### LRRC14 Gene Overview

**Gene Symbol:** LRRC14  
**Gene Type:** Protein-coding gene  
**Chromosomal Location:** Human chromosome 14 (14q11.2)  
**Function:** Encodes a leucine-rich repeat-containing protein that is involved in the regulatory mechanisms of immune signaling.

### Detailed Information 

#### 1. Associated Genes:
While specific genes directly associated with LRRC14 may vary, the interactions noted in relevant literature can include:
- **IKBKB (IKK beta):** Direct interaction, as LRRC14 disrupts IKK core complex formation.
- Additional genes involved in the NF-kappa-B signaling pathway may also be relevant, including:
  - **NFKB1**
  - **TLRs (Toll-like receptors) such as TLR2, TLR4, etc.**
- **IKBKG (NEMO):** As part of the IKK complex.
  
These associations help elucidate the role of LRRC14 in immune signaling.

#### 2. Aging and Age-related Diseases:
Current research does not provide extensive direct links between LRRC14 and aging or specific age-related diseases, but regulatory roles in immune signaling suggest potential involvement in:
- **Chronic inflammation:** As immune responses often shift with age, LRRC14's role in regulating NF-kappa-B could imply involvement in age-related chronic inflammatory conditions.
- **Neurological Diseases:** Some studies suggest that aberrant NF-kappa-B signaling could be implicated in neurodegeneration, which is often linked to aging.

Further investigation and studies are required to ascertain direct connections to aging disorders or specific diseases.

#### 3. Drug Interactions:
As of my last knowledge update, specific drug interactions with LRRC14 were not well-characterized. However:
- **Immunomodulatory Drugs:** Given LRRC14’s role in regulating immune responses and signaling pathways, certain immunomodulators could potentially influence its function, but specifics need validation through experimental research.
- **TLR Agonists/Antagonists:** Since LRRC14 interacts with TLR pathways, treatments involving TLR modulation could also indirectly affect LRRC14 activity.

#### 4. Pathways and Biological Processes:
LRRC14 is implicated in several biological processes and signaling pathways, mainly:
- **Negative Regulation of NF-kappa-B Signaling:** LRRC14 interferes with the formation of the IKK complex involved in this critical signaling pathway.
- **Immune Response:** Plays a role in modulating responses to pathogen-associated molecular patterns through TLRs.
- **Cellular Response to Stress:** Involved in pathways regulating cellular stress responses, potentially contributing to survival during inflammatory states.

Additional pathways where LRRC14 might be involved need to be explored through further functional assays and genetic studies to confirm broader biological roles.

### Summary
The LRRC14 gene encodes a protein that is crucial in the immune signaling cascade by acting as a negative regulator of the NF-kappa-B signaling pathway. Its interactions with specific proteins highlight its importance in immune regulation, although further research is necessary to elucidate its role in aging and potential drug interactions.