### ANAPC15 Gene Overview

**Gene Symbol**: ANAPC15 (also known as ANAPC15, APC15, or APC component 15)

#### 1. Associated Genes
ANAPC15 is part of a larger complex and interacts with several key regulators of the cell cycle. Some associated genes include:
- **CDC20**: A major co-activator of the anaphase-promoting complex (APC/C).
- **CCNB1**: Cyclin B1, involved in regulating the cell cycle; targets for degradation by the APC/C.
- **CCNA2**: Cyclin A2, which is also regulated by the APC/C.
- **BUB1**: A mitotic checkpoint kinase that helps maintain genomic integrity.
- **MAD2L1**: Another component of the mitotic checkpoint, which is part of the MCC that prevents premature anaphase by inhibiting APC/C.

#### 2. Aging and Age-Related Diseases
While specific research directly linking ANAPC15 to aging or age-related diseases may be limited, it is known that the anaphase-promoting complex/cyclosome (APC/C) plays a critical role in regulating the cell cycle and proteolysis. Dysregulation of APC/C has been implicated in various age-related issues, including cancer and neurodegenerative diseases. Accumulated errors in mitotic regulation can contribute to chromosomal instability, a hallmark of aging cells and cancer progression. Moreover, defects in proteins involved in the APC/C can lead to aneuploidy, observed in many age-associated disorders.

#### 3. Drug Interactions
As of the latest knowledge cutoff in October 2023, specific drugs that directly target ANAPC15 have not been widely documented. However, several classes of cancer therapeutics may indirectly influence the activity of the APC/C, including:
- **Proteasome inhibitors**: Such as bortezomib, which disrupt protein degradation pathways and may alter cell cycle regulation.
- **Chemotherapeutic agents** (like taxanes or vinca alkaloids) that affect microtubule dynamics and may lead to changes in APC/C function indirectly by affecting mitosis and the spindle assembly checkpoint.

#### 4. Pathways and Biological Processes
ANAPC15 is involved in several key biological pathways and processes, including:
- **Cell Cycle Regulation**: Central to the transition across different phases of the cell cycle, notably mitosis and G1 phase.
- **Ubiquitin-Proteasome System**: Functions as an E3 ubiquitin ligase, facilitating the ubiquitination and degradation of specific cell cycle regulators, thereby controlling protein levels necessary for proper cell cycle progression.
- **Mitotic Checkpoint Signaling**: Helps ensure that cells do not enter anaphase until all chromosomes are correctly attached to the spindle apparatus, thereby preventing aneuploidy.
- **Spindle Assembly Checkpoint**: Involved in the response to spindle assembly defects by mediating the turnover of the mitotic checkpoint complex, ensuring accurate chromosome segregation.

### Summary
ANAPC15 is a crucial component of the anaphase-promoting complex/cyclosome (APC/C) that regulates the mitotic cell cycle and checkpoint processes. It interacts with various cell cycle regulators and plays a pivotal role in maintaining genomic stability. While its direct associations with aging and disease processes are still being deciphered, its function in the cell cycle makes it a potential player in age-related pathologies, most notably cancer. Further research is needed to elucidate specific drug interactions and detailed aging-related mechanisms.