### USP17L3 Gene Overview
**Gene Symbol:** USP17L3 (Ubiquitin Specific Peptidase 17-Like 3)

**Function:** The USP17L3 gene encodes a deubiquitinating enzyme that primarily functions to remove ubiquitin from substrates, thereby regulating various cellular functions, including signal transduction, apoptosis, and cell cycle progression. This gene is predicted to play a role in processes like protein deubiquitination and the regulation of apoptosis.

### 1. Associated Genes
While the specific NCBI and UniProt summaries do not list associated genes, USP17L3 may be functionally associated with other deubiquitinating enzymes (DUBs) like USP17, USP7, and UCHL1, which play crucial roles in ubiquitin signaling pathways. Additionally, genes involved in apoptosis and cell cycle progression, including TP53, BAX, and CDK inhibitors, may also be linked through relevant pathways.

### 2. Aging and Age-Related Diseases
Currently, there are limited direct studies specifically linking USP17L3 to aging or age-related diseases. However, as USP17L3 is involved in apoptosis and cellular stress responses, its dysregulation may be indirectly associated with age-related cellular processes such as cellular senescence, neurodegeneration, and cancers that are more prevalent with advancing age due to accumulation of mutations and altered signaling. The regulation of apoptosis by USP17L3 suggests a potential involvement in age-related disorders like Alzheimer's disease and other neurodegenerative conditions, though further research is essential to clarify these connections.

### 3. Drug Interactions
To date, specific drugs or drug classes directly known to interact with USP17L3 have not been extensively studied or characterized. However, given USP17L3’s role in deubiquitination, it is possible that inhibitors of deubiquitinating enzymes, including small molecules designed to modulate DUB activity, could affect its function. Research on deubiquitinase inhibitors (like those targeting USP7 or USP14) may provide insights into potential drug interactions, but no specific interactions for USP17L3 have been conclusively documented.

### 4. Pathways and Biological Processes
USP17L3 is involved in numerous biological processes and pathways, including:
- **Protein Ubiquitination and Deubiquitination:** The primary pathway, in which USP17L3 removes ubiquitin moieties from proteins, affecting their stability and function.
- **Apoptosis:** The regulation of programmed cell death, where USP17L3 may influence both pro-apoptotic and anti-apoptotic signals.
- **Cell Cycle Regulation:** Influencing progression through different phases of the cell cycle, potentially through protein stabilization or degradation.
- **Immune Response:** There is potential involvement in innate immune responses, particularly regarding the cellular response to viral infections.
- **Signaling Pathways:** USP17L3 may modulate various signaling cascades, including those related to cell migration and proliferation.

### Summary
In summary, USP17L3 is a predicted deubiquitinating enzyme that plays essential roles in protein regulation, apoptosis, and cell cycle processes. Its potential connections to other genes, age-related processes, and specific drug interactions warrant further investigation to fully understand its biological significance and therapeutic potential.