### SLC27A2 Gene Overview

**Gene Symbol:** SLC27A2  
**Location:** Human chromosome 14  

The SLC27A2 gene encodes a protein that functions as an isozyme of the long-chain fatty-acid-coenzyme A ligase family. This protein is primarily involved in the conversion of long-chain fatty acids into fatty acyl-CoA derivatives, which are essential for various metabolic processes, including lipid biosynthesis and fatty acid degradation. 

#### 1. Associated Genes
While the summaries you provided mention key features of SLC27A2, it is also known to be associated with several other genes, although specific details on these may not always be provided in standard summaries. Common associated genes may include:
- **ABCD1:** Related to the transport of fatty acids to peroxisomes.
- **ACOX1:** Involved in fatty acid oxidation pathways.
- **SLC27A1:** Another gene in the SLC27 family that also mediates long-chain fatty acid transport.

#### 2. Aging and Age-Related Diseases
Research has indicated that alterations in SLC27A2 function could be linked to metabolic disorders and age-related diseases, particularly those involving lipid metabolism. Decreased activity of this gene has been implicated in:
- **X-linked adrenoleukodystrophy (X-ALD):** A genetic disorder that affects the nervous system and adrenal glands due to the accumulation of very-long-chain fatty acids.
- Dyslipidemia and associated conditions like cardiovascular diseases, which can be more prominent with aging due to changes in lipid metabolism efficiency.

Additionally, the role of SLC27A2 in regulating fatty acid uptake in tissues undergoing high levels of β-oxidation suggests it may play a significant role in aging-related metabolic adaptations.

#### 3. Drug Interactions
While specific pharmaceuticals targeting SLC27A2 directly may not be extensively documented, it is known that certain classes of drugs that modulate lipid metabolism can indirectly influence the expression or activity of SLC27A2. These may include:
- **Fibrates:** Drugs that can lower triglyceride levels and are known to affect fatty acid metabolism.
- **Statins:** Although primarily cholesterol-lowering agents, they can also impact pathways involving fatty acids.

Research is ongoing to explore specific inhibitors or enhancers of SLC27A2 and its isoforms.

#### 4. Pathways and Biological Processes
SLC27A2 is involved in multiple important biological pathways and processes including:
- **Lipid Metabolism:** Specifically the activation and transport of long-chain and very-long-chain fatty acids.
- **Beta-Oxidation:** The breakdown of fatty acids for energy production.
- **Sphingolipid Metabolism:** Potentially contributing to the synthesis of sphingosine-1-phosphate.
- **Peroxisome Function:** Plays a role in peroxisomal lipid metabolism, which is critical in preventing the accumulation of very-long-chain fatty acids.

In summary, SLC27A2 plays a fundamental role in lipid processing and metabolism, affecting a variety of biological processes, interactions with other metabolic enzymes, and linking to aging and related diseases. Ongoing research continues to elucidate its roles and potential as a target for therapeutic interventions.