### ARL4C Gene Overview

**Gene Symbol:** ARL4C  
**Full Name:** ADP-ribosylation factor-like 4C  
**Gene Family:** ADP-ribosylation factor (ARF) family of GTP-binding proteins  

#### Functional Summary
ARL4C is implicated in various cellular processes through its ability to cycle between inactive GDP-bound and active GTP-bound states. This cycling is influenced by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Notably, ARL4C has a high guanine nucleotide exchange rate and a nuclear localization signal, suggesting roles in both cytoplasmic and nuclear processes. The protein is not an allosteric activator of cholera toxin but may participate in cholesterol transport, particularly linked to the ABCA1-mediated cholesterol secretion pathway.

### 1. Associated Genes 
While ARL4C is closely related to ARL4A and ARL4D, it may also have functional interactions with the following genes:
- **ABCA1:** Involved in cholesterol and phospholipid transport.
- **CYTH1, CYTH2, CYTH3, CYTH4:** Cytohesins that are recruited to the plasma membrane by ARL4C in its GDP-bound form, indicating a role in vesicular transport.

### 2. Aging and Age-Related Diseases
While specific studies connecting ARL4C directly to aging or age-related diseases are limited, GTP-binding proteins, including members of the ARF family, often have roles in cellular processes such as membrane traffic, signal transduction, and metabolism which are critical in aging. Aberrations in these processes can contribute to age-related conditions such as neurodegenerative diseases, cardiovascular diseases, and metabolic disorders. Further research may elucidate more direct connections.

### 3. Drug Interactions
As of the latest data, there are no specific drugs or drug classes directly targeting ARL4C reported in major pharmacological listings. However, given its roles in pathways influenced by cholesterol and vesicle transport, drugs targeting related pathways (e.g., statins for cholesterol management, or general modulators of vesicular transport) may indirectly influence ARL4C activity.

### 4. Pathways and Biological Processes
ARL4C is involved in several key biological processes, including:
- **Cholesterol Transport:** Its interaction with ABCA1 suggests a role in intracellular cholesterol processing and secretion.
- **Microtubule-Dependent Transport:** Involvement in vesicular transport processes, specifically in the movement of vesicles from early endosomes to recycling endosomes.
- **Regulation of Membrane Dynamics:** Its action relaying information on membrane vesicle cycling impacts cellular signaling and homeostasis.

Overall, ARL4C is a critical component in cellular transport mechanisms and could play a broader role in metabolic regulation, potentially implicating it in broader paths related to health and aging. Further studies may refine its roles and associations within human health and diseases.