### MOB1A Gene Overview

**Gene Symbol:** MOB1A  
**Location:** Human chromosome 8q24.3  
**Protein Product:** MOB kinase activator 1A

#### Summary of Functions:
The MOB1A gene encodes a protein that is an essential component of the Hippo signaling pathway, which plays a critical role in regulating organ size, promoting apoptosis, and preventing tumorigenesis. Specifically, the MOB1A protein enhances the kinase activity of LATS1/2 proteins, which in turn phosphorylates YAP1 and WWTR1/TAZ, leading to the inhibition of genes that promote cell proliferation and survival.

### 1. Associated Genes:
In addition to the genes mentioned in the summaries (e.g., LATS1, LATS2, STK3/MST2, STK4/MST1, YAP1, WWTR1/TAZ), other proteins that may interact or be linked functionally with MOB1A include:
- **SAV1:** A regulatory protein that associates with STK3/MST2 and STK4/MST1 in the Hippo pathway.
- **STK38 & STK38L**: Kinases that are activated in conjunction with STK3/MST2, highlighting a connection between different signaling cascades.

### 2. Aging and Age-Related Diseases:
Research studies indicate that the Hippo signaling pathway, including MOB1A, plays a role in various age-related processes. Dysregulation of this pathway may contribute to aging phenotypes and age-related diseases such as:
- **Cancer:** Loss or mutation of MOB1A may lead to uncontrolled cell proliferation, crucial in cancer development.
- **Tissue Regeneration:** The Hippo pathway is involved in stem cell regulation and tissue repair, which tends to decline with age. Impairment of this signaling pathway could contribute to age-associated decline in regenerative capacity.

### 3. Drug Interactions:
Direct drug interactions specific to MOB1A are not well-documented as of the last update; however, drugs targeting components of the Hippo signaling pathway or related signaling cascades may indirectly affect MOB1A activity. Potentially relevant therapeutic classes include:
- **Anticancer agents:** Drugs that modulate YAP1 signaling or that target the broader Hippo pathway might have implications for pathways involving MOB1A.
- **Stabilizers of microtubules:** Since MOB1A is involved in microtubule stability during cytokinesis, compounds affecting microtubule dynamics could influence its function.

### 4. Pathways and Biological Processes:
MOB1A is involved in several biological processes and pathways, including:
- **Hippo signaling pathway:** Primarily, as a crucial activator of LATS1/2, regulating organ size and growth suppression.
- **Cytokinesis:** Participates in regulating microtubule stability and the proper separation of cells during division.
- **Apoptosis:** Influences programmed cell death pathways by modulating the activity of pro-survival factors such as YAP1.
- **Cellular response to stress:** Contributes to cellular responses that involve growth arrest and apoptosis in unfavorable conditions.

### Conclusion:
MOB1A plays a pivotal role in maintaining cellular homeostasis through its impact on the Hippo signaling pathway, functioning not only in tumor suppression but also in regulating cell cycle progression. Its involvement in various biological processes suggests potential avenues for therapeutic interventions in cancer and age-related diseases. Further studies are needed to fully elucidate the extent of its interactions and implications.