### AGBL3 Gene Overview

**Gene Symbol:** AGBL3  
**Entrez Gene ID:** 7384  
**NCBI Gene Summary:** The AGBL3 gene encodes a protein known to have metallocarboxypeptidase activity, specifically involved in the process of protein side chain deglutamylation. It is primarily localized in the cytosol. The protein product is recognized for its ability to mediate the removal of polyglutamate side chains from the C-terminal tail of tubulin and may also deglutamylate non-tubulin proteins.

### 1. Associated Genes
While specific direct associations aside from MYLK (myosin light chain kinase) are not detailed in the provided summaries, AGBL3 may have interactions with other glutamate-related signaling proteins. Genes in the tubulin family or those involved in microtubule dynamics may also interact indirectly due to the role of AGBL3 in tubulin modification. Some potential associated genes might include:

- **TUBA1A**: Tubulin alpha-1A chain
- **TUBB**: Tubulin beta chain
- **TUBB2A**: Tubulin beta-2A chain
- Proteins involved in microtubule assembly or disassembly.

### 2. Aging and Age-Related Diseases
Current literature does not provide extensive information indicating a direct link between AGBL3 and aging or specific age-related diseases. However, given the role of microtubules in cellular structure and function, dysregulation of deglutamylation processes mediated by AGBL3 could contribute to cellular aging, neurodegenerative diseases, and other conditions associated with cellular function over time. For instance, a link has been suggested between tubulin modifications and neurodegeneration processes in some studies, although not specifically pinpointed to AGBL3.

### 3. Drug Interactions
As of the latest available data, there are no prominent drugs or drug classes specifically known to interact with AGBL3. However, due to its role in protein modification and microtubule dynamics, indirect effects from drugs affecting cytoskeletal functions, such as certain chemotherapeutics (e.g., taxanes), might be of relevance.

### 4. Pathways and Biological Processes
AGBL3 is involved in pathways related to:

- **Cytoskeletal organization**: Through its role in deglutamylation of tubulin, AGBL3 contributes to microtubule dynamics and stability.
- **Protein metabolism**: Being a metallocarboxypeptidase, AGBL3 is part of post-translational modification processes affecting protein function.
- **Signal transduction**: This gene may indirectly participate in cellular signaling by modifying interactions of various proteins linked through glutamylation.

In conclusion, AGBL3 plays a critical role in modulating protein structures through the removal of polyglutamate side chains, impacting cellular processes linked to the cytoskeleton. Further research is warranted to elucidate its roles in aging and disease mechanisms more definitively.