Substitution of regular partial reinforcement for random one (in both cases the reinforcement frequency was 50%) acted in some dogs as a neurotizing factor: they showed unrest, stable defensive reflexes disappeared, corresponding changes were observed in vegetative reactions. At the same time activation of the sympatho-adrenal system was recorded along with a drop in concentration of acetylcholine in peripheric blood. It is noted that the development of neurotic disturbances in dogs in these conditions were to a certain degree dependent of the dominating motivation.
Acetylcholine Animals