### S1PR3 Gene Overview

**Gene Symbol:** S1PR3  
**Gene Description:** The S1PR3 gene encodes a protein that is a member of the endothelial differentiation gene (EDG) family of G protein-coupled receptors. This receptor is a high-affinity binding site for sphingosine 1-phosphate (S1P), a lysophospholipid that plays a critical role in numerous cellular processes, including proliferation, migration, and survival. S1PR3 is implicated in the regulation of angiogenesis, vascular permeability, and endothelial cell function.

### 1. Associated Genes

S1PR3 is known to interact or have associations with various genes involved in signaling pathways and cellular functions, including but not limited to:
- **S1PR1** - This gene encodes another receptor for sphingosine 1-phosphate and shares functional properties with S1PR3.
- **S1PR2** - Another member of the sphingosine 1-phosphate receptor family that may have overlapping functions.
- **EDG1** - This gene, synonymous with S1PR1, is related to the sphingosine receptor signaling pathway.
- **AKT1** - Involved in signal transduction pathways that influence cell survival and growth.
- **VEGFA** - This gene is pivotal in angiogenesis and may work along with S1PR3 signaling.

### 2. Aging and Age-Related Diseases

Research has indicated that sphingosine 1-phosphate receptors, including S1PR3, may play roles in age-related conditions, particularly cardiovascular diseases, due to their involvement in vascular function and endothelial health. Aging has been linked to increased inflammation and vascular dysfunction, where S1PR3 signaling may alter the endothelial response to vascular injury and ischemia. Additionally, S1PR3 has been implicated in:
- **Cardiovascular diseases:** Inflammation and atherogenesis.
- **Alzheimer’s disease:** S1P signaling is involved in neuroprotective mechanisms, and altered S1PR3 function may contribute to neurodegeneration.
- **Cancers:** Dysregulated S1P signaling, including S1PR3, can influence tumor growth and metastasis.

### 3. Drug Interactions

Several drugs and drug classes have been associated with S1PR3 or target S1P signaling pathways. Known substances include:
- **Sphingosine-1-phosphate modulators:** Such as fingolimod (FTY720), used in the treatment of multiple sclerosis; it modulates S1PRs including S1PR3.
- **Anticancer agents:** Some chemotherapeutics affect S1P signaling, casting S1PR3 as a target for cancer treatment strategies.

### 4. Pathways and Biological Processes

S1PR3 is involved in several key pathways and biological processes, including:
- **G protein-coupled receptor signaling pathway:** It mediates cellular responses to sphingosine 1-phosphate via G proteins.
- **Angiogenesis:** Plays a significant role in new blood vessel formation through endothelial cell migration and proliferation.
- **Vascular permeability:** S1PR3 regulates the permeability of blood vessels, affecting fluid and cell movement in tissues.
- **Apoptosis regulation:** The receptor is associated with signaling mechanisms that can suppress apoptosis in various cell types.
- **Inflammation:** S1PR3 signaling is involved in the inflammatory response, particularly within the vascular system.

In summary, S1PR3 is a multifunctional receptor with implications in cardiovascular health, cancer biology, and potential roles in aging-related mechanisms. Its associations with other genes, pathways, and pharmacological agents highlight its importance in various physiological and pathological contexts.