### SNORD113-8 Gene Overview

**Gene Symbol:** SNORD113-8  
**Type:** Small nucleolar RNA (snoRNA) gene  
**Location:** Human Chromosome 14, specifically found in the 14q32 region.

### Function

SNORD113-8 is part of the C/D box small nucleolar RNA (snoRNA) family, which is primarily involved in the modification of ribosomal RNA (rRNA) and plays a role in ribosome biogenesis. The snoRNAs guide the specific methylation of rRNA by directing the associated proteins to their target sites, thereby contributing to the proper assembly and function of ribosomes in protein synthesis.

### 1. Associated Genes

While the NCBI and UniProt summaries may not explicitly list associated genes, small nucleolar RNAs often function in concert with a variety of ribosomal RNA genes and other snoRNA genes. In particular, SNORD113-8 may be associated with the following:

- **Other SNORD genes:** Many SNORD genes form clusters and share regulatory mechanisms. For example, SNORD113-1 through SNORD113-10 (a cluster of snoRNAs) may demonstrate related function or regulation.
- **Ribosomal protein genes:** Since snoRNAs are involved in rRNA modification, they might also interact with genes coding for ribosomal proteins.

### 2. Aging and Age-related Diseases

Currently, specific research linking SNORD113-8 directly to aging or age-related diseases is limited. However, snoRNAs in general have been implicated in various cellular processes that can influence aging and age-related diseases, including:

- **Ribosome biogenesis and stress response:** Dysregulation of ribosomal RNA modifications can affect protein synthesis, impacting cellular homeostasis, which may have implications for aging.
- **Cancer:** Some snoRNA members have been shown to be involved in tumorigenesis, and aberrant expression of snoRNAs has been associated with various cancers. Although not directly linked to aging, cancer is a significant age-related disease.

### 3. Drug Interactions

As of the latest information, there are no specific drugs or drug classes widely known to directly interact with SNORD113-8. Due to the nature of snoRNAs primarily facilitating internal cellular processes like ribosome modification, they are less likely to be direct targets of conventional pharmacological agents. However, compounds affecting ribosomal biogenesis or general RNA function may indirectly influence the activity of snoRNAs, including SNORD113-8.

### 4. Pathways and Biological Processes

SNORD113-8 is primarily involved in:

- **Ribosome biogenesis:** Its main function involves guiding the methylation of rRNA, crucial for the formation of ribosomal subunits.
- **RNA modification:** Participation in the modification of rRNA signifies its role in post-transcriptional regulation of gene expression.
  
### Summary

SNORD113-8 is a small nucleolar RNA with essential roles in ribosome biogenesis and rRNA modification. Although detailed information about its connections to aging and drug interactions remains sparse, it is integral to fundamental cellular processes. Further research is necessary to elucidate its potential implications in health and disease, especially concerning aging and related pathologies.