The ROGDI gene, also known as "Rogdi (Kohlschutter-Tonz syndrome)," is important for normal brain development, neurogenesis, and odontogenesis, specifically in forming dentin in teeth. Its localization at the nuclear envelope and its presence at presynaptic sites on axons underscore its potential role in neuronal communication and connectivity.

### 1. Associated Genes
While specific associated genes may not be explicitly listed in the summaries provided from NCBI and UniProt, ROGDI has been implicated with several other genes based on its involvement in Kohlschutter-Tonz syndrome and neurodevelopmental contexts. Notable associations could include:

- **KHSRP** (KH-type splicing regulatory protein): Involved with RNA processing, which might be affected in scenarios related to ROGDI.
- **SYN2** (Synapsin II): Related to neurotransmitter release, potentially linking to the synaptic presence of ROGDI.
- **BCL11A**: Associated with various neurogenesis pathways.
  
Research into ROGDI's molecular interactome may reveal more gene associations, particularly through experimental studies or databases emphasizing protein-protein interactions.

### 2. Aging and Age-Related Diseases
Currently, there is no extensive research directly linking ROGDI to aging or specific age-related diseases. However, since it is involved in neurogenesis, its dysregulation could potentially influence neurodegenerative diseases or cognitive decline in aging. The expression levels or functionality of genes involved in presynaptic development and stability often correlate with neurodegenerative processes, warranting investigation into how ROGDI's function might vary over time or in age-related contexts.

### 3. Drug Interactions
At present, there are no specific drugs or drug classes confirmed to interact directly with ROGDI. However, due to its role in neuronal functions and presynaptic sites, any neuroactive drugs that affect synaptic transmission, neuronal health, or developmental pathways may indirectly interact with the pathways involving ROGDI.

### 4. Pathways and Biological Processes
ROGDI is involved in several biological processes and pathways:

- **Neurogenesis**: Critical for the proper formation of neural cells and connections during brain development.
- **Odontogenesis**: Involved in the development of teeth, particularly in the formation of dentin.
- **Regulation of Gene Expression**: As ROGDI localizes to the nuclear envelope, it may participate in regulating transcription in response to various cellular signals.
- **Presynaptic Function**: Elucidated by its presence at axonal presynaptic sites, ROGDI may be associated with pathways regulating synaptic vesicle dynamics and neurotransmitter release.

In summary, further research on ROGDI will enhance understanding of its interactions, implications in diseases, and roles in aging, potentially opening avenues for therapeutic interventions targeting its pathways.