### SNORD116-12 Gene Summary

- **Gene Symbol**: SNORD116-12
- **Aliases**: Also referred to as C/D box small nucleolar RNA (snoRNA), it is part of the SNORD116 family involved in guiding the modification of rRNA and possibly involved in various regulatory functions.

### 1. Associated Genes

While specific associations can vary based on different studies, some notable genes related to SNORD116-12 include:

- **SNORD116** (the broader family of snoRNAs, of which SNORD116-12 is a member).
- **UGT2B17**: This gene has shown associations in studies involving SNORD116-related functions.
- Genes involved in imprinting, such as **IGF2** (Insulin-like Growth Factor 2), may also relate due to their genetic association with growth and development pathways.

More comprehensive databases like GeneCards and similar resources can provide insights into other genes linked through genetic, functional, or regulatory networks.

### 2. Aging or Age-Related Diseases

Research indicates that snoRNAs, including SNORD116-12, may have roles in cellular processes related to aging:

- **Epigenetics**: The gene is involved in the regulation of gene expression, alterations in which can contribute to age-related transcriptional changes.
- **Neurodegeneration**: Some studies point to snoRNAs playing roles in neurodegenerative diseases, including Alzheimer's disease, where they may impact the processing of rRNA and, consequently, the production of proteins critical for neuronal health.
  
More targeted research is necessary to fully elucidate the specific contributions of SNORD116-12 in these contexts.

### 3. Drug Interactions

Currently, there is limited information regarding specific drugs or drug classes that directly interact with SNORD116-12. Since this gene encodes snoRNA involved in the modification of ribosomal RNA rather than direct enzymatic site actions or metabolites, traditional pharmacological interactions may not be as prominent. 

However, drugs impacting RNA metabolism, such as those affecting transcription processes, could influence the gene's function indirectly. Any associations with drug classes may emerge as research evolves.

### 4. Pathways and Biological Processes

SNORD116-12 is implicated in several biological processes, including but not limited to:

- **rRNA Modification**: SNORD116-12 is critical in guiding the methylation of rRNA, influencing ribosome function and protein synthesis.
- **Regulation of Gene Expression**: It contributes to post-transcriptional regulation of various genes.
- **Imprinting and Growth Regulation**: Given its association with the imprinted region of chromosome 14, where growth-regulatory genes reside, it may have a role in processes involving growth and development.

### Conclusion

Overall, SNORD116-12 serves as an important small nucleolar RNA with potential roles in gene expression regulation and involvement in aging processes. Ongoing research into its interactions and implications will shed more light on its biological significance.