In chronic experiments on dogs, the heterogenic effect of serotoninergic structures of the upper and lower parts of the limbic cortex's anterior area was revealed in respect to the heart rate and respiration. Administration of 0.2 mg of serotonin-adipinate (through chemotrodes, bilaterally, in 0.02 ml of saline) into the upper part induced deceleration of the heart rate and respiration whereas the contrary effect occurred after the administration into the lower part. Administration of saline exerted no effect and the i. m. administration of serotonin-adipinate and 5-oxytryptophane (0.5 mg/kg) exerted either no effect as well or a short-lasting one.
5-Hydroxytryptophan Adipates