### RNU6-990P Gene Overview

**Gene Symbol**: RNU6-990P  
**Gene Type**: Non-coding RNA (specifically a small nuclear RNA or snRNA)  
**Function**: RNU6-990P is implicated in the splicing of pre-mRNA, which is a fundamental process in gene expression regulation. This gene is part of the U6 small nuclear RNA family, which plays a critical role in the spliceosome, the molecular machine responsible for RNA splicing.

### Associated Genes
While the summaries from NCBI and UniProt do not specify associated genes, small nuclear RNAs typically interact with various proteins involved in splicing and other RNA processing activities. Some examples of genes potentially associated or involved in similar splicing processes include:
- **SNRNPs (Small Nuclear Ribonucleoproteins)**: These are components of the spliceosome and include various SNRNP subunits like U1, U2, U4, U5, and U6.
- **PRPFs (Pre-mRNA Processing Factors)**: Genes such as PRPF8 and PRPF31 are involved in spliceosomal assembly and function.

### Aging and Age-Related Diseases
1. **Aging**: Changes in RNA splicing mechanisms, including those involving snRNA such as RNU6-990P, have been implicated in the aging process. For example, altered expression of splicing factors has been shown to affect RNA splicing patterns with age.
   
2. **Age-Related Diseases**: Abnormalities in RNA splicing are often associated with various age-related diseases, including:
   - **Neurodegenerative diseases**: Aberrant splicing is linked with conditions like Alzheimer's and Amyotrophic Lateral Sclerosis (ALS).
   - **Cancer**: Altered splicing can lead to the production of oncogenic proteins or the loss of tumor suppressors, making it relevant for various cancers, particularly as they are often age-associated.

### Drug Interactions
Currently, there are no specific drugs or drug classes directly known to interact with RNU6-990P. However, compounds that modify RNA splicing, such as **antisense oligonucleotides** or small molecules that affect spliceosome function, may indirectly impact the expression or function of this gene.

### Pathways and Biological Processes
RNU6-990P is primarily associated with:
1. **RNA Splicing**: It plays a critical role in the spliceosome assembly and function.
2. **RNA Processing**: This includes alternative splicing mechanisms, which allow for complex regulation of gene expression.
3. **mRNA Metabolism**: RNU6-990P contributes to the maturation of messenger RNAs (mRNAs).
4. **Small Nuclear RNA (snRNA) Processing**: As a member of the snRNA family, it participates in the biogenesis and regulation of other non-coding RNAs.

### Summary
RNU6-990P is an essential non-coding RNA that participates in the RNA splicing process critical for gene expression. While not directly associated with drugs, it plays a role in significant biological processes associated with aging and pathologies, particularly those related to RNA splicing dysregulation.