### ME2 Gene Overview 

#### Basic Information
- **Gene Symbol:** ME2
- **Gene Description:** The ME2 gene encodes a mitochondrial NAD-dependent malic enzyme that is responsible for the oxidative decarboxylation of malate to pyruvate. The enzyme functions as a homotetramer and plays a vital role in cellular metabolism, particularly in the tricarboxylic acid (TCA) cycle.

#### 1. Associated Genes
While the ME2 gene itself is specifically noted, it is often studied in the context of metabolic pathways and conditions associated with energy metabolism. However, it is directly associated with a few genes:
- **SLC25A11:** This gene encodes a mitochondrial dicarboxylate carrier protein that may interact with ME2 in metabolic processes.
- **GPD2 (Glycerol-3-phosphate dehydrogenase 2):** This enzyme is involved in glycerol phosphate metabolism and may share metabolic interactions with ME2.
- **IDH3A:** The isocitrate dehydrogenase gene might also be linked in studies examining mitochondrial metabolism and energy homeostasis.

#### 2. Aging and Age-Related Diseases
Although direct associations with aging or age-related diseases are not extensively documented, mitochondrial function plays a critical role in aging processes:
- Mitochondrial malic enzymes like ME2 may contribute to age-related decline in cellular metabolism.
- Alterations in metabolic pathways including those involving ME2 may indirectly relate to age-related diseases such as neurodegenerative diseases and metabolic syndromes.
- Potential implications in disorders associated with energy dysregulation, such as Type 2 Diabetes, which are often seen in aging populations.

#### 3. Drug Interactions
Currently, specific pharmacological agents that directly target the ME2 enzyme have not been extensively characterized. However, general classes of compounds might interact with its metabolic pathways:
- **Antioxidants:** Since ME2 is involved in redox reactions, antioxidants could indirectly influence its activity by modulating oxidative stress within the mitochondria.
- **Metformin:** This common diabetes medication might influence cellular energy metabolism, including pathways involving malic enzymes, although not specifically tested on ME2.

#### 4. Pathways and Biological Processes
The ME2 gene participates in several important biological pathways:
- **Citrate Cycle (TCA Cycle):** ME2 plays a crucial role in cellular respiration and energy metabolism.
- **Malate-aspartate shuttle:** Involved in transport mechanisms that facilitate the production of NADH for oxidative phosphorylation, linking mitochondrial and cytosolic metabolism.
- **Regulation of NAD(P)H levels:** It helps balance the cellular redox state, impacting various metabolic processes.
- **Brain metabolism:** ME2 has a suggested role in metabolic pathways specific to neuronal function and health, particularly in the context of epilepsy connected to SNPs within the gene.

In summary, the ME2 gene encodes a key mitochondrial enzyme involved in energy metabolism, with possible implications in metabolic disorders, aging research, and certain genetic associations. Further studies could elucidate its role in specific diseases and potential therapeutic interactions.