### ZNF528 Gene Overview

**Gene Symbol:** ZNF528  
**Function:** ZNF528 encodes a protein that is predicted to function as a DNA-binding transcription factor. It is involved in the regulation of transcription by RNA polymerase II, specifically binding to cis-regulatory regions of genes to modulate their expression. The protein is believed to be localized in the nucleus, which is consistent with its role in transcriptional regulation.

### 1. Associated Genes
ZNF528 has been found to be associated with several genes, particularly those involved in transcriptional regulation. Some known associated or interacting genes include:
- **Zinc finger protein family members**: ZNF521, ZNF30
- **Other transcription factors**: SP1, NF-κB

Specific interactions or regulatory relationships can vary, and ongoing research may identify additional genes that interact with ZNF528 or that are transcriptionally regulated by it.

### 2. Aging and Age-Related Diseases
Research on ZNF528 in the context of aging and age-related diseases is still limited. However, some studies suggest that transcription factors, including those in the zinc finger family, may play a role in aging and cellular senescence. Certain transcription factors are known to influence gene expression patterns associated with longevity, cellular stress responses, and age-related diseases like cancer and neurodegeneration. Specific studies directly linking ZNF528 to aging are not well-established, although its involvement in transcription suggests that it could play a role in these processes.

### 3. Drug Interactions
As of the latest information available, ZNF528 does not have well-characterized direct interactions with specific drugs. However, it might indirectly affect drug response through its regulatory role over genes linked to drug metabolism or response pathways. Further studies might uncover interactions between ZNF528 expression and specific drug classes, especially those targeting cellular pathways related to transcriptional regulation. 

### 4. Pathways and Biological Processes
ZNF528 is involved in several biological processes and pathways, primarily related to transcriptional regulation. It may participate in:
- **Transcription regulation via RNA polymerase II**: This is a fundamental process governing gene expression.
- **Cellular signaling pathways**: Involved in various signaling cascades where transcription factors including ZNF528 help modulate gene expression based on cellular signals.
- **Developmental processes**: Though not specifically defined, transcription factors are often implicated in development and differentiation processes.

### Summary
The ZNF528 gene encodes a transcription factor with predicted roles in DNA binding and transcription regulation, notably within the nucleus. Its broader biological implications, particularly in aging and drug interactions, require further exploration to uncover definitive connections. Continued research into its associated genes, pathways, and roles in different biological contexts will help clarify its significance in health and disease.