### PECR Gene Overview

**Gene Symbol:** PECR  
**Full Name:** Peroxisomal trans-2-enoyl-CoA reductase  
**Location:** Peroxisome  
**Key Activities:** 
- Signaling receptor binding activity
- Trans-2-enoyl-CoA reductase (NADPH) activity

**Function:**
The PECR gene encodes an enzyme that participates in the chain elongation of fatty acids by catalyzing the reduction of trans-2-enoyl-CoAs, primarily with lengths ranging from 6:1 to 16:1, with maximum activity at 10:1 CoA. It is specifically noted to lack 2,4-dienoyl-CoA reductase activity.

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### 1. Associated Genes
PECR is associated with several genes involved in fatty acid metabolism and peroxisome function, such as:
- **ACOX1**: Acyl-CoA oxidase 1, involved in the first step of peroxisomal β-oxidation of fatty acids.
- **EHHADH**: Enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase, part of the fatty acid oxidation process.
- **PEX genes**: Peroxin genes that are crucial for peroxisome biogenesis and function; mutations in these can affect PECR function indirectly.

### 2. Aging and Age-Related Diseases
While specific studies linking PECR directly to aging or age-related diseases may be limited, its role in fatty acid metabolism and peroxisome function positions it as a potentially relevant factor in conditions such as:
- **Neurodegenerative diseases**: Impairments in fatty acid metabolism have been implicated in disorders like Alzheimer’s disease.
- **Metabolic syndrome**: Involvement in metabolic processes may suggest a role in age-related metabolic conditions.

### 3. Drug Interactions
Currently, explicit drugs targeting PECR have not been widely reported. However, compounds that influence peroxisome biogenesis or fatty acid metabolism may indirectly affect its activity. Potential drug interactions could include:
- **Fibrates**: A class of drugs used to lower lipid levels, known to impact fatty acid metabolism.
- **Statins**: While primarily targeting cholesterol synthesis, they may have downstream effects on related metabolic pathways.

### 4. Pathways and Biological Processes
PECR is involved in several biological pathways and processes, including:
- **Fatty Acid Metabolism**: Key role in the elongation of fatty acids.
- **Phytol Metabolic Process**: Enzymatic actions related to the metabolism of phytol, a component derived from chlorophyll.
- **Peroxisomal Beta-Oxidation**: Although PECR does not engage in beta-oxidation, it is associated functionally within the peroxisomal fatty acid breakdown context.
- **Lipid Metabolism**: General fatty acid and lipid homeostasis and processing.

### Conclusion
The PECR gene is critical for certain metabolic processes within peroxisomes, especially in the context of fatty acid metabolism. Its precise role in age-related conditions and potential interactions with therapeutic agents represent areas for further exploration, particularly as they relate to broader metabolic disorders and neurodegeneration in aging.