The **SNORD65B** gene is a part of the small nucleolar RNA (snoRNA) family. These molecules play essential roles in the modification and processing of ribosomal RNA (rRNA) and are crucial for proper ribosome function. The snoRNAs generally function in the nucleolus, where they are involved in guiding chemical modifications to rRNA, mainly through methylation and pseudouridylation.

### 1. Associated Genes:
While specific associations can vary based on the context and the research available, **SNORD65B** is part of a larger family of snoRNAs and may share functional associations with other similar snoRNA genes like:
- **SNORD65**: An orthologous snoRNA that serves related functions in rRNA processing.
- Other snoRNA genes that reside within clusters, which may exhibit co-expression patterns and regulatory similarities, such as members of the C/D box and H/ACA box snoRNA families.

### 2. Aging and Age-Related Diseases:
Research surrounding **SNORD65B** specifically in the context of aging is limited; however, the general role of snoRNAs in ribosomal biogenesis and cellular aging cannot be underestimated. Aberration in snoRNA function has been implicated in:
- **Cancer**: Altered expression or mutations in snoRNA genes can influence cell proliferation and oncogenic processes.
- **Neurodegenerative Disorders**: Altered snoRNA expression has been linked to diseases such as Alzheimer’s and Parkinson’s, which are age-related.
- The regulation and modification of rRNA by snoRNAs are vital for maintaining cellular homeostasis, which may contribute to the aging process. Inappropriate modifications could lead to decreased ribosome efficiency and cellular senescence.

### 3. Drug Interactions:
Currently, there are no specific drugs or drug classes that are known to directly interact with or target the **SNORD65B** gene specifically. However, because snoRNAs are involved in the processing of rRNA, drugs that impact ribosome function or rRNA modifications indirectly might affect the pathways associated with this gene. Chemotherapeutic agents targeting the ribosome or its biogenesis, such as:
- **Antibiotics** (e.g., Macrolides, Tetracyclines) might have generalized effects on snoRNA activity within cells—but these interactions are not direct.

### 4. Pathways and Biological Processes:
**SNORD65B** is involved in several biological processes, including:
- **Ribosome Biogenesis**: Participating in the chemical modification of pre-rRNA, which is essential for the formation of functional ribosomes.
- **rRNA Methylation**: In this process, snoRNAs guide methyltransferases to specific nucleotides in rRNA to modify them, which influences ribosome assembly and function.
- **Cell Cycle Regulation**: Proper ribosome function is necessary for efficient protein synthesis, which in turn regulates cell growth and division.

In terms of pathways, **SNORD65B** might be part of larger RNA processing pathways, particularly those associated with:
- **Nuclear RNA Processing**: Involving splicing, cap methylation, and polyadenylation processes, which are related to gene expression regulation.
- **Non-coding RNA-mediated processes**: These include regulatory networks where various non-coding RNAs interact with RNA-binding proteins.

In summary, while **SNORD65B** is characterized primarily as a snoRNA involved in rRNA biogenesis, its broader implications in age-related biological processes and its potential indirect interactions with drugs are valuable aspects of ongoing research in the field of genetics and bioinformatics.