direct information on the handedness of the molecular structure under investigation because only a macroscopic effect is measured. Accordingly, a particularly intriguing question is left open: Which sign of the observed effect is correlated to which of the two possible microscopic structures? This issue is known as the problem of absolute configuration. Most current techniques that distinguish between enantiomers need additional information to infer the absolute configuration. A direct determination, without reliance on theoretical models or semi-empirical rules, has only been possible with anomalous X-ray diffraction as introduced by Bijvoet et al. [@Bijvoet1951]. Whereas the sign of the macroscopic effect (e.g. the optical rotation) leads to designation by (+)/(-) or D/L, Cahn, Ingold and later Prelog coined their famous rules [@Cahn1951] to determine if a molecular structure is right-handed $(R)$ or left-handed $(S)$.\
Chiral molecules have increasingly attracted attention in the physics community in the last two decades because gas-phase techniques have been developed that allow to study isolated chiral molecules. Under these circumstances, solvent and collective effects can be neglected and a deeper understanding of the molecules themselves and their light-matter interaction is possible. A list of major techniques encompasses Photoelectron Circular Dichroism (PECD) [@Janssen2014], microwave spectroscopy [@Patterson2013], and 