### 1. Associated Genes:

MIR105-2, being a microRNA, can exert regulatory effects on various target genes. While the specific associations may not be exhaustively detailed in the provided summaries, miRNAs commonly target multiple mRNAs across different biological pathways. Known targets of miR-105 (the mature form derived from MIR105-2) include genes involved in cell proliferation, apoptosis, and angiogenesis. Some potential targets associated with miR-105 include:

- **ZEB1** (Zinc Finger E-Box Binding Homeobox 1): A transcription factor involved in epithelial-mesenchymal transition.
- **VEGFA** (Vascular Endothelial Growth Factor A): Plays a critical role in angiogenesis.
- **PTEN** (Phosphatase and Tensin Homolog): Involved in regulating the cell cycle and preventing tumor progression.

### 2. Aging and Age-Related Diseases:

While direct evidence linking MIR105-2 specifically to aging or age-related diseases can be limited, studies involving miR-105 have suggested its involvement in several mechanisms pertinent to cancer and cellular senescence, processes that are often influenced by aging. For example:

- **Cancer**: Dysregulation of miRNAs, including miR-105, has been associated with various cancers, which are frequently age-related diseases.
- **Cellular Senescence**: Abnormal miRNA expression profiles during aging can contribute to cellular senescence, affecting tissue repair and regeneration.

Research is ongoing to clarify the role of specific microRNAs in aging and their potential therapeutic implications.

### 3. Known Drug or Drug Classes Interacting with MIR105-2:

The specific interactions of drugs or drug classes with MIR105-2 may not be fully explored in the literature. However, drugs that modify miRNA expression or function, such as small molecule inhibitors or mimetics, could theoretically affect the activity of this microRNA. Some examples include:

- **miRNA mimics**: These can be used to upregulate the levels of miR-105 in cases where it may be downregulated in disease contexts.
- **Antisense oligonucleotides (ASOs)**: These can specifically inhibit the action of miRNAs, which could provide a target for drug development.

More specific pharmacological interactions may be elucidated through ongoing research targeting miRNAs in therapeutic settings.

### 4. Pathways and Biological Processes:

MIR105-2 is involved in several key biological processes and pathways relevant to its function:

- **Gene Silencing**: As a microRNA, MIR105-2 plays a crucial role in post-transcriptional regulation, leading to mRNA degradation or inhibition of translation.
- **Developmental Processes**: miRNAs are essential in embryogenesis, cellular differentiation, and tissue homeostasis.
- **Cancer Progression**: Involvement in regulatory networks that contribute to cell proliferation, apoptosis, and invasion, especially in the context of tumor biology.
- **Angiogenesis**: Interaction with pathways associated with blood vessel formation, particularly through regulation of pro-angiogenic factors like VEGFA.

Overall, MIR105-2 is a microRNA with wide-ranging impacts on gene regulation, cellular functions, and its potential implications in aging and disease continue to be areas of active research.