Despite their sho half lives(2hrs) proton pump inhibitors cause a prolonged suppresion of acid secretiin(upto 48hr) because:
They are prodrugs and undergo activation gradually They exit from the palsma and enter acid secretory canaliculi and stay there blocking the secretion of acid for a long time They irreversibly inhibit the proton pump molecule and hence,acid secretion requires synthesis of new proton pumps They are available as enteric coated capsules,from which drug is gradually released