### FAM120A Gene Overview

**Gene Symbol:** FAM120A  
**Function:** The FAM120A gene encodes a protein that exhibits RNA binding activity and is implicated in oxidative stress-induced survival signaling. It may play a role in the regulation of SRC family protein kinases, functioning as a scaffolding protein. FAM120A is notable for its ability to bind to IGF2 (Insulin-like Growth Factor 2) RNA, thus promoting the production of the IGF2 protein, which has significant implications for growth and development.

### Associated Genes

FAM120A is associated with several other genes, particularly those involved in signaling pathways and oxidative stress responses. While specific gene associations can vary based on context, notable related genes include:

- **IGF2:** Direct target and interaction due to RNA binding.
- **SRC Family Kinases (e.g., SRC, YES1, FYN):** Involved in the signaling pathways that FAM120A is known to influence.
- **PIK3CA and PIK3R1:** As part of the downstream signaling where FAM120A may act to facilitate the activation of PI3-kinase.

### Aging and Age-Related Diseases

FAM120A is thought to have implications in aging and age-related diseases due to its role in oxidative stress and cellular survival signaling. While concrete studies specifically linking FAM120A to aging are limited, its involvement in pathways associated with:

- **Cellular stress response:** Increased oxidative stress and cellular senescence are common in aging.
- **Cancer:** Alterations in IGF pathways and SRC signaling have been implicated in various cancers, which tend to have a higher incidence in older populations.

The modulation of IGF2 by FAM120A could influence growth signaling that is often dysregulated in age-related diseases and pathologies.

### Drug Interactions

While there may not be drugs that directly target FAM120A, its role in key signaling pathways means that it could be indirectly implicated in the effects of certain drugs. For example:

- **Anticancer agents:** Drugs that affect SRC kinases or PI3-kinase (e.g., dasatinib, a SRC-family kinase inhibitor).
- **Agents targeting IGF signaling:** Since FAM120A promotes IGF2 production, modulators of the IGF pathway may also have indirect effects.

### Pathways and Biological Processes

FAM120A is involved in various pathways and biological processes, as follows:

- **Cell Survival Signaling:** A key component in pathways responding to oxidative stress, aiding in cell survival.
- **Angiogenesis and Metabolism:** Through its interaction with IGF signaling, FAM120A may influence metabolic processes and the development of new blood vessels.
- **Signal Transduction Pathways:** Involved in the activation of SRC family kinases and subsequent downstream signaling pathways, such as the PI3K/Akt pathway.
- **RNA Binding and Regulation:** Functions in post-transcriptional regulation through its RNA-binding capabilities, particularly impacting the expression of IGF2.

### Summary

FAM120A is a multifaceted gene with crucial roles in cellular signaling, particularly related to oxidative stress and IGF signaling. Its involvement in various biological processes makes it a gene of interest for further studies, especially regarding its implications for aging, cancer, and associated pharmacological interactions.