Glimepiridi sitoutuu suuressa määrin proteiineihin (> 99%), ja sen puhdistuma on pieni (noin 48 ml/ min). ###>Glimepiride has a very low distribution volume (approximately 8.8 litres) which is roughly equal to the albumin distribution space, high protein binding (> 99%), and a low clearance (approximately 48 ml/ min).