### DEUP1 Gene Overview

**Gene Symbol:** DEUP1  
**Functionality:** DEUP1 is involved in centriole replication and assembly, particularly in multiciliated cells, playing a critical role in the structure of the deuterosome, which is essential for centriole amplification.

### 1. Associated Genes
While the summaries mention in particular interactions with **CEP152** and **PLK4**, other known associated genes may include:
- **PCM1** (Pericentriolar Material 1): Involved in centriole organization.
- **CCDC78** (Coiled-Coil Domain Containing 78): Participates in centriole formation.
- **BBS4** (Bardet-Biedl Syndrome 4): Has been linked to ciliogenesis.
- **TP73**: Known to be connected to cellular response to stress and apoptosis, may influence centriole dynamics.

### 2. Aging and Age-Related Diseases
Research into DEUP1 and its involvement in centriole dynamics suggests a potential connection to age-related conditions:
- **Cellular Senescence:** Deregulation of centriole replication may contribute to cellular senescence, impacting tissue regeneration and organ function.
- **Neurodegeneration:** Abnormalities in cilia and centrioles have been accepted as contributors to neurodegenerative diseases, such as Alzheimer’s disease, given the role of centrioles in neuronal function and maintenance.
- **Cancer:** As DEUP1 is involved in centriole amplification, its dysregulation may lead to unchecked cell division and has been implicated in various cancers.

### 3. Drugs or Drug Classes
Currently, there are no specific drugs or drug classes directly linked to the modulation of DEUP1. However, potential indirect interactions with drugs targeting components of related pathways (such as:
- **Plk4 inhibitors:** Since DEUP1 recruits PLK4, inhibitors of PLK4 may affect DEUP1-associated functions.
- General anti-cancer therapies that target centrosome duplication or cilia-related pathways may also modulate the activity involving DEUP1.

### 4. Pathways and Biological Processes
DEUP1 engages in several pathways and biological processes, including:
- **Centriole Biogenesis:** Plays a crucial role in the formation and duplication of centrioles.
- **Ciliogenesis:** Involved in multiciliated cell differentiation and the production of motile cilia.
- **Cell Cycle Regulation:** As it is linked to centriole replication, DEUP1 participates in maintaining proper cell cycle progression.
- **Cellular Response to Stress:** May interact indirectly with pathways responding to cellular stress, given its structural importance in centrosomal biology.

These associations underline DEUP1's significant role in ensuring proper cell function and its potential implications in pathophysiological conditions related to centriole and cilia dynamics. Further research might illuminate more about the gene's interactions and relevance to diseases, particularly those associated with aging and cellular stress responses.