### ARL14EPL Gene Overview

**Gene Symbol:** ARL14EPL  
**Aliases:** ARL14, ARL14EPL

**Protein Summary:** The ARL14EPL gene encodes a member of the ADP-ribosylation factor-like (ARL) protein family, involved in cellular signaling processes. ARL proteins are small GTPases that have been implicated in processes such as vesicle trafficking, cytoskeletal dynamics, and cell signaling.

### 1. Associated Genes
While specific lists of associated genes may not always be comprehensive, ARL14EPL has been linked with several other genes involved in similar or related biological functions. Some examples include:

- **ARL14**: The canonical member of the ARL14 family.
- **RAB5**: Known for its role in endocytosis and vesicle trafficking.
- **RHOA**: Influences cytoskeletal organization and cell signaling.
- **RAC1**: Involved in the regulation of actin cytoskeleton.

### 2. Aging and Age-Related Diseases
ARL14EPL's role in cellular signaling suggests potential implications in aging and age-related diseases. Though specific studies linking ARL14EPL directly to aging or age-related diseases are limited, small GTPases like ARL14EPL are generally known to be vital in cellular functions altered in aging and associated pathologies. For instance:

- **Neurodegenerative Diseases**: Dysregulation of GTPases, which includes members of the ARL family, has been associated with diseases such as Alzheimer’s and Parkinson’s disease.
- **Cancer**: Altered signaling pathways involving small GTPases have implications in cancer progression and metastasis.

### 3. Drug Interactions
Currently, specific drugs or drug classes directly targeting ARL14EPL are not particularly well-documented. However, given the role of GTPases in various signaling pathways, it is plausible that drugs influencing cellular signaling (such as those affecting phosphoinositide pathways or cytoskeletal dynamics) may indirectly interact with the pathways involving ARL14EPL.

### 4. Pathways and Biological Processes
ARL14EPL is involved in numerous cellular pathways and biological processes, which may include but are not limited to:

- **Vesicle Transport**: Plays a role in the trafficking of vesicles within cells.
- **Cell Proliferation**: Involved in signaling pathways that regulate cell growth and division.
- **Actin Cytoskeleton Dynamics**: Contributes to the remodeling of the cytoskeleton, affecting cell shape and motility.
- **Signaling Pathways**: May participate in pathways related to the Ras signaling network, contributing to various cellular responses to external stimuli.

### Summary
In summary, ARL14EPL is an important gene within the ARL protein family, with functions that may influence cellular processes tied to aging and contribute to diseases. Its connections to other genes involved in trafficking, cytoskeletal dynamics, and signaling pathways suggest roles in maintaining cellular integrity and function. Further research may clarify specific drug interactions and the gene’s implications in age-related conditions.