[The selective inhibition of cyclooxygenase isoforms: a new approach to the search for effective and safe nonsteroidal anti-inflammatory drug agents].
The author submits present-day data on mechanisms of action and clinical application of new drug preparations, NSAID, derivatives of enolic acid of the oxicam class, movalis, as one of their number (meloxicam, international name), of Boehringer Ingelheim (Germany). Clinical and pharmacological value is discussed of selective blockade of cyclogenase isoenzymes (COX)--COX1 and COX2 in the antiinflammatory effect and development of unfavourable side-effects.