A PATIENT ON LITHIUM THERAPY DEVELOPED HTN,HE WAS STAED ON THIAZIDES FOR HYPEENSION .AFTER FEW DAYS HE DEVELOPED COARSE TREMORS AND OTHER SYMPTOMS SUGGESTIVE OF LITHIUM TOXICITY .EXPLAIN THE LIKELY MECHANISM ::
THIAZIDE INHIBIT METABOLISM OF LITHIUM THIAZIDE AXT AS AN ADD ON DRUG TO LITHIUM THIAZIDE INCREASE THE TUBULAR REABSORPTION OF Li THIAZIDE CAUSE LOSS OF WATER THERBY INCREASES Li LEVELS