### PRMT3 Gene Overview

**Gene Symbol**: PRMT3  
**Location**: Human Chromosome 2p24.1  
**Entrez Gene ID**: 5692  
**UniProt ID**: Q99807  

**Function**: The PRMT3 gene encodes a member of the protein arginine methyltransferase family, specifically involved in the methylation of arginine residues on target proteins. Its primary enzymatic action results in both monomethylation and asymmetric dimethylation of arginine residues. PRMT3 is known for its role in modifying the 40S ribosomal protein S2, contributing to the maturation of the 80S ribosome. Apart from its primary function, it also may play a regulatory role in retinoic acid synthesis by inhibiting the ALDH1A1 retinal dehydrogenase activity, crucial for proper cellular signaling.

### Gene Associations

1. **Associated Genes**: While the summary primarily mentions the ribosomal protein S2 and ALDH1A1, PRMT3 has also been linked to the following genes:
   - **PRMT5**: Another protein arginine methyltransferase involved in various cellular processes.
   - **p53 (TP53)**: Emerging evidence suggests potential interactions and regulatory roles during stress responses.
   - **pRb (RB1)**: May interact with PRMT3 in pathways that regulate the cell cycle.
   - Other members of the PRMT family, such as PRMT1 and PRMT6, may have related functions and effects in various signaling pathways.

### Aging and Age-related Diseases

1. **Aging Impact**: PRMT3 has been implicated in cellular processes that decline with age, such as protein synthesis and ribosomal function. Methylation patterns can change with age, potentially altering the activity of various proteins.
  
2. **Age-related Diseases**: Dysregulation of arginine methylation has been connected to several conditions such as:
   - **Neurodegenerative diseases**: Altered PRMT3 activity may influence neuroprotective pathways and could be implicated in diseases like Alzheimer’s disease.
   - **Cancer**: Given its involvement in p53 regulation and other tumor suppressor pathways, aberrant PRMT3 function may contribute to tumorigenesis.
   - **Cardiovascular diseases**: Changes in methylation profiles may affect heart tissues, possibly linking PRMT3 activity to these conditions.

### Drug Interactions

1. **Known Drug Interactions**: While specific drugs targeting PRMT3 directly are not well-established, compounds that inhibit arginine methylation or methyltransferase activity may indirectly affect its function, including:
   - **Histone deacetylase (HDAC) inhibitors**: Some HDACs may influence the expression levels of PRMT enzymes.
   - **Cancer therapeutics**: Certain cancer drugs designed to alter epigenetic markers may also impact PRMT3 expression or activity.
  
2. **Drug Classes**: 
   - **General anti-cancer agents**: Drugs that affect methylation pathways.
   - **Retinoids**: Given PRMT3’s involvement in retinoic acid synthesis, retinoids like all-trans-retinoic acid may be relevant.

### Pathways and Biological Processes

1. **Key Biological Pathways**:
   - **Ribosome biogenesis**: PRMT3 is critical for the maturation of ribosomal components and overall protein synthesis.
   - **Cell cycle regulation**: Linked to pRb and p53 pathways, PRMT3 may influence cell cycle progression and apoptosis.
   - **Retinoic acid signaling**: Inhibition of ALDH1A1 suggests a mechanism through which PRMT3 can regulate retinoic acid availability, impacting developmental and signaling pathways.

2. **Involvement in Biological Processes**:
   - **Methylation processes**: PRMT3 is integral to protein post-translational modification through methylation.
   - **Regulation of gene expression**: By modifying histones and other transcription factors, PRMT3 directly affects gene expression levels.
   - **Response to stress**: Through its regulatory roles, PRMT3 may play a part in cellular stress responses and adaptation.

In conclusion, PRMT3 is an essential gene associated with various biochemical processes, particularly in protein synthesis and modification, and its impacts on aging, disease, and development draw significant attention in research.