The RPF2 gene (Ribosome Protein Family 2) is a critical gene involved in ribosomal biogenesis and has important implications in cellular processes. Here are the details you requested:

### 1. Associated Genes
While there are no specific genes universally recognized as directly associated with RPF2 itself, it is known to cooperate with several other genes involved in ribosomal biogenesis and nucleolar functions. These may include:

- **RPL2** (Ribosomal Protein L2)
- **RPL5** (Ribosomal Protein L5)
- **RPL11** (Ribosomal Protein L11)
- **RPL23A** (Ribosomal Protein L23A)
- **RPS14** (Ribosomal Protein S14)
  
These genes contribute to the assembly and function of ribosomes, where RPF2 plays a role in the assembly of the large ribosomal subunit.

### 2. Aging and Age-Related Diseases
Research on RPF2 in the context of aging or age-related diseases is less extensive; however, its role in ribosomal biogenesis has implications in the broader context of cellular aging. Dysfunction in ribosomal assembly has been associated with:

- **Dyskeratosis congenita**: A genetic condition affecting the skin, nails, and mucous membranes, which can occur due to disrupted ribosomal function.
- **Aging-related decline in protein synthesis**: Changes in ribosomal biogenesis and efficiency can impact aging, as the ribosome's role in synthesizing proteins is crucial for maintaining cellular functions.
- **Cancer**: RPF2's involvement in p53 signaling suggests that alterations in its function may play a role in tumorigenesis, especially since both p53 and ribosomal biogenesis are known to be implicated in cancer progression.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes distinctly associated with RPF2 interactions. However, drugs that affect ribosome biogenesis and function may influence RPF2 indirectly. Such drug classes could include:

- **Antibiotics targeting ribosomal activity**: E.g., aminoglycosides and macrolides which may indirectly impact ribosomal function.
- **Chemotherapeutic agents**: Some drugs designed to inhibit cellular proliferation, like certain kinase inhibitors, could influence pathways involving RPF2.

### 4. Pathways and Biological Processes
RPF2 is involved in several key pathways and biological processes, including:

- **Ribosome biogenesis**: Crucial for the formation of ribosomal large subunits.
- **Nucleolar function**: Facilitating the localization and assembly of 5S RNP (ribonucleoprotein) complexes in the nucleolus.
- **Protein targeting to the nucleolus**: Involved in the transport and localization of ribosomal components to the nucleolus.
- **p53 signaling pathway**: RPF2 may regulate various aspects of cell proliferation and stress responses mediated by p53.

In summary, RPF2 plays a pivotal role in ribosomal biogenesis, interacts with multiple ribosomal proteins, and could have implications related to aging and cancer through its involvement in crucial cellular pathways. However, further research may be required to fully elucidate these associations and their biological significance.