A 65-year-old man has anemia, splenomegaly, and extramedullary hematopoiesis. He has experienced easy fatigability, weightloss, and weakness. Bone marrow biopsy reveals marked proliferation of fibrous tissue (myelofibrosis) Which of the following is a characteristic finding in this disorder?
Depletion of bone marrow megakaryocytes Teardrop-shaped erythrocytes Autosplenectomy Neoplastic plasma cells in the bone marrow