### Gene Overview: SNORD115-15

**Gene Symbol**: SNORD115-15

SNORD115-15 is a small nucleolar RNA (snoRNA) gene located within the introns of the **NCR3 (Natural Cytotoxicity Trigger) gene** on chromosome 14. It belongs to the C/D box snoRNA family, which is primarily involved in guiding the methylation of rRNA and other RNAs.

### 1. Associated Genes

Apart from the NCR3 gene, the SNORD115 gene family, including SNORD115-15, is associated with several other snoRNAs within its genomic locus:
- **SNORD115-1 to SNORD115-14**: These include other members of the SNORD115 family, which may have similar functions in regulating RNA modification processes.
- Additionally, certain studies have linked the SNORD115 loci to the **SMN1 and SMN2** genes concerning spinal muscular atrophy (SMA) and gene expression regulation.

### 2. Aging and Age-Related Diseases

While specific associations of SNORD115-15 with aging or age-related diseases are not extensively documented, certain general insights can be drawn:
- **RNA Modification**: The methylation processes involving snoRNAs, like SNORD115-15, have been implicated in cellular processes that can influence cellular senescence and aging.
- Research has suggested that alterations in snoRNA expression could be related to age-related neurological disorders, though direct links to SNORD115-15 are still emerging.
- Anecdotal evidence ties snoRNA dysregulation to neurodegenerative diseases, given the crucial role of rRNA modifications in maintaining cellular function.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes directly associated with SNORD115-15 identified in the literature. However, general classes of compounds that might indirectly influence snoRNA activity include:
- **RNA-modifying agents**: Such as small molecules that enhance or inhibit methyltransferase activities.
- **Antisense oligonucleotides (ASOs)**: These have been shown to target specific RNA sequences and could potentially influence the levels of snoRNAs, including SNORD115-15.

### 4. Pathways and Biological Processes

SNORD115-15 is primarily involved in the following biological processes:
- **Ribosome Biogenesis**: As part of the snoRNA family, SNORD115-15 is crucial for the processing and modification of pre-ribosomal RNA, facilitating effective ribosome assembly.
- **RNA Methylation**: It acts as a guide for the methylation of specific rRNA nucleotides, thus contributing to the proper functioning of the ribosome and protein synthesis.
- **Spliceosome Assembly**: Some studies suggest that snoRNAs may have roles beyond ribosome biogenesis, potentially in spliceosomal RNA modifications.

### Summary

SNORD115-15 is a small nucleolar RNA that plays an important role in ribosome biogenesis through rRNA modification. While specific associations with aging and drug interactions are limited, it may influence broader biological processes integral to cellular function and health. Further research is required to elucidate its precise roles in age-related diseases and potential therapeutic implications.