### SNORD115-43 Gene Overview:

**Gene Symbol:** SNORD115-43  
**Type:** Small nucleolar RNA (snoRNA)  
**Location:** SNORD115-43 is located within the introns of the **UBE3A** gene on chromosome 15. It is part of the SNORD115 (also referred to as U85) gene cluster.

### 1. Associations with Other Genes:

The SNORD115 gene cluster, including SNORD115-43, has been associated with several genes primarily involved in gene regulation and imprinting, notably:

- **UBE3A**: As mentioned, it is embedded in the UBE3A gene, which is crucial in the context of Angelman syndrome. 
- **UBE3B**: Another gene that is closely related to UBE3A and may share functional processes.
- **SNORD115 (full cluster)**: The larger gene cluster contains several snoRNAs that may co-regulate various biological processes.

### 2. Age and Age-Related Diseases:

There is emerging evidence that disruptions in snoRNA processing and function can influence the regulation of genes associated with aging and age-related diseases. Specific details about SNORD115-43 in the context of aging are limited, but here are some relevant points:

- **UBE3A and Aging**: The UBE3A gene, in which SNORD115-43 is located, occasionally has been linked to neurodegenerative conditions due to its role in protein degradation and cellular stress responses, which can be affected by aging.
- The SNORD115 genes may play a role in neurological function and could be implicated in age-related cognitive decline.

### 3. Drug Interactions:

Currently, there are no specific drugs or drug classes known to directly interact with SNORD115-43. However, therapeutic approaches targeting UBE3A or related neural pathways may indirectly influence the expression or function of snoRNAs, including SNORD115-43.

### 4. Pathways and Biological Processes:

SNORD115-43 is involved in several biological processes:

- **rRNA Modification**: As part of the snoRNA family, SNORD115-43 is primarily involved in the post-transcriptional modification of ribosomal RNA (rRNA), essential for ribosome biogenesis and function.
  
- **Gene Regulation**: It may play a role in the regulatory mechanisms involving UBE3A, thus affecting gene expression patterns related to embryonic development and neurogenesis.

- **Imprinting**: The location of SNORD115-43 within the UBE3A gene suggests it might also be involved in the regulation of genomic imprinting, particularly in the context of parental allele-specific expression.

### Conclusion:

In summary, SNORD115-43 is a small nucleolar RNA associated with the UBE3A gene, which plays vital roles in rRNA modification and potentially impacts aging and neurological diseases. While direct drug interactions are not established, its involvement in important biological processes underscores its relevance in gene regulation and cellular function related to health and disease. Further research is needed to elucidate its precise roles and interactions.