### Overview of DECR1 Gene

**Gene Symbol:** DECR1  
**Official Name:** 2,4-dienoyl-CoA reductase 1  
**Location:** Cytosol, mitochondrion, nucleoplasm  
**Function:** DECR1 is an enzyme that plays a crucial role in the metabolism of unsaturated fatty acids, specifically through the beta-oxidation pathway. It catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to trans-3-enoyl-CoA, which is essential for the complete degradation of unsaturated fatty acyl-CoA derivatives.

### 1. Associated Genes

While specific gene association information was not provided in the summaries, DECR1 may interact with several genes involved in metabolic pathways, particularly those associated with fatty acid metabolism and mitochondrial functions. Some genes possibly linked include:

- **ACAD** gene family members (involved in acyl-CoA dehydrogenation).
- **ACOX** genes (involved in the peroxisomal beta-oxidation of fatty acids).

### 2. Aging and Age-Related Diseases

While direct links between DECR1 and aging or age-related diseases have not been extensively studied, its role in fatty acid metabolism suggests potential implications:

- **Metabolic disorders:** Given that fatty acid oxidation is crucial for energy production, any dysfunction in DECR1 may lead to metabolic issues.
- **Sarcopenia:** Age-related muscle loss could relate to fatty acid metabolism disturbances, as proper fatty acid oxidation is vital for muscle health.
- **Neurodegenerative Diseases:** Dysregulation of lipid metabolism has been implicated in diseases like Alzheimer's and Parkinson's, where aging plays a significant role.

### 3. Drug Interaction

There are no widely documented specific drugs or drug classes directly known to interact with DECR1. However, drugs that affect metabolic pathways or mitochondrial functions could potentially have indirect effects on the activity of DECR1. Some classes to consider might include:

- **Fatty acid synthesis inhibitors**, which may indirectly affect the enzyme's activity by altering the availability of its substrates.
- **NADPH-generating compounds**, as DECR1 uses NADPH as a cofactor, could potentially enhance its activity or influence its metabolic role.

### 4. Pathways and Biological Processes

DECR1 is involved in several key pathways and biological processes, including:

- **Fatty Acid Beta-Oxidation Pathway:** Integral to the breakdown of fatty acids to generate energy.
- **Metabolism of Unsaturated Fatty Acids:** Specifically processes 2,4-dienoyl-CoA derivatives for energy use.
- **Lipid Metabolism:** Involved indirectly in the broader scope of lipid homeostasis and metabolism.
- **Mitochondrial Function:** Works within the mitochondria, highlighting its role in cellular respiration and energy production.

In summary, DECR1 is a vital component in fatty acid metabolism, particularly in the context of unsaturated fatty acids, with potential implications for aging and metabolic health. Further research may elucidate more direct connections to specific diseases and therapeutic targets.