The effect of various hormones on the levels of poly(A) polymerase in the ventral prostate of castrated rats was investigated. It was observed that this enzyme is specifically induced by androgens; progesterone and estradiol-17 beta did not cause stimulation of poly(A) polymerase activity. Dihydrotestosterone-induced poly(A) polymerase was inhibited by cordycepin, actinomycin-D and cycloheximide, which indicates that the genetic transcription leading to the enzyme poly(A) polymerase is regulated by androgens in the ventral prostate.
Androgens Animals