### NUP107 Gene Overview

**Gene Symbol:** NUP107  
**Location:** The NUP107 gene is located on chromosome 2 in humans.  
**Protein Product:** The gene encodes a protein that is a member of the nucleoporin family, known for forming the nuclear pore complex (NPC).

### 1. Associated Genes
NUP107 is known to interact with several other nucleoporins and proteins involved in nuclear transport. Some key associated genes include:

- **NUP62:** Known for anchoring to the nuclear pore complex and is crucial for nucleocytoplasmic transport.
- **NUP43:** Another member of the nucleoporin family that participates in the formation of the nuclear pore.
- **NUP133:** Has a structural role in the nuclear pore complex and interacts with NUP107 in NPC assembly.
- **NUP96:** Another nucleoporin involved in the structural integrity of the nuclear pore complex.
- **NUP155:** Essential for the NPC assembly and may have roles in specific transport functions.

### 2. Aging and Age-related Diseases
While direct associations of NUP107 with aging are not prominently established in the literature, nucleoporins, including NUP107, have been implicated in processes such as:

- **Cellular Senescence:** Disruption in nuclear transport processes can lead to cellular senescence, a hallmark of aging.
- **Neurodegenerative Diseases:** Alterations in NPC function can be linked to neurodegenerative conditions, as seen in diseases like Alzheimer’s and Huntington’s, where nuclear transport is compromised.
- **Cancer:** Mutations or dysregulation of nucleoporins can contribute to oncogenesis, impacting cellular turnover and aging processes.

### 3. Drug Interactions
Currently, no specific drugs or drug classes are universally recognized for direct interaction with the NUP107 protein. However, research indicates that some compounds aimed at modulating nuclear transport could indirectly influence the function of NUP107 through effects on the nuclear pore complex, such as:

- **Leptomycin B:** An inhibitor of nuclear export that can affect nucleoporin function.
- **Importin inhibitors:** These drugs affect nuclear transport and could have downstream effects on nucleoporins, including NUP107.

### 4. Pathways and Biological Processes
NUP107 is involved in critical biological processes:

- **Nuclear Pore Complex Assembly:** NUP107 is essential for the formation and stability of the NPC, allowing the regulated transport of molecules.
- **Nuclear Transport:** Facilitates the bidirectional transport of proteins and RNA between the nucleus and cytoplasm.
- **Nephrogenesis:** Research suggests that NUP107 plays a role in kidney development, influencing processes essential for nephron formation.
- **Cell Cycle Regulation:** The function of NUP107 may influence mitotic progression due to its role in nucleocytoplasmic transport.
- **Response to Stress:** NUP107 has been implicated in the cellular response to various stressors, including those affecting nuclear transport.

### Conclusion
NUP107 is a critical nucleoporin with roles extending from nuclear transport to developmental processes. While further studies are needed to elucidate its precise implications in aging and diseases, its functions within the nuclear pore complex underline its importance in cellular health and integrity.