**TNFRSF1B Gene Overview:**
The TNFRSF1B gene, also known as tumor necrosis factor receptor superfamily member 1B (TNF receptor 2, TNFR2), encodes a receptor that is part of the TNF receptor superfamily. It is involved in various signaling pathways that influence cell survival and apoptosis, particularly in neuronal tissue and other cell types.

### 1. Associated Genes:
TNFRSF1B interacts with several other genes/proteins, including:
- **TRAF1 (TNF receptor-associated factor 1)** 
- **TRAF2 (TNF receptor-associated factor 2)** 
- **BIRC2 (Baculoviral IAP repeat-containing protein 2)** 
- **BIRC3 (Baculoviral IAP repeat-containing protein 3)** 
- **c-IAP1 (inhibitor of apoptosis protein 1)** 
- **c-IAP2 (inhibitor of apoptosis protein 2)** 
- **TNFRSF1A (TNF receptor superfamily member 1A)**

These genes are involved in the apoptotic signaling pathways, as well as in the recruitment and regulation of proteins that mediate apoptosis and cell survival.

### 2. Aging and Age-Related Diseases:
- **Neuroprotection**: Knockout studies suggest that TNFRSF1B plays a protective role in neurons against apoptosis. The receptor's activity in stimulating antioxidative pathways may be relevant in aging, where oxidative stress is a contributing factor.
- **Inflammatory Diseases**: Dysregulation of TNFRSF1B signaling has been implicated in various age-related inflammatory diseases, including Alzheimer's disease, where chronic inflammation and neuronal death are observed.
- **Cancer**: TNFRSF1B may also be involved in the aging process related to cancer, as tumor microenvironments often leverage TNF signaling for promoting tumor growth and evading apoptosis. 

### 3. Drug Interactions:
Drugs and classes known to interact with TNFRSF1B include:
- **TNF Inhibitors**: Biologics such as infliximab, etanercept, and adalimumab are designed to block TNF-alpha signaling and could potentially affect the function of TNFRSF1B.
- **Immunomodulators**: Drugs used in the treatment of autoimmune diseases may modulate the function of TNFRSF1B indirectly through TNF-alpha pathways.

### 4. Pathways and Biological Processes:
TNFRSF1B is involved in the following pathways and biological processes:
- **Apoptotic Signaling**: It plays a crucial role in mediating apoptotic signals induced by TNF-alpha while also promoting survival through interactions with c-IAP1 and c-IAP2.
- **Cell Survival and Proliferation**: Activation of TNFRSF1B leads to the recruitment of TRAFs which can activate NF-kB and MAPK pathways, promoting cell survival and proliferation.
- **Inflammatory Response**: The receptor mediates metabolic effects of TNF-alpha, influencing inflammation.
- **Neuroprotection**: As mentioned, it may help protect neurons against oxidative stress, linking it to neurodegenerative processes.

Overall, TNFRSF1B is a significant player in regulating apoptosis, cell survival, and the inflammatory response, with critical implications for aging and related diseases. Its interactions with other genes and pathways underscore its complexity and importance in cellular homeostasis.