The **NCKAP5-AS2** gene, also known as **NCKAP5 antisense RNA 2**, is a long non-coding RNA (lncRNA) that has been studied for its involvement in various biological processes and its potential implications in health and disease.

### 1. Associated Genes
While specific associations may vary across studies, potential interacting or related genes as identified in literature include:

- **NCKAP5**: The sense strand of the NCKAP5-AS2 gene is the NCKAP5 gene, which encodes an adaptor protein involved in various cellular processes.
- Other genes involved in similar pathways or co-expressed with NCKAP5-AS2 include:
  - **WNT5A**: Implicated in developmental processes.
  - **CDH1**: Associated with epithelial adhesion.

Note: The relationships between lncRNAs and other genes can often involve complex regulatory networks, and thus these associations may not indicate direct interactions.

### 2. Aging or Age-Related Diseases
Recent studies have suggested that lncRNAs like NCKAP5-AS2 may play roles in cellular senescence and the regulation of aging. Specific roles in age-related diseases have not been extensively characterized, but potential associations include:

- **Cancer**: Aberrant expression of NCKAP5-AS2 has been linked to various cancers, suggesting a role in tumorigenesis, which is an essential aspect of age-related pathologies.
- **Cardiovascular diseases**: Some studies have pointed towards a role for certain lncRNAs in cardiovascular function and diseases, but direct evidence for NCKAP5-AS2’s involvement may need further research.

### 3. Drug/Drug Classes Interaction
As of now, there are no specified drugs or drug classes directly associated with the NCKAP5-AS2 gene. However, since lncRNAs often influence pathways tied to drug metabolism and action indirectly, potential pharmacological relevance may exist but typically requires more investigation.

### 4. Pathways and Biological Processes
NCKAP5-AS2 is involved in several biological processes, including:

- **Regulation of Gene Expression**: Long non-coding RNAs are known to act in the regulation of transcriptional and post-transcriptional processes.
- **Cellular Signaling Pathways**: It may play a role in key signaling pathways such as the Wnt signaling pathway, which is essential for various developmental and physiological processes.
- **Cell Proliferation and Migration**: In certain contexts, studies have indicated that NCKAP5-AS2 may affect cell proliferation and motility, which are critical in development and cancer metastasis.

### Summary
The NCKAP5-AS2 gene is a member of the long non-coding RNA family with potential implications in cancer and possibly age-related diseases. Although associations with specific drugs are not well established, it is implicated in various biological processes and signaling pathways. Further research is necessary to better understand its functions and potential therapeutic targets.