### NUP153-AS1 Gene Overview

**Gene Symbol**: NUP153-AS1  
**Location**: NUP153-AS1 is an antisense non-coding RNA associated with the NUP153 gene, which encodes a component of the nuclear pore complex involved in nucleocytoplasmic transport.

### 1. Associated Genes

NUP153-AS1 is primarily associated with the following genes:

- **NUP153**: The gene encoding the nucleoporin protein that plays a role in nuclear pore formation and function.
- **NUP50**: Another nucleoporin that can interact with NUP153 and is involved in nuclear transport processes.
- **MALAT1**: This is a well-studied lncRNA that can influence various cellular processes and gene expression and may have regulatory interactions with NUP153-AS1.

Additional associations that may be relevant include genes involved in transport and nuclear processes, although specific associations beyond those mentioned in existing summaries are less well-characterized.

### 2. Aging and Age-Related Diseases

While specific studies directly linking NUP153-AS1 to aging or age-related diseases are limited, several aspects can be inferred based on its association with nuclear transport processes:

- **Cellular Senescence**: Alterations in nucleocytoplasmic transport are thought to contribute to cellular senescence, a hallmark of aging.
- **Neurodegenerative Diseases**: Given its role in nuclear pore function, disturbances in NUP153 and related pathways may be associated with neurodegenerative disorders like Alzheimer’s disease, where nuclear transport is often impaired.
- **Cancer**: There is emerging evidence that lncRNAs, like NUP153-AS1, may play roles in cancer biology, which often reflects age-related changes in gene regulation.

### 3. Drug Interactions

As of the latest information available:

- There are no specific drugs or drug classes that are widely recognized to directly interact with NUP153-AS1. However, the pathways influenced by nucleoporins and nuclear transport machinery may be targets for drugs used in cancer treatment or aging-related therapies.
- Further investigation into cancer treatment modalities that impact nuclear transport or manipulate lncRNA expression may reveal indirect relationships to specific drugs.

### 4. Pathways and Biological Processes

NUP153-AS1 is involved in several pathways and biological processes, primarily via its association with nuclear pore function and transport mechanisms:

- **Nuclear Transport**: Facilitates the transport of molecules across the nuclear envelope.
- **Gene Expression Regulation**: May have potential roles in modulating gene expression through its interactions with chromatin and other regulatory elements.
- **Cell Cycle Progression**: Involved in processes that are critical for the proper timing and regulation of cell division.

In broader metabolic contexts, the lncRNA could play roles in these crucial processes, influencing various biological pathways that deal with cellular homeostasis and stress responses. 

### Conclusion

The NUP153-AS1 gene is an important non-coding RNA associated with nuclear pore functionality and various biological processes. Though direct associations with aging or specific drugs are not well established, its roles in nuclear transport may render it significant in the context of age-related changes and diseases. Further research could expand our understanding of its interactions and implications in health and disease.