM Ca++ compared with 0.1 mM Ca++ concentration. Product inhibition of the enzyme occurs with oxidized coenzyme NADP+ (i.e., 87% inhibition of enzyme activity over 30 min). The enzyme is heat stable at temperatures of 70 degrees C for 10 min. It is inactivated at 75 degrees C. A comparative study of thioredoxin reductase activity on stratified differentiated and undifferentiated rapidly growing cells was performed. Also, enzyme activity was quantitated for cultured keratinocytes isolated from vitiliginous and normal skin of the same donor. The results of this study, and the connection between this enzyme activity and UV-generated free radicals are reconciled in terms of the mechanism of action and metabolic activity of thioredoxin reductase. 
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Carrier Proteins 2)Olfactory Mucosa 3)Receptors, Sensory

Answer: No


Question: Abstract: In patients with primary pulmonary hypertension, competition between the right and left ventricles for the limited pericardial space results in distortion of left ventricular geometry reflected in displacement of the ventricular septum toward the left ventricular cavity. Left ventricular shape is most dramatically deranged at end-systole and early diastole, suggesting the possibility that the distribution of left ventricular diastolic filling might be altered. To investigate this hypothesis, nine patients with primary pulmonary hypertension and nine normal individuals were studied with echocardiographic techniques. Left ventricular isovolumic relaxation time was significantly prolonged in patients with primary pulmonary hypertension by comparison with normal individuals (129 +/- 36 versus 53 +/- 9 ms, p less than 0.005) and the fraction of the transmitral flow velocity integral occurring in the first half of diastole was significantly less than in normal individuals (38 +/- 14% versus 70 +/- 9%, p less than 0.005). Measurement of fractional changes in short-axis left ventricular cavity area similarly demonstrated that in patients with primary pulmonary hypertension fractional early diastolic cavity expansion (32 +/- 11%) was significantly less than in normal individuals (78 +/- 9%, p less than 0.005). In patients with primary pulmonary hypertension, the ventricular septum was abnormally flattened toward the left ventricular cavity at end-systole (normalized septal curvature 0.04 +/- 0.19) and remained that way throughout early diastolic filling but returned toward normal at end-diastole (normalized septal curvature 0.68 +/- 0.19, p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS) 
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Adolescence 2)Adult 3)Angioma, Sclerosing

Answer: No


Question: Abstract: The prognostic value of marrow chromosome findings was examined in 242 patients with preleukemic myelodysplastic syndromes (MDS) or myeloproliferative disorders (MPD), with emphasis on the significance of single versus multiple karyotypic changes. In both groups, the results showed that patients with multiple chromosome abnormalities in a marrow clone had a very high probability of early death, from progression to leukemia or from other complications of hematopoietic dysfunction. Conversely, in patients with a hemic clone having only one karyotypic alteration (involving a single chromosome or single translocation), survival over 2 years was only slightly reduced as compared to those without chromosome abnormality. The only single karyotypic alteration perhaps associated with a markedly shortened survival was monosomy 7. These findings suggest that the conclusions of previous studies concerning the grave consequences of chromosome alterations in preleukemia largely reflect the clinical significance of clones with multiple cytogenetic changes. Prior knowledge of the karyotypic status of preleukemic patients should be helpful in evaluating current attempts to find effective treatment for these difficult disorders. 
Question Does the following mesh terms have a suitable mesh term for the abstract? 1)Aged 2)Bone Marrow 3)Chromosome Aberrations 4)Female 5)Human 6)Male 7)Middle Age 8)Myeloproliferative Disorders 9)Preleukemia 10)Prognosis 11)Support, U.S. Gov't, P.H.S..

Answer:
Yes


