### DDX54 Gene Overview

**Gene Symbol:** DDX54  
**Location:** Chromosome 10 

**Function:** The DDX54 gene encodes a member of the DEAD box protein family, which are RNA helicases that facilitate various RNA-related processes. Its primary functions include the unwinding of RNA structures and modulation of RNA-protein interactions in vital cellular processes like translation, ribonucleoprotein complex assembly, and splicing. Additionally, DDX54 is known to partake in transcriptional repression of nuclear receptors in a hormone-dependent manner, implicating it in regulatory pathways of gene expression.

### 1. Associated Genes
While the gene summaries you've provided focus mainly on DDX54, members of the DEAD box protein family and other genes involved in RNA metabolism and splicing may be associated, such as:
- **DDX5**: Known to have roles in RNA regulation, similar to DDX54.
- **DDX26**: Another DEAD box protein involved in RNA splicing.
- **HNRNPA1**: Functions in mRNA processing and transport, which may interact with DDX54.

### 2. Aging and Age-Related Diseases
Research on DDX54's specific connection to aging or age-related diseases remains limited. However, it's crucial to explore links between RNA metabolism and age-related cellular processes. Dysregulation of RNA helicases like DDX54 can contribute to:
- **Cellular senescence**: Altered RNA processing may impact cellular growth and functionality as one ages.
- **Cancer**: Given its role in RNA processing and transcriptional regulation, misregulation of DDX54 has the potential to influence tumorigenesis and the progression of age-related malignancies.

### 3. Drug Interactions
While specific drug interactions targeting DDX54 have not been extensively cataloged, its role in RNA metabolism might connect it to:
- **Antiviral agents**: Drugs that target RNA viruses may inadvertently affect RNA helicases like DDX54. 
- **Hormone modulators**: Since DDX54 interacts with nuclear receptors in a hormone-dependent manner, drugs that modulate hormone levels or receptor activity could influence its activity.

### 4. Pathways and Biological Processes
DDX54 is involved in several biological pathways and processes that include:
- **RNA metabolism**: Plays a role in various aspects of RNA processing including splicing, translation initiation, and ribonucleoprotein assembly.
- **Hormonal signaling cascades**: Modulates the transcriptional activity of hormone-responsive genes through its interaction with nuclear receptors.
- **Cell proliferation and differentiation**: Given its involvement with RNA processes, DDX54 likely influences cellular growth and differentiation mechanisms.

### Summary
The DDX54 gene is a multifunctional RNA helicase with significant roles in gene expression regulation and RNA metabolism. Its potential connections to various biological processes, aging, and disease mechanisms warrant further exploration for therapeutic implications in age-associated conditions and cancer.