### CBLL1 Gene Overview

**Gene Symbol:** CBLL1  
**Location:** Human chromosome (specific location variant)  
**Gene Type:** Protein-coding  

**Function:** The CBLL1 gene encodes an E3 ubiquitin ligase that plays a critical role in mediating the ubiquitination of various proteins, particularly components of the E-cadherin complex. This function is crucial for the endocytosis and subsequent degradation of E-cadherin, a protein vital for cell-cell adhesion. Additionally, CBLL1 is thought to participate in regulating cell proliferation and is associated with the WMM complex, which is involved in RNA methylation processes.

### Additional Associations

1. **Related Genes:**
   - **CDH1 (E-cadherin):** Critical substrate for CBLL1-mediated ubiquitination.
   - **CTTN (Cortactin):** Another substrate implicated in cytoskeletal dynamics.
   - **DOK1 (Docking protein 1):** May also be targeted for ubiquitination by CBLL1.
   - **Pseudogene on chromosome X:** Related but non-functional sequence.

2. **Aging and Age-Related Diseases:**
   - While specific studies on CBLL1 directly linking it to aging or age-related diseases may be limited, its role in regulating cell proliferation and the endocytosis of cell adhesion molecules could implicate it in processes associated with aging, such as tissue remodeling, cancer progression, and degenerative diseases. Hormonal changes during aging may alter E-cadherin dynamics, potentially affecting cellular adhesion and tissue integrity.

3. **Drug Interactions:**
   - Currently, there is limited specific data on drugs that directly target or interact with CBLL1. However, compounds influencing ubiquitin-proteasome pathways, including proteasome inhibitors (like Bortezomib), might indirectly affect the activity of E3 ubiquitin ligases, including CBLL1.
   - Potential exploration of compounds that modulate cell adhesion or E-cadherin interactions could also provide insights into therapeutic avenues involving CBLL1.

4. **Pathways and Biological Processes:**
   - **Ubiquitin-mediated proteolysis:** CBLL1 is directly involved in the ubiquitin-proteasome system, which regulates protein degradation.
   - **Cell adhesion:** Modulates the stability and degradation of E-cadherin, affecting cellular adhesion and signaling.
   - **Cell proliferation:** Implicated in the regulation of cell cycle dynamics, which may relate to tumorigenesis.
   - **mRNA methylation:** Associated with the WMM complex, influencing the methylation of N6-methyladenosine (m6A) on RNA, which has implications for mRNA splicing and processing.
  
It's essential to continue investigating the specific roles of CBLL1 in various cellular contexts, aging-related mechanisms, and its potential as a drug target in disease states.