### THBS3-AS1 Gene Overview

**Gene Symbol**: THBS3-AS1  
**Location**: Human chromosome 5

THBS3-AS1 (Thrombospondin 3 Antisense RNA 1) is a long non-coding RNA (lncRNA) that is transcribed from the reverse strand of the THBS3 gene. Long non-coding RNAs like THBS3-AS1 play critical roles in the regulation of gene expression and several biological processes by interacting with chromatin, RNA, and proteins.

### 1. Associated Genes
While the summaries from NCBI and UniProt may not detail specific associated genes, THBS3-AS1 is often associated with genes that are involved in vascular and cellular processes due to its relation to thrombospondin, such as:
- **THBS3**: The sense strand, directly related to its antisense RNA counterpart.
- Other thrombospondin family members (like **THBS1, THBS2**) and various signaling or transcription factors that may interact with lncRNAs.

### 2. Aging and Age-Related Diseases
Research indicates that long non-coding RNAs like THBS3-AS1 may have implications in aging and age-related diseases. For instance, lncRNAs can modulate pathways related to cellular senescence, apoptosis, and inflammation—all of which are crucial aspects affecting aging. While there isn’t a plethora of specific studies linking THBS3-AS1 to aging directly, alterations in lncRNA profiles have been observed in age-related conditions, such as:
- Cardiovascular diseases
- Neurodegenerative disorders
- Cancer
Insights into these associations warrant further investigation into THBS3-AS1's specific roles in such diseases and its potential as a biomarker or therapeutic target.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes directly known to interact with THBS3-AS1. However, drugs targeting pathways associated with thrombospondins or broader inflammatory responses may indirectly modulate the expression or function of this lncRNA. It would be important to rely on emerging literature and experimental findings for any novel interactions that may be elucidated.

### 4. Pathways & Biological Processes
THBS3-AS1 has been implicated in various biological processes and pathways although specific annotations may depend on current research. Potential areas of involvement include:
- **Regulation of Gene Expression**: Functioning through epigenetic modifications or competing for binding to transcriptional machinery.
- **Cellular Processes**: Possibly contributing to cellular adhesion, migration, and proliferation due to its association with the thrombospondin family.
- **Vascular Biology**: Given its connection to thrombospondins, it might be involved in processes like angiogenesis and vascular remodeling.
- **Pathways**: Further investigation may reveal associations with signaling pathways such as TGF-beta signaling which are crucial in fibrosis and inflammation.

### Summary
The THBS3-AS1 gene represents an important target in the study of lncRNAs. While it has a functional basis related to thrombospondins, it could have important roles in aging and associated disorders, although much remains to be clarified in terms of direct associations, drug interactions, and specific pathways in ongoing research. As this field advances, continued exploration into THBS3-AS1 could reveal significant therapeutic and diagnostic implications.