### FLNC-AS1 Gene Overview

**Gene Symbol**: FLNC-AS1  
**Full Name**: FLNC antisense RNA 1

FLNC-AS1 is a long non-coding RNA (lncRNA) gene that is positioned in an antisense orientation to the FLNC gene, which encodes the protein filamin C, part of the filamin family involved in actin cytoskeleton organization, cellular architecture, and mechanical stability of cells. Non-coding RNAs, particularly lncRNAs, are increasingly recognized for their regulatory roles in gene expression, cellular processes, and potentially in disease mechanisms.

### 1. Associated Genes

While comprehensive association studies specific to FLNC-AS1 are limited, it is known to be associated with the following gene, primarily due to its positional and functional relationship:

- **FLNC**: The corresponding protein-coding gene that FLNC-AS1 regulates. FLNC is involved in muscle structure and function, and mutations in FLNC are linked to various cardiomyopathies and muscular dystrophies.

Indirectly, FLNC-AS1 may be associated with other genes participating in cytoskeleton dynamics or related cellular pathways, but specific data on these associations may need targeted research or databases for confirmation.

### 2. Details Related to Aging and Age-Related Diseases

Research on lncRNAs is growing concerning their roles in aging and age-related conditions. Though specific data for FLNC-AS1 in the context of aging is sparse, its position as an antisense RNA to a gene involved in cytoskeletal integrity suggests potential implications. Alterations in the cytoskeletal framework have been linked to cellular senescence, muscle degeneration, and age-related diseases. Moreover, lncRNAs like FLNC-AS1 might play roles in:

- **Senescence Regulation**: Affects cellular aging processes.
- **Skeletal Muscle Degeneration**: Given the association with FLNC, it may contribute to muscle-related pathologies commonly seen with aging, like sarcopenia.

Further investigation is required to delineate detailed roles in these contexts.

### 3. Drug Interactions

Currently, there is limited information on specific drugs or drug classes directly interacting with FLNC-AS1. However, since FLNC-AS1 is involved in the regulation of FLNC, any therapies targeting filamin C or affecting cytoskeletal dynamics (for example, in muscle-related diseases) might indirectly involve FLNC-AS1:

- **Potential Drug Classes**: Antisense oligonucleotides targeting lncRNAs, myofilament-enhancing compounds used in muscle disorders, or drugs impacting cytoskeletal organization (e.g., certain chemotherapeutics) might affect the regulatory network involving FLNC-AS1.

### 4. Pathways and Biological Processes

FLNC-AS1 participates in several biological processes, primarily through its association with FLNC and related cellular functions:

- **Cytoskeletal organization**: Involved in maintaining the integrity and structure of cells.
- **Cell adhesion**: This is crucial for tissue integrity and function.
- **Regulation of gene expression**: Through interactions with transcription factors or influencing mRNA stability.
- **Muscle structure and function**: Implicated in cardiac and skeletal muscle biology.

### Conclusion

FLNC-AS1 plays a significant role in regulating aspects of gene expression associated with muscle integrity and cytoskeletal functions. While its direct associations with aging and drug interactions require further research, its regulatory mechanism and involvement in pathways relevant to cellular architecture highlight its potential importance in human health and disease. The study of lncRNAs like FLNC-AS1 continues to evolve, offering insights into their multifaceted roles in biology and pathology.