### SNORA80A Gene Overview

**Gene Symbol:** SNORA80A

**Summary:** SNORA80A (Small Nucleolar RNA, C/D Box 80A) is a gene that encodes a small nucleolar RNA which is involved in the modification of other RNA molecules, particularly ribosomal RNA (rRNA). Small nucleolar RNAs are integral components of the ribonucleoprotein complexes that carry out rRNA methylation and pseudouridylation. SNORA80A is a member of the C/D box class of snoRNAs, characterized by the presence of specific sequence elements involved in guiding the modification of target RNAs.

### 1. Associated Genes
While specific associations can vary based on genetic context and conditions studied, the SNORA80A gene may be functionally and/or physically associated with other snoRNAs in the C/D box family. Additionally, certain genes that encode proteins involved in RNA processing and modification, such as those in the ribosome biogenesis pathways, could have indirect associations due to their interactions with snoRNAs. Specific examples might include:
- **NOP58** and **NOP60**, which are components of the box C/D snoRNP complexes.
- Genes involved with ribosome assembly and biogenesis, as these processes are directly influenced by snoRNA activities.

### 2. Aging and Age-related Diseases
As of now, specific research directly linking SNORA80A to aging or age-related diseases remains limited. However, snoRNAs in general have been implicated in various mechanisms of cellular aging and maintenance of RNA quality, which may indirectly associate SNORA80A with age-related processes. Altered expression of snoRNAs has been observed in certain age-related conditions, suggesting a potential role in processes like:
- Cellular senescence
- Age-related decline in ribosome biogenesis

Further studies would be required to elucidate any direct functions or correlations involving SNORA80A in the context of aging or related pathologies.

### 3. Drug Interactions
Currently, there are no well-documented drugs or drug classes that specifically target or interact with the SNORA80A gene. However, since snoRNAs ultimately influence ribosomal function and RNA processing, there might be implications in the context of drugs affecting protein synthesis or those that target ribosomes, such as:
- Antibiotics (e.g., aminoglycosides, tetracyclines) that inhibit bacterial ribosomal activity, which theoretically could be influenced by homologous pathways given the role of snoRNAs in rRNA modification.

Detailed drug interactions pertaining solely to SNORA80A's action would require specific experimental evidence, which may not yet be published or available.

### 4. Pathways and Biological Processes
SNORA80A is involved in several biological pathways primarily related to:
- **Ribosome biogenesis**: It contributes to the modifications of rRNA, which are essential for the correct assembly and function of ribosomes.
- **rRNA methylation and pseudouridylation**: As a snoRNA, SNORA80A serves as a guide for specific modifications in rRNA, altering the structural properties and stability of the ribosome.
- **RNA processing**: It is likely to interact with other RNA processing complexes involved in the maturation and post-transcriptional modification of RNA molecules.

Overall, while SNORA80A may not yet have conclusively recognized associations with specific diseases, its role in modulating ribosomal function and potential connections to broader cellular processes position it as a gene of interest in the study of molecular biology and the mechanics of aging. Further research may clarify its functional implications, especially regarding health and disease.