international stocks trading in new york closed mostly higher tuesday the spbny mellon index of american depositary receipts edged up 03 to 12261 the european index gained 06 to 11734 the asian index ticked down 06 to 14041 the latin american index advanced 18 to 18586 while the emergingmarkets index rose 02 to 24545 astrazeneca plc was among those whose adrs traded actively the pharmaceutical giant was down 04 on news of a collaboration agreement with ikena oncology inc to evaluate tagrisso in combination with ikenas ik930 as a treatment for patients with egfrmutated nonsmall cell lung cancer clinicalstage biopharmaceutical company atai life sciences slipped 37 after initiating its phase 1 clinical trial of intranasal inb01 with topline results expected in the first half of 2023