The TUBA3D gene, also known as Tubulin Alpha 3D, encodes a member of the alpha tubulin family, which is integral to the structure and function of microtubules within the cytoskeleton. Microtubules play crucial roles in maintaining cellular architecture, intracellular transport mechanisms, and ensuring proper spindle formation during mitosis.

### Additional Information on TUBA3D Gene:

1. **Associated Genes**:
   - While specific genes associated with TUBA3D are not typically detailed in gene summaries, generally, other tubulin family genes (e.g., TUBA1A, TUBB, TUBB2A, TUBB3) may be related due to their involvement in microtubule dynamics and regulation. Moreover, genes involved in microtubule-associated protein complexes (such as MAP1A, MAP2) or pathways that regulate cytoskeleton organization and dynamics may also relate to TUBA3D's function.

2. **Aging and Age-Related Diseases**:
   - Microtubule dynamics undergo changes with aging, and dysregulation of tubulin function has been implicated in a variety of age-related diseases including neurodegenerative disorders (e.g., Alzheimer’s Disease), where microtubule stability and function are compromised. Mutations or dysregulation in tubulin proteins, including those encoded by TUBA3D, can lead to pathological conditions that affect cellular transport and signaling, exacerbating age-related degeneration.

3. **Drug Interactions**:
   - TUBA3D and the associated tubulin proteins are targets for various pharmacological agents, particularly in cancer therapy. Notable drug classes that interact with tubulin include:
     - Vinca alkaloids (e.g., vincristine, vinblastine), which inhibit microtubule assembly.
     - Taxanes (e.g., paclitaxel, docetaxel), which stabilize microtubules and prevent their depolymerization.
     - Other compounds and investigational drugs that disrupt microtubule dynamics could also impact TUBA3D effectively.

4. **Pathways and Biological Processes**:
   - The TUBA3D gene is involved in several critical biological processes, including:
     - Microtubule assembly and disassembly, crucial for cellular structure and mobility.
     - Mitotic spindle formation and chromosome segregation during cell division.
     - Intracellular transport mechanisms, influencing the trafficking of organelles and proteins.
     - Signal transduction pathways that may involve microtubule-associated proteins (MAPs) and the broader cytoskeletal network.

In conclusion, TUBA3D plays a vital role in cellular architecture and function, impacting various physiological processes and having implications in aging and disease contexts. Understanding its interactions and pathways may be critical for exploring therapeutic targets, especially in age-related and cancerous conditions.