### Overview of the OFD1 Gene

**Gene Symbol:** OFD1  
**Location:** X chromosome (humans), X chromosome (mouse, not subject to X inactivation)  
**Associated Syndromes:** Oral-facial-digital syndrome type I, Simpson-Golabi-Behmel syndrome type 2  

**Function:** OFD1 encodes a centrosomal protein involved in the biogenesis of cilia, regulating cilium length and cellular signaling pathways, including Wnt signaling and left-right axis specification. It plays a critical role in autophagy, particularly in the removal of centriolar satellites during ciliogenesis.

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### 1. Associated Genes
Beyond the genes typically mentioned in the context of the OFD1 gene, it has been associated with:

- **IFT88:** Involved in intraflagellar transport and ciliary assembly.
- **CEP164:** A centriole-associated protein crucial for ciliary function.

**Pseudogenes:** Various pseudogenes have been identified, particularly on the Y chromosome (up to fifteen) and one on chromosome 5.

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### 2. Age-Related Details
While the primary literature does not specifically tie the OFD1 gene to aging directly, there are a few potential associations to consider:

- **Ciliary Dysfunction and Aging:** Given that OFD1 is involved in cilium biogenesis and function, and that ciliary dysfunction has been implicated in various aging-related disorders (e.g., kidney disease, neurodegenerative disorders), mutations in OFD1 might indirectly contribute to age-related pathology through chronic ciliary impairment.
- **Developmental Disorders:** As OFD1 is associated with developmental syndromes, understanding its role could shed light on how disruptions might lead to cellular aging or senescence, particularly in affected organ systems.

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### 3. Drug Interactions
As of the latest knowledge, there are no specific drugs or drug classes universally recognized to interact directly with OFD1. However, based on its roles in signaling pathways, potential interactions might include:

- **Wnt Signaling Modulators:** Drugs that enhance or inhibit Wnt signaling could theoretically influence the developmental effects mediated by OFD1.

**Research Interest:** There might be an emerging interest in investigating whether small molecule modulators impacting ciliary pathways could bear relevance in conditions arising from OFD1 mutations.

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### 4. Pathways and Biological Processes
OFD1 is involved in several key biological processes, including:

- **Ciliogenesis:** Essential for the formation and maintenance of primary cilia.
- **Centrosome Organization:** Plays a role in the structure and length regulation of centrioles.
- **Wnt Signaling Pathway:** Involved in the Wnt signaling cascade, essential for cell communication and development.
- **Autophagy:** Plays a part in autophagic processes specific to ciliary regulation.
- **Left-Right Axis Specification:** Critical for proper embryonic development.

Inhibition or mutations affecting these pathways could result in substantial developmental issues or contribute to formed syndromes.

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In summary, the OFD1 gene is pivotal in the proper function of centrioles and cilia, with significant implications for developmental processes and potential links to age-related impairments. Further exploration of drug interactions and broader associations with other genes may enhance understanding of its role in health and disease.