### CCP110 Gene Overview

**Gene Symbol:** CCP110  
**Function:** Involved in centriole replication, negative regulation of cilium assembly, and regulation of cytokinesis. Essential for proper centrosome duplication at various stages of procentriole formation. Decreased formation of cilia due to its capping action at the mother centriole in collaboration with CEP97.

---

### 1. Associated Genes
CCP110 has been reported to interact or functionally associate with several other genes involved in similar biological processes, including:

- **CEP97:** A known interactor that works with CCP110 to regulate ciliogenesis by capping the mother centriole.
- **CALM1:** A protein that, along with CCP110, plays a role in regulating cytokinesis and genome stability.
- **CETN2:** Co-operates with CCP110 in maintaining spindle integrity during cell division.
- Additional interactions with centrosomal proteins, microtubule-associated proteins, and other centriole or ciliary-related genes may be relevant, though specific names outside those mentioned might require more detailed exploration through interaction databases.

---

### 2. Aging and Age-Related Diseases
CCP110 has been implicated in various aspects of cellular and organismal aging, particularly associated with the following:

- **Ciliopathies:** These are disorders caused by dysfunctional cilia, and since CCP110 negatively regulates cilia formation, mutations or dysregulation could potentially lead to ciliopathies, which often have age-related phenotypes.
- **Cancer:** Altered expression or function of CCP110 may influence tumorigenesis due to its roles in cytokinesis and maintaining genomic stability, a critical factor in cancer progression. Abnormal centriole function is a noted feature in various cancers.
- **Neurodegenerative Diseases:** Ciliogenesis and centrosome stability have been implicated in neurodegeneration; therefore, age-related decline in CCP110 function could hypothetically link to diseases like Alzheimer's.

---

### 3. Drug Interactions
While there are no specific drugs directly targeting CCP110 known as of October 2023, the following drug classes may indirectly relate to its functions due to their effects on the cytoskeleton, cell division, or ciliary function:

- **Microtubule Inhibitors:** Such as taxanes (e.g., paclitaxel), which could affect centriole dynamics and spindle formation processes.
- **Cilia Regulatory Compounds:** Investigational compounds targeting pathways involved in ciliogenesis or centriole maturation may show interactions or effects that relate to CCP110 functionality in research contexts.

Given the gene's involvement in pathways critical for cell division and stability, any compounds influencing these pathways should be studied further for potential interaction.

---

### 4. Pathways and Biological Processes
CCP110 is involved in several key cellular pathways and biological processes:

- **Centrosome Cycle:** Essential for proper centrosome duplication and organization.
- **Ciliogenesis:** Plays a dual role in regulating the assembly and disassembly of cilia by controlling the capping of centrioles.
- **Cytokinesis:** Critical for the successful division of cells, ensuring proper chromosomal segregation and spindle alignment.
- **Cell Cycle Regulation:** Involved in maintaining genomic integrity during cell division through interactions with other regulatory proteins.
- **Endosomal Pathways:** May also influence the fusion of recycling endosomes to basal bodies, especially relevant during cilia formation.

Research into CCP110 continues to evolve, revealing its multifaceted roles in cellular processes critical for development and function in various tissues.