### PCDHB8 Gene Overview

**Gene Symbol:** PCDHB8  
**Location:** Chromosome 5  
**Gene Cluster:** Protocadherin beta cluster

The PCDHB8 gene encodes a protein that is part of the protocadherin family, specifically within the beta cadherin subcluster. It plays an essential role in calcium-dependent cell adhesion, particularly in the development and function of neural networks by mediating homophilic cell-cell interactions.

### 1. Other Associated Genes

PCDHB8 is part of the PCDH beta gene cluster, which includes other protocadherin beta genes such as:
- PCDHB1
- PCDHB2
- PCDHB3
- PCDHB4
- PCDHB5
- PCDHB6
- PCDHB7
- PCDHB9
- PCDHB10
- PCDHB11
- PCDHB12
- PCDHB13
- PCDHB14
- PCDHB15
- PCDHB16

Additionally, it may interact with genes that are functionally linked to neuronal development and plasticity, although specific associations beyond the cluster are not commonly detailed in literature.

### 2. Aging and Age-related Diseases

While direct research specifically linking PCDHB8 to aging or age-related diseases is limited, there are indirect associations derived from its role in neural connections. Alterations in protocadherin expression have been observed in age-related neurodegenerative diseases, including:
- Alzheimer’s disease
- Parkinson’s disease

Dysfunction of cell-cell adhesion mechanisms due to changes in genes like PCDHB8 might contribute to the synaptic degeneration seen in these conditions.

### 3. Drug Interactions

As of the latest available data, there are no specific drugs or drug classes distinctly documented to interact directly with PCDHB8. However, due to its involvement in neural cell adhesion and connections, potential indirect interactions with neuroactive substances or drugs targeting synaptic function may exist. Further research would be required to clarify these interactions.

### 4. Pathways and Biological Processes

PCDHB8 is involved in several critical biological processes:

- **Cell Adhesion:** Integral in mediating specific cell-cell adhesion in neural tissues, contributing to the organization of neurons in the brain.
- **Neuronal Development:** Plays a role in the establishment of neuronal networks during development, influencing brain architecture and connectivity.
- **Embryonic Development:** Associated with processes that involve cellular interactions and signaling pathways during early development.
- **Synapse Formation and Stability:** Involved in synaptic connectivity, crucial for maintaining effective communication between neurons.

The protein likely plays a part in various signaling pathways related to neural function, although specific pathways have yet to be extensively detailed in the literature.

### Summary

The PCDHB8 gene is a crucial component of the protocadherin beta cluster, with a key role in neural cell adhesion and potential implications in neurodevelopment and disease. Further studies particular to its interactions and functions may reveal deeper insights into its roles in health and disease.