The present study investigates antimutagenic and anticytotoxic effect of polyvitamin complex Polijen in laboratory mice. Mutation in mice was induced by pesticide - copper oxychloride 3Cu(OH)2 CuCl2 , which is characterizes by the mutagenic and cytotoxic effect. Introduction of copper oxychloride (dosage 1/2, 1/5, 1/10 LD50) per oral to animals induces strong increase (p<0,001) of frequency of chromosomal aberrations (multiple fragments, lyses), genomic mutations (triploidy, tetraploidy), pathological mitosis (hollow metaphase, K-mitosis, adhesion of chromosomes) and destruction of interphase nucleuses (hollow nucleus). Experiments showed that administration of polyvitamin complex Polijen decreased 2, 5 times mutagenic and cytotoxic effect of pesticide-copper oxychloride.
Animals Chromosome Aberrations