E.coli which kill cancer cells.
Biosafety Level 1
- The cancer is top of the cause of death in Japan. And the number of death by cancer are increasing over the world. Even though reseachers study the treatment
E.coli which kill cancer cells.
Biosafety Level 1
- The cancer is top of the cause of death in Japan. And the number of death by cancer are increasing over the world. Even though reseachers study the treatment of cancer strenuously, there are no critical method. We still need early detection and treatment of cancer.
- So,we would like to be help treatment of cancer through this project.
2.The immune system to cancer cells
- Our immune system have an ability to kill cancer cells with complex process. The system is called immunological surveillance. Cancer cells make cancer-associated antigen which was not expressed by nomal cells. If the antigen is expressed with MHC classⅠ, killer T cells eliminate cancer cells by recognizing MHC classⅠ.
- However cancer cells attract regulatory T cells to avoid lymphocytes attacking.Regulatory T cells have receptor called CCR4 which accept chemokine 22(CCL22) which was secreted by cancer cells.
- When CCR4 combine with CCL22, regulatory T cells move to cancer cells. and attracted regulatory T cells inactivate helper T cells and killer T cells.
- Such a mechanism make lose the capital components of immune response towards tumor compromise.(Fig1)
- Natural killer cell is a kind of immune cells participating in an immune system. NK cells have some receptor on the me