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abstract: 'Metastasis is a process of cell migration that can be collective and guided by chemical cues. Viewing metastasis in this way, as a physical phenomenon, allows one to draw upon insights from other studies of collective sensing and migration in cell biology. Here we review recent progress in the study of cell sensing and migration as collective phenomena, including in the context of metastatic cells. We describe simple physical models that yield the limits to the precision of cell sensing, and we review experimental evidence that cells operate near these limits. Models of collective migration are surveyed in order understand how collective metastatic invasion can occur. We conclude by contrasting cells’ sensory abilities with their sensitivity to drugs, and suggesting potential alternatives to cell-death-based cancer therapies.'
author:
- Julien Varennes
- Andrew Mugler
title: ' Sense and sensitivity: physical limits to multicellular sensing, migration and drug response'
---

Metastasis is one of the most intensely studied stages of cancer progression because it is the most deadly stage of cancer. The first step of metastasis is invasion, wherein cells break away from the tumor and invade the surrounding tissue. Our understanding of metastatic invasion has benefited tremendously from genetic 