### INO80D Gene Overview

**Gene Symbol:** INO80D  
**Location:** Predicted to be located in the nucleoplasm and active in the nucleus.  

#### Summary
The INO80D gene encodes a putative regulatory component of the INO80 chromatin remodeling complex, which plays important roles in transcriptional regulation, DNA replication, and likely DNA repair. This gene is particularly implicated in processes involving DNA recombination and repair mechanisms.

### 1. Associated Genes
INO80D has been reported in literature to interact or be associated with several other genes, specifically those involved in chromatin remodeling and DNA repair processes. Some of the notable associated genes include:

- **INO80**: The core component of the INO80 complex.
- **ARID1A/B**: Members of the SWI/SNF chromatin remodeling complexes, which may collaborate with INO80-related functions.
- **ATM**: Ataxia telangiectasia mutated, a key player in DNA damage response pathways.
- **BRCA1/BRCA2**: Genes associated with DNA repair mechanisms; may interact indirectly through repair pathways.
  
### 2. Aging and Age-related Diseases
While specific studies directly linking INO80D to aging or age-related diseases may be limited, general insights into chromatin remodeling complexes have indicated their involvement in cellular senescence and genomic stability. Dysregulation in DNA repair mechanisms (which INO80D is predicted to be involved with) is a hallmark of aging and contributes to age-related diseases, including cancer. A better understanding of how INO80D functions could contribute to insights into longevity and age-related pathologies.

### 3. Drug Interactions
As of the latest data available, specific drug interactions directly involving INO80D are not extensively documented. However, given its role in DNA repair, compounds that target DNA repair pathways or chromatin remodeling could potentially impact the function of INO80D, although direct interactions with specific drugs or classes remain an area for further research. Classes that could impact pathways involving INO80D include:

- **DNA Repair Inhibitors**: Such as PARP inhibitors, which may affect pathways involving INO80D.
- **Histone Deacetylase Inhibitors (HDAC inhibitors)**: These could affect chromatin remodelers, potentially influencing how INO80D operates.

### 4. Pathways and Biological Processes
The INO80D gene is implicated in several critical biological processes and pathways, such as:

- **Chromatin Remodeling**: The INO80D component plays a role in altering chromatin structure to enable or restrict access to DNA for transcription and replication.
- **DNA Repair Mechanisms**: Participation in homologous recombination and non-homologous end joining pathways.
- **Transcription Regulation**: It is involved in modifying the chromatin landscape to facilitate or inhibit access to transcription factors and polymerases.
- **Cell Cycle Regulation**: Implicated in processes that ensure proper DNA replication and repair before cell division.

### Conclusion
The INO80D gene plays a crucial role in the chromatin remodeling complex involved in DNA repair and transcription regulation. Its associations with other genes underline its significance in genomic stability, which is critical for the prevention of age-related diseases and cancer. Future research may provide a clearer understanding of its pharmaceutical interactions and implications for aging processes.