### RNA5SP464 Gene Overview

**Gene Symbol:** RNA5SP464  
**Gene Type:** RNA (non-coding) gene, specifically a small nucleolar RNA (snoRNA).  

**Function:** RNA5SP464 is primarily involved in the post-transcriptional modification of other RNAs, particularly in the methylation of ribosomal RNAs (rRNAs) and small nuclear RNAs. This modification is crucial for the stability and functionality of these RNAs within the ribosomal subunits.

### 1. Associated Genes

While specific gene associations may not be thoroughly documented for RNA5SP464, snoRNAs like this often cluster with other snoRNA genes and are frequently found in the vicinity of genes encoding ribosomal proteins. Here are potential associated genes:

- **RPS12**: A gene encoding ribosomal protein S12, which may be co-regulated with snoRNA genes.
- **RPL genes**: Including RPL7, RPL8, RPL37, which encode ribosomal proteins that interact with rRNA.

### 2. Aging and Age-related Diseases

As of the current knowledge, the specific connection of RNA5SP464 to aging or age-related diseases remains limited. However, snoRNAs and their functions in RNA processing and ribosome maturation can indirectly influence cellular processes associated with aging and may play a role in conditions like cancer or neurodegenerative diseases. Aberrant expression of snoRNA genes has been observed in certain age-related pathologies, suggesting a potential, albeit not directly documented, association with aging.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes reported to directly interact with RNA5SP464. However, therapeutic agents affecting RNA processing or targeting ribosome biogenesis could feasibly influence the gene's associated pathways.

### 4. Pathways and Biological Processes

RNA5SP464 participates in several biological processes and signaling pathways, often in combination with other snoRNAs, including:

- **RNA Methylation**: RNA5SP464 is involved in the methylation of rRNA, aiding in the formation of the mature ribosomal subunits.
- **Ribosome Biogenesis**: It plays a role in the assembly and maturation of ribosomes, which is critical for protein synthesis.
- **Nuclear RNA Processing**: It contributes to various aspects of RNA processing within the nucleolus, primarily associated with rRNA.

Specific pathways might involve Ribosome biogenesis in eukaryotes or the overall synthesis and maturation of rRNA precursors, but precise pathways directly linked to RNA5SP464 may require further experimental validation.

### Conclusion

RNA5SP464 is a small nucleolar RNA likely involved in ribosomal RNA modification and ribosome biogenesis, with potential indirect implications for aging and diseases through its role in cellular processes. The current data and literature do not strongly emphasize direct drug interactions or specific associated genes but highlight the gene's foundational role in RNA biology. Further research may clarify its broader implications in cellular and disease contexts.