### TMEM147 Gene Summary

**Gene Symbol**: TMEM147  
**Location**: Endoplasmic reticulum membrane  
**Function**: Enables ribosome binding activity and is a component of the multi-pass translocon (MPT) complex involved in the insertion of multi-pass membrane proteins into lipid bilayers.

### Additional Information:

1. **Associated Genes**:
   - **CHRM3 (Cholinergic Receptor Muscarinic 3)**: TMEM147 negatively regulates CHRM3, impacting its trafficking to the cell membrane and thereby affecting downstream signaling pathways.
   - **RPS6KA1 (Ribosomal Protein S6 Kinase A1)**: The TMEM147 gene influences the activity of this kinase by modulating CHRM3-mediated calcium mobilization.
   - **LBR (Lamin B Receptor)**: TMEM147 is involved in regulating the localization of LBR to the nucleus inner membrane.

2. **Aging and Age-Related Diseases**:
   - There is limited direct research available specifically linking TMEM147 to aging or age-related diseases. However, since TMEM147 is involved in mechanisms pertinent to calcium signaling, cell signaling impairment, and the proper localization of membrane proteins, its dysregulation may contribute to cellular dysfunction seen in age-related diseases, including neurodegeneration and other metabolic syndromes. Understanding pathways where TMEM147 is implicated can suggest potential roles in aging.

3. **Drug Interactions**:
   - Specific drugs or drug classes directly interacting with TMEM147 have not been widely documented. However, drugs that affect cholinergic signaling or calcium mobilization, such as muscarinic antagonists (e.g., atropine), might influence pathways where TMEM147 is involved, considering its role in regulating CHRM3 function.

4. **Pathways and Biological Processes**:
   - **Protein Insertion and Translocation**: TMEM147 is part of the MPT complex, crucial for membrane protein biogenesis, especially for multi-pass membrane proteins.
   - **Calcium Signaling**: By regulating CHRM3, TMEM147 affects cellular calcium mobilization, which is essential in various signaling pathways.
   - **Endoplasmic Reticulum Functions**: As a component of the ER membrane, TMEM147 contributes to the overall function of the endoplasmic reticulum in protein synthesis and processing.
   - **Cellular Transport**: By impacting the trafficking of membrane proteins, TMEM147 plays a role in maintaining cellular compartmentalization and function.

This information presents a comprehensive overview of TMEM147’s role in cellular processes and its potential implications in health and disease. Future studies may further elucidate its relevance in aging and the pharmacological landscape.