### CCDC113 Gene Overview

**Gene Symbol:** CCDC113  
**Entrez Gene ID:** 23349  
**Location:** Human chromosome 10q23.3  

**Function:** The CCDC113 gene encodes a protein that plays a crucial role in the assembly and maintenance of cilia, specifically contributing to the formation of primary cilia. This protein is located in centriolar satellites and ciliary basal bodies and is part of a protein complex necessary for proper ciliary function.

### Additional Gene Associations

1. **Related Genes:**
   - **CCDC139**
   - **CEP290**
   - **BBS4 (Bardet-Biedl syndrome 4)**
   - **IFT88 (Intraflagellar Transport 88)**
   - **KIF3A (Kinesin Family Member 3A)**
   These genes are involved in ciliary function, ciliary transport, and assembly, making them relevant for studies involving cilia-related biological processes and diseases.

### Aging and Age-related Diseases

- The CCDC113 gene is associated with primary ciliary dyskinesia (PCD) and other ciliopathies. Impaired ciliary function has been linked to various age-related disorders, including neurodegenerative diseases, respiratory diseases, and developmental anomalies. While research specific to CCDC113's role in aging is limited, its involvement in cilia-related processes suggests potential implications in age-related pathologies where cilia function degrades over time.

### Drug Interactions

- **Known Interactions:**
   - As of October 2023, there are no specific drugs or drug classes that are widely recognized to directly interact with CCDC113. However, broader investigations into compounds affecting ciliary assembly or function (e.g., certain cancer treatments, gene therapies targeting ciliary dysfunction) could potentially have implications for this gene indirectly.

### Pathways and Biological Processes

1. **Biological Processes:**
   - Cilium assembly and maintenance
   - Regulation of ciliary transport
   - Centriolar satellite organization

2. **Pathways:**
   - Hedgehog Signaling Pathway
   - Wnt/β-catenin signaling pathway
   - Signaling pathways involved in organ development, especially in organs where ciliated cells are prominent (e.g., lungs, kidneys).

### Summary

The CCDC113 gene plays a vital role in ciliary function, making it important for proper cellular signaling and physiological processes. Its associations with other ciliary-related genes underscore its importance in maintaining ciliary integrity, which can be crucial for respiratory and neurological health, especially in the context of aging and related diseases. Further research into therapeutic mechanisms targeting ciliary dysfunction may provide insights into the development of treatments for diseases associated with ciliary abnormalities.