### PPIAP83 Gene Overview

**Gene Symbol:** PPIAP83  
**Alternative Names:** PPIAP83 is often referenced in relation to other terms in the literature, although specific synonyms may not be prominent.

PPIAP83 is a member of the peptidylprolyl isomerase family, which plays roles in protein folding and isomerization. It may be involved in various cellular and physiological processes, including those related to cell cycle regulation, cancer proliferation, and other cellular stress responses.

#### 1. Associated Genes
While the specific NCBI and UniProt summaries may not list associated genes, the PPIAP83 gene may interact with or have functional relationships with several other genes involved in cellular stress responses, cell cycle control, and possibly oncogenic pathways. Possible associated genes may include:

- **PPIA (Peptidylprolyl Isomerase A):** Functions similarly in protein folding.
- **CDK (Cyclin-dependent Kinases):** Plays a crucial role in cell cycle regulation, potentially interacting with PPIAP83.
- **HSPs (Heat Shock Proteins):** Assist in protein folding; involvement in stress responses may provide indirect association with PPIAP83.

#### 2. Aging and Age-related Diseases
While specific studies directly linking PPIAP83 to aging or age-related diseases may be limited, genes in the peptidylprolyl isomerase family often play roles in enhancing or mitigating the rate of cellular aging, primarily through their influence on protein structure and function. Impairments in these processes can lead to age-related degeneration and diseases such as:

- **Neurodegenerative diseases:** Such as Alzheimer’s or Parkinson’s disease, where protein misfolding and aggregation are common.
- **Cancer:** Altered expression or function of PPIAP83 can influence tumorigenesis or cancer cell proliferation, which is also related to aging.

Further research would be necessary to clarify any specific associations of PPIAP83 with these conditions directly.

#### 3. Drug Interactions
Specific drugs or drug classes that target or interact with PPIAP83 may not yet be well-defined in literature, but:

- **Immunosuppressants:** Since some peptidylprolyl isomerases are involved in T-cell activation (e.g., FK506 or Cyclosporin A), there may be effects on PPIAP83 function indirectly via T-cell responses.
- **Anticancer drugs:** As PPIAP83 may play a role in cancer biology, certain chemotherapeutic agents aimed at pathways involving cell proliferation may interact indirectly.

Continued research might elucidate more formal drug interactions or the development of PPIAP83-specific modulating agents.

#### 4. Pathways and Biological Processes
PPIAP83 is involved in several key biological processes and cellular pathways, including but not limited to:

- **Protein Folding and Isomerization:** Facilitates the correct folding of proteins and reduces misfolding, a crucial function of peptidylprolyl isomerases.
- **Cell Cycle Regulation:** It may act on regulators of the cell cycle, affecting cell proliferation and growth.
- **Response to Stress:** Participates in the cellular response mechanisms to various stress signals, potentially contributing to cell survival under adverse conditions.
- **Signal Transduction Pathways:** Given its role in protein interaction and modification, it could be involved in pathways such as the MAPK signaling or NF-kB pathways, which are essential for various cellular responses.

Further research may expand on these processes and demonstrate more intricate pathways involving PPIAP83.

### Conclusion
The PPIAP83 gene holds importance in protein folding and cellular regulation with implications in aging and disease processes. Future studies will enhance the understanding of its interactions with other genes, associations with age-related diseases, drug interactions, and involvement in biological pathways. 

For comprehensive insights, it is recommended to refer to ongoing literature and databases for the most current findings.