Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO(2) release profiles with half-lives of SO(2) release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 ìM) of inhibiting  Mycobacterium tuberculosis  (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 ìM).
Antitubercular Agents Cell Survival