yet with fewer than one in six persons with drug use disorders provided with treatment each year the availability of and access to sciencebased services for the treatment of drug use disorders and related conditions remain limited a significant proportion of the large number of premature deaths among people who use drugs is attributable to opioids in addition opioid use disorders account for the heaviest burden of disease attributable to drug use disorders in almost million dalys or per cent of the global burden of disease attributable to drug use disorders were attributable to opioids