Methyl N-butyl ketone (MNBK) inhibited the activity of mouse liver alcohol dehydrogenase (LADH) in vitro. Ethanol elimination was reduced in MNBK-treated mice as compared to controls. Ethanol-induced induced loss of righting reflex was significantly prolonged in mice pretreated with MNBK.
Alcohol Dehydrogenase Alcohol Oxidoreductases