conformational changes combines to give rise to the Vroman effect, we devise here a coarse-grained model of a ternary protein solution mixture in contact with a hydrophobic surface.

The Model
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A full atom simulation of competitive adsorption of proteins from a multicomponent mixture is at present time unfeasible for several reasons. Each protein is made of a large number of amino acids (e.g., 585 for human serum Albumin and more than 2800 for the human Fibrinogen) and is hydrated by thousands of water molecules. As a consequence, a fully atomistic Molecular Dynamics (MD) simulations of one single protein adsorption on a surface with explicit water is limited to a few hundreds of ns [@Wei2012]. This time scale is at least five orders of magnitude smaller than the one necessary to observe competitive adsorption. Moreover, the simulations should be for thousands of proteins.

This challenging task can be undertaken by coarse-graining the system. Coarse-graining can be performed at different levels [@Tozzini2005]. However, modeling a full layer of adsorbed proteins on an extended surface urges to reduce drastically the degrees of freedom. A common strategy is to consider implicit water and to represent the protein as a single particle. As we 