### CEP63 Gene Overview:

**Gene Symbol:** CEP63  
**Function:** The CEP63 gene encodes a protein that plays a critical role in centrosome function and microtubule organization, essential for proper cell division. It contains six coiled-coil domains and primarily localizes to the centrosome, where it is involved in spindle assembly and centriole duplication. 

### 1. Associated Genes:
In addition to the genes mentioned in the NCBI and UniProt summaries, CEP63 has been associated with several other genes, including:

- **PLK4 (Polo-like kinase 4)**: Important for centriole duplication and regulation of centrosome function.
- **CEP152 (Centrosomal protein 152)**: Interacts in a complex with CEP63, indicative of their collaborative role in centriole biogenesis.
- **KIFC1 (Kinesin Family Member C1)**: Involved in microtubule organization during mitotic processes.
- **TPX2 (TPX2 microtubule nucleator)**: Functions in microtubule organization and spindle assembly.
- **AURKA (Aurora Kinase A)**: Plays a role in mitotic processes, including centrosome maturation and spindle assembly.

### 2. Aging and Age-Related Diseases:
Research indicates that defects in the functions of centrosomal proteins like CEP63 are linked to aging and age-related diseases:

- **Aging:** The integrity of centrosomes is vital for maintaining genomic stability, which may decline with age due to the accumulation of mutations facilitated by improper mitosis.
- **Age-related diseases:** Centrosome dysfunction, including potential anomalies in CEP63, is implicated in conditions such as cancer, neurodegenerative diseases, and developmental disorders, where abnormal cell division occurs.

### 3. Drug Interactions:
While specific drug interactions targeting CEP63 directly might not be well-established, drugs that target proteins involved in mitotic processes (e.g., microtubule-targeting agents like taxanes and vinca alkaloids) may affect CEP63 function indirectly:

- **Taxanes (e.g., Paclitaxel)**: Stabilize microtubules and affect normal spindle assembly processes, potentially influencing the role of proteins like CEP63 during cell division.
- **Vinca Alkaloids (e.g., Vincristine)**: Disrupt microtubule polymerization and could indirectly impact centrosomal function.

### 4. Pathways and Biological Processes:
CEP63 is involved in several essential biological processes and pathways, including:

- **Centrosome duplication**: Essential for proper cell division and ensuring the fidelity of chromosome segregation.
- **Microtubule organization**: Vital for the assembly and function of the mitotic spindle during cell division.
- **DNA damage response**: Participates in the cellular response to DNA damage; redistribution upon DNA damage indicates a regulatory role in mitosis.
- **Cell Cycle Regulation**: Involvement in processes that ensure proper progression through the cell cycle phases, particularly G2/M transition.
- **Spindle Assembly Checkpoint**: Coordinates the correct attachment of microtubules to kinetochores, impacting mitotic progression.

### Conclusion:
The CEP63 gene is crucial for proper centrosome function, mitotic fidelity, and DNA damage responses. Its interactions with various other proteins underscore its integrative role in cellular processes, with implications in aging and age-related diseases. Understanding its pathways and potential therapeutic targets continues to be an essential area of research within cell biology and oncology.