### PPP2R5A Gene Overview
**Gene Symbol**: PPP2R5A  
**Functional Role**: The PPP2R5A gene encodes a member of the B regulatory subunit of protein phosphatase 2A (PP2A), known for its crucial role in the negative regulation of cell growth and division by dephosphorylating various substrates. This particular isoform belongs to the B56 subfamily, which is involved in modulating substrate specificity, catalytic activity, and localization of the PP2A holoenzyme.

### 1. Associated Genes
While the summaries provided do not mention specific genes directly associated with PPP2R5A, it is known to interact with several other genes/proteins involved in cellular signaling and regulation, including:
- **PPP2CA**: Encodes the catalytic subunit of PP2A.
- **PPP2R1A**: Encodes a regulatory subunit that forms part of the PP2A complex.
- **AKT1**: Encodes a protein kinase involved in signaling pathways regulated by PP2A.

PPP2R5A may also interact with other proteins involved in critical signaling pathways, such as those linked to tumorigenesis and cell cycle regulation.

### 2. Aging and Age-Related Diseases
Research suggests that dysregulation of PP2A activity, including activity modulated by PPP2R5A, is implicated in several age-related diseases:
- **Cancer**: Altered expression or mutation of PPP2R5A has been observed in various cancers, where it may influence tumor growth and resistance to therapy.
- **Neurodegeneration**: The involvement of PP2A in regulating tau phosphorylation implies a potential link to Alzheimer’s disease and other tauopathies. Changes in PPP2R5A expression could influence tau pathology.
- **Cardiovascular Diseases**: Alterations in the function of PP2A, due to dysregulation of its regulatory subunits like PPP2R5A, have also been linked to age-associated cardiovascular diseases.

### 3. Drug Interactions
The PPP2R5A gene does not have direct pharmacological agents targeting it specifically; however, because it is part of the PP2A family, drugs that affect PP2A function could indirectly influence the expression and activity of PPP2R5A. These may include:
- **Okadaic Acid**: A potent inhibitor of protein phosphatases, including PP2A.
- **Fostamatinib**: A drug that can modulate signals downstream of the PDGF signaling pathway, which may involve PP2A.
- **Various Chemotherapeutic Agents**: Some chemotherapeutic strategies aim to restore or enhance PP2A activity, which implicates regulatory subunits like PPP2R5A.

### 4. Pathways and Biological Processes
PPP2R5A is involved in several critical cellular pathways and biological processes, including:
- **Cell Cycle Regulation**: PP2A plays a significant role in controlling various checkpoints and progression through the cell cycle.
- **Signal Transduction**: Involvement in pathways such as the MAPK/ERK pathway and AKT signaling pathway.
- **Cellular Stress Response**: Participates in the cellular mechanisms that respond to stress and damage.
- **Apoptosis**: Modulates pathways related to programmed cell death, which is crucial for maintaining tissue homeostasis.

### Conclusion
In summary, the PPP2R5A gene encodes a regulatory subunit of PP2A, essential for controlling cell growth and division. Its dysregulation is associated with aging and various diseases, particularly cancer and neurodegenerative conditions. Therefore, understanding PPP2R5A further may offer insights into potential therapeutic strategies in these fields.