When Blade attempts to rescue Karen from Frost's penthouse, he finds that his mother is one of Frost's followers. He is subdued and taken to the Temple of Eternal Night, where Frost plans to perform the summoning ritual for La Magra, the vampire blood god. Blade is drained of his blood, but Karen allows him to drink from her, triggering his vampirism. Frost completes the ritual and obtains the powers of La Magra. Blade kills all of Frost's minions, including his mother, and confronts him. During their fight, Blade injects Frost with all of the syringes, causing his body to explode.
Karen offers to help Blade cure himself, but he asks her to create a new serum instead. In a brief epilogue, Blade kills a group of Russian vampires.