(Refer to the PDQ Summary on Prevention of Colorectal Cancer for more information.)
Genetic factors appear to influence the age at onset of CRC. People who have a first-degree relative with CRC are estimated to have an average onset of CRC
(Refer to the PDQ Summary on Prevention of Colorectal Cancer for more information.)
Genetic factors appear to influence the age at onset of CRC. People who have a first-degree relative with CRC are estimated to have an average onset of CRC about 10 years earlier than people with sporadic CRC. The increased cancer risk conferred by a family history of CRC appears to manifest itself primarily in people younger than 60 years. Markedly early onset of cancer is seen in hereditary conditions conferring an increased risk of CRC with a mean age at diagnosis of CRC in the early 30s for FAP and in the 40s for LS.[2,3]
For the most part, the effects of other nongenetic risk factors have not been evaluated in people who are