### CCDC88C Gene Overview

**Gene Symbol**: CCDC88C  
**Location**: Chromosome 10  
**Function**: The CCDC88C gene encodes a coiled-coil domain-containing protein that is an essential player in regulating the Wnt signaling pathway, particularly in its non-canonical forms. This gene is known to negatively regulate canonical Wnt signaling by interacting with dishevelled proteins (DVL) and G-proteins.

### 1. Associated Genes
CCDC88C has been associated with several genes and proteins beyond those mentioned in summaries:

- **DVL1 (Dishevelled Segment Polarity Protein 1)**: Core component of the Wnt signaling pathway.
- **FZD7 (Frizzled Class Receptor 7)**: A receptor for Wnt protein involved in both canonical and non-canonical signaling.
- **GNAI1 (Guanine Nucleotide Binding Protein, Alpha Inhibitory 1)**: Primary G-protein with which CCDC88C interacts.
- **RAC1 (Ras-related C3 botulinum toxin substrate 1)**: Involved in cytoskeletal dynamics and cellular movement.
- **ARHGEF18 (Rho Guanine Nucleotide Exchange Factor 18)**: May mediate apical constriction involved during cellular morphogenesis.

### 2. Aging and Age-Related Diseases
While direct associations of CCDC88C with aging or age-related diseases are limited, its role in the Wnt signaling pathway links it to several processes related to aging such as tissue homeostasis, regeneration, and cancer progression. Abnormal Wnt signaling has been implicated in various age-associated conditions including:

- **Neurodegenerative Diseases**: Alterations in Wnt signaling may affect neurogenesis, synaptic plasticity, and neuronal survival.
- **Cancer**: Dysregulation of Wnt signaling is a common feature in many cancers, and CCDC88C's negative regulatory role in this pathway emphasizes its potential relevance in cancer treatment and progression in older adults.

### 3. Drug Interactions
There are no specific drug interactions noted directly with CCDC88C. However, compounds that modulate Wnt signaling, such as:

- **Wnt Pathway Inhibitors**: These may indirectly target the biological processes regulated by CCDC88C.
- **G-protein Inhibitors**: Because CCDC88C acts as a guanine nucleotide exchange factor, drugs that influence G-protein signaling pathways might intersect with its activity.

#### Potential Drug Classes:
- **Antineoplastics**: Drugs impacting Wnt signalling have potential clinical uses in cancer treatment which may indirectly affect the pathways involving CCDC88C.
- **Signal Transduction Modulators**: Agents that alter G-protein signaling pathways could interact with pathways influenced by CCDC88C.

### 4. Pathways and Biological Processes
**Key Pathways**: 
- **Wnt Signaling Pathway**: Particularly the non-canonical Wnt signaling pathway.
- **Signal Transduction**: Involves G-protein coupled receptor signaling.
- **Cell Morphogenesis**: Promotes cellular arrangements and structures during embryogenesis.

**Relevant Biological Processes**:
- **Development**: Essential roles in embryonic development and tissue specification.
- **Cell Migration**: Influences cellular movement and polarization.
- **Neurogenesis**: Potentially relates to the formation of new neurons in the developing brain.
- **Hydrocephalus Pathogenesis**: Mutation-related processes leading to hydrocephalus point to roles in brain development and cerebrospinal fluid dynamics.

### Conclusion
Overall, CCDC88C serves a multifaceted role in essential signaling pathways with significant implications in developmental biology, neurogenesis, and possibly in the pathology of age-related diseases and cancer. Further research may elucidate more specific roles and therapeutic targets connected to this gene in different biological contexts.