### GPR156 Gene Summary

**Gene Symbol:** GPR156  
**Description:** GPR156 (G protein-coupled receptor 156) is classified as an orphan receptor, meaning its endogenous ligand has not yet been identified. It belongs to the family of G protein-coupled receptors (GPCRs), which are involved in various physiological processes by signaling through G proteins.

### 1. Associated Genes:
While the NCBI and UniProt summaries do not provide extensive associated genes, literature suggests GPR156 has potential interactions or associations with other receptor genes, particularly those within the GPCR family. Commonly studied related receptors include:

- **GPRC5A**
- **GPR3**
- **GPR63 (also known as GPRK2)**
- **GPR132 (also known as miR-155 host gene)**

These associations often arise from shared pathways or common roles in cell signaling and communication.

### 2. Aging or Age-Related Disease Associations:
Research into the precise role of GPR156 in aging or age-related diseases is limited. However, GPCRs are known to play roles in various physiological functions including metabolism, stress response, and inflammation, all of which are linked to aging. Some studies have suggested that dysregulation of GPCRs can be involved in age-related diseases such as:

- **Neurodegenerative diseases:** Alterations in GPCR signaling can affect neural health; while direct evidence for GPR156 is lacking, its role as an orphan receptor prompts exploration in neurobiology.
- **Cardiovascular diseases:** Impacts on heart health may be linked to GPCR activities, although specific mechanisms involving GPR156 require further investigation.

### 3. Drug Interactions:
As an orphan GPCR, direct pharmacological interactions with specific drugs or drug classes targeting GPR156 have not been established. However, other GPCRs often show interactions with classes such as:

- **Antihypertensives**
- **Antidepressants**
- **Antipsychotics**

Research is ongoing to discover if any endogenous ligands or synthetic compounds selectively target GPR156.

### 4. Biological Processes and Pathways:
GPR156, via its classification as a GPCR, is likely involved in several key biological processes including:

- **Cell signaling:** Involvement in signal transduction pathways mediated by G proteins, influencing cellular responses to various stimuli.
- **Neurobiology:** Potential involvement in neuronal signaling pathways; GPCRs are crucial in neurotransmitter systems.
- **Metabolic regulation:** GPCRs often modulate metabolic pathways, although the specific role of GPR156 is yet to be elucidated.

GPR156’s exact functions, pathways, and biological roles are still largely unexplored; further research is needed to define its contributions to health and disease comprehensively. 

### Conclusion
In summary, GPR156 is an orphan GPCR with uncertain roles in various biological processes. Its associations with aging or specific diseases remain largely to be defined. Future research may shed light on its potential interactions and applications, particularly in pharmacology and therapeutic interventions targeting related pathways.