OBJECTIVE: To investigate the effect of intravenous itraconazole on fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation.METHODS: Seventy-five such patients treated with itraconazole from October, 2002 to October, 2005 were studied. The diagnosis of fungal infection was made according to the criteria recommended by Chinese workshop on invasive fungal infection (IFI). Four patients were definitely diagnosed as IFI, twenty-two patients probably and 49 patients possibly.RESULTS: Fifty-seven of the 75 patients showed response to itraconazole therapy including 3 definite, 18 probable and 36 possible cases.CONCLUSION: Fungal infections in patients undergoing allogeneic stem cell transplantation diagnosed according to the criteria recommended by Chinese workshop on IFI can be successfully treated with itraconazole.
Adolescent Adult