The ACTR8 gene encodes a protein that is part of the INO80 chromatin remodeling complex, which plays critical roles in various cellular processes, including DNA repair and regulation of transcription. Below is an expanded summary of ACTR8, including its associations, links to aging, drug interactions, and pathways.

### 1. **Associated Genes**
While specific gene associations may not be directly mentioned in common summaries, the ACTR8 gene has been shown to interact with various other proteins within the INO80 complex and other chromatin remodeling complexes. Notable genes that could be associated due to their shared pathways include:
   - **INO80** (INO80 complex subunit)
   - **SNF2H** (a member of the ATP-dependent chromatin remodeling protein family)
   - **BRCA1/BRCA2** (associated with DNA repair mechanisms)
   - **RAD51**, which plays a role in homologous recombination during DNA repair.

### 2. **Aging and Age-related Diseases**
Though specific research on ACTR8's direct association with aging is limited, chromatin remodeling has been implicated in various aspects of aging. Disruption in chromatin structure and function can lead to genomic instability, which is a hallmark of aging and age-related diseases such as cancer. Furthermore, mutations or dysregulation of chromatin remodeling genes, including those in the INO80 complex, may contribute to the development or progression of age-related disorders.

### 3. **Drug Interactions**
As of October 2023, specific drugs directly targeting ACTR8 may not be widely documented, but potential interactions can occur through the modulation of its associated pathways. General classes of drugs that may influence chromatin remodeling processes include:
   - **Histone deacetylase inhibitors (HDAC inhibitors)** – these drugs modulate chromatin structure and may affect the function of complexes like INO80.
   - **ATPase inhibitors** – since ACTR8 exhibits low ATPase activity, compounds targeting ATPase functions could indirectly influence ACTR8-related processes.

### 4. **Pathways and Biological Processes**
ACTR8 is involved in several critical biological processes:
   - **Chromatin remodeling**: Facilitates the dynamic alteration of chromatin structure, essential for transcriptional regulation, DNA repair, and replication.
   - **DNA double-strand break repair**: Acts as a component of the machinery that repairs harmful breaks in DNA.
   - **Cell cycle regulation**: Involved in the functional organization of mitotic chromosomes, impacting cellular division.
   - **Gene expression regulation**: Plays a role in regulating transcription in a DNA-templated manner.

### Additional Notes
Given that ACTR8 is a component of the INO80 complex, studying its functions may provide insights into broader mechanisms of chromatin remodeling and their implications in cellular function, disease, and potentially aging. Further research, particularly in the context of aging and pathology, could reveal more about its roles and interactions.