### GAPDHP63 Gene Overview

**Gene Symbol:** GAPDHP63

**Description:**
The GAPDHP63 gene encodes a protein that is a member of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) family. It is involved in several critical biological processes, primarily linked to cellular metabolism and energy production. The specific function and regulatory mechanisms of GAPDHP63 are still being studied and more detailed functional annotations may be needed for a comprehensive understanding.

### 1. Associated Genes
While the summaries from NCBI and UniProt may not detail all relationships, GAPDHP63 is likely to be associated with other genes involved in metabolic pathways, cellular respiration, and possibly other regulatory genes related to stress response or oxidative stress. Some related genes often include:

- **GAPDH**: The most direct homologous gene known for its role in glycolysis.
- **PGK1**: Phosphoglycerate kinase 1, which is involved in the energy metabolism pathway.
- **LDHA**: Lactate dehydrogenase A, also important in metabolic processes.

Note: For a more precise listing of associated genes, specific databases such as STRING or Ensembl may provide additional interactions based on gene co-expression or pathway analysis.

### 2. Aging and Age-Related Diseases
GAPDHP63 has been implicated in processes related to oxidative stress and cellular metabolism, both of which are significant factors in aging and age-related diseases. Various studies have suggested that dysfunctional glycolysis and altered cellular metabolic functions are associated with age-related diseases, including:

- **Neurodegenerative diseases**: There may be a connection between GAPDH and neurodegenerative processes, considering its role in energy metabolism and involvement in apoptosis and stress responses.
- **Diabetes**: Age is a significant risk factor, and dysregulated glycolytic pathways can lead to insulin resistance and related complications.
- **Cardiovascular diseases**: Aging affects metabolism and energy production in heart tissues which may relate to GAPDHP63’s function.

### 3. Known Drug Interactions
As of October 2023, specific drug interactions with the GAPDHP63 protein have not been comprehensively cataloged. However, given its metabolic role, it may be indirectly affected by:

- **Metformin**: Often used in diabetes management, impacting pathways related to glycolysis.
- **Antioxidants**: Compounds that mitigate oxidative stress may interact with the biological pathways in which GAPDHP63 is involved.

For more detailed pharmacological interactions, consulting databases like DrugBank could offer insights, though specific interactions with GAPDHP63 may need further research.

### 4. Pathways and Biological Processes
GAPDHP63 is involved in several key biological pathways:

- **Glycolysis pathway**: Fundamental for glucose metabolism and energy production.
- **Glycerolipid metabolism**: This pathway impacts lipid synthesis and metabolism, with potential implications in metabolic disorders.
- **Cellular response to oxidative stress**: The gene likely plays a role in cellular defense mechanisms against oxidative stress, which is critical in both aging and disease processes.

In summary, the GAPDHP63 gene is involved in essential metabolic processes and may have implications in both aging and metabolic diseases, as well as interactions with various biological pathways that merit further exploration in research studies.