### ITGB5-AS1 Gene Overview

**Gene Symbol:** ITGB5-AS1  
**Location:** Chromosome 2 (2q14.3)  
**Gene Type:** Long non-coding RNA (lncRNA)  
**Function:** The ITGB5-AS1 gene is known to function primarily as a regulatory element in various biological processes. It is an antisense RNA of the integrin beta-5 (ITGB5) gene, believed to play a role in modulating the expression and functional aspects of its counterpart.

### 1. Associated Genes
While the summaries from NCBI and UniProt primarily detail ITGB5-AS1, it is important to mention its association with:
- **ITGB5**: The gene that it is antisense to and is implicated in cell adhesion and signaling pathways.
- **Other integrin genes:** Given ITGB5-AS1's involvement with integrin signaling, it may also be associated with other integrin genes like **ITGA1**, **ITGA5**, and potentially other members of the integrin family, which are vital in cell interactions and tissue homeostasis.

### 2. Aging and Age-Related Diseases
Research into lncRNAs like ITGB5-AS1 suggests potential implications in aging and age-related diseases:
- **Cellular Senescence:** lncRNAs have been implicated in the regulation of senescence, which is pivotal in aging. While specific studies linking ITGB5-AS1 to senescence are limited, its regulatory role could impact aging processes.
- **Cancer:** lncRNAs, including ITGB5-AS1, have been studied in the context of tumorigenesis and metastasis. Dysregulation of integrins has been linked with cancer progression, suggesting a possible role in age-related cancer susceptibility.

### 3. Drug Interactions
Currently, the literature does not present specific drugs explicitly targeting or interacting with ITGB5-AS1. However, since it may influence the expression of ITGB5 and other integrin-related pathways, some broad categories of drugs might indirectly involve pathways associated with ITGB5-AS1:
- **Integrin inhibitors:** Used primarily in oncology and autoimmune diseases.
- **Anticancer drugs:** Many drugs targeting tumor angiogenesis may have a potential indirect influence since integrins are involved in these pathways.

### 4. Pathways and Biological Processes
ITGB5-AS1 is implicated in several biological pathways and processes, which may include:
- **Cell Adhesion:** Through its association with ITGB5, it plays a role in cell adhesion mechanisms.
- **Cell Signaling:** Influences integrin-mediated signaling pathways, which are critical for various cellular processes including proliferation and survival.
- **Gene Regulation:** As a long non-coding RNA, ITGB5-AS1 may participate in the regulation of gene expression via various epigenetic mechanisms.

There is ongoing research in these areas, and future studies may provide more precise data correlating ITGB5-AS1 with specific age-related pathologies, drug interactions, and detailed signaling pathways.