lose. james is not easily replaced, and defenses aren't going to fear rhodes/mungro/maroney(or whoever they draft), so the play action isn't going to be as effective. Whichever back they put in there isn't going to be as good as James at picking up blitzes/pass protection, so Manning is going to get even more of what the steelers/charges brought toward the end of the season.  so, they will lose.