as  \[fig:ResultsQualitativeC1\] Raw 2, with the histopathology slice shown with progressive transparency from right-left ( \[fig:ResultsQualitative2\]a) and left to right ( \[fig:ResultsQualitative2\]b) to emphasize the alignment of the two modalities. The qualitative and quantitative evaluation suggest that a good alignment was obtained for this subject.

The accurate registration allowed us to map the extent of two cancer foci with different Gleason groups ( \[fig:ResultsQualitative2\], blue - Gleason group 2; red - Gleason Group 3). Although the higher grade cancer is visible on MRI, its MRI visible borders are smaller than the histopathology projected lesion, confirming previous work showing that MRI underestimates actual tumor size [@priester_magnetic_2017]. The fusion enabled the mapping of the Gleason Group 2 cancer, which is not clearly visible on MRI, and would have been otherwise difficult to outline on MRI.

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[  \[fig:ResultsQualitativeC2\] shows a subject in cohort C2 for which the alignment of the prostate achieved a Dice coefficient of 0.98 and a Hausdorff distance of 2.50 mm on the prostate boundary. As for the results in  \[fig:ResultsQualitativeC1\]-\[fig:ResultsQualitative2\], the results for this subject are average and not outline. The five histopathology images ( \[fig:ResultsQualitativeC2\] Column 1) were registered with the MRI ( \[fig:ResultsQualitativeC2\] Column 2), 