### SNORD114-23 Gene Overview

**Gene Symbol:** SNORD114-23  
**Type:** Small nucleolar RNA (snoRNA) gene

SNORD114-23 is part of the C/D box small nucleolar RNA (snoRNA) family, which are primarily involved in the modification of ribosomal RNA (rRNA) through methylation. It functions in the nucleolus and is thought to serve as a molecular guide, directing the location of specific modifications on rRNA.

### 1. Associated Genes

While specific associations with other genes are often context-dependent and largely intertwined with regulatory pathways or functional complexes, some genes that are generally discussed in relation to snoRNAs include:

- **RNU4-1 (also known as U4 snRNA)**: a small nuclear RNA involved in splicing.
- **SNRPN**: implicated in genomic imprinting and primarily affects the Prader-Willi and Angelman syndromes.
- **DOK7**: involved in neuromuscular transmission.

It’s worth mentioning that snoRNAs like SNORD114-23 can exert influence on various genes indirectly by modifying rRNA and, through that, affecting protein synthesis.

### 2. Aging and Age-Related Disease Associations

As of my last update, there is limited direct literature linking SNORD114-23 specifically to aging or age-related diseases. However, snoRNAs have been implicated in various cellular processes that could be linked to aging, including:

- **Cellular senescence:** Changes in snoRNA expression profiles have been noted in senescent cells.
- **Alzheimer's Disease (AD):** Some small nucleolar RNAs have been associated with neurodegeneration, although a specific role for SNORD114-23 in AD hasn't been definitively established.
- **Cancer:** Altered expression of snoRNAs, including some from the SNORD114 family, has been implicated in tumorigenesis and cancer progression.

### 3. Drug or Drug Classes Interaction

As of October 2023, there is no specific drug or drug class that has been explicitly linked to SNORD114-23. However, given its involvement in ribosome production and function, hypothetically drugs targeting ribosome biogenesis or RNA metabolism could have indirect effects. Certain cancer therapies that target genetic networks involved in oncogenesis might also influence snoRNA expression, though that would be indirect.

### 4. Pathways and Biological Processes

SNORD114-23 is typically involved in the following pathways and biological processes:

- **rRNA modification:** It contributes to the post-transcriptional modification of rRNA, which is critical for ribosome function.
- **RNA methylation:** It is involved in methylating specific rRNA positions, thus influencing ribosome assembly and function.
- **Pre-rRNA processing:** As part of the snoRNA family, it plays a role in the maturation of pre-rRNA molecules into functionally mature ribosomal RNA.

Overall, although SNORD114-23 is less studied compared to other well-characterized genes, its role as a snoRNA suggests it participates in fundamental cellular processes, particularly around ribosome function and potentially in various aspects of gene regulation and cellular aging. Further research is required to fully elucidate its specific functions and implications in health and disease.