### NEURL4 Gene Overview

**Gene Symbol**: NEURL4  
**Location**: Human chromosome 19  
**Protein Length**: The NEURL4 protein comprises 294 amino acids.

**Function**: The NEURL4 gene encodes a protein involved in cellular processes related to microtubule organization, particularly at the centrosome. Its key function includes promoting the ubiquitination and subsequent proteasome-dependent degradation of CP110, a regulatory protein critical for centriolar function and mitotic spindle assembly. By regulating CP110 levels, NEURL4 is essential for maintaining centriolar homeostasis and preventing the formation of ectopic microtubule organizing centers, which may lead to aberrations in cell division.

### Associations with Other Genes

While the summaries provided do not specify additional associated genes, NEURL4 may interact functionally with:

- **CP110**: Directly regulated by NEURL4 as described.
- **CDK5**: Known to have roles in cell cycle and neurodevelopment, may interact indirectly.
- **Aurora Kinases**: Involved in cell cycle regulation and may relate to microtubule dynamics.

### Aging and Age-Related Diseases

Though not explicitly detailed in the summaries, perturbations in centriole function and microtubule organization can be associated with several age-related conditions:

- **Neurodegenerative Diseases**: Proper centrosome function is vital for neuronal maintenance, and defects related to NEURL4 might contribute to conditions like Alzheimer's disease or Parkinson's disease, where microtubule dynamics are disrupted.
- **Cancer**: Abnormalities in centrosome duplication and mitotic spindle assembly have been linked to tumorigenesis, suggesting possible roles for NEURL4 in cancer development or progression.

### Drug Interactions

There are no definitive drug or drug class interactions specified for NEURL4 based on current available databases. However, drugs that modulate the ubiquitin-proteasome pathway could potentially influence the activity associated with NEURL4 indirectly.

### Pathways and Biological Processes

NEURL4 is involved in several key biological pathways:

1. **Cell Cycle Regulation**: Regulates the transition between different phases of the cell cycle through its influence on CP110 levels, critical for proper mitosis.
2. **Centrosome Cycle**: Involved in maintaining centrosome integrity and function.
3. **Ubiquitin-Proteasome Pathway**: Participates in protein degradation processes that are essential for cellular homeostasis and signaling.

In summary, NEURL4 is a critical player in cellular and microtubule dynamics, with implications for age-related neurodegeneration and cancer through its role in centrosome regulation. Further research may uncover more about its potential as a therapeutic target in age-related diseases and beyond.