### RNU6-450P Gene Overview

**Gene Symbol:** RNU6-450P  
**Gene Type:** Non-coding RNA (specifically, a small nucleolar RNA - snoRNA)

RNU6-450P is a member of the U6 small nuclear RNA family, which plays a critical role in the splicing process of pre-mRNA by forming a part of the spliceosome and is involved in the modification of other RNA molecules.

#### 1. Associated Genes

RNU6-450P has been linked to various other genes, particularly those that also encode small nucleolar RNAs or other components of the spliceosome machinery. Some of the associated genes include:

- RNU6-1 (U6 small nuclear RNA)
- RNU6-2 (U6 small nuclear RNA)
- Other snoRNA genes within the U6 and U3 families.

Numerous non-coding RNA genes may also exhibit co-expression or regulatory relationships with RNU6-450P; however, comprehensive lists would require specific genetic interaction databases or co-expression studies for exhaustive details.

#### 2. Aging and Age-related Diseases

While specific studies on RNU6-450P concerning aging or age-related diseases are limited, small nucleolar RNAs, in general, have been implicated in various regulatory processes that could influence cellular aging. For instance, alterations in RNA splicing and modifications have been observed in age-related degeneration and diseases like Alzheimer's disease or cancer. However, more research is needed to pinpoint direct associations of RNU6-450P with these conditions.

#### 3. Drug Interactions

Currently, there is no specific drug or drug class directly known to interact with the RNU6-450P gene. However, given the gene's involvement in RNA splicing, general drugs that modulate splicing, such as certain antisense oligonucleotides or small molecules aimed at spliceosome complexes, could indirectly impact the function of RNU6-450P. Again, detailed interactions would benefit from further investigation and specific pharmacogenomic studies.

#### 4. Pathways and Biological Processes

RNU6-450P is primarily involved in the following biological processes:

- **RNA Splicing**: Engaged in the splicing of pre-mRNA into mature mRNA, facilitating the removal of intronic regions.
- **Modification of rRNA and snRNA**: Contributes to post-transcriptional modification of rRNAs (ribosomal RNA) and snRNAs (small nuclear RNAs).
- **Gene Regulation**: Involved indirectly in the regulation of gene expression through the modulation of mRNA splicing dynamics.

This gene may also have roles in nuclear processes associated with transcription regulation and RNA metabolism.

### Summary

RNU6-450P is an essential non-coding RNA primarily involved in pre-mRNA splicing and RNA modification processes. While direct associations with aging or specific therapeutics remain to be clarified through further research, its participation in RNA splicing and regulation suggests a foundational role in cellular processes with potential implications for age-related research.