### NOP58 Gene Detailed Overview

**Gene Symbol**: NOP58  
**NCBI Gene ID**: 4853  
**UniProt Accession**: Q9UHA3

#### 1. Gene Associations
The NOP58 gene interacts with several other genes and proteins significant for ribosome biogenesis and nucleolar function. While the summaries mentioned U3, U8, and U14 snoRNAs, other associated components include:
- **NOP56**: Shares similar structural and functional roles in the box C/D snoRNPs.
- **FBL**: (Fibrillarin) - Another nucleolar protein that works closely with NOP58 in ribosome biogenesis.
- **RPS6**: Ribosomal protein that can also be a part of signaling pathways involving the functions of snoRNPs.
- **RPL5 & RPL11**: Ribosomal proteins involved in the assembly of ribosomal subunits.

#### 2. Aging and Age-Related Diseases
Research has shown that genes implicated in ribosome biogenesis, including NOP58, can have a significant role in cellular aging and age-related diseases:
- **Cellular Senescence**: Impaired ribosome biogenesis can contribute to cellular senescence, a hallmark of aging.
- **Cancer**: Disruption in nucleolar function, including that involving NOP58, can result in altered cell growth, a characteristic of cancerous transformation.
- **Neurodegeneration**: There is emerging evidence indicating that disturbances in ribosome biogenesis and nucleolar integrity may relate to neurodegenerative disorders.

#### 3. Drug Interactions
While specific drugs directly targeting NOP58 are not well-documented, several classes of agents affecting ribosome biogenesis or nucleolar stress may indirectly interact with pathways involving NOP58:
- **Antibiotics**: Certain ribosome-targeting antibiotics (like aminoglycosides) may have implications in gene expression related to ribosomal function.
- **Immunosuppressants**: Drugs that modulate immune responses may also affect nucleolar functions indirectly, especially those that influence cell proliferation.
- **Antineoplastic agents**: Some cancer therapies aiming to modulate the cell cycle or disrupt ribosome biogenesis could influence genes involved in these processes, including NOP58.

#### 4. Pathways and Biological Processes
NOP58 is fundamentally involved in several key biological pathways:
- **Ribosome Biogenesis**: Primarily, NOP58 is critical for 60S ribosomal subunit maturation, functioning in the assembly of ribosomal components in the nucleolus.
- **Small Nucleolar RNA (snoRNA) Biogenesis**: It plays a significant role in the production and maturation of box C/D snoRNAs, which are necessary for the chemical modifications of rRNA.
- **RNA Processing**: NOP58 is a part of the SSU processome, involved in the early processing of pre-rRNA.
- **RNA Exosome Complex**: NOP58 is implicated in the targeted degradation of pre-ribosomal RNA, an essential step in maintaining RNA quality and regulation.

### Conclusion
The NOP58 gene is pivotal for core nucleolar functions, particularly ribosome assembly and snoRNA biogenesis. Aberrations in its function may play critical roles in the aging process and the development of age-associated diseases and cancer, highlighting its importance as a subject of study in the fields of genomics, aging, and therapeutic interventions.