### EHD3 Gene Overview

**Gene Symbol:** EHD3  
**Location:** This gene is located on human chromosome 16 and encodes for a protein that belongs to the EHD (EH domain-containing) family of proteins, which are evolutionarily conserved.

### 1. Associated Genes

In addition to the major genes mentioned in the summary, EHD3 has been associated with:

- **ANK2**: Ankyrin 2, involved in maintaining the structure and function of cardiac myocytes.
- **SLC8A1**: Sodium/calcium exchanger 1, involved in cardiac muscle contraction and rhythm.
- **CACNA1C** and **CACNA1H**: Subunits of voltage-gated calcium channels participating in cardiac excitability.
- **BACE1**: Beta-site amyloid precursor protein cleaving enzyme 1, important in amyloid-beta production associated with Alzheimer's disease.
- **KDR/VEGFR2**: Vascular endothelial growth factor receptor 2, involved in angiogenesis and vascular permeability.
- **Integrin beta-3**: Essential for cell adhesion and signal transduction.

### 2. Aging and Age-Related Diseases

While direct associations of EHD3 with aging or age-related diseases are not comprehensively documented, several pathways involving EHD3 are related to:

- **Cardiovascular Health**: EHD3's regulatory roles in cardiac proteins and membrane traffic may influence cardiac function as one ages, potentially implicating it in age-related cardiovascular diseases.
- **Neurodegenerative Diseases**: Its role in endocytic trafficking related to BACE1 suggests that EHD3 might be implicated in Alzheimer's disease, a common neurodegenerative condition associated with aging.
- **Ciliary Function & Aging**: Ciliopathy has been linked to various age-related disorders, suggesting that EHD3's involvement in ciliary vesicle formation might have implications for age-related ciliary dysfunction.

### 3. Drug Interactions

To date, specific drugs or drug classes that interact directly with EHD3 are not broadly recognized, but potential interactions may arise from its function in cellular transport related pathways, meaning pharmaceuticals that affect endocytosis and intracellular trafficking could have secondary effects on EHD3 functionality.

### 4. Pathways and Biological Processes 

EHD3 is involved in several biological processes and pathways, including:

- **Endosomal Transport**: Facilitating the transport between early endosomes, recycling endosomes, and the Golgi apparatus.
- **Membrane Dynamics**: ATP-dependent reorganization of membranes, contributing to the formation and trafficking of tubules necessary for various cellular processes.
- **Ciliary Formation and Function**: Plays a role in the biogenesis of cilium, which is essential for signaling and sensory functions in cells.
- **Integrin Recycling**: Involved in the recycling mechanisms of integrins, crucial for maintaining cell adhesion and extracellular matrix interactions.
- **Dopaminergic and Cardiac Function**: Mediates the recycling of neurotransmitter receptors, such as D1 dopamine receptor, and is implicated in cardiac muscle cell membrane potential regulation.

Overall, EHD3 plays crucial roles in intracellular trafficking and membrane dynamics, particularly in neurons and cardiac tissues, with implications that may affect aging and related diseases through its influence on various cellular pathways. Further research may elucidate more precise roles and interactions relevant to pharmacological approaches.