### RBM39 Gene Overview

**Gene Symbol:** RBM39  
**Chromosomal Location:** Chromosome 13  
**Gene Type:** Protein-coding  

The RBM39 gene encodes an RNA-binding protein that is involved in pre-mRNA splicing as well as transcriptional regulation. This gene is notable for its interactions with spliceosomal components and its role in enhancing exon inclusion during alternative splicing. Additionally, RBM39 interacts with nuclear receptors and enhances their transcriptional activities.

### 1. Associated Genes

While the summaries mention its relation to steroid nuclear receptors like ESR1/ERα and ESR2/ERβ, and JUN/AP-1, RBM39 may also interact with several other genes and proteins involved in splicing and gene regulation, such as:

- **U2AF2** (U2 small nuclear RNA auxiliary factor 2) - A component of the U2AF complex that recognizes the 3' splice site in pre-mRNA.
- **SF3B1** (Splicing factor 3B subunit 1) - Involves in the splicing machinery.
- **SNRNP70** - A core component of the spliceosome.

### 2. Aging and Age-Related Diseases

The RBM39 gene has not been extensively linked to aging or specific age-related diseases in the literature up to October 2023. However, splicing factors, in general, are known to be important in maintaining cellular homeostasis and gene regulation as organisms age. Dysregulation of alternative splicing has been linked to age-associated diseases like cancer and neurodegenerative disorders. 

Additionally, alterations in the expression of splicing factors may result in age-related declines in cellular function, potentially implicating RBM39 in these broader phenomena.

### 3. Drug Interactions

There is limited specific information on drug interactions directly associated with RBM39. However, the gene's role in regulation of steroid hormone receptors may suggest potential interactions with:

- **Selective Estrogen Receptor Modulators (SERMs)** - These would include drugs used in hormone replacement therapy and treatments for hormone-dependent cancers.
- **Glucocorticoids** - Compounds that bind to glucocorticoid receptors, which may engage RBM39 in regulation processes.

Research into the specific regulatory roles and interactions of RBM39 could yield more precise details on how existing treatments involving these receptor systems might affect or involve this gene.

### 4. Pathways and Biological Processes

RBM39 is involved in numerous biological processes, including but not limited to:

- **Pre-mRNA Splicing** - It acts as a splicing factor, promoting exon inclusion during the splicing of precursor mRNA.
- **Transcription Regulation** - Functions as a transcriptional coactivator for nuclear receptors (including steroid receptors) and transcription factors like JUN.
- **Response to Hormones** - Particularly in the context of steroid hormones due to its interaction with ESR1/ERα and ESR2/ERβ.
- **Cell Proliferation and Differentiation** - It may also play a role in processes related to cell cycle and response to signaling pathways linked to growth factors and hormones.

### Conclusion

The RBM39 gene emerges as an important player in mRNA splicing and transcriptional regulation, notably in the context of steroid hormone signaling. Although not directly implicated in aging-related diseases, its broader role in splicing and regulation positions it as a gene of interest for further studies, particularly in the context of cellular aging and homeostasis.