Deckard watches a video of a Blade Runner named Holden administering the "Voight-Kampff" test designed to distinguish replicants from humans based on their emotional response to questions. The test subject, Leon (Brion James), shoots Holden after Holden asks about Leon's mother. Bryant wants Deckard to retire Leon and the other three replicants: Roy Batty (Rutger Hauer), Zhora (Joanna Cassidy), and Pris (Daryl Hannah). Deckard initially refuses, but after Bryant ambiguously threatens him, he reluctantly agrees.
Deckard begins his investigation at the Tyrell Corporation to ensure that the test works on Nexus-6 models. While there, he discovers that Dr. Eldon Tyrell's (Joe Turkel) assistant Rachael (Sean Young) is an experimental replicant who believes herself to be human. Rachael has been given false memories to provide an "emotional cushion". As a result, a more extensive test is required to determine whether she is a replicant.