### Overview of the TP73-AS3 Gene

**Gene Symbol:** TP73-AS3  
**Description:** TP73-AS3 (Tumor Protein p73 Antisense RNA 3) is an antisense non-coding RNA associated with the TP73 gene, which encodes a transcription factor belonging to the p53 family. TP73 is involved in various cellular processes, including apoptosis and cell cycle regulation, and is thought to play a role in tumor suppression.

### 1. Associated Genes
While the NCBI and UniProt summaries may not explicitly list them, TP73-AS3 can be associated with the following genes:

- **TP73**: As the primary gene it regulates, its expression and function are closely linked.
- **TP53**: Although not directly regulated by TP73-AS3, TP53 has functional interactions and overlaps in pathways with TP73, correlating with tumor suppression mechanisms.

### 2. Aging and Age-Related Diseases
Research indicates that the expression of TP73-AS3 may be involved in:

- **Cancer**: Altered expression patterns of TP73 and its antisense RNA can influence tumorigenesis. Variations in TP73-AS3 expression have been linked to the development and progression of several age-related malignancies.
- **Neurodegenerative Diseases**: Studies have indicated that TP73 and its regulatory networks may influence neurodegenerative processes, linking them to brain aging.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly target TP73-AS3 are not well established in scientific literature. However, given its involvement in tumorigenesis, it may be indirectly affected by:

- **Chemotherapeutic agents**: Drugs aimed at targeting cancers might modulate TP73 and indirectly influence TP73-AS3 expression.
- **Targeted therapies**: Such as those involving the p53 family or signaling pathways affected by p53/TP73 activities.

### 4. Pathways and Biological Processes
TP73-AS3 is involved in:

- **Regulation of Apoptosis**: TP73, as a transcription factor, influences genes involved in programmed cell death, which can also involve regulatory non-coding RNAs like TP73-AS3.
- **Cell Cycle Regulation**: As a component of the regulatory network, TP73-AS3 can affect cell cycle checkpoints through TP73-mediated pathways.
- **Response to DNA Damage**: TP73 is implicated in pathways responding to DNA damage, and TP73-AS3 could play a role in modulating the response.

### Conclusion
TP73-AS3 serves as an important regulatory element associated with the TP73 gene, with implications in aging and age-related diseases, particularly through its roles in cancer biology. The interaction with other genes, its involvement in specific biological pathways, and possible indirect drug interactions warrant further investigation for therapeutic applications in oncology and gerontology.