### VOPP1 Gene Overview

**Gene Symbol:** VOPP1  
**Location:** Cytoplasmic vesicle membrane and endosome  
**Function:** Integral component of organelle membranes. It is primarily involved in regulating the transcriptional activity of NFKB1, facilitating its nuclear translocation, DNA-binding, and its associated apoptotic responses upon overexpression. VOPP1 may also sequester WWOX in lysosomal vesicles, modulating its function as a tumor suppressor.

### 1. Associated Genes

While the summaries provided do not specify additional genes, VOPP1 is implicated in regulatory networks involving:

- **NFKB1 (Nuclear Factor Kappa B Subunit 1):** As stated, VOPP1 enhances the transcriptional activity of NFKB1.
- **WWOX (WW Domain Containing Oxidoreductase):** VOPP1 may sequester WWOX, influencing its role in pathways related to cancer.
- **PTEN (Phosphatase and Tensin Homolog):** While not directly mentioned, VOPP1's role in apoptosis and cell signaling suggests possible relevance.

These associations indicate a likely interplay in cancer biology, immune response, and apoptosis.

### 2. Aging and Age-Related Diseases

Research shows that dysregulation of VOPP1 may have implications in age-related diseases, particularly cancer, due to its role in apoptosis and tumor suppression. Given that:

- **Tumor Suppression:** VOPP1's effect on WWOX, a known tumor suppressor gene, might be significant in the context of aging, where genomic stability declines.
- **Neurodegenerative Diseases:** Some studies have suggested a potential involvement of VOPP1 in neuroprotective mechanisms, possibly influencing diseases such as Alzheimer’s, where inflammatory pathways play a role.

Though specific studies connecting VOPP1 directly to aging are still emerging, its involvement in apoptosis and tumor promotion indicates that it could have broader implications for aging and associated disorders.

### 3. Drug Interactions

Currently, specific drugs or drug classes directly targeting VOPP1 are not well-defined in public databases. However, given its role in apoptosis and cellular signaling pathways:

- **Anti-cancer Drugs:** As VOPP1 is involved in the regulation of NFKB1 and WWOX, drugs affecting these pathways (e.g., NF-κB inhibitors or chemotherapeutics) may indirectly affect VOPP1 function.

- **Targeted Therapies:** Investigational therapies that modulate apoptotic pathways or inflammation might be relevant for manipulating the effects of VOPP1.

Further research is required to elucidate any specific pharmacological agents known to target VOPP1 directly.

### 4. Pathways and Biological Processes

VOPP1 is involved in several crucial pathways and biological processes, including:

- **NF-kappa B Signaling Pathway:** As VOPP1 enhances NFKB1's activity, it plays a significant role in immune responses, apoptosis, and cell survival.
- **Apoptosis Regulation:** VOPP1's impact on apoptotic pathways underscores its importance in programmed cell death.
- **Tumor Suppressor Pathways:** The interaction with WWOX implicates VOPP1 in pathways related to tumor suppression.
- **Vesicular Trafficking and Secretion:** As an integral membrane protein, VOPP1 may influence membrane trafficking and endosomal sorting processes.

In summary, the VOPP1 gene is centrally involved in critical cellular processes such as apoptosis and signal transduction, with emerging relevance in cancer biology and potentially age-related diseases. Further exploration of its interactions, pathways, and therapeutic targets is warranted for a comprehensive understanding of its role.