A concise synthesis of (2S,5R) and (2S,5S)-5-hydroxy-lysine was achieved by utilizing D-galactose as a chiral-precursor with stereo retention. This synthetic strategy showcased the potential of utilizing carbohydrates as starting materials to prepare amino acids. Using the diazido intermediate, the derived â-D-galactopyranosyl and á-D-glucopyranosyl-(1?2)-â-D-galactosyl moieties were synthesized.
Galactose Hydroxylysine