The innate immune response is an important host primary defense system against pathogens. ã-Oryzanol is one of the nutritionally important phytoceutical components in rice bran oil. The goal of this study was to investigate the effect of ã-oryzanol-rich extract from black rice bran (ãORE) on the activation of the innate immune system. In this study, we show that ãORE increased the expression of CD14 and Toll-like receptor 4 and enhanced the phagocytic activity of RAW264.7 macrophages. Furthermore, ãORE and its active ingredient ã-oryzanol promoted the secretion of innate cytokines, interleukin-8, and CCL2, which facilitate phagocytosis by RAW264.7 cells. These findings suggest that ã-oryzanol in the ãORE enhances innate immune responses.
Animals Chemokine CCL2