processing.]{}

*MRI:* The MRI exams for the patients in cohort C1 were acquired using 3 Tesla scanners (MR750, GE Healthcare, Waukesha, WI) with an external 32-channel body array coil without an endorectal coil. The imaging protocol included T2 weighted MRI (T2w), diffusion weighted imaging (DWI) and derived Apparent Diffusion Coefficient (ADC), and dynamic contrast-enhanced imaging sequences. For the patients in Cohort C2 were acquired on a 3T scanner (Siemens) using an endorectal coil. The public repository provides T2w MRI and dynamic contrast-enhanced MRI for these patients. In this study, we utilized the Axial T2w MRI, which is acquired using a 2D Spin Echo protocol ( \[tab:data\])

*Histopathology:* The cohort C1 patients, following resection, the prostate was fixed in formalin, sectioned using a patient-specific 3D printed mold built based on the pre-surgical MRI to maintain the correspondence of histopathology slices and T2w images, and embedded in paraffin. This process is now part of our clinical standard of care. The histopathology for the patients in cohort C2, was cut without the use of 3D printed molds, but seeking gross sectioning perpendicular to the urethra. Mounting of the 5$\mu m$ thick tissue on the glass slide can result in a rotation of the 