### ZNF215 Gene Overview

**Gene Symbol:** ZNF215  
**Location:** Chromosome 11p15  
**Description:** The ZNF215 gene encodes a zinc finger protein that is part of a larger family of zinc finger transcription factors. The protein features distinct domains, including an SRE-ZBP and SCAN domain, a KRAB domain, and multiple zinc finger motifs, which are typically involved in DNA binding and transcriptional regulation. It is imprinted in a tissue-specific manner, with higher expression levels observed in the testis.

### 1. Associated Genes
While ZNF215 is primarily noted for its role in the context of Beckwith-Wiedemann syndrome and its surrounding genomic region, there are several other genes located in proximity to this region on 11p15. Some associated genes include:
- **KCNQ1**: Known for its role in long QT syndrome and cardiac arrhythmias.
- **CDKN1C**: Involved in cell cycle regulation; mutations can lead to growth disorders.
These genes can be affected by imprinting events in the same 11p15 region, leading to syndromic conditions when dysregulated.

### 2. Aging and Age-Related Diseases
While there is limited direct evidence specifically linking ZNF215 to aging or age-related diseases, the gene's involvement in transcriptomic regulation could hypothetically play a role in cellular aging processes, given that transcription factors are critical for maintaining healthy cellular function over time. Epigenetic changes associated with genetic imprints like ZNF215 may influence developmental and aging pathways. Further research may elucidate more specific associations.

### 3. Drug Interactions
Currently, there is no established specific drug or drug class directly reported to interact with ZNF215. However, as ZNF215 is a transcription factor, it may be subject to modulation by drugs that influence gene expression more broadly (e.g., histone deacetylase inhibitors or other epigenetic modulating agents). The pharmacological impact may not be straightforward and could vary based on the broader regulatory networks in which ZNF215 plays a part.

### 4. Pathways and Biological Processes
ZNF215 is implicated in several biological pathways and processes due to its function as a transcription factor. Some key areas of involvement include:
- **Transcription Regulation:** As ZNF215 encodes a transcription factor, it participates in modulating the expression of target genes necessary for cell proliferation and differentiation.
- **Gene Imprinting:** The gene’s imprinted expression is relevant to studies of genomic imprinting phenomena.
- **Cancer Biology:** Given its association with imprinting disorders, ZNF215 may also be studied for its potential roles in various cancers, particularly those arising from dysregulation of imprinted genes.

Overall, the ZNF215 gene plays a nuanced role in development and disease, particularly in the context of imprinting disorders like Beckwith-Wiedemann syndrome. Ongoing research could uncover more about its contributions to aging and health.