### TPI1P2 Gene Information

**Gene Symbol:** TPI1P2 

**Overview:** TPI1P2 is a pseudogene related to the TPI1 (triosephosphate isomerase 1) gene, which encodes an enzyme involved in glycolysis. This gene is thought to have arisen from gene duplication of TPI1 and exhibits sequence similarity but typically lacks functional protein-coding capability.

#### 1. Associated Genes
TPI1P2 is primarily associated with its parent gene TPI1. Other related genes may include:
- **TPI1:** The functional gene encoding triosephosphate isomerase.
- **GAPDH (Glyceraldehyde 3-phosphate dehydrogenase):** Sometimes mentioned in the context of metabolic flux and energy production, as it interacts with pathways involving triose phosphates.
- **ALDOA (Aldolase A):** Another enzyme involved in glycolytic pathway regulation.

#### 2. Aging and Age-Related Diseases
As a pseudogene, TPI1P2 itself may not be directly linked to aging or specific age-related diseases in a functional context. However, because it is closely related to TPI1, which plays a significant role in glycolysis and cellular metabolism, perturbations in metabolic processes, including those linked to TPI1, can influence aging and age-related diseases like:
- **Neurodegenerative diseases:** Impaired energy metabolism can affect neuronal function.
- **Diabetes:** Disruption in metabolic pathways can have implications in insulin resistance.

Further research would be required to elucidate any indirect effects or associations that TPI1P2 might have in these conditions.

#### 3. Drug Interactions 
TPI1P2 is a pseudogene and does not have known direct drug interactions. However, drugs targeting the glycolytic pathway or metabolic processes related to TPI1 might indirectly influence the cellular context in which TPI1P2 is situated. Some classes of drugs to consider include:
- **Metformin:** Used in diabetes management, impacting metabolic pathways.
- **Glycolysis inhibitors:** Such as 2-Deoxy-D-glucose (2-DG), which affect glucose metabolism.

It's crucial to note that any drug associations would likely pertain to altered expression of TPI1 rather than the pseudogene itself.

#### 4. Pathways and Biological Processes
TPI1P2 does not participate in biological processes directly due to its pseudogenic status. However, the TPI1 protein is integral to:
- **Glycolysis:** Specifically in the interconversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.
- **Energy metabolism:** Overall carbohydrate metabolism, which influences ATP production.

In summary, while TPI1P2 itself may not directly participate in physiological processes, its historical and genetic relationship with TPI1 connects it to pathways of energy metabolism, which remain crucial for aging and metabolic diseases. Further functional studies would be necessary to delineate any emergent roles, if any, TPI1P2 might have in these contexts.