**PHKG1P3 Gene Overview**

- **Gene Symbol**: PHKG1P3
- **Description**: PHKG1P3 (Protein Kinase, AMP-activated, Gamma 1, Pseudogene 3) is classified as a pseudogene related to the PHKG1 gene, which encodes the catalytic subunit of the AMP-activated protein kinase (AMPK) gamma-1 (PHKG1). Pseudogenes are typically non-functional segments of DNA that resemble known genes but generally do not produce functional gene products.

### 1. Associated Genes
PHKG1P3 is closely related to its functional counterpart, **PHKG1**. Other potential gene relationships based on proximity of genomic location or shared biological pathways may include:
- **PRKAG1** (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1)
- **PRKAA1** (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
- **PRKAB1** (Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1)

### 2. Aging and Age-related Diseases
While specific studies directly linking PHKG1P3 to aging or age-related diseases are limited due to its pseudogene status, AMPK signaling pathways, which involve PHKG1, are known for their roles in cellular energy homeostasis, metabolism, and aging. Dysregulation of AMPK signaling has been implicated in age-related metabolic disorders such as:
- Type 2 Diabetes
- Obesity
- Cardiovascular diseases

Research into the function of AMPK often touches upon its regulatory roles in longevity and senescence, suggesting that while PHKG1P3 itself might not have direct associations, its functional counterpart's pathways are certainly implicated in these processes.

### 3. Drug Interactions
As PHKG1P3 is a pseudogene, it does not directly interact with drugs, nor does it yield active protein targets for pharmacological intervention. However, it is important to note that the associated genes from which it derives, particularly PHKG1, are subjects of study in drug development targeting AMPK-related pathways. 

Key drug classes that target the AMPK pathway include:
- **AMPK Activators** (e.g., Metformin)
- **Inhibitors of Cellular Energy Consumption** (potentially influencing AMPK activity in metabolic contexts)

### 4. Pathways and Biological Processes
PHKG1P3 does not play an active role in biological pathways due to its status as a pseudogene. However, pathways involving its related functional gene (PHKG1) include:
- The **AMPK signaling pathway** which regulates energy balance and metabolism.
- The **Regulation of lipid metabolism** specifically through energy homeostasis mechanisms.
- Potential involvement in pathways linked to metabolic responses to stress due to its association with AMPK.

In summary, while PHKG1P3 itself may not exhibit functional activity, it serves as a pseudogene associated with more substantial functions through related genes. Its indirect associations with metabolic regulation and possible implications in aging and disease merit further investigation into its potential roles in health and disease contexts.