A comparative analysis of primary sequences of the region of "leaving group" of a number of splittings evoked by serine proteinases under the activation of protein-precursors has been carried out. A pronounced domination of amino acids of hydrophobic nature in P2'-position similar to that observed in case of the reactive centres of serpines has been noticed. Physiological role of S2'-stimulation of serine proteinases is discussed.
Amino Acid Sequence Amino Acids