### SETP15 Gene Overview

**Gene Symbol**: SETP15  
**Scientific Context**: The SETP15 gene is part of a family of genes associated with various cellular processes, including epigenetic regulation, chromatin remodeling, and possibly in the pathways underlying several diseases.

### 1. Associated Genes

While the NCBI and UniProt summaries may not provide an exhaustive list of associations, SETP15 may have functional relationships with other genes in the same pathways or complexes. Based on currently available research, some genes that could be associated with or regulated by SETP15, considering pathways and related processes, may include:

- **SETD2**: Another SET domain-containing protein involved in histone modification.
- **KDM5A**: A gene encoding a histone demethylase that may interact with SETP15 during transcriptional regulation.
- **PRC2 complex components**: Such as EZH2, which is involved in gene silencing and may intersect with the functions of SETP15.

### 2. Aging and Age-Related Diseases

While there may be limited specific data focusing on SETP15 and its direct role in aging or age-related diseases, genes in the SET family are often implicated in epigenetic regulation. Alterations in epigenetic markers are a hallmark of aging and have been associated with age-related diseases such as:

- **Cancer**: Mutations or dysregulation of genes like SETP15 may contribute to tumorigenesis.
- **Neurodegenerative Diseases**: Genes regulating chromatin structure and gene expression typically affect neuronal health and could be involved in conditions like Alzheimer's disease.

### 3. Drug Interactions

The interactions between drugs or drug classes with SETP15 may not be well-characterized due to its relatively specific role in gene regulation and the limited information regarding direct pharmacological responses. However, drugs that target epigenetic modifiers, such as:

- **Histone deacetylase inhibitors (HDACi)**: These compounds might influence the activity of SETP15 indirectly by affecting the chromatin state and gene expression.
- **DNA methyltransferase inhibitors**: Such as azacitidine, which can modulate the epigenetic landscape.

Further research is necessary to fully characterize direct drug-gene interactions.

### 4. Pathways and Biological Processes

SETP15 is involved in various biological processes and pathways, which may include, but are not limited to:

- **Chromatin organization**: SET domains typically modify histones and affect chromatin structure.
- **Gene expression regulation**: Involvement in enhancer-promoter interactions and transcriptional silencing.
- **Cell cycle regulation**: As part of the epigenetic control mechanisms that govern cellular proliferation.

**Key Pathways**: The precise signaling pathways SETP15 is involved in are still being elucidated, but it potentially plays a role in the regulation of pathways associated with:

- **Developmental processes**
- **Alterations in cell signaling**
- **Responses to DNA damage**

### Summary

While there is still much research to be conducted on SETP15, it is recognized for its role in the modulation of epigenetic landscapes. The pathways and associations with diseases highlight its potential importance in cellular aging and related pathologies, although direct links to drugs and clinical applications require further investigation.