### KLHL13 Gene Overview

**Gene Symbol:** KLHL13  
**Chromosomal Location:** Human chromosome 10 (10q26.3)

**Function:** 
The KLHL13 gene encodes a protein that is part of the BTB (Bric à Brac, Tramtrack, Broad Complex) and kelch domain-containing superfamily. The KLHL13 protein acts as a substrate-specific adaptor for the Cullin 3-based E3 ubiquitin-protein ligase complex, which is pivotal during mitosis for proper chromosome segregation and successful completion of cytokinesis. It specifically mediates the ubiquitination of Aurora B kinase (AURKB), a critical regulator of mitotic progression.

### 1. Associated Genes
KLHL13 is primarily associated with several key genes and proteins in the context of the ubiquitination pathway and cell cycle regulation, including:
- **AURKB (Aurora Kinase B)**: An important protein that KLHL13 helps regulate through ubiquitination.
- **CUL3 (Cullin 3)**: A core component of the E3 ubiquitin ligase complex that includes KLHL13.
- **RBX1 (RING-Box 1)**: Another essential component of the E3 ubiquitin ligase complex.
- Other potential interacting partners within the BCR (BTB-CUL3-RBX1) complex that may not be specifically mentioned but include various substrates targeted during cell cycle regulation.

### 2. Aging and Age-Related Diseases
While specific studies directly linking KLHL13 to aging or specific age-related diseases are limited, physiological alterations in the ubiquitin-proteasome pathway, of which KLHL13 is a crucial component, have been implicated in various age-related conditions. Deregulation of cell cycle processes, and improper cytokinesis may contribute to cellular senescence and tumorigenesis, suggesting a potential role in age-related pathologies such as:
- **Cancer**: Disruption in ubiquitin-mediated control of cell cycle can lead to tumorigenesis as cells escape the normal regulatory mechanisms.
- **Neurodegenerative Diseases**: Misregulation of cellular processes, including those mediated by KLHL13, might contribute to neuronal cell death and the progression of diseases like Alzheimer's or Parkinson's, which often exhibit defects in protein homeostasis.

### 3. Drug/Drug Classes Interactions
Currently, there are no specific drugs or drug classes directly associated with KLHL13 in terms of pharmacological interaction. However, since KLHL13 is part of ubiquitin-proteasome pathways, compounds that influence protein degradation or the cell cycle, such as:
- **Proteasome Inhibitors** (e.g., Bortezomib) might indirectly affect the functioning of KLHL13 due to its role in proteasomal degradation of specific substrates.
- **Aurora Kinase Inhibitors** (like Alisertib) could also exert implications on processes involving KLHL13 due to its involvement in regulating AURKB.

### 4. Pathways and Biological Processes
KLHL13 is involved in a number of critical biological processes, including:
- **Cell Cycle**: Essential for the proper timing of cell cycle progression and cytokinesis.
- **Chromosome Segregation**: Plays a significant role in ensuring accurate segregation of chromosomes during mitosis.
- **Ubiquitination**: Functions within the ubiquitin-proteasome system, mediating protein tagging for degradation.
- **Mitotic Spindle Organization**: Influences the architecture and dynamics of the spindle apparatus.
  
**Key Pathways**:
- **Ubiquitin-mediated proteolysis**: Active in the ubiquitin-proteasome pathway, helping to tag proteins for degradation.
- **Cell cycle regulation**: Involved in mitotic progression, ensuring that cells divide properly.

In conclusion, KLHL13 is a vital gene in regulating essential cellular processes, and its dysregulation can be implicated in various cellular malfunctions, particularly in cancer and potentially in neurodegenerative processes. Further research could elucidate more specific associations with aging and targeted drug interactions.