### Gene Summary: PPP2R5C

**Gene Symbol:** PPP2R5C  
**Gene Product:** Regulatory subunit B56 gamma of Protein Phosphatase 2A (PP2A)

#### Overview
The PPP2R5C gene encodes a member of the B56 regulatory subunit family for protein phosphatase 2A (PP2A), an important serine/threonine phosphatase involved in a variety of cellular processes, including cell growth and division. The protein product is implicated in modulating substrate selectivity and catalytic activity, directing the localization of PP2A to specific cellular compartments. Additionally, it plays a critical role in the regulation of pathways like the cell cycle and apoptosis.

### 1. Associated Genes
While the summaries do not list any specific associated genes, the following genes are frequently discussed in conjunction with PPP2R5C due to overlapping functions and cellular interactions:
- **TP53**: Often co-regulated in pathways related to tumor suppression and DNA damage response.
- **ERK1/2 (MAPK)**: Involved in the MAPK/ERK signaling pathway, which is modulated by PPP2R5C through dephosphorylation.

### 2. Aging and Age-Related Diseases
Studies have shown that the dysregulation of PP2A, including its regulatory subunits like PPP2R5C, is associated with various age-related diseases, particularly cancer. Its role in dephosphorylating and activating TP53 suggests that alterations in PPP2R5C could influence cellular senescence and tumorigenesis. Additionally, changes in PP2A activity may contribute to neurodegenerative diseases such as Alzheimer's, where aberrant signaling pathways are implicated.

### 3. Drug Interactions
While specific drugs targeting PPP2R5C directly are not commonly documented, it is worth noting that various drugs impacting the PP2A pathway can indirectly affect its activity. Here are a few drug classes known to interact with the PP2A regulatory mechanisms:
- **Cancer therapeutics**: Some drugs, such as those targeting specific signaling pathways (e.g., inhibitors of the ERK pathway or upstream activators), may influence PP2A activity as a secondary effect.
- **Neuroprotective agents**: Drugs that affect the balance of phosphorylation states within cells may also indirectly impact PPP2R5C functionality, but specific drug interactions are under research.

### 4. Pathways and Biological Processes
PPP2R5C is involved in several key biological processes:
- **Cell Cycle Regulation**: Regulation of progression through the cell cycle by modulating phosphorylation states of key regulatory proteins.
- **Apoptosis**: Influencing apoptotic pathways, particularly through the regulation of TP53 activity.
- **MAPK Signaling Pathway**: Regulating the ERK pathway by dephosphorylating ERK proteins.
- **DNA Damage Response**: Modulating cellular responses to DNA damage, thereby impacting cellular stability and proliferation.

### Conclusion
PPP2R5C plays a crucial regulatory role within protein phosphatase 2A complexes and is integral to several signaling pathways critical for maintaining cellular homeostasis. Its implications in cancer biology and age-related diseases highlight the importance of further research into its functional mechanisms and potential therapeutic targets.