### GPR75 Gene Overview

**Gene Symbol:** GPR75  
**Description:** GPR75 is a member of the G protein-coupled receptor (GPCR) family, specifically known to be activated by the chemokine CCL5 (also known as RANTES). Its activation is likely coupled to heterotrimeric Gq proteins, leading to intracellular signaling events such as inositol trisphosphate (IP3) production and calcium mobilization. This pathway suggests the potential role of GPR75 in various physiological processes, including neuron survival and insulin secretion.

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### 1. Associated Genes:
GPR75 has been noted to interact with several genes and proteins, especially those involved in signal transduction and metabolic pathways. While specific genes may not be documented uniformly across all sources, some genes associated with the CCL5 signaling pathway or that may be co-expressed with GPR75 include:
- **CCL5 (RANTES)**: The ligand that activates GPR75.
- **PIK3CA**: Involved in the PI3K/Akt signaling pathway affected by GPR75 activation.
- **AKT1**: Important for cell survival and metabolism pathways activated downstream of GPR75.
- **MAPK family members (e.g., MAPK1, MAPK3)**: Involved in the MAP kinase signaling cascade.
  
Investigations including co-expression and functional studies may highlight more genes associated with GPR75.

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### 2. Aging and Age-Related Diseases:
Research linking GPR75 directly to aging or age-related diseases is limited but potential associations can be inferred based on its signaling pathways:
- **Neurodegenerative Disorders**: Given GPR75's role in neuron survival, it may be implicated in conditions like Alzheimer's or other neurodegenerative diseases, where cell survival mechanisms are critically important.
- **Metabolic Disorders**: Since GPR75 may influence insulin secretion, variations in its function can be linked to aging-related metabolic diseases, including type 2 diabetes.
  
The role of GPR75 in signaling pathways that promote cell survival in differentiated tissues suggests potential relevance in age-related tissue degeneration.

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### 3. Drug Interactions:
Currently, there are limited specific drugs directly targeting GPR75. However, drugs that modulate chemokine receptors or are involved in inflammatory response pathways may indirectly affect GPR75 signaling. Some drug classes of interest include:
- **Chemokine antagonists**: These may interfere with CCL5 signaling.
- **G protein-coupled receptor modulators**: Could potentially influence the activity of GPR75 through broader GPCR pathways.
- **Anti-inflammatory agents**: These often target pathways involved in chemokine signaling and may modulate effects mediated by GPR75.

Ongoing research may yield specific pharmacological agents with targeted effects on GPR75 activity.

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### 4. Pathways and Biological Processes:
GPR75 is involved in several key pathways and biological processes, including:
- **G protein-coupled receptor signaling pathway**: A fundamental pathway for intercellular communication.
- **Calcium signaling pathway**: Activation of GPR75 leads to calcium mobilization which is critical for various cellular responses.
- **PI3K-Akt signaling pathway**: Plays a significant role in cell survival, growth, and metabolism, potentially regulated by GPR75.
- **MAPK signaling pathway**: Involved in various cellular responses, including growth, differentiation, and apoptosis.
- **Response to chemokine**: Particularly in immune response and inflammatory signaling.

In summary, the GPR75 gene plays a multifaceted role in cellular signaling, particularly related to survival and metabolic processes. The implications it holds in aging and disease as well as its potential therapeutic targets are areas of active research.