Genetic Diversity and Evolutionary Dynamics of Influenza A and B Viruses
Influenza viruses are members of the Orthomyxoviridae family whose genomes consist of 8 segments of single-stranded negative-sense RNA
Genetic Diversity and Evolutionary Dynamics of Influenza A and B Viruses
Influenza viruses are members of the Orthomyxoviridae family whose genomes consist of 8 segments of single-stranded negative-sense RNA. Influenza A virus (IAV) and influenza B virus (IBV) are responsible for seasonal epidemics of respiratory illness among humans. While IBV circulates only among humans, IAV circulates among many mammalian and avian hosts. Global surveillance of these viruses is necessary for maintaining a well-matched annual influenza vaccine, as well as for detecting the emergence of new influenza strains that may cause a human pandemic. Hemagglutinin (HA) and neuraminidase (NA) are the two predominant viral glycoproteins found in the viral envelope, and are the primary targets of the host immune system and are key factors in the entry and exit of influenza particles from host cells. HA and NA are also used to classify influenza A viruses into subtypes (e.g., H3N2, H5N1).
Our collaborative influenza projects will: 1) characterize the temporal and spatial evolutionary dynamics of the IAV and IBV circulating globally in humans and wild birds, 2) identify the IAV genotypes circulating in pigs at county fairs (swine-human interface) to determine if fairs produce novel reassortants or enable zoonosis/reverse zoonosis, 3) determine if specific internal gene segment constellations enhance viral fitness, 4) detect epistatic interactions between gene segments, and 5) assess the impact of inter-hemispheric migration of viruses/gene segments.
The accumulation of mutations at antigenic sites (antigenic drift) and the reassortment of segments with differing e