### YES1 Gene Overview

**Gene Symbol:** YES1  
**Chromosomal Location:** Chromosome 18  
**Function:** Non-receptor protein tyrosine kinase; involved in various cellular processes including growth, survival, apoptosis, cytoskeleton remodeling, and differentiation.

### 1. Associated Genes

Beyond those mentioned in the summaries, YES1 is known to interact with several other genes and proteins, including:

- **PTEN** - Tumor suppressor that plays a critical role in the regulation of the cell cycle.
- **AKT** - A protein kinase involved in signaling pathways that promote cell survival and growth.
- **Ras oncogenes (e.g., HRAS, KRAS)** - They function in the regulation of cell proliferation and survival.
- **FYN** - Another member of the SRC family of kinases, involved in signal transduction.

### 2. Aging and Age-Related Diseases

While specific studies directly linking YES1 to aging are limited, its role in cell survival and apoptosis may suggest implications in age-related diseases. Alterations in tyrosine kinase signaling, including that involving YES1, can affect cellular aging, senescence, and the development of age-related diseases such as cancer. Additionally, its involvement in T-cell migration could influence immune function during aging.

**Potential connections:**
- **Cancer:** Dysregulation of YES1 activity may contribute to tumorigenesis due to its role in cell proliferation and survival.
- **Neurodegenerative Diseases:** Its interaction with proteins related to neuron functioning could suggest potential roles in neurodegenerative disorders.

### 3. Drug Interactions

YES1 can be involved in pathways affected by several drug classes, but specific drugs that directly modulate YES1 activity are less well-characterized. However, some drug classes that may have implications include:

- **Tyrosine Kinase Inhibitors (TKIs):** Pharmacological agents targeting various tyrosine kinases may indirectly influence YES1 activity by modulating upstream signaling pathways. Examples include:
  - **Erlotinib (Tarceva)** - Targets EGFR.
  - **Imatinib (Gleevec)** - Targets BCR-ABL and other kinases.

### 4. Pathways and Biological Processes

YES1 is involved in various biological pathways and processes, including:

1. **Receptor Tyrosine Kinase Signaling Pathway** - Engaged when stimulated by ligands such as EGF, PDGF, and others.
2. **Cell Growth and Survival** - Regulation through interactions with critical survival pathways such as those involving AKT.
3. **Cell Cycle Regulation** - Particularly involvement in the transition from the G1 to the S phase through phosphorylation of CDK4.
4. **Cell Adhesion and Junction Assembly** - Participation in epithelial integrity via interactions with proteins like PARD3 and CTNND1.
5. **Cytoskeleton Organization** - Modulating cytoskeletal dynamics, essential for cell morphology and motility.

Overall, YES1’s tyrosine kinase function connects various signaling pathways essential for normal cellular functions, and its dysregulation could contribute to disease processes, particularly cancer. Further studies may elucidate its role in specific age-related conditions.