Vinblastine (Vb), a drug belonging to a group of mitotic poisons, was shown to induce sexual chromosome nondisjunction and loss (SCNL) in oogenesis of different strains of Drosophila melanogaster. Heat shock (37 degrees C, 45 min) decreases the frequency of these events. The highest level of nondisjunction was demonstrated in the temperature-sensitive strain both after heat shock and Vb treatment. No increase of SCNL frequency in oocytes of females treated with griseofulvin (Gf) and Colchicine (Cl), analogues of Vb.
Animals Colchicine