### FRMD8 Gene Overview

**Gene Symbol:** FRMD8  
**Location:** Human chromosome 1q21.3

#### Function:
The FRMD8 gene encodes a protein involved in the positive regulation of tumor necrosis factor (TNF) production and various related mechanisms. It plays a crucial role in promoting the stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 at the cell surface, thus preventing their degradation via the endolysosomal pathway. This involvement is significant for the ADAM17-mediated shedding of important ligands such as TNF, amphiregulin (AREG), HBEGF, and TGFA from the cell surface. Moreover, FRMD8 negatively regulates Wnt signaling, potentially by inhibiting the recruitment of AXIN1 to LRP6.

### 1. Associated Genes:
Although specific genes directly associated with FRMD8 are not comprehensively detailed in the summaries you provided, its interactions with the following pathways imply associations with related genes:

- **ADAM17:** An important gene involved in the shedding of various substrates including TNF.
- **iRHOM1/iRHOM2:** Regulation of these genes is influenced by FRMD8 for their role in protein stability and shedding processes.
- **LRP6 & AXIN1:** Genes involved in the Wnt signaling pathway which are negatively regulated by FRMD8.

### 2. Aging and Age-Related Diseases:
While direct research linking FRMD8 to aging or specific age-related diseases might be limited, the regulation of TNF production is relevant since elevated levels of TNF have been implicated in various chronic inflammatory conditions and age-related diseases such as Alzheimer’s disease, rheumatoid arthritis, and cardiovascular diseases. Further studies may elucidate FRMD8’s potential role in these contexts.

### 3. Drug Interactions:
Current drug interaction data for FRMD8 is limited. However, since the gene is involved in TNF production, it can be indirectly associated with drugs targeting TNF such as:

- **TNF Inhibitors:** Including monoclonal antibodies like infliximab (Remicade), adalimumab (Humira), and etanercept (Enbrel).
  
These drugs are often used in the treatment of autoimmune diseases that may have a TNF component.

### 4. Pathways and Biological Processes:
FRMD8 is involved in several biological processes and signaling pathways which include:

- **Regulation of Cytokine Production:** Involvement in the positive regulation of TNF, impacting immune responses and inflammation.
- **Endosomal Sorting Pathway:** By promoting iRhom stability, it affects the endolysosomal pathway for protein degradation.
- **Wnt Signaling Pathway:** Acts in a regulatory capacity, particularly by negatively influencing Wnt signaling and interacting with components like AXIN1 and LRP6.

These pathways highlight the gene's importance in cellular signaling and immune modulation, which are critical for maintaining homeostasis and responding to cellular stress and inflammation. Further functional studies are warranted to fully elucidate the biological roles and therapeutic implications of FRMD8.