Two years after the events of Blade, a pandemic known as the "Reaper virus" has spread through the vampire community. Infected vampires are turned into Reapers, mutants immune to all vampire weaknesses with the exception of bright light. Unable to contain the Reapers, vampire lord Eli Damaskinos sends two emissaries, Asad and Nyssa, to seek the aid of vampire hunter Blade and his team, consisting of weaponsmith Abraham Whistler and his assistant Scud. Damaskinos introduces them to the Bloodpack, a group of vampires trained for the sole purpose of killing Blade. In addition to Asad and Nyssa, the Bloodpack consists of Reinhardt, Chupa, Snowman, Verlaine, her lover Lighthammer, and Priest. To keep them in line, Blade plants an explosive charge on the back of Reinhardt's head.