for several years largescale trafficking in apaan a preprecursor of amphetamine and methamphetamine has been of concern to drug control authorities worldwide in the european union following control measures implemented in member states from january both the number of seizures and the amounts of apaan seized have decreased gradually from seizures a total of tons in to seizures tons in in the first half of five incidents involving a total of kg of the substance were reported in december the european union adopted new control measures aimed at preventing the largescale diversion of acetic anhydride from the european union market