### PPP2R2C Gene Overview

**Gene Symbol**: PPP2R2C  
**Location**: Human Chromosome 4 (4p14)  
**Gene Product**: Protein Phosphatase 2 Regulatory Subunit B, Gamma Isoform  

### 1. Associated Genes
The PPP2R2C gene interacts with multiple other genes, influencing various cellular pathways. While gene summaries may not cover all associations, some noteworthy genes associated with PPP2R2C include:  
- **PPP2CA**: Catalytic subunit of protein phosphatase 2 
- **PPP2CB**: Another catalytic subunit of protein phosphatase 2 
- **PPP2R1A** and **PPP2R1B**: Regulatory subunits that may interact with PPP2R2C
- **PTEN**: A tumor suppressor which functions in cell cycle regulation and may be impacted by protein phosphatase activity.
- **MTOR**: Involved in growth factor signaling, where PPP2R2C may act as a regulatory modulator.

### 2. Aging and Age-Related Diseases
Research indicates that the PPP2R2C gene may have implications in aging and age-related diseases, particularly in the context of:
- **Neurodegenerative Conditions**: Alterations in protein phosphatase activity have been linked to diseases such as Alzheimer's disease, where dysregulation of cellular signaling contributes to neurodegeneration.
- **Cancer**: Given that PPP2R2C plays a role in cell division and growth regulation, its dysfunction may contribute to tumorigenesis and the progression of age-associated malignancies.
- **Cardiovascular Diseases**: PPP2R2C is involved in pathways that influence cardiac cell growth and survival, suggesting potential links to cardiac aging and heart disease.

### 3. Drug Interactions
While specific drugs may not be exclusively developed for PPP2R2C, several classes of drugs can influence the pathways involving this gene:
- **Serine/Threonine Phosphatase Inhibitors**: Drugs targeting protein phosphatases in general (e.g., okadaic acid) may indirectly affect PPP2R2C activity.
- **Anticancer Agents**: Some drugs designed to target signaling pathways might interact with the regulatory mechanisms involving PPP2R2C, particularly in cancer therapies that target the phosphatase pathways.
- **Neuroprotective Agents**: Certain compounds aimed at modulating phosphorylation states in the nervous system may also influence the activity of phosphatase 2 complexes including those involving PPP2R2C.

### 4. Pathways and Biological Processes
PPP2R2C is involved in various biological processes and signaling pathways, such as:
- **Cell Cycle Regulation**: Plays a crucial role in promoting appropriate cell division and is involved in the transition phases of the cell cycle.
- **Signal Transduction**: Participates in multiple signaling pathways, including MAPK and AKT signaling, where the protein phosphatase activity is critical for substrate dephosphorylation.
- **Gene Expression Regulation**: Modulates transcriptional processes by dephosphorylating transcription factors or other proteins associated with chromatin remodeling.
- **Apoptosis**: Involved in apoptotic pathways, where it contributes to the regulation of cell survival and response to stress signals.

### Conclusion
PPP2R2C is a critical component of the protein phosphatase 2 complex, functioning as a regulatory subunit that influences cellular dynamics significantly. Its associations with various genes and pathways position it as a potential marker for understanding cellular control mechanisms in the context of aging and disease processes. Further research is warranted to elucidate its full range of interactions and implications in health and disease.