### PPIE Gene Overview

**Gene Symbol:** PPIE  
**Location:** Chromosome 1  
**Function:** The PPIE gene encodes a protein that possesses peptidyl-prolyl cis-trans isomerase (PPIase) activity, aiding in protein folding. It is also involved in RNA-binding and acts as a component of the spliceosome, participating in pre-mRNA splicing. The protein binds specifically to single-stranded RNA, particularly favoring poly-A and poly-U sequences, which are commonly found in the poly(A) region of mRNA.

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### 1. Associated Genes:
- **KMT2A (MLL):** PPIE inhibits the activity of KMT2A, suggesting a regulatory interaction relevant for gene expression and chromatin modification.
- **Other spliceosome components:** While specific partners are not usually directly mentioned in overviews, other genes involved in RNA splicing may also be functionally associated.
- **CYP Family:** Other cyclophilin-like proteins may share functional domains or activities with PPIE.

### 2. Aging and Age-Related Diseases:
- **Cellular Senescence:** Dysregulation of splicing factors, including PPIE, has been correlated with cellular senescence, a condition that is linked to aging.
- **Neurodegenerative Diseases:** Given its role in RNA binding and protein folding, PPIE may also be implicated in age-related neurodegenerative disorders, although specific studies directly linking PPIE to such diseases are limited.
- **Cancer:** Alterations in splicing factors and their functions, including that of PPIE, have been shown to be associated with various types of cancer, a condition that espouses both age and cellular dysregulation.

### 3. Drug Interactions:
- **Cyclosporin A:** Although primarily known for inhibiting cyclophilins, specific interactions with PPIE are not well-defined and highlight general PPIase interactions.
- **Immunosuppressants:** Some drugs targeting other PPIases may indirectly modulate PPIE activity due to shared mechanisms.

### 4. Pathways and Biological Processes:
- **RNA Splicing:** PPIE is a key component of the spliceosome, essential for the processing of pre-mRNA into mature mRNA.
- **Protein Folding:** Through its PPIase activity, it assists in protein conformation by isomerizing proline residues, critical for proper protein structure and function.
- **Cellular Response to Stress:** PPIE may play a role in the cellular stress response, helping to refold misfolded proteins and facilitating cell survival under adverse conditions.
- **Regulation of Gene Expression:** In light of its interaction with KMT2A and involvement in RNA processes, PPIE is thought to have a regulatory role in chromatin dynamics and transcriptional regulation.

### Conclusion:
The PPIE gene is vital for functions related to protein folding and mRNA processing, with implications for aging and age-related diseases through its involvement in splicing and cellular stress responses. Further research may elucidate its full role in various biological and pathological contexts, including potential therapeutic targeting.