### DOK3 Gene Overview

**Gene Symbol:** DOK3  
**Location:** Chromosome 17  
**Function:** The DOK3 gene is part of the DOK (Docking Proteins) family, which encodes adaptor proteins that play a significant role in intracellular signaling pathways. DOK3 is primarily characterized as an inhibitory regulator of signaling pathways, particularly in B-cells, where it negatively regulates c-Jun N-terminal kinase (JNK) through interactions with INPP5D (SHIP1).

### Associated Genes
DOK3 interacts with several other genes and proteins, including but not limited to:

1. **INPP5D (SHIP1)** - Involved in the negative regulation of B-cell receptor signaling.
2. **ABL1** - A non-receptor protein-tyrosine kinase associated with cellular signaling pathways.
3. **Ras proteins** - DOK3 is implicated in Ras signal transduction, although specific Ras family members directly associated with DOK3 might not be detailed.
4. Other DOK family members such as DOK1 and DOK2 might also exhibit interactions due to structural and functional similarities.

### Aging and Age-Related Diseases
While specific aging-related studies directly involving DOK3 may be limited, general insights into its function and implications can be surmised:

- **Immune Function:** Since DOK3 is implicated in B-cell signaling, changes in its expression or function could theoretically contribute to age-related changes in immune response, such as immunosenescence.
- **Cancer Research:** Given that DOK3 is linked to the regulation of various signaling pathways, alterations in its function may have implications in cancer biology, which is often associated with aging. Its role in the negative regulation of proliferation and survival pathways in B-cells suggests potential relevance in B-cell malignancies or lymphomas.
- **Neurodegenerative Disorders:** Since JNK has been associated with cellular stress responses and neurodegeneration, DOK3's role in modulating this pathway may also be of interest in the context of age-related neurodegenerative diseases.

### Drug Interactions
Currently, there are no specific drugs mentioned that interact directly with DOK3 itself. However, due to its role in various signaling pathways, it could be indirectly affected by drugs that target:

- **Targeted therapy in cancers** may alter ABL1 function, which DOK3 is known to modulate.
- **Immunomodulatory drugs** might influence B-cell signaling, potentially affecting DOK3 activity.

Research on pharmacological agents directly targeting DOK3 is limited, and any interactions would likely be gleaned from broader studies on the signaling pathways in which it operates.

### Pathways and Biological Processes
DOK3 is involved in several crucial biological processes and signaling pathways:

1. **Ras Protein Signal Transduction** - It functions within pathways that are activated by growth factors and play a critical role in cell proliferation, differentiation, and survival.
2. **Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway** - DOK3 acts downstream of various receptor tyrosine kinases, where it participates in signal transduction networks.
3. **Negative Regulation of JNK Signaling Pathway** - DOK3 inhibits JNK pathway activity, which is essential for regulating cell survival, apoptosis, and proliferation.
4. **Cellular Response to Growth Factor Stimuli** - The protein facilitates cellular responses to extrinsic growth factors.

In summary, DOK3 is an important regulatory protein in signaling pathways associated with B-cell function and broader cellular processes. Its interactions and regulatory roles might connect to various physiological and pathological conditions. Further research is needed to elucidate its full range of functions and implications in aging and diseases.