The results of experiments on cats showed that quaternidine, a quaternary ammonium derivative of trimecaine, does not induce significant variations in the hemodynamic parameters, being advantageous in this respect to some well-known antiarrhythmic drugs. LKhT-3-00 (dialkylaminophenylacetamide glutaminate)--a tertiary derivative of lidocaine--leads to a slight decrease in the heart rate, an insignificant decrease in the arterial pressure for 10 min, and a pronounced enhancement of the pumping ability of the left ventricle over a time period of 30 min.
Animals Anti-Arrhythmia Agents