### PHACTR4 Gene Overview

**Gene Symbol**: PHACTR4  
**Location**: Chromosome X (Xq22.3)

**Function**: The PHACTR4 gene encodes a protein that is part of the phosphatase and actin regulator (PHACTR) family. This gene plays a crucial role in regulating protein phosphatase 1 (PP1) activity, which is vital for various cellular processes, including development. It is especially important for neural tube closure and the migration of enteric neural crest cells (ENCCs). 

### Additional Information

1. **Associated Genes**: 
   - PHACTR4 interacts with **PPP1CA** (Protein Phosphatase 1, Catalytic Subunit Alpha), which is critical for its regulation of PP1 activity.
   - **COF1** and **COF2** (Cofilin homologs) are also associated with PHACTR4's role in regulating actin dynamics through dephosphorylation.
   - Other potential interactors may include components of the **RHO/ROCK signaling pathway**, although specific genes were not mentioned in the summaries provided.

2. **Aging and Age-Related Diseases**: 
   - While direct associations between PHACTR4 and aging or specific age-related diseases are sparse, its role in developmental processes implicates it in the maintenance of cellular functions. 
   - Dysregulation of phosphatase activity has been associated with neurodegenerative disorders, such as Alzheimer's disease, making PHACTR4 a potential player in aging-related pathology, although research in this area is still ongoing.

3. **Drug Interactions**: 
   - Currently, there are no specific drugs or drug classes reported to interact directly with PHACTR4. However, as it influences PP1 activity, it could potentially be affected by drugs that target pathways involving protein phosphatases, but direct evidence is limited.

4. **Pathways and Biological Processes**: 
   - **Neural Development**: Critical for neural tube closure and neural crest cell migration.
   - **Cell Proliferation Regulation**: Modulates cell growth in cranial neural tissues and retina.
   - **Actin Regulation**: By activating PP1, it facilitates the dephosphorylation of actin-regulating proteins like cofilin, influencing cytoskeletal dynamics.
   - **Integrin Signaling**: Influences cell adhesion and migration by modulating signaling pathways, particularly through the RHO/ROCK pathway.

### Summary

The PHACTR4 gene is essential for various developmental processes, particularly those related to the nervous system. While there are many aspects of its gene interactions and pathways that are well-characterized, ongoing research may unveil deeper connections with aging and disease mechanisms, as well as therapeutic avenues for conditions related to aberrant cell signaling and migration.