### FPGT Gene Summary

**Gene Symbol:** FPGT  
**Function:** The FPGT gene encodes a protein that plays a crucial role in the formation of GDP-beta-L-fucose, which is a key sugar in glycoconjugates. This pathway assists in the reutilization of L-fucose derived from the turnover of glycoproteins and glycolipids. The FPGT protein catalyzes the condensation of beta-L-fucose-1-phosphate with GTP to produce GDP-beta-L-fucose, functioning as a salvage pathway in certain mammalian tissues.

### Additional Associated Genes
The FPGT gene is located adjacent to the **TNNI3K** (TNNI3 interacting kinase) gene, with evidence of read-through transcription. Besides these, FPGT might be associated with genes involved in carbohydrate metabolism, glycosylation processes, and immune response, although specific genes outside those mentioned in the summaries need further literature review to identify.

### Aging and Age-Related Diseases
While specific associations between FPGT and aging or age-related diseases might not be explicitly documented, L-fucose and fucosylation processes are increasingly being recognized for their role in maintaining cellular homeostasis. Dysregulated glycosylation, including fucosylation, has implications in various age-related conditions, such as:
- **Cancer:** Abnormal fucosylation patterns have been observed in cancer cells, influencing tumor growth and metastasis.
- **Alzheimer's Disease:** Altered glycosylation profiles are implicated in neurodegenerative diseases, including Alzheimer's, where fucosylation can affect neuronal function and synaptic plasticity.

### Drug Interactions
Currently, detailed information about specific drugs or drug classes interacting directly with the FPGT gene or its product (the FPGT protein) is limited and may require more focused studies or drug interaction databases. However, drugs that affect glycosylation pathways or those targeting carbohydrate metabolism might indirectly influence FPGT activity.

### Pathways and Biological Processes
The FPGT gene is involved in several key biological processes, including, but not limited to:
- **Glycosylation:** The addition of sugar molecules to proteins, impacting protein folding, stability, and cell signaling.
- **Fucosylation Pathways:** Specifically, it contributes to the salvage pathway for L-fucose from glycoprotein and glycolipid turnover.
- **Metabolism of Carbohydrates:** It plays a role in the metabolism of carbohydrates by facilitating the conversion of L-fucose into its nucleotide sugar form, GDP-beta-L-fucose.
- **Cell-Cell Recognition:** By affecting the glycosylation status of glycoproteins, FPGT may influence cell adhesion and interactions.

Further research is necessary to elucidate more specific pathways that may involve FPGT directly, as well as its interactions beyond the known roles in GDP-fucose synthesis.