### CD163L1 Gene Overview

**Gene Symbol**: CD163L1  
**NCBI Gene ID**: 51612  
**UniProt Accession**: Q9BTC5

The CD163L1 gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily, which comprises proteins primarily associated with the immune system. CD163L1 consists of multiple SRCR domains, a transmembrane domain, and a cytoplasmic domain, facilitating its role in various immune responses through protein-protein interactions and ligand binding.

### Additional Information

1. **Associated Genes**: 
   - **CD163**: A closely related gene that encodes a protein known as a scavenger receptor, which is primarily expressed in monocytes and macrophages and involved in the response to inflammation.
   - **CD68**: Another marker for macrophages, which helps in the endocytic process and is often studied in conjunction with CD163L1 in immune response contexts.
   - **SRCRB**: A family member that shares the scavenger receptor cysteine-rich motif and may have functional similarities to CD163L1.
   - **CLEC7A** (Dectin-1): May be coordinated in immune signaling and pathogen recognition alongside scavenger receptors.

2. **Aging or Age-related Diseases**:
   - Scavenger receptors like CD163L1 have roles in inflammation and immune response, processes that are linked with aging and age-related diseases, including atherosclerosis, neurodegeneration, and chronic inflammatory conditions.
   - The expression patterns of CD163L1 may change with age, potentially impacting macrophage function and the body's ability to respond to pathogens or clear cellular debris, contributing to the aging phenotype.

3. **Drugs or Drug Classes**:
   - Currently, there are no specific drugs or drug classes that have been directly associated with CD163L1 targeting in clinical use. However, therapies affecting monocyte and macrophage activity, such as corticosteroids or anti-inflammatory agents, could indirectly influence CD163L1 expression and function.
   - Potentially relevant compounds might include those involved in modulating immune responses, such as:
     - Macrophage-targeting therapies: Drugs that affect polarization of macrophages (e.g., certain immunotherapies)
     - Anti-inflammatory agents that could influence the expression of receptor genes like CD163L1.

4. **Pathways and Biological Processes**:
   - **Immune Response**: CD163L1 is involved in the differentiation and activation of monocytes and macrophages, playing a role in innate immunity.
   - **Scavenger Receptor Activity**: It participates in the recognition and clearance of pathogens, cellular debris, and apoptotic cells, functioning in homeostasis and immune tolerance.
   - **Endocytosis**: As a scavenger receptor, it may facilitate the uptake of various ligands via endocytosis.
   - **Protein Binding and Interaction**: The SRCR domains contribute to interactions with ligands, influencing cell signaling pathways related to inflammation and immune regulation.
   - **Inflammatory Response**: CD163L1's expression is particularly relevant in the context of inflammation, where it may modulate macrophage responses to pro-inflammatory signals.

Overall, CD163L1 plays a crucial role in immune functions, particularly in monocyte and macrophage populations, with potential implications in age-related immune decline and inflammatory diseases. Further research is warranted to explore its therapeutic potential and interactions with medications.