All are TRUE about Antineutrophil Cytoplasmic Antibodies, EXCEPT:
Proteinase-3, in neutrophil azurophilic granules, is the major cANCA antigen The major target for pANCA is the enzyme myeloperoxidase A pANCA pattern of staining has been associated with nonvasculitic entities such as rheumatic and nonrheumatic autoimmune diseases There are three major categories of ANCA