### HSPE1P26 Gene Overview

**Gene Symbol:** HSPE1P26  
**Alias:** HSPE1P26  
**NCBI Gene ID:** 100506144  
**UniProt Accession:** Q96NX1  

#### 1. Associated Genes
The HSPE1P26 gene is primarily categorized as a pseudogene related to the HSPE1 gene (Heat shock 10-kDa protein 1), which plays a role in the response to stress. Due to the nature of pseudogenes, HSPE1P26 may be less frequently linked to other genes or directly implicated in specific functions. However, it may exhibit sequence similarities with other genes involved in chaperone activity or stress response pathways. Notable associated genes could include:

- **HSPE1 (Heat Shock Protein 10)**
- **HSPH1 (Heat Shock Protein Family H (Hsp110) Member 1)**
- **HSPA8 (Heat Shock Protein Family A Member 8)**

#### 2. Aging and Age-Related Diseases
Currently, there is limited direct evidence linking HSPE1P26 to aging or age-related diseases. However, as a pseudogene associated with the HSPE1 gene, which is involved in protein folding and protection under stress conditions, there may be indirect implications for cellular stress responses during aging processes. Heat shock proteins are generally known to play a protective role in cellular damage which can accumulate with age. Additionally, aberrations in heat shock protein functions have been implicated in several age-related diseases including:

- Neurodegenerative diseases (e.g., Alzheimer's disease)
- Cardiovascular diseases
- Cancer

Given the potential role of heat shock proteins in maintaining cellular homeostasis, any dysregulation could suggest involvement of HSPE1P26 in aging.

#### 3. Drug Interactions
As HSPE1P26 is recognized as a pseudogene, it does not have direct pharmacological targets or known drug interactions. However, drugs targeting the molecular pathways involving its functional counterpart HSPE1 or other related genes—including those that affect chaperone functions or cellular stress responses—may indirectly interact with biological processes where HSPE1P26 may play a role. Common drug classes that target related pathways might include:

- **Heat shock protein inhibitors** (these may affect the overall pathway involving HSPE1 and chaperones)
- **Antioxidants** (indirectly related to cellular stress response)

#### 4. Pathways and Biological Processes
- **Protein Folding and Chaperone Activity:** HSPE1P26 is related to the response to stress, particularly under conditions of heat shock, where it is believed to assist in protein refolding.
- **Cellular Response to Stress:** Involved in protecting cells against damage from various stressors, though the pseudogene itself may not exhibit direct functional activity.
- **Developmental Processes:** Pseudogenes can sometimes be involved in regulatory processes, impacting gene expression indirectly.
- **Apoptosis and Cell Viability:** Given that many heat shock proteins are involved in these pathways, there may be an indirect influence on cell survival during cellular stress responses.

### Summary
The HSPE1P26 gene serves as an interesting subject due to its pseudogene status and its relationship with the HSPE1 gene, which has implicated roles in stress response and potential indirect influences on aging and age-related diseases. While limited data exists on direct associations and pharmacological interactions, the general context of heat shock proteins provides a relevant framework for understanding its possible implications.