### SH2D3C Gene Overview

**Gene Symbol:** SH2D3C  
**Function:** The SH2D3C gene encodes an adaptor protein that plays a critical role in cell signaling pathways related to cell adhesion, migration, and the immune response. It contains a Src homology 2 (SH2) domain and a guanine nucleotide exchange factor-like domain, which facilitate interactions with other proteins involved in these processes.

### 1. Associated Genes
The SH2D3C gene has several known interactions with other genes, some of which may include:

- **BCAR1** (Breast cancer anti-estrogen resistance 1): Involved in integrin-mediated signaling pathways.
- **CRK** (Crk proto-oncogene): Functions in cell signaling and is associated with CRK-associated substrate (p130Cas).
- **RAPGEF1** (Rap guanine nucleotide exchange factor 1): Interacts with BCAR1 in the signaling pathway and plays a role in small GTPase activation.
- **NEDD9/CASL** (Neural precursor cell expressed, developmentally downregulated 9): Involved in pathways important for cell migration and signaling.
- **CXCL13** (C-X-C motif chemokine ligand 13): Participates in B-cell chemotaxis and immune response mechanisms.

Additionally, interactions have been noted with proteins involved in neuronal development, highlighting the role of SH2D3C in various cellular contexts.

### 2. Aging and Age-Related Diseases
Currently, there are no direct studies linking SH2D3C specifically to aging or age-related diseases based on the available literature up to October 2023. However, given its involvement in cell migration and immune response, it may play an indirect role in age-related immunosenescence or diseases requiring effective cell signaling and maintenance of tissue integrity. Dysregulation of its function may correlate with age-related conditions, particularly those involving immune function, such as chronic inflammatory diseases or cancer.

### 3. Interacting Drugs and Drug Classes
As of October 2023, there are no specific drugs or drug classes documented to interact directly with SH2D3C. However, because of its role in cell signaling and migration, it influences pathways that could be targeted by various cancer therapies or immunomodulatory drugs that affect B-cell activation and functioning.

### 4. Pathways and Biological Processes Involved
The biological processes and pathways with which SH2D3C is associated include but are not limited to:

- **Cell Adhesion:** SH2D3C mediates integrin signaling pathways critical for cellular adhesion and migration.
- **Immune Response:** Play a significant role in B-cell development and function, particularly in the splenic marginal zone, crucial for the proper functioning of the immune system.
- **Cell Migration:** Involvement in promoting migration through the extracellular matrix, essential for processes such as tissue repair and development.
- **Neuronal Development:** Associated with the migration of olfactory sensory neurons during brain development, highlighting its role in the nervous system development.
- **BCAR1-CRK-RAPGEF1 Signaling Pathway:** This pathway is relevant in the context of cancer biology, specifically in relation to invasiveness and metastasis.

In summary, the SH2D3C gene is a multifunctional protein implicated in several biological processes, notably in cell signaling, adhesion, and immune function, reflecting its importance in both normal physiology and potential pathological states.