### SNORD116-21 Gene Overview

**Gene Symbol**: SNORD116-21  
**Location**: The SNORD116 gene family is located on chromosome 15 (15q11.2) and is known to be implicated in the genetic disorder Prader-Willi syndrome (PWS).

### 1. Associated Genes
SNORD116-21 is part of the SNORD116 gene cluster. Other genes that are genetically associated with SNORD116 or located nearby include:

- **SNORD116-15**
- **SNORD116-26**
- **SNORD116-29**

In a broader context, it may be indirectly associated with genes involved in Prader-Willi syndrome and those pertinent to the imprinted gene region on chromosome 15, including:

- **SNRPN** (Small Nuclear Riboprotein Polypeptide N)
- **MAGEL2** (MAGE-Like 2)
- **NECDIN** (Necdin)
- **MKRN3** (Makorin Ring Finger 3)

### 2. Aging and Age-Related Diseases
While specific studies directly linking SNORD116-21 to aging or age-related diseases are limited, the gene's association with Prader-Willi syndrome, which leads to developmental challenges, obesity, and endocrine abnormalities, suggests potential implications in metabolic aging and health span. Disruptions in the regulation of SNORD116 have been linked to neurodevelopmental and metabolic disorders, which can also have aging-related consequences. Furthermore, the role of snoRNAs, such as SNORD116, in gene regulation can influence cellular senescence pathways and RNA processing related to aging.

### 3. Drug Interactions
As of October 2023, there are no specific drugs or drug classes explicitly reported to interact with SNORD116-21. However, given its role as a snoRNA, any investigation into therapeutic interventions related to Prader-Willi syndrome or associated metabolic disorders might reveal indirect relationships.

### 4. Pathways and Biological Processes
SNORD116-21 is involved in:

- **RNA Biogenesis**: As a member of the small nucleolar RNA (snoRNA) family, SNORD116-21 is involved in the chemical modification of other RNAs, particularly in the methylation of ribosomal RNA (rRNA).

- **Gene Expression Regulation**: SnoRNAs play roles in the regulation of gene expression, influencing various biological processes through the modification of RNA molecules, impacting how genes are transcribed and translated.

- **Cell Cycle and Development**: The gene's association with developmental syndromes such as Prader-Willi syndrome links it to pathways involved in growth regulation and normal development.

Overall, while the SNORD116-21 gene is primarily recognized for its role within the snoRNA family and its connection to specific syndromic conditions,there is ongoing research to elucidate its broader functionalities, particularly as they relate to development and potential implications in age-related processes.