### PPIAL4F Gene Overview

**Gene Symbol:** PPIAL4F  
**Location:** The PPIAL4F gene encodes a protein that is classified as a member of the peptidyl-prolyl isomerase (PPIase) family, known for assisting in the correct folding of proteins by catalyzing the cis-trans isomerization of proline residues in polypeptides. 

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### 1. Associated Genes
While specific interactive or associated gene information for PPIAL4F is less frequently documented, genes related by functional similarity or pathways include:

- **PPIL1**: Another PPIase involved in protein folding.
- **PPIA (cyclophilin A)**: An important member of the PPIase family that assists in protein folding and is tied to immune responses.
- **PPIB**: Also a peptidyl-prolyl isomerase that shares similar functions.

These genes may participate in similar biological processes or pathways but do not necessarily share direct regulatory interactions.

### 2. Aging and Age-Related Diseases
PPIAL4F has not been extensively studied in the context of aging or age-related diseases specifically. However, PPIases, in general, are believed to play roles in protein misfolding and aggregation, which are hallmarks of age-related diseases such as:

- **Alzheimer's Disease**: Protein aggregation and misfolding are implicated in the pathogenesis, and PPIases may influence the folding and aggregation processes.
- **Parkinson's Disease**: Similar misfolding of proteins occurs in Parkinson's, and PPIases may also have protective roles against such processes.

Some PPIases have been associated with cellular stress responses that can be influenced by aging.

### 3. Drug Interactions
PPIAL4F is predicted to bind cyclosporin A, which is a well-known immunosuppressive drug. Drugs or drug classes that may interact with the PPIAL4F gene include:

- **Immunosuppressive agents**: e.g., Cyclosporin A, which inhibits T-cell activation.
- **Antifungal agents**: Some studies suggest a relationship to drugs affecting protein folding (though specifics on PPIAL4F may not be available).

Research on the direct pharmacological interactions specific to PPIAL4F remains limited, as the focus is typically on more prominently characterized PPIases.

### 4. Pathways and Biological Processes
PPIAL4F is implicated in multiple pathways and processes, including:

- **Protein Folding**: Directly involved in assisting protein conformational transitions.
- **Cell Cycle Regulation**: Some PPIases are involved in the regulation of the cell cycle by influencing the folding of signaling proteins.
- **Response to Cellular Stress**: This gene may be part of pathways that respond to stressors affecting protein homeostasis.
- **Signal Transduction**: Aligning with the general roles of PPIases in modulating the activity of various signaling proteins through folding.

In summary, while PPIAL4F provides essential functions related to protein folding via its isomerase activity, additional studies are necessary to elucidate its specific interactions, particularly concerning aging and disease contexts. Further exploration of its pharmacological interactions and network within the cellular environment is also warranted.