"Zerophilia" is a fictional condition that affects an unknown number of people with an extra "Z" chromosome. Following their first full sexual experience, zerophiliacs begin to change sex after experiencing an orgasm. Luke (Taylor Handley), a young man somewhat insecure about his masculinity, begins to exhibit zerophilia following an encounter with a woman (Kelly Le Brock). He meets Michelle (Rebecca Mozo) and experiences partial transformations when they go out together.