**SEMA6A-AS2 Gene Summary**

SEMA6A-AS2, known as SEMA6A antisense RNA 2, is classified as a long non-coding RNA (lncRNA). It is located on chromosome 1 and is considered an antisense transcript of the SEMA6A gene, which encodes a member of the semaphorin family of axon guidance cues. The SEMA6A gene plays a significant role in neural development and processes related to the nervous system.

### 1. Associated Genes
Beyond SEMA6A, SEMA6A-AS2 may also be associated with other genes that are involved in neural development and guidance, such as:
- **SEMA3A**: Another semaphorin involved in axon guidance.
- **NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1)**: Known for its role in neurotrophin signaling for neuronal differentiation and survival.
- **PLXNA1 (Plexin A1)**: A receptor for semaphorins that contribute to axon guidance and neural cell migration.

### 2. Aging and Age-Related Diseases
While specific studies directly linking SEMA6A-AS2 to aging are limited, the SEMA6A gene has been implicated in neurodevelopmental disorders and neurodegenerative diseases, including:
- Alzheimer’s disease: Alterations in semaphorin signaling pathways can affect neuronal survival and lead to neurodegeneration.
- Other potential associations may involve cognitive decline related to aging, primarily due to the gene's function in neuronal pathways.

### 3. Drug Interactions
There are currently no specific drugs or drug classes that are well-documented to target SEMA6A-AS2 directly. However, modulators of neurotrophic signaling pathways may indirectly influence the expression or function associated with SEMA6A and its antisense counterpart. Future studies may reveal drugs that impact this lncRNA indirectly through their broader effects on the nervous system.

### 4. Pathways and Biological Processes
SEMA6A-AS2 is involved in:
- **Neuron projection development**: Regulating the growth and branching of neuronal projections, which is crucial during development.
- **Semaphorin signaling pathway**: Participating in signaling mechanisms that control cell migration and axon guidance during neural development.
- **Regulation of gene expression**: As an lncRNA, SEMA6A-AS2 may play a role in gene regulation, either by interacting with chromatin or other RNA molecules, influencing neuronal gene networks.

In summary, SEMA6A-AS2 serves as a regulator in neurodevelopmental processes and may have implications in age-related neurodegenerative diseases, although more research is needed to fully understand its role and potential therapeutic targets.