### FBXW4 Gene Overview

**Gene Symbol**: FBXW4  
**Location**: Chromosome 4

#### 1. Associated Genes
FBXW4 has been studied in relation to various other genes implicated in limb development and related disorders. Notably, it may interact with:
- **SHH (Sonic Hedgehog)**: Involved in limb patterning; mutations can lead to limb malformations similar to those associated with FBXW4.
- **WNT Pathway Genes**: Involvement in the Wnt signaling pathway suggests interaction with genes such as **CTNNB1 (β-catenin)**.
- Genes related to **ubiquitination and proteasome pathways** often interact with FBXW4, given its role in protein degradation.

#### 2. Aging and Age-Related Diseases
While specific studies directly linking FBXW4 with aging are limited, its role in ubiquitination suggests potential implications in age-related cellular processes. Disruption in the ubiquitin-proteasome system has been associated with various age-related diseases, including:
- **Neurodegenerative Diseases**: Proteins accumulated due to impaired degradation might contribute to pathologies seen in disorders like Alzheimer’s and Parkinson’s.
- **Cancer**: FBXW4's role in protein degradation could influence oncogenic pathways, as altered protein turnover is a hallmark of many cancers.
- It may also have indirect associations with age-related skeletal diseases, given its involvement in limb development and proper skeletal formation.

#### 3. Drug Interactions
Currently, there are no specific drugs or drug classes directly known to interact with the FBXW4 gene. However, it might be implicated in pathways modulated by:
- **Proteasome inhibitors** (e.g., Bortezomib), which could indirectly affect cellular processes FBXW4 participates in.
- Drugs targeting **Wnt signaling** pathways may also be indirectly associated due to FBXW4's involvement in these canonical pathways.

#### 4. Biological Processes and Pathways
FBXW4 is involved in several key biological processes, including:
- **Protein Ubiquitination**: It functions as an E3 ubiquitin ligase within the ubiquitin-proteasome system, marking proteins for degradation.
- **Limb Development**: FBXW4 is crucial for normal limb morphogenesis as indicated by its phenotype similarity to split hand-split foot malformation.
- **Wnt Signaling Pathway**: FBXW4 may participate in this pathway, influencing developmental processes through modulation of signal transduction.
- **Cell Cycle Regulation**: Its role in ubiquitination may have downstream effects on cell cycle progression and regulation.

In summary, FBXW4 is a vital gene in several developmental pathways with implications in limb morphogenesis and potential associations with age-related diseases, while its precise connections to pharmacological agents remain to be extensively characterized. Further research may shed light on its role in cellular processes and human diseases.