### AURKB Gene Summary

**Gene Symbol:** AURKB  
**Location:** This gene is located on chromosome 17 in humans. It encodes a serine/threonine kinase that plays a critical role in cell division, particularly during mitosis and meiosis.

### 1. Associated Genes:
In addition to the genes mentioned in the summary (BIRC5, CDCA8, INCENP, CENPA, etc.), other genes that have been reported to be associated with AURKB through various mechanisms include:

- **BUB1**: Important for proper chromosome segregation.
- **SGO1**: Regulates the activity of the spindle checkpoint.
- **KIF7** and **KIF2C**: Kinesins involved in microtubule dynamics.
- **RACGAP1**: Regulates cytokinesis.
- **CDH1**: Involved in the regulation of the cell cycle.

### 2. Aging and Age-related Diseases:
AURKB has been implicated in various aspects of cellular processes that are crucial in aging and age-related diseases. Key points of interest include:

- **Cell Division and Senescence:** As cells age, the regulation of mitosis becomes increasingly important. Aberrant AURKB function can lead to errors in chromosome segregation and aneuploidy, which are commonly observed in age-related diseases and cancers.
- **Cancer Progression:** Mutations and overexpression of AURKB are often correlated with various cancers (e.g., breast cancer, leukemia), and cancer is recognized as one of the major age-related diseases.
- **Cellular Stress Response:** AURKB has roles in stress response pathways that may influence cellular senescence and apoptosis, key processes in aging.

### 3. Drug Interactions:
AURKB is a well-established target for several anti-cancer therapeutics since its overexpression can contribute to tumorigenesis. Known drug classes that interact with AURKB include:

- **Aurora Kinase Inhibitors:** These are specifically designed to inhibit the activity of Aurora kinases and include compounds such as:
  - **Danusertib (AS703569)**
  - **Barasertib (AZD1152)**
  - **Alisertib (MLN8237)**
- **Chemotherapeutic Agents:** Some traditional chemotherapies may indirectly affect the activity of AURKB due to their impact on cell division and mitotic processes.

### 4. Pathways and Biological Processes:
AURKB is involved in a range of pathways and biological processes, including but not limited to:

- **Cell Cycle Regulation:** Specifically, it plays crucial roles during the M phase of the cell cycle.
- **Mitotic Spindle Assembly Checkpoint:** Ensures proper chromosome alignment and segregation.
- **Cytokinesis:** Critical for final separation of daughter cells.
- **Regulation of Gene Expression:** Through phosphorylation of histones and other chromatin-modifying mechanisms.
- **DNA Damage Response:** Involved in signaling pathways that respond to DNA damage, potentially affecting cell cycle arrest and apoptosis.

Overall, AURKB's functions extend beyond mitosis to influence genomic stability, cellular response to damage, and the maintenance of tissue homeostasis, underlining its importance in development, cancer biology, and possibly aging.