Experiments with male albino rats gave evidence that a single intraperitoneal injection of 15% ethanol at the doses of 0.28 and 2.25 g/kg resulted in enhanced elimination of biologically active substances by tissue basophils (TB) both due to intensified degranulation and greater number of TB in the thyroid gland. Single total exposure to ionizing radiation at the doses of 5, 10, and 20 Gy stimulated the functional activity of TB with simultaneous accumulation of biologically inactive substances. Radio modifying effect of ethanol with respect to thyroid TB consisted of an increase of their number and a decrease in the extent of degranulation which was not dependent on the sequence of radiation exposure and ethanol injection.
Animals Basophil Degranulation Test