The **ARHGEF9-IT1** gene is a long non-coding RNA (lncRNA) that is known to play roles in various biological processes, though its precise functions are still being investigated. Here’s a detailed overview of the gene based on the requested information:

### 1. Associated Genes
While specific associations might not be fully detailed in the summaries provided by NCBI and UniProt, lncRNAs typically have interactions or regulatory roles involving several protein-coding genes and pathways. Some of the genes that have been associated with ARHGEF9-IT1 may include:

- **ARHGEF9** (the gene from which ARHGEF9-IT1 is derived): This gene encodes a guanine nucleotide exchange factor that is involved in signaling pathways related to cytoskeletal dynamics.
- **Rho family GTPases**: Genes like RHOA, RHOB, and RAC1 could be indirectly associated due to their roles influenced by ARHGEF9.
- Additional gene sets that participate in neurological functions or cancer may also interact in various contexts.

Research into the specific gene interactions of ARHGEF9-IT1 is ongoing, and new relationships may emerge as additional studies are conducted.

### 2. Aging and Age-Related Diseases
The involvement of lncRNAs in aging and age-related diseases is an emerging field of research. While specific studies on ARHGEF9-IT1 may be limited, lncRNAs like it can modulate gene expression in ways that impact cellular senescence, stress responses, and inflammation. 

- **Potential association with neurodegenerative diseases**: Since ARHGEF9 is involved in synaptic function, alterations in its expression or regulation through ARHGEF9-IT1 could influence disorders like Alzheimer's disease, which are characterized by age-related degeneration of synapses and alterations in cellular signaling.

- **Cancer**: Some evidence may suggest a correlation between lncRNA expressions and outcomes in various cancers, positioning ARHGEF9-IT1 as a potential player in cancer biology linked to aging.

### 3. Drug Interactions
To date, specific drug interactions directly involving ARHGEF9-IT1 have not been extensively characterized. However, since its encoded proteins influence pathways that are targeted by various cancer therapies, potential indirect effects on how drugs may work cannot be ruled out. Drugs that target **Rho GTPase signaling** or pathways involving **cell mobility and adhesion** may be particularly relevant in this regard. 

### 4. Pathways and Biological Processes
ARHGEF9-IT1 is believed to be involved in multiple pathways and biological processes:

- **Cell Signaling Cascades**: Particularly those involved in neurodevelopment and synaptic plasticity, influenced by its association with ARHGEF9.
- **Cytoskeletal Dynamics**: As a guanine nucleotide exchange factor, ARHGEF9 participates in the regulation of the actin cytoskeleton, which is critical for various cellular functions including migration and adhesion.
- **Neural Development and Function**: Potential roles in brain development and the maintenance of synaptic integrity.
- **Regulatory Roles in Gene Expression**: As a long non-coding RNA, ARHGEF9-IT1 might be involved in epigenetic regulation and the modulation of neighboring gene expression.

### Conclusion
ARHGEF9-IT1 is an intriguing gene entity within the broader context of gene regulation, particularly in relation to neurobiology and potentially in aging. As the study of long non-coding RNAs continues to evolve, further functional validations and discoveries regarding ARHGEF9-IT1 and its scope of influence will likely yield new insights into health and disease.