### RXRG Gene Overview

**Gene Symbol**: RXRG  
**Full Name**: Retinoid X receptor gamma

**General Function**: The RXRG gene encodes a member of the retinoid X receptor (RXR) family, which acts as a nuclear receptor that binds to retinoic acid, thyroid hormones, and vitamin D. These receptors function primarily as transcription factors, regulating gene expression in response to various ligands. RXRG forms dimers with other nuclear receptors, enhancing their DNA binding and transcriptional activity.

### 1. Associated Genes

While the summaries provided do not explicitly mention additional genes, RXRG is known to interact with the following:

- **RXRA** (Retinoid X receptor alpha)
- **RXRB** (Retinoid X receptor beta)
- **RARA** (Retinoic acid receptor alpha)
- **RARB** (Retinoic acid receptor beta)
- **RARG** (Retinoic acid receptor gamma)

These receptors form heterodimers with RXRG, which modulate gene expression.

### 2. Aging and Age-Related Diseases

The RXRG gene has been implicated in various biological functions that impact aging and age-related diseases:

- **Cancer**: RXRG expression is decreased in non-small cell lung cancer tissues, suggesting a potential role in tumor suppression.
- **Metabolic Regulation**: RXRG is associated with the regulation of metabolic processes, and disturbances in these pathways can be affiliated with age-related metabolic disorders.
- **Cardiovascular Health**: Altered expression of RXRG has potential implications for cardiovascular diseases, which are often exacerbated by aging.
- **Neurodegenerative Conditions**: Research suggests RXRs may have neuroprotective effects, implicating RXRG in the regulation of brain health and neurodegeneration with age.

### 3. Drug Interactions

Drugs and drug classes that are known to interact with the RXRG gene include:

- **Retinoids**: All-trans retinoic acid and 9-cis retinoic acid are natural ligands that activate RXRG, influencing various cellular processes.
- **Hormonal therapies**: RXRG may interact with drugs related to thyroid hormone and vitamin D signaling pathways.

Given the RXR's role in modulating transcription in response to these ligands, various synthetic retinoids used in clinical treatments for skin conditions or cancer may affect RXRG activity.

### 4. Pathways and Biological Processes

RXRG is involved in several key biological pathways and processes:

- **Retinoic Acid Signaling Pathway**: The activation of RXRG by retinoic acids leads to transcriptional regulation of genes involved in development, differentiation, and growth.
- **Thyroid Hormone Signaling Pathway**: RXRG participates in thyroid hormone receptor dimerization and plays a role in metabolism.
- **Vitamin D Signaling Pathway**: As with retinoic acid, RXRG forms heterodimers with vitamin D receptors to influence gene expression.
- **Cell Cycle Regulation**: The antiproliferative effects of retinoic acid, mediated through RXRG, impact cellular growth and differentiation, indicating a role in cell cycle regulation.

In summary, the RXRG gene is a critical component in various signaling pathways related to development, metabolism, and disease, with implications for aging and therapeutic interventions.