Chronic administration of imizine to rats irrespective of the administration schedule (once a day in the morning or in the evening in a dose of 10 mg/kg, twice a day in a dose of 5 mg/kg) changed the circadian rhythm of rest-activity with a shift of the acrophase at the late night hours. However at a single administration of the drug the effect occurred earlier than at its administration twice a day.
Animals Circadian Rhythm