### RNA5SP280 Gene Overview

**Gene Symbol:** RNA5SP280  
**NCBI Gene ID:** 100201478  
**UniProt ID:** Not provided, but related identifiers can help identify functional roles.

RNA5SP280 is a small nucleolar RNA (snoRNA) gene that belongs to the class of C/D box snoRNAs. These types of snoRNAs are primarily involved in the modification and processing of ribosomal RNA (rRNA).

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### 1. Associated Genes

While the RNA5SP280 gene specifically is not widely known to be linked with other genes in a functional or regulatory pathway due to its classification as a snoRNA, similar snoRNA genes or related rRNA modification genes may be considered:

- **Other snoRNAs**: snoRNAs such as those in the C/D box family (e.g., SNORD52, SNORD61) may collaborate with or have similar expression patterns.
- **rRNA modification genes**: Genes involved in the biogenesis of rRNAs, such as those coding for methyltransferases or other RNA processing enzymes, could also be functionally related.

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### 2. Aging and Age-Related Diseases

Currently, specific literature directly associating RNA5SP280 with aging or age-related diseases is limited. However, several studies have linked disturbances in the regulation and function of snoRNAs to:

- **Age-Related Degeneration**: Disruptions in small RNA profiles, including snoRNAs, have been observed in age-related conditions such as neurodegeneration, indicating a potential indirect association.
- **Cellular Aging**: Changes in rRNA modification processes, where snoRNAs play a significant role, may influence cellular aging processes and senescence by affecting protein synthesis and cellular stress responses.

Greater research into the specific roles of snoRNAs in aging is needed to establish concrete connections with RNA5SP280.

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### 3. Drug Interactions

There are no specific drugs or drug classes known to directly interact with RNA5SP280. However, because snoRNAs are involved in rRNA processing, any drugs that affect ribosomal function, protein synthesis, or cellular RNA activity may indirectly influence the functions of snoRNAs. Some noteworthy categories might include:

- **Ribosome-targeting antibiotics**: Such as aminoglycosides (e.g., gentamicin) and macrolides (e.g., erythromycin) can affect ribosomal activity and may also influence snoRNA functionality indirectly.

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### 4. Pathways and Biological Processes

RNA5SP280, as a snoRNA, is primarily involved in the following pathways and biological processes:

- **Ribosome Biogenesis**: RNA5SP280 contributes to the modification of rRNA, which is essential for the assembly and function of ribosomes.
- **RNA Modification**: It is specifically involved in the 2'-O-methylation of rRNA, helping regulate ribosomal function and stability.
- **Gene Expression Regulation**: SnoRNAs have implications in gene expression through their effects on ribosomal proteins and other RNA species.
- **Non-coding RNA Pathway**: RNA5SP280 is part of the broader non-coding RNA processing pathways, crucial for cellular RNA metabolism.

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### Conclusion

RNA5SP280 is a snoRNA that plays an important role in the modification of rRNA and, consequently, the ribosome's structure and function. While specific interactions with drugs and definitive associations with aging or disease remain under-explored, its fundamental role in ribosome biogenesis highlights its importance in cellular biology. Ongoing research may elucidate further details about its function and clinical relevance.