### CDH10 Gene Overview

**Gene Symbol:** CDH10  
**Chromosomal Location:** Human chromosome 5q14.1  
**Gene Type:** Protein-coding gene  

CDH10 encodes a type II classical cadherin, which is a member of the cadherin superfamily of proteins that mediate calcium-dependent cell-cell adhesion. These proteins play crucial roles in the structural and functional organization of tissues throughout development and in adulthood. CDH10 is characterized by its extracellular domain containing five cadherin motifs, which are key for its adhesive properties.

#### 1. Associated Genes
In addition to CDH10, it has been linked to various genes and pathways. Here are some notable associations:

- **CDH2 (N-Cadherin):** Related through function in cell adhesion and neural development.
- **CDH13 (H-Cadherin):** Shares structural properties and may have overlapping roles in neural tissues.
- **CTNNB1 (β-catenin):** Interacts with cadherins and plays a role in the adhesion junction formation.
- **DSC2 (Desmocollin 2):** Part of the desmosome structure and associated with cell adhesion.
- **PAX6:** Involved in neurodevelopmental processes, possibly interacting with cadherin-related pathways.
  
#### 2. Aging and Age-Related Diseases
Although direct associations of CDH10 with aging are not extensively characterized, aberrations in cadherin function and expression have been linked with various age-related diseases:

- **Neurodegeneration:** Altered cadherin expression, including CDH10, could affect synaptic integrity, potentially leading to age-related cognitive decline.
- **Cancer:** The implication of CDH10 mutations in lung squamous cell carcinoma and colorectal cancer may be influenced by age, as cancer risk typically increases with advancing age.
- **Cardiovascular Diseases:** Disruption in cell adhesion mechanisms, including cadherin-related pathways, could participate in the aging process related to cardiovascular health.

#### 3. Drug Interactions
While specific drugs targeting CDH10 are not well-documented, cadherin-related interactions might suggest broader drug classes that could be of interest, including:

- **Cancer therapeutics:** Given the association with tumorigenesis, pharmacological agents targeting cell adhesion or pathways involving cadherins may indirectly influence CDH10 function.
- **Neuroprotective agents:** Compounds aimed at enhancing synaptic adhesion and connectivity might relate to CDH10 due to its role in synaptic functions.
  
#### 4. Pathways and Biological Processes
CDH10 is involved in numerous biological processes and pathways, including but not limited to:

- **Cell Adhesion:** A primary function is mediating calcium-dependent cell-cell adhesion, vital for maintaining tissue architecture.
- **Neurodevelopment:** Implicated in neuronal differentiation, synapse formation, and axonal growth and guidance.
- **Wnt Signaling Pathway:** Involvement with β-catenin suggests that CDH10 may play a role in Wnt signaling, impacting development and possibly cancer biology.
- **Cellular Processes:** Participates in processes such as apoptosis regulation, tissue morphogenesis, and inflammation responses.

### Conclusion
The CDH10 gene is essential for neural development and cellular adhesion, with implications in various diseases, particularly cancer. Its interaction with other genes and cellular processes signifies its importance in both developmental biology and potential therapeutic targets in age-related conditions. Further research is necessary to elucidate these connections comprehensively.