Higher dissolution rates of diazepam were noted with tablets containing the drug in polyethyleneglycol solid dispersion compared to these containing a physical mixture of the drug granulated with polyethyleneglycol or to directly compressed tablets. The shape factor and t63% depend strongly on the method of incorporation of the drug in the compressed mass. The dissolution of the drug becomes pH independent when it is present as a solid dispersion, which may be advantageous for the bioavailability.
Chemistry, Pharmaceutical Drug Compounding