### FKBP15 Gene Overview

The FKBP15 gene encodes a protein that is part of the FK506-binding protein family, which is known for peptidyl-prolyl cis-trans isomerase (PPIase) activity. This gene may play a critical role in cytoskeletal organization, particularly in neuronal growth cones, and is implicated in processes such as endocytosis and transport of early endosomes. Below are the additional details regarding FKBP15.

#### 1. Associated Genes
While FKBP15’s direct interactions may not be comprehensively cataloged, genes that are generally associated with cytoskeletal organization, endocytic pathways, or neuronal function could potentially be associated with FKBP15. Notable examples could include:
- **ACTB (Beta-actin)**: Involved in maintaining cellular structure and motility.
- **MAPT (Microtubule-associated protein tau)**: Important for microtubule stability in neurons.
- **AP2A1 (AP2 complex subunit alpha)**: Involved in clathrin-mediated endocytosis.
- **DYN1 (Dynamin 1)**: Important for vesicle scission during endocytosis.

#### 2. Aging and Age-Related Diseases
Research directly linking FKBP15 to aging or age-related diseases is still developing. However, its role in cytoskeletal organization and endocytosis suggests it could have implications in:
- **Neurodegenerative diseases**: Alterations in neuronal growth and endocytosis processes have been implicated in conditions such as Alzheimer's Disease and Parkinson's Disease.
- **Cellular senescence**: Dysregulation of cytoskeletal components may contribute to aging cellular phenotypes.

### 3. Drug Interactions
While specific drugs directly targeting FKBP15 are not extensively documented, members of the FKBP family are known to interact with various immunosuppressive and anti-inflammatory drugs. Drugs of interest include:
- **FK506 (Tacrolimus)**: Known to bind FKBP proteins including FKBP15, although FKBP15's role in immunosuppression is lesser-known compared to FKBP12.
- **Rapamycin and its analogs**: While primarily targeting mTOR, these can indirectly influence FKBP family proteins involved in signaling pathways.

#### 4. Pathways and Biological Processes
FKBP15 is involved in several biological pathways and processes:
- **Endocytosis**: Crucial for cellular uptake of material through vesicle transport, and FKBP15's role suggests it assists in proper endosome function.
- **Cytoskeletal organization**: FKBP15 may influence the structural arrangement of actin and microtubule filaments, which is vital for neuronal growth and synaptic function.
- **Cell signaling pathways**: Given its function in protein isomerization and interaction with cytoskeletal proteins, FKBP15 may play a role in cellular signaling related to growth and differentiation.

### Conclusion
The FKBP15 gene is an important player in maintaining cellular architecture, especially in neurons, and likely participates in crucial processes that can be implicated in neurodegenerative diseases and cellular aging. Understanding FKBP15's interactions and involvement in biological pathways is essential for elucidating its role in health and disease. Further research may provide deeper insights into its clinical implications and therapeutic potential.