### Gene Overview: SEMA6C

**Gene Symbol:** SEMA6C  
**Location:** Chromosome 3q26.32  
**Function:** The SEMA6C gene encodes a member of the semaphorin family, which plays significant roles in neuronal development and guidance. This gene is important in nervous system function and may also be implicated in neural regeneration processes following central nervous system (CNS) injuries. 

### 1. Associated Genes
SEMA6C has been studied in relation to several other genes, including but not limited to:
- **SEMA3A:** Another semaphorin involved in axon guidance.
- **NPR3:** A gene associated with natriuretic peptide signaling which may interact with semaphorins.
- **PLXNB1:** Plexin family members that act as receptors for semaphorins.
- **SLIT2:** Another guidance cue that interacts with semaphorin pathways.
- **ROBO1:** A receptor that mediates signals from Slit proteins which are involved in neuronal guidance.

### 2. Aging and Age-related Diseases
Current research indicates that SEMA6C may have implications in aging and neurodegenerative conditions due to its role in neuronal connections and regeneration. While the direct association of SEMA6C with specific age-related diseases is not extensively characterized, its involvement in nerve regeneration suggests that alterations in its expression or function could be linked to:
- **Alzheimer's Disease:** Impairments in neural signaling and connectivity.
- **Parkinson's Disease:** Given the importance of neuronal survival and remodeling.
- **Multiple Sclerosis:** As an example of CNS injury where semaphorins might play a role.

### 3. Drug Interactions
As of October 2023, there are no specific drugs or drug classes directly linked to SEMA6C in the literature. However, it is worth noting that several compounds affecting the semaphorin signaling pathways are being researched, particularly in the context of neuroregeneration. Some drugs targeting related pathways include:
- **Neuroprotective agents:** Compounds that may enhance neuronal survival and regeneration.
- **Angiogenic drugs:** Certain therapies that promote blood vessel formation in damaged tissues may indirectly affect semaphorin function.

### 4. Pathways and Biological Processes
SEMA6C is involved in several key pathways and biological processes, including:
- **Neurogenesis:** Regulation of neuronal development and differentiation.
- **Axon guidance:** Critical for proper wiring of the nervous system during development.
- **Synaptic remodeling:** Involved in maintaining and restructuring synaptic connections.
- **Cell migration:** Particularly in immune responses and nervous system development.
- **Semaphorin signaling:** Interacts with receptors (such as plexins) to transduce growth-inhibitory signals.
  
### Summary
SEMA6C is a crucial gene for understanding neuronal guidance, regeneration, and connectivity. Its role in neurobiology suggests that it could be a target of interest in aging-related neuronal disorders, although specific connections remain to be fully elucidated. Current investigations might further clarify its potential as a therapeutic target or biomarker in neurodegenerative diseases.