PURPOSE: To investigate the properties of HYPR (HighlY constrained back PRojection) processing-the temporal fidelity and the improvements of spatial/temporal resolution-for contrast-enhanced MR angiography in a pilot study of the lower extremities in healthy volunteers.MATERIALS AND METHODS: HYPR processing with a radial three-dimensional (3D) stack-of-stars acquisition was investigated for contrast-enhanced MR angiography of the lower extremities in 15 healthy volunteers. HYPR images were compared with control images acquired using a fast, multiphase, 2D Cartesian method to verify the temporal fidelity of HYPR. HYPR protocols were developed for achieving either a high frame update rate or a minimal slice thickness by adjusting the acquisition parameters. HYPR images were compared with images obtained using 3D TRICKS, a widely used protocol in dynamic 3D MRA.RESULTS: HYPR images showed good temporal agreement with 2D control images. In comparison with TRICKS, HYPR stack-of-stars demonstrated higher spatial and temporal resolution. High radial undersampling factors for each time frame were permitted, typically approximately 50 to 100 compared with fully sampled radial imaging.CONCLUSION: In this feasibility study, HYPR processing has been demonstrated to improve the spatial or temporal resolution in peripheral CE-MRA.
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