### OR52E2 Gene Overview

**Gene Symbol:** OR52E2  
**Location:** Human chromosome 11 (11q12)  
**Function:** The OR52E2 gene encodes a member of the olfactory receptor family, which plays a critical role in the sensory perception of smell by binding odorant molecules and initiating a neuronal response through G-protein-coupled signaling pathways. Olfactory receptors are characterized by their seven-transmembrane domain structure and contribute to the recognition and transduction of odorant signals.

### 1. Associated Genes
While no specific genes are universally recognized as being directly associated with OR52E2 in the public databases, members of the olfactory receptor gene family are often co-localized or clustered in certain regions of the genome. Other related olfactory receptors may include genes such as:
- OR52E1
- OR52E3
- OR52E4
These receptors typically share functions and structural characteristics with OR52E2.

### 2. Aging and Age-Related Diseases
Research on specific olfactory receptor genes and their associations with aging is still emerging. The role of olfactory receptors, including OR52E2, in aging may relate to:
- **Olfactory Dysfunction:** Studies have shown that olfactory function declines with age and may be an early indicator of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. While direct associations with OR52E2 haven’t been established, its functional decline could contribute to age-related olfactory impairments.
- **Neurological Impacts:** Age-related changes in GPCR signaling pathways may affect olfactory function and neuroplasticity, potentially implicating genes involved in sensory perception.

### 3. Drug Interactions
There are currently no known specific drugs or drug classes that are publicly documented to interact with OR52E2. Mainly, olfactory receptors can contribute to various signaling pathways and might influence the action of certain drugs indirectly through sensory perception. However, targeted pharmacology that includes olfactory receptors is still an area of research.

### 4. Pathways and Biological Processes
**Biological Processes:**
- **Olfactory Sensory Perception:** OR52E2 is primarily involved in the detection of odorant molecules and the sensory processing of smells. This process plays an essential role in behavior and interaction with the environment.
- **Signal Transduction:** As a G-protein-coupled receptor (GPCR), the protein's activation initiates intracellular signaling cascades leading to odor perception.

**Pathways:**
- **GPCR Signaling Pathway:** Olfactory receptors, including OR52E2, are part of the broader GPCR signaling cascade, which plays roles in various physiological responses.
- **Neurotransmitter Release:** Olfactory receptor activation can influence neurotransmitter pathways that govern sensory input processing.

### Summary
The OR52E2 gene contributes to the complex sensory system in humans by enabling odor recognition and perception through a GPCR-mediated mechanism. While it is a member of the extensive olfactory receptor family, particular associations with other genes, age-related conditions, drug interactions, and specific biological pathways may require further dedicated research efforts to elucidate fully.