### FKBP1B Gene Overview

**Gene Symbol**: FKBP1B  
**Location**: Chromosome 10 (10q23.33)  
**Protein Type**: Immunophilin, Prolyl isomerase  

FKBP1B encodes a protein that is part of the immunophilin family, which play critical roles in immunoregulation, protein folding, and trafficking. It acts as a cis-trans prolyl isomerase and is similar to FKBP1A in function. FKBP1B binds to the immunosuppressive drugs FK506 and rapamycin, contributing to their physiological effects, including immunosuppression and potential toxicity.

### 1. Associated Genes
While specific interactions and associations can depend on context, FKBP1B has been studied in connection with several genes and proteins involved in cell signaling and immune response, including:
- **FKBP1A**: Another member of the FKBP family, highly similar in structure and function.
- **mTOR (Mechanistic Target of Rapamycin)**: A pathway where FKBP1B, through its interaction with rapamycin, plays a critical role.
- **Calcineurin (PPP3CA)**: Involved in signaling pathways where immunophilins are active regulators.

### 2. Aging and Age-Related Diseases
Research indicates that FKBP1B may play a role in the regulation of heart function and cellular stress responses. Alterations in excitation-contraction coupling in cardiac muscle can contribute to age-related cardiac dysfunction. Furthermore, as FKBP1B interacts with immunosuppressants which may influence immune senescence, it could have indirect implications in age-related diseases such as cancer and autoimmune disorders.

### 3. Drug Interactions
FKBP1B is known to interact with the following drugs and drug classes:
- **Immunosuppressants**:  
  - **FK506 (Tacrolimus)**: Used primarily in organ transplantation to prevent rejection.
  - **Rapamycin (Sirolimus)**: Also used in transplant medicine and has implications in cancer therapy.
- **Cyclophilin inhibitors**: Although mainly related to another family of proteins, there is some overlap in the biological effects with FKBP proteins.
- **Potential interactions with drugs targeting mTOR pathways**, given its role in protein synthesis, cell growth, and proliferation.

### 4. Pathways and Biological Processes
FKBP1B is involved in several key biological processes and pathways:
- **Protein Folding and Trafficking**: Functions as a chaperone that assists in the proper folding of proteins.
- **Immune Response**: Modulates the effects of immunosuppressive agents and contributes to the regulation of T-cell activation.
- **Muscle Contraction**: Particularly involved in excitation-contraction coupling in cardiomyocytes, affecting cardiac function.
- **mTOR Signaling Pathway**: Through its binding with rapamycin, FKBP1B alters cellular growth and metabolism.
- **Calcium Signal Transduction**: As it is involved in cardiomyocyte function, FKBP1B has interaction points in calcium signaling pathways.

### Summary
FKBP1B is a critical gene in the context of both cellular processes and pharmacological interactions, particularly concerning immunosuppressive therapies and cardiac physiology. Its implications in aging, particularly concerning heart health and immune function, underline its significance in both basic research and clinical contexts.