### PEX14 Gene Overview

**Gene Symbol**: PEX14  
**Location**: Chromosome 1

**Function**: The PEX14 gene encodes a protein that is an essential component of the peroxisomal import machinery. The encoded protein is integral to the peroxisomal membrane and plays a crucial role in mediating the import of peroxisomal proteins that contain a peroxisomal targeting signal (PTS1). PEX14 participates in the formation of the PEX13-PEX14 docking complex, which works in conjunction with the PEX5 receptor to facilitate the import of these proteins into the peroxisome.

### 1. Associated Genes

While the summaries provided mention PEX5 and PEX13, PEX14 has associations with several other peroxin genes involved in peroxisome biogenesis and function, including:

- **PEX1**: Mutations in PEX1 can lead to X-linked adrenoleukodystrophy and other peroxisomal disorders.
- **PEX2**, **PEX3**, **PEX6**, **PEX19**, **PEX26**: These genes also encode proteins involved in peroxisome formation, import, and metabolism.

### 2. Aging and Age-Related Diseases

PEX14 is associated with Zellweger Syndrome, which is part of a group of disorders known as peroxisome biogenesis disorders (PBDs). These disorders can lead to accelerated aging features and neurodegenerative aspects due to impaired lipid metabolism and the accumulation of very-long-chain fatty acids (VLCFAs), which can adversely affect cellular functions. Alterations in peroxisomal function due to PEX14 dysregulation can contribute to age-related diseases such as Alzheimer’s and other neurodegenerative disorders, although more direct evidence is still under investigation.

There is ongoing research regarding the role of peroxisomes in oxidative stress response and aging, suggesting that PEX14, through its role in protein import and peroxisome integrity, could influence longevity and the aging process indirectly.

### 3. Drug Interactions

Currently, there are no specific drugs known to directly interact with the PEX14 gene or its protein product in clinical practice. However, due to the gene's involvement in metabolic pathways, certain classes of drugs that target peroxisomal function may indirectly influence PEX14 activity, such as:

- **Fibrates**: These are lipid-regulating agents that may have effects on peroxisomal functions and PPAR (peroxisome proliferator-activated receptor) signaling.

### 4. Pathways and Biological Processes

PEX14 is involved in several critical biological processes and pathways, including:

- **Peroxisome biogenesis**: Plays a crucial role in the assembly and function of peroxisomes.
- **Protein targeting to peroxisomes**: Mediates the import of proteins with PTS1, a crucial step in peroxisome protein targeting.
- **Endoplasmic reticulum-associated degradation (ERAD)**: Some evidence suggests it may play a role in protein quality control mechanisms that link with the endoplasmic reticulum and degradation pathways.
- **Cellular oxidative stress response**: Participates in pathways that mitigate oxidative damage via its involvement in peroxisomal metabolism.
- **Microtubule-based processes**: PEX14 interacts with tubulin, which is integral for peroxisome movement and positioning within cells.

### Conclusion

PEX14 is a vital gene with essential functions in peroxisome biology. Its role in peroxisomal import and associated diseases underscores its significance in cellular metabolism and potential implications for age-related conditions. Further research could unveil additional aspects of its function, interactions, and clinical relevance.