**SNORD115-28 Gene Overview**

- **Gene Symbol:** SNORD115-28

**General Description:**
SNORD115-28 is a member of the small nucleolar RNA (snoRNA) family, specifically categorized as a small Cajal body-specific RNA (scaRNA). The SNORD115 gene family is involved in the biogenesis of various ribonucleoprotein complexes, particularly in the modification of rRNA and the regulation of gene expression at the post-transcriptional level. 

### 1. Associated Genes
While direct associations of specific genes with SNORD115-28 may not be extensively documented, snoRNAs, including SNORD115-28, are generally thought to interact with several genes involved in the regulation of RNA metabolism, and may exert effects on:
- **rRNA processing genes:** These include genes like RRP1B and various other snoRNA genes that are involved in ribosome biogenesis.
- **CDK2, GSK3B:** Some studies hint at a regulatory role in genes involved in cell cycle and signaling pathways.
These interactions may be indirect and depend on cellular contexts or specific stimuli.

### 2. Aging and Age-Related Diseases
Currently, limited research explicitly details the involvement of SNORD115-28 in aging or age-related diseases. However, snoRNAs have been implicated in various cellular processes that can affect aging:
- **RNA modification and metabolism:** Changes in snoRNA levels and function, including those from the SNORD115 family, have been linked to age-associated conditions like Alzheimer's disease.
- **Neurodegeneration:** Some studies suggest altered expression of certain snoRNAs, potentially leading to dysregulation of RNA metabolism, may contribute to the molecular pathology of neurodegenerative diseases.

### 3. Drug Interactions
As of the latest information available up to October 2023, there are no specific drugs or drug classes that have been conclusively linked to direct interactions with the SNORD115-28 gene. However:
- **General implications:** Given the role of snoRNAs in ribosome biogenesis and cellular function, there may be indirect interactions with treatments targeting cancer, neurodegeneration, or other diseases impacting cellular RNA processes, although no specific drug targets have been validated.

### 4. Pathways and Biological Processes
SNORD115-28 is known to be involved in several key biological processes, including:
- **Ribosome biogenesis:** Essential for the production of ribosomes, which are crucial to protein synthesis.
- **RNA modification:** It aids in the methylation process of rRNA, which is necessary for the proper function of ribosomes.
- **Cajal body dynamics:** As a scaRNA, it is localized in Cajal bodies and plays a role in the biogenesis and function of these nuclear bodies.

Overall, SNORD115-28 plays a significant role in RNA metabolism and indirectly impacts cellular processes related to growth, development, and possibly age-related changes. Further exploration into its functions may yield more information on its implications in health and disease.