### COMMD3 Gene Overview

**Gene Symbol:** COMMD3

**Predicted Function:**
- Involved in sodium ion transport and may play a role in the regulation of the epithelial sodium channel (ENaC).
- Modulates activity of cullin-RING E3 ubiquitin ligase (CRL) complexes, influencing protein degradation pathways.
- Down-regulates the activation of NF-kappa-B, a key transcription factor involved in immune response and inflammation.

**Predicted Location:**
- Extracellular region and ficolin-1-rich granule lumen.

### Additional Associated Genes
While the summaries provided do not mention specific genes directly associated with COMMD3, it is known to interact with several other genes and proteins related to ion transport and NF-kappa-B signaling, such as:
- **ENaC (Epithelial Sodium Channel):** Specific subunits of ENaC (e.g., SCNN1A, SCNN1B, SCNN1G) may exhibit regulatory interactions with COMMD3.
- **Other COMMD family members:** This gene is part of the COMMD protein family, which includes COMMD1, COMMD2, etc., that share functional similarities and may interact with one another.

### Aging and Age-Related Diseases
While specific studies directly linking COMMD3 to aging or age-related diseases may be limited, its involvement in sodium transport and NF-kappa-B regulation suggests that it could have implications in:
- **Hypertension and Cardiovascular Diseases:** Dysregulation of sodium transport can lead to hypertension, which is often associated with aging.
- **Inflammatory Conditions:** As NF-kappa-B signaling is implicated in chronic inflammation, variations in COMMD3 activity may influence age-related inflammatory diseases.
- **Kidney Function:** Given the role of COMMD3 in regulating sodium channels, it may have implications in kidney disease, particularly as renal function declines with age.

### Drug Interactions
Currently, there is limited specific data on drugs directly targeting COMMD3. However, drugs affecting pathways related to:
- **Sodium channels:** Such as diuretics or ENaC inhibitors may indirectly interact with the functional outputs of COMMD3.
- **NF-kappa-B inhibitors:** Drugs that target inflammation (like corticosteroids) may have downstream effects on COMMD3 activity due to its role in NF-kappa-B modulation.

### Pathways and Biological Processes
COMMD3 is involved in several key biological pathways:
- **Endocytic Recycling:** Plays a role in the recycling of the ENaC complex to the cell surface, regulating sodium absorption in epithelial cells.
- **Ubiquitin-Proteasome Pathway:** Through its modulation of CRL complexes, it participates in the degradation of regulatory proteins, influencing several cellular processes.
- **Inflammatory Response Pathway:** By down-regulating NF-kappa-B activation, it influences cytokine signaling and immune responses.
- **Ion Homeostasis:** Direct involvement in the regulation of sodium transport contributes to maintaining ion balance in various physiological contexts.

In summary, COMMD3 has multifaceted roles in sodium transport and ubiquitin-mediated protein regulation, with potential implications for aging and various health conditions. Continued research may further elucidate its significance in specific disease contexts and therapeutic opportunities.