### VASH1 Gene Overview

**Gene Symbol**: VASH1  
**Location**: The VASH1 gene is located on chromosome 14 in humans.

### 1. Associated Genes
Apart from the key functions of VASH1, it may interact with or be associated with other genes involved in similar processes. Notable genes that are often studied in relation to VASH1 include:

- **VEGF** (Vascular Endothelial Growth Factor): Plays a crucial role in angiogenesis and may be negatively regulated by VASH1.
- **TP53** (Tumor Protein p53): Involved in cell cycle regulation and apoptosis.
- **TUBB** (Tubulin Beta Class I): Effects on microtubule dynamics may influence VASH1's function since VASH1 regulates alpha-tubulin.
- **MMPs** (Matrix Metalloproteinases): These are involved in extracellular matrix remodeling, where VASH1 may also play a role in the regulation of migration of endothelial cells.

### 2. Aging and Age-Related Diseases
The VASH1 gene has been implicated in age-related conditions:

- **Liver Cirrhosis**: VASH1 is a recognized biomarker for liver cirrhosis, a chronic condition often associated with aging.
- **Portal Hypertension**: The link between VASH1 and liver pathology suggests its role in disorders that can worsen with age due to fibrosis and vascular complications.
- **Angiogenesis**: Dysregulation of angiogenesis, influenced by VASH1, is often associated with age-related diseases such as cancer and cardiovascular diseases.

### 3. Drug Interactions
Though direct interactions between drugs and the VASH1 gene may not be thoroughly detailed, certain classes of drugs that target angiogenesis could potentially influence VASH1 activity:

- **Angiogenesis Inhibitors**: Anticancer drugs that inhibit angiogenesis, such as:
  - **Bevacizumab** (Avastin)
  - **Sorafenib** 
  - **Sunitinib**
- **Protease Inhibitors**: As VASH1 has metallocarboxypeptidase activity, certain protease inhibitors might indirectly influence its function.

### 4. Pathways and Biological Processes
The VASH1 gene is involved in several key biological pathways and processes, including:

- **Angiogenesis**: Negative regulation of angiogenesis, preventing excessive formation of blood vessels.
- **Endothelial Cell Migration and Proliferation**: VASH1 is crucial in inhibiting the migration and proliferation of endothelial cells, essential for angiogenic processes.
- **Microtubule Dynamics**: As a tyrosine carboxypeptidase, it regulates the dynamics of microtubules, which are critical for mitosis.
- **Cell Migration**: Involved in the regulation of cell migration beyond endothelial cells, impacting overall tissue homeostasis.
- **Proteolysis**: Enzymatic activity contributing to proteolytic processes that influence various signaling pathways.

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In summary, VASH1 is a multifaceted gene with critical roles in angiogenesis and microtubule dynamics, associated with important pathways related to endothelial function and aging-related diseases, particularly liver conditions. Its potential interactions with therapeutic agents further highlight its importance in disease modulation.