us stock futures traded mixed this morning here are some big stocks recording losses in today’s premarket trading session   esperion therapeutics inc dropped 503 to 198 in premarket in 8k filing wednesday esperion reported partner daiichi sankyo europe said esperion is not entitled to receive milestone payments based on clear outcomes data in trial of bempedoic acid to treat cholesterol   virgin orbit holdings inc shares dipped 439 to 05670 in premarket trading after cnbc said ‘virgin orbit pauses operations for a week furloughs nearly entire staff as it seeks funding’   liveperson inc shares tumbled 384 to 602 in premarket trading after the company posted downbeat q4 sales and issued weak revenue forecast don’t forget to check out our premarket coverage here   amyris inc declined 177 to 098 in premarket trading after posting a loss for the fourth quarter   proterra inc dipped 163 to 210 in premarket trading after the company posted downbeat q4 results and issued weak fy23 revenue forecast   burford capital limited shares declined 145 to 654 in premarket trading after the company issued an update on its 2022 business activity   first republic bank shares dropped 64 to 2916 in premarket trading bloomberg reported that first republic bank is said to weigh options including a sale citing people with knowledge of the matter   baidu inc fell 52 to 12619 in premarket trading baidu recently launched ai chat app wiseai overseas following release of its ai virtual chat community app xiaokan planet in china   tremor international ltd shares dropped 48 to 538 in premarket trading   amc entertainment holdings inc fell 42 to 136 in premarket trading now read this sp 500 settles lower following economic reports market volatility increases