BACKGROUND: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is associated with dyspnoea and, consequently, reduced mobility. Immobility is a recognised risk factor for deep venous thrombosis (DVT), but few data exist regarding the prevalence of DVT in acute exacerbation of COPD. Real-time B-mode ultrasonography (US) is a noninvasive screening-method for the diagnosis of DVT. We therefore used US to investigate the prevalence of DVT in patients with an acute exacerbation of COPD.METHODS: In a prospective cohort study 196 patients with COPD were studied (110 men, 86 female, age: 66.9 +/- 9.1 years, weight: 63.5 +/- 12.7 kg, forced expiratory volume in 1 second [FEV1]: 0.7 +/- 0.21, FEV1% of vital capacity [VC]: 37 +/- 6) in a respiratory intensive care unit on the day of admission. Patients with reduced mobility due to other diseases were excluded. All US were performed by one experienced person with a 5 MHz linear scanner. The veins of the lower extremity were subdivided into 3 segments: 1. The common femoral, 2. superficial femoral veins including the long saphenous vein and 3. the popliteal vein.RESULTS: In 21 of 196 COPD patients (10.7%) DVT were demonstrated; 18 of these were asymptomatic. Bilateral DVT were not found. In 6 patients additional diagnoses were obtained. There was no difference between patient with and without DVT with respect to age, hemoglobin, PO2, PCO2, pH, FEV1, VC or dyspnoea scale.CONCLUSIONS: DVT in the lower extremity, which was not detectable on clinical examination, was relatively common in patients with an acute exacerbation of COPD. All measured clinical variables (age, weight, dyspnoe-scale, lung function, hemoglobin and hematocrit and blood gases) failed to predict patients more likely to have DVT.
Acute Disease Aged