### GTF3C3 Gene Overview

**Gene Basics:**
- **Gene Symbol:** GTF3C3
- **Role:** The gene encodes a protein that is part of the TFIIIC2 complex involved in RNA polymerase III-mediated transcription, specifically for small nuclear and cytoplasmic RNA genes.

### Associated Genes
While specific associations might vary and new data can emerge, previous studies have linked GTF3C3 with several other genes in the context of the TFIIIC complex and RNA polymerase III. Some of these associated genes may include:
- **GTF3C1:** A core component of the TFIIIC complex.
- **GTF3C2:** Another component of the TFIIIC complex that works with GTF3C3.
- **POLR3A & POLR3B:** Subunits of RNA polymerase III which may interact with the TFIIIC complex during transcription initiation.

### Age-related Details
As of the last update in October 2023, there are no direct links established in literature between the GTF3C3 gene and specific aging mechanisms or age-related diseases. However, because it is involved in RNA polymerase III transcription, dysfunction in this gene could have broader implications for cellular processes, potentially influencing aging indirectly through effects on RNA synthesis and cellular homeostasis. Disruption of RNA polymerase III function has been linked to various neurodegenerative conditions and other age-related pathologies, such as cancer, which could suggest a more indirect involvement.

### Drug Interactions 
Current knowledge does not specify any direct drug interactions with the GTF3C3 gene product. However, RNA polymerase III and components of its transcription machinery might be targeted by:
- **Antibiotics:** Such as camptothecin or other molecules that affect ribosomal RNA or tRNA synthesis. 
- **Antiviral drugs:** Since the TFIIIC complex participates in the transcription of viral RNA, antiviral agents may have indirect implications on transcriptional regulation through their effects on RNA polymerase III.

### Pathways and Biological Processes 
GTF3C3 is involved in several biological pathways and processes, particularly:
1. **RNA Polymerase III transcription:** It plays a critical role in recruiting RNA polymerase III to tRNA and small RNA gene promoters.
2. **Transcription regulation:** It is crucial in modulating the transcription of various non-coding RNAs, which are vital for diverse cellular processes such as protein translation and post-transcriptional regulation.
3. **Gene expression:** It contributes to the regulation of gene expression, influencing how cells respond to various internal and external stimuli.

### Conclusion
In summary, GTF3C3 is a significant gene within the RNA polymerase III transcription regulatory framework, influencing the expression of key non-coding RNAs. Although direct associations with aging and drug interactions may not be clearly defined, its role in fundamental biological processes and RNA synthesis makes it an important area of research, particularly in understanding cellular aging and potential therapeutic avenues.