### FBXO17 Gene

**General Overview:**
The FBXO17 gene encodes a member of the F-box protein family, which is an integral part of the ubiquitin-proteasome system, specifically serving as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. It is involved in the ubiquitination process, which regulates protein degradation, and plays a crucial role in various cellular processes by marking substrates for proteasomal degradation in a phosphorylation-dependent manner.

### 1. Associated Genes:
While the provided summaries mention the role of FBXO17 in the SCF complex, specific additional genes commonly associated with FBXO17 include:
- **SKP1 (S-phase kinase-associated protein 1)**: Part of the SCF ubiquitin ligase complex.
- **CUL1 (Cullin 1)**: Another component of the SCF complex.
- **UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1)**: May interact with pathways that include FBXO proteins.

### 2. Aging and Age-Related Diseases:
FBXO17 has been implicated in various biological processes that are relevant to aging and age-related diseases, such as:
- **Cellular Senescence**: Alterations in protein ubiquitination pathways, including those involving FBXO17, can affect cellular senescence and accumulation of senescent cells, which are linked to aging.
- **Cancer**: Dysregulation of FBXO17 has been observed in several cancer types, suggesting a role in tumorigenesis, and mutations or alterations in FBXO17 expression may contribute to the aging phenotype by affecting the stability of oncogenic drivers or tumor suppressors as cells age.

### 3. Drug Interactions:
While specific drugs directly targeting FBXO17 may not be well-documented, FBXO17's role in pathways associated with cancer and cellular stress suggests potential interactions with:
- **Proteasome inhibitors** (e.g., Bortezomib) which target the larger context of the proteasome, potentially affecting pathways involving FBXO17.
- Drugs in the field of pharmacology targeting E3 ligases for cancer therapy may also indirectly affect FBXO17.

### 4. Pathways and Biological Processes:
FBXO17 is involved in multiple cellular pathways and biological processes, including:
- **Ubiquitin-dependent protein catabolism**: It plays a significant role in tagging proteins for degradation via the ubiquitin-proteasome pathway.
- **Regulation of protein levels** in various signaling pathways critical for cell growth, division, and differentiation.
- **Immune response modulation**: Its interactions with proteoglycans and glycoproteins suggest potential roles in the immune system.
- **Response to cellular stress**: Indicating a role in regulating protein homeostasis under stress conditions.

### Summary:
FBXO17 is a critical component of the ubiquitin-proteasome system with implications in various regulatory systems, including aging and cancer. Its associated pathways and interactions with genes from the SCF complex underscore its importance in fundamental cellular processes, suggesting avenues for future research, especially concerning therapeutics that regulate ubiquitination in aging and diseases.