### DDX11L16 Gene Overview

**Gene Symbol:** DDX11L16

**Summary:** DDX11L16 is a gene that encodes a member of the DEAD-box helicase family, which is characterized by the presence of the conserved DEAD (aspartate-glutamate-alanine-aspartate) box motif. DEAD-box proteins are involved in various cellular processes including RNA metabolism, translation initiation, and ribosome biogenesis.

---

### 1. Associated Genes
While specific associations can vary based on studies, DDX11L16 may have functional homologs or interactors related to helicases or RNA processing. Genes of potential interest in association studies may include:

- **DDX11** (a closely related helicase gene involved in maintaining genome stability)
- **DDX17** 
- **AURKB** (Aurora kinase B, implicated in cell division)
- **XPO1** (Exportin 1, involved in nucleocytoplasmic transport)
- **RBMX** (RNA Binding Motif Protein, involved in RNA processing)

These genes may show co-expression or involvement in similar biological pathways.

---

### 2. Aging and Age-Related Diseases
There is currently limited evidence directly linking DDX11L16 with aging or age-related diseases specifically. However, given its role in RNA metabolism and genomic stability, it may contribute indirectly to cellular processes relevant to aging, such as telomere maintenance and transcriptional regulation. Mutations or dysregulation in helicase genes have been implicated in certain age-related diseases, particularly in the context of cancer, neurodegeneration, and other conditions where genomic integrity is compromised.

---

### 3. Drug Interactions
As of October 2023, there are no specific drugs or drug classes widely reported to directly target DDX11L16. However, class-wide effects of helicases have been linked to certain anti-cancer therapies, which may influence pathways in which DDX11L16 is involved. In a research context, experimental compounds that modulate helicase activity (e.g., certain ATPase inhibitors) may indirectly impact its expression or function.

---

### 4. Pathways and Biological Processes
DDX11L16 is likely involved in several biological processes, including:

- **RNA Metabolism:** Roles in RNA splicing, translation, and ribosome assembly.
- **DNA Repair and Maintenance:** Similar helicases are critical for mechanisms such as homologous recombination and the maintenance of genomic stability.
- **Cell Cycle Regulation:** Involvement in the regulation of various stages of the cell cycle.
- **Mitotic Regulation:** Implicated in processes related to chromosome segregation.

Specific pathways include:

- **RNA Transport Pathway**
- **Cell Cycle Pathway**
- **Nucleotide Excision Repair Pathway**
- **Cytoplasmic Stress Granule Assembly**

Understanding the functional implications of DDX11L16 through these pathways may provide further insight into its role in cellular physiology and potential pathological states.

---

Please note that ongoing research may add to the understanding of DDX11L16’s functions, associations, and implications in health and disease. For the most current information, consulting recent literature and databases is advisable.