### SLC13A3 Gene Overview

**Gene Symbol**: SLC13A3  
**Location**: Chromosome 22  
**Protein**: Sodium-dicarboxylate cotransporter 3 (NaDC3)

### General Function
SLC13A3 encodes a high-affinity sodium-dicarboxylate cotransporter, primarily responsible for the reabsorption of dicarboxylates and citrate in the kidneys. This protein plays a crucial role in regulating the balance of organic acids and facilitating metabolic processes associated with the citric acid cycle.

### Associated Genes
SLC13A3 does not have extensively characterized associations with specific genes beyond those involved in renal function and metabolism. However, it may interact indirectly with genes involved in:
- **Metabolic pathways** (e.g., those related to citrate metabolism).
- **Sodium/ion transport** (such as SLC9A3 which encodes for the sodium/hydrogen exchanger).
- **Cellular energy regulation genes**, like those involved in mitochondrial function.

### Aging and Age-Related Diseases
While direct associations between SLC13A3 and aging or age-related diseases are not fully delineated, alterations in citrate and dicarboxylate metabolism can impact:
- **Kidney function**, with implications for conditions like chronic kidney disease (CKD), which is more prevalent in aged populations.
- **Metabolic syndromes**, wherein disrupted citrate transport and energy metabolism can lead to obesity or diabetes, conditions that carry greater risk as age increases.

Potential links to aging and related diseases might include:
- **Renal health**: Changes in SLC13A3 expression or function could impact kidney health and overall metabolic control in older adults.
- **Mitochondrial function**: Impaired transport of TCA intermediates may contribute to mitochondrial dysfunction observed with aging.

### Drug or Drug Classes
Currently, there are no specific drugs or drug classes universally recognized for direct interaction with SLC13A3. However, due to its role in organic acid transport, potential indirect interactions may exist with:
- **Diuretics**: Since they influence renal function and electrolyte balance.
- **Metabolic agents**: Such as those aimed at optimizing energy metabolism or managing metabolic syndromes.

### Pathways and Biological Processes
SLC13A3 is involved in several biological processes and metabolic pathways, including:
- **Dicarboxylate transport**: Particularly involved in sodium-dependent transport of dicarboxylates like succinate and α-ketoglutarate.
- **Citrate metabolic process**: Participates in the transport of citrate for various metabolic activities.
- **Regulation of cellular pH**: Through the sodium-dependent co-transport mechanisms.
- **Kidney function**: Enhances renal reabsorption processes, ensuring proper acid-base balance.

### Conclusion
The SLC13A3 gene plays an essential role in the transport of dicarboxylates and citrate, contributing to metabolic processes and kidney function. While there are several indirect links to metabolism and potentially age-related conditions, ongoing research could further clarify its specific roles and implications in health and disease.