The authors studied the content of lactic acid in glial tumors of the brain and brain tissue of rats in short-term artificial hyperglycemia. In short-term artificial glycemia the lactic acid content in glial tumors of animals was almost twice the level of this metabolite in the brain tissue, which is due to the high potential rate of glucose consumption by the tumor and the increased glycolytic activity in it in these conditions. The lactate content in the glial brain tumors significantly increases when the sugar concentration in the blood of animals is artificially increased. It is suggested that accumulation of lactic acid in brain gliomas of experimental animals contributes to diminution of tumor cell viability, which will increase sensitivity of the tumor to irradiation.
Animals Astrocytoma