title: 'Registration of pre-surgical MRI and whole-mount histopathology images in prostate cancer patients with radical prostatectomy via RAPSODI'
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Keywords: radiology-pathology registration $|$ prostate cancer $|$ whole-mount histopathology $|$ radical prostatectomy $|$ magnetic resonance imaging

Introduction
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Despite advances in diagnosis and treatment, prostate cancer remains the second leading cause of cancer death in American men [@siegel_cancer_2019]. Overdiagnosis of low-grade cancers that do not require treatment and the underdiagnosis of aggressive cancers are still a concern [@futterer_can_2015], even after the changes in the recommendation of prostate biopsy for elevated Prostate Specific Antigen (PSA). Magnetic Resonance Imaging (MRI) can help address all of these problems [@ahmed_diagnostic_2017]. When MRI is normal, up to 50% of men can safely avoid prostate biopsy, thereby reducing overdiagnosis of low-grade cancer and infectious complications of biopsy. However, this is only true when MRI is interpreted by world-leading experts [@van_der_leest_head--head_2019]. In practice, lack of widespread expertise and alarming levels of inter-reader variation greatly reduce the potential of MRI to revolutionize prostate cancer diagnosis [@sonn_prostate_2017]. Both false negatives and false positives, even when using the recommended PIRADS reporting system [@weinreb_pi-rads_2016], are very common and the vast majority of men who undergo MRI still undergo biopsy. Finally, MRI has 