### Gene Summary: RNA5SP353

**Gene Symbol**: RNA5SP353  
**Gene Type**: Non-coding RNA  
**Location**: Human genome on chromosome 5  

### 1. Associated Genes
RNA5SP353 is a small nucleolar RNA (snoRNA) involved in the modification of other RNAs, particularly within the nucleolus. While specific associated genes are not commonly highlighted in general summaries, snoRNAs often work with ribosomal RNA (rRNA) genes and can interact with genes involved in cell cycle regulation and RNA modification processes. Other snoRNAs and genes involved in ribosome biogenesis, such as *NOP58*, *BOX C/D snoRNP components*, and various rRNA genes, may be functionally associated.

### 2. Aging or Age-Related Disease Associations
The literature specifically linking the RNA5SP353 gene to aging or age-related diseases is limited. However, disruptions in snoRNA function have been implicated in several age-related pathologies, including various cancers and neurodegenerative diseases. Hence, while RNA5SP353 may not have direct associations documented in public databases, its general role in ribosome biogenesis and RNA modification processes suggests a potential indirect role in aging and age-associated diseases.

### 3. Drug Interactions
As RNA5SP353 is a non-coding RNA, it is generally not a direct target for drugs. However, drugs that alter RNA metabolism or spliceosomal function could theoretically impact snoRNA activity. Classes of drugs that might affect RNA processing and modification pathways include:

- **Antiviral agents** - Some can interfere with host RNA processing.
- **Chemotherapeutic agents** - Drugs that induce stress responses in cells may indirectly affect snoRNA function due to their involvement in the ribosome's biogenesis and assembly.

### 4. Pathways and Biological Processes
RNA5SP353 participates in various biological processes, primarily related to:

- **Ribosomal RNA (rRNA) modification**: It plays a role in the post-transcriptional modification of rRNA, a function supported by its classification as a snoRNA. These modifications are crucial for the maturation of rRNA and overall ribosome functionality.
- **Nucleolar organization and function**: RNA5SP353 is part of the nucleolus, which is essential for processing rRNA and assembling ribosomal subunits.
- **Regulation of gene expression**: As with other snoRNAs, it may also be involved indirectly in regulating the expression of nearby genes through RNA processing or modification.

### Conclusion
RNA5SP353 is a small nucleolar RNA with roles primarily in the modification and processing of rRNA, influencing ribosome biogenesis. While it does not have explicit connections to aging or known drug interactions, its functions might implicate it in broader cellular contexts and molecular pathways that relate to cell function, stress responses, and potentially disease development. Further research could provide more clarity on its specific roles and associations.