- &0.53$\pm$0.18\
All & 0.98$\pm$0.01 & 1.71$\pm$0.48 & 2.91$\pm$1.25 & 2.88$\pm$0.70 & 0.53$\pm$0.18\

Additional evaluation was possible in cohort C2, since the authors of the dataset [@madabhushi_fused_2016] have provided the mapped cancer obtained via landmark-based registration [@singanamalli_identifying_2016]. Thereby, we compared the mapped cancer from RAPSODI with those provided by the dataset authors, and we observed a dice coefficient of $0.53\pm 0.18$ and deviation computed on the center of mass of $2.71\pm 1.31$ mm. The relatively reduced alignment of the cancer labels may be attributed to the general misalignment error, which is within 3 mm inside the prostate and 2 mm on the prostate border. This misalignment can have a significant effect on the value of the overlap evaluated via Dice coefficient for regions of small size, such as the cancer.

Due to the use of stitched histopathology images, and of endorectal coil MRI, larger deformations needed to be recovered when aligning the histopathology images to MRI in the patients in cohort C2. The pseudo-whole mounts can have stitching artifacts that are absent in the whole-mount histopathology images. For example, the stitched pseudo-whole mount images are elongated in the anterior-posterior direction, e.g. slice C1234 of patient aaa0054. The affine parameters, i.e. 