### INTS13 Gene Overview

**Gene Symbol:** INTS13  
**Nuclear Location:** Cytoplasm and nuclear body  
**Function:** INTS13 is a crucial regulator of the mitotic cell cycle and has important roles during various stages of cell division. It is involved in several cellular processes, including centrosome localization, mitotic spindle organization, and protein localization to the nuclear envelope. Specifically, it anchors dynein to the nuclear envelope during prophase, which is vital for the proper coupling between the centrosome and the nucleus. During the G2/M phase, INTS13 is implicated in proper spindle formation and the execution of cytokinesis. Additionally, it is a probable component of the Integrator (INT) complex, which is involved in the transcription of small nuclear RNAs (snRNAs) U1 and U2 and their 3'-box-dependent processing.

### 1. Associated Genes
While specific genes directly associated with INTS13 are not always highlighted in every summary, genes potentially linked through pathways and functions include:
- **DYNC1H1**: As INTS13 is involved in dynein anchoring, this gene’s product is critical for dynein activity.
- **KIF11**: This gene encodes a motor protein that may interact with spindle apparatus components during mitosis.
- **CENPA**: Related to centromere function and possibly influencing INTS13's roles in mitotic processes.

### 2. Aging and Age-Related Diseases
Research into the role of INTS13 in aging and age-related diseases is still developing, but several relevant points can be noted:
- **Cell Division and Aging**: Dysregulated mitotic processes are often implicated in aging. As INTS13 plays a crucial role in cell cycle regulation, mutations or dysregulation could potentially contribute to age-associated diseases like cancer.
- **Neurodegeneration**: In cases of age-related neurodegenerative diseases, proper cell division and maintenance of cellular components are critical. Altered functions of genes like INTS13 might be linked to accumulated cellular damage over time.

### 3. Drug Interactions
Specific drugs directly interacting with INTS13 have not been extensively characterized, as it is often studied within the context of broader processes:
- **Antineoplastic agents**: Given that dysregulation of INTS13 can lead to concerns in cancer biology, drugs commonly targeting the cell cycle (like taxanes or spindle poisons) may indirectly influence the pathways involving INTS13.
- **Antiviral agents**: Some studies suggest interactions with viral processes where INTS13's role in RNA metabolism could be relevant.

### 4. Pathways and Biological Processes
INTS13 is involved in several critical biological pathways:
- **Cell Cycle Regulation**: Critical during the G2/M transition, spindle assembly, and cytokinesis.
- **Mitotic Phase Transition**: Helps in the transition through different phases of mitosis by ensuring proper chromosomal separation.
- **RNA Processing**: As part of the Integrator complex, INTS13 is involved in snRNA transcription, functioning within the transcription machinery, affecting mRNA processing and stability.
- **Centrosome Dynamics**: By anchoring dynein to the nuclear envelope, it plays a role in centrosome and microtubule dynamics essential for accurate cell division.

### Conclusion
In summary, INTS13 is a significant gene influencing cellular division and development, with potential implications in aging and diseases like cancer. Its interactions and pathways indicate an essential role in maintaining genomic integrity through regulated cell cycle progression and RNA processing activities. Further research may uncover more about its direct associations and implications for health and disease.