The TMTD does not change the secretory activity of the dogs' stomach with its one-time administration by mouth in doses of 0.5--10 mg/kg. With its multiple introduction (10 mg per kg once a day for a space of consecutive 30 days) the secretion of juice increases, while the pepsin content in the juice of dags diminishes. The DEDCS, EEDMDCA, TMTD and EBDCC (singly into the stomach in a dose of 1l5LD50 per kg) bring down the glycogen-forming and secretory function of the liver in rats and inhibit the propulsive activity of the intestines in mice, stimulated with 5-oxytryptophan. The mechanism of the intestinal motor activity inhibition is caused by the inhibition of oxytryptophandecarboxylase (CP 4.1.1.28) in the intestines of the animals with the DTCA derivatives.
Animals Digestive System