\[Valves reconstruction\]). This 3D reconstruction method is coupled with our in-house CFD code based on a sharp-interface immersed boundary method [@gilmanov2005hybrid; @borazjani2008curvilinear; @borazjani2013parallel] to simulate the ventricular flows (section \[Hybrid echo-CFD framework\]). Different smoothing algorithms, described in section \[Data smoothing\], are tested to dampen the fluctuations of boundaries obtained from echo data. The effect of these smoothing algorithm on shape and flux of LV as well as CFD results are investigated (section \[smoothness in geometric\] and \[numerical simulations smoothing\]). This hybrid echo-CFD framework is applied to a healthy LV and an LV with acute myocardial infarction (AMI) and the results are discussed in section \[Comparing healthy and AMI\].

Methods
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In this section, the previous process for the reconstruction of LV from multiple 2D echo cross-section [@rajan2016automated] is briefly described in \[Previous LV reconstruction method\] subsection. Afterwards, the new developments/modifications to this method are discussed in \[Data smoothing\] to \[Computational setup\] subsections. The new 3D reconstruction method is applied to a healthy LV as well as one with acute myocardial infarction (AMI) which was scanned after inducing AMI on the healthy LV by ligating the mid-portion of the left anterior descending coronary artery (both healthy and AMI images are approved 