Neonatal lupus syndrome can develop in the unborn children of women whose immune systems produce two antibodies-called anti-Ro and anti-La-which react against two proteins found in the cells of all individuals.

To examine the effect of prenatal high-dose steroids on the T-cell component of the immune system, he and his coinvestigators studied eight children with a history of such therapy given after they were diagnosed in utero with neonatal lupus.

NEW YORK -- Exposure to maternal lupus autoantibodies confers a risk of congenital heart block and neonatal lupus on the fetus, but the risk is small, and no medical treatment is currently recommended, Jill P.

These antibodies are found in ~60% of patients with Sjogren syndrome, in ~30% of patients with systemic lupus erythematosus, in a majority of patients with sub-acute cutaneous lupus, and in the neonatal lupus syndrome (1,2).

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