The study of the factors relevant to the bile colloid stability in aggravation of calculous or ++non-calculous cholecystitis demonstrated changes in aggregative-kinetic stability of bile presenting with low boundary of the phase transition, electrokinetic potential, mass and growing size of macromolecular compounds. This is much coupled with high bile levels of protein, calcium and iron which exhibited mutually potentiating effect. At the same time, hydrolysis of protein-containing bile components +determined by the increment of amine and sulfhydryl groups evidences for colloid destabilizing active role of calcium and iron. In view of this finding elevated concentration of iron and calcium in exacerbations of cholecystitis may have both diagnostic significance and be indicator of the role of inflammation in lithogenesis.
Bile Cholecystitis