date: 'University of Michigan, Ann Arbor'
title: 'The micromechanics of fluid-solid interactions during growth in porous soft biological tissue'
---

Introduction {#sec:1}
============

*Growth* involves the addition or depletion of mass in biological tissue. Growth occurs in combination with *remodelling*, which is a change in microstructure, and possibly with *morphogenesis*, which is a change in form in the embryonic state. The physics of these processes are quite distinct, and for modelling purposes can, and must, be separated. Our previous work [@growthpaper], upon which we now seek to build, drew in some measure from @CowinHegedus:76 [@EpsteinMaugin:2000], and @TaberHumphrey:2001, and was focused upon a comprehensive account of the coupling between transport and mechanics. The origins of this coupling were traced to the balance equations, kinematics and constitutive relations. A major contribution of that work was the identification and discussion of several driving forces for transport that are thermodynamically-consistent, in the sense that specification of these relations does not violate the Clausius-Duhem dissipation inequality.

There have been a number of significant papers on biological growth and remodelling in the last 7–8 years of which we touch upon some, whose approaches are either similar to ours in some respects or differ in important ways. 