Extensive immunochemical characterization has shown that the free beta subunit of hCG (betahCG) can be produced by common epithelial tumors, including lung, colon, and bladder. However, the expression of beta-human chorionic gonadotropin (hCG) in hematologic malignancies and its significance is largely unknown. We present an extremely rare case of positive serum betahCG in a postmenopausal woman with relapsed, refractory multiple myeloma with myeloma cells expressing betahCG on immunohistochemical stain.
Antineoplastic Agents Chorionic Gonadotropin, beta Subunit, Human