### EPN2-AS1 Gene Overview

**Gene Symbol:** EPN2-AS1

EPN2-AS1, also known as EPN2 antisense RNA 1, is a long non-coding RNA (lncRNA) located on chromosome 19. Although its primary function is not entirely characterized, lncRNAs like EPN2-AS1 are known to play roles in gene regulation, chromatin remodeling, and cellular processes.

#### 1. Associated Genes
EPN2-AS1 has been implicated in various molecular pathways and may be associated with several other genes, particularly those involved in cancer and immune responses. Although specific genes are not commonly mentioned in existing summaries, it's important to investigate gene expression studies that may reveal potential interactions. Some likely candidates include:

- **EPN2 (Epsin 2):** As a gene from which EPN2-AS1 is derived, it is directly associated with the lncRNA and may share regulatory pathways.

There may also be associations with genes involved in cellular stress responses, immune modulation, or tumorigenesis, but specific genes beyond EPN2 require further study.

#### 2. Aging and Age-Related Diseases
While specific studies explicitly linking EPN2-AS1 to aging or age-related diseases are limited, lncRNAs generally have emerging roles in cellular senescence and age-associated pathologies. Changes in expression levels of lncRNAs, including EPN2-AS1, have been suggested in various studies focused on cancer, neurodegeneration, and cardiovascular disease, which are prominent in aging populations. 

Future research may provide insights into whether EPN2-AS1 acts as a regulatory player in these contexts.

#### 3. Drug Interactions
As of the latest available data, there are no specific drugs or drug classes directly known to interact with EPN2-AS1. However, certain cancer therapies, particularly those targeting lncRNA pathways or epigenetic regulators, may indirectly impact its expression or function. Continued research in pharmacogenomics might clarify potential interactions.

#### 4. Pathways and Biological Processes
EPN2-AS1 is thought to be involved in various biological processes, reflecting the typical roles of lncRNAs:

- **Regulation of Gene Expression:** It likely modulates the transcription of neighboring genes, including EPN2.
- **Chromatin Remodeling:** EPN2-AS1 may influence chromatin structure and dynamics, thereby affecting gene accessibility.
- **Cellular Defense Mechanisms:** Some lncRNAs are involved in the cellular response to stress and inflammation, which could include pathways relevant to immune responses.
- **Cancer Biology:** Given associations with oncogenes and tumor suppressors, EPN2-AS1 may be implicated in pathways regulating cell proliferation, apoptosis, and metastasis.

### Conclusion
EPN2-AS1 is a long non-coding RNA that holds potential significance in gene regulation and disease pathology. Although information on specific associations with other genes or drug interactions remains limited, its involvement in aging and disease processes warrants further investigation to elucidate its functional implications. Ongoing studies are necessary to provide deeper insights into the biological relevance of EPN2-AS1, particularly in the context of age-related health challenges.