Stability of secondary structure was studied in DNA preparations obtained from healthy and leukemic rats and mice of BALB/c strain by means of estimation of molecular melting point temperature, of the temperature-dependent transition interval and specific viscosity. The secondary structure stability and values of the DNA specific viscosity were decreased in the DNA preparations obtained from liver, spleen tissues and tumors of rats with Shvetz leukemia and from spleen of mice infected by Rausher viral leukemia as compared with these patterns of healthy animals. Strain- and tissue-dependent alterations of the patterns studied were not found.
Animals DNA