### ARRDC2 Gene Overview

**Gene Symbol**: ARRDC2  
**Location**: Human Chromosome 14  
**Function**: The ARRDC2 gene encodes a member of the arrestin domain-containing protein family. The protein is predicted to be involved in protein transport and is primarily located in cytoplasmic vesicles and the plasma membrane. It has been noted for its interaction with the WWP1 protein through WW domains, suggesting a role in various cellular signaling pathways.

### 1. Associated Genes

- **WWP1**: The protein WWP1 is a known interacting partner that plays roles in ubiquitination and protein degradation.
- **ARRDC1**: Another member of the arrestin domain-containing protein family, potentially sharing functions in cellular signaling and protein sorting.
- Other genes involved in related signaling pathways or cellular transport mechanisms may also be co-expressed or implicated in studies but are not specifically highlighted in the summaries provided.

### 2. Aging and Age-related Diseases

While specific studies directly linking ARRDC2 to aging or age-related diseases might be limited, there are a few potential associations worth noting:

- **Cellular Stress Response**: Altered protein transport processes involving ARRDC2 may affect cellular stress responses, which are known to play critical roles in aging and the cellular aging process.
- **Cancer**: Some research suggests that mutations or dysregulations in the arrestin domain-containing protein family (including ARRDC2) could play roles in oncogenic processes, which often correlate with aging and age-related pathologies.

### 3. Drug Interactions

Currently, there is no comprehensive list of specific drugs or drug classes known to directly interact with the ARRDC2 gene. However, given its role in protein transport and signaling pathways, it may be influenced indirectly by various pharmacological agents that target pathways involved in cellular transport or ubiquitination.

### 4. Pathways and Biological Processes

ARRDC2 is involved in several biological processes and pathways, including:

- **Protein Transport**: ARRDC2 is predicted to play a role in the transport of proteins within the cell, particularly in sorting and possibly trafficking proteins between cellular compartments.
- **Ubiquitin-mediated Proteolysis**: Through its interaction with WWP1, ARRDC2 may be linked to the ubiquitin-proteasome pathway, which is crucial for protein degradation and quality control of proteins.
- **Regulation of Receptor Signaling**: The arrestin domain in ARRDC2 suggests a possible function in regulating receptor activity, potentially influencing signaling cascades downstream of receptor activation.

### Summary

In summary, the ARRDC2 gene is involved in critical intracellular transport functions and interacts with other proteins associated with ubiquitination. Although direct links to aging and age-related diseases are not extensively characterized, its roles in stress responses and potential implications in cancer highlight its importance in cellular health and disease. Further investigation into specific drug interactions and its complete functional pathways would provide a more comprehensive understanding of its biological significance.