OBJECTIVE: The decomposition of Ginsenoside Rg1(Rg1) by intestinal bacteria in rats or human was investigated both in vitro and in vivo.METHOD: The decompositions were investigated by means of thin-layer chromatography and Electron spurt ion mass.RESULT: It was found that Rg1 was converted into two metabolites [Rh1 and 20(S)-protopanaxatriol(20S-Ppt)] by human intestinal bacteria in vitro, while three compounds [Rh1, F1, and 20(S)-Ppt] were detected in rat intestinal bacteria metabolism in vitro and in vivo.CONCLUSION: The decomposition and/or metabolism of Rg1 in rat and human digestive tract was confirmed. The mode of metabolism in rat is Rg1-->Rh1(F1)-->Ppt, while in human it is Rg1-->Rh1-->Ppt.
Animals Bacterial Physiological Phenomena