### CEP192 Gene Overview

**Gene Symbol**: CEP192  
**Location**: The CEP192 gene is located on chromosome 8.

### 1. Associated Genes
While the provided summaries mention AURKA (Aurora Kinase A) and PLK1 (Polo-like kinase 1), CEP192 is also known to interact with several other genes and proteins, which include:

- **CDK2**: Cyclin-dependent kinase 2, involved in cell cycle regulation.
- **TPX2**: A microtubule-associated protein involved in spindle assembly.
- **CDC20**: Activates the anaphase-promoting complex during mitosis.

### 2. Aging and Age-Related Diseases
CEP192 has been shown to play a critical role in maintaining genomic stability, which may decline with age. Alterations or dysregulation of CEP192 may contribute to:

- **Age-related diseases**: Such as cancer, where improper mitosis and centrosome function can lead to chromosomal instability.
- **Neurodegenerative diseases**: Abnormalities in centrosome function have been associated with neurodegenerative disorders, suggesting CEP192 may play a role in these conditions.

### 3. Drug Interactions
Currently, specific drug interactions with CEP192 are not well characterized; however, as it is involved in cell division and centrosome function, it may be indirectly influenced by:

- **Antimitotic drugs**: Such as taxanes (e.g., paclitaxel), which disrupt microtubule dynamics, potentially impacting pathways in which CEP192 is involved.
- **Aurora kinase inhibitors**: Since CEP192 is a regulator of AURKA, drugs that inhibit this kinase could hypothetically interact with the functions modulated by CEP192.

### 4. Pathways and Biological Processes
CEP192 is associated with various cellular pathways and biological processes, including:

- **Centrosome cycle and function**: CEP192 is crucial for centrosome maturation, PCM recruitment, and centriole duplication.
- **Microtubule organization**: Involved in mitotic spindle assembly and organization of the microtubule cytoskeleton.
- **Cell cycle regulation**: Plays a role in the progression through different phases of the cell cycle, particularly in the transition from G2 to mitosis.
- **Regulation of PLK1 and AURKA**: Acts as an activating scaffold for these kinases, which are critical for initiating various events during mitosis.

### Summary
The CEP192 gene plays a vital role in the proper functioning of centrosomes and the overall regulation of the cell cycle. Its involvement in several processes related to cell division and organization means that it occupies a significant position in studies related to cancer biology and aging, with implications for future therapeutic targets related to these areas. Further research may help elucidate the full scope of its interactions and the potential as a drug target.