### DLG1 Gene Overview

**Gene Symbol:** DLG1  
**Chromosomal Location:** Human chromosome 3q29  
**Function:** The DLG1 gene encodes a multi-domain scaffolding protein essential for normal developmental processes. It is known to interact with cell membranes and is involved in a variety of cellular functions, including septate junction formation, signal transduction, and synaptogenesis.

### 1. Associated Genes

While the summaries do not explicitly mention other genes associated with DLG1, several genes are known to interact or be functionally related to DLG1:

- **SHANK3:** A gene associated with synapse structure and function, which interacts with DLG1 in the context of synaptic signaling.
- **PSD-95 (DLG4):** Another member of the DLG protein family that shares functional roles.
- **GRIA (Glutamate Receptor, Ionotropic, AMPA):** These receptors are crucial in synapse-mediated communication and may interact with DLG proteins.
- **ADAM10:** An enzyme recruited by DLG1 during hippocampal long-term depression, involved in shedding proteins that are important for synaptic function.
- **KCN (potassium voltage-gated channel genes):** DLG1 modulates the function of Kv4 and Kv1.5 potassium channels, influencing cardiac and neuronal excitability.

### 2. Aging and Age-Related Diseases

- **Cardiovascular Health:** DLG1 has been implicated in regulating cardiac myocyte excitability, and dysregulation of this gene may contribute to age-related cardiac disorders, such as arrhythmias.
- **Neurodegenerative Diseases:** Given its critical role in synaptic function, abnormalities or decreased expression of DLG1 may be linked to neurodegeneration or cognitive decline with aging.
- **Cancer:** Altered expression of scaffolding proteins like DLG1 can affect cell proliferation and signal transduction pathways, potentially linking this gene to certain cancers that are more prevalent in aging populations.

### 3. Drug Interactions

While there are no specific drugs universally recognized for direct interaction with DLG1, it has been involved in pathways modulated by various classes of drugs:

- **Antiepileptic Drugs:** Due to its role in synaptogenesis and neuronal excitability, antiepileptic medications may indirectly influence DLG1-related signaling pathways.
- **Cardiovascular Drugs:** Medications modulating potassium channels (like Kv4 and Kv1.5) could thus be associated with the functionality of DLG1.
- **Neuroprotective Agents:** Compounds that target synaptic regulation may indirectly affect the expression or function of DLG1, especially in neurodegenerative contexts.

### 4. Pathways and Biological Processes

DLG1 is implicated in several key biological pathways and processes, including:

- **Cell Adhesion:** It plays a significant role in maintaining adherens junctions and cell polarity.
- **Signal Transduction:** Involved in various signaling pathways, including those regulating neuronal and lymphocyte activation.
- **Synaptogenesis:** Critical for the formation and maintenance of synapses in the nervous system.
- **Cell Proliferation:** DLG1 participates in pathways that regulate cell growth and division.
- **Lymphocyte Activation:** This gene has a role in the immune response as it is involved in the activation of lymphocytes.

**Key Biological Processes:**
- Developmental processes
- Ion channel regulation
- Cell signaling networks
- Synaptic transmission and plasticity

In summary, DLG1 is a multifaceted gene involved in key processes related to development, neuronal function, and potentially age-related health issues, with connections to various important signaling partners and functional pathways.