PURPOSE: To report the occurrence of monolateral central retinal vein occlusion in a patient with heterozygous 20210 G/A prothrombin genotype, known to be associated with high thrombophilic risk.METHODS: A monolateral central retinal vein occlusion was diagnosed in a 71-year-old woman, who had suffered from a deep vein thrombosis in her left leg at the age of 36 years. Mutations of the genes involved in the coagulation process were investigated by DNA polymerase chain reaction.RESULT: DNA analysis showed the patient to be heterozygous for the prothrombin 20210 G/A genetic variation.CONCLUSION: The 20210 G/A prothrombin gene mutation may be associated with central retinal vein occlusion.
Aged DNA