### OR52M1 Gene Overview

**Gene Symbol**: OR52M1  
**Function**: The OR52M1 gene encodes an olfactory receptor that interacts with odorant molecules in the nasal epithelium, initiating a neuronal response that leads to the perception of smell. As a member of the G-protein-coupled receptors (GPCR) family, these proteins exhibit a characteristic 7-transmembrane domain structure. The olfactory receptor gene family is one of the largest in the human genome, and the naming system for these genes is specific to individual species, making it distinct from those in other organisms.

### 1. Associated Genes

While the specific gene associations for OR52M1 are not documented in the provided summaries, olfactory receptors often work in coordinated networks. Other olfactory receptor genes such as **OR52L1**, **OR5L2**, and other members of the OR gene family may share pathways or functional interactions, given their roles in smell perception.

### 2. Aging and Age-Related Diseases

Research connecting specific olfactory receptors, including OR52M1, to aging or age-related diseases is still limited. However, the olfactory system is known to undergo functional decline with age, potentially leading to a reduced sense of smell (hyposmia) which can be one of the early signs of neurodegenerative diseases such as Alzheimer's disease. Changes in olfactory receptor expression or function have been observed in various age-related conditions, although specific associations with OR52M1 may require further exploration through targeted studies.

### 3. Drug Interaction

As of now, there are no widely documented specific drugs or drug classes that interact directly with the OR52M1 gene product. However, olfactory receptors can potentially influence the pharmacodynamics of certain CNS-active drugs, particularly those that might modify sensory perceptions. Studies investigating the broader implications of olfactory receptor activity in pharmacology may reveal indirect interactions.

### 4. Pathways and Biological Processes

OR52M1 is primarily involved in the following pathways and processes:

- **Olfactory Signaling Pathway**: It plays a critical role in the detection and transduction of odorant signals, leading to a sensory perception of smell.
- **G-protein Coupled Receptor (GPCR) Signaling**: As a GPCR, it participates in signal transduction pathways that link odorant molecule recognition to neuronal response.
- **Sensory Perception of Smell**: Engaged in the broader biological process of sensory perception, particularly regarding olfactory cues.

In summary, the OR52M1 gene is integral to olfactory function, playing a role in how organisms perceive and react to their environment. Further research is necessary to delineate its specific interactions and implications in health and disease, particularly concerning aging and pharmacology.