### SNORD26 Gene Overview

**Gene Symbol:** SNORD26

**Description:**  
SNORD26 (Small Nucleolar RNA Domain 26) is a non-coding RNA gene that is part of the C/D box class of small nucleolar RNAs (snoRNAs). These types of snoRNAs are primarily involved in guiding the modification of other RNAs, particularly ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs), through methylation and pseudouridylation processes. SNORD26 is located in the nucleolus, where it contributes to the biogenesis of ribosomes.

### 1. Gene Associations
While direct associations with specific genes may not be formally documented for SNORD26 in the NCBI or UniProt databases, snoRNAs, in general, have potential indirect associations with various key genes involved in ribosomal biogenesis and RNA processing. These interactions can affect several ribosomal proteins and regulatory proteins involved in these pathways. Researchers have studied various snoRNAs in the context of gene expression regulation, so some interactions could include:

- **Ribosomal protein genes (e.g., RPL family)**
- **Other snoRNA genes (e.g., SNORD family members)**
  
### 2. Aging and Age-Related Diseases
Information specifically linking SNORD26 to aging or age-related diseases is sparse. However, alterations in snoRNA expression profiles have been associated with various cancers and age-related conditions. Since SNORD26 is involved in ribosomal RNA modification, any dysregulation in its expression could theoretically affect cellular senescence and contribute to age-related decline.

- **Potential Associations:**
  - Abnormal expression of snoRNAs has been linked to various cancers, which are often age-related.
  - Changes in ribosomal biogenesis and function are frequently observed in the context of aging and pluripotency.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes that are well-documented to interact directly with SNORD26. However, several drug classes that modulate cellular processes related to ribosome function or RNA processing may indirectly influence the activity of snoRNAs, including SNORD26:

- **Anticancer Drugs:** Since the ribosomal function is often altered in cancer cells, drugs targeting ribosome biogenesis might impact snoRNA expression.
- **RNA Polymerase Inhibitors:** Agents that inhibit transcription processes can also affect snoRNA levels.

### 4. Pathways and Biological Processes
SNORD26 is primarily involved in:

- **Ribosome Biogenesis:** SNORD26, like other snoRNAs, is fundamental in the chemical modification of rRNA, which is critical for the assembly and function of ribosomes.
- **RNA Processing:** SNORD26 may participate in various RNA processing activities, influencing the maturation and modification of different RNA molecules, particularly in the nucleolus.
- **Cellular Growth and Proliferation:** By modulating ribosomal RNA and protein synthesis, snoRNAs contribute to the regulation of cellular proliferation.

### Summary
While the SNORD26 gene primarily plays a role in guiding RNA modifications critical for ribosome biogenesis, further studies are needed to elucidate its specific functions in aging and disease processes as well as its interactions with pharmacological agents. Current evidence suggests a broader connection to the ribosomal machinery, which is fundamental to many cellular processes involved in both health and disease.