**NXPE3 Gene Overview:**

The NXPE3 gene (neurexophilin-3) encodes a glycoprotein that is part of the neurexophilin family. These proteins are known for their roles in neurobiology, particularly in synaptic adhesion and signaling processes due to their interaction with neurexins. 

### 1. Associated Genes:
While NXPE3 is primarily associated with neurexins, it may also have relationships with other genes involved in synaptic function and neurodevelopment. Other genes that might be correlated include various members of the neurexin family (e.g., **NRXN1**, **NRXN2**) and neuropeptide-related genes, although specific dosages or associations may vary.

### 2. Aging and Age-Related Diseases:
Research exploring the direct involvement of NXPE3 in aging or age-related diseases is limited; however, studies on the neurexophilin family have suggested roles in neuroplasticity and neuronal signaling, which are critical in aging and neurodegenerative diseases like Alzheimer's disease. Neurotransmitter system alterations affecting synaptic function are central to age-related cognitive decline, and NXPE3 may indirectly influence these processes.

### 3. Drug Interactions:
Currently, specific drugs or drug classes directly interacting with NXPE3 are not extensively documented. However, the neurexophilin protein family's interaction with synaptic components may suggest that research into neurotrophic factors or drugs affecting synaptic plasticity could reveal potential indirect interactions. Future pharmacological studies may yield new insights into specific compounds targeting neurexophilins or their pathways.

### 4. Pathways and Biological Processes:
NXPE3 is involved in several biological processes, including:
- **Neuronal development**: The protein's role in binding to neurexins contributes to the proper formation and maintenance of synapses.
- **Synaptic transmission**: By promoting adhesion between presynaptic and postsynaptic neurons, NXPE3 may regulate neurotransmitter release and receptor modulation.
- **Cell adhesion**: The protein is part of pathways that facilitate neuron-neuron adhesion.

While specific signaling pathways directly linked to NXPE3 are still under study, its interactions suggest involvement in major synaptic pathways, such as those governed by neurotrophins, and possibly, pathways related to synaptic remodeling and plasticity during learning and memory.

### Summary:
The NXPE3 gene encodes a protein critical to neuronal structure and function, particularly in synaptic dynamics. Although its direct links to aging and pharmacological applications remain less understood, the gene’s involvement in synaptic processes marks it as a candidate area for continued research in neurobiology, especially concerning age-related cognitive decline and neurodegenerative disorders.