### RNU105B Gene Overview

**Gene Symbol:** RNU105B  
**Gene Type:** Small nucleolar RNA (snoRNA)  
**Location:** This gene is located within the nucleolus of cells where it is primarily involved in the modification and processing of ribosomal RNA (rRNA).

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### 1. Associated Genes
The RNU105B gene may interact with various other genes involved in ribosomal RNA processing and modification. While the specific associated genes may not be detailed in the summaries you referenced, snoRNAs like RNU105B typically function alongside:

- **FBL** (Fibrillarin): A key component in the formation of the nucleolus and involved in rRNA modification.
- **NOP56** and **NOP58**: These are nucleolar proteins that work with snoRNAs in the assembly and modification of snoRNP complexes.
- **NPM1** (Nucleophosmin): May also interact as it is involved in ribosome biogenesis.

Further studies may identify additional genes and their relationships that are either functionally linked or co-expressed with RNU105B.

### 2. Aging and Age-Related Diseases
Data on RNU105B directly associating with aging or age-related diseases may be limited, but alterations in snoRNA expression have been linked to various cellular processes that are often disrupted in aging. For instance:

- **Regulation of Ribosome Biogenesis:** Changes in ribosome production can impact cellular function and contribute to age-related decline in tissue homeostasis.
- **Cellular Stress Responses:** Dysregulations in snoRNA function, including RNU105B, might affect how cells respond to stressors, potentially compounding age-related damage.
- **Cancer:** Some studies have shown altered expression of snoRNAs in different cancers, suggesting a potential link between snoRNA expression and tumorigenesis, an area of interest in aging research.

While RNU105B has not been specifically mentioned in major aging studies, snoRNAs in general have emerging roles in biology of aging.

### 3. Drug Interactions
Currently, there is no direct evidence pointing toward specific drugs or drug classes that interact with RNU105B. However, the general classes of compounds that may have indirect effects include:

- **Antimetabolites:** These include drugs that inhibit ribosome biogenesis or modify RNA processes, thus potentially impacting the function of snoRNAs, including RNU105B.
- **Targeted therapies in cancer:** Since snoRNAs can influence tumorigenesis, drugs targeting pathways associated with cell proliferation might indirectly relate to the functions of RNU105B.

Specific interaction studies would be required to delineate precise connections.

### 4. Pathways and Biological Processes
RNU105B is primarily involved in the following biological processes:

- **Ribosomal RNA Maturation:** Participation in the modification of precursor rRNA, facilitating the production of mature rRNA molecules essential for ribosome assembly.
- **Nuclear RNA Processing:** Role in the processing of snoRNA and other non-coding RNAs.
- **Nucleolar Organization:** Involvement in maintaining nucleolar integrity and function, crucial for cellular metabolism and stress response.

Given its nature as a small nucleolar RNA, RNU105B is implicated primarily in the fundamental processes of ribosome biogenesis, contributing to the essential function of protein synthesis in all cellular contexts.

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This profile of RNU105B synthesizes known information and should be updated as new discoveries are made in the field of genetics and molecular biology.