In two coupled cells, each containing a bisubstrate-kinetics reaction system, the two substrates can cross the membranes through gap-junction protein channels (gating). Passing through the gap-junctions is controlled by one of the substrates, thus resulting in non-linear diffusion. Linear stability analysis gives the conditions, under which the symmetric fixpoint becomes unstable, leading to spatial asymmetry (Turing structures). The implications for morphogenesis are discussed.
Animals Biological Transport, Active