Rehabilitative treatment with the beta-blocker anaprilin was performed in 58 patients with coronary heart disease within early periods (on days 7 to 21) after aortocoronary bypass surgery. Group 1 patients were given oral anaprilin. Group 2 patients took the drug by sinusoidal modulated current electrophoresis. With the latter drug administration, its negative chronotropic effect and abolished adverse decrease in myocardial contractivity were detected in the patients from that group. Bearing in mind the results of pharmacokinetic studies, it was suggested that the therapeutic effect of small blood anaprilin concentrations was due to the electrophoresis-induced passage of only its therapeutically beneficial left isomer and L-propranolol glucuronide, a metabolite.
Adrenergic beta-Antagonists Adult