### CEP55 Gene Summary

**Gene Symbol**: CEP55 (Centrosomal Protein 55)

**Function**: CEP55 plays a critical role in mitotic exit and the process of cytokinesis, the physical separation of two daughter cells during cell division. It facilitates the recruitment of specific proteins, such as PDCD6IP (Programmed Cell Death 6 Interacting Protein) and TSG101 (Tumor Susceptibility Gene 101), to the midbody, which is crucial for the successful completion of cytokinesis. It is implicated in cranial skeletal system development, protein localization, and has specific roles in brain and kidney development.

### 1. Associated Genes
While the summaries mention PDCD6IP and TSG101, other genes commonly associated with CEP55, particularly in the context of cell division and cancer biology, may include:

- **CENPE**: This gene encodes a protein that interacts with CEP55 during mitosis.
- **EPPK1 (epithelin precursor-related keratin 1)**: May also interact in regulating cellular processes during cytokinesis.
- **RAB11A**: Involved in vesicular transport and may have related functions during cytokinesis.

### 2. Aging and Age-related Diseases
Research has shown that aberrations in CEP55 levels or function could contribute to various age-related diseases, especially cancer. Specifically:

- **Cancer**: Dysregulation of CEP55 has been linked to various cancers due to its important role in cell division. Elevated expression of CEP55 is often associated with poor prognosis in several malignancies (e.g., breast cancer, prostate cancer).
- **Neurodegeneration**: Given its involvement in neuronal development, abnormal CEP55 function may contribute to neurodegenerative diseases or age-related cognitive decline.
- **Kidney Disorders**: Its role in kidney development hints at possible implications in age-related renal diseases or congenital anomalies that can affect older populations.

### 3. Drug Interactions
Currently, specific drug interactions directly targeting CEP55 are not well established. However, drugs affecting pathways involved in cytoskeletal dynamics, cell division, or cancer therapeutics could impact CEP55 indirectly. This may include:

- **Antimitotic agents**: Such as taxanes (e.g., Paclitaxel) and Vinca alkaloids, which disrupt microtubule dynamics crucial for cytokinesis.
- **Inhibitors of cellular signaling pathways** that intersect with CEP55 functions may also impact its activity, although no direct drug has been specified.

### 4. Pathways and Biological Processes
CEP55 is involved in several pivotal biological processes and pathways, including:

- **Cytokinesis**: As a central player in the abscission and completion of cytokinesis.
- **Cell Cycle Regulation**: Part of mechanisms that ensure correct chromosomal partitioning and cellular division.
- **Brain Development**: Important for proper morphogenesis and organization of neural structures during embryonic development.
- **Kidney Development**: Implicated in renal formation and function during development.

In addition to these processes, CEP55 has associations with signaling pathways involved in cell proliferation and migration, implying critical roles in both normal physiology and pathology.

### Conclusion
The CEP55 gene is essential for proper cell division and development, particularly in the context of the brain and kidneys. Its involvement in various diseases, especially cancer, highlights its potential as a biomarker or therapeutic target, particularly in age-related contexts. Further research would benefit from elucidating its precise interactions and regulatory mechanisms in these biological processes.