### UBE2N Gene Overview

**Gene Symbol:** UBE2N  
**Location:** Chromosome 10  
**Function:** UBE2N is a member of the ubiquitin-conjugating enzyme family that predominantly catalyzes the formation of 'Lys-63'-linked polyubiquitin chains, playing a crucial role in various cellular processes such as DNA repair, transcriptional regulation, and the immune response.

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### 1. Associated Genes
While the summaries highlighted several associated genes, particularly E3 ligases and key proteins involved in DNA repair and inflammation, UBE2N is also associated with:

- **UBE2V1**: Forms a heterodimer with UBE2N for non-canonical ubiquitination.
- **PCNA**: Involved in DNA replication and repair.
- **RNF5**: E3 ligase that collaborates in ubiquitinating JKAMP.
- **TRIM5**: Involved in the antiviral response.
- **TRAF3IP2**: E3 ligase that mediates interactions in IL-17 signaling.
  
Additionally, UBE2N may interact with other members of the E2 enzyme family, as well as various E3 ligases not explicitly stated in the summaries, such as **RIPK1**, which is involved in NF-kappa-B signaling and apoptosis.

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### 2. Aging and Age-Related Diseases
Research has suggested that UBE2N is involved in cellular stress responses and DNA repair mechanisms, processes that are critically important in aging. 

- **DNA Damage and Repair**: Given its role in error-free DNA repair pathways, deficiencies in UBE2N may be linked to age-related genomic instability, a hallmark of aging.
  
- **Inflammation**: The activation of NF-kappa-B through UBE2N's involvement in the polyubiquitination processes may connect to chronic inflammation, which is known to exacerbate age-related diseases.

- **Cancer**: Increased expression of UBE2N has been observed in several cancers, potentially linking it to age-associated oncogenesis due to the accumulation of DNA damage over time.

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### 3. Drug Interactions
Currently, there are no specific drugs directly targeting UBE2N, but it may be implicated in pathways modulated by various drug classes, notably:

- **Proteasome Inhibitors**: Since UBE2N is involved in ubiquitination processes linked to proteasomal degradation pathways, drugs like Bortezomib (a proteasome inhibitor used in multiple myeloma) indirectly affect UBE2N's focal processes.

- **Corticosteroids**: Drugs that modulate inflammation (such as dexamethasone) may influence pathways involving UBE2N, particularly in cases of chronic inflammatory diseases where NF-kappa-B is relevant.

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### 4. Pathways and Biological Processes
UBE2N is involved in several key biological pathways, including but not limited to:

- **Ubiquitin-Proteasome Pathway**: Critical for protein degradation and regulation of various cellular processes.
  
- **DNA Repair Pathways**: Especially error-free repair mechanisms such as homologous recombination and specific repair pathways responding to DNA damage.

- **NF-kappa-B Signaling**: Plays a significant role in inflammatory responses and immune regulation.

- **Cell Cycle Progression**: Involvement in checkpoints and transitions during the cell cycle, especially in response to DNA damage.

- **Antiviral Response**: Involvement in the RIG-I signaling pathway, leading to the activation of IFN-beta production in response to viral infections.

- **Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway**: Influences various cellular responses including inflammation and apoptosis.

Overall, UBE2N plays a versatile role in regulating various cellular functions, making it a critical component in maintaining cellular homeostasis, particularly under stress conditions such as DNA damage and inflammation.