### Information on ADAM28 Gene

#### General Description
The **ADAM28** gene encodes a member of the **ADAM** (A Disintegrin and Metalloprotease) family of proteins. These membrane-anchored proteins share similarities with snake venom disintegrins and are involved in critical biological processes such as cell-cell and cell-matrix interactions. As a lymphocyte-expressed member of the ADAM family, ADAM28 plays significant roles in immune responses and reproduction. 

#### Associated Genes
ADAM28 is part of a gene cluster on chromosome 8 that includes other ADAM family members. Notable members of this gene cluster include:
- **ADAM1**
- **ADAM2**
- **ADAM7**
- **ADAM9**

Additionally, ADAM28 has been associated with the following genes:
- **FASL** (Fas Ligand): Involved in apoptosis and immune regulation.
- **CD40L** (CD40 Ligand): Important for T-cell activation and signaling.
- Other ADAM family members, particularly those that play roles in sperm maturation and lymphocyte development.

#### Association with Aging or Age-Related Diseases
While specific studies on ADAM28's direct role in aging or age-related diseases might be limited, members of the ADAM family are generally implicated in processes such as inflammation, wound healing, and tissue remodeling, all of which are relevant to aging. Dysregulation of ADAM proteins has been associated with various diseases, including:
- **Cancer:** Altered expression of ADAM proteins has been linked to tumor progression and metastasis.
- **Cardiovascular diseases:** ADAM proteins can play roles in plaque instability and atherosclerosis.
Research indicates that ADAM28 may be involved in processes that influence the immune system's functioning, which often declines with age, impacting the development of age-related diseases.

#### Drug Interactions
As of the information up to October 2023, there are no specific drugs or drug classes explicitly known to target ADAM28, although ADAM family proteases are of interest in drug development due to their roles in various diseases. Drugs influencing the ADAM family may indirectly impact ADAM28's activity.

#### Pathways and Biological Processes
ADAM28 is implicated in several pathways and biological processes, including:
- **Immune System Development:** Involved in lymphocyte migration and immune responses.
- **Ectodomain Shedding:** Participates in the shedding of cell surface proteins, including role in modulating signaling molecules like FASL and CD40L.
- **Spermatogenesis and Sperm Maturation:** Contributes to the processes that occur during sperm development.
- **Cell Adhesion and Extracellular Matrix Interaction:** Plays a role in the adhesion of immune cells, influencing their migration out of the bloodstream and into tissues.

#### Summary
ADAM28 is a critical gene with functional significance in immune and reproductive systems, influencing processes from lymphocyte emigration to sperm maturation. It is involved in various pathways that can impact immune responses and may have indirect implications in age-related diseases due to its role in cell signaling and interaction. Further research is necessary to elucidate the full extent of its functions and potential therapeutic targets.