### FAM107A Gene Overview

The **FAM107A** gene (Family with sequence similarity 107 member A) encodes a protein with a significant role in actin dynamics and various cellular processes, particularly in the context of the cytoskeleton, cell cycle regulation, and synaptic function. Below is a detailed exploration based on your request.

#### 1. Associated Genes

FAM107A has been associated with several other genes, particularly those involved in cytoskeletal dynamics, cell cycle regulation, and neurobiology. Notably:

- **MAP1A (Microtubule-Associated Protein 1A)**: Involved in microtubule regulation and has a role in neuronal development.
- **RELA (NF-kappa-B subunit)**: This gene is crucial for the NF-kappa-B signaling pathway, which FAM107A impacts by promoting its degradation.
- **COMMD1 (Copper Metabolism MURR1 Domain 1)**: Known to participate in the regulation of NF-kappa-B and is implicated in various developmental and pathological processes.
- **ACTB (Actin Beta)** and **GAPDH (Glyceraldehyde-3-phosphate dehydrogenase)**: General housekeeping genes that are also involved in cellular actin dynamics.

#### 2. Age-Related Associations

While there may not be specific age-related diseases explicitly linked to FAM107A, its involvement in processes associated with synaptic function, learning, and memory suggests potential implications in age-related cognitive decline and neurodegenerative diseases such as Alzheimer's. Abnormalities in cytoskeletal dynamics and actin regulation can lead to synaptic dysfunction, which is a hallmark of neurodegenerative conditions.

- **Neurodegeneration and Cognitive Decline**: As FAM107A is involved in synaptic plasticity and cognitive functions, its dysregulation may contribute to age-related diseases characterized by cognitive impairment.

#### 3. Drug Interactions

While there may not be a comprehensive list of drugs that directly target FAM107A, the gene’s involvement in pathways relating to cell cycle regulation and oncogenesis implies possible interactions with the following drug classes:

- **Chemotherapeutic Agents**: Drugs targeting cell cycle pathways (e.g., inhibitors of NF-kappa-B signaling or those disrupting actin dynamics) could be relevant, particularly in the context of neuroblastoma and glioma.
- **Actin-Disrupting Agents**: Drugs such as cytochalasins (which inhibit actin polymerization) and other actin-targeting therapies might indirectly affect FAM107A's function.

#### 4. Pathways and Biological Processes

FAM107A is involved in a variety of critical biological pathways and processes, including:

- **Cell Cycle Regulation**: Particularly in the transition from G1 to S phase and the inhibition of proliferation in neuroblastoma.
- **Cytoskeleton Organization**: Regulation of actin filament dynamics and microtubule organization, impacting cellular morphology and motility.
- **Focal Adhesion Dynamics**: Negative regulation of focal adhesion assembly promoting cell migration.
- **Synaptic Functions**: Modulating neural processes critical for learning, memory acquisition, and neurite outgrowth.

#### Conclusion

FAM107A is a multifunctional gene with substantial implications for actin dynamics, synaptic functionality, and cell cycle regulation. Its interactions with other genes, potential links to age-related disorders, possible drug interactions, and participation in vital biological pathways make it a gene of interest in both basic and applied biomedical research. Further studies may elucidate its role in various diseases, particularly in the context of cancer and neurodegeneration.