### GNA13 Gene Overview

**Gene Symbol:** GNA13  
**Location:** Cytosol and nucleus  
**Gene Product:** Guanine nucleotide-binding protein

#### 1. Associated Genes
GNA13 is associated with several genes, primarily through its involvement in signaling pathways and cellular processes. Some relevant associated genes include:

- **RHOA**: This gene encodes RhoA, a small GTPase that is activated by GNA13 and is involved in cytoskeletal dynamics and cell signaling.
- **ARHGEF1 (p115RhoGEF)**, **ARHGEF11 (PDZ-RhoGEF)**, **ARHGEF12 (LARG)**: These guanine nucleotide exchange factors (GEFs) activate RhoA in response to signals that involve GNA13.
- **CDH1 (E-cadherin)**: Involved in cell adhesion and may have functions regulated by GNA13 activity.

#### 2. Aging and Age-Related Diseases
GNA13 has been predicted to play a role in processes related to multicellular organism aging. While specific age-related diseases are not extensively documented within the available resources, disruptions in Rho signaling pathways (which GNA13 influences) have been linked to various conditions such as cancer and cardiovascular diseases, which can be influenced by aging. Specifically, the inhibition of vascular smooth muscle cell migration and proliferation may suggest relevance to age-related vascular changes.

#### 3. Drug Interactions
While specific drug names may not be directly annotated for GNA13 in the available summaries, G-proteins like GNA13 are commonly influenced by:

- **Phospholipase inhibitors**: Since GNA13 is involved in activating phospholipase D, inhibitors of this pathway may serve as indirect modulators.
- **Drugs targeting RhoA signaling**: Compounds that modulate RhoA activity or its downstream effects (like ROCK inhibitors—Rho-associated protein kinase inhibitors) could potentially interact with pathways involving GNA13.

#### 4. Pathways and Biological Processes
GNA13 is involved in several key signaling pathways and biological processes:

- **Rho protein signal transduction**: GNA13 plays a crucial role in activating RhoA, which regulates cytoskeletal dynamics and cell migration.
- **Activation of phospholipase D activity**: This can lead to alterations in membrane dynamics and lipid signaling.
- **Multicellular organism aging**: Although specific mechanisms are less defined, the involvement in vascular and cellular homeostasis aligns with age-related processes.
- **Branching involved in blood vessel morphogenesis**: GNA13's signaling influence extends to developmental biology, particularly in angiogenesis and blood vessel formation.
- **Negative regulation of vascular-associated smooth muscle cell functions**: The gene appears to inhibit both migration and proliferation of these cells, which is vital in cardiovascular health.

### Summary
GNA13 is a complex gene involved in crucial signaling pathways regulating cellular functions, especially in relation to the cytoskeleton and vascular biology. Its association with aging processes and potential roles in cancer metastasis highlight its significance in both normal physiology and disease states. Understanding GNA13 interactions and pathways further could provide insights into therapeutic targets for age-related diseases and malignancies.