### RMND5A Gene Overview

**Gene Symbol:** RMND5A  
**Location:** Cytoplasm and nucleoplasm  
**Function:** The RMND5A gene encodes a protein that is a core component of the CTLH (C-terminal to LRR and HSP90) E3 ubiquitin-protein ligase complex. It is involved in the selective ubiquitination of substrates for proteasomal degradation and is predicted to have metal ion binding and ubiquitin protein ligase activity.

### 1. Associated Genes
Besides MAEA, which is mentioned in your summaries, RMND5A may also have interactions with or associations to other genes involved in proteasomal degradation and ubiquitin pathways, but specific genes outside the highlights are not extensively documented in the provided text. However, genes involved in ubiquitin-proteasome system like **UBE2H**, which contributes ubiquitin, and additional E3 ligases may also be indirectly associated.

### 2. Aging and Age-Related Diseases
While specific literature linking RMND5A directly to aging or age-related diseases might be limited, the general involvement of ubiquitin-proteasome pathways in cellular maintenance and response to stress could imply a role in aging. Disruptions in ubiquitin-mediated proteolysis have been implicated in neurodegenerative diseases and other age-related conditions. Thus, RMND5A could hypothetically influence these pathways, given its role in protein catabolism.

### 3. Drug Interactions
There are currently no specific drugs or drug classes widely documented in public databases that directly interact with RMND5A. Given its role in the ubiquitination process, it is plausible that compounds affecting E3 ligase activity or general proteasome function could relate indirectly to RMND5A, but explicit interactions would require more specific pharmacological studies.

### 4. Pathways and Biological Processes
RMND5A is involved in several critical biological processes and pathways:
- **Ubiquitin-Dependent Protein Catabolic Process:** RMND5A participates in the tagging and degradation of proteins through the ubiquitin-proteasome system.
- **Protein Polyubiquitination:** Contributes to the addition of multiple ubiquitin molecules onto a substrate, marking it for degradation.
- **Proteasome-Mediated Protein Catabolism:** Engaged in the processing and degradation of proteins via the proteasome pathway.
- **Cell Proliferation:** The catalytic activity of the CTLH E3 ubiquitin-protein ligase complex, facilitated by RMND5A, is essential for normal cell growth and proliferation.

In summary, RMND5A is a versatile gene involved in key cellular processes, particularly those related to ubiquitin signaling and proteolysis, with potential implications in aging and associated diseases, though more research appears necessary to fully elucidate its roles and implications.