international stocks trading in new york closed mostly lower on wednesday the spbny mellon index of american depositary receipts eased 05 to 15848 the asian index fell 13 to 20175 and the emergingmarkets index fell 11 to 33572 meanwhile the european index edged up 001 to 14507 and the latin american index improved 05 to 19243 harmony gold mining co was among those whose adrs traded actively harmony gold mining co cut its fullyear production guidance after geotechnical issues hurt production from the hidden valley mine in papua new guinea adrs fell 11 to 371 banco santander sa is launching a buy now pay later service making it one of the first traditional banks to enter this growing market as it looks to boost its consumercredit business the spanish lender will begin offering the service zinia to customers in the netherlands this year with other markets to follow it said wednesday adrs closed 23 higher at 352