### SEMA3C Gene Overview

**Gene Symbol**: SEMA3C  
**Gene Description**: SEMA3C encodes a secreted glycoprotein that is part of the semaphorin class 3 family, which consists of neuronal guidance cues crucial for the proper development of the nervous system and other physiological processes.

### 1. Associated Genes
While the summaries highlight interactions with neuropilins and plexins, SEMA3C may also be associated with several other genes through pathways related to neuronal patterning and cancer progression. Some of these include:

- **TP53** (Tumor protein p53): Involved in various cellular processes, including regulation of the cell cycle.
- **RHOA** (Ras homolog family member A): Plays a role in regulating the cytoskeletal dynamics and cell motility which can be influenced by SEMA3C signaling.
- **VEGFA** (Vascular endothelial growth factor A): It is involved in angiogenesis, and SEMA3C can have downstream effects on vascular formation.

### 2. Aging and Age-Related Diseases
Research indicates that alterations in SEMA3C expression can be linked to age-related pathologies, particularly in cancer physiology. Some specific implications include:

- **Cancer**: Increased SEMA3C expression is associated with enhanced tumor invasiveness and metastasis. Indeed, this gene's expression may change in various cancers with age, emphasizing its potential role in tumor progression.
- **Neurodegeneration**: Given its role in neuronal pathways, any dysregulation may lead to increased neurodegenerative processes, although specific mechanisms in aging have not been thoroughly defined.

### 3. Drug Interactions
While direct drug interactions with SEMA3C may not be robustly characterized, several classes of drugs and compounds that target pathways involving SEMA3C signaling might include:

- **Tyrosine Kinase Inhibitors**: These are frequently used in cancer therapies, which may modulate pathways influenced by SEMA3C.
- **Cytokine modulators** and **anti-angiogenics** could also influence signaling pathways that are affected by SEMA3C.

No specific drugs have been documented exclusively interacting with SEMA3C; however, it is reasonable to anticipate interactions within therapeutic contexts concerning tumors and neural pathologies.

### 4. Pathways and Biological Processes
SEMA3C is involved in several key biological pathways, including:

- **Axon Guidance Pathway**: Key role in directing the growth cones of neurons during development.
- **Semaphorin signaling**: Plays a critical role in various processes related to neuronal development and vascular development.
- **Cell Adhesion and Migration**: Modulates cell adhesion dynamics, impacting cancer metastasis and vascularization processes.
- **Cardiovascular Development**: Critical for proper development of the cardiovascular system in embryogenesis.

### Summary
The SEMA3C gene is essential for neuronal guidance and proper cardiovascular development, with significant implications in cancer biology. Its associations with other genes and pathways underline its multifaceted roles in both development and disease processes, while its interactions with therapeutics may offer insights into potential targeted treatments. Further research into SEMA3C will likely unveil additional connections to aging and other diseases.