### DENND2C Gene Overview

**Gene Name:** DENND2C  
**Gene Symbol:** DENND2C  
**Enzymatic Function:** Guanine nucleotide exchange factor (GEF)  
**Key Activity:** Activates RAB9A and RAB9B by promoting GDP to GTP exchange.

### Additional Information

1. **Associated Genes:**
   - Although specific interactions for DENND2C may not be detailed outside of what is found in NCBI and UniProt, it is associated with several RAB genes aside from RAB9A and RAB9B, particularly:
     - **RAB9A**: Involved in retrograde transport.
     - **RAB9B**: Similar role in endosomal transport.
     - Other RAB proteins that may relate to vesicle trafficking could be indirectly associated.

2. **Aging and Age-related Diseases:**
   - While specific studies directly linking DENND2C to aging or age-related diseases are limited, the protein functions within the cellular transport systems which may be impacted by aging processes. Dysfunctional vesicle trafficking is often observed in neurodegenerative diseases and can lead to accumulation of toxic proteins. Moreover, aberrations in RAB proteins have been implicated in conditions like Alzheimer's and Parkinson’s diseases, which are oftentimes associated with aging.

3. **Drug Interaction:**
   - Currently, direct pharmacological compounds or drug classes that specifically target DENND2C are not well-documented in the literature. However, given its role in GTPase regulation and vesicle transport, potential indirect interactions could be noted with drugs influencing RAB proteins or broader cellular trafficking mechanisms (i.e., antifungal drugs targeting rab proteins, some anticancer therapeutics). Further studies would be required to clarify any pharmacological relationships.

4. **Pathways and Biological Processes:**
   - DENND2C is involved in several key biological processes:
     - **Protein transport and vesicular trafficking**: Plays a role in the membrane dynamics and intracellular transport by activating RAB proteins, which are pivotal in the delivery of proteins and lipids within the cell.
     - **Endosomal transport**: Facilitates the proper transport of material in the endosomal pathway.
     - **Regulation of protein activity**: By converting GDP-bound RAB proteins into their active GTP-bound forms, it regulates various downstream signaling pathways influenced by these small GTPases.
     - **Cellular response to stimuli**: May play a role in how cells respond to various external signals, relevant in both normal physiological processes and disease states.

### Conclusion
DENND2C is an important GEF with key roles in regulating RAB proteins and thus plays a central role in cellular transport. Its potential implications in aging and diseases associated with dysfunctional vesicular trafficking make it an interesting target for further research. However, more comprehensive studies are needed to elucidate its specific roles, particularly regarding drug interactions and direct associations with age-related pathologies.