**ABHD15 Gene Overview**

- **Gene Symbol:** ABHD15
- **Function:** The ABHD15 gene is predicted to have acylglycerol lipase activity and short-chain carboxylesterase activity, suggesting a role in lipid metabolism. It is located in cellular membranes and is thought to be involved in the regulation of lipid homeostasis, particularly in adipocytes and liver tissues.

### 1. Associated Genes:
The ABHD15 gene is part of the lipase family, which includes other genes involved in lipid metabolism. Some related genes may include:

- **ABHD12:** Involved in the metabolism of brain lipids and is important in neurological function.
- **ATGL (PNPLA2):** Plays a critical role in the mobilization of stored triacylglycerol in adipose tissue.
- **HSL (Hormone-sensitive lipase):** Also involved in lipid mobilization in adipocytes.
- **PLA2 (Phospholipases A2):** Participates in the hydrolysis of phospholipids.

### 2. Aging and Age-Related Diseases:
Although specific direct associations of ABHD15 with aging or age-related diseases are not extensively documented, its role in lipid metabolism has implications:

- **Metabolic Syndrome and Obesity:** Since ABHD15 is involved in regulating lipid accumulation and lipolysis in adipocytes, dysfunctions may contribute to obesity, a condition often correlated with aging and metabolic syndrome.
- **Non-Alcoholic Fatty Liver Disease (NAFLD):** Altered lipid metabolism, including that mediated by ABHD15, may influence the development of NAFLD, which has increased incidence with age.

### 3. Drug Interactions:
As of my last knowledge update, there are no specific drugs or drug classes directly associated with the ABHD15 gene. However, fatty acid metabolism pathways may be influenced by drugs that target lipid metabolism, such as:

- **Thiazolidinediones (TZDs):** Insulin sensitizers that impact fatty acid metabolism.
- **Fibrates:** Drugs that primarily promote triglyceride clearance and modulate lipid levels.
- **Statins:** These primarily target cholesterol metabolism, but can also have downstream effects on lipid profiles.

### 4. Pathways and Biological Processes:
ABHD15 is implicated in a variety of biological processes, including:

- **Lipid Metabolic Process:** It is involved in the regulation of lipid breakdown and synthesis.
- **Adipocyte Lipolysis:** May play a role in the mobilization of stored lipids in adipose tissues.
- **Liver Lipid Accumulation:** Regulation of lipid storage dynamics in the liver.

The gene may also participate in several metabolic pathways, including:

- **Glycerophospholipid metabolism:** Which involves the breakdown and synthesis of glycerolipids.
- **Fatty acid metabolic processes:** Modulating the degradation and synthesis of fatty acids.

In conclusion, while ABHD15 has recognized functions with predictive associations to metabolic processes, further research is necessary to elucidate its precise roles and interactions in health and disease, particularly concerning aging and therapeutic targeting.