### CCNDBP1 Gene Overview

**Gene Symbol:** CCNDBP1  
**Location:** Human gene located on chromosome 11 (11q21).

The CCNDBP1 gene encodes a protein that interacts with various key regulatory proteins involved in cell cycle and transcriptional control. It has been established that CCNDBP1 is involved in immunological signaling and cellular proliferation, notably functioning as a negative regulator of cell cycle progression primarily through its interaction with the cyclin D/CDK4 complex.

### Additional Relevant Information

1. **Associated Genes:**
   - **RB1 (Retinoblastoma 1):** CCNDBP1 interacts with proteins involved in regulating RB1 phosphorylation.
   - **E2F1 (E2F Transcription Factor 1):** Downstream effector in the cell cycle, with CCNDBP1 inhibiting E2F1-mediated transcription.
   - **Grap2 (Grb2-related adaptor protein 2):** Identified through interaction studies, playing a role in immune signaling pathways.
   - **Cyclin D1 (CCND1):** Regulation of cyclin D-dependent kinases is influenced directly by CCNDBP1.
   - Other potential interactions may involve transcription factors and proteins related to the transcriptional regulation of liver-specific genes.

2. **Aging and Age-Related Diseases:**
   - While specific aging-related studies on CCNDBP1 are limited, its role in regulating cell proliferation and the cell cycle suggests involvement in cellular senescence and tumorigenesis. Poor regulation could contribute to age-related disorders, including various cancers.
   - Its effects on liver-specific gene expression may also implicate CCNDBP1 in hepatic aging and age-related liver diseases such as non-alcoholic fatty liver disease (NAFLD) or hepatic fibrosis.

3. **Drug Interactions:**
   - Currently, direct drug interactions specifically targeting CCNDBP1 have not been extensively characterized. However, drugs that modulate cell cycle regulation, such as CDK inhibitors (e.g., Palbociclib), could potentially affect pathways that involve CCNDBP1.
   - Additionally, immunomodulatory drugs may indirectly influence CCNDBP1 activity through their effects on immune cell signaling.

4. **Pathways and Biological Processes:**
   - **Cell Cycle Regulation:** CCNDBP1 is a key player in negative regulation of cell cycle progression, particularly influencing the G1/S checkpoint.
   - **Transcriptional Regulation:** Inhibition of E2F-dependent transcription and liver-specific gene expression regulation.
   - **Immune Response:** Involved in pathways relevant to leukocyte activation and immune signaling, such as through its interaction with Grap2.
   - **Signal Transduction Pathways:** Exhibits involvement in various signaling pathways, particularly those that regulate cellular proliferation and differentiation.

### Conclusion

In summary, the CCNDBP1 gene plays an integral role in regulating cell cycle progression and transcriptional activity, with implications in immune signaling and potential associations with cellular aging and cancer. Further studies may elucidate its precise role in age-related conditions and therapeutic targets.