### ACTL7A Gene Overview

**Gene Symbol:** ACTL7A  
**Location:** Chromosome 9q31

**Function:** 
The protein encoded by the ACTL7A gene is an actin-related protein (ARP), and it shares significant sequence similarities with conventional actins. It has an actin fold and an ATP-binding cleft, which are common features of both actins and ARPs. While the exact function of ACTL7A is not fully elucidated, it may play a significant role in the formation and fusion of Golgi-derived vesicles during acrosome biogenesis, which is important for sperm development and function.

### 1. Associated Genes
ACTL7A is located near ACTL7B in the familial dysautonomia candidate region on chromosome 9q31. While the summaries specify that ACTL7A is not involved in familial dysautonomia, the proximity to ACTL7B suggests potential functional or regulatory relationships, though there may be other genes in this genomic region that could be relevant. Specific additional genes directly associated with ACTL7A are not well established in the literature. Therefore, interrelations with other genes could include those involved in general actin dynamics or spermatogenesis.

### 2. Aging and Age-related Disease Associations
The summaries do not provide specific information regarding the associations of the ACTL7A gene with aging or age-related diseases. However, since the gene is involved in cellular processes like vesicle transport and cellular remodeling, it may theoretically play a role in age-related cellular dysfunction. As cellular transport and metabolism often decline with age, further research could elucidate any connections to aging, although no direct associations have been established in the current literature.

### 3. Drug Interactions
As of the latest updates, there are no known drugs or drug classes that explicitly target or interact with the ACTL7A gene. However, due to its role in cellular processes, actin dynamics could indirectly involve various drugs, particularly those affecting cytoskeletal functions or vesicle transport, such as:

- **Microtubule inhibitors (e.g., Paclitaxel) and other cytoskeletal-targeting agents:** These may not directly target ACTL7A, but could influence pathways in which actin-related proteins are involved.

### 4. Pathways and Biological Processes
ACTL7A is involved in several pathways and biological processes, which include, but may not be limited to:

- **Acrosome Biogenesis**: Essential for proper sperm function and fertilization outcomes.
- **Vesicle Transport**: Implicated in the transport mechanisms of cellular organelles.
- **Actin Filament Organization**: Participates in the dynamics of actin filament assembly and disassembly.
- **Cell Motility and Migration**: Influences cellular movement, which could impact processes like development and tissue repair.
- **Nuclear Migration**: Involved in the movement of the nucleus during cell division processes.

### Conclusion
ACTL7A is a fascinating member of the actin-related protein family with significant involvement in cellular processes crucial for spermatogenesis and vesicle transport. Ongoing research may uncover more about its precise functions, contributions to aging, and relationships with pharmacological agents, as well as its broader implications in health and disease.