### FBXO36 Gene Overview
**Gene Symbol:** FBXO36  
**Function:** The FBXO36 gene encodes a protein that serves as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. This complex is primarily involved in the ubiquitination of target proteins, marking them for degradation via the proteasome and playing crucial roles in regulating various cellular processes.

### 1. Associated Genes
While specific associated genes may not be universally defined, FBXO36 is part of the larger SKP1/CUL1/F-box (SCF) E3 ligase complex and may interact with numerous substrates and partner proteins. Some associated members of the SCF complex include:
- **SKP1 (S-phase kinase-associated protein 1)**: A critical component of the SCF E3 ligase complex.
- **CUL1 (Cullin 1)**: Functions as the scaffold within the SCF complex.
- **FBXW8, FBXO7, FBXL3**: Other F-box proteins that may similarly regulate protein degradation.

### 2. Aging and Age-related Diseases
Several studies suggest that FBXO36 may be implicated in cellular processes that are relevant to aging, particularly in the context of protein homeostasis and degradation. Accumulation of damaged or misfolded proteins is a hallmark of aging, and E3 ubiquitin ligases, including FBXO36, play critical roles in the protein quality control pathways. While direct associations with age-related diseases are still being elucidated, the dysregulation of ubiquitin-proteasome pathways has been linked to several conditions, including:
- Neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease)
- Cancer (through the aberrant regulation of oncogenes and tumor suppressor genes) 
  
Some research may reveal potential roles of FBXO36 in senescence or cancer mechanisms, but additional studies are required for definitive conclusions.

### 3. Drug Interactions
Currently, there are no specific drugs directly targeting FBXO36 known in the literature as of October 2023. However, drugs that influence the ubiquitin-proteasome system (UPS) can indirectly influence the substrates of FBXO36. Notably:
- **Proteasome inhibitors:** Used primarily in cancer therapy (e.g., Bortezomib) may alter the expression and activity of E3 ligases including FBXO36 due to global changes in protein degradation pathways.
- **Targeting specific pathways:** Future drug development targeting the SCF complex could indirectly affect FBXO36 activity.

### 4. Pathways and Biological Processes
FBXO36 is involved in several important biological processes and pathways, including:
- **Ubiquitin-mediated proteolysis:** This process is fundamental for regulating protein turnover, cell cycle progression, DNA repair, and responding to cellular stress.
- **Signal transduction pathways:** Involvement in pathways where protein stabilization and degradation are critical for maintaining cellular responses to stimuli (e.g., growth factors, stress signals).
- **Cell cycle regulation:** Proteins involved in the cell cycle are often substrates for ubiquitination by SCF complexes, implicating FBXO36 in cell proliferation processes.
  
FBXO36's role as a substrate-recognition component suggests it may play a selective role in targeting specific substrates for degradation, which is crucial for maintaining cellular function and integrity.

### Conclusion
The FBXO36 gene is a key component of the ubiquitin-proteasome system, contributing to the regulation of various cellular processes and potentially having implications in aging and disease mechanisms. However, further research is warranted to fully elucidate its roles and interactions.