Damaskinos betrays Blade and Whistler, revealing that he created the Reaper virus in order to create a new race of vampires and that Nomak is in fact his son. Scud turns out to be a familiar loyal to Reinhardt, who also works for Damaskinos. Explaining that he always knew of Scud's true allegiance, Blade kills him with the bomb he placed earlier. Damaskinos then orders his scientists to dissect Blade so that he can learn how to replicate his abilities. After escaping his captors, Whistler brings Blade to a blood vault, where he regains enough strength to kill Reinhardt and his men.
Seeking revenge, Nomak tracks Damaskinos to his private heliport and kills him. He then bites Nyssa, infecting her with the virus. Blade confronts Nomak and helps him commit suicide to end his suffering. Fulfilling Nyssa's dying wish, Blade takes her outside, where she dies while watching the sun rise. The movie ends with Blade in London, where he kills Rush, a vampire he encountered earlier in the movie.