### SULT1C2 Gene Overview

**Gene Symbol:** SULT1C2  
**Location:** Human chromosome 4q12  
**Function:** The SULT1C2 gene encodes a member of the sulfotransferase family of enzymes, which catalyze the sulfate conjugation of a variety of substrates, including hormones, neurotransmitters, drugs, and xenobiotics. Specifically, SULT1C2 utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as a sulfonate donor to transfer sulfate groups to phenolic compounds, with a notable activity for p-nitrophenol and N-Hydroxy-2-acetylaminofluorene. However, it does not sulfonate steroids, dopamine, acetaminophen, or α-naphthol.

### 1. Associated Genes
Although SULT1C2 may not have extensive associations noted in summary sources outside its function, it is part of the SULT (sulfotransferase) gene family. Other genes in this family include:
- **SULT1A1**: Involved in the sulfonation of a wide range of xenobiotics and endogenous compounds.
- **SULT1B1**: Primarily involved in the metabolism of neurotransmitters.
- **SULT2A1**: Sulfates steroid hormones, which could provide insights into interactions with SULT1C2.

### 2. Aging and Age-related Diseases
Currently, there is limited specific literature linking SULT1C2 directly to aging or age-related diseases. However, since sulfotransferases are involved in drug metabolism and detoxification pathways, variations in their activity due to age may modulate the metabolism of drugs and xenobiotics, potentially affecting the pharmacokinetics and pharmacodynamics in older populations.

Additionally, since SULT1C2 can catalyze the formation of potentially mutagenic metabolites from carcinogens, alterations in its expression and function could contribute to age-related increases in cancer susceptibility.

### 3. Drug Interactions
Although specific drugs interacting with SULT1C2 are not extensively characterized, the following points are noteworthy:
- **Drugs of Interest:** The enzyme does not sulfonate common drugs such as acetaminophen or dopamine, but its activity towards compounds like p-nitrophenol indicates involvement in the metabolism of certain chemical entities.
- **Drug Classes:** Since SULT1C2 can metabolize xenobiotics, it may be involved in the metabolic clearance of various environmental toxins or drug-like compounds, resulting in individual variability in drug response and toxicity.

### 4. Pathways and Biological Processes
SULT1C2 is involved in several biological processes and pathways:
- **Phenylalanine Metabolism Pathway:** Involvement in the sulfation of phenolic compounds, which is essential in biotransformation.
- **Metabolism of both endogenous and exogenous substances:** The enzyme plays a role in detoxification pathways by sulfonating various phenolic compounds.
- **Xenobiotic Metabolism:** A broader theme within drug metabolism where sulfotransferases contribute to the biotransformation and elimination of drugs and environmental chemicals.

### Summary
SULT1C2 is a key member of the sulfotransferase family with specific functionalities that highlight its role in toxicological and pharmacological contexts. However, further research is needed to elucidate its function in the context of aging and related health implications.