### KRT84 Gene Overview

**Gene Symbol**: KRT84  
**Chromosomal Location**: 12q13  
**Gene Type**: Protein-coding gene  
**Function**: Encodes a type II hair keratin, which is a component of the keratin protein family and plays a crucial role in the structural integrity of hair and nails.

### 1. Associated Genes
While the NCBI and UniProt summaries mention several keratin genes, other genes that may be associated with KRT84 include:
- **KRT81**, **KRT83**, **KRT82**: Other type II keratins that are adjacent to KRT84 on chromosome 12 and may also contribute to similar structural roles in hair.
- **KRT17**: Though part of a different keratin family, it is significant in skin biology and could interact with pathways related to KRT84.
- **KRTAP24-1**: A keratin-associated protein that interacts with keratin fibers.

### 2. Aging and Age-Related Diseases
Research related to keratin genes, including KRT84, suggests a connection with aging and age-related changes in hair and skin. Some aspects include:
- **Hair Graying and Loss**: Alterations in keratin expression can lead to changes in hair follicle structure, contributing to hair graying and loss often associated with aging.
- **Skin Integrity**: Keratins play roles in maintaining skin barrier function; dysregulation may contribute to age-related skin disorders such as dermatitis and impaired wound healing.
- **Cancers**: Certain keratin genes are implicated in skin cancer; abnormal expression of keratin genes, including KRT84, can be associated with tumorigenesis.

### 3. Drug Interactions
While specific drugs targeting KRT84 are not widely documented, keratin proteins may interact with certain drug classes that affect skin and hair health:
- **Topical Retinoids**: These drugs, used for skin anti-aging and acne treatment, may influence keratin expression patterns.
- **Dexamethasone**: A steroid known to influence keratin production in skin cells.
- **Chemotherapy Agents**: Drugs that affect keratinocytes may alter keratin expression, including in hair keratins like KRT84, during treatment for cancers.

### 4. Pathways and Biological Processes
KRT84 is involved in several biological pathways, including:
- **Keratinization**: This is the process whereby keratinocytes produce keratin, leading to the formation of hair and skin.
- **Cell Structure Organization**: The KRT84 protein contributes to the structural integrity of hair follicles and the epidermis.
- **Regulation of Cell Cycle and Apoptosis**: Keratins can influence keratinocyte differentiation, and alterations in keratin expression can affect cell proliferation and apoptosis in skin cells.

In summary, KRT84 is essential for hair and nail development, and its role extends into implications for aging and potential associative interactions with treatments that influence hair and skin health. Further research may elucidate additional functions, interactions, and implications for health and disease related to KRT84.