corvus pharmaceuticals inc shares were up 77 at 4 in very heavy trade at midday friday volume for the stock was 118 million shares at 1205 pm et compared with its 65day average volume of 297000 shares the stock which has a public float of 295 million shares hit its 52week low of 186 on aug 20 corvus said in august that an ind application submitted by angel pharmaceuticals ltd its partner in china was accepted by the center for drug evaluation of the china national medical products administration the ind was for a phase 11b clinical trial of corvus cpi818 to treat certain lymphomas