Myeloperoxidase in the presence of 0.7 mM hydrogen peroxide degrades hyaluronic by a mechanism which involves iron. Degradation is enhanced in the presence of chloride ion, which is attributed to the formation of hypochlorous acid. Myeloperoxidase-dependent degradation of hyaluronic acid is inhibited by superoxide dismutase, desferrioxamine, iodide ion, bromide ion, mannitol, histidine and various antiinflammatory agents. The destructing agent is presumably the hydroxyl radical.
Anti-Inflammatory Agents Enzyme Activation