### ARHGAP28 Gene Overview

**Gene Symbol:** ARHGAP28  
**Location:** Chromosomal location varies; please check specific assemblies for precise coordinates.  
**Protein Product:** The gene encodes a protein predicted to have GTPase activator activity, particularly for Rho-type GTPases. This protein is involved in the hydrolysis of GTP to GDP, effectively inactivating signaling via these GTPases.

### 1. Associated Genes
While the summaries provided do not mention specific genes associated with ARHGAP28, it is known to interact with several other genes involved in Rho GTPase signaling pathways and actin filament dynamics. Some of these may include:
- **RHOA**: A well-characterized Rho GTPase that regulates various cellular processes.
- **RAC1**: Another Rho GTPase that is critical for actin organization and cell signaling.
- **CDC42**: A Rho GTPase involved in establishing cell polarity and cytoskeletal dynamics.

### 2. Aging and Age-Related Diseases
ARHGAP28's role as a GTPase activator suggests it may be involved in fine-tuning cellular signaling and cytoskeletal organization, both critical for cellular health and function. Dysregulation of GTPase activity can lead to:
- **Cancer**: Abnormal signaling through Rho GTPases is frequently observed in various cancers, promoting malignant characteristics.
- **Neurodegenerative diseases**: Rho GTPases have been implicated in the regulation of neuronal integrity and function, and changes in their signaling may contribute to aging-related neurodegenerative conditions.

Additionally, studies have suggested that GTPase regulators can influence processes such as cellular senescence, apoptosis, and inflammation—all connected to aging and age-related diseases.

### 3. Drug Interactions
At the time of the last update, specific drugs or drug classes targeting ARHGAP28 directly were not extensively documented. Nonetheless, classes of drugs that might indirectly affect the activity of this gene include:
- **Rho kinase inhibitors**: As Rho GTPases and their modulation are critical for cancer treatment, drugs in this category might influence signaling pathways regulated by ARHGAP28.
- **Small molecule inhibitors of GTPase activation**: These could potentially impact ARHGAP28 function, although specific inhibitors are not direct drugs targeting this gene.

Further research may clarify if any specific drugs target ARHGAP28 or its associated pathways.

### 4. Involvement in Pathways and Biological Processes
ARHGAP28 is implicated in various pathways and biological processes, including:
- **Regulation of actin filament organization**: It plays a prominent role in cytoskeletal dynamics, essential for processes such as cell migration, adhesion, and division.
- **Small GTPase-mediated signal transduction**: Involved in multiple signaling cascades that affect cell survival, proliferation, and differentiation.
- **Negative regulation of GTP binding activity**: By converting GTP-bound Rho GTPases to their GDP-bound inactive form, it modulates cellular responses to extracellular signals.

Overall, ARHGAP28 may be crucial for maintaining cellular homeostasis through its regulatory functions within critical signaling pathways, with implications in various physiological and pathological processes, especially in the context of aging and disease. 

For the latest studies and specific interactions, researchers should consult recent literature and databases to confirm ongoing developments.