ERBB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors.

Application

Applications:

Immunohistochemistry (IHC)

Western Blot (WB)

Application notes:

IHC: 1:50-1:100, WB: 1:500-1:1000

Conjugation type:

Unconjugated

Research area:

Cytokine

Growth Factor

Immunogen:

ERBB3 antibody was raised in Rabbit using the peptide sequence around aa 1326~1330 (P-D-Y-W-H) derived from Human Her3/ErbB3 as the immunogen.