### IL36B Gene Overview

**Gene Symbol:** IL36B  
**Location:** Chromosome 2 (cytokine gene cluster)  
**Protein Structure:** Member of the interleukin-1 cytokine family with a predicted 12-stranded beta-trefoil structure.

**Function:** The IL36B gene encodes a pro-inflammatory cytokine involved in immune response. It influences various signaling pathways and cellular processes through its receptor, IL1RL2/IL-36R. This interaction activates NF-kappa-B and MAPK signaling pathways, essential for mediating the inflammatory response.

### Additional Information

#### 1. Associated Genes
In addition to IL36B, other members of the interleukin-1 family that share a significant association or relation include:
- **IL1A (Interleukin 1 Alpha)**
- **IL1B (Interleukin 1 Beta)**
- **IL36A (Interleukin 36 Alpha)**
- **IL36C (Interleukin 36 Gamma)**
- **IL1RL2 (Interleukin 1 Receptor Like 2)** 
- **IL1RAP (Interleukin 1 Receptor Accessory Protein)**

There may also be connections with cytokines involved in inflammatory and immune response pathways beyond the immediate cluster, such as other interleukins (e.g., IL-6, IL-8), CCL and CXCL chemokines, and TNF-alpha.

#### 2. Aging and Age-Related Diseases
Recent studies have implicated IL36B in various aging-related processes and diseases. Notable areas include:
- **Chronic Inflammation:** IL36B's role in pro-inflammatory responses may contribute to chronic inflammation associated with aging (inflammaging), which is correlated with age-related diseases, including cardiovascular diseases, arthritis, and neurodegenerative disorders.
- **Skin Aging:** IL36B influences skin inflammatory responses and may play a role in conditions such as psoriasis, eczema, and other skin-related issues more prevalent in older adults.

#### 3. Drug Interactions
The primary focus of drug interactions with IL36B typically revolves around drugs that target inflammatory pathways or cytokine signaling. Some associated drug classes or specific compounds include:
- **Biologics:** Such as monoclonal antibodies targeting IL-1 family members or IL-36R (e.g., NI-0101, a monoclonal antibody against IL-36R).
- **Corticosteroids:** Used for conditions involving excessive inflammation.
- **Non-Steroidal Anti-Inflammatory Drugs (NSAIDs):** These may influence pathways engaged by pro-inflammatory cytokines, including IL-36.

#### 4. Pathways and Biological Processes
IL36B is involved in several key biological pathways and processes, including:
- **Cytokine-mediated signaling pathways:** Where it plays a role in modulating both innate and adaptive immune responses.
- **Inflammation:** Contributes to tumor necrosis factor (TNF) signaling and interleukin-1 signaling pathways.
- **Chemoattraction:** Stimulates chemokines' production, attracting T-cells and other immune cells to sites of inflammation.
- **Antimicrobial responses:** Involvement in inducing antimicrobial peptides as part of epithelial barrier defense.
- **Cell proliferation and differentiation:** Influences keratinocyte behavior in skin tissues and potentially affects T-cell maturation.

The roles of IL36B in these processes underscore its importance in local and systemic inflammatory responses, particularly under pathological conditions or during aging-related changes in immune function.