an equilibrium situation is reached. By decreasing the total concentration of protein in the solution, keeping the relative concentrations fixed, the time scales of the process increase and the maxima of surface concentration for each family of proteins occur at longer times.

Our model confirms the intuitive understanding that the sequence of surface occupation is a consequence of a competition between the smaller and faster, but less affine, proteins with the more affine, but bigger and slower, proteins. For example, we test that by increasing the Alb affinity, or artificially setting to the same value all the diffusion constants, the Vroman effect disappears. Therefore, affinity and diffusion constant are relevant protein parameters for the effect as can be deduced by standard kinetics equation models. Nevertheless, our model reveals that the mechanisms of competitions are likely to be more complex that what the intuition would suggest, when conformational changes occurs, with regimes during which small and large proteins are not necessarily competing between them, but are both competing with others in solution.

We find that the protein surface concentrations at equilibrium depend on external control parameters. In particular, we find that energy depletion induces a drastic change in the composition of 