### WDR64 Gene Overview

The **WDR64** gene (WD repeat domain 64) encodes a protein that is part of the WD repeat protein family, characterized by the presence of WD repeats—a specific motif that serves as a protein-protein interaction domain. These proteins generally are involved in a variety of cellular processes, including signal transduction, cell cycle regulation, and gene expression.

#### 1. Associated Genes

While direct associations can vary based on specific studies and databases, some genes that may be functionally or contextually related to WDR64 include:

- **TP53**: p53 is a well-known tumor suppressor gene, and proteins in the WD repeat domain family, including WDR64, can be implicated in various pathways affecting cell cycle and apoptosis.
- **MTOR**: The mechanistic target of rapamycin is involved in cell growth and metabolism, and it can be affected by the activity of WD-repeat proteins.
- **CDK**: Cyclin-dependent kinases often have interactions with proteins involved in cell cycle regulation and could have associations through pathways where WDR64 is active.

##### Note: Specific detailed interactions can differ in different biological contexts.

#### 2. Aging and Age-Related Diseases

As of the latest data up to October 2023, **WDR64** does not have extensive established connections to aging or age-related diseases in the literature. However, given its potential roles in cell cycle regulation and signal transduction, there may be implications in the context of:

- Cellular senescence: Any disruptions in cell cycle regulation can contribute to senescence, a state associated with aging.
- Cancer: Aberration in WD-repeat containing proteins can be linked to oncogenic processes, which are often more prevalent with increasing age.

There may be emerging research connections, but specific direct associations with age-related diseases like Alzheimer's or cardiovascular conditions are not well-documented at this time.

#### 3. Drug Interactions

Currently, there aren't widely recognized drugs or drug classes specifically targeting or interacting with the **WDR64** gene or its protein product. However, general pathways involving phosphoinositide 3-kinase (PI3K) and mTOR signaling, where WDR proteins might be functionally relevant, could relate to drug classes such as:

- mTOR inhibitors (e.g., rapamycin)
- PI3K inhibitors (e.g., idelalisib, copanlisib, etc.)

Research is ongoing, and it is worth keeping an eye on emerging studies to explore specific pharmacogenomic interactions that might be insightful.

#### 4. Pathways and Biological Processes

**WDR64** is known to participate in several biological processes, including but not limited to:

- **Cell Cycle Regulation**: Involvement in cell proliferation pathways where protein interactions and complex formations are essential.
- **Signal Transduction**: Engaging in signaling pathways that could influence several outcomes, including cellular responses to external stimuli.
- **Transcriptional Regulation**: Potential participation in pathways that manage gene expression, possibly through interactions with other proteins.

The exact pathways can be context-specific, and ongoing research may identify further roles for WDR64 in various cellular mechanisms or conditions.

### Conclusion

WDR64 plays a vital role in cellular processes through its protein interactions but does not have extensive direct associations with aging and age-related diseases or known drug interactions as of the latest updates. Its functions in cell cycle and signal transduction pathways suggest potential implications in various biological contexts, warranting further investigation, especially given the breadth of roles WD-repeat proteins typically fulfill in biological systems.