### SNORD5 Gene Overview

**Gene Symbol:** SNORD5  
**Entrez Gene ID:** 11129  
**Location:** Chromosome 5

#### General Information
The SNORD5 gene encodes a small nucleolar RNA (snoRNA) that is involved in the modification of ribosomal RNA (rRNA). snoRNAs are primarily located in the nucleolus and play a critical role in the biogenesis of ribosomes by directing the chemical modifications of rRNA, mainly through methylation and pseudouridylation.

### 1. Associated Genes
While the summaries do not specify associated genes, SNORD5 is part of a larger family of snoRNAs. It is interconnected with other snoRNAs and is known to have potential associations with genes involved in ribosomal function and RNA processing. Some genes that may have interactions or regulatory relationships with SNORD5 include:

- **Nucleolar complex proteins (e.g., NOP56, NOP58)** - involved in snoRNP assembly and function.
- **Genes involved in ribosome biogenesis** may also be indirectly associated with SNORD5 due to its role in rRNA modification and processing.

### 2. Aging and Age-Related Diseases
The specific association of SNORD5 with aging or age-related diseases has not been extensively characterized in the literature. However, as snoRNAs like SNORD5 are crucial for ribosome biogenesis and cellular function, dysregulation of snoRNA expression has been linked to several age-related conditions:

- **Cancer:** Some studies have shown that alterations in snoRNA expression profiles can be associated with tumorigenesis.
- **Neurodegenerative Diseases:** Changes in snoRNA levels may be implicated in conditions such as Alzheimer's disease, although direct evidence linking SNORD5 specifically to these processes is limited.

### 3. Drug Interactions
Currently, there is no well-documented drug or drug class that directly interacts with the SNORD5 gene. However, certain treatments that target ribosomal biogenesis, nucleolar functions, or RNA processing may indirectly influence the expression or function of snoRNAs, including SNORD5. Examples may include:

- **Anticancer Drugs:** Some inhibitors of ribosome biogenesis could potentially affect snoRNA function.
- **Anti-inflammatory Drugs:** Since inflammation can influence snoRNA expression, treatments targeting inflammatory pathways could indirectly impact SNORD5.

### 4. Pathways and Biological Processes
SNORD5 is involved in several key biological processes, primarily related to RNA processing and ribosome biogenesis:

- **rRNA Methylation:** SNORD5 plays a role in guiding the methylation of specific rRNA nucleotides, which is essential for the proper functioning and stability of rRNA.
- **Ribosome Biogenesis:** By modulating rRNA, SNORD5 contributes to the formation and maturation of ribosomes, which are crucial for protein synthesis in cells.
- **Nucleolus Organization:** As a component of the nucleolus, SNORD5 is involved in maintaining proper nucleolar structure and function.

In summary, while SNORD5 plays a critical role in cellular processes associated with ribosomal function and rRNA modification, much research is still needed to elucidate its specific associations with aging, disease states, and potential interactions with therapeutic agents.