Modulation of ã-secretase activity is a promising therapeutic strategy for the treatment of Alzheimer's disease. Herein we report on the synthesis of carprofen- and tocopherol-derived small-molecule modulators carrying terpene moieties as lipophilic membrane anchors. Additionally, these modulators are equipped with an acidic moiety, which contributes to the desired modulatory effect on the ã-secretase with decreased formation of Aâ42 and increased Aâ38 production.
Amyloid Precursor Protein Secretases Animals