Primary cutaneous gamma/delta T-cell lymphoma (PCãäTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the ãä heterodimer of the T-cell receptor (TCR). As an entity, PCãäTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes. Herein, we present a rare case of CD8+ PCãäTCL with a discussion highlighting theheterogeneity within this entity.
Aged CD8-Positive T-Lymphocytes