### PRKD3 Gene Overview

**Gene Symbol:** PRKD3  
**Location:** Chromosome 19  
**Protein Coding:** Yes  
**Protein Name:** Protein Kinase D3  

#### 1. Associated Genes
While the summaries provided do not explicitly list associated genes, PRKD3 functions as part of signaling pathways that often involve several other genes, particularly those linked to cellular responses and regulation. Some associated genes include:

- **PRKD1** and **PRKD2**: Other members of the protein kinase D family which share functional roles in various signaling pathways.
- **AKT1**: Involved in pathways that intersect with PRKD3 in regulating growth and survival of cells.
- **RHOA**: A small GTPase that interacts with PRKD family members in various cellular functions.

#### 2. Aging or Age-Related Diseases
PRKD3 is implicated in cellular processes that can influence aging and age-related diseases, particularly due to its role in cell growth and survival, as well as its involvement in cancer. Some specifics include:

- **Cancer:** Its regulation of proliferation and apoptosis places it in the context of age-associated cancer risks. Dysregulation of PRKD3's activity may contribute to age-related tumorigenesis in tissues such as breast and prostate.
- **Cellular Aging:** The kinase's function in vesicle trafficking and cellular signaling could affect processes like cellular senescence, which is pivotal in the aging process.

#### 3. Drug Interactions
Currently, specific drug interactions directly with the PRKD3 gene are not extensively characterized. However, general classes of pharmacological agents that may affect pathways involving PRKD3 include:

- **Phorbol Esters:** These compounds, which mimic diacylglycerol, activate protein kinase D pathways.
- **Selective Serotonin Reuptake Inhibitors (SSRIs):** Some studies suggest SSRI influence on the phosphoinositide signaling pathways where PKD family members, including PRKD3, can play a role.

#### 4. Pathways and Biological Processes
PRKD3 is involved in various biological processes and cellular pathways:

- **Signal Transduction:** Regulates signaling pathways downstream of diacylglycerol and protein kinase C (PKC).
- **Cell Proliferation:** Plays a role in the growth regulation of epithelial cells, as well as cancer cells in breast and prostate cancer.
- **Vesicle Trafficking:** Involved in the intracellular transport mechanisms, essential for cellular communication and function.
- **Response to Oxidative Stress:** Implicated in mechanisms that help cells cope with oxidative damage, contributing to cellular resilience, especially relevant in aging and longevity studies.

### Summary
PRKD3 is a critical member of the protein kinase D family that integrates various signaling cues within cells, linking them to cancer biology, cellular stress responses, and possibly the aging process. Further research may clarify its interactions with specific drugs and refine the understanding of its role in age-related diseases.