### SNORD35A Gene Overview

**Gene Symbol**: SNORD35A  
**Function**: The SNORD35A gene encodes a small nucleolar RNA (snoRNA) that is primarily involved in the modification of ribosomal RNA (rRNA). It is categorized as a C/D box snoRNA, which indicates it is involved in the methylation of rRNA, facilitating proper ribosome structure and function.

### 1. Associated Genes
While the summaries captured the primary functions of SNORD35A, there may be regulatory interactions with other genes involved in glucose metabolism and insulin signaling. Some associated genes that are often related due to their involvement in metabolic processes include:

- **INS** (Insulin)
- **GLUT4** (Glucose transporter type 4)
- **PKA** (Protein Kinase A)
- **AMPK** (AMP-activated protein kinase)
  
These genes are crucial for glucose uptake and utilization, particularly in muscle and adipose tissues, which are functions that may indirectly relate to SNORD35A.

### 2. Aging and Age-Related Diseases
The effects of SNORD35A on aging and age-related diseases are not extensively documented. However, given its involvement in glucose metabolism and insulin secretion, it may play a role in conditions such as:

- **Type 2 Diabetes**: Dysregulation of insulin secretion and glucose metabolism is a hallmark of T2D, which commonly occurs with aging.
- **Obesity**: Age-related changes often lead to obesity, wherein glucose metabolism becomes impaired, potentially implicating the role of SNORD35A.
  
Further research is needed to establish any direct involvement of SNORD35A in aging or specific age-related diseases.

### 3. Drugs and Drug Classes
Currently, specific drugs directly interacting with SNORD35A are not extensively characterized in the literature. However, drugs that target pathways impacting glucose metabolism or insulin signaling may indirectly affect the gene's function. These may include:

- **Insulin**: For diabetes management.
- **Metformin**: Used in the treatment of type 2 diabetes, impacting glucose metabolism.
- **Glitazones**: Thiazolidinediones (TZDs) that enhance insulin sensitivity might also relate to its function.

Further studies are necessary to elucidate any direct pharmacological links to SNORD35A.

### 4. Pathways and Biological Processes
SNORD35A is involved in several pathways and biological processes, including:

- **Ribosome Biogenesis**: As a snoRNA, SNORD35A plays a role in the processing and methylation of rRNA, essential for ribosome structure.
- **Glucose Metabolic Process**: Predicted to regulate glucose metabolism, influencing energy homeostasis.
- **Insulin Secretion Pathway**: Contributing to the regulation of insulin secretion from pancreatic beta-cells.
- **Reactive Oxygen Species Metabolic Process**: Tied to oxidative stress responses that can influence cellular aging and metabolism.

In summary, while SNORD35A’s primary functions relate to RNA modification and glucose metabolism, its impact on aging, associated genes, and pharmacological interactions require additional research for a comprehensive understanding.