### KIAA0087 Gene Overview

The KIAA0087 gene, also known by its alternative name **NOC2L (Nucleolar ComplexAssociated 2 Like)**, is located on human chromosome 2. It encodes a protein that is involved in various cellular processes, including ribosome biogenesis.

### 1. Associated Genes
KIAA0087 is often associated with several other genes involved in similar biological processes or pathways. Some related genes include:

- **RPL genes** (e.g., RPL5, RPL22) which encode ribosomal proteins
- **NPM1** (Nucleophosmin) which plays a role in nucleolar function
- **DDX21** (DEAD-Box Helicase 21), involved in RNA metabolism
- **UFC1** (Ubiquitin-Fold Modifier 1) and **UBC** (Ubiquitin-Conjugating Enzymes) which are involved in protein modification processes

### 2. Aging and Age-Related Diseases
KIAA0087 has been implicated in age-related changes primarily through its role in cellular proliferation and ribosome biogenesis. Dysregulation of ribosome biogenesis is known to be associated with several age-related diseases, including:

- **Cancer**: Abnormalities in nucleolar function and ribosome biogenesis are often observed in various types of cancer.
- **Neurodegenerative disorders**: Research has indicated potential links between nucleolar function and diseases like Alzheimer's disease, where alterations in cellular protein synthesis can influence the formation of neurotoxic aggregates.

### 3. Drug Interactions
Currently, there are no specific drugs identified that target KIAA0087 directly; however, since it plays a role in ribosome biogenesis, drug classes that may indirectly affect its function include:

- **Antibiotics**: Certain antibiotics that target ribosomal function may affect genes involved in translation and ribosome assembly.
- **Chemotherapeutic agents**: Drugs that inhibit cellular division and ribosome production could indirectly interact with KIAA0087.

### 4. Pathways and Biological Processes
KIAA0087 is involved in various biological pathways and processes, including:

- **Ribosome Biogenesis:** The protein encoded by KIAA0087 is essential for the assembly of ribosomal components, critical for protein synthesis.
- **Nucleotide Metabolism:** KIAA0087 has been associated with processes that involve rRNA and ribosomal protein functioning.
- **Cell Cycle Regulation:** It may also participate in processes related to cell growth and proliferation.

### Conclusion
The KIAA0087 gene plays a crucial role in ribosomal assembly and cellular functions that have implications for aging and related diseases. While its direct interactions and drug targets require further elucidation, its involvement in major biological processes positions it as a gene of interest in studies of cell biology and aging.