A parallel study on the content of prostaglandins (PG) in the kidneys, the morphological condition of the medulla interstitial cells, and the activity of prostaglandin-dehydrogenase in rats given indometacyn for 5 days in a dose of 5 mg/kg was carried out. A considerable decrease in the content of PGA2 and PGE2 and an increase in PGF 2alpha in the kidneys of the experimental animals as compared with the controls was noted. The number of lipid granules in the interstitial cells of the renal medulla was also increased. A significant rise in the activity of prostaglandin-dehydrogenase was observed in the kidneys of the animals given indometacyn. The experimental results confirmed the suggestion that the medulla interstitial cells took a direct part in synthesis of renal PG. Indometacyn was shown to be able to decrease the PG content in the kidneys not only by inhibiting the activity of prostaglandin-dehydtogenase, as it was thought, but also by increasing the activity of prostaglandin-dehydrogenase.
Animals Cyclooxygenase Inhibitors