**Gene Overview: KMT5AP3**

The KMT5AP3 gene encodes a protein known as lysine-specific methyltransferase 5A-interacting protein 3, which is implicated in various biological processes, predominantly in gene regulation through histone methylation modification. The protein is involved in the chromatin remodeling and transcriptional regulation mechanisms that influence gene expression and cellular behavior.

### 1. Associated Genes:
While direct associations with specific genes may vary in different studies, KMT5AP3 has been explored in the context of various regulatory networks. Potentially related genes might include:

- **KMT5A (also known as SETD1A)**: As KMT5AP3 interacts with this protein, the involvement of KMT5A in histone modification might suggest regulatory pathways.
- **Other histone methyltransferases**: Genes that are involved in chromatin remodeling and histone modification processes, including, but not limited to, **SETD2**, **SETDB1**, and **EZH2**.
  
This list is not exhaustive and thorough literature searches could yield additional interacting or associated genes.

### 2. Aging and Age-Related Diseases:
Specific research directly linking KMT5AP3 to aging or age-related diseases is limited. Still, given its involvement in transcriptional regulation and chromatin dynamics, alterations in KMT5AP3 expression or function could potentially affect cellular senescence pathways, epigenetic aging processes, or age-associated diseases such as:

- **Cancer**: Dysregulation of methyltransferases, including those related to KMT5AP3, can be a hallmark of tumorigenesis.
- **Neurodegenerative diseases**: Epigenetic changes are crucial in the progression of neurodegenerative disorders, making KMT5AP3 a target for future studies.

### 3. Drug Interactions:
As of my last update, specific drugs or drug classes directly interacting with KMT5AP3 have not been conclusively established in available literature. However, due to its enzymatic role in histone methylation, compounds known as **histone methyltransferase inhibitors** (e.g., small molecule inhibitors targeting SET domain proteins) may have downstream effects on KMT5AP3 activity indirectly. Targeted pharmacological approaches that modify the expression or function of KMT5A and other histone methyltransferases may also impact KMT5AP3.

### 4. Pathways and Biological Processes:
**KMT5AP3** is involved in various cellular processes, including:

- **Chromatin remodeling**: KMT5AP3 plays a role in modifying chromatin structure, thereby influencing gene accessibility and transcription.
- **Transcription regulation**: This gene is implicated in the regulation of transcription via histone methylation, impacting both gene activation and repression.
- **Cell cycle regulation**: Through its interaction with other proteins and complexes, it may regulate mechanisms necessary for orderly cell cycle progression.
  
Other pathways potentially influenced by KMT5AP3 may relate to epigenetic modifications and DNA repair pathways, though more specific studies would be necessary to outline these associations distinctly.

### Conclusion:
KMT5AP3 is an important player in the regulation of gene expression through chromatin modification. While there is potential for this gene to be connected to aging and various diseases, further research is needed for detailed understanding and characterization. The impact of drugs targeting epigenetic regulators on KMT5AP3 remains an area ripe for exploration, particularly regarding cancer and other age-related pathologies.