### SHISA3 Gene Overview

**Gene Symbol:** SHISA3  
**Location:** Human Chromosome 8p12

The SHISA3 gene encodes a single-transmembrane protein that is part of a family of nine similar proteins. This family predominantly functions as adaptors that modulate the signaling pathways of WNT and FGF (Fibroblast Growth Factor) by preventing the maturation and transportation of their respective receptors to the cell surface. The SHISA3 protein is characterized by its cysteine-rich N-terminus, a single transmembrane domain, and a proline-rich low complexity C-terminus. It has been identified as a tumor suppressor that facilitates beta-catenin degradation, thereby influencing WNT signaling and cell proliferation.

### 1. Associated Genes

While specific gene associations may not have been detailed in the provided summaries, SHISA3 is known to interact and affect the expression or activity of various genes involved in the WNT and FGF signaling pathways. Some noteworthy genes that may have interactions with SHISA3 include:

- **CTNNB1 (Beta-catenin):** Directly related to WNT signaling and stability.
- **FGFR1/2 (Fibroblast Growth Factor Receptors):** Direct modulators of FGF signaling.
- **AXIN:** Involved in WNT pathway regulation and beta-catenin degradation.

### 2. Aging and Age-Related Diseases

While there's limited research explicitly connecting SHISA3 to aging or specific age-related diseases, the modulation of WNT and FGF signaling pathways is essential for many physiological processes that can influence aging and disease states. Abnormalities in these pathways have been linked to:

- Cancer: Given its role as a tumor suppressor, disturbances in SHISA3 function could contribute to tumorigenesis.
- Developmental Disorders: Disruptions during embryogenesis may lead to conditions related to age, as well as developmental abnormalities.
- Metabolic Disorders: WNT signaling has also been implicated in metabolic processes, which are crucial as one ages.

Research regarding the direct involvement of SHISA3 in aging or age-related diseases is still evolving.

### 3. Drug Interactions

Currently, specific drugs or drug classes that directly target or interact with SHISA3 have not been widely documented. Given its roles in tumor suppression and signaling pathways, researchers may consider exploring:

- **WNT Pathway Modulators:** These include both agonists and antagonists that alter beta-catenin activity.
- **FGF Pathway Modulators:** Drugs targeting FGFRs, as alterations in their signaling can be related to cancer therapies.

Further studies are likely needed to elucidate any precise pharmacological interactions.

### 4. Pathways and Biological Processes

SHISA3 is involved in several critical pathways and biological processes, including:

- **WNT Signaling Pathway:** Essential for various developmental processes and cell differentiation.
- **FGF Signaling Pathway:** Plays a critical role in cell growth, tissue repair, and embryonic development.
- **Regulation of beta-catenin Levels:** Involved in the degradation pathway affecting cell adhesion and transcription regulation.
- **Cell Cycle Regulation:** Inhibits pathways promoting uncontrolled cell proliferation, acting as a tumor suppressor.

### Conclusion

The SHISA3 gene plays a multifaceted role primarily in embryonic development and tumor suppression through its modulation of critical signaling pathways. Ongoing research may provide further insights into its potential implications in aging, age-related diseases, and therapeutic interventions targeting associated pathways.