### NAA11 Gene Overview

**Gene Symbol:** NAA11  
**Enzymatic Activity:** Peptide alpha-N-acetyltransferase activity  
**Function:** Involved in N-terminal acetylation of proteins, which is a crucial modification for protein stability and function.  
**Cellular Localization:** Golgi apparatus, centrosome, and nucleoplasm.  
**Complex Association:** Part of the NatA complex, which is involved in the acetylation of the N-termini of newly synthesized proteins.

### 1. Associated Genes

While the summaries provided above do not specify other genes directly associated with NAA11, some genes related to the N-terminal acetylation process include:

- **NAA10 (N-alpha-acetyltransferase 10)**: A well-known member of the N-acetyltransferase family that works in conjunction with NAA11 as part of the NatA complex.
- **NAA12**: Another member of the N-terminal acetyltransferase family that may interact or function parallel to NAA11.
- **NAA15**: A gene encoding a regulatory subunit of the NatA complex that may influence its stability and activity.

### 2. Aging and Age-Related Diseases

NAA11 has not been extensively studied in the context of aging directly; however, N-terminal acetylation is known to affect protein degradation pathways and cellular stress responses. These modifications can influence cellular aging processes:

- **Role in Proteostasis:** Proper N-terminal acetylation is essential for maintaining protein quality control in cells. Misfolded or improperly modified proteins can contribute to age-related diseases such as neurodegeneration (e.g., Alzheimer’s, Parkinson’s diseases).
- **Association with Cancer:** Abnormalities in acetylation processes have been linked to various cancers, suggesting a potential role of NAA11 in tumorigenesis, which may vary with age.

### 3. Drug Interactions

As of now, no specific drugs or drug classes are explicitly reported to directly target or interact with the NAA11 gene. However, since NAA11 is part of the NatA complex involved in protein acetylation, general investigations into acetylation-modulating drugs (e.g., histone deacetylase inhibitors) might have downstream implications for NAA11 functionality. Some compounds that influence acetylation states include:

- **Sirtuin Inhibitors:** Compounds that inhibit SIRT family proteins may have an indirect effect on the acetylation landscape.
- **Histone Deacetylase Inhibitors (HDACi):** Drugs like vorinostat or romidepsin that influence acetylation could potentially impact N-terminal acetyltransferase activity indirectly.

### 4. Pathways and Biological Processes

NAA11 is involved in several critical biological processes and pathways:

- **N-terminal Protein Acetylation:** As part of the NatA complex, it is critical for the co-translational modification of proteins.
- **Protein Modification:** Interventions in protein maturation, quality control, and degradation.
- **Cell Cycle Regulation:** Given its role at centrosomes, it may participate in processes related to cell division and integrity.
- **Signal Transduction:** N-terminal acetylation can affect various signaling pathways and transcriptional regulation by modulating protein interactions.

### Conclusion

The NAA11 gene plays a significant role in the regulation of protein modification through acetylation, contributing to various cellular functions and potentially influencing aging and age-related diseases. Further research could illuminate specific interactions with drugs and other genes, enhancing our understanding of its role in health and disease.
