### Gene Overview: LDHBP3

**Gene Symbol:** LDHBP3  
**Common Name:** L-lactate dehydrogenase B-containing protein 3

**Function:** The LDHBP3 gene encodes a protein that is a member of the lactate dehydrogenase (LDH) family of enzymes, which play a key role in the conversion of pyruvate to lactate and vice versa. It is involved in cellular metabolism, particularly in the context of anaerobic respiration and glucose metabolism.

### 1. Associated Genes

While specific associated genes may not have been mentioned in the provided summaries, LDHBP3 may have relationships with other genes related to lactate metabolism, cellular respiration, and energy production. These may include:

- **LDHA** (Lactate dehydrogenase A)
- **LDHB** (Lactate dehydrogenase B)
- **PKM** (Pyruvate kinase muscle)
- **PCK1** (Phosphoenolpyruvate carboxykinase 1)

### 2. Aging and Age-Related Diseases

LDHBP3 may have implications in aging due to its role in metabolic pathways. Alterations in lactate metabolism have been associated with:

- **Sarcopenia:** Reduced muscle mass and function observed in aging individuals could be linked to changes in energy metabolism, with LDH being involved in muscle responses to physical activity.
- **Metabolic disorders:** Changes in lactate levels are indicative of various metabolic diseases, which may also be more prevalent in older populations.
- **Neurodegenerative diseases:** High lactate levels have been associated with conditions like Alzheimer’s disease and might indicate a role for LDH enzymes, including LDHBP3, in brain metabolism during aging.

### 3. Drugs and Drug Classes

There are currently no specific drugs directly known to target LDHBP3. However, drugs and drug classes that influence lactate dehydrogenase activity or metabolic pathways may indirectly interact with its functions. These could include:

- **Lactate dehydrogenase inhibitors:** Although specific inhibitors of LDH enzymes may not be targeted at LDHBP3 specifically, broader LDH inhibitors such as oxamate or gossypol could be relevant depending on their specificity.
- **Agents affecting glucose metabolism:** If there are therapies aimed at conditions like diabetes or ischemic injuries, they may indirectly affect pathways where LDHBP3 is involved.

### 4. Pathways and Biological Processes

LDHBP3 is involved in several key pathways and biological processes, including:

- **Lactate metabolism:** It is critical in the conversion of lactate and pyruvate, contributing to cellular energy production, especially under anaerobic conditions.
- **Glycolysis:** Plays a role in the glycolytic pathway, which is essential for providing energy to cells during high-intensity exercise.
- **Cellular response to hypoxia:** LDH enzymes are upregulated under hypoxic conditions to help facilitate anaerobic metabolism.
- **Regulation of glycolytic flux:** In metabolic reprogramming, particularly in cancer cells, LDH enzymes like LDHBP3 can influence the balance between fermentation and oxidative phosphorylation.

This multi-faceted involvement of LDHBP3 underscores its importance in metabolism, aging, and potentially in therapeutic contexts for various diseases. Further studies would be required to clarify its role in specific pathways and its interactions with environmental factors and drugs.