### SNORD116-1 Gene Overview

**Gene Symbol:** SNORD116-1  
**Location:** Chromosome 15 (15q11.2)  
**Function:** SNORD116-1 is a small nucleolar RNA (snoRNA) gene that is primarily involved in the processing and modification of other RNA molecules. It is part of a larger gene family involved in the modification of ribosomal RNA, and it contributes to the biogenesis of the ribosome.

### Additional Gene Associations

1. **Associated Genes:**
   - SNORD116-2: Another snoRNA located closely on chromosome 15 that shares similar features with SNORD116-1.
   - **UBE3A (Ubiquitin Protein Ligase E3A):** Loss of function mutations in this gene have been implicated in Angelman syndrome, a condition linked to the 15q11-q13 region, where SNORD116-1 is located.
   - **GABRB3 (Gamma-Aminobutyric Acid Type B Receptor Subunit Beta-3):** A gene also located in the imprinted region of chromosome 15, associated with neurological functions.
   - **ATP10A (ATPase cation transporting 10A):** Another gene in the same genomic region, involved in neurotransmitter signaling.

### Aging and Age-Related Diseases

1. **Age-Related Implications:**
   - Studies have shown that alterations in snoRNA expression, including SNORD116-1, can be associated with age-related conditions and diseases. 
   - Imbalances in the expression of snoRNAs have been linked to cancer and neurodegenerative diseases, suggesting potential roles of SNORD116-1 in modifying cellular aging processes and response to stress.

2. **Clinical Associations:**
   - Given its location within the imprinted domain, variations in SNORD116-1 expression may also influence neurological disorders, including conditions related to cognitive decline in aging populations.

### Drug Interactions

- Currently, there are no specific drugs or drug classes that have been directly associated with SNORD116-1. However, its role in RNA processing may implicate it in potential pathways affected by various therapeutics targeting gene expression modulation (e.g., antisense oligonucleotides or small interfering RNAs) and cancer therapies that impact RNA synthesis.

### Pathways and Biological Processes

- **Biological Processes:**
  - **RNA Modification:** SNORD116-1 is involved in the methylation of ribosomal RNA, a critical process for ribosome function and protein synthesis.
  - **Regulation of Gene Expression:** As a snoRNA, it may contribute to the regulation of various gene expression networks through its interactions with RNA-binding proteins.

- **Pathways:**
  - SNORD116-1 may play a role in the **Nuclear RNA processing** pathways, particularly in the biogenesis of rRNA.
  - Involved in **pre-rRNA processing**, which is essential for ribosome assembly.
  
In summary, while SNORD116-1 is primarily recognized for its role as a small nucleolar RNA involved in RNA processing, its interactions with other genes and implications in age-related diseases and potential drug pathways warrant further investigation.