irreversible is the adsorption process on a specific surface.

For an irreversible adsorption process, our findings predict that by appropriately controlling the parameters of the protein solution, such as the amount of depleted energy, it is possible to engineering a specific biomimetic covering of a surface. Due to the irreversibility, the proteins, once adsorbed, cannot easily desorb from the surface, even if the external conditions are modified. Therefore, it is feasible to cover a device surface with any desired protein composition, targeted to a specific biomimetic property, by selecting an appropriate initial condition. Subsequently, the device could be used under physiological conditions with no further changes of the protein cover and its biomimetic properties.

Conclusions
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We study, by MD simulations of a coarse-grained model, the Vroman effect for a ternary protein solution mixture, with Alb, IgG and Fib, in contact with a hydrophobic surface. We show that the effect is the consequence of the differences among the proteins properties: mass and size, affinity, diffusion constant, conformational changes. These differences lead to a process of competitive adsorption on a surface, in which the different families of proteins occupy sequentially the surface, replace each other and diffuse at the surface, until 