Now don't you wish you hadn't done so many helium shots?
People often regret drinking so much because being drunk can be unpleasant, as is having a hangover. But here, instead of doing too many alcohol shots, the person on the ceiling did too many helium shots. Helium is less dense than air, and so things filled with it tend to float, e.g., like balloons, or this man. As his partner points out, he might regret it because he'd probably rather be in bed vs. on the ceiling.