### PSMA3-AS1 Gene Overview

**Gene Symbol:** PSMA3-AS1  
**Gene Type:** Long non-coding RNA (lncRNA)  
**Chromosomal Location:** Human chromosome 14

**Function:** The PSMA3-AS1 gene is classified as an antisense long non-coding RNA associated with the PSMA3 gene, which encodes a subunit of the proteasome. The proteasome is essential for protein degradation and maintaining cellular protein homeostasis. While the exact functional role of PSMA3-AS1 is not fully understood, lncRNAs are known to play critical regulatory roles in gene expression and chromatin remodeling.

### Associated Genes

While the summaries did not specify associated genes, lncRNAs frequently interact with several other genes and proteins depending on the biological context. PSMA3-AS1 could be associated with:
- PSMA3: The gene whose expression it regulates.
- Other genes involved in proteasome-related pathways, such as PSMA1, PSMA2, and PSMA4, based on its involvement in the protein degradation pathway.

### Association with Aging or Age-Related Diseases

Research indicates that certain lncRNAs, including PSMA3-AS1, may be involved in the regulation of cellular processes associated with aging, such as inflammation, cellular senescence, and stress responses. However, specific studies clarifying the role of PSMA3-AS1 in aging or age-related diseases would be necessary for more precise information. There is currently limited direct evidence that links PSMA3-AS1 specifically to age-related diseases; however, its association with proteasome activity suggests potential implications in diseases characterized by protein misfolding, such as Alzheimer’s disease.

### Drug Interactions

As of the latest knowledge, there are no specific drugs or drug classes directly known to interact with PSMA3-AS1. However, since it is associated with the regulation of the proteasome pathway, drugs that target proteasomes (such as proteasome inhibitors used in cancer therapy, e.g., bortezomib) may indirectly influence the expression or function of PSMA3-AS1.

### Pathways and Biological Processes

PSMA3-AS1 is likely involved in various biological processes, including:
- **Protein Degradation:** The gene is associated with the proteasome pathway, essential for the degradation of ubiquitinated proteins.
- **Gene Regulation:** As a lncRNA, PSMA3-AS1 may regulate the transcription of nearby genes, potentially influencing protein expression patterns.
- **Cell Cycle Regulation:** Given its relationship with proteasome function, PSMA3-AS1 may play a role in regulating the cell cycle and cellular response to stress.
  
More empirical studies would help clarify the specific pathways and biological processes in which PSMA3-AS1 is implicated.

### Summary

In summary, PSMA3-AS1 is an antisense lncRNA associated with the PSMA3 gene, playing a potential role in protein degradation and gene regulation. Its implications in aging and age-related diseases require further study, and while direct drug interactions are unclear, there are relevant connections to proteasome-targeting therapies. The pathways linked to this gene primarily relate to protein metabolism and cellular regulatory mechanisms.