In an in vitro study with rat liver, ammonium meta vanadate (NH4VO3) was found to inhibit microsomal ketamine N-demethylation, lipid peroxidation, and hydrogen peroxide formation; to have no effects on 4-methylaminoantipyrine N-demethylation and on glucuronyltransferase I activity, and to enhance glucuronyltransferase II. Mitochondrial succinate dehydrogenase and cytochrome c reductase were inhibited but cytochrome oxidase activity was enhanced by ammonium vanadate. Ammonium meta vanadate increased malate dehydrogenase activity but had no effect on glutamate, lactate, glycerophosphate, isocitrate, glucose-6-phosphate, and 6-phosphogluconate dehydrogenases.
Animals Cytosol