### PRMT7 Gene Overview

#### Gene Symbol: 
- **PRMT7**

#### Gene Function:
The PRMT7 gene encodes a member of the protein arginine N-methyltransferase family, primarily involved in the methylation of arginine residues on target proteins. Specifically, PRMT7 catalyzes the formation of monomethylarginines (MMA) and symmetrical dimethylarginines (sDMA), with a preference for MMA. This gene plays critical roles in various biological processes, including:

- Neuronal differentiation
- Male germline imprinting
- Biogenesis of small nuclear ribonucleoproteins (snRNPs)
- Regulation of the Wnt signaling pathway

#### Mutations and Clinical Associations:
Mutations in PRMT7 are implicated in syndromes characterized by intellectual disability, short stature, and additional developmental features. It may also influence cancer biology, notably promoting breast cancer cell invasion and metastasis.

### Additional Information

#### 1. Associated Genes:
Though the summaries provided mention certain genes and substrates, PRMT7 is also associated with:
- **CTCFL** (CCCTC-binding factor), which recruits PRMT7 for methylation activities in genomic imprinting.
- **SNRPD1** and **SNRPD3** for its role in the biogenesis of snRNPs.
- Other PRMT family members might interact with PRMT7 in regulatory networks.

#### 2. Aging and Age-Related Diseases:
Current research indicates that PRMT7 may affect cellular processes linked to aging, but specific mechanisms are still being uncovered. Some associations include:
- Cellular senescence: Dysregulation of PRMT7 could contribute to telomere shortening and senescence-associated phenotypes.
- Cancer: Age-related accumulation of mutations and epigenetic changes involving PRMTs suggest that PRMT7 may be involved in tumorigenesis and cancer progression, particularly in the elderly population.

#### 3. Drug and Drug Classes:
As of now, specific drugs directly targeting PRMT7 have not been widely identified; however, general classes of drugs that may impact its activity include:
- **Histone deacetylase (HDAC) inhibitors**: These drugs can indirectly influence arginine methylation by altering chromatin states.
- **Cancer therapeutic agents**: Some agents might act on pathways involving PRMT7 due to its association with tumor invasiveness.
There may also be ongoing research into inhibitors or modulators that could affect PRMTs, including PRMT7, as potential therapeutic approaches in cancer treatment.

#### 4. Pathways and Biological Processes:
PRMT7 is involved in various signaling pathways and biological processes, such as:
- **Gene expression regulation**: Through methylation of histones (e.g., H4R3me2s formation), it modulates access to transcriptional machinery.
- **Wnt signaling pathway**: Assists in the regulation of this pathway which is critical in cell fate determination and cancer.
- **RNA processing**: Involved in the assembly of snRNPs, essential for pre-mRNA splicing.
- **Imprint control**: Engages in the imprinting of genes, affecting allele expression depending on parental origin.

### Summary
PRMT7 is a critical gene with implications in developmental biology, cancer progression, and potentially age-related conditions. Its interactions with other genes, involvement in fundamental biological processes, and the potential for pharmaceutical targeting make it a gene of interest for ongoing research in genetics and epigenetics.