A radioimmunoassay for human pancreatic chymotrypsin II has been developed. Serum immunoreactive chymotrypsin II content in healthy individuals ranged from 14.7 ng/ml to 77.5 ng/ml, the average being 37.5 ng/ml (SD = 19.6). Elevated values were observed in patients with acute pancreatitis and renal failure. After total pancreatectomy, serum immunoreactive chymotrypsin II was not detectable. A significant positive correlation was observed between serum immunoreactive chymotrypsin II and cationic trypsin contents.
Antibody Specificity Chymotrypsin