### Gene Summary: SNORD113-4

**Gene Symbol**: SNORD113-4  
**Location**: Located in the nucleolus, SNORD113-4 is a small nucleolar RNA (snoRNA) gene that is part of the C/D box snoRNA family. It is involved in the modification of rRNA, primarily by guiding methylation. 

### Associated Genes
While the specific associations of SNORD113-4 have not been extensively characterized, snoRNA genes commonly interact with other ribosomal RNA modification genes. The following genes may be indirectly related due to shared pathways in ribosome biogenesis and RNA modification:
- **RNH1**: Ribonuclease/endonuclease/helicase 1, involved in RNA metabolism.
- **NOP58**: A protein involved in the assembly and stability of snoRNPs (small nucleolar ribonucleoproteins).
- **FBL**: Fibrillarin, a component of snoRNPs involved in rRNA processing.
- Other C/D box snoRNA genes may share regulatory pathways or functions.

### Aging and Age-related Diseases
Currently, there is limited information directly linking SNORD113-4 to aging or specific age-related diseases. However, snoRNAs in general have been implicated in cellular processes related to ribosomal function, which can be affected with age. Misregulation of nucleolar function and snoRNA expression is often observed in age-related pathologies such as:
- **Cancer**: Aberrant expression of snoRNAs has been linked to tumorigenesis and may reflect cellular aging.
- **Neurodegenerative diseases**: Changes in snoRNA levels have been observed in conditions like Alzheimer’s disease.

### Drug Interactions 
As of now, there are no known drugs or drug classes explicitly targeting SNORD113-4. However, given that snoRNAs play roles in RNA modification processes, certain anti-cancer drugs that affect ribosome biogenesis or RNA metabolism may have indirect effects on the expression or function of snoRNAs, including SNORD113-4.

### Pathways and Biological Processes
SNORD113-4 is primarily involved in the following pathways and biological processes:
- **Ribosome biogenesis**: SNORD113-4 plays a role in the modification of rRNA, which is essential for the formation of ribosomes.
- **Methylation of RNA**: It is involved in guiding the methylation of specific ribosomal RNA sites, which is critical for the proper functioning of ribosomes.
- **Nuclear RNA processing**: It is implicated in various aspects of RNA processing within the nucleolus.

In summary, while detailed functional studies and clinical insights regarding SNORD113-4 are limited, the gene appears integral to the fundamental processes of ribosome assembly and RNA modification, with potential implications for understanding its role in aging and related diseases. Research is ongoing to clarify these associations in more detail.