The therapy with (modified) immune serum globulin implies critical limitation of therapeutic indications as well as the knowledge of the biological and physical properties of the immunoglobulin preparations. While the therapeutic effect in prophylaxis and substitution therapy is well established, the benefit has still to be proven for the therapy of severe acute infections. The predominant role of antibodies in the defense against bacterial and some viral infections encourages for the use of immune serum globulin in acute infections.
Antibody Formation Antigen-Antibody Complex