### IGFLR1 Gene Overview

**Gene Symbol:** IGFLR1

**Location:** Plasma membrane

**Function:** The IGFLR1 gene encodes a probable cell membrane receptor for the insulin-like growth factor (IGF) family of proteins, particularly binding with high affinity to IGFL1 and IGFL3, and potentially binding to IGFL2 as well. 

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### 1. Associated Genes
While IGFLR1 is primarily highlighted for its interactions with the IGF-like family proteins (particularly IGFL1, IGFL2, and IGFL3), it may also have associations with the following genes due to the signaling pathways and biological processes in which it is involved:

- **IGF1:** The receptor for the major insulin-like growth factor, which intersects with IGFLR1 signaling.
- **IGF1R:** The insulin-like growth factor 1 receptor, which is involved in growth and developmental processes and is related due to the functional similarities within the IGF family.
- **IGFBP family (e.g., IGFBP1, IGFBP3):** Insulin-like growth factor-binding proteins that modulate the availability and activity of IGFs.

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### 2. Aging and Age-Related Diseases
While specific research directly linking IGFLR1 to aging or age-related diseases is limited, insulin-like growth factors are integral to several physiological processes that can affect aging. Some notable points include:

- **Growth and Development:** IGFLR1 may play a role in growth factor signaling, which is crucial for developmental processes. Dysregulation of growth factor signaling is often implicated in aging.
- **Cancer:** Altered signaling pathways involving IGFs and their receptors are known to contribute to tumorigenesis and can affect cancer progression, which is prevalent in aging populations.
- **Metabolic Syndrome:** IGF signaling may also influence metabolic processes that are disrupted with aging, linking to conditions such as diabetes and obesity.

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### 3. Drug Interactions
As of the most current research, there are no specific drugs or drug classes exclusively known to interact with IGFLR1. However, there are several relevant classes of drugs that target IGF signaling in general, which may indirectly affect IGFLR1's activity:

- **IGF-1 Receptor Inhibitors:** Drugs designed to inhibit IGF signaling, relevant for treating cancers where IGF pathways are overactive.
- **Growth Hormone Secretagogues:** These may indirectly influence IGFLR1 activity by altering systemic IGF levels.

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### 4. Pathways and Biological Processes
IGFLR1 is involved in a number of important biological processes and signaling pathways, including:

- **IGF Signaling Pathway:** As a receptor related to IGF-like proteins, IGFLR1 is part of the broader insulin/IGF signaling pathways which regulate cell growth, proliferation, survival, and differentiation.
- **Cell Growth and Division:** By binding to IGF-like proteins, IGFLR1 may mediate key aspects of cellular responses essential for growth and metabolism.
- **Developmental Processes:** Roles in both embryonic development and post-natal growth are likely given its function as a receptor responding to growth factors.

Overall, IGFLR1 serves a significant role in the signaling network governing growth and metabolism, with implications in aging and diseases related to growth factor dysregulation. Further discoveries are likely to clarify its specific role in pathology and potential therapeutic targets.