The RRM2 gene, encoding the M2 subunit of ribonucleotide reductase, plays a crucial role in nucleotide metabolism and cellular proliferation. Below are detailed associations and information regarding RRM2:

### 1. Associated Genes:
While the NCBI and UniProt summaries do not specify additional genes directly associated with RRM2, it is known to interact with genes involved in cell cycle regulation, DNA synthesis, and cancer biology. Some relevant genes could include:
   - **RRM1**: The other subunit of ribonucleotide reductase, which works alongside RRM2 to carry out the enzymatic function.
   - **TP53**: Tumor suppressor gene, as RRM2 expression is regulated by p53 in response to cellular stress.
   - **MYC**: A regulator of cell proliferation, which has been shown to positively regulate RRM2 expression.

### 2. Aging and Age-Related Diseases:
RRM2 is implicated in several aging and age-related diseases due to its role in DNA synthesis and repair:
   - **Cancer**: Overexpression of RRM2 is often observed in various cancers, where it promotes tumor growth by enhancing nucleotide availability for DNA replication.
   - **Cellular Senescence**: RRM2 levels decrease in senescent cells, which may affect the cells' ability to proliferate and repair DNA, contributing to aging.
   - **Neurodegenerative Diseases**: There is some evidence that dysregulation of nucleotide synthesis pathways involving RRM2 could be related to neurodegenerative processes.

### 3. Drug Interactions:
Several drugs and drug classes may interact with RRM2, primarily through modulation of ribonucleotide reductase activity:
   - **Hydroxyurea**: A drug known to inhibit ribonucleotide reductase, thereby affecting RRM2’s activity. It is used in chemotherapy and to treat sickle cell anemia.
   - **Gemcitabine**: An antimetabolite drug that also inhibits ribonucleotide reductase and is used in cancer treatment, particularly for pancreatic cancer.
   - **Fludarabine**: An anticancer drug that interferes with DNA synthesis and may also involve pathways related to RRM2.

### 4. Pathways and Biological Processes:
RRM2 is involved in several key biological processes and pathways:
   - **Ribonucleotide Reduction**: The primary function where ribonucleotide reductase catalyzes the generation of deoxyribonucleotides from ribonucleotides.
   - **DNA Synthesis**: It plays a pivotal role in providing deoxyribonucleotides necessary for DNA replication and repair.
   - **Cell Cycle Regulation**: RRM2 expression is tightly regulated during different phases of the cell cycle, particularly during the S phase when DNA synthesis occurs.
   - **Wnt Signaling Pathway**: The protein has been noted to inhibit Wnt signaling, which is crucial in various developmental and cancer-related processes.

### Summary
The RRM2 gene is crucial for nucleotide metabolism, cell growth, and DNA repair, linking it to both cancer biology and aging-related processes. Its associated interactions with other genes, involvement in critical pathways, and interactions with certain drugs highlight its importance in both normal cellular function and disease states.