### CDC23 Gene Overview

**Gene Symbol:** CDC23  
**Function:** The CDC23 gene encodes a protein that is an essential component of the anaphase-promoting complex/cyclosome (APC/C). This complex functions as a cell cycle-regulated E3 ubiquitin ligase, playing a pivotal role in controlling the progression of cells through mitosis and the G1 phase of the cell cycle. By facilitating the ubiquitination and subsequent degradation of various cell cycle regulators, the CDC23 protein contributes to the precise orchestration of cell division.

### Additional Information:

1. **Associated Genes:**  
   The CDC23 gene is associated with other genes encoding subunits of the anaphase-promoting complex, including:
   - **CDC16**
   - **CDC20**
   - **CDC27**
   - **CDC26**
   - **APC4 (also known as APC7)**
   - Numerous cyclin genes (e.g., cyclin B1 and cyclin A) that are targeted for degradation during cell cycle regulation.
   - Genes involved in the regulation of cell cycle checkpoints such as **CHK1** and **TP53**.

2. **Aging and Age-Related Diseases:**  
   Although specific studies directly linking CDC23 to aging or age-related diseases are limited, misregulation of the APC/C complex, of which CDC23 is a critical component, has been implicated in various age-related diseases, particularly cancer. As cells age, the accumulation of defective proteins and the failure to degrade damaged cell cycle regulators can lead to genomic instability and uncontrolled cell proliferation. Thus, while CDC23 may not have direct associations with specific age-related conditions, its functional role in maintaining cell cycle integrity implies that it may play an indirect role in aging and associated pathologies.

3. **Interactions with Drugs or Drug Classes:**  
   While specific drug interactions targeting CDC23 might not be well-characterized, potential drug classes that could influence the activity of the anaphase-promoting complex include:
   - **Proteasome inhibitors (e.g., Bortezomib, Carfilzomib):** These drugs target the proteasome, involved in protein degradation pathways that the APC complex collaborates with.
   - **Antineoplastic agents:** Some cancer treatments may target cell cycle progression and could impact the function of the APC/C complex indirectly.

4. **Pathways and Biological Processes:**
   The CDC23 gene is involved in several key biological pathways and processes:
   - **Cell Cycle Regulation:** Key player in the transition from metaphase to anaphase during mitosis.
   - **Ubiquitin-mediated Proteolysis:** It contributes to the ubiquitination and degradation of proteins, particularly cyclins, which are essential for the orderly progression of the cell cycle.
   - **Mitotic Nuclear Division:** Participates in the regulation of chromosomal segregation.
   - **G1/S Transition and G2/M Transition:** Regulates checkpoints that prevent the cell from progressing if DNA is damaged or improperly replicated.

This detailed overview of the CDC23 gene encompasses its function, associated genes, implications in aging and disease, drug interactions, and involvement in critical biological pathways, illustrating its importance in cellular regulation.