**SNORA27 Gene Summary:**

**Gene Symbol:** SNORA27  
**Also Known As:** Small nucleolar RNA, C/D box 27 (snoRNA)  
**Function:** SNORA27 is a small nucleolar RNA which belongs to a class of non-coding RNAs involved in the modification and processing of ribosomal RNA (rRNA) and other small nuclear RNAs. These snoRNAs typically guide the chemical modifications, such as methylation and pseudouridylation, of rRNAs and proteins involved in ribosome biogenesis.

### 1. Associated Genes:
While specific gene associations for SNORA27 may not be extensively documented, small nucleolar RNAs often have related genes involved in ribosome biogenesis, rRNA processing, and nucleotide metabolism. Commonly associated genes for snoRNAs in general may include those encoding other snoRNAs (such as SNORDs) and genes involved in rRNA maturation, like the following:

- **NOL5A**: Nucleolar protein involved in maintaining cell growth and division.
- **FBL**: Nucleolar protein that associates with snoRNA biogenesis.

### 2. Aging and Age-Related Diseases:
Research into small nucleolar RNAs suggests potential roles in cellular aging and the regulation of longevity through their involvement in ribosome biogenesis and overall cellular function. While specific studies detailing SNORA27's direct implication in aging or age-related diseases may be limited, disruptions in snoRNA function can contribute to cellular senescence and age-related pathologies by affecting protein synthesis. Dysregulation may also play a role in conditions associated with cellular stress, which is often increased in the context of aging.

### 3. Drug Interactions:
As of the current state of knowledge, there are no specific drugs directly targeting or interacting with SNORA27 identified in databases. However, because small nucleolar RNAs are often implicated in cellular processes that could be targeted within broader therapy frameworks, drugs that influence ribosome biogenesis and overall cellular health might indirectly affect snoRNA function. Drugs impacting pathways associated with RNA metabolism, such as those targeting oncogenic processes, might modulate SNORA27 activity by affecting the cellular milieu in which it operates.

### 4. Pathways and Biological Processes:
SNORA27 is primarily involved in:

- **Ribosome Biogenesis**: Participating in the synthesis and modification of rRNA, SNORA27 plays a role in the assembly of the ribosomal subunits necessary for protein synthesis.
- **RNA Modifications**: Acting as a guide for 2’-O-ribose methylation, it is involved in the modification of rRNA, which is vital for proper ribosome function.

Moreover, as a member of the snoRNA family, it contributes to the wider processes of:

- **Gene Expression Regulation**: By influencing ribosomal activity and efficiency, this gene is indirectly linked to the regulation of gene expression at the translational level.
- **Cellular Stress Responses**: Variations in snoRNA expression profiles have been associated with stress responses, often enhanced in aging or disease contexts.

In conclusion, while SNORA27 and its functional implications are characterized by involvement in fundamental cellular processes such as ribosome biogenesis and RNA modification, detailed investigations into specific disease associations, direct drug interactions, and its role in aging remain areas open for exploration.