Luteinizing hormone-releasing factor (LRF)-like immunoreactivity was demonstrated by a three-layer immunoperoxidase method in the islet cells of human pancreas and in the neoplastic cells of insulomas. Adenocarcinomas originating in the exocrine pancreas were LRF-negative. The results demonstrate another hypothalamic peptide-like material in the gastrointestinal tract, the biological role of which remains to be clarified.
Adenocarcinoma Adenoma, Islet Cell