### Overview of SNORD114-27 Gene

**Gene Symbol**: SNORD114-27  
**Type**: Small nucleolar RNA (snoRNA)

The SNORD114-27 gene encodes a member of the small nucleolar RNA (snoRNA) family, which is primarily involved in the modification of other RNAs, mainly rRNA (ribosomal RNA). It is part of the C/D box snoRNAs that function in 2'-O-ribose methylation.

### 1. Associated Genes

Although specific associations of SNORD114-27 with other genes may not be explicitly documented in standard databases, snoRNAs are often found within clusters that may interact with or regulate neighboring genes. In the case of SNORD114-27, it belongs to the SNORD114 gene cluster located on chromosome 14, which contains multiple snoRNA genes. Other snoRNAs within this cluster may share regulatory functions or be involved in similar cellular processes.

### 2. Aging or Age-Related Diseases

Current knowledge regarding SNORD114-27 and its direct role in aging or age-related diseases is limited. However, snoRNAs, including SNORD114-27, have been implicated in various biological processes that could be related to cellular aging, such as the regulation of ribosome biogenesis and RNA processing. Altered expression of snoRNAs has been noted in various age-related pathologies, which might suggest a potential indirect relationship between SNORD114-27 and age-related cellular functions or diseases.

### 3. Drug Interactions

As of the current data available, there are no specific drugs or drug classes documented to directly interact with SNORD114-27. snoRNAs typically do not serve as drug targets themselves but may influence cellular pathways that could be pharmacologically relevant. Generally, drugs affecting ribosome synthesis or RNA processing might indirectly influence the functional activity of snoRNAs.

### 4. Pathways and Biological Processes

SNORD114-27 is associated with the following pathways and biological processes:

- **Ribosome Biogenesis**: It plays a role in the chemical modification of rRNAs critical for the formation of functional ribosomes.
- **2'-O-Ribose Methylation**: It is involved in the methylation of specific nucleotides of rRNA, a modification that influences RNA stability and function.
- **Nuclear RNA Processing**: The snoRNA may influence splicing and processing of precursor rRNAs within the nucleolus.
  
Furthermore, snoRNAs can be associated with broader cellular functions including proliferation, differentiation, and stress responses, which can relate indirectly to aging and the maintenance of cellular homeostasis.

### Summary

SNORD114-27 is a snoRNA involved in critical post-transcriptional modifications of rRNA, contributing to ribosome biogenesis and overall gene expression regulation. While direct connections to aging or drugs remain unclear, its involvement in fundamental cellular processes lays the groundwork for potential links to age-related changes or conditions. Continued research in snoRNA biology may illuminate more nuanced interactions and implications for health and disease over time.