only oxygen or nitrogen in addition to carbon and hydrogen. The crucial question in this case will be if the levels of the carbon atoms differ enough to enable a selective excitation.

Conclusion
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The chiral ethane derivative halothane was investigated using X-ray photons for core ionization and a COLTRIMS-setup for coincident detection of the fragments. A separated signal of the two enantiomers could be found in several four-body Coulomb explosion pathways. The CF${}_{3}^{+}$ cation is an example of a complete functional group that was used to determine absolute configuration. This finding is an encouraging step towards application of the method to biologically relevant molecules. Due to multiple possible fragmentation pathways, however, the yield of chirality-sensitive pathways was very low.\
The site-selective excitation of the two carbon atoms was investigated for four-body fragmentations and in the case of double ionization, leading to two-body fragmentation. Two of the four-body fragmentation pathways show an increase for photon energies where both carbon atoms can be photoionized. In the case of two-particle break-ups, the splitting of the CF${}_{3}^{+}$ from the rest of the molecule clearly correlates with excitation of the C${}_{\mathrm{F}}$. For other break-ups, the contribution of chlorine and bromine shells is dominant, providing 