the other hand HFETfR2 degradation, hepcidin expression, hepcidin degradation and TfR2 binding 2, have low control in the reference steady state, but could have significant control in the global sense. All other reactions have low control in any situation.

In the case of the control of hepcidin concentration (Table \[table:MCAHepc\]) the differences between the reference state and the global are much smaller overall, and one could only identify a few reactions that have moderate control in the reference, but could have a bit less in the global sense (TfR2 expression, TfR2 binding, and TfR2 iron internalisation).

In the case of the control of the flux of iron export (Table \[table:MCAFlux\]), we find some reactions with high control in the reference that could have low control in the global sense: TfR1 expression, TfR1 biding, TfR1 degradation, IRP expression and IRP degradation. Hepcidin expression, hepcidin degradation, and HFETfR2 degradation have almost no control in the reference, but in the global sense they could exert considerable control. This is very similar to the situation of the control of the labile iron pool.

Chifman [*et al.*]{} [@Chifman2012Core] analysed the parameter space of their core model of iron metabolism in breast epithelial cells and concluded 