Lääkitystä ei yleensä tule jatkaa aiemmin kuin 48 tuntia leikkauksen jälkeen. ###>Therefore, due to the metformin active substance, Competact should be discontinued prior to, or at the time of the test and not reinstituted until 48 hours afterwards, and only after renal function has been re-evaluated and found to be normal (see section 4.5).