We have isolated a rat cDNA and a novel gene, Reg (regeneration-promoting gene). The cDNA encodes a 174-amino-acid (aa) RegIII protein with a 25-aa signal peptide. The RegIII gene spans 2.7 kb and consists of six exons and five introns. RegIII was expressed in regenerating pancreatic islets, but not in normal islets.
Amino Acid Sequence Animals