### PSMA6P3 Gene Overview

**Gene Name:** PSMA6P3  
**Alternative Names:** None explicitly mentioned in the provided summaries, but it is worth noting that this gene is a pseudogene.

**Location:** The PSMA6P3 gene is located on chromosome 14 in humans and is associated with the PSMA (Prospective Membrane Antigen) family of genes, which are involved primarily in the regulation of proteasome activity and protein degradation.

### Association with Other Genes

PSMA6P3 is a pseudogene derived from the PSMA6 gene, which encodes a subunit of the proteasome, a protein complex that plays a crucial role in degrading ubiquitinated proteins. While there are no direct associations mentioned with other specific genes, PSMA6P3 could potentially influence or be influenced by genes involved in proteasome function and protein homeostasis, such as those coding for other proteasome subunits (e.g., PSMA1, PSMA2, PSMA3, etc.).

### Details Related to Aging and Age-Related Diseases

Current knowledge indicates that proteasomal activity declines with age, which may lead to the accumulation of damaged proteins and cellular dysfunction. Since PSMA6 is involved in proteasome activity, there may be an indirect association of PSMA6P3 with age-related diseases, such as neurodegenerative disorders (Alzheimer's disease, Parkinson's disease) that are linked to protein aggregation. However, specific research linking PSMA6P3 directly to aging or age-related diseases remains limited, as many pseudogenes are not typically considered as active genetic elements.

### Drug and Drug Classes Interaction

No specific drugs or drug classes are currently documented to interact with the PSMA6P3 gene. As a pseudogene, it may not be directly involved in therapeutic interactions. However, drugs affecting proteasome activity (e.g., bortezomib, carfilzomib) could indirectly relate to the biological processes where the parent gene, PSMA6, is involved.

### Pathways and Biological Processes

Given the relationship with the PSMA6 gene, which is part of the 20S core of the proteasome, PSMA6P3 may be implicated in various biological processes related to:

- **Protein Degradation:** Involved in cellular protein turnover and maintaining protein homeostasis.
- **Ubiquitin-Proteasome Pathway:** Plays a significant role in the regulation and breakdown of ubiquitinated proteins.
- **Cell Cycle Regulation:** Protein degradation is critical in cell cycle progression, and disruptions in this pathway can lead to uncontrolled cell division or cancer.
- **Response to Cellular Stress:** The degradation of damaged or misfolded proteins is crucial for cellular response during stress conditions.

### Summary

PSMA6P3 is a pseudogene associated with the PSMA family, primarily known for encoding parts of the proteasome machinery. Its links to aging and potential drug interactions remain largely unexplored and require further investigation to fully understand its role in biological processes and disease contexts.