### NBEAL1 Gene Overview

**Gene Symbol:** NBEAL1  
**Entrez Gene ID:** 156067  
**Location:** Chromosome 4

**Function:** The NBEAL1 gene (neurobeachin-like 1) is predicted to have protein kinase binding activity and is suggested to be involved in protein localization. The protein is predominantly expressed in the brain, kidney, prostate, and testis, with weaker expression observed in the ovary, small intestine, colon, and peripheral blood leukocytes. Additionally, NBEAL1 may have an association with various tumors, such as serous adenocarcinoma of the ovary and metastatic mammary gland carcinoma of the breast.

### Associated Genes
While the gene summary provided does not specify other associated genes, it is important to note that NBEAL1 may be implicated in complex interactions with the following types of genes:

1. **Cancer-related genes:** Tumor suppressor genes and oncogenes in pathways contributing to the development and progression of tumors where NBEAL1 expression is noted.
2. **Genes involved in cell signaling pathways:** Genes that encode proteins involved in pathways influencing cell localization and protein interactions.

### Aging and Age-related Diseases
Current knowledge about NBEAL1's direct role in aging or age-related diseases is limited. However, its expression in various tissues and potential involvement in tumor processes might suggest that dysregulation of this gene could contribute to cancer risk as individuals age. Additionally, any slow decline or change in expression related to cell signaling may indirectly influence age-associated conditions, though specific studies directly linking NBEAL1 with aging or age-related diseases are not robustly established.

### Drug Interactions
At present, there are no specific drugs or drug classes conclusively known to interact directly with the NBEAL1 gene or its protein product. However, drugs targeting pathways related to protein localization or kinases may affect its function indirectly through their effects on cellular processes in tissues where NBEAL1 is highly expressed.

### Biological Pathways and Processes
NBEAL1 is thought to be involved in the following biological pathways and processes:

1. **Protein localization:** Influencing the spatial distribution of proteins within the cell.
2. **Cell signaling pathways:** Although specific pathways are not well-characterized, NBEAL1's kinase binding potential suggests roles in signal transduction.
3. **Cell proliferation and tumorigenesis:** The correlation of NBEAL1 with various tumors indicates a potential role in cancer-related pathways.

### Summary
NBEAL1 is a gene with a connection to protein localization, tumor biology, and expression variations across different tissues, particularly in those involved in reproductive and neurological functions. Although specific associations with aging and drug interactions remain to be explored further, its roles in fundamental cellular processes suggest that it may be a topic of interest in both cancer research and the study of cellular aging mechanisms. Further investigation is needed to elucidate its precise functional roles and clinical implications.