### CCDC90B Gene Overview

**Gene Symbol**: CCDC90B  
**Location**: Mitochondrion  
**Protein Summary**: Interacts with the mitochondrial calcium uniporter (MCU), suggesting a role in regulation of calcium homeostasis within mitochondria.

#### 1. Associated Genes
While explicit associations of CCDC90B with other genes are less commonly documented outside specialized research, it has been implicated alongside other genes involved in mitochondrial functions and calcium signaling. Some notable associations may include:
- **MCU (Mitochondrial Calcium Uniporter)**: Directly interacts with CCDC90B.
- **SLC8A3**: Involved in calcium transport, potentially related through calcium signaling pathways.
- **SPG11**: Mutations in this gene affect mitochondrial function indirectly.

Further studies may elucidate additional gene partners through functional genomics and proteomics.

#### 2. Aging and Age-Related Diseases
Currently, specific studies directly linking CCDC90B to aging or age-related diseases are limited. However, given its role in mitochondrial calcium regulation, it can be hypothesized that disturbances in CCDC90B functions may contribute to conditions often associated with cellular aging, such as:
- **Mitochondrial dysfunction**: Impairment of mitochondrial function is a hallmark of aging.
- **Neurodegenerative Diseases**: Since calcium dysregulation plays a role in diseases like Alzheimer’s and Parkinson’s, any pathological changes in CCDC90B could potentially influence the onset or progression of these conditions.

More research is needed to formally establish these connections.

#### 3. Drug Interactions
As of now, there are no specific drugs or drug classes widely recognized to interact directly with the CCDC90B gene. However, considering its role in mitochondrial calcium regulation, it could indirectly relate to drugs or compounds that influence mitochondrial functions or calcium homeostasis. Some examples may include:
- **Calcium Channel Blockers**: These might have downstream effects on mitochondrial calcium levels, potentially relating to CCDC90B activity.
- **Mitochondria-targeted antioxidants**: Although not directly interacting with CCDC90B, these could be relevant due to shared pathways involving mitochondrial stress.

#### 4. Pathways and Biological Processes
CCDC90B is involved in the following biological processes:
- **Calcium Ion Transport**: Specifically within the mitochondria, influencing energy metabolism and apoptotic signaling.
- **Mitochondrial Dynamics**: Participation in maintaining the functional integrity of mitochondria affects several physiological pathways.
- **Cellular Metabolism**: Due to its interaction with MCU, CCDC90B is likely involved in pathways related to energy production and metabolic balancing.

**Pathways** where CCDC90B might play a role include:
- **Mitochondrial Calcium Signaling Pathway**: A critical regulator of mitochondrial functions.
- **Apoptotic Pathway**: Since calcium overload in mitochondria can trigger programmed cell death.
- **Bioenergetics Pathways**: Relevant in ATP production and metabolic regulation.

In summary, research on CCDC90B indicates its importance in mitochondrial function and calcium homeostasis. Further investigations are warranted to elucidate its roles in aging, disease associations, and potential pharmacological interactions.