After peripheral injections of the electrochemically active drug acetaminophen, striatal levels of the drug were measured in 3 different ways: in vivo electrochemistry, in vivo dialysis, and tissue assay. The time course of the acetaminophen concentrations measured by in vivo dialysis paralleled the in vivo electrochemistry curve and lagged behind the peak tissue concentration. This result suggests that dialysis and electrochemistry provide equivalent measurements of extracellular fluid acetaminophen. In vitro, dialysis recovery of acetaminophen was 28% of the beaker concentration.
Acetaminophen Animals