### Overview of SNORD114-2 Gene

**Gene Symbol:** SNORD114-2  
**Gene Type:** Small nucleolar RNA (snoRNA)

The SNORD114-2 gene belongs to the family of small nucleolar RNAs, specifically classified as a C/D box snoRNA. These types of snoRNAs are primarily involved in the modification of ribosomal RNA (rRNA) and are essential for the biogenesis of ribosomes.

### 1. Associated Genes

While specific gene associations for SNORD114-2 may not be extensively documented in public databases like NCBI or UniProt, small nucleolar RNAs often interact with several target genes involved in ribosome biogenesis and rRNA modification. Depletion or alterations in snoRNAs can impact ribosomal RNA synthesis and processing, which may indirectly affect the expression and function of ribosomal protein genes. However, comprehensive associations with other genes require detailed experimental validation, often through high-throughput studies in transcriptomics or genomics.

### 2. Aging and Age-Related Diseases

Research into the specific role of SNORD114-2 in aging or age-related diseases is relatively limited:

- **Aging:** Some studies investigating the roles of snoRNAs in general have hinted at their involvement in cellular senescence and ribosome production, which may contribute to aging. Dysregulation of ribosomal biogenesis has been linked to age-associated decline in cellular function.
  
- **Age-Related Diseases:** While direct links of SNORD114-2 to specific diseases are not well-established, alterations in snoRNA expression are increasingly being implicated in various health conditions, including cancers and neurodegenerative diseases. Further studies would be required to establish any direct correlations.

### 3. Drug Interactions

There are no specific drugs or drug classes that have been explicitly documented to interact with SNORD114-2 directly. However, given the role of snoRNAs in ribosome biogenesis, drugs that affect ribosomal function (like some antibiotics) might indirectly influence the expression of snoRNAs, including SNORD114-2. Research is ongoing, and more detailed investigations will be needed to characterize potential pharmacological interactions.

### 4. Pathways and Biological Processes

SNORD114-2 participates in several critical biological processes, primarily related to ribosome biogenesis. Key pathways include:

- **Ribosomal RNA Processing:** Involvement in the methylation and processing of pre-rRNA, enhancing ribosome functionality.
- **Gene Expression Regulation:** Facilitates the formation of mature ribosomes necessary for protein synthesis.
- **Cellular Growth and Proliferation:** Plays a crucial role in the overall process of cellular growth, as ribosome production is vital for translation and cell division.

### Conclusion

While the full implications of SNORD114-2 in health and disease are still being elucidated, it is primarily recognized for its role in ribosomal RNA modification and the broader implications it may have in cellular homeostasis, growth, and potentially aging. Continued research will help clarify its functions and associations with various biological processes and diseases.