### EPHA10 Gene Overview

**Gene Symbol**: EPHA10  
**Location**: Chromosome 8q21.11

The EPHA10 gene encodes a member of the Eph family of receptor tyrosine kinases. These receptors primarily interact with ephrin ligands, specifically the ephrin-A family members, such as EFNA3, EFNA4, and EFNA5, to mediate a variety of cellular processes including cell adhesion, migration, and differentiation, particularly during the development of the nervous and vascular systems.

### 1. Associated Genes
EPHA10 is part of the Eph receptor signaling pathway and is associated with several other Eph receptors and ephrin ligands. While the summaries provided mention EFNA3, EFNA4, and EFNA5, the following genes are also relevant in this context:

- **EPHA1**: Another Eph receptor that interacts with ephrin ligands.
- **EFNA1, EFNA2, EFNA5**: Other ephrin ligands that might show cross-talk with EPHA10.
- **EPHB2**: Although it primarily interacts with ephrin-B ligands, it is part of the larger Eph/ephrin signaling network that complements the functions of EPHA10.

### 2. Aging and Age-Related Diseases
Research into the specific role of EPHA10 in aging or age-related diseases is limited. However, Eph receptors, including EPHA10, have been implicated in various processes that could impact aging and age-related conditions:

- **Neurodegeneration**: Altered Eph/ephrin signaling is observed in neurodegenerative diseases such as Alzheimer's. Disruption of neural connections can affect cognitive processes, which tend to decline with age.
- **Cancer**: The EPHA10 gene has also been studied for its role in tumorigenesis and metastasis. Age is a known risk factor for several cancers, which could lay the foundation for future research into EPHA10's role in age-related cancer susceptibility.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes widely recognized to directly target EPHA10. However, given its role in signaling pathways known to be involved in cancer and neurodegenerative diseases, research on small molecules and inhibitors of Eph receptors in general may have potential implications for therapies. Anti-cancer agents that affect receptor tyrosine kinases might indirectly influence EPHA10 signaling.

### 4. Pathways and Biological Processes
EPHA10 is involved in several crucial biological processes and signaling pathways:

- **Ephrin receptor signaling pathway**: This includes both forward signaling (from receptor to cell) and reverse signaling (from ephrin to cell).
- **Neurogenesis and Neural Patterning**: EPHA10 plays a role in the development and maintenance of neural networks.
- **Cell Migration and Adhesion**: These properties are essential in various physiological processes including tissue remodeling and repair.
- **Angiogenesis**: Eph/ephrin signaling may influence blood vessel formation, which is vital in many physiological and pathological processes, including wound healing and tumor growth.

### Conclusion
The EPHA10 gene is an important component of the Eph receptor family with implications in cell signaling, development, and potentially in aging and age-related diseases. While direct associations with therapeutic drugs are limited, its biological functions indicate potential routes for future research and therapeutic strategies in cancer and neurodegenerative diseases. Further investigations are necessary to fully elucidate the role of EPHA10 in these contexts.