The WEE1 gene is an important regulator of the cell cycle, moderating the transition from the G2 phase to mitosis. Below are additional details relevant to your inquiries:

### 1. Associated Genes
- **CDC2 (CDK1)**: As noted, WEE1 phosphorylates CDC2/cyclin B1 complex, regulating its activity.
- **Cyclin B1 (CCNB1)**: Interacts with CDK1, forming a crucial complex for G2 to M transition.
- **CHK1**: May work in a pathway that safeguards the cell cycle, as both CHK1 and WEE1 are involved in responding to DNA damage.
- **TP53**: The tumor suppressor protein p53 is known to have interactions with WEE1, particularly in stress responses and regulating the cell cycle.
- **PLK1** (Polo-like kinase 1): Plays a role in mitotic entry and could interact with WEE1 in promoting cell cycle progression.

### 2. Aging and Age-Related Diseases
- WEE1 has been implicated in cellular responses to DNA damage, a crucial factor in aging as genomic integrity often declines over time. 
- Alterations in WEE1 activity could contribute to age-related diseases such as cancer, where robust cell cycle control is crucial.
- High levels of WEE1 are associated with certain cancers and may impact cellular senescence; its modulation might thus play a role in therapies targeting age-related pathologies.

### 3. Drug Interactions
- **WEE1 Inhibitors**: Such as **AZD1775** (also known as MK-1775), which is a selective WEE1 inhibitor currently being investigated in clinical trials for various cancers, where it can sensitize tumor cells to DNA-damaging agents.
- **Chemotherapeutic Agents**: Drugs like **Gemcitabine** and **Cisplatin** may interact with WEE1, as WEE1 inhibition can lead to increased sensitivity of cancer cells to these agents.

### 4. Pathways and Biological Processes
- **Cell Cycle Regulation**: Specifically involved in the G2/M checkpoint.
- **DNA Damage Response Pathway**: Plays a role in the cellular response to DNA damage by modulating cyclin-dependent kinase activity.
- **Cellular Response to Stress**: WEE1 is involved in mechanisms that manage cellular stress during DNA replication and mitosis.
- **Mitotic Catastrophe**: Acts to prevent premature mitosis under conditions of DNA damage, preventing genomic instability.

By regulating critical checkpoints within the cell cycle, WEE1 plays a pivotal role in maintaining genomic integrity and response to cellular stress, which are fundamental processes that have broader implications in aging and cancer biology.