### FBXL13 Gene Overview

**Gene Symbol**: FBXL13  
**Location**: The FBXL13 gene is located on chromosome 10 in humans.

#### Protein Summary
FBXL13 encodes a protein that is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. This complex is crucial for the ubiquitin-proteasome system, which regulates protein degradation. Beyond its role in ubiquitination, FBXL13 is also involved in the nexin-dynein regulatory complex (N-DRC), which is vital for ciliary and flagellar motility. Notably, it facilitates the ubiquitin-mediated proteolysis of CEP192 isoform 3, thereby regulating microtubule nucleation activity.

### 1. Associated Genes
While FBXL13 is known to interact with CEP192, studies also suggest potential associations with the following genes involved in similar cellular mechanisms:
- **SKP1**: A core component of the SCF complex that interacts with FBXL13.
- **CUL1**: Another critical structural component of the SCF-type E3 ubiquitin ligase complex.
- **CEP152**: Known to interact with CEP192 and involved in the same processes of centriole biogenesis.

### 2. Aging and Age-Related Diseases
Currently, there is limited direct research specifically linking FBXL13 to aging or age-related diseases. However, since FBXL13 is involved in microtubule organization and ciliary function, defects in these areas can contribute to age-related conditions:
- **Neurodegeneration**: Changes in microtubule dynamics are associated with neurodegenerative diseases.
- **Ciliary Dysfunctions**: Impairment in ciliary function has been associated with various age-related pathologies, including kidney disease and certain neurodegenerative disorders.

### 3. Drug Interactions
There is currently no exhaustive list of specific drugs or drug classes known to interact directly with FBXL13. However, given its role in ubiquitin-proteasome pathways, it is conceivable that compounds affecting the ubiquitin-proteasome system might impact FBXL13 activity or expression. Potential categories include:
- **Proteasome inhibitors**: Used in cancer therapy such as Bortezomib, which could indirectly affect the substrates recognized by FBXL13.
- **Cilium-targeting therapies**: Drugs that target ciliopathies could eventually relate to FBXL13 due to its role in ciliary function.

### 4. Pathways and Biological Processes
FBXL13 is involved in several significant biological pathways and processes:
- **Ubiquitin-mediated proteolysis**: As a component of the SCF E3 ubiquitin ligase complex, it plays a key role in tagging proteins for degradation.
- **Ciliary function**: It is part of the nexin-dynein regulatory complex, critical for maintaining cilia and flagella structure and function.
- **Centriole and microtubule organization**: It regulates microtubule nucleation, which is essential for proper cell division, intracellular transport, and overall cellular structure.

In summary, FBXL13 is a vital component of cellular pathways that influence both proteostasis and ciliary integrity, with indirect implications for aging and related diseases. Further research could clarify its explicit roles and potential therapeutic contexts.