### PPIL3 Gene Overview

**Gene Symbol:** PPIL3  
**Location:** Human chromosome 22  
**Function:** The PPIL3 gene encodes a member of the cyclophilin family, specifically a peptidyl-prolyl isomerase. Cyclophilins such as PPIL3 facilitate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. In addition to chaperoning protein folding, PPIL3 is implicated in the regulation of pre-mRNA splicing.

### 1. Associated Genes

PPIL3 has been associated with various other genes, including:

- **PPIL1 (Peptidyl-Prolyl Isomerase Like 1):** Another member of the cyclophilin family that shares structural and functional similarities with PPIL3.
- **SRSF proteins (Serine/Arginine Rich Splicing Factor):** This family of proteins is integral to the splicing process and may interact with PPIL3 in the context of pre-mRNA splicing.
- **PRPF proteins (Pre-mRNA Processing Factor):** Associated with premRNA splicing, they may functionally interact with PPIL3 due to its roles in similar processes.

### 2. Aging and Age-Related Diseases

Research regarding PPIL3's involvement in aging and age-related diseases is still emerging, but here are some highlights:

- **Cellular Senescence:** Preliminary studies suggest that cyclophilins may play roles in cellular stress responses that influence aging.
- **Cancer:** Some studies indicate that dysregulation of splicing factors can lead to cancer. As PPIL3 is involved in pre-mRNA splicing, alterations in its function may be relevant to tumorigenesis and cancer progression.
- **Neurodegenerative Diseases:** There is an interest in how cyclophilins may affect age-related neurodegenerative diseases such as Alzheimer's, though direct evidence linking PPIL3 to such diseases remains sparse.

### 3. Drug Interactions

PPIL3 may interact with various drugs, particularly those within classes related to:

- **Immunosuppressants:** Examples include Cyclosporin A, which inhibits cyclophilins and may influence their function.
- **Antiviral Drugs:** Certain antiviral medications that target cellular processes may indirectly interact with PPIL3 by affecting protein folding or splicing pathways.

### 4. Pathways and Biological Processes

PPIL3 is involved in several significant biological processes and pathways:

- **Protein Folding and Chaperone Activity:** As a peptidyl-prolyl isomerase, PPIL3 enhances protein folding efficiency, which is critical for maintaining cellular homeostasis.
- **Pre-mRNA Splicing:** PPIL3 is thought to be involved in the spliceosome complex, influencing mRNA processing, particularly splicing mechanisms.
- **Cell Cycle Regulation:** Given its role in protein modification and folding, PPIL3 may be indirectly involved in regulating the cell cycle and overall cell proliferation.

### Conclusion

The PPIL3 gene encodes a functionally critical protein implicated in multiple cellular processes, particularly related to protein folding and splicing. Its associations with certain pathological conditions, potential roles in aging, and interactions with drugs underscore its relevance in both molecular biology and clinical contexts. Future research may provide deeper insights, especially concerning age-related diseases and therapeutic targeting.