### Gene Overview: PPIAP14

**Gene Symbol:** PPIAP14  
**Description:** PPIAP14 (Peptidylprolyl Isomerase A-Associated Protein 14) is a gene that encodes a member of the peptidylprolyl isomerase family. These proteins play crucial roles in protein folding and are associated with various cellular processes.

### 1. Associated Genes

While the NCBI and UniProt summaries may not have mentioned them explicitly, PPIAP14 may be linked to several other genes in biological contexts, such as:

- **PPIA:** The main protein coding gene for peptidylprolyl isomerases.
- **PPIB:** Another member of the peptidylprolyl isomerase family.
- **CDK2:** Involved in cell cycle regulation.
- **HSP90AA1:** Stress response protein that may interact with PPIAP14 in protein handling mechanisms.

More research-focused functional genomics studies may provide insights into additional interacting partners.

### 2. Aging or Age-Related Diseases

There is a growing body of evidence suggesting that proteins within the peptidylprolyl isomerase family, including PPIAP14, play roles in cellular stress response mechanisms, which are critical in the aging process and age-related diseases. While specific studies on PPIAP14 can be limited, alterations in protein folding and aggregation pathways have implications in diseases such as:

- **Alzheimer's Disease:** Misfolded proteins are a hallmark of neurodegenerative disorders, and PPIAP14 may be involved in modulating the protein homeostasis.
- **Cancer:** Given the protein's role in cell cycle and growth regulation through its potential interactions, PPIAP14 may also implicate pathways that lead to tumorigenesis.

Further research is needed to pinpoint the exact role of PPIAP14 in these contexts.

### 3. Drug or Drug Classes

Currently, there may not be specific drugs or classes mentioned in the literature that directly target PPIAP14. However, general interactions with compounds affecting protein folding or chaperone activities may indirectly influence this gene's function. Some classes that may affect its activity indirectly could include:

- **Cyclosporin A:** This immunosuppressant drug can inhibit peptidylprolyl isomerases, and it could impact proteins related to PPIAP14.
- **HSP90 inhibitors:** Drugs targeting heat shock proteins may also affect protein interactions and folding pathways in which PPIAP14 is involved.

Comprehensive pharmacogenomic databases may provide updates as new studies emerge.

### 4. Pathways and Biological Processes

PPIAP14 is associated with several biological processes and pathways:

- **Protein Folding and Isomerization:** Participates in the proper folding of proteins and modulation of protein function.
- **Cell Cycle Regulation:** Involvement in cellular growth and division through interaction with cyclins and kinase pathways.
- **Response to Stress:** Mediates responses to various forms of cellular stress, including oxidative stress.
- **Metabolic Regulation:** Plays a potential role in metabolic pathways that involve protein modifications.

### Conclusion

PPIAP14 represents a key player within the peptidylprolyl isomerase family, with implications in several biological processes and potential relevance in aging and disease contexts. Further research is anticipated to clarify its functional relationships with other genes, its role in age-related mechanisms, and its potential as a therapeutic target.