The COMMD6 (COMM domain containing 6) gene is a member of the COMMD family of proteins and plays a significant role in cellular signaling and regulation. Below is a detailed overview, including the additional information you requested.

### Additional Information about COMMD6

#### 1. Associated Genes
COMMD6 is known to interact and associate with several other genes and proteins, including:
- **COMMD1:** Another member of the COMM domain-containing protein family, COMMD1 has been shown to affect the same cullin-RING E3 ubiquitin ligase (CRL) complexes as COMMD6.
- **NFKB1:** As indicated in the summaries, COMMD6 acts as a negative regulator of NF-κB signaling, specifically inhibiting NFKB1 activation.
- **CULLIN:** A core component of CRL complexes that COMMD6 may modulate.

#### 2. Aging and Age-Related Diseases
While specific studies directly linking COMMD6 to aging or age-related diseases are limited, it is known that dysregulation in NF-κB signaling is associated with various age-related diseases, including:
- **Inflammation:** Chronic inflammation is a hallmark of aging, and since COMMD6 down-regulates NF-κB activity, it may influence inflammatory processes in aging.
- **Cancer:** Aberrant regulation of the NF-κB pathway, which can be influenced by COMMD6, is also implicated in various types of cancer, particularly those more prevalent in older adults.
- **Neurodegeneration:** There is a potential link between the modulation of NF-κB by COMMD6 and neurodegenerative disorders, which are often age-related.

#### 3. Drug Interactions
There is limited direct information regarding specific drugs interacting solely with COMMD6. However, since it modulates the NF-κB pathway, it may indirectly interact with:
- **Anti-inflammatory drugs:** Such as non-steroidal anti-inflammatory drugs (NSAIDs), which might affect the NF-κB pathway.
- **Immunomodulatory therapies:** Drugs used in conditions involving NF-κB dysregulation could potentially be influenced by COMMD6 activity.

#### 4. Pathways and Biological Processes
COMMD6 is involved in several critical pathways and biological processes, including:
- **NF-κB Signaling Pathway:** Primarily known for its role in immune responses, inflammation, and cell survival.
- **Ubiquitin-Proteasome Pathway:** By modulating CRL complexes, COMMD6 influences protein ubiquitylation and degradation.
- **Cellular Response to Stress:** COMMD6 may also play a role in how cells respond to various stressors, including oxidative stress, which is relevant in aging.

#### Summary
In summary, COMMD6 is a multifunctional protein significant for its role in modulating the NF-κB signaling pathway and impacting the activity of ubiquitin ligase complexes. Its connections to inflammation, aging, and cancer make it a gene of interest in various biological contexts. Further studies may elucidate additional roles and therapeutic implications for COMMD6 in age-related conditions and diseases.