### ARHGEF26-AS1 Gene Overview

**Gene Symbol:** ARHGEF26-AS1  
**Function:** ARHGEF26-AS1 is classified as an antisense RNA, which is a non-coding RNA that may play a role in regulating the expression of nearby genes, particularly ARHGEF26. Non-coding RNAs are involved in various cellular processes, including gene regulation, epigenetics, and chromatin remodeling.

### Associated Genes
ARHGEF26-AS1 has been closely linked to the following genes:
- **ARHGEF26 (Rho guanine nucleotide exchange factor 26):** This gene encodes a protein that activates Rho GTPases, which play a crucial role in various cellular functions such as cytoskeletal dynamics, cell migration, and cellular signaling pathways.

Additional genes associated through pathways or functional networks may include:
- **RHOA (Ras homolog family member A):** A member of the Rho family that interacts with proteins regulated by ARHGEF26.
- **Rac1:** Involved in leading to cell motility, adhesion, and proliferation; pathways involving Rho GTPases often include Rac1.

### Age-Related Associations
While specific studies directly linking ARHGEF26-AS1 with aging are limited, there is evidence to suggest that Rho GTPases (that ARHGEF26 influences) are involved in processes related to aging and age-related diseases including:
- **Cellular senescence:** Changes in Rho GTPase signaling can influence pathways associated with cellular senescence.
- **Cancer:** Altered expression of GEFs, including ARHGEF26, can contribute to tumorigenesis and cancer progression, which are often associated with aging.
- **Neurodegenerative diseases:** Changes in cytoskeletal dynamics and signaling pathways influenced by Rho GTPase activity can play a role in neurodegeneration.

### Drug Interactions
As of the latest information available until October 2023, specific drugs that directly interact with the ARHGEF26-AS1 gene product are not widely documented. However, since ARHGEF26 is related to Rho GTPase signaling, drugs that influence Rho GTPase activity could indirectly relate to the functions of ARHGEF26-AS1. Some classes of such drugs may include:
- **Rho kinase inhibitors:** These agents, by modulating the activity of Rho-related proteins, could potentially influence processes in which ARHGEF26-AS1 and its associated pathways are involved.

### Pathways and Biological Processes
ARHGEF26-AS1 is involved in several biological processes through its association with ARHGEF26:
- **Rho GTPase signaling:** It is involved in the activation of Rho GTPases, affecting cellular architecture and signaling pathways.
- **Cell migration and adhesion:** These processes are critical in development as well as in response to injury and in cancer metastasis.
- **Regulation of actin cytoskeleton:** Through the action of Rho GTPases, ARHGEF26-ARHGEF26-AS1 may play a role in modulating the cytoskeleton's organization.

### Summary
In summary, ARHGEF26-AS1 is an antisense RNA that regulates ARHGEF26, which subsequently influences Rho GTPase signaling pathways with implications in cellular processes, possibly related to aging and various diseases. While direct drug interactions and specific drug classes are not well-established, this gene is integrated into broader signaling networks relevant for cell dynamics and health. Continued research into ARHGEF26-AS1 might illuminate more precise roles in age-related processes and potential therapeutic interactions.