Genomes and Genes
ocular motility disorders
Summary: Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye
Genomes and Genes
ocular motility disorders
Summary: Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240)
Publications187 found, 100 shown here
- Comparison of smooth pursuit eye movement deficits in multiple system atrophy and Parkinson's diseaseElmar H Pinkhardt
Department of Neurology, University of Ulm, 89081 Ulm, Germany
J Neurol 256:1438-46. 2009..The differences in pursuit tracking between PD and MSA were large enough to warrant their use as ancillary diagnostic criteria for the distinction between these disorders...
- Recent progress in understanding congenital cranial dysinnervation disordersDarren T Oystreck
Department of Ophthalmology, College of Medicine, King Saud University, and King Abdulaziz University Hospital, Riyadh, Saudi Arabia
J Neuroophthalmol 31:69-77. 2011..This report provides an update 8 years after that original report...
- Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodiesUrs P Mosimann
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Brain 128:1267-76. 2005..The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease...
- Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson's diseaseAshley J Hood
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA
J Neurol Neurosurg Psychiatry 78:565-70. 2007..Previous studies have shown that patients with PD have impaired executive function, including deficits in attention, motor planning and decision making...
- (1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2Isabelle Iltis
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Brain Res 1358:200-10. 2010..We aimed at assessing the neurochemical profile of the pons, the cerebellar hemisphere and the vermis in patients with FRDA and AOA2 to identify potential biomarkers of these diseases...
- Eye movements in chorea-acanthocytosisLibe Gradstein
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
Invest Ophthalmol Vis Sci 46:1979-87. 2005..In contrast to Huntington's disease (for which ChAc has occasionally been mistaken), ocular involvement in ChAc has not been systematically studied...
- Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafishH A Burgess
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Genes Brain Behav 8:500-11. 2009..Moreover, we show that twitch twice mutants exhibit normal visual acuity but display defects in horizontal eye movements, suggesting a specific and critical role for twitch twice/robo3 in sensory-guided behavior...
- Cerebellar ataxia with oculomotor apraxia type 1: clinical and genetic studiesIsabelle Le Ber
Federation de Neurologie, Hôpital de la Salpêtrière AP HP, Paris, France
Brain 126:2761-72. 2003..The frequency of chorea at onset suggests that this diagnosis should also be considered in children with chorea who do not carry