### TGFB3 Gene Overview:

**Gene Symbol**: TGFB3  
**Chromosomal Location**: 14q24.3  
**Gene Type**: Protein-coding  

### 1. Associated Genes:
The TGFB3 gene is part of a larger regulatory network involving other genes in the TGF-beta superfamily and related signaling pathways. Some genes that have functional or regulatory associations include:
- **TGFB1 and TGFB2**: These are other members of the TGF-beta family that share somewhat similar biological roles.
- **SMAD Family Genes (e.g., SMAD2, SMAD3, SMAD4)**: These proteins function as transcription factors and are involved in mediating the signaling pathways activated by TGF-beta ligands.
- **ACVRL1 (Activin A receptor type II-like 1)**: Involved in signaling as part of the TGF-beta superfamily pathways.
- **SNAI1 and SNAI2**: These genes are involved in epithelial-mesenchymal transition (EMT), which is influenced by TGF-beta signaling.

### 2. Aging and Age-related Diseases:
Research indicates that TGF-beta signaling, including that mediated by TGFB3, often changes with age. Dysregulation of TGF-beta signaling is associated with various age-related conditions such as:
- **Tissue fibrosis**: Increased TGF-beta activity may lead to abnormal accumulation of extracellular matrix components and fibrosis.
- **Cardiovascular diseases**: Elevated TGF-beta signaling is implicated in the development of hypertension and age-related vascular changes, including aortic aneurysms.
- **Wound healing and tissue regeneration**: Age-associated declines in TGF-beta signaling can impair wound healing, leading to chronic wounds in older adults.

### 3. Drug Interactions:
Several drug classes and specific drugs may interact with the TGF-beta signaling pathway, including:
- **TGF-beta inhibitors**: These include small molecule inhibitors like **Galunisertib** (LY2157299) that specifically inhibit TGF-beta receptor signaling and are under investigation for cancer treatment.
- **Immunosuppressive agents**: Drugs such as **cyclosporine** and **rapamycin** have been shown to impact TGF-beta signaling, potentially affecting fibrosis and inflammation.
- **Anti-fibrotic agents**: Such as **pirfenidone** and **nintedanib**, which target TGF-beta related pathways, are used in fibrotic diseases like idiopathic pulmonary fibrosis.

### 4. Pathways and Biological Processes:
The TGFB3 gene is involved in a multitude of biological processes and signaling pathways, including, but not limited to:
- **TGF-beta signaling pathway**: Central to many developmental processes, including cell growth, differentiation, apoptosis, and tissue homeostasis.
- **Embryogenesis**: Essential for the development of various tissues and organs.
- **Cell differentiation**: Influential in mesenchymal stem cell differentiation into chondrocytes, osteoblasts, and myocytes.
- **Wound healing**: Contributing to processes such as collagen deposition, inflammation, and tissue remodeling.

##### Summary:
The TGFB3 gene encodes a significant member of the TGF-beta superfamily, playing crucial roles in embryogenesis, cell differentiation, and mediating various physiological and pathological processes, particularly in relation to the cardiovascular system and potential age-related problems. Understanding the interactions and pathways associated with TGFB3 can enhance insights into its function and relevance in health and disease.