### RNA5SP488 Gene Overview

**Gene Symbol:** RNA5SP488

The RNA5SP488 gene is known to encode a small nucleolar RNA (snoRNA) primarily involved in the modification of other RNA molecules, particularly ribosomal RNA (rRNA). This gene is classified as a member of the C/D box snoRNAs, which are often implicated in guiding the methylation of rRNA.

### Associated Genes

While specific associations may not be explicitly outlined in the provided summaries, snoRNAs often act in conjunction with other genes involved in ribosome biogenesis and ribosomal protein synthesis. Some genes that may be functionally related to snoRNAs and thereby indirectly associated with RNA5SP488 include:

- **NOP58**: A component of the snoRNP complex.
- **NOL1/NOP2/Sun RNA methyltransferase family**: Involved in rRNA methylation processes.
- **RPS genes**: Genes encoding ribosomal proteins, which may be co-regulated with snoRNA expression.

### Age-Related Information

Current literature does not provide definitive details specifically linking RNA5SP488 to aging or age-related diseases. However, since snoRNAs, in general, are involved in ribosomal RNA processing and modification, any perturbations in snoRNA functions could impact cellular protein synthesis, potentially contributing to aging processes and age-related diseases. Dysregulation of ribosomal function has been implicated in various age-associated disorders.

### Drug Interactions

As of the last update in October 2023, there are no specific drugs or drug classes definitively known to interact with RNA5SP488. Research into small nucleolar RNAs often focuses on their regulatory roles rather than direct pharmacological interactions.

### Pathways and Biological Processes

RNA5SP488 is involved in several biological processes, particularly:

- **Ribosome Biogenesis**: It plays a role in the processing and modification of rRNA, essential for ribosome assembly and function.
- **Gene Expression Regulation**: SnoRNAs are also associated with regulating the expression of certain genes through mechanisms such as RNA processing and modification.
- **RNP Complex Formation**: Becomes part of the small nucleolar ribonucleoproteins (snoRNPs), contributing to the complex dynamics of RNA modification.

Overall, while RNA5SP488 serves important functions within the cell related to RNA modification, further research is necessary to elucidate any more direct links to specific diseases, aging, or drug interactions.