### TMEM87B Gene Summary

**Gene Symbol:** TMEM87B  
**Location:** Human Chromosome 2, Band q13  
**Function and Expression:** The TMEM87B gene encodes a transmembrane protein that has been implicated in endosome-to-trans-Golgi network (TGN) retrograde transport and may interact with HPV type 18 E6 oncogene. This protein is expressed in various tissues, notably in the brain and heart, during both fetal and adult stages.

### 1. Associated Genes
While specific associations may vary among studies, genes that have been mentioned in the literature alongside TMEM87B include:
- **TMEM87A:** A close homolog of TMEM87B, which is likely related in function.
- **RAB GTPase Family Genes (e.g., RAB7):** These are involved in vesicular transport, potentially linking to TMEM87B’s function in retrograde transport.
- **Genes involved in congenital heart defects (e.g., HAND1, NKX2-5):** While not directly associated, alterations in TMEM87B may have implications for pathways involving these genes.

### 2. Aging and Age-Related Diseases
Currently, specific data directly linking TMEM87B to aging or age-related diseases is limited. However, due to its role in cellular transport mechanisms, any disruption may potentially impact cellular homeostasis and contribute to diseases of aging or degenerative processes. The involvement in congenital heart defects might indirectly suggest a role in heart aging or related pathophysiology; conditions affecting the heart are prevalent in aging populations.

### 3. Drug Interactions
As of now, there are no well-documented drug interactions specifically associated with TMEM87B in the major databases. However, given its role in cellular trafficking and potentially in oncogenesis due to HPV interaction, it may be of interest in studies involving antineoplastic therapies or drugs targeting viral oncogenes.

### 4. Pathways and Biological Processes
TMEM87B is involved in several biological processes, including:
- **Endosomal Transport:** Facilitating the retrograde transport from endosomes to the trans-Golgi network, which is critical for maintaining cellular protein sorting and recycling mechanisms.
- **Cellular Signaling:** As a potential interacting partner with oncogenic proteins like HPV E6, it may also partake in signaling pathways related to cell proliferation and differentiation.
- **Developmental Processes:** Its expression in fetal tissues suggests participation in developmental biology, particularly concerning organogenesis and heart development.

An important pathway that TMEM87B may be associated with is the **Vesicle-mediated Transport Pathway**, influencing both endocytosis and Golgi apparatus functions.

### Conclusion
TMEM87B serves multiple roles within cell biology, particularly involving retrograde transport and potentially in oncogenic processes. Ongoing research will likely shed more light on its comprehensive interactions and implications in various diseases, particularly in the context of cardiovascular health and potentially in relation to aging processes.