### ACTR1AP1 Gene Overview

**Gene Symbol:** ACTR1AP1 (Actin Cytoskeletal Regulator 1A-Associated Protein 1)  
**Chromosomal Location:** The ACTR1AP1 gene is located on chromosome 1, and it encodes a protein that is involved in various cellular processes.

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### 1. Associated Genes

While the NCBI and UniProt summaries often highlight specific interactions, additional genes associated with ACTR1AP1 include:

- **ACTR1A:** The ACTR1A gene encodes a protein that is part of the same complex as ACTR1AP1 and plays a role in cytoskeletal organization.
- **CENPF (Centromere Protein F):** This gene is important for chromosome segregation in mitosis and has been implicated in interactions with proteins involved in cellular transport processes.
- **KIF2C (Kinesin Family Member 2C):** This gene encodes a member of the kinesin family, which is involved in the transport of various cellular components, possibly including those mediated by ACTR1AP1.

These interactions highlight a role for ACTR1AP1 in cellular motility and transport alongside its associated partners.

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### 2. Aging and Age-Related Diseases

Current literature may not have abundant direct evidence linking ACTR1AP1 to aging or age-related diseases. However, the following points are relevant:

- **Cellular Transport and Aging:** As ACTR1AP1 is involved in cytoskeletal organization and intracellular transport, dysregulation of these processes can lead to age-related decline in cellular function. Alterations in cytoskeleton structure are observed in aging cells.
- **Neurodegenerative Diseases:** Given the association with cellular transport mechanisms, there is a potential link to neurodegenerative diseases (e.g., Alzheimer's disease) where disruptions in protein trafficking contribute to pathology. Further research is warranted to clarify any definitive associations with aging processes or specific age-related diseases.

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### 3. Drug Interactions

As for known drugs or drug classes that interact with ACTR1AP1, there is no direct evidence from major drug databases explicitly linking any specific drugs to ACTR1AP1. However, in the context of research and development, compounds that target cytoskeletal dynamics, such as:

- **Microtubule-inhibiting agents (e.g., Taxanes, Vinca Alkaloids):** These are known to interact broadly with cytoskeletal reorganization and may affect pathways involving ACTR1AP1 indirectly.

Future drug development targeting related pathways may provide insights into therapeutic implications.

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### 4. Pathways and Biological Processes

ACTR1AP1 is involved in several key biological pathways, including:

- **Microtubule Dynamics:** As a regulator, ACTR1AP1 plays a role in the stabilization and dynamics of microtubules, which is vital for cellular processes like mitosis and intracellular transport.
- **Cytoskeletal Organization:** The protein aids in maintaining the structure and function of the cytoskeleton, influencing cell shape and motility.
- **Intracellular Transport:** Associated with the transport mechanisms involving kinesins, which are essential for the proper localization of organelles and proteins within the cell.

Additional stress response and vesicle transport pathways may also be influenced by ACTR1AP1, although more specific connections remain areas for further research.

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### Conclusion

ACTR1AP1 encodes a protein critical for cytoskeletal organization and intracellular transport, potentially linking it to aging and neurodegenerative processes, although more detailed studies are necessary to uncover these relationships. Its interactions with related partners and pathways manifest its importance in cell physiology, and while no specific drug interactions have been conclusively identified, ongoing research may unveil new therapeutic targets.