### CCDC102B Gene Overview

**Gene Symbol:** CCDC102B  
**Location:** Human chromosome 8

**Function:** The CCDC102B (Coiled-Coil Domain Containing 102B) gene encodes a protein that plays a crucial role in the structure and function of centrioles—the cylindrical organelles found in cells that are important for cell division and maintaining cellular architecture. During interphase, CCDC102B forms fibers located at the proximal ends of the centrioles, which are vital for maintaining centrosome cohesion. Upon the onset of mitosis, the protein is phosphorylated, leading to its dissociation from the centrosome. This dissociation is an essential step that allows for centrosome separation, a critical process during cell division. Additionally, CCDC102B contributes to the formation of CROCC (centrosomal rootlet structures) and rootletin filament structures, both important for centrosome function and stability.

### Additional Information

1. **Associated Genes:**
   - **CCDC102A:** A gene with similar coiled-coil domain characteristics.
   - **CROCC (Centrosome/CP Association Protein):** Engages with CCDC102B in centrosomal functions.
   - **Rootletin:** A structural component of rootlet fibers associated with centrioles.

2. **Aging and Age-Related Diseases:**
   - While specific studies directly linking CCDC102B with aging or age-related diseases are limited, its role in centrosome function suggests that disturbances in CCDC102B function could contribute to age-related cellular dysfunction, particularly in tissue regeneration and maintenance.
   - Abnormalities in centrosome dynamics have been associated with various age-related degenerative diseases and cancer, suggesting that CCDC102B may have secondary implications in these contexts.

3. **Drug Interactions:**
   - Currently, there are no specific drugs or drug classes known to directly interact with CCDC102B based on available literature. However, drugs that affect cell cycle regulation, such as antimitotics (e.g., paclitaxel) or kinase inhibitors that may alter phosphorylation states, could indirectly affect the function of CCDC102B during mitosis.

4. **Pathways and Biological Processes:**
   - **Centrosome Cycle:** CCDC102B is essential in regulating the assembly and disassembly of centrioles during mitosis and interphase.
   - **Cytoskeleton Organization:** It contributes to the spatial organization of the cytoskeleton, important for cellular stability and movement.
   - **Regulation of Cell Division:** As part of the complex processes related to cell cycle progression, it plays a key role in ensuring proper segregation of chromosomes during mitosis.
   - **Response to DNA Damage:** There is evidence that centrosome stability is critical for maintaining genomic integrity, suggesting a potential role for CCDC102B in DNA damage response pathways.

### Summary
CCDC102B is a centriolar protein critical for centrosome cohesion and segregation during cell division. Its associative roles with other centriolar proteins, potential implications in age-related cellular processes, and its involvement in essential biological pathways highlights its significance in both basic cellular function and the broader context of cellular aging and disease. Further studies might illuminate more specific associations and therapeutic implications.