### NME3 Gene Overview

**Gene Symbol**: NME3  
**Function**: The NME3 gene encodes a protein predicted to have nucleoside diphosphate kinase activity. It plays a significant role in synthesizing nucleoside triphosphates other than ATP through a unique ping-pong mechanism. This enzyme is believed to inhibit granulocyte differentiation and promote apoptosis, suggesting its importance in hematopoiesis.

### 1. Associated Genes
While specific associations can depend on studies and context, NME3 has been linked to other genes involved in similar metabolic processes or pathways. Notable genes might include:
- **NME1**
- **NME2** 
- **NME4**  
These genes are part of the NME (NME/NM23) gene family and share functional similarities, especially concerning their roles in nucleoside triphosphate metabolism and cellular processes.

### 2. Age-Related Associations
While specific studies directly correlating NME3 with aging or age-related diseases may not be extensively detailed, related pathways involving apoptosis and hematopoiesis are known to influence aging. Dysregulation of apoptosis and hematopoietic functions can contribute to age-related pathologies, including cancer. Alterations in NME3 function or expression may also be reflected in age-related shifts in granulocyte differentiation, impacting immune response efficiency in the elderly.

### 3. Drug and Drug Class Interactions
There may not be specific drugs directly targeting NME3; however, since the protein is involved in nucleotide metabolism, drugs affecting nucleoside metabolism or DNA synthesis, such as chemotherapeutic agents, could indirectly influence NME3 activity. Common drug classes that may interact with pathways involving NME3 include:
- **Antineoplastic agents**: Such as purine analogs (e.g., Mercaptopurine).
- **Nucleotide analogs**: These may impact processes related to the synthesis of nucleotides.

### 4. Pathways and Biological Processes
NME3 is involved in several critical biological processes, including but not limited to:
- **Apoptotic Process**: Induction of apoptosis, which is critical for eliminating damaged or unnecessary cells.
- **Nucleotide Metabolic Process**: Contributing to the synthesis and metabolism of nucleotides, paramount for DNA/RNA synthesis during cell growth and division.
- **Cell Growth and Differentiation**: Particularly in hematopoiesis, where it's suggested to inhibit the differentiation of certain cells while promoting programmed cell death when necessary.
  
### Conclusion
NME3 is a multifaceted gene playing a critical role in nucleotide metabolism, with potential implications in aging and related diseases. Its interactions with other NME family members and potential indirect relationships with drug metabolism make it a notable gene for further exploration in research contexts. Further studies should focus on clarifying its role in vitro and in vivo to elucidate its therapeutic potential and relevance in diseases.