the second. The final equilibrium concentrations are reached at large times. We observe also a sudden change in $C_A^S$ of Alb, between the two equilibrium concentrations characteristics of the two values of the external parameters $T$. However, $C_A^S$ always equilibrates to a value that is smaller then $C_I^S$ and $C_F^S$, consistent with its long-time values in Fig. \[f1\]-\[f2\]. By decreasing $X_P$, we find the same qualitative behavior for a sudden energy-change, but with the transient regime extending to longer times, consistent with Fig. \[f2\]. Hence, at experimental values of $X_P$ the switching behavior would occur on time scales that are comparable to those characteristic of the Vroman effect.

Reversible vs Irreversible Adsorption
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We remark that our predictions about inverting the Vroman effect by changing the experimental control parameters should hold only if the protein adsorption on the surface is reversible. If the adsorption is, instead, irreversible the change of external parameters should not lead to a new composition of the protein layer. Indeed, under many practical conditions of interest for blood plasma, it would appear that the binding is indeed mostly irreversible [@Mono2011; @Lundqvist2011]. Hence, the switching protocol proposed above represents a possible experimental way to evaluate how strongly 