### GPR84 Gene Overview

**Gene Symbol:** GPR84  
**Location:** Human chromosome 19q13.32  
**Gene Type:** Protein-coding gene

**Predicted Functions:**
- GPR84 is predicted to enable urotensin II receptor activity and is involved in the neuropeptide signaling pathway, indicating a role in neuronal communication.
- It acts as a receptor for medium-chain free fatty acids (FFAs) with carbon chain lengths ranging from C9 to C14. Notable agonists include capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0).
- The activation of GPR84 by medium-chain FFAs is linked to a pertussis toxin-sensitive G(i/o) protein signaling pathway, indicating a role in various physiological processes.

### Additional Details

1. **Associated Genes:**
   - Genes implicated in metabolic processes and inflammation are often associated with GPR84, such as:
     - **FFA1 (GPR40)** - involved in fatty acid sensing.
     - **GPR120** - another receptor involved in fatty acid signaling.
     - **CD36** - implicated in fatty acid metabolism and signaling.
     - Various genes related to the immune response (e.g. **IL6**, **TNF**) may show pathway intersections with GPR84.

2. **Aging and Age-Related Diseases:**
   - While specific studies exploring GPR84's role in aging are limited, its involvement in fatty acid metabolism and immune regulation suggests potential links to age-related metabolic syndromes and inflammatory diseases.
   - Given its role in inflammation and metabolic processes, dysregulation of GPR84 might be implicated in age-associated disorders such as obesity, insulin resistance, and chronic inflammatory diseases (such as atherosclerosis).

3. **Drug Interactions:**
   - Currently, there are no specific drugs or drug classes primarily recognized for direct interaction with GPR84.
   - However, compounds influencing fatty acid metabolism or known agonists (e.g., lauric acid) might indirectly impact pathways associated with GPR84 activity. Researchers are exploring the therapeutic potential of medium-chain fatty acids in various metabolic and inflammatory conditions, which could point to GPR84 as a target.

4. **Pathways and Biological Processes:**
   - GPR84 is involved in several biological processes, including:
     - **Neuropeptide signaling** - suggesting a potential role in neuroendocrine function.
     - **Fatty acid metabolic processes** - vital for energy metabolism.
     - **Immune response regulation** - linked to different inflammatory conditions.
     - **G-protein coupled receptor signaling pathways** - involved in the transduction of extracellular signals.

Given the pathways GPR84 is implicated in, ongoing research may unravel more specific associations with diseases and could contribute to targeted therapies, especially in metabolism and immune-related conditions.