### TAS2R14 Gene Overview

**Gene Symbol:** TAS2R14  
**Location:** Chromosome 12p13  
**Family:** G-protein-coupled receptors  
**Function:** Bitter taste perception and gastrointestinal chemical sensing  

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### 1. Associated Genes

The TAS2R14 gene is part of the larger cluster of taste receptor genes located on chromosome 12, known as the taste receptor gene family. Genes that are associated with TAS2R14, particularly those involved in bitter taste perception, include:

- **TAS2R4:** Another bitter taste receptor.
- **TAS2R7:** Involved in the detection of bitter compounds.
- **TAS2R43:** Also functions in bitter taste transduction.
- **GNAI2 (Guanine Nucleotide-binding Protein G(i) Subunit Alpha-2):** As part of the taste signaling pathway linked to G-protein-coupled receptors.

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### 2. Aging and Age-related Diseases

While specific research linking TAS2R14 directly with aging or age-related diseases is limited, it is known that changes in taste perception can occur with age, leading to changes in dietary preferences and nutritional intake. Dysregulation in bitter taste perception may influence the intake of certain foods or medications in older adults. Furthermore, altered expression of taste receptors, including TAS2R14, has been noted in various metabolic and gastrointestinal conditions, which may be of particular relevance in aging populations.

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### 3. Drug Interactions

Research has shown that some bitter taste receptors, including TAS2R14, may interact with various pharmaceutical compounds due to their role in bitter taste perception. There are ongoing studies to explore these interactions. While specific drugs are not definitively listed as interacting with TAS2R14, it is recognized that:

- **Bitter compounds in drugs:** Drugs that are inherently bitter may interact with TAS2R14, potentially affecting patient compliance and absorption.
- **Bitter agonists:** Compounds that mimic the action of bitter tastants may affect pathways linked to TAS2R14, particularly in therapeutic approaches targeting gastrointestinal functioning.

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### 4. Pathways and Biological Processes

TAS2R14 is involved in several pathways and biological processes, including:

- **Bitter Taste Signal Transduction:** The gene may activate phospholipase C beta-2 (PLC-beta-2) via G-protein coupling (alpha gustducin), resulting in the activation of downstream signaling pathways and leading to gustatory nerve responses.
- **Gustatory Perception:** Plays a critical role in the sensation of bitter taste, influencing food intake and preference.
- **Gastrointestinal Responses:** Response to bitter compounds may regulate gastrointestinal motility and digestive processes, contributing to nutrient absorption and gut health.
- **Cell Response to External Stimuli:** As a GPCR, TAS2R14 is involved in cellular responses to external chemical signals, influencing various physiological responses.

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### Conclusion

The TAS2R14 gene is a vital component in the gustatory system, particularly in the perception of bitterness. Its interaction with other receptor genes and potential role in age-related changes in taste perception and health present interesting avenues for further research in both basic biology and clinical medicine.