international stocks trading in new york closed mostly higher on tuesday the spbny mellon index of american depositary receipts increased 04 to 16263 the european index edged up 02 to 14764 and the asian index rose 08 to 21278 meanwhile the latin american index declined 02 to 17852 and the emergingmarkets index eased 004 to 34576 toyota motor corp was among those whose adrs traded actively the centers for disease control and prevention recommended that many children with weakened immune systems get a booster from pfizer inc and biontech se four weeks after their second shot the agency issued the recommendation tuesday for moderately and severely immunocompromised children aged 5 to 11 years it also said that people who received the vaccine from pfizer and partner biontech should receive a booster dose five months after their second shot shortening the timeline by a month the decisions follow the food and drug administrations authorization of both measures on monday biontechs adrs closed down 34 at 22409 novartis ag said tuesday that a us appeals court has upheld the exclusivity of its multiplesclerosis blockbuster drug gilenya with this decision novartis confirms that it expects no generic versions of gilenya in the us market for at least the next two years it said adrs closed 05 lower at 8747 toyota motor corp has for the first time overtaken general motors co as the uss topselling car company by annual sales a change prompted largely by a global computerchip shortage that dealt an uneven blow to the car business adrs rose 7 to a 19919 record closing according to factset based on available data back to march 15 1982