Anaphylactic reactions to protamine administration often can be predicted by the presence of patient risk factors. In the case described, an anaphylactic reaction to protamine occurred in a patient without identifiable risk factors. A history of prior protamine exposure, fish allergy, or vasectomy suggests patients may be at greater risk for anaphylactic response to protamine; however, patients can develop anaphylaxis in the absence of such factors.
Anaphylaxis Anesthesia