### CASC9 Gene Overview

**Gene Symbol**: CASC9  
**Full Name**: Cancer susceptibility 9  
**Chromosomal Location**: The CASC9 gene is located on chromosome 8q24, an area often associated with various cancers.

#### Additional Genes Associated with CASC9
While the NCBI and UniProt summaries may not list them, CASC9 has been implicated in interactions and associations with several other genes, especially those involved in oncogenesis. Some notable associations include:
- **MYC**: The CASC9 region is closely linked to the MYC oncogene, which is frequently upregulated in cancers.
- **CCND1**: Research has shown associations between CASC9 and cyclin D1, which plays a crucial role in cell cycle regulation.
- **AR**: The androgen receptor, especially in the context of prostate cancer.
- **PTEN**: An important tumor suppressor gene implicated in various cancers.

#### Aging and Age-related Diseases
- **Cancer Risk**: Variants in the CASC9 region have been associated with an increased risk of various types of cancer, including prostate, breast, and colorectal cancers. This implicates CASC9 in age-related carcinogenesis, as cancer risk typically increases with age.
- **Cellular Senescence**: While direct associations with cellular aging have not been as extensively studied, given its role in cancer and the altered regulation of genes involved in the aging process, CASC9 may influence pathways that govern cellular senescence and longevity.

#### Known Drug Interactions
Currently, there are no specific drugs or drug classes that directly target CASC9. However, given its associations with cancer, many anticancer drugs (like chemotherapeutics) and targeted therapies (e.g., drugs targeting the MYC oncogene-related pathways) could indirectly be influenced by the expression or mutations in the CASC9 gene.

#### Pathways and Biological Processes
CASC9 is known to be involved in several critical pathways and biological processes, including:
- **Gene Regulation**: As a long non-coding RNA (lncRNA), CASC9 may regulate gene expression at various levels, influencing tumorigenesis.
- **Wnt Signaling Pathway**: There is evidence of involvement in the Wnt signaling pathway, which is crucial in cell proliferation, differentiation, and cancer progression.
- **Transcription Regulation**: Helps in regulating transcription of nearby genes, particularly those involved in oncogenic processes.

Overall, while the CASC9 gene is primarily recognized for its role in cancer susceptibility, its potential link to aging and age-related diseases continues to garner research interest, underscoring the complex interplay between genetics, aging, and disease.