Motivation: We have developed geneAttribution, an R package that assigns candidate causal gene(s) to a risk variant identified by a genetic association study such as a GWAS. The method combines user-supplied functional annotation such as expression quantitative trait loci (eQTL) or Hi-C genome conformation data and reports the most likely candidate genes. In the absence of annotation data, geneAttribution relies on the distances between the genes and the input variant.Availability and Implementation: The package is freely available from http://www.bioconductor.org/ . A quick-start vignette is included with the package.Contact: wustera@gene.com.
Genetic Association Studies Genome, Human