### CCDC54 Gene Overview

**Gene Symbol**: CCDC54  
**Description**: The CCDC54 gene (Coiled-Coil Domain Containing 54) encodes a protein that is part of a large family of coiled-coil proteins, which generally are involved in a variety of cellular processes, including structural integrity, regulation of cellular signaling, and protein-protein interactions.

### 1. Associated Genes

While specific associations may vary, CCDC54 has been linked to the following genes through functional networks and co-expression analysis:

- **CTNNB1**: Catenin (Cadherin-Associated Protein), Beta 1
- **SPECC1**: Sperm Specific Antigen 1
- **PKP1**: Plakophilin 1
- **DLGAP1**: DLG Associated Protein 1

These associations are based on functional annotations and co-expression studies and indicate potential pathways in which CCDC54 may participate.

### 2. Aging and Age-Related Diseases

Current literature suggests that changes in the expression levels of the CCDC54 gene could play a role in cellular aging processes. While specific age-related diseases directly attributed to CCDC54 are not well-defined, coiled-coil domain proteins are often implicated in cellular integrity and disease states that are a hallmark of aging, such as:

- **Neurodegenerative diseases**: Even though direct evidence is limited, alterations in protein interactions due to aging can influence neurodegeneration.
- **Cancer**: There are some emerging studies indicating that coiled-coil proteins like CCDC54 might be involved in cancer cell behavior and angiogenesis, implicating potential age-related risks.

Further studies are necessary to clarify the exact role of CCDC54 in aging and related diseases.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes widely recognized to interact directly with CCDC54. However, as with many genes involved in signaling and cellular processes, the protein encoded by CCDC54 may indirectly affect the efficacy of certain therapeutic agents, especially those targeting pathways connected to cell adhesion, structural integrity, or signaling pathways.

### 4. Pathways and Biological Processes

CCDC54 is implicated in various biological pathways and processes, including:

- **Cellular Adhesion**: The coiled-coil domain of CCDC54 may play a functional role in cell-cell adhesion mechanisms, necessary for tissue integrity.
- **Signal Transduction**: Involvement in pathways that modulate intracellular signaling cascades.
- **Cell Cycle Regulation**: Potential roles in ensuring proper division and maintenance of cellular integrity during cell division.
- **Developmental Processes**: Coiled-coil proteins like CCDC54 may play a role in various developmental pathways, influencing morphogenesis and tissue differentiation.

### Conclusion

CCDC54 is a coiled-coil domain-containing protein with potential implications in various biological processes, though its precise functions and associations with age-related diseases and drug interactions remain areas for further exploration. The ongoing research may uncover more about its roles in cellular dynamics and its potential therapeutic targets.