### CCR3 Gene Summary

**Gene Symbol:** CCR3  
**Location:** Chromosomal region 3p21  
**Gene Type:** Protein-coding

**Function:**  
The CCR3 gene encodes a receptor that is primarily associated with C-C type chemokines. As a G protein-coupled receptor, it plays a pivotal role in immune response by facilitating the migration and activation of eosinophils, basophils, and other inflammatory cells, particularly in the context of allergic reactions. CCR3 also acts as an entry co-receptor for the human immunodeficiency virus type 1 (HIV-1).

### 1. Associated Genes
While the summaries provided focus on CCR3, the following genes are often studied in relation to CCR3 due to their roles in chemokine signaling and inflammatory processes:

- **CCL11 (Eotaxin)**: A primary ligand for CCR3, involved in eosinophil recruitment.
- **CCL26 (Eotaxin-3)**: Another ligand interacting with CCR3.
- **CCL7 (MCP-3)** and **CCL13 (MCP-4)**: Chemokines that bind to CCR3, involved in various inflammatory responses.
- **CCR1, CCR2, CCR4, CCR5**: Other chemokine receptors that may share pathways and biological functions with CCR3.
- **NARS1**: Mentioned as a potential functional receptor, indicating related signaling mechanisms.

### 2. Aging and Age-Related Diseases
Research has suggested potential roles for chemokine signaling, including CCR3, in age-related diseases:

- **Asthma and Allergies**: The dysregulation of CCR3 in elderly populations can lead to heightened susceptibility to asthma and allergic responses.
- **Atherosclerosis**: CCR3-mediated eosinophil accumulation and activation may contribute to inflammatory responses associated with vascular aging and cardiovascular diseases.
- **Chronic Inflammation**: Increased expression of CCR3 in aging may be linked to chronic inflammatory states, influencing the progression of age-related conditions.

### 3. Drug Interactions
Several drugs and drug classes have been studied for their interaction with CCR3:

- **Antihistamines**: These can modulate allergic responses influenced by CCR3 signaling.
- **CCR3 Antagonists**: Specific small molecules that inhibit CCR3 are under investigation for therapeutic roles in asthma and allergic conditions.
- **HIV-1 Entry Inhibitors**: Certain drugs that target co-receptors for HIV, including CCR3, hold potential in HIV treatment.

### 4. Pathways and Biological Processes
The CCR3 gene is involved in various biological pathways and processes:

- **Chemokine Signaling Pathway**: Direct involvement in pathways that govern immune cell migration and activation.
- **Inflammatory Response**: CCR3 plays a significant role in orchestrating the inflammatory response, particularly in allergies and other hypersensitivity reactions.
- **Cell Adhesion and Migration**: Involved in processes that allow eosinophils and basophils to traffic toward sites of inflammation.
- **HIV Infection Pathways**: As a co-receptor, CCR3 is implicated in the pathways by which HIV gains entry into target cells.

### Conclusion
The CCR3 gene plays a crucial role in immunological processes and has significant implications in allergy-related responses, HIV susceptibility, and potential age-related pathologies. Ongoing research continues to unveil the complexities of its interactions and the therapeutic potentials surrounding its modulation.