The NQO1-DT gene, or NQO1 divergent transcript, is a relatively recently characterized gene situated adjacent to the NQO1 gene, which encodes for the enzyme NAD(P)H dehydrogenase (quinone), an important player in cellular antioxidant defense. Below is a detailed overview of the NQO1-DT gene, including additional information as requested.

### General Gene Information:
- **Gene Symbol**: NQO1-DT
- **Location**: It is located on chromosome 16, close to the NQO1 gene.

### 1. Associated Genes:
NQO1-DT is primarily associated with the NQO1 gene itself. However, as it is a divergent transcript, it may have interactions or regulatory roles in relation to genes involved in oxidative stress responses or metabolic pathways. Some listed genes associated with NQO1 include:
- **NQO1**: Directly, as it is located near the NQO1-DT gene.
- Other genes involved in the antioxidant response, including:
  - **GSR** (Glutathione Reductase)
  - **SOD** (Superoxide Dismutase)
  - **CAT** (Catalase)  
Note that direct associations may depend on specific biological contexts or studies.

### 2. Aging and Age-Related Diseases:
NQO1 and its related transcripts have been studied in the context of oxidative stress, which is implicated in aging and related diseases. 

- **Oxidative Stress**: The NQO1 enzyme contributes to the detoxification of reactive oxygen species (ROS), and its deficiency has been associated with increased oxidative damage and susceptibility to age-related diseases.
- **Age-Related Diseases**: There is potential involvement in conditions such as cancer, neurodegenerative diseases (e.g., Alzheimer’s and Parkinson’s), and cardiovascular diseases where oxidative stress plays a significant role.
- **Longevity Studies**: Variants associated with NQO1 may provide insights into longevity and the resilience of certain populations to age-related diseases.

### 3. Drug Interactions:
While specific interactions with drugs for NQO1-DT may not be well-documented due to its emerging characterization, the NQO1 enzyme, which NQO1-DT is associated with, interacts with several compounds. Some examples include:
- **Antioxidants** like **Coenzyme Q10** (ubiquinone), which boosts the function of NQO1.
- **Chemotherapeutics** such as **Doxorubicin**, which is bioactivated by NQO1 and may influence its expression through feedback mechanisms.
- **Nutraceuticals** including **Curcumin**, known to induce NQO1 activity.

### 4. Pathways and Biological Processes:
NQO1-DT is involved in various biological pathways primarily related to detoxification, antioxidant activity, and stress responses. Relevant pathways include:
- **NADPH Regeneration**: Involves the maintenance of cellular redox state.
- **Detoxification of Quinones**: Protects against toxic compounds formed during metabolism.
- **Cellular Response to Oxidative Stress**: Via NQO1, contributing to the overall balance of antioxidants in the cell.

### Summary:
In summary, NQO1-DT appears to play a role in cellular responses to oxidative stress, with implications for aging and age-related diseases. It is associated with genes involved in antioxidant defense, and while specific drug interactions for NQO1-DT are limited, the nearby NQO1 gene interacts with various pharmacological agents. The biological pathways associated emphasize the importance of maintaining cellular health, particularly in the context of stress responses. As research continues, a clearer understanding of the NQO1-DT gene and its functional significance will likely emerge.