### EIPR1 Gene Overview

**Gene Symbol**: EIPR1  
**Location**: Chromosome 2 (though initially associated with the imprinted gene region of 11p15.5)  
**Function**: EIPR1 encodes a protein that is involved in the endosomal retrieval machinery, which is significant for protein transport between endosomes and the trans-Golgi network. It is essential for the recycling of internalized proteins (like the transferrin receptor) and regulates the distribution and secretion of insulin.

### 1. Associated Genes

While the summaries provided do not list them, EIPR1 may have functional associations with other genes involved in endosomal trafficking and signal transduction. Some relevant genes that could be associated with EIPR1 based on literature include:

- **TFRC (Transferrin Receptor)**: Due to its role in recycling activities of EIPR1.
- **GARP (Golgi-Associated Retrograde Protein) subunits**: Since EIPR1 mediates their recruitment to the trans-Golgi network.
- **EARP (Endosome-Associated Recycling Protein) subunits**: As EIPR1 is crucial for the stability and localization of EARP.
  
Additionally, any disruptions in the 11p15.5 region may communicate with tumor-suppressing genes associated with various cancers, although specific genes were not listed in the summary.

### 2. Age-Related Details

While the specific connections of EIPR1 to aging or age-related diseases are not explicitly documented, potential associations can be inferred from its involvement in:

- **Insulin distribution and secretion**: Impairment in insulin signaling and action can be related to aging and diseases such as type 2 diabetes.
- **Cellular transport and recycling processes**: These are generally essential for cellular homeostasis and can influence age-related degeneration, particularly in neurodegenerative diseases.
- **Tumor Suppression**: The association of EIPR1 with the suppression of tumors could relate to cancer risk, which is often age-associated.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes known to interact directly with EIPR1 provided in the summaries. However, drugs that influence endosomal trafficking or insulin signaling may indirectly affect the function or activity of the EIPR1 protein. This could include classes like:

- **Insulin Sensitizers (e.g., Metformin)**: These may influence overall insulin signaling and boy's trophic functions where EIPR1 is a player.
- **Antineoplastic Agents**: As EIPR1 is associated with tumors, certain anticancer drugs may have interactions or modulatory effects related to its function.

### 4. Pathways and Biological Processes

The EIPR1 gene is involved in several critical pathways and biological processes, including:

- **Endosomal Transport**: Engaging in pathways that manage protein sorting and trafficking between endosomes to Golgi networks and plasma membranes.
- **Insulin Signaling Pathway**: Essential for maintaining normal secretion and distribution of insulin, impacting glucose homeostasis.
- **Recycling Pathway**: Regulates the recycling of endosomal compartments, crucial for retaining cell surface receptors and cargo.

#### Summary

EIPR1 is a critical gene for cellular transport processes involving proteins, specifically in endosomal and Golgi trafficking and insulin management. Its implications in tumor suppression, potential links to age-related diseases, and indirect interactions through insulin and trafficking pathways offer a foundation for future research into this gene's broader impact on health and disease.