our system changes from $0.5\%$, weak confinement, to $25\%$ for strong confinement regime; comparable to the nucleus volume fraction. It has been confirmed that the heterochromatin in normal eukaryotic cells is mainly positioned at the periphery and anchored to the nuclear lamina by tethering and euchromatin is mainly at interior space ready for gene expression and replication [@Lanctot; @Bickmore; @Akhtar]. Our results, qualitatively represent a mechanism which can organize and position the segments based on their structural properties, i.e. stiffness and length. In case of strong confinement regime, this entropy-driven segregation mechanism pushes the longer stiff segments, heterochromatin, towards the periphery where they can find a proper tethering site, and more flexible chains, euchromatin, are located at interior space; making distinction between components of the system. Our findings qualitatively show that besides all other active metabolism for nucleus organization [@Lanctot; @Bickmore], the entropic effect potentially can play an important role in nucleus organization [@Jun15082006; @Cook21092009; @Axel].

Higher mobility of the chain at the periphery and mobility of other chains show another possible implication for biological systems like chromosomes inside the nucleus where during their recombination process, gene expression, or search for tethering site on nuclear lamina, the components should diffuse 