A principle possibility for transplantation of the midbrain areas of the human embryos into the brain of mature rats has been demonstrated. For successful xeno-transplantations the midbrain of 7-8-week-old embryos is the most suitable. The intracerebral transplants grow predominantly along the capsule of the white substance fasciculi. Cell differentiation of the intraventricular transplants in comparison with the intramedullary ones takes less time. Manifestation of the glial scar at the borders of the transplant depends on its localization. Perspectives on applying the method of the nervous embryonal tissue transplantation into the brain of mature animals for reconstruction and formation of new centers in order to compensate cerebral defects are discussed.
Animals Cell Differentiation