Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.
Adolescent Adult