The HOXB-AS3 gene is a long non-coding RNA (lncRNA) that plays a critical role in regulating the alternative splicing of the PKM gene and the stability of MYC, which are both important in cellular metabolism and growth regulation. Here's a detailed response based on your requests:

### 1. Associated Genes
The HOXB-AS3 gene has interactions with several genes, particularly:

- **PKM**: The most directly impacted by HOXB-AS3 through its regulation of exon inclusion/exclusion.
- **HNRNPA1**: A splicing factor whose activity is inhibited by HOXB-AS3.
- **MYC**: HOXB-AS3 promotes MYC stability through the interaction with IGF2BP2, enhancing MYC activity.
- **IGF2BP2**: Involved in the regulation of MYC stability.

While the summaries you've provided focus on these relationships, other related genes may include those involved in the splicing machinery or metabolic pathways where PKM and MYC are key players.

### 2. Aging and Age-Related Diseases
Currently, direct evidence linking HOXB-AS3 to aging or specific age-related diseases is limited, but:

- **MYC Regulation**: The MYC gene is known to be involved in cellular proliferation and metabolism, and its dysregulation has been implicated in numerous age-related conditions, including cancer.
- **Metabolic Dysregulation**: Alterations in PKM isoforms have been associated with various metabolic diseases, which often exhibit higher incidence with age.
- **Long Non-Coding RNAs in Aging**: Research suggests that some lncRNAs play roles in cellular senescence and other age-related processes, though HOXB-AS3's specific involvement in these pathways remains to be clearly defined.

### 3. Drug Interactions
While specific drugs that directly target or interact with the HOXB-AS3 gene have not been well-documented, indirect interactions through the pathways influenced by the PKM and MYC genes may suggest:

- **Anticancer Drugs**: Given the role of MYC in tumor biology, drugs that target MYC or its pathways may indirectly affect HOXB-AS3 function.
- **Metabolic Modulators**: Compounds targeting metabolic pathways associated with PKM could also have consequences on the expressions and effects mediated by HOXB-AS3.

### 4. Pathways and Biological Processes
HOXB-AS3 is involved in several significant biological processes:

- **Nuclear RNA Processing**: Regulation of transcription and splicing of pre-mRNA.
- **Alternative Splicing**: Specifically promotes alternative splicing in PKM, favoring M1 isoform production.
- **Cancer Pathways**: Involvement in pathways modulated by MYC suggests relevance in oncogenesis.
- **Regulatory Pathways of Gene Expression**: Through modulation of post-transcriptional modifications and stability of mRNAs like MYC and others involved in cellular proliferation.

### Summary
HOXB-AS3 functions as a regulatory lncRNA that influences splicing factors and can alter the expression of key metabolic and oncogenic genes. While its specific role in aging and associated diseases is still being explored, it has significant implications in cancer biology and cellular metabolism. Further research is necessary to clearly define its role across various biological pathways and potential therapeutic targets.