### RRP1 Gene Overview

**Gene Symbol**: RRP1  
**Function**: The RRP1 gene encodes a protein that is homologous to the yeast ribosomal RNA processing protein RRP1. This protein is suspected to have a role in the processing of ribosomal RNA, particularly in the late stages of nucleologenesis during the completion of mitosis, and is critical for the generation of 28S rRNA.

### 1. Associated Genes
While specific gene associations can vary depending on context, the following are notable:
- **RRP1B**: A gene that encodes a similar protein and might share functional pathways with RRP1.
- **RPL11, RPL23, RPL35**: These ribosomal protein genes are involved in ribosome assembly and may have regulatory interplay with RRP1's function in rRNA processing.
- **NOP10, NOP58**: These are involved in the nucleolar processing and maturation of rRNA and might have a functional relationship with RRP1.

### 2. Aging and Age-Related Diseases
The role of RRP1 in ribosomal RNA processing links it to cellular growth and proliferation. Changes in ribosomal biogenesis have been implicated in aging and age-related diseases. 

- **Cellular Senescence**: Disruption in ribosomal function can lead to cellular senescence, a hallmark of aging. High levels of ribosomal RNA processing proteins like RRP1 may influence the rate of senescence.
- **Cancer**: Alterations in ribosomal proteins and rRNA synthesis pathways can contribute to tumorigenesis. Some studies suggest that ribosome biogenesis is dysregulated in various cancers, potentially implicating RRP1 in tumor development or progression.
  
Though specific associations with age-related diseases are less well-documented, its involvement in these biological processes suggests a potential indirect role concerning aging.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes that are directly reported to interact with the RRP1 gene product in well-cataloged databases. However, given its involvement in ribosome biogenesis, drugs affecting RNA synthesis or general cell proliferation, such as certain chemotherapy agents, may have indirect effects. For instance:
- **Ribosome synthesis inhibitors**: Drugs such as rocaglamide, which target the ribosome, may modify the activity connected to RRP1 indirectly.

### 4. Pathways and Biological Processes
The RRP1 gene is involved in several critical pathways and biological processes, including:

- **Eukaryotic Translation**: Participation in pathways pertinent to ribosomal assembly and function.
- **Nucleolar Organization**: Involvement in the formation and maintenance of the nucleolus during mitosis.
- **Ribosomal RNA Processing**: Key roles in the maturation and processing of rRNA, specifically for 28S rRNA.
- **Cell Cycle Regulation**: Implicates participation in the regulation of cellular events during the cell cycle, particularly in the late stages of mitosis.

RRP1's function in forming mature ribosomes is crucial for protein synthesis, linking it to fundamental cellular processes that are tightly regulated throughout the cell cycle.

### Summary
The RRP1 gene is crucial for 28S rRNA generation and nucleolar assembly during cell division. Its association with ribosomal protein genes highlights its importance in ribosome biogenesis. Research into its links with aging and disease, especially cancer, is warranted, but definitive drug interactions remain under-explored.