Q17: When developing a design space, one tends to increase batch size from small laboratory batches to medium and large production
batches. Because production size batches are more expensive, how can one minimize the resources used to develop the final
A
Q17: When developing a design space, one tends to increase batch size from small laboratory batches to medium and large production
batches. Because production size batches are more expensive, how can one minimize the resources used to develop the final
A: A significant amount of resources are required to establish a detailed design space using large-scale batches. Using a laboratory
scale model is beneficial to understanding the chemistry and effect of other factors that are scale-independent on the desired
responses. Most of the effort to define ranges and evaluate factors should be done at the laboratory scale(s). One strategy
is to reduce the number of factors and the number of batches as the batch size increases while maintaining the most important
factors. Using laboratory scale models has certain advantages and challenges (see Table II2 ).
Table II2: Advantages and challenges in the use of laboratory-scale models.
One challenge when using a laboratory-scale model is not being able to simulate the impact of scale-dependent factors. Som