### PEBP4 Gene Overview

**Gene Symbol:** PEBP4  
**Protein Summary:** Phosphatidylethanolamine-binding protein 4 (PEBP4) is implicated in promoting AKT phosphorylation, indicating a potential role in the phosphoinositide 3-kinase (PI3K)-AKT signaling pathway.

### 1. Associated Genes
PEBP4 has been noted to interact with or be associated with several other genes, although specific gene associations not mentioned in your summaries require further literature mining. Genes often referenced in relation to PEBP4 include:
- **AKT1:** The serine/threonine kinase that PEBP4 helps phosphorylate.
- **BCL2:** Involved in apoptosis and may interact with the signaling pathways affected by PEBP4.
- **PIK3CA:** Part of the signaling pathway that PEBP4 engages in.
  
Please note that specific experimental validation is necessary to confirm the interaction with associated genes.

### 2. Aging and Age-related Diseases
Research indicates that pathways involving PEBP4 and AKT are important in cellular aging and may influence age-related diseases. Alterations in the PI3K-AKT pathway can affect:
- **Cellular Survival:** Dysregulation of apoptosis can lead to age-related degenerative diseases.
- **Cancer:** Given PEBP4’s role in promoting AKT phosphorylation, it may impact tumorigenesis and cancer progression, often more prevalent in older populations.

However, detailed data explicitly linking PEBP4 to aging or specific aging-related diseases remain limited and warrant further investigation.

### 3. Drug Interactions
While direct interactions with specific drugs or drug classes are not extensively characterized in public databases specifically for PEBP4, it may be involved indirectly through the pathways it influences. Drugs that modulate the PI3K-AKT signaling pathway might interact indirectly with functions associated with PEBP4. Classes that may have interactions include:
- **AKT Inhibitors:** These target downstream pathways that PEBP4 is part of.
- **Chemotherapeutics:** Certain cancer treatments might influence signaling pathways linked with PEBP4.

Specific drug interactions should be confirmed through targeted pharmacological studies.

### 4. Pathways and Biological Processes
PEBP4 is involved in several critical biological pathways:
- **PI3K-AKT Signaling Pathway:** The primary pathway where PEBP4 plays a critical role through AKT activation.
- **Apoptosis:** PEBP4 may influence survival pathways, affecting cell death processes.
- **Neuroprotection:** Some studies have suggested roles in neuroprotective pathways, which may be linked to its signaling interactions.

### Conclusion
The PEBP4 gene is an important player in the AKT signaling pathway, with implications in cancer and potentially aging-related diseases. As research progresses, further elucidation of its role and interactions may provide significant insights into targeted therapies and interventions in age-related pathologies.