international stocks trading in new york closed lower on wednesday the spbny mellon index of american depositary receipts ticked down 05 to 14229 the european index edged down 03 to 13801 the asian index retreated 07 to 16369 the latin american index lost 04 to 18522 while the emergingmarkets index shed 11 to 27799 amarin corp was among those whose adrs traded actively the dublin biopharmaceutical company slipped 17 after it said switzerlands swissmedic has granted approval for amarins fishoilderived drug vazkepa steelmaker arcelormittal sa edged down 06 after itochu corp agreed to buy a 496 stake in a company that holds a 15 stake in a arcelormittal canadian subsidiary