---
abstract: 'The effect of heart geometry and anisotropy on cardiac re-entry dynamics and self-termination is studied here in anatomically realistic computer simulations of human foetal heart. 20 weeks of gestational age human foetal heart isotropic and anisotropic anatomy models from diffusion tensor MRI data sets are used in the computer simulations. The fiber orientation angles of the heart were obtained from the DT-MRI primary eigenvalues. In a spatially homogeneous electrophysiological mono domain model with the DT-MRI based heart geometries, we initiate simplified Fitz-Hugh-Nagumo kinetics cardiac re-entry at a prescribed location in a 2D slice, and in the full 3D anatomy model. In a slice of the heart, the MRI based fiber anisotropy changes the re-entry dynamics from pinned to anatomical re-entry. In the full 3D MRI based model, the foetal heart fiber anisotropy changes the re-entry dynamics from a persistent re-entry to the re-entry self-termination. Time of re-entry self-termination depends on the re-entry initial position. Anisotropy of the heart speeds up re-entry self-termination.'
author:
- 'I.V.Biktasheva'
- 'R.A.Anderson'
- 'A.V.Holden'
- 'E.Pervolaraki'
- 'F.C.Wen'
title: 'Cardiac re-entry dynamics & self-termination in DT-MRI based model of Human Foetal Heart'
---

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> The effect of the heart anisotropy and anatomy 