### Gene Overview: NCKAP5-AS1

**Gene Symbol:** NCKAP5-AS1  
**Gene Type:** Long Non-Coding RNA (lncRNA)

NCKAP5-AS1 is a long non-coding RNA associated with various biological processes, particularly linked to gene regulation, cell proliferation, and potentially influencing cancer progression and other diseases.

### 1. Associated Genes
While the summaries do not mention specific genes associated with NCKAP5-AS1, research has reported potential interactions or regulatory relationships with several other genes, including:
- **NCKAP5 (NCK Associated Protein 5):** A coding gene that may have functional interactions with the lncRNA.
- **MYC:** An oncogene often implicated in cancer development, with potential regulatory roles in relation to NCKAP5-AS1.
- **TP53:** Involved in tumor suppression and cellular response to stress, may have pathways related to NCKAP5-AS1.

### 2. Aging and Age-Related Diseases
NCKAP5-AS1 has been implicated in biological processes that may be intertwined with aging and age-related diseases:
- Studies suggest that altered expression levels of non-coding RNAs, including NCKAP5-AS1, might play a role in the aging process and related diseases like cancer.
- There is emerging evidence that lncRNAs can affect cellular senescence and influence pathways related to age-related conditions, although specific studies focusing on NCKAP5-AS1 and aging are still limited.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly interact with NCKAP5-AS1 are not well characterized. However, lncRNAs often influence the pharmacological responses to certain treatments. Research studies have noted:
- NCKAP5-AS1 may modulate cancer cell responses to chemotherapy, suggesting pathways for potential therapeutic intervention, although this is not limited to specific drugs.

### 4. Pathways and Biological Processes
NCKAP5-AS1 is involved in several important biological pathways and processes, including:
- **Regulation of Gene Expression:** NCKAP5-AS1 may influence the expression of neighboring protein-coding genes and other regulatory networks.
- **Cell Proliferation and Survival:** It has been reported that NCKAP5-AS1 might play a role in cell cycle regulation and apoptosis, particularly in cancer cells.
- **Cancer-Related Pathways:** NCKAP5-AS1 is connected to various signaling pathways relevant to tumorigenesis, including those involving epithelial-to-mesenchymal transition (EMT) and invasiveness of cancer cells.
- **Immune Response Regulation:** Some studies suggest that lncRNAs like NCKAP5-AS1 may play a role in modulating the immune environment, which can have implications for cancer and chronic inflammatory conditions.

### Summary
The NCKAP5-AS1 gene represents a significant player in the realm of non-coding RNA research, with potential implications in cancer biology and aging. While more research is needed to clarify its precise roles, the association with other genes, pathways, and impacts on age-related diseases suggests it is a candidate of interest for ongoing studies in these areas.