### MANSC4 Gene Overview

**Gene Symbol:** MANSC4  
**Predicted Function:** MANSC4 (Mannosyl-oligosaccharide 1,2-alpha-mannosidase) is predicted to be an integral component of the membrane, implicating a role in cellular processes such as glycoprotein synthesis and maturation.

### 1. Associated Genes
While specific associations are typically determined through co-expression and interaction studies, other genes that may be related to MANSC4, based on functional pathways and biological processes, include:

- **MANSC1:** A closely related gene that is also involved in protein glycosylation.
- **MAN2A1:** This gene encodes a mannosidase involved in the degradation of complex carbohydrates.
- **Mannosyltransferases** like **MOGS** and **ALG3** may also be relevant in the context of protein maturation and glycosylation processes.

### 2. Aging and Age-related Diseases
Research explicitly linking MANSC4 to aging or specific age-related diseases is limited. However, given its role in glycosylation, alterations in mannosidases have been associated with:

- **Age-related cognitive decline:** Glycosylation patterns shift with age, potentially impacting protein functions critical for neuronal health.
- **Neurodegenerative diseases:** Misfolded proteins and altered glycosylation are implicated in diseases such as Alzheimer’s, where proper function of glycoproteins is essential.
- **Metabolic disorders:** Impairments in glycosylation have been linked with conditions like diabetes, often exacerbated with age.

Further research is necessary to explicitly connect MANSC4 with these processes.

### 3. Drug Interaction
As of the latest data:

- There are currently no well-established drugs or drug classes directly known to interact with MANSC4. However, drugs targeting glycosylation processes or mannosidase inhibitors could potentially influence pathways where MANSC4 is involved.

### 4. Pathways and Biological Processes
MANSC4 is believed to be involved in several biological processes, including but not limited to:

- **Protein glycosylation:** A critical post-translational modification affecting protein folding and stability.
- **Cellular response to stress:** Alterations in glycosylation can influence how cells respond to various stressors.
- **Developmental processes:** As with many glycosylation-related genes, MANSC4 may play a role in embryonic development and cell differentiation processes.
- **Endoplasmic reticulum-associated degradation (ERAD):** Given its role in glycosylation, it may influence the quality control mechanisms in the ER.

### Summary
MANSC4 is a gene of increasing interest, especially concerning its functional role in glycosylation and potential implications in aging and neurodegeneration. However, explicit links to specific drugs and age-related diseases require further empirical studies for validation.