### AHCTF1 Gene Overview

**Gene Symbol:** AHCTF1  
**Chromosomal Location:** This gene is located on chromosome 5, but exact coordinates may vary depending on the genome assembly used.

#### Function and Role
The AHCTF1 gene encodes a protein that is essential for the assembly of the nuclear pore complex (NPC) during the late stages of mitosis, ultimately playing a crucial role in maintaining cellular integrity and function. The protein is believed to bind to chromatin, facilitating the recruitment of the Nup107-160 subcomplex, a critical component of the NPC. AHCTF1 also has implications in cellular processes such as:

1. **Nuclear Pore Complex Assembly:** It aids in the systematic arrangement and functionality of the NPC, which is necessary for nucleocytoplasmic transport.
   
2. **Cytokinesis Regulation:** AHCTF1 is required for the proper division of the cytoplasm during cell division, ensuring that daughter cells receive equal regulatory and genetic materials.

3. **Kinetochore Localization:** The gene also supports the correct localization of the Nup107-160 subcomplex to the kinetochore, which is crucial for proper chromosome segregation.

#### Associated Genes
While specific genes directly associated with AHCTF1 are not always detailed in summaries, it is often linked with other components of the nuclear pore complex such as:

- **NUP107** 
- **NUP160**
- **NUP133**

Additionally, it interacts with kinetochore proteins and may have indirect relations to genes involved in cytokinesis.

#### Aging and Age-Related Diseases
Research into AHCTF1 specifically in the context of aging is limited. However, as the NPC is implicated in various cellular processes including aging and cellular senescence, any dysfunction in AHCTF1 could potentially contribute to age-related diseases. Mutations or dysregulation in genes involved in nuclear pore assembly, including AHCTF1, may be linked to cellular miscommunication, increased senescence, and diseases such as cancer, neurodegenerative disorders, and other aging-related conditions.

#### Drug Interactions
Currently, there are no specific drugs or drug classes directly targeting AHCTF1 mentioned extensively in the literature. However, due to its role in cell division and the NPC, investigations into agents that affect mitosis or cellular transport could cross paths with pathways influencing AHCTF1 activity.

#### Pathways and Biological Processes
AHCTF1 is involved in several key biological pathways, including:

1. **Nuclear Pore Complex Assembly:** Directly associated with the formation of the NPC during telophase of the cell cycle.

2. **Cell Cycle Regulation:** Implicated in the processes ensuring proper cell division and regulation of mitotic phases.

3. **Cytokinesis:** Essential for the physical separation of daughter cells post-mitosis.

4. **Chromatin Organization:** An indirect role in organizing and managing chromatin structures during cell division.

5. **Nuclear Transport:** Due to its function within the NPC assembly, it plays a role in the selective transport between the nucleus and cytoplasm.

Overall, AHCTF1 is a critical player in cellular processes that are essential for maintaining genetic stability and proper cell function, with implications that may extend into aging research and cellular pathology. Further studies are needed to clarify its exact roles in these areas.