This introductory course is intended for students of organic and inorganic chemistry who intend to make use of NMR in their research. The course is descriptive rather than mathematical and does not use quantum mechanics. The focus of the class is technique and not the
This introductory course is intended for students of organic and inorganic chemistry who intend to make use of NMR in their research. The course is descriptive rather than mathematical and does not use quantum mechanics. The focus of the class is technique and not the interpretation of spectra. The class is practical in that ideas will be presented so that, for example, the student will be able to maximize spectral signal-to-noise, or choose the appropriate NOE experiment, or understand when solvent suppresion is needed. The course only meets once per week and is taught in Spring semester only.
Textbook: - High-Resolution NMR Techniques in Organic Chemistry, Claridge, Timothy D. W., Pergamon and
Basic One- and Two-dimensional NMR Spectroscopy, Horst Friebolin, Wiley-VCH 3rd edition 1998.
Class 1: Intro to Basic NMR: Vector diagram picture of NMR. Review of simple 1D spectra: chemical shifts and couplings.. Reading: Friebolin pp 1-12, 22-40
Class 2, 3: Chemical Aspects: Magnetic and chemical equivalence, Pople notation, First order/second order spectra, energy level diagrams. Karplus relationship, Reading: Friebolin pp 70-77, 85-99, 111-126.
Class 3: Survey of info provided by 2D NMR Methods: COSY, DQF-COSY, ROES