### Gene Summary: SNORD115-8

**Gene Symbol:** SNORD115-8

SNORD115-8 is a small nucleolar RNA (snoRNA) that is part of the C/D box snoRNA family. This gene is located within the intron of the polycystin 1 (PKD1) gene in the human genome and plays a role in the post-transcriptional modification of ribosomal RNA (rRNA). Specifically, it is involved in guiding 2'-O-methylation of rRNA and other types of RNA, contributing to the proper assembly and function of the ribosome.

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### 1. Associated Genes

While NCBI and UniProt summaries may not explicitly list other associated genes, SNORD115-8 is known to overlap with the larger SNORD115 cluster, which includes several snoRNAs like SNORD115-1 to SNORD115-15. The gene is also situated within the intron of the PKD1 gene, which has important roles in polycystic kidney disease. It may also be associated with genes involved in RNA processing, ribosome biogenesis, and regulation of gene expression pathways.

### 2. Aging and Age-related Diseases

Current research indicates that snoRNAs, including SNORD115-8, may have roles in cellular aging and age-related diseases. For example, altered expressions of snoRNAs have been associated with neurodegenerative disorders such as Alzheimer's disease. While specific studies directly linking SNORD115-8 to aging are limited, the potential downstream effects associated with its targets in rRNA modifications may influence protein synthesis and cellular health during aging.

### 3. Drug Interactions

As of the last update, direct interactions of specific drugs with SNORD115-8 are not well-documented in official databases like DrugBank or ChEMBL. However, since SNORD115-8 influences ribosomal RNA modification, it may indirectly affect responses to certain therapeutic agents. Drugs targeting RNA processes, like those against viral infections or certain cancer treatments, could potentially interact with the pathways involving SNORD115-8 due to modifications in the ribosomal function.

### 4. Pathways and Biological Processes

SNORD115-8 is involved in the following biological processes and pathways:

- **Ribosome Biogenesis:** It plays a critical role in the maturation of rRNA, a vital aspect of ribosome assembly.
- **RNA Modification:** Acts as a guide for 2'-O-methylation of target RNAs, which is essential for proper processing and function of rRNA.
- **Gene Expression Regulation:** By modifying rRNA, it contributes to the fine-tuning of gene expression at the translational level.
- **Cellular Response to Stress:** Alterations in snoRNA levels have been linked to the cell’s response to stress, potentially influencing pathways linked to aging.

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In summary, SNORD115-8 is a key player in the regulation of rRNA, which has implications on cellular functions relevant to aging and disease states, although direct evidence linking this gene to specific therapeutic interventions or aging is still an area of active research.