In a double-blind trial, children who had recurrent and/or complex febrile convulsions were treated with either phenobarbital sodium or carbamazepine. Forty children were suitable for analysis; 19 were receiving carbamazepine, and 21 were receiving phenobarbital. Of the carbamazepine-treated patients, nine (47%) had recurrent convulsions despite therapeutic levels of the drug, while only two (10%) of the phenobarbital-treated patients suffered further seizures. These results confirm previous findings suggesting that carbamazepine is not as effective in the prophylactic treatment of febrile convulsions as phenobarbital.
Carbamazepine Clinical Trials as Topic