### TSSC4 Gene Overview

**Gene Symbol:** TSSC4  
**Location:** Chromosome 11p15.5  
**Function:** Tumor suppression and spliceosomal assembly 

#### 1. Associated Genes:
In addition to TSSC4, several other genes located in the imprinted domain of 11p15.5 include:
- **IGF2** (Insulin-like Growth Factor 2)
- **H19**
- **KCNQ1**
- **CDKN1C** (Cyclin-dependent kinase inhibitor 1C)
- **MEST** (Methylated in the embryonic stem cells)

These genes are often studied in the context of genomic imprinting, cancer predisposition, and specific syndromes, such as Beckwith-Wiedemann syndrome. 

#### 2. Aging and Age-Related Diseases:
While there are no direct studies specifically linking TSSC4 to aging or age-related diseases, its role in tumor suppression indicates it may contribute indirectly to age-related cancer susceptibility. Tumor suppressor genes often exhibit altered expression in age-related cancers. Further research may clarify any potential age-related expression changes or interactions with aging pathways.

#### 3. Drug/Drug Classes Interacting with TSSC4:
Currently, specific drugs directly targeting TSSC4 have not been extensively documented in the literature. However, due to its involvement in spliceosomal assembly, compounds that influence splicing and related pathways, such as:
- **Anticancer agents** (like splicing modulators)
- **Histone deacetylase inhibitors** (HDACi) 
- **Chemotherapeutic agents** (like taxanes or platinum compounds that may affect gene expression)

may indirectly interact through their effects on pathways relevant to TSSC4's biological functions.

#### 4. Pathways and Biological Processes Involved:
- **Molecular splicing pathways:** TSSC4 is involved in the U5 snRNP maturation and recycling post-splicing, essential for spliceosomal dynamics.
- **RNA splicing:** It plays a role in the tri-snRNP complex assembly, facilitating proper mRNA splicing and processing.
- **Tumor suppression pathways:** Given its location in a key tumor-suppressor region, it may be implicated in various tumorigenesis pathways related to suppressing uncontrolled cell growth.
- **Imprinting control mechanisms:** Associated with the regulation of imprinted genes, impacting various developmental processes.

### Conclusion:
TSSC4 is a gene of significant interest in cancer biology, particularly in the context of tumor suppression and splicing mechanisms. Its connections to other imprinted genes at 11p15.5 enhance its relevance in developmental disorders and malignancies. Further research into TSSC4's role in aging and pharmacological interactions may provide additional insights into its significance in cancer prevention and treatment.