The authors have carried out a comparative analysis of the interaction between two types of suture material with blood components, as well as studied the effect of heparin-mediated modification on the sorption and contact-activating processes in the zone of the anastomosis. The blood-compatible properties of the latter was assesses in vitro. It was determined that by minute 120 of the contact with blood, the largest amount of protein is had been absorbed by the anastomoses performed using the Prolene thread - 112 microg/cm2. Heparin-mediated modification made it possible to dramatically decrease the amount of the absorbed proteins. On the anastomoses performed with TiNi, additional treatment with heparin lead to an inconsiderable decrease in the protein amount. When identifying the absorbed proteins, we revealed dependence on the type of the suture material and modification with heparin. After a 60-minute contact with blood in the area of the anastomosis made with TiNi, absorbed were: albumin, immunoglobulins A, G, and transferrin. When using the Prolene thread, fibrinogen was noted to join. Additional heparinization exerted a favourable effect on the sorption processes in the area of the anastomosis wherein predominantly albumin and immunoglobulins A and G are predominantly absorbed. The parameters of the peak values and the rate of blood platelet aggregation were minimal in the area of the anastomoses done with TiNi with an additional treatment with heparin.
Adsorption Anastomosis, Surgical