### NBPF15 Gene Overview

**Gene Symbol:** NBPF15  
**Location:** Human chromosome 1, primarily in segmental duplications  

#### Summary

The NBPF15 gene is part of the neuroblastoma breakpoint family (NBPF), which consists of numerous closely related genes that have undergone significant duplication events in the human lineage. Characterized by repeating copies of DUF1220 protein domains, this gene is involved in a broad range of biological processes, particularly those related to development and neurogenetic diseases.

### 1. Associated Genes

While specific associations for the NBPF15 gene might not be extensively detailed in the literature, members of the NBPF family (for example, NBPF1, NBPF2, etc.) may share functional roles and pathways. Additionally, genes associated with the neurological and developmental disorders mentioned in the summaries, such as:

- **AUTS2** (associated with autism spectrum disorders and other developmental disorders)
- **CDH15** (associated with neurological connectivity and brain development)
- **SNPs in genes related to schizophrenia** (such as ZNF804A and other risk genes for schizophrenia)

### 2. Aging and Age-Related Diseases

The NBPF family, particularly genes with DUF1220 domains, has been implicated in neurodevelopmental disorders and cognitive functioning, which can correlate with aging. Although specific aging-related studies directly linking NBPF15 to age-related diseases are limited, broader research suggests that alterations in gene expression or copy number variations within this gene family may contribute to cognitive decline, neurodegenerative diseases, and other age-related disorders due to their involvement in brain development and function.

### 3. Drug Interactions

As of the latest information until October 2023, specific drugs or drug classes that interact directly with the NBPF15 gene are not well-documented. However:

- Some studies suggest a potential involvement of DUF1220 domains in cancer progression, hinting at therapeutic areas where targeting NBPF15 might be relevant. 
- As with many genes implicated in cancer, experimental therapeutics could involve:
  - **Antineoplastic agents** (general cancer treatments)
  - **Targeted therapies** based on genetic profiling of tumors where NBPF members are expressed.

### 4. Pathways and Biological Processes

The NBPF15 gene is associated with several important biological processes, including:

- **Neurodevelopment:** Involvement in neuronal development given the neuroblastoma connection and expression patterns in the brain.
- **Cell Proliferation and Differentiation:** Given its association with neuroblastoma, it plays a role in cellular growth and differentiation.
- **Neurogenetic Diseases:** Altered expression has been linked to developmental disorders such as autism, schizophrenia, and cognitive disabilities.
- **Disease Susceptibility:** Variations in gene copy number in the 1q21.1 region are implicated in various congenital anomalies and cancers.

### Conclusion

The NBPF15 gene is a fascinating area of study, particularly in the context of neurodevelopment and genetic disorders. Given its involvement in a variety of pathways and the association with certain diseases, ongoing research is crucial to fully delineate its role in health and disease.