### SNORA80D Gene Overview

**Gene Symbol**: SNORA80D

The SNORA80D gene is a small nucleolar RNA (snoRNA) gene belonging to the class of C/D box snoRNAs. These types of snoRNAs are primarily involved in the modification and processing of ribosomal RNA (rRNA) and other small nuclear RNAs (snRNAs). Specifically, they guide the methylation of target RNAs by directing specific methyltransferases to the rRNA or other RNA substrates.

#### 1. Associated Genes
While SNORA80D is primarily known for its role in rRNA processing, specific associations with other genes may not be widely characterized due to the nature of snoRNA functions being often indirect and tied to broader pathways rather than direct interactions. However, like other snoRNAs, it could be functionally related to:

- **RMTs (RNA Methyltransferases)**: Such as FBL (fibrillarin), a key enzyme involved in the methylation modifications of rRNA.
- **Other C/D Box snoRNAs**: SNORDs, which also participate in rRNA processing and modification.

Further interactions may emerge from high-throughput studies or co-expression networks, which often identify interactions within ribosome biogenesis pathways.

#### 2. Aging and Age-Related Diseases
While specific details linking SNORA80D directly to aging or age-related diseases are limited, small nucleolar RNAs, in general, have been implicated in the regulation of ribosome biogenesis and cellular homeostasis, which can have downstream effects on cellular aging processes. Dysregulation of nucleolar function and ribosomal RNA modification has been associated with:

- **Cancer**: Altered snoRNA expression profiles often correlate with tumorigenesis and cancer progression.
- **Age-related cognitive decline**: Some studies note that changes in snoRNA expression patterns may reflect neurological conditions related to aging.

Further research would be needed to establish a direct role for SNORA80D in these processes.

#### 3. Drug Interactions
As of now, there is no established direct interaction for drugs specifically targeting SNORA80D. However, potential indirect interactions may exist through pathways influenced by nucleolar functions or ribosomal biogenesis. Certain anticancer drugs that impact cellular machinery could indirectly affect the expression or function of snoRNAs, including SNORA80D.

There may also be a prevailing interest in small molecules or biomolecules that modulate snoRNA functions more broadly, although specific drugs targeting SNORA80D specifically are currently under-explored.

#### 4. Involved Pathways and Biological Processes
SNORA80D is primarily involved in:

- **Ribosome biogenesis**: As a snoRNA, SNORA80D is involved in the methylation and processing of rRNA, which is crucial for the formation of functional ribosomes.
- **Modification of rRNA**: Specifically, it plays a role in the 2’-O-ribose methylation of rRNA, which is essential for ribosomal function and cellular protein synthesis.

Additional pathways involving SNORA80D may include those related to:

- **Cellular stress responses**
- **Apoptosis and cell cycle regulation**: Given its association with rRNA synthesis and ribosomal assembly.

In summary, while the SNORA80D gene primarily serves in ribosomal RNA processing, its implications in aging and disease, genetic associations, and drug interactions merit further investigation for a comprehensive understanding. Ongoing research into small nucleolar RNAs may uncover more profound roles in cellular processes and disease mechanisms.