### TTC28 Gene Summary

**Gene Symbol**: TTC28  
**Function**: TTC28 encodes a protein that is implicated in the regulation of the mitotic cell cycle and is suggested to facilitate the binding of kinases. The protein primarily localizes to the midbody during cell division. Its role is thought to involve the condensation of spindle midzone microtubules, which is essential for the successful formation of the midbody, a structure critical for cytokinesis.

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### Additional Gene Associations
- **Associated Genes**: While specific genes directly associated with TTC28 are not always highlighted in summaries, it is known that genes involved in mitotic regulation and cytokinesis could be functionally related. Some possible associated genes include:
  - **KIF14**: Implicated in cleavage furrow formation.
  - **MKLP1 (KIF23)**: Involved in mitotic spindle formation and midbody assembly.
  - **BIRC5 (Survivin)**: Regulates cell division and is part of the chromosomal passenger complex.

### Aging and Age-Related Diseases
- **Aging**: The involvement of TTC28 in cell division suggests a possible link to aging processes, as cell division and mitotic integrity are crucial in maintaining tissue homeostasis.
- **Age-Related Diseases**: Disruptions in mitosis can contribute to age-related diseases, including cancer. While direct links of TTC28 to specific age-related diseases are less documented, its role in spindle dynamics may implicate it in tumorigenesis through improper cytokinesis leading to aneuploidy.

### Drug Interactions
- Currently, there is limited literature specifically detailing drugs or drug classes that interact with the TTC28 gene or its protein product. However, agents targeting kinases or those involved in the cell cycle may indirectly affect pathways involving TTC28. Classes of drugs that could be considered include:
  - **Kinase inhibitors**: These drugs could potentially impact the biological functions of TTC28, given its kinase binding activity.
  - **Anticancer agents**: Drugs that affect mitotic progression might have relevant interactions through pathways modulated by TTC28.

### Pathways and Biological Processes
- **Biological Processes**:
  - **Mitotic Cell Cycle Regulation**: TTC28 is fundamentally involved in processes governing the progression and accuracy of mitosis.
  - **Cytokinesis**: It plays a critical role in the final stages of cell division.
  
- **Pathways**:
  - **Cell Cycle Pathway**: Particularly, it regulates the stability and organization of microtubules during mitosis.
  - **Spindle Assembly Checkpoint**: As a regulatory element, it may participate in ensuring that proper chromosomal alignment occurs before division.

Given the above associations, further research may be necessary to fully elucidate the specific interactions and implications of the TTC28 gene in various biological contexts and diseases.