### NUP58 Gene Overview

**Gene Symbol:** NUP58  
**Location:** Nucleus  
**Function:** Encodes a nucleoporin, part of the nuclear pore complex (NPC), facilitating transport between the nucleus and cytoplasm.

### 1. Associated Genes
NUP58 is part of a larger family of nucleoporins, and while specific gene associations can vary, the following genes are often linked either through functional relationships or pathways:

- **NUP54:** Another nucleoporin that forms part of the NPC.
- **NUP62:** Involved in the nuclear transport pathway and part of the NPC.
- **NUP153:** Nucleoporin that may play a role in chromatin organization and nuclear transport.
- **NUP96:** Works in conjunction with other nucleoporins at the nuclear pore complex.

Associations with genes involved in cell transport mechanisms, cellular aging, and even those related to chromatin dynamics could also be explored.

### 2. Aging and Age-related Diseases
While specific studies focusing solely on NUP58 and aging are limited, some relevant associations include:

- **Cellular Senescence:** Changes in nuclear transportation efficiency have been observed with aging, affecting cellular function. NUP58, as part of the NPC, may influence these processes.
- **Neurodegenerative Diseases:** Defects in nucleocytoplasmic transport (which involves nucleoporins) have been implicated in disorders like Alzheimer’s disease. While not directly proven to involve NUP58, it could play a role.
- **Cancer:** Altered expression of nucleoporins, including NUP58, has been reported in various cancers. Given the link between aging and cancer susceptibility, NUP58 could be indirectly related to age-associated oncogenesis.

### 3. Known Drug Interactions
Currently, there are no specific drugs that directly target NUP58. However, interactions with general classes of drugs may include:

- **Antivirals:** NUP58 plays a role in the nuclear import of viral proteins; thus, the effectiveness of certain antiviral agents might be influenced by its function.
- **Chemotherapeutics:** Some cancer treatments that aim to disrupt nuclear transport pathways may indirectly impact the function of nucleoporins, including NUP58.

### 4. Pathways and Biological Processes
NUP58 is involved in several critical pathways and biological processes:

- **Nuclear Transport:** Essential for the transport of proteins and RNA across the nuclear envelope.
- **Nuclear Pore Complex Assembly:** Plays a role in the structural formation and maintenance of the NPC.
- **Cell Cycle Regulation:** Involved in processes related to cell division, as nuclear transport is crucial during cell cycle transitions.
- **Response to Stress:** Engages in cellular responses to environmental and oxidative stress, impacting cell survival and function.

### Summary
The NUP58 gene plays an essential role in the structure and function of the nuclear pore complex, crucial for nucleocytoplasmic transport. Its involvement in cellular aging, neurodegenerative diseases, and cancer highlights its potential importance in both health and disease. Future research may further elucidate its role in various biological processes and its connections to therapeutic targets.