### ASB15-AS1 Gene Overview

**Gene Symbol:** ASB15-AS1

ASB15-AS1 (ASB15 Antisense RNA 1) is an lncRNA (long non-coding RNA) gene located on human chromosome 1. The gene is implicated in various biological processes and has potential regulatory roles in gene expression.

### 1. Associated Genes

Beyond the summaries provided by NCBI and UniProt, ASB15-AS1 is associated with several genes. Some of the key genes that have been linked with ASB15-AS1 include:

- **ASB15:** The sense estrangement of ASB15-AS1, which is also part of the Ankyrin Repeat and SOCS Box protein family, is known to be involved in protein degradation and signal transduction.
- **FOS:** This gene is involved in cell proliferation and differentiation.
- **IL6:** Known for its role in inflammation and immune responses.
- **TNF:** A cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction.

### 2. Aging and Age-related Diseases

Research on ASB15-AS1 suggests that alterations in its expression may have implications in age-related diseases. While specific studies directly linking ASB15-AS1 to aging are limited, lncRNAs in general have been implicated in processes associated with senescence and cellular aging. Notably, ASB family proteins, such as ASB15, have been shown to play roles in regulatory networks that influence inflammation, oxidative stress response, and cellular senescence, which are critical in age-related pathologies such as:

- **Cardiovascular diseases**
- **Neurodegeneration**
- **Cancers**

### 3. Drug Interactions

Current literature does not show direct interactions with specific drugs or drug classes for ASB15-AS1. However, given its association with pathways related to inflammation and cell regulation, it is plausible that compounds targeting inflammation (anti-inflammatory drugs) or cancer therapies might indirectly influence ASB15-AS1 expression or function.

### 4. Pathways and Biological Processes

ASB15-AS1 is involved in various biological processes, which may include:

- **Gene Regulation:** Involved in epigenetic regulation, possibly modulating gene expression through interactions with chromatin-modifying complexes.
- **Cellular Response to Stress:** Participation in cellular stress response pathways, particularly in the context of inflammation and oxidative stress.
- **Signal Transduction Pathways:** Potentially influences pathways related to immune responses and cellular growth, similar to that of other lncRNAs.

Moreover, lncRNAs often serve as scaffolds for protein complexes or competing endogenous RNAs (ceRNAs), which can lead to the modulation of mRNA expression levels of associated genes, although the precise mechanisms are still being elucidated.

### Summary

ASB15-AS1 represents a significant member of the lncRNA family, associated with multiple genes involved in critical biological processes and potentially tied to age-related mechanisms. Further research is necessary to fully understand its role and impact on both health and disease.