### FILIP1L Gene Overview

**Gene Symbol:** FILIP1L  
**Location:** Predicted to be located in the cytoplasm, membrane, and nucleus.  

**Protein Summary:** FILIP1L acts as a regulator of antiangiogenic activity in endothelial cells. Its overexpression in these cells results in inhibition of cell proliferation, migration, and an increase in apoptosis. Moreover, FILIP1L is noted for its role in inhibiting melanoma growth when expressed in tumor-associated vasculature.  

### Additional Information

1. **Associated Genes:**
   - Specific gene interactions involving FILIP1L may include genes related to angiogenesis and apoptosis, but comprehensive lists of gene associations often require in-depth genomic analyses (e.g., co-expression, interaction studies). Some literature suggests associations with genes like **VEGFA** (vascular endothelial growth factor A), integral to angiogenesis regulation.
   - Potential involvement with pathways linked to tumor suppressor genes and oncogenic signaling such as **TP53** and related pathways is also relevant but should be further explored through specific interaction mapping studies.

2. **Aging and Age-Related Diseases:**
   - Though direct associations of FILIP1L with aging or age-related diseases aren't widely reported, there may be implications regarding its role in tumor susceptibility and endothelial dysfunction with age. Dysregulation of angiogenesis is known to impact both cancer development and various age-related diseases, such as cardiovascular diseases, where endothelial cell function diminishes over time.
   - Its involvement in apoptosis may also tie into age-related degeneration processes and cellular senescence, but targeted research is needed to elucidate these connections.

3. **Drug Interactions:**
   - While there isn’t a comprehensive list of drugs explicitly targeting FILIP1L, it may indirectly interact with drugs affecting angiogenesis, such as anti-VEGF agents (e.g., **Bevacizumab**) and other targeted therapies in cancer treatment that influence related pathways.
   - Future drug discovery efforts might focus on compounds enhancing or mimicking FILIP1L activity or pathways involved in its function.

4. **Biological Processes and Pathways:**
   - **Key Biological Processes:**
     - Negative regulation of cell proliferation.
     - Apoptotic signaling pathways.
     - Regulation of angiogenesis (antiangiogenic processes).
   - **Pathways:**
     - The **VEGF signaling pathway** is likely relevant, given FILIP1L's role in endothelial cells and its involvement in melanoma inhibition.
     - Potential modulation of other signaling pathways associated with tumor suppression and cell cycle regulation.
     - Cellular stress responses and pathways that promote apoptosis may be influenced by FILIP1L activity.
  
### Conclusion

The FILIP1L gene plays a notable role in regulating angiogenesis and tumor progression. Although further studies may detail its connections with drug interactions, associated pathways, and implications in aging, existing knowledge highlights its potential as a target in therapeutic strategies for cancer and age-related conditions. Overall, additional functional studies and clinical correlations will be essential to fully understand the significance of FILIP1L in these contexts.