Jornal de Pediatria
Print version ISSN 0021-7557
CINTRA, Otávio A. L. and REY, Luis C.. Safety, immunogenicity and efficacy of influenza vaccine in children
Jornal de Pediatria
Print version ISSN 0021-7557
CINTRA, Otávio A. L. and REY, Luis C.. Safety, immunogenicity and efficacy of influenza vaccine in children. J. Pediatr. (Rio J.) [online]. 2006, vol.82, n.3, suppl., pp. s83-s90. ISSN 0021-7557. http://dx.doi.org/10.1590/S0021-75572006000400010.
OBJECTIVES:To review the immunogenicity, safety and efficacy of inactivated and attenuated trivalent influenza vaccines in children. SOURCES OF DATA: Database search of the medical literature indexed on MEDLINE, LILACS and in the Cochrane Library. Review articles, clinical trials and epidemiological studies published from 1990 to 2006 were selected for analysis. SUMMARY OF THE FINDINGS: Influenza is an infectious disease that is both universal and seasonal, with incidence in all age groups and annual epidemics characterized by excessive morbidity and mortality. The elderly and people with comorbidity are high risk groups for severe influenza. It has recently been proven that healthy infants suffer similar morbidity to other risk groups, and therefore vaccination against influenza is indicated for them too, as being the m