### PPIAP77 Gene Overview

**Gene Symbol:** PPIAP77  
**Full Name:** Peptidylprolyl isomerase A-like protein 3 (also referred to as PPIAP77)  
**Gene Type:** Protein Coding

### 1. Associated Genes
While the summaries from NCBI and UniProt do not specify associated genes, PPIAP77 may have functional relationships with genes involved in protein folding, stress response, and cell signaling due to its role as a peptidylprolyl isomerase. Some relevant gene families may include:

- **Cyclophilins:** such as CYPs (Cyclophilin A) that are involved in isomerase activities.
- **Heat Shock Proteins (HSPs):** which aid in protein folding.
- **All associated genes should be confirmed through pathway databases or co-expression analyses.**

### 2. Aging and Age-Related Diseases
As of the latest knowledge updates in October 2023, there is limited direct evidence linking PPIAP77 to aging or specific age-related diseases. However, peptidylprolyl isomerases (PPI) like PPIAP77 are implicated in protein homeostasis, which is a critical factor in cellular aging and the aging process. Disturbances in protein folding and homeostasis are associated with age-related conditions such as neurodegenerative diseases (e.g., Alzheimer’s disease) and various forms of cancer. Further research may be needed to definitively correlate this gene with specific aging processes.

### 3. Drug Interactions
There is no comprehensive list of drugs specifically targeting PPIAP77 available in public databases (as of October 2023). However, drugs that generally inhibit prolyl isomerases or other related pathways may indirectly affect the expression or activity of PPIAP77. Classes of compounds that might be considered include:

- **Immunosuppressants:** which can affect cyclophilins (e.g., Cyclosporin A).
- **Anticancer drugs:** targeting pathways involving protein folding and stress responses.
  
Please consult specialized pharmacogenomics databases for the latest interactions, as new therapeutic agents may emerge that target this gene.

### 4. Pathways and Biological Processes
PPIAP77 is involved in various biological processes and pathways, including:

- **Protein folding:** PPIAP77 assists in the folding of polypeptides by catalyzing the isomerization of proline residues.
- **Regulation of protein activity:** By ensuring proper folding, PPIAP77 may modulate the activity of other proteins, potentially influencing signaling pathways and metabolic processes.
- **Stress response pathways:** As part of the cellular stress response mechanisms, particularly under conditions where heat shock proteins are induced.

To gather further details on specific pathways associated with PPIAP77, users are encouraged to refer to databases such as KEGG, Reactome, and the Gene Ontology (GO) resource, which detail biological pathways and processes with associated genes. 

**Note:** It's essential to stay updated with literature and databases for the most recent insights regarding PPIAP77, as biological understanding is continuously evolving.