Several á-alkylated â-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic á-alkyl-â-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic â-keto esters high to excellent inductions were obtained.
Amino Acids Catalysis