### THSD4-AS1 Gene Overview

**Gene Symbol:** THSD4-AS1  
**Location:** Located on chromosome 3 in humans, THSD4-AS1 is an antisense long non-coding RNA (lncRNA) known to play a role in various biological processes, including gene regulation and cellular differentiation.

### 1. Associated Genes
THSD4-AS1 is known to be associated with several genes and typically functions in the regulation of adjacent or nearby genes. Alternative mRNA splicing linked with THSD4-AS1 may involve its neighboring genes, such as THSD4 (Thrombospondin Type 1 Domain Containing 4). Other genes that may interact or be co-regulated in similar pathways might include those related to angiogenesis and tissue remodeling. However, specific additional genes directly associated with THSD4-AS1 are less commonly noted in the literature and may require further investigation or experimental validation.

### 2. Aging and Age-Related Diseases
As of October 2023, there is limited direct research connecting THSD4-AS1 to aging or age-related diseases specifically. Nonetheless, lncRNAs, including THSD4-AS1, have been implicated in modulating processes such as inflammation, cell proliferation, and apoptosis, which are essential in the context of aging and age-related pathologies such as cancer and cardiovascular diseases. If THSD4-AS1 plays regulatory roles in certain biological pathways or cellular functions associated with these diseases, it would warrant attention as a potential biomarker or therapeutic target.

### 3. Drug Interactions
Information regarding specific drugs or drug classes that interact with THSD4-AS1 may be limited, as lncRNAs are less commonly targeted directly by pharmaceuticals compared to protein-coding genes. However, lncRNAs can influence the expression of genes that are related to drug metabolism and efficacy. Research might reveal indirect pathways whereby THSD4-AS1 could impact responses to certain pharmacological agents, particularly in cancer treatment where lncRNA dysregulation is prevalent.

### 4. Pathways and Biological Processes
THSD4-AS1 is involved in several biological processes, including:
- **Gene regulation:** lncRNAs like THSD4-AS1 are known to interact with chromatin and transcription factors, influencing gene expression patterns, often in a tissue-specific manner.
- **Cell differentiation:** It may play a role in cellular differentiation processes, particularly in vasculature or connective tissue.
- **Angiogenesis:** Given its ties to THSD4, which has roles in vascular remodeling, THSD4-AS1 might also participate in the processes governing new blood vessel formation.

In summary, while THSD4-AS1 is a long non-coding RNA with regulatory potential in gene expression and biological processes, further studies are required to elucidate its specific roles, associations with other genes, and implications in aging and therapeutics more comprehensively.