### ZYG11A Gene Overview

**Gene Symbol**: ZYG11A  
**Chromosomal Location**: Human chromosome 1q32.1  
**Gene Type**: Protein-coding

**Function**: The ZYG11A gene encodes a protein that is predicted to be part of the Cullin 2 (Cul2)-RING ubiquitin ligase complex. This protein likely functions as a target recruitment subunit, playing a crucial role in ubiquitin-mediated protein degradation.

### 1. Associated Genes
While specific associations with other genes may not be detailed in the provided summaries, several genes related to the ubiquitin-proteasome system or cellular stress responses could be associated with ZYG11A, including:

- **CULLIN2 (CUL2)**: A core component of the E3 ubiquitin ligase complex.
- **ELONGIN B and C (ELOB, ELOC)**: Also part of the E3 ligase complex that interacts with ZYG11A.
- **UBE2E1, UBE2E2, and other Ubiquitin-conjugating enzymes**: These may interact during the ubiquitination process.

### 2. Aging or Age-related Disease Associations
There are limited direct studies focusing explicitly on ZYG11A and its role in aging or age-related diseases. However, as part of the ubiquitin-proteasome system, alterations in its expression or functioning may play a role in:

- **Cellular senescence**: Proteins regulated by ubiquitination, including those related to cell cycle and stress responses, are crucial in senescence.
- **Neurodegenerative diseases**: The dysfunction of ubiquitin-proteasome pathways has been implicated in conditions such as Alzheimer’s and Parkinson’s disease.

Thus, while a direct link to specific aging-related phenotypes might not be specifically established for ZYG11A, its involvement in fundamental cellular processes suggests a potential role in aging and related pathologies.

### 3. Drug or Drug Classes Interacting with ZYG11A
Currently, there are no specific drugs directly targeting ZYG11A mentioned in the literature. However, as part of the ubiquitin-proteasome system, compounds that manipulate these pathways may indirectly affect ZYG11A activity, including:

- **Proteasome inhibitors**: Such as bortezomib, which may alter the substrate availability for E3 ligases including those involving ZYG11A.
- **Small molecule modulators** of ubiquitination processes: These could affect the ubiquitination pathway in which ZYG11A is involved.

### 4. Pathways and Biological Processes
ZYG11A is involved in several key biological processes:

- **Ubiquitin-mediated proteolysis**: ZYG11A is a crucial mediator in the ubiquitin-proteasome pathway, aiding in the degradation of specific substrates tagged with ubiquitin.
- **Cellular response to oxidative stress**: The regulation of proteins involved in oxidative stress responses may also implicate ZYG11A.
- **Cell cycle regulation**: The degradation of cyclins and cyclin-dependent kinase inhibitors is vital for proper cell cycle control, which can involve ZYG11A.
- **APC/C-mediated degradation**: Involvement in the anaphase-promoting complex/cyclosome during cell division processes.

### Summary
The ZYG11A gene encodes a crucial component of the E3 ubiquitin ligase complex, implicated broadly in cellular regulation processes such as growth, stress responses, and protein homeostasis. Its role in regulations surrounding aging and potential disease contexts may warrant further exploration to elucidate more specific functions and therapeutic targets.