Will Graham (William Petersen) is a former FBI criminal profiler who has retired because of a mental breakdown after being attacked by a cannibalistic serial killer, Dr. Hannibal Lecktor (Brian Cox) whom he captured. Graham is approached at his Florida home by his former FBI superior Jack Crawford (Dennis Farina), who is seeking help with a new serial killer case. Promising his wife (Kim Greist) that he will do nothing more than examine evidence and not risk physical harm, Graham agrees to visit the most recent crime scene in Atlanta, where he tries to enter the mindset of the killer, now dubbed the "Tooth Fairy" by the police for the bite-marks left on his victims.