### GART Gene Overview

**Gene Symbol**: GART  
**Chromosomal Location**: Human Chromosome 21q22.3

**Protein Function**:  
The GART gene encodes a trifunctional polypeptide involved in the de novo biosynthesis of purines. It catalyzes three enzymatic activities:
1. Phosphoribosylglycinamide formyltransferase (FGAM synthase)
2. Phosphoribosylglycinamide synthetase
3. Phosphoribosylaminoimidazole synthetase

These reactions play crucial roles in the production of inosine monophosphate (IMP), a precursor for adenosine and guanosine nucleotides.

### 1. Associated Genes
The GART gene is related to several other genes involved in nucleotide metabolism and purine biosynthesis. Notable associated genes include:
- **PAICS**: Involved in the sequential steps downstream in the purine biosynthesis pathway.
- **ATIC**: Participates in the later stages of purine synthesis.
- **IMPDB**: Involved in the purine salvage pathway.
- **PRPS1**: Phosphoribosyl pyrophosphate synthetase, an important enzyme in the nucleotide biosynthesis.

### 2. Age-Related Details
Research indicates that disturbances in nucleotide metabolism, including pathways implicated by GART, can lead to age-related diseases. Known associations include:
- **Cancer**: Alterations in purine metabolism linked to cell proliferation and tumorigenesis.
- **Neurodegenerative Diseases**: Impaired nucleotide homeostasis is suggested to contribute to neurodegeneration, although specific associations with GART are still an area of investigation.
- **Aging**: The regulation of nucleotide synthesis is critical for maintaining genomic stability. Mutations affecting GART functions may potentially alter aging processes at the cellular level.

### 3. Drug Interactions
GART is a target in the context of drug interactions mainly due to its role in purine metabolism. Drugs or drug classes known to interact with pathways involving GART include:
- **Antimetabolites (e.g., Methotrexate)**: These drugs inhibit folate metabolism, thus affecting the supply of nucleotides and potentially impacting GART enzymatic function.
- **Immunosuppressants (e.g., Azathioprine)**: These drugs can affect purine metabolism, potentially leading to downstream effects on GART function. 

### 4. Pathways and Biological Processes
GART is involved in multiple key pathways and biological processes, including:
- **De novo Purine Biosynthesis**: Integral to the synthesis of adenine and guanine nucleotides.
- **Cell Proliferation and Growth**: Nucleotide availability is critical for DNA and RNA synthesis, thus influencing cell cycle and replication.
- **Adenine and Guanine Metabolism**: This has implications in both normal cellular function and the management of certain diseases, particularly cancers.

In conclusion, the GART gene plays a pivotal role in nucleotide synthesis essential for cell function and proliferation while also being connected to potential implications in aging and disease. Its functionalities make it a valuable target for therapeutic intervention in conditions like cancer and other diseases where nucleic acid metabolism is perturbed.