The synthesis and screening of antitumor activity in vitro (cytotoxicity) of various oxygen, nitrogen, sulfur and platinum-containing derivatives of allobetulin, including different arrangements of the double bonds in the A and B rings, penta- and hexacyclic ring A, 21-acetyl-20,28-epoxy-18á,19âH-ursane-isomeric cycle E, was carry out. (3R,5R)-19â,28-Epoxy-4,5-seco-18á-olean-3(5)-ozonide and 2,3-indolo-21â-acetyl-20â,28-epoxy-18á, H-19â-ursane showed significant cytotoxic activity against melanoma MeWo and Leukemia SR cells, appropriately. (3S,5S)-Diastereomer of the first compound showed no cytotoxicity.
Cell Proliferation Drug Screening Assays, Antitumor