**Gene Overview: ATP5MC1**

### 1. Associated Genes
The ATP5MC1 gene is associated with several other genes linked to mitochondrial function and ATP synthesis, including:
- **ATP5F1** (ATP synthase, F1 complex, beta subunit)
- **ATP5A1** (ATP synthase, F1 complex, alpha subunit)
- **ATP5H** (ATP synthase, F1 complex, epsilon subunit)
- **ATP5MC2** (a paralog also encoding subunit c of ATP synthase)
- **ATP5MC3** (another paralog encoding subunit c)
- Genes involved in mitochondrial biogenesis and dynamics, such as **PINK1**, **PARK2**, and others involved in mitochondrial function and energy metabolism.

### 2. Aging and Age-Related Diseases
The ATP5MC1 gene plays a pivotal role in mitochondrial function, which is closely linked to cellular bioenergetics and is thought to influence aging processes. Impaired mitochondrial function has been associated with several age-related diseases, including:
- **Mitochondrial myopathies**: dysfunction in ATP synthesis can lead to muscle weakness and neurodegenerative symptoms.
- **Neurodegenerative diseases**: such as Parkinson's and Alzheimer's disease, where mitochondrial dysfunction and reduced ATP production may contribute to cell death.
- **Cardiovascular diseases**: inadequate ATP production can affect cardiomyocyte function and energy supply in heart diseases.

### 3. Drug Interactions
While specific drugs targeting ATP5MC1 directly are not common, ATP synthase and associated pathways are influenced by various compounds such as:
- **Oligomycin**: a known inhibitor of ATP synthase, impacting mitochondrial ATP production.
- **Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)**: have been shown to affect mitochondrial function indirectly.
- Antioxidants: such as Coenzyme Q10 or Idebenone are used in contexts where mitochondrial function needs support, although these do not act specifically on ATP5MC1.

### 4. Pathways and Biological Processes
The ATP5MC1 gene is primarily involved in the following pathways and biological processes:
- **Oxidative phosphorylation**: ATP synthesis is linked with the electron transport chain in mitochondria.
- **Mitochondrial ATP synthesis**: necessary for various cellular processes requiring energy.
- **Regulation of energy production**: impacts metabolic pathways tied to energy demands in cells.
- **Intrinsic apoptotic signaling pathway**: energy status and mitochondrial transmembrane potential can influence apoptosis.

### Additional Notes
Given the critical role that ATP5MC1 plays in mitochondrial energy metabolism, ongoing research may explore its contributions to broader cellular bioenergetic states and links to diseases, particularly as our understanding of mitochondrial biology continues to grow in the context of aging and metabolic disorders.