UNLABELLED: Medical abortion means interruption of early pregnancy (usually before 9-th gestational week) as a result of administration of abortifacient drugs without surgical intervention.OBJECTIVE: To investigate the efficacy and tolerability of methotrexate plus misoprostol regimen as a method for early medical abortion < 49 days L.M.P.MATERIAL AND METHOD: 50 mg methotrexate was administered orally to 20 women < 49 days L.M.P. followed by 800 mcg misoprostol vaginal and oral administration 3-7 days after the methotrexate.RESULTS: 19 Successful medical abortions (95%). One woman chose vacuum aspiration for termination of the abortion on day 3 of the induced bleeding. No serious side effects were observed after administration of the drugs.CONCLUSION: Medical abortion with methotrexate and misoprostol is safe and effective and can be offered to practicing gynecologists.
Abortifacient Agents, Nonsteroidal Abortion, Induced