### DPYSL4 Gene Overview

**Gene Symbol:** DPYSL4

**Function:** The DPYSL4 gene encodes a protein that enables filamin binding activity, which is important for the structure and signaling cascades associated with the cytoskeleton. It is primarily involved in nervous system development, playing roles in axon guidance, neuronal growth cone collapse, and cellular migration. The protein is predicted to be located in the cytosol and is thought to be necessary for signaling by class 3 semaphorins, which are critical for neuronal patterning and guidance.

### 1. Associated Genes:
While the summary provided does not specify associated genes, related genes involved in similar pathways or functions include:
- **DPYSL2 (Dihydropyrimidinase-Like 2)**
- **DPYSL3 (Dihydropyrimidinase-Like 3)**
- **SEMAPHORIN genes (e.g., SEMA3A, which is involved in axon guidance)**

These genes all influence neuronal development and cytoskeletal dynamics, and interact with pathways involving semaphorins and filamin.

### 2. Aging and Age-Related Diseases:
Current research links DPYSL4 with several aspects of neurodegeneration and aging:
- **Neurodegenerative Diseases:** Abnormalities or dysregulation in DPYSL4 expression might contribute to conditions such as Alzheimer's disease and other forms of dementia, given its role in neuronal signaling and cytoskeletal integrity.
- **Aging:** Studies have suggested potential roles of DPYSL4 in maintaining neuronal function in aging, as well as implications in the decline of synaptic plasticity and function associated with aging.

### 3. Drug Interactions:
There is limited information about specific drugs that directly target or interact with DPYSL4. However, given its role in neuronal signaling, it could potentially be influenced indirectly by:
- **Neuroprotective compounds**, which may help in maintaining cytoskeletal integrity or improve signaling pathways in neurodegenerative diseases.
- **Drugs affecting semaphorin signaling**, although specific interactions are not well-documented.

### 4. Pathways and Biological Processes:
DPYSL4 is involved in several critical biological processes, including:
- **Axon guidance:** Essential during neuronal development to guide growing axons to their targets.
- **Semaphorin signaling pathway:** Involvement in the response to semaphorins, influencing cell migration and neuronal development.
- **Cytoskeleton organization:** DPYSL4 participates in remodeling of the cytoskeleton, which is crucial for maintaining neuronal structure and function.
- **Neuronal growth cone collapse:** An important mechanism in neuronal development and synaptic plasticity.
- **Cell migration:** Influences cellular processes during development and possibly in disease progression.

### Conclusion:
In summary, DPYSL4 is a multifaceted gene essential for proper nervous system development and function. Its interactions with various pathways and its potential implications in aging and neurodegenerative diseases provide a significant focus for ongoing research efforts. While there is limited information on specific drugs affecting DPYSL4, its role in neuronal health underscores the importance of further investigation into its functions and potential therapeutic targets.