### GTF3C6 Gene Overview

**Gene Symbol:** GTF3C6  
**Function:** GTF3C6 is involved in RNA polymerase III-mediated transcription, functioning as an integral component of the TFIIIC2 subcomplex. It has a crucial role in directly binding promoters of tRNA genes and virus-associated RNAs, facilitating the recruitment of RNA polymerase III for transcription initiation.

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### 1. Associated Genes

GTF3C6 is functionally related to several other genes involved in RNA polymerase III (Pol III) transcription and TFIIIC complex assembly. Some of the associated genes may include:
- **GTF3C1**: The largest subunit of the TFIIIC complex, it forms part of the same transcription machinery.
- **GTF3C2**: Another subunit associated with the TFIIIC complex, functioning in mediating Pol III transcription.
- **GTF3C5**: A gene encoding a subunit also known to cooperate with GTF3C6 within the transcriptional complex.

### 2. Details Related to Aging or Age-Related Diseases

While specific research directly linking GTF3C6 to aging or age-related diseases is limited, its role in transcriptional regulation has potential implications:
- **Cellular Stress Response**: Alterations in Pol III transcription are highlighted in age-related decline, as efficient gene expression is crucial for cellular repair and homeostasis.
- **Cancer**: Changes in RNA polymerase activity, including that mediated by GTF3C6, may contribute to oncogenic processes, and cancer incidence increases with age.

### 3. Drug Interactions

Currently, there are limited direct drug interactions specifically linked to GTF3C6. However, studies involving RNA polymerase III and related transcription regulatory blockers might affect GTF3C6 indirectly. Potential areas for drug interactions could include:
- **Cancer Therapies**: As altered transcriptional regulation is involved in many cancers, drugs targeting the transcription machinery (such as specific inhibitors of RNA polymerase III) may have downstream effects on GTF3C6 activity.

### 4. Pathways and Biological Processes

GTF3C6 is involved in several important biological processes, including:
- **RNA Polymerase III Transcription**: Primarily responsible for the transcription of tRNA and other small RNAs critical for protein synthesis.
- **Transcription Regulation**: Plays a vital role in the assembly and function of the TFIIIC complex, thereby affecting the regulation of genes transcribed by RNA polymerase III.
- **Response to Stress**: Given its role in transcription, GTF3C6 may participate in cellular responses to stressors that affect transcription effectiveness.

In conclusion, GTF3C6 is an integral player in the regulation of transcription for genes involved in critical cellular functions, and while direct associations with aging are not abundantly documented, its functional role points to potential relevance in maintaining cellular health across the lifespan. Further studies are needed to elucidate specific relationships with age-associated processes and sarcomas or targeted therapies that could affect its activity.