### ADH5P3 Gene Overview

**Gene Symbol:** ADH5P3  
**Description:** The ADH5P3 gene is a pseudogene located on chromosome 4, designated mainly as a member of the alcohol dehydrogenase (ADH) gene family. While specific functional attributes in humans are limited due to its pseudogene status, related genes in the ADH family encode enzymes responsible for the metabolic conversion of alcohols and aldehydes, playing critical roles in various metabolic pathways.

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### 1. Associated Genes

- **ADH5 (Alcohol Dehydrogenase 5):** This is the most directly associated functional gene within the alcohol dehydrogenase family, which ADH5P3 is related to.
- **ADH1B, ADH1C:** Other alcohol dehydrogenase family members that interact with ADH5 and have been studied for their roles in alcohol metabolism.
- **CYP2E1:** Although not directly associated with ADH5P3, it is involved in ethanol metabolism and may influence pathways where ADH functions take place.

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### 2. Aging and Age-Related Disease Associations

Though specific studies targeting ADH5P3 are scarce because it is a pseudogene, its functional relatives, particularly the ADH family members, have been implicated in:

- **Alcohol Metabolism:** With aging, the body's ability to metabolize alcohol alters, potentially increasing susceptibility to alcoholic liver disease and other metabolic disorders.
- **Oxidative Stress:** Age-related changes in the metabolism of alcohol may escalate oxidative damage, a contributor to various age-related diseases (e.g., neurodegenerative diseases).
- **CARDIOVASCULAR DISEASES:** Genetic variations in alcohol dehydrogenase relatives have been associated with cardiovascular disease risks in older populations, hinting at indirect connections with age-related outcomes.

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### 3. Drug or Drug Class Interactions

Currently, there are no specific drugs directly associated with ADH5P3 due to its pseudogene status. However, drugs and compounds that target the wider ADH family (particularly ADH5) or affect alcohol metabolism can indirectly be considered:

- **Disulfiram (Antabuse):** Used to treat chronic alcoholism by inhibiting aldehyde dehydrogenase, thus increasing acetaldehyde levels when alcohol is consumed.
- **Fomepizole (Antizol):** An alcohol dehydrogenase inhibitor used in instances of methanol or ethylene glycol poisoning.

These drugs act upon pathways where ADH enzymes, including the family member ADH5, exert their influence.

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### 4. Pathways and Biological Processes

ADH5P3 itself does not contribute directly to biological processes, but the following pathways are significant for its functional relatives (ADH5 and family):

- **Ethanol metabolism pathway:** Converts ethanol to acetaldehyde and further to acetic acid, involving several ADH enzymes.
- **Detoxification pathways:** Through the metabolism of alcohols and aldehydes, these pathways help in detoxifying potentially harmful substances.
- **Oxidative phosphorylation:** Implications from ethanol metabolism can affect energy production and redox states within cells.

### Conclusion

While **ADH5P3** is primarily recognized as a pseudogene, its connections to related alcohol dehydrogenases and the biological processes influenced by these relatives underscore its relevance in metabolic pathways, aging, and disease susceptibility. Further studies in the context of genetic variations among the ADH family could provide more insight into the implications of ADH5P3 in human health.