### WDR83 Gene Summary

**Gene Symbol:** WDR83  
**chromosomal location:** Chromosome 2 (2q34)

#### Basic Function
The WDR83 gene encodes a protein that is part of the WD-40 repeat protein family, characterized by motifs that facilitate protein-protein interactions. The WDR83 protein functions mainly as a molecular scaffold, allowing the assembly of various protein complexes, particularly those involved in cellular signaling pathways such as the extracellular signal-regulated kinase (ERK) pathway.

#### Key Functions
- **ERK Pathway Modulation:** WDR83 enhances ERK activation at low concentrations but inhibits it at high concentrations, highlighting its dual role depending on the cellular context.
- **Hypoxia Response:** WDR83 interacts with EGLN3, regulating hypoxia-inducible factor 1 (HIF-1α) and may promote its degradation, thus acting as a negative regulator of HIF1A.
- **Pre-mRNA Splicing:** The protein is also implicated as a component of the spliceosome, involved in the regulation of gene expression through RNA processing.

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### 1. Associated Genes
While the summaries mention EGLN3 as a key interacting partner, WDR83 may also be associated with other genes/entities in the ERK signaling pathway and cellular stress response mechanisms, including but not limited to:

- **MAPK1 (ERK2)**: A crucial component of the ERK signaling pathway.
- **HIF1A**: The protein product of this gene interacts with WDR83, particularly in the context of hypoxic response.
- Potential interactors include various cytokine receptors and growth factors that trigger ERK responses.

### 2. Aging and Age-Related Diseases
Although specific aging-related studies involving WDR83 may be limited, its roles in signaling pathways relevant to cell growth and response to stress (including hypoxia) suggest potential implications in:

- **Cancer:** Deregulation of ERK signaling is often implicated in tumorigenesis.
- **Neurodegenerative Diseases:** Modulation of hypoxia responses may affect neuroprotection and degeneration processes, which are key factors in aging.
- **Cardiovascular Diseases:** Given the role of ERK signaling in heart response to stress, WDR83 could influence cardiac health in an aging context.

### 3. Drug/Drug Classes Interaction
As of my last update, direct interactions of specific drugs with WDR83 have not been extensively characterized. However, some relevant interactions could include:

- **Targeted therapies for cancer:** Given its role in ERK signaling, WDR83 might interact indirectly with inhibitors of the MAPK/ERK pathway (e.g., MEK inhibitors).
- **HIF-1α inhibitors:** Since WDR83 negatively regulates HIF-1α, certain compounds aimed at HIF-1 modulation may indirectly affect WDR83 functions.
  
Further pharmacogenetic investigations may reveal more specific interactions.

### 4. Pathways and Biological Processes
WDR83 is involved in a variety of biological processes, including:

- **ERK Signaling Pathway:** Modulates cellular responses to growth factors and stressors to regulate proliferation and differentiation.
- **Response to Hypoxia:** Regulation of HIF-1α impacts cellular adaptations to low oxygen levels.
- **Pre-mRNA Splicing:** Involved in the assembly of spliceosome complexes that facilitate RNA processing.
- **Developmental Processes:** Implicated in various signaling pathways essential for organismal development.

Overall, WDR83 serves as a critical player in multiple cellular signaling processes, highlighting its importance in diverse biological functions and potential implications in health and disease, particularly concerning cancer and responses to hypoxic conditions. Further research may elucidate its exact roles and therapeutic potential in related diseases.