Which of the following statements about the fluroquinolones is FALSE?
Gonococcal resistance to fluoroquinolones may involve changes in DNA gyrase Modification of fluoroquinolones dosage is requyired in patients if creatinine clearance is less than 50 mL/min A fluroquinolone is the drug of choice for treatment of an unconmplicated urinary tract infection in a 7 year-old girl Fluoroquinolones inhibit relaxation of positively supercoiled DNA