### FERMT3 Gene Overview

**Gene Symbol**: FERMT3  
**Location**: Chromosome 11 (11q13.5)  
**Function**: The FERMT3 gene encodes the protein Kindlin-3, which is involved in cell adhesion and integrin activation, playing a critical role in processes such as hematopoiesis and immune response.

### 1. Associated Genes
While the provided summaries do not mention specific genes associated with FERMT3, research indicates that FERMT3 may interact with or be functionally related to the following genes:

- **ITGB1** (Integrin Beta 1)
- **ITGB2** (Integrin Beta 2)
- **ITGB3** (Integrin Beta 3)
- **G2A** (GPR132 or G-protein coupled receptor 132)
- **RAP1A** (Ras-Related Protein 1A)

These genes are involved in cell signaling pathways and integrin activation, directly contributing to the functions of FERMT3.

### 2. Aging and Age-related Diseases
As of the latest literature, there are limited direct associations of FERMT3 with aging or age-related diseases. However, given its role in cell adhesion and immune response, FERMT3 might have implications in:

- **Aging-related immune dysfunction**: The function of leukocytes and their ability to adhere to endothelial cells can be impaired with age, potentially linking FERMT3 to age-related immune responses.
- **Thrombotic diseases**: Conditions such as venous thromboembolism (which are more prevalent in older populations) could be influenced by FERMT3 function due to its involvement in hemostasis and thrombosis.

### 3. Drugs and Drug Classes
Currently, there are no specific drugs or drug classes universally recognized for direct interaction with FERMT3. However, drugs affecting integrin pathways or those involved in the modulation of immune responses may indirectly influence the activity of FERMT3. Some potential classifications include:

- **Integrin inhibitors**: These drugs may target the integrin signaling pathway, potentially affecting the activity of proteins like Kindlin-3.
- **Anticoagulants**: Given FERMT3’s role in hemostasis and thrombosis regulation, interactions may occur here but are complex and not directly stated.

### 4. Pathways and Biological Processes
FERMT3 is implicated in several pathways and biological processes, including:

- **Integrin signaling pathway**: Essential for cell adhesion and communication within the hematopoietic system.
- **Cell adhesion**: Key role in maintaining the integrity of the vascular endothelium and facilitating leukocyte migration.
- **Platelet activation**: Important in hemostatic processes where platelets must adhere to injuries and each other.
- **Regulation of hematopoietic stem cell functions**: Involvement in the cellular microenvironment and interactions required for proper blood cell formation.

### Summary
The FERMT3 gene is crucial for integrin-mediated cell adhesion and is significant in hemostatic processes, with implications in immune responses. It is associated with several integrin genes but lacks direct links to specific age-related diseases or drug interactions. Its roles in cellular pathways emphasize the importance of further research in understanding its potential implications in aging and related pathologies.