### NUP153 Gene Overview

**Gene Symbol:** NUP153  
**Location:** Chromosome 11 (11q13.4)  
**Function:** The NUP153 gene encodes a protein component of the nuclear pore complex (NPC), which mediates the transport of macromolecules between the nucleus and cytoplasm. NUP153 plays a role in nucleocytoplasmic transport and is involved in the quality control and retention of unspliced mRNAs in the nucleus.

### 1. Associated Genes
NUP153 is known to interact with several other genes and proteins, primarily within the context of nucleocytoplasmic transport and regulation of mRNA. Some associated genes include:

- **Nuclear Transport Receptor Genes** (e.g., **NXF1**, involved in mRNA export).
- **TPR (Translocated Promoter Region)**, which is implicated in mRNA transport regulation.
- **KHDRBS1**, which may be involved in mediating mRNA export.
- **PRKCI (Protein Kinase C iota)**, linked to various cellular signaling pathways that may modulate nuclear transport processes.

### 2. Aging and Age-related Diseases
NUP153 has been implicated in various aspects of aging:

- **Cellular Senescence:** The functionality of nuclear pore complexes tends to deteriorate with age, leading to disruptions in nucleocytoplasmic transport. This decline may be associated with increased cellular senescence and aging-related diseases.
- **Neurological Disorders:** Misregulation of nucleoporins, including NUP153, has been connected with neurodegenerative diseases, such as Alzheimer's disease, where aberrant mRNA transport can contribute to pathogenic mechanisms.
- **Cancer:** NUP153 expression levels may be altered in certain tumors, indicating potential involvement in tumorigenesis and cancer progression, which can be linked with age-related susceptibility to malignancies.

### 3. Drug Interaction and Drug Classes
While specific drugs targeting NUP153 are not widely documented, the role of NUP153 in nucleocytoplasmic transport could imply potential interactions with:

- **Importin and Exportin Inhibitors:** These drugs may have effects on the transport mechanisms that involve NUP153 and could influence RNA metabolism.
- **Antiviral Agents:** Some antiviral therapies target pathways involving nucleocytoplasmic transport, which could indirectly affect NUP153’s function.

### 4. Pathways and Biological Processes
NUP153 is involved in several key biological processes:

- **Nucleocytoplasmic Transport:** Central to its role in transporting proteins and RNA across the nuclear envelope.
- **Response to DNA Damage:** Participates in the cellular response to DNA damage by regulating the transport of repair proteins and the stability of RNA.
- **Gene Expression Regulation:** Implicated in the regulation of gene expression by modulating mRNA export and other related processes.
- **RNA Metabolism:** Plays a significant role in the maturation, export, and retention of mRNAs within the nucleus.

### Summary
NUP153 is a critical nucleoporins' member, contributing significantly to nucleocytoplasmic transport and mRNA regulation. While its direct pharmacological targeting may not be well-established, its critical cellular roles and associations with various pathways indicate that it could serve as a potential focus for further research and therapeutic intervention, particularly concerning age-related diseases and interventions.