### ERICH5 Gene Summary

**Gene Symbol:** ERICH5  
**Gene Name:** Glutamate receptor interacting protein 1 (ERICH5)  
**Location:** Chromosome 5 (5q31.1)

**Overview:**
The ERICH5 gene encodes a protein that is involved in the regulation of glutamate receptors, specifically playing a role in the glutamatergic signaling pathway. It has been studied in contexts related to synaptic function and neuronal signaling.

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### 1. Associated Genes
ERICH5 has been reported to be associated with several other genes, including but not limited to:
- **GLU (Glutamate receptors):** Genes encoding various subtypes of glutamate receptors, which interact with ERICH5.
- **SHANK Family Genes (e.g., SHANK1, SHANK2, SHANK3):** These genes code for scaffolding proteins that interact with glutamate receptors.
- **PSD95:** A postsynaptic density protein that plays a role in synaptic signaling and interacts with glutamate receptors.

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### 2. Aging and Age-Related Diseases
While specific studies connecting ERICH5 to aging or age-related diseases are limited, glutamate signaling is known to play a crucial role in both neurodegenerative diseases (such as Alzheimer’s disease and Parkinson's disease) and various age-related cognitive declines. Thus, alterations in ERICH5 expression or function may potentially contribute to the pathogenesis of these conditions.

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### 3. Drug Interactions
Currently, there is no specific list of drugs that directly target ERICH5; however, it may be indirectly influenced by drugs that modify glutamate receptor activity such as:
- **NMDA Antagonists:** E.g., Memantine (used in Alzheimer's treatment).
- **AMPA Receptor Modulators:** Drugs affecting AMPA receptor signaling may also have downstream effects on proteins like ERICH5.

Since ERICH5 is involved in synaptic signaling, any pharmacological agents modulating glutamate neurotransmission could theoretically interact with or impact its pathway.

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### 4. Pathways and Biological Processes
ERICH5 is involved in several key biological processes and pathways, including:
- **Glutamate Receptor Signaling Pathway:** Involved in the synaptic transmission of excitatory signals in the nervous system.
- **Neurotransmitter Release:** The protein plays a role in the modulation of neurotransmitter release, specifically related to excitatory neurotransmitters.
- **Synaptic Plasticity:** It contributes to processes underlying learning and memory, notably long-term potentiation (LTP).
- **Cell Communication:** Participates in the signaling pathway that facilitates communication between neurons.

### Conclusion
ERICH5 is a gene critical for proper glutamate signaling and synaptic function. While direct links to specific aging-related processes are still being explored, its role in neurotransmission suggests potential implications for neurodegenerative diseases and age-related cognitive impairment. Further research is warranted to clarify its complete expression profile, interactions, and implications in health and disease.