### MTHFSD Gene Overview

**Gene Symbol:** MTHFSD  
**Function:** The MTHFSD gene encodes a protein that exhibits RNA binding activity and is predicted to be active in the cytoplasm. The gene is potentially involved in the metabolism of folate and may play a role in one-carbon metabolism.

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### 1. Associated Genes

While the summaries do not list directly associated genes, members of the folate metabolism pathway may be indirectly relevant or associated with MTHFSD. Genes that are part of or interact within this pathway include:

- **MTHFR (Methylenetetrahydrofolate reductase):** This gene is crucial for converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.
- **DHFR (Dihydrofolate reductase):** Catalyzes the reduction of dihydrofolate to tetrahydrofolate.
- **FOLR1 (Folate receptor 1):** Mediates the transport of folate into cells.
- **SHMT1 (Serine hydroxymethyltransferase 1):** Critical for one-carbon metabolism.

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### 2. Aging and Age-Related Diseases

There is limited specific data on MTHFSD's direct links to aging or age-related diseases. However, given its role in folate metabolism, it may have implications for:

- **Neurodegenerative diseases:** Abnormal folate metabolism has been implicated in conditions such as Alzheimer's disease and Parkinson's disease.
- **Cardiovascular diseases:** Folate deficiency is associated with elevated homocysteine levels, which is a risk factor for cardiovascular ailments.

Further research is needed to establish direct correlations between MTHFSD and specific aging-related conditions.

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### 3. Drugs or Drug Classes Interacting with MTHFSD

While direct interactions may not be documented specifically for MTHFSD, the following classes of drugs are relevant, as they relate to the metabolic pathways where MTHFSD might play a role:

- **Folate Supplements:** Such as folic acid, which support normal folate levels and may indirectly influence MTHFSD function.
- **Antimetabolites:** Like methotrexate, which interacts with folate metabolism, may have secondary effects on enzymes influenced by MTHFSD.

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### 4. Pathways and Biological Processes

MTHFSD is believed to participate in several biological pathways:

- **One-carbon metabolism:** Involves pathways connecting folate, amino acids (like serine and glycine), and nucleotides, impacting DNA synthesis and methylation.
- **Amino acid metabolism:** Particularly in the interconversion of serine and glycine within the context of folate metabolism.
- **Tetrahydrofolate biosynthesis:** A pathway critical to the synthesis and recycling of active folate forms.

These pathways are crucial for cellular function, growth, and maintenance, emphasizing the potential significance of MTHFSD's activity.

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### Summary

The MTHFSD gene plays a vital role in RNA binding and is implicated in one-carbon and folate metabolism. While more research is needed to understand its direct associations with aging and age-related diseases, it is involved in critical metabolic pathways that can have broader implications for health. The gene interfaces with other key players in folate metabolism, and understanding its functions may provide insights into therapeutic interventions related to metabolic disorders.