international stocks trading in new york closed mostly lower on tuesday the spbny mellon index of american depositary receipts edged up 01 to 15749 the european index rose 09 to 15295 the asian index retreated 13 to 18157 the latin american index slipped 01 to 20225 while the emergingmarkets index moved down 12 to 29955 novo nordisk was among those whose adrs traded actively the healthcare company surged 17 after a study showed the companys drug wegovy not only helped people lose weight but also reduced their risk of heart attacks strokes and cardiovascular deaths by 20 james hardie industries rose 15 following the building materials suppliers first quarter results and outlook