### SHANK2-AS2 Gene Overview

**Gene Symbol:** SHANK2-AS2  
**Location:** The SHANK2-AS2 gene is a long non-coding RNA (lncRNA) located at the chromosome 11q13.1 locus.

### Additional Information and Related Genes
1. **Associated Genes:**
   - **SHANK2**: The SHANK2-AS2 is an antisense lncRNA associated with the SHANK2 gene, which is crucial for synaptic function in neurons.
   - **PSD-95 (DLG4)**: While not directly linked to SHANK2-AS2, it is involved in similar protein interactions and synaptic processes.
   - **Other SHANK family members**: Such as SHANK1 and SHANK3, which are also critical for synaptic integrity and signaling.

### Aging and Age-Related Diseases
2. **Known Details Related to Aging or Age-Related Diseases:**
   - The SHANK2 gene, which SHANK2-AS2 regulates, has been implicated in neurological disorders and cognitive decline, which notably increase with aging.
   - Alterations in SHANK2 levels or function have been associated with neurodevelopmental disorders and some forms of dementia, such as Alzheimer's disease.
   - Studies suggest that lncRNAs, like SHANK2-AS2, can influence processes like inflammation and synaptic plasticity, which are vital in aging and age-related neurodegeneration.

### Drug Interactions
3. **Known Drug or Drug Classes:**
   - As of the latest updates, there are no direct drugs listed specifically targeting the SHANK2-AS2 gene. However, drugs affecting synaptic plasticity and neurotrophic factors could potentially influence SHANK2 expression indirectly.
   - Drug classes related to psychiatric and neurological treatments may involve pathways that are influenced by SHANK2 and its associated lncRNAs.

### Pathways and Biological Processes
4. **Pathways and Biological Processes:**
   - **Synaptic signaling**: SHANK2-AS2 plays a regulatory role in the expression of proteins related to synaptic structure and function.
   - **Neurological development**: It is implicated in processes of neuronal maturation and synaptogenesis.
   - **Neurotransmitter signaling pathways**: This gene influences pathways that modulate synaptic transmission and signal processing within the nervous system.
   - **Regulation of Gene Expression**: Through modulation of chromatin structure or recruitment of transcriptional machinery, SHANK2-AS2 impacts the expression of genes involved in neuronal functions.

### Conclusion
SHANK2-AS2, through its association with the SHANK2 gene and involvement in various neurobiological processes, plays a critical role in neuronal health, linked to aging and neurodegeneration. Its precise mechanisms, particularly regarding therapeutic implications, remain an area of ongoing research.