OBJECTIVE: To study the expression of eosinophil in nasal polyposis tissue after Bleomycin A5 local injection.METHOD: Nineteen cases nasal polyposis specimen obtained before and after treatment with Bleomycin A5 were studied with terminal deoxynucleotidyl transferasemediated dUTP nick endlabeling (TUNEL).RESULT: The number of eosinophil in nasal polyposis specimen before treatment is significantly higher than that after treatment (P<0.01) and so to normal inferior turbinate concha mucosa (P<0.01). The apoptosis index (AI) of eosinophil after treatment is significantly higher than that before treatment (P<0.01).CONCLUSION: Eosinophil is the main infiltration cell in nasal polyposis tissue. Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis.
Adult Aged