The IL2RA gene encodes the alpha chain (CD25) of the interleukin-2 receptor, which is crucial for the regulation of immune responses, particularly involving T cells. Below, you will find additional information organized according to your requests.

### 1. Related Genes
In addition to IL2RA, the following genes are often associated with it:

- **IL2RB (Interleukin 2 receptor beta)**: Works in tandem with IL2RA to form the high-affinity receptor for interleukin-2.
- **IL2RG (Interleukin 2 receptor gamma)**: The common gamma chain that also contributes to the formation of the high-affinity receptor complex.
- **FOXP3 (Forkhead box P3)**: A transcription factor critical for the function of regulatory T cells (TREGs), which are influenced by IL2 signaling.
- **STAT5A/B (Signal Transducer and Activator of Transcription 5A/B)**: These proteins are involved in signaling downstream of the IL2 receptor and are essential for T cell growth and differentiation.

### 2. Aging and Age-Related Diseases
Research has indicated that dysregulation of IL2RA and associated pathways may contribute to age-related immune decline, such as:

- **Immunosenescence**: The deterioration of the immune system with age, where alterations in T cell populations, including decreased regulatory T cells (TREGs) function, can occur.
- **Autoimmune Disorders**: Increased susceptibility in older adults, possibly linked to altered IL2RA function or levels, may impact the balance of TREG activity and autoreactive T cells.
- **Inflammation**: Chronic inflammation associated with aging (inflammaging) may also affect IL2RA expression and function, influencing overall immune responsiveness.

### 3. Drug Interactions
Several drugs and drug classes interact with the IL2RA pathway:

- **Immunosuppressants**: 
  - *Daclizumab*: A monoclonal antibody targeting IL2RA, used to prevent organ transplant rejection and in multiple sclerosis treatment.
  - *Basiliximab*: Another monoclonal antibody that blocks IL2R, used for preventing transplant rejection.

- **Targeted Therapies**: Certain cancer therapies target pathways involving IL2RA due to its role in T cell regulation in tumors.

### 4. Pathways and Biological Processes
The IL2RA gene is involved in several important biological pathways, including:

- **Cytokine-cytokine receptor interaction**: Direct involvement in the signaling pathways activated upon binding of interleukin-2.
- **T cell activation**: Plays a critical role in the activation and proliferation of T lymphocytes.
- **Regulatory T cell development and function**: Involved in maintaining immune tolerance and preventing autoimmunity by facilitating the production and function of TREGs.
- **Signal Transduction**: Mediates JAK-STAT signaling, specifically STAT5 activation, which is crucial for gene expression following IL-2 receptor signaling.
  
These pathways highlight IL2RA's integral role in modulating immune responses, influencing various physiological and pathological conditions, particularly in immune system regulation, cancer, and potentially in aging-related immune dysfunction.