The EPHA4 gene is a critical player in various developmental and physiological processes, particularly in the nervous system. Here are the additional details you requested regarding this gene:

### 1. Associated Genes
EPHA4 interacts with several other genes and proteins, although the summaries provided do not mention them. Notable interactions include:

- **EFNA1** and **EFNB3**: These are ephrin ligands that bind to EPHA4 for signaling.
- **CDK5**: EPHA4 activation leads to the phosphorylation of CDK5, a key regulator in neuronal function.
- **NGEF**: A substrate of CDK5 involved in regulating RHOA, which impacts dendritic spine morphogenesis.
- **CAPRIN1**: Involved in the formation of RNA-protein complexes and affects cytoplasmic domains.
- **ADAM10**: A disintegrin and metalloproteinase that interacts with EPHA4 during cochlear development.

### 2. Aging and Age-Associated Diseases
While direct associations of EPHA4 with aging are less clear, several areas of interest include:

- **Neurodegeneration**: EPHA4 is implicated in neuronal injury repair mechanisms and has been shown to influence axon regeneration, which may be compromised in neurodegenerative diseases.
- **Synaptic Plasticity**: Changes in EPHA4 signaling may contribute to cognitive decline associated with aging, as synaptic plasticity is a fundamental aspect of learning and memory.
- **Angiogenesis**: EPHA4's role in the formation of blood vessels in the central nervous system may be relevant to age-related vascular diseases.
- **Tumor Biology**: EPHA4 has also been associated with various cancers, with its modulation possibly impacting age-related susceptibility to tumors.

### 3. Drug Interactions
Direct drug interactions involving EPHA4 are not well-characterized. However, potential drug classes that may indirectly influence its pathways include:

- **Tyrosine kinase inhibitors (TKIs)**: These could potentially inhibit ephrin receptor activity. Specific compounds targeting the EPHA4 receptor may be under research.
- **Anticancer therapies**: Since EPHA4 is implicated in oncogenic signaling, drugs targeting related pathways (such as those influencing angiogenesis or neural development) may impact its function.

### 4. Pathways and Biological Processes
EPHA4 is involved in several key biological pathways and processes, including:

- **Axon Guidance**: A primary function of EPHA4 is its role in establishing the trajectory of developing axons during nervous system formation.
- **Cell Adhesion**: Mediates integrin-dependent adhesion, impacting morphogenesis and tissue architecture.
- **Neuronal Repair**: Influences axonal repair following injury, which is critical for recovery from neural damage.
- **Synaptic Plasticity**: Involves in long-term potentiation and cognitive functionalities within the nervous system.
- **Angiogenesis**: Plays a role in the formation of new blood vessels, which is essential during development and tissue repair.
- **Thymic Epithelium Development**: Engages in cell-cell signaling impacting immune system development.
  
These features make EPHA4 an essential gene in neurodevelopment and potential therapeutic target in neurodegeneration and cancer. Further research may elucidate its precise functions and regulation in various contexts, particularly related to aging and disease.