### PPP1R35 Gene Overview

**Gene Symbol:** PPP1R35

**Summary:** The PPP1R35 gene encodes a protein involved in the regulation of phosphatase activity, particularly linked to centriole duplication and elongation, as well as playing roles in primary cilia assembly. It is predicted to have phosphatase binding activity and function as a protein phosphatase inhibitor.

### 1. Associated Genes

PPP1R35 may interact with several other genes and proteins involved in similar cellular processes, including but not limited to:
- **RTTN (RING Finger and TBC Domain Containing 1):** As mentioned, this gene is directly associated with the centriole elongation function of PPP1R35.
- **CEP proteins (Centrosomal proteins):** Involved in centriole and cilia structure and function.
- **CCDC67 (Coiled-Coil Domain Containing 67):** Related to centriole and cilia function.
- **KIF3A/KIF3B:** Motor proteins involved in the transport of ciliary components, which possibly interacts through the regulatory networks.

### 2. Aging and Age-related Diseases

While specific studies directly linking PPP1R35 to aging or age-related diseases are limited, its involvement in centriole duplication and cilia assembly makes it a potential candidate for roles in:
- **Cellular senescence:** Disruption in centriole and cilia function is linked to cellular aging processes.
- **Ciliopathies:** Diseases caused by dysfunctional cilia, often presenting in mid to late life.
- Possible contributions to neurodegenerative diseases or developmental disorders where cilia play important roles.

### 3. Drug Interactions

Currently, specific drugs or drug classes directly targeting PPP1R35 are not prominently documented in existing literature. However, given its role in the regulation of phosphatase activity, indirect implications could exist:
- **Phosphatase inhibitors:** Some broader classes of drugs designed to target protein phosphatases may inadvertently affect PPP1R35 activity.

### 4. Pathways and Biological Processes

PPP1R35 is implicated in several biological pathways and processes:
- **Centriole duplication pathway:** Specifically involved in the recruitment of proteins essential for centriole elongation.
- **Cilia assembly:** Plays a role in organizing proteins required for the formation of primary cilia and potentially impacts signaling pathways associated with ciliary function.
- **Negative regulation of phosphatase activity:** Suggests involvement in various cellular signaling pathways where phosphatases play crucial regulatory roles.

In summary, while there is a foundational understanding of the PPP1R35 gene and its roles in cellular processes, further studies would elucidate its connections with specific aging mechanisms, potential drug interactions, and detailed regulatory pathways it may affect.