### RNU6-828P Gene Overview

**Gene Symbol:** RNU6-828P  
**Gene Type:** Non-coding RNA (specifically, a small nuclear RNA, or snRNA)

RNU6-828P is a member of the U6 small nuclear RNA family, which plays an important role in the splicing of pre-mRNA. It is a part of the spliceosomal machinery, participating in the catalysis of intron removal from pre-mRNAs.

### 1. Associated Genes

While specific gene associations might not be widely documented in standard repositories, small nuclear RNAs like RNU6-828P are generally associated with various splicing factors and genes involved in mRNA processing. Some closely related genes involved in RNA splicing or affecting small nuclear RNA dynamics might include:

- **PRP8**: A core component of the spliceosome.
- **SNRNP70**: Part of the small nuclear ribonucleoprotein (snRNP) complexes.
- **SNRNP200**: Another spliceosomal component.
- **U5 and U4 small nuclear RNAs**: Involved in the splicing process.

### 2. Aging or Age-Related Diseases Associations

While specific details on RNU6-828P and its links to aging or age-related diseases are limited, in general, disruptions in RNA splicing have been implicated in various age-related diseases, such as:

- **Neurodegenerative disorders** (e.g., Alzheimer’s disease) that may involve issues with RNA processing and splicing factors.
- **Age-related cancers**, where misregulation of splicing variants can lead to oncogenesis.

The expression levels and functional integrity of snRNAs in general tend to decline with age, potentially leading to splicing abnormalities, which could suggest an indirect involvement of RNU6-828P in these processes.

### 3. Known Drug Interactions

Currently, there are no specific drugs or drug classes explicitly documented to interact with RNU6-828P. However, in a broader context, some drugs targeting splicing mechanisms, like spliceosome-modulating drugs for cancer treatment (e.g., E7107), may affect RNU6-828P's function, though this is not specifically confirmed for this particular snRNA.

### 4. Pathways and Biological Processes

RNU6-828P is primarily involved in the following pathways and biological processes:

- **mRNA Splicing**: Directly participates in the excision of introns from pre-mRNA transcriptions.
- **RNA processing**: Involved in modifications and maturation of small nuclear RNAs and other forms of RNA.
- **Regulation of Gene Expression**: Since splicing directly influences the protein-coding potential of mRNAs, RNU6-828P plays a critical role in the regulation of gene expression.

Additional details can depend on ongoing research and findings related to this non-coding RNA, as the functional nuances of these genes continue to be elucidated.