### MARCKSL1 Gene Overview

**Gene Symbol:** MARCKSL1  
**Location:** Human chromosome 1p31.3  
**Protein:** Member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family, involved in cytoskeletal regulation and signaling pathways.

### 1. Associated Genes
While the NCBI and UniProt summaries do not specify a list of associated genes, MARCKSL1 has been linked to several other genes involved in cytoskeletal dynamics and signal transduction. Some of these include:
- **MARCKS:** Another member of the same family, which is crucial for actin filament dynamics.
- **PKC family genes (e.g., PRKCA, PRKCB):** Since MARCKSL1 interacts with protein kinase C signaling pathways.
- **CALM1:** The calmodulin gene, as MARCKSL1 is involved in calmodulin signaling.
- **RHOA:** A gene involved in actin cytoskeletal reorganization.

### 2. Aging and Age-related Diseases
As of the last updates in 2023, there have been hints that MARCKSL1 may play a role in aging and age-related diseases, although specific studies may be limited. Known associations include:
- **Neuronal migration:** Altered MARCKSL1 expression might impact neuronal functions, potentially contributing to neurodegenerative diseases, which are often age-related.
- **Cancer:** Changes in the phosphorylation state of MARCKSL1 and its role in regulating cell migration may link it to age-related cancers.

### 3. Known Drug Interactions
At present, specific drugs directly interacting with MARCKSL1 are not widely documented. However, given its role in signaling pathways, it could potentially be implicated in pharmacological responses to:
- **Protein Kinase C inhibitors:** Drugs such as Go6976, which inhibit PKC, might affect MARCKSL1 activity.
- **Calmodulin blockers:** Such as W-7, which may indirectly affect MARCKSL1 due to its involvement in calmodulin signaling.
- **Compounds targeting downstream effects in cytoskeletal dynamics:** Such as Rho inhibitors may interact indirectly with the pathways MARCKSL1 is part of.

### 4. Biological Pathways and Processes
MARCKSL1 is involved in multiple biological processes and signaling pathways:
- **Actin Cytoskeleton Regulation:** Essential for proper cell shape, adhesion, and motility.
- **Cell Migration:** Induces and regulates cell motility through the modulation of actin structure.
- **Signal Transduction:** Functions in protein kinase C and calmodulin signaling pathways pertinent to various cellular responses.
- **Formation of Adherens Junctions:** Implicated in cell-cell adhesion processes, which are critical for tissue integrity and structure.
- **Neuronal Development:** Possible roles in neuronal cell signaling and migration processes.

### Conclusion
MARCKSL1 is a multifunctional gene with significant implications in cytoskeletal dynamics, cell migration, and signal transduction pathways. Its potential associations with aging, neurodegenerative diseases, and cancer highlight its importance in various biological contexts. Although direct therapeutic interactions are not explicitly documented, understanding MARCKSL1's role may offer insight into potential interventions targeting these pathways.