A 48 -year-old woman presents with new onset of seizures and behavioral changes that started approximately 6 months ago. Advanced imaging reveals multiple round metastatic lesions in her brain. Her past medical history is remarkable for a black lesion on her toe she had excised 20 years prior. A thorough workup and multiple additional imaging studies reveal no primary malignancy. A lesion on the arm is noted and shown. Which of the most likely characterizes this type of malignancy?
Originates from cells in the stratum basalis Negative staining for I IMB45 Prognosis typically determined by amount of horizontal spread Signet ring cells are commonly seen on histology