The study was designed to investigate some central effects of chiral xanthone derivatives [(R,S)-2-N-(6-chloro-2-xanthonemethyl)-amino-1-propanol - MH-31, R enantiomer - MH-32 and S enantiomer - MH-33] in mice. The effects of these chiral compounds were examined in picrotoxin-induced seizures, spontaneous locomotor activity and chimney tests. The tested compounds demonstrated variable influence on the central nervous system in mice. The compound MH-32 exhibits anticonvulsant activity in picrotoxin-induced seizures, whereas MH-31 and its R enantiomer--compound MH-32 demonstrated antidepressant-like activity in the forced swimming test. Moreover, all tested xanthones reduced the locomotor activity in mice. The obtained results indicate the importance to examine pharmacologically enantiomers rather than only racemic mixtures of newly synthesized compounds.
Animals Anticonvulsants