of cancer, including sarcoma, melanoma, and cancers of the head and neck, brain, lung, esophagus, breast, bladder, rectum, liver, appendix, cervix, etc. .

Hyperthermia treatment planning involves modeling patient-specific tissue, using medical imaging techniques such as microwave, ultrasound, magnetic resonance or computed tomography, and calculating the spatial distribution of power deposited in the tissue to heat it [@13:; @Paulides]. There exist two major techniques to concentrate the power in a well-defined tumor region: electromagnetic and ultrasound, each with its own limitations. The drawback of electromagnetic microwaves is poor penetration in biological tissue, while for ultrasound the short acoustic wavelength renders the focal spot very small. Using signal design methods, however, one can improve the spatial power deposition generated by an array of acoustic transducers. Specifically, standard phased array techniques do not make use of combining a diversity of signals transmitted at each transducer. When this diversity exploited it is possible to dramatically improve the power distribution in the tumor tissue, thus improving the effectiveness of the method and reducing treatment time . Given a set of spatial coordinates that describe the tumor region and the healthy tissue, respectively, the transmitted waveforms can be designed to optimize the spatial power distribution 