Factor VIII molecular complex is included in the proteins of "acute inflammation", being changed not only in the congenital diseases - hemophilia A and Willebrand disease but also in a series of acquired diseases as various inflammatory processes, hypercoagulability, DIC syndrome, neoplasms. The studies carried out on Hodgkin's disease and non-Hodgkin lymphomas reveal that the changes in its separate activities (factor VIIIK and Willebrand antigen) are not unidirectional with the changes of fibrinogen level and cannot serve as an index of the activity of the process.
Factor VIII Fibrinogen