### SEMA5A-AS1 Gene Overview

**Gene Symbol:** SEMA5A-AS1  
**Full Name:** Sema Domain Containing 5A Antisense RNA 1

SEMA5A-AS1 is a long non-coding RNA (lncRNA) associated with the SEMA5A gene, which encodes a protein involved in neurological processes and cellular signaling. Antisense RNAs like SEMA5A-AS1 often play regulatory roles in gene expression.

### 1. Associated Genes
SEMA5A-AS1 is primarily associated with the **SEMA5A** gene. However, lncRNAs can affect a variety of additional genes, and interventions or their expression might relate strongly to several other genes indirectly. In particular, it is important to consider pathways that include receptors and signaling molecules in neurodevelopment, where SEMA5A's protein product functions. This might imply interactions with genes involved in:

- **NEGR1** (neurite growth factor)
- **NTRK1** (Neurotrophic receptor tyrosine kinase 1)
- **RHOA** (Ras homolog family member A)
  
While direct associations with other genes might not be explicitly documented, their functions are likely interconnected in certain biological contexts.

### 2. Aging and Age-Related Diseases
Research indicates that lncRNAs, including SEMA5A-AS1, can play roles in cellular stress responses and may be involved in neurodegenerative diseases, a hallmark of aging. Specific details regarding SEMA5A-AS1 and its involvement with aging are still emerging; however, there’s evidence that SEMA5A may be relevant in conditions like:

- **Alzheimer's Disease:** Impaired signaling pathways related to SEMA5A could contribute to synaptic dysfunction.
- **Schizophrenia:** Genetic variations in SEMA5A have been implicated in neurodevelopmental disorders.

Further investigations into lncRNAs suggest that dysregulation of these molecules might correlate with several age-related pathologies, emphasizing the need for ongoing research.

### 3. Drug Interactions
As of the latest information, there are no specific drugs or drug classes documented to have direct interactions with SEMA5A-AS1. Nevertheless, considering its role in developmental and regulatory processes, it may influence cellular responses to therapeutics utilized in neurodegenerative or psychiatric conditions, either indirectly or as a biomarker.

### 4. Pathways and Biological Processes
SEMA5A-AS1, being an antisense RNA, is linked to regulatory functions rather than direct enzymatic activities. However, several biological processes and pathways can be associated with its parent gene, SEMA5A:

- **Semaphorin Signaling Pathway:** Involved in axon guidance and neuronal development.
- **Neurogenesis:** Implicated in the formation of new neurons from neural stem cells during development and may play a role in adult neurogenesis as well.
- **Signal Transduction:** Affects pathways related to neural differentiation, possibly influencing underlying mechanisms in diseases of the nervous system.

Additionally, research into lncRNAs indicates they may alter chromatin structure or interact with proteins and mRNAs, impacting multiple processes such as stress responses and gene silencing.

### Conclusion
SEMA5A-AS1, while an antisense RNA, plays a potentially critical role in regulating SEMA5A and related pathways, particularly in the nervous system and possibly aging. More work is needed to elucidate its full impact on health and disease, highlighting its potential as a significant player in neurobiology and age-related disorders.