### FKBP1C Gene Overview

**Gene Symbol:** FKBP1C  
**Function:** The FKBP1C gene encodes a member of the FK506-binding protein (FKBP) family of immunophilins, which are characterized by their peptidyl-prolyl cis-trans isomerase (PPIase) activity. This protein contributes to protein folding and chaperoning through cis-trans isomerization of peptidyl proline bonds in polypeptides, thus facilitating the proper folding of proteins within the cytoplasm.

### 1. Associated Genes
FKBP1C is linked to several other genes and gene families due to its role in protein folding and chaperoning. Some notable associated genes include:
- **FKBP1A** and **FKBP1B**: Other members of the FKBP family that share functional similarities and may have overlapping functions in immunophilins' activities.
- **HSP90AA1**: Heat shock protein 90, involved in protein folding and stabilization, often acting in conjunction with FKBPs.
- **GRP94**: A glucose-regulated protein that acts as a chaperone, also associated with FKBP functions.

### 2. Aging and Age-Related Diseases
Research suggests that FKBP1C may play a role in several age-related processes and diseases:
- **Ageing:** FKBP proteins have been implicated in the regulation of cellular stress responses and the maintenance of proteostasis, which are crucial for cellular health in aging organisms.
- **Neurodegenerative Diseases:** Dysregulation of protein folding and degradation pathways involving FKBP1C may contribute to conditions such as Alzheimer's disease, where protein aggregation is a hallmark.
- **Cardiovascular Diseases:** Altered expression of FKBP1C has been linked to cardiac hypertrophy and other cardiovascular complications in aging populations.

### 3. Drug Interactions
FKBP1C interacts with various drugs and drug classes, notably:
- **Immunosuppressants:** FK506 (Tacrolimus) and Cyclosporine, which target FKBP proteins to inhibit immune responses, particularly in organ transplantation settings.
- **Width Spectrum of FK506-binding Ligands:** These include a range of compounds that can modulate FKBP activity or interact with chaperone mechanisms.
- **Potential Drug Candidates:** Other small molecules targeting FKBP and its pathways for neurodegenerative diseases and cancer therapy are under investigation.

### 4. Pathways and Biological Processes
FKBP1C is involved in several critical biological pathways and processes, including:
- **Protein Folding and Chaperone Pathways:** It assists in proper protein conformation and protection against misfolded proteins.
- **Signaling Pathways:** FKBP1C is known to modulate signaling pathways such as those involving glucocorticoids by binding to steroid receptors.
- **Cell Cycle Regulation:** Influence through protein interaction can modulate various cell cycle mechanisms, potentially affecting proliferation.
- **Stress Response Mechanisms:** It plays a role in cellular responses to stress, particularly in protein quality control systems, ensuring functional protein synthesis even under adverse conditions.

### Summary
The FKBP1C gene plays a crucial role in protein folding and cellular stress responses with implications in genuine biological processes associated with aging and various diseases. Its interactions with drugs and other proteins render it significant in therapeutic contexts. Ongoing research is expected to further elucidate its diverse roles in health and disease.