The MATN1-AS1 gene is an antisense long non-coding RNA (lncRNA) that is associated with the MATN1 gene, which encodes the protein matrilin-1, a component of the extracellular matrix.

### Additional Gene Associations
MATN1-AS1 is primarily linked with the following gene:
- **MATN1**: The MATN1 gene encodes the matrilin-1 protein which plays a role in cartilage and may have implications in skeletal development. There may be additional indirect associations with genes involved in connective tissue disorders, extracellular matrix (ECM) composition, or those that are regulated by lncRNAs in general, but specific genes were not noted in the standard references.

### Aging and Age-Related Diseases
There is some evidence suggesting that lncRNAs, including MATN1-AS1, may play roles in aging and age-related conditions. Although specific studies are limited, lncRNAs have been implicated in processes such as cellular senescence, regulation of inflammation, and fibrosis, which are all relevant in the context of aging and diseases such as osteoarthritis and other degenerative disorders related to the extracellular matrix. Further research is needed to establish a clear and direct relationship between MATN1-AS1 and specific age-related diseases.

### Drug Interactions
Currently, there are no specific drugs or drug classes that have been explicitly documented to interact with MATN1-AS1. As MATN1-AS1 is a long non-coding RNA, direct pharmacological targeting is less common than with protein-coding genes. However, it is worth noting that treatments targeting pathways involved in ECM remodeling might indirectly relate to the functions of MATN1-AS1.

### Pathways and Biological Processes
MATN1-AS1 is involved in several key biological processes:
- **Regulation of Gene Expression**: As a long non-coding RNA, MATN1-AS1 may play a role in modulating the expression of its sense gene (MATN1) as well as other genes through various mechanisms, such as chromatin remodeling and recruitment of transcriptional regulators.
- **Extracellular Matrix Organization**: Given its involvement with the MATN1 gene, MATN1-AS1 may also play a role in processes related to extracellular matrix organization and maintenance, which are critical in tissue integrity and cellular interactions.
- **Cellular Responses to Stress**: Some lncRNAs are known to be involved in cellular stress responses, which can be linked to age-related conditions and diseases.

In summary, while MATN1-AS1 is primarily characterized as an antisense lncRNA related to the MATN1 gene, more robust research is needed to fully elucidate its specific functions, interactions with drugs, and implications in aging and diseases.