### EPHB6 Gene Overview

**Gene Symbol:** EPHB6  
**Location:** Chromosome 7q11.2  
**Protein Accession:** Q1JNZ2  

The EPHB6 gene encodes a receptor belonging to the Eph receptor family, specifically targeting ephrin-B family ligands. Uniquely among Eph receptors, EPHB6 is characterized by the absence of a functional kinase domain, influencing a variety of cellular processes primarily related to cell adhesion and migration.

### Additional Associated Genes

While the NCBI and UniProt summaries do not mention specific genes associated with EPHB6, several interacting partners and relevant signaling pathways may be inferred:

1. **EPHB2** and **EPHB3** – Other Eph receptors that may interact with ephrin ligands.
2. **JNK Pathway Genes** – Since EPHB6 inhibits JNK activation, components involved in the JNK signaling cascade may show association.
3. **TCR Signaling Genes** – Given its role in T-cell receptor signaling, genes such as CD3, CD28, and CTLA4 may also be related.

### Aging and Age-Related Diseases

Currently, research specifically linking EPHB6 to aging or age-related diseases is limited; however, the downregulation of EPHB6 expression during tumor progression indicates a potential role in cancer-related aging phenomena. EPHB6’s function in modulating cell migration and adhesion suggests it may also impact age-related processes such as cellular senescence, wound healing, and tissue regeneration. Further studies are needed to clarify these connections.

### Drug Interactions

As of the latest data, there are no specific drugs mentioned in databases like DrugBank that directly target EPHB6. However, given its role in cell signaling and tumor biology, compounds that modulate Eph receptor pathways or influence cell migration and adhesion may indirectly intersect with EPHB6's functions. This includes:

1. **Ephrin-mimetic compounds** – These could potentially influence EPHB6's activity.
2. **Immunomodulators** – Certain agents targeting T-cell activity may indirectly be influenced by EPHB6 signaling.

### Pathways and Biological Processes

EPHB6 is involved in several key biological pathways:

1. **Ephrin receptor signaling** – Modulating signaling interactions between Eph receptors and ephrin ligands.
2. **Cell adhesion and migration** – Contributing to the dynamics of cellular movements, particularly in immune responses and tumor cell behaviors.
3. **Wound healing** – Facilitating proper cell migration and organization during tissue repair processes.
4. **Regulation of cytosolic calcium levels** – Possible involvement in interactions contributing to intra-cellular signaling.

### Summary

EPHB6 is a unique kinase-defective receptor implicated in various cellular processes, particularly cell adhesion and migration, with potential roles in cancer biology and immunology. Further research is needed to understand its connections to aging and therapeutic pathways.