### TMEM130 Gene Overview

**Gene Symbol:** TMEM130  
**Location:** Golgi apparatus  
**Summary:** TMEM130 encodes a protein that is likely involved in the structure and function of the Golgi apparatus. It has been computationally mapped to include two potential isoforms.

### 1. Associated Genes
TMEM130 has been associated with several other genes, including:
- **PARK2** (Parkin RBR E3 ubiquitin protein ligase): Related to Parkinson's disease and is often mentioned in conjunction with TMEM130 in neurodegenerative studies.
- **PINK1** (PTEN induced putative kinase 1): Another gene involved in Parkinson's disease; shares a connection regarding mitochondrial quality control.
- **DJ-1 (PARK7):** A gene associated with protection against oxidative stress and linked to familial forms of Parkinson's disease.
  
These associations suggest that TMEM130 may play a role in the pathology of neurodegenerative diseases.

### 2. Aging and Age-Related Diseases
- **Neurodegeneration:** While specific studies directly linking TMEM130 with aging are limited, its associations with PARK2 and PINK1 indicate possible implications in age-related neurodegenerative conditions such as Parkinson's disease.
- **Potential Molecular Mechanisms:** TMEM130 might be involved in protein trafficking and quality control processes in the Golgi apparatus, which can deteriorate with age, leading to cellular dysfunction.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly target TMEM130 are not well documented in the literature. However, drugs aimed at neuroprotective pathways related to Parkinson's disease and mitochondrial health may indirectly impact TMEM130's role, especially considering its connections with PARK2 and PINK1:
- **Neuroprotective Agents:** Such as those targeting mitochondrial function or oxidative stress pathways may be relevant.
- **Antioxidants:** General antioxidant drugs could also be considered in the context of neurodegeneration.

### 4. Pathways and Biological Processes
TMEM130 is involved in several pathways and biological processes that highlight its functional roles:

- **Protein Processing in the Endoplasmic Reticulum (ER):** TMEM130 may have a role in the proper maturation and trafficking of proteins, crucial for maintaining cell function.
- **Golgi Apparatus Functionality:** It has an essential role in the Golgi apparatus, suggesting involvement in protein sorting and secretion processes.
- **Mitochondrial Quality Control:** Given its associations with genes linked to mitochondrial health, it might play a part in the clearance of damaged mitochondria.

### Summary
TMEM130 is a gene linked to the Golgi apparatus function, with potential implications in aging and neurodegenerative disease, particularly through its interactions with other key genes in these pathways. Research continues to elucidate its specific mechanisms and roles in age-related contexts and drug interactions.