international stocks trading in new york closed lower on wednesday the spbny mellon index of american depositary receipts ticked down 1 to 14024 the european index slipped 11 to 13115 the asian index was down 09 at 16999 the latin american index edged down 02 to 19177 while the emergingmarkets index lost 13 to 28778 canfite biopharma ltd was among those whose adrs traded actively the biopharmaceutical company rose 23 after it said that piclidenoson is set to enter a clinical trial for the treatment of osteoarthritis in dogs through a development and commercialization agreement signed with veterinary biotech company vetbiolix in june 2021 electronic equipment manufacturer kyocera corp ticked down 05 after the company said it will construct a new production facility at its kokubu plant campus to increase its production capacity of multilayer ceramic capacitors