\times 201$ grid points in x, y and z directions, respectively.

Results and discussion
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Here, the effect of fixed apex assumption on the final surface reconstruction and LV flux is studied. In addition, the sensitivity of the results (reconstruction and CFD simulations) to the smoothing algorithm is investigated. Furthermore, the effect of ventricular valves especially the MV on the flow field in the LV is studied. Finally, the flow hemodynamics of healthy and AMI LVs are compared with each other. The presented results are for healthy LV based on VSWMA smoothing algorithm unless it is mentioned otherwise.

Effect of change in positioning and orientation of the LV sections on LV geometry
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As previously mentioned, the assumption of the fixed apex is more realistic compared to fixed SA basal section since the apex has the least displacement in LV geometry during a cardiac cycle [@rogers1991quantification]. This assumption will affect the final reconstructed geometry and volumetric flux of LV during a cardiac cycle. Figure \[orientation-effect\] shows the volumetric curve of the reconstructed LV with the assumption of having the apex fixed compared to the one with SA basal section fixed at various time instances during a cardiac cycle. The difference 