### CEP135 Gene Overview

**Gene Symbol:** CEP135  
**Location:** Chromosome 10  
**Gene Description:** The CEP135 gene encodes a centrosomal protein that plays a crucial role in centriole biogenesis. It is involved in the structural organization and cohesion of centrioles during interphase, functioning as a scaffolding protein essential for the assembly of other proteins at the centrosomes.

#### 1. Other Gene Associations 
Beyond the proteins mentioned in the summaries, CEP135 is associated with several other genes/proteins involved in centrosomal and ciliary functions, including:
- **PLK4**: A serine/threonine-protein kinase that is integral for centriole biogenesis.
- **CEP295**: A protein that localizes to centrioles and is involved in their duplication.
- **PCM1**: A scaffold protein that forms part of the centrosome and is important for organizing proteins there.
- **SSX2IP**: A protein involved in centriole assembly and stability.
- **CEP290**: A protein known to be involved in the structure and function of cilia and centrosomes.

#### 2. Aging and Age-Related Diseases
The role of CEP135 in centriole cohesion and organelle regulation suggests a potential association with aged-related cellular functions. While not explicitly linked to aging in existing literature, centrosomal dysfunction has been implicated in age-related diseases, including:
- **Neurodegenerative disorders**: As with primary microcephaly, centrosomal defects can lead to issues in neural development and maintenance.
- **Cancer**: Abnormal centriole number and function could contribute to chromosomal instability commonly seen in cancer cells.

Research into the specific role of CEP135 in aging or age-related diseases remains an emerging field.

#### 3. Drug Interactions
Currently, there are no specific drugs or drug classes widely recognized to interact directly with CEP135. However, as it is involved in centriole biogenesis and stability, potential investigational drugs targeting cellular processes such as:
- **Microtubule inhibitors** (e.g., taxanes or vinca alkaloids) may indirectly affect centriole function through their effects on the microtubular network.
- **PLK4 inhibitors**: Given the dependence of CEP135's recruitment function on PLK4 during early S phase, inhibitors of PLK4 could be relevant in studies related to CEP135.

#### 4. Pathways and Biological Processes
CEP135 is involved in several critical cellular pathways and processes:
- **Centrosome Cycle**: Functions in the biogenesis and duplication of centrioles during the cell cycle.
- **Centriole Cohesion**: Ensures structural integrity and cohesion of centrioles during interphase.
- **Microtubule Organization**: Facilitates the association of microtubules with centrioles, impacting cell shape and movement.
- **Ciliogenesis**: Although primarily associated with centriole structure, its role in the organization of centrioles is foundational for cilia formation, influencing cellular signaling pathways.

### Summary
In summary, CEP135 is a crucial component of centriole biogenesis and centrosome function, with implications in neurodevelopmental disorders and potential links to age-related diseases and cellular aging processes. Further research might elucidate its direct interactions with drugs and its role in disease mechanisms.