The RHEBL1 gene, also known as Ras homolog enriched in brain-like 1, is a member of the Ras superfamily of GTPases. It is primarily involved in signal transduction pathways, particularly those related to the mTOR (mechanistic target of rapamycin) signaling pathway and regulation of NF-kappaB activity.

### 1. Associated Genes
RHEBL1 has been linked to several genes, including but not limited to:
- **RPS6KB1** (ribosomal protein S6 kinase B1): This gene is a downstream target of RHEBL1, involved in cell growth and proliferation.
- **TSC1** and **TSC2**: These genes encode proteins that function as a complex to inhibit mTOR signaling and are GTPase-activating proteins for small GTPases, which also includes RHEBL1.
- **AKT1**: Involved in various cellular processes, including metabolism, cell proliferation, and survival, which is influenced by RHEBL1 through mTOR signaling.
- **NF-kB1** (nuclear factor kappa B subunit 1): RHEBL1 may impact the activity of this transcription factor, which is crucial for immune response and inflammation.

### 2. Aging and Age-related Diseases
While specific research directly linking RHEBL1 to aging or age-related diseases is limited, its involvement in pathways such as mTOR signaling—which is closely associated with aging—suggests potential relevance. The mTOR pathway is known to regulate cellular growth, metabolism, and responses to nutrient availability, which are all important in the context of aging and age-related diseases. Dysregulation of the mTOR signaling pathway is implicated in conditions such as cancer, neurodegeneration, and metabolic disorders.

### 3. Drug Interactions
Currently, there are no specific drugs directly targeting RHEBL1 identified in the literature. However, agents that modulate the mTOR signaling pathway, such as:
- **Rapamycin** (Sirolimus), used as an immunosuppressant and known to extend lifespan in model organisms.
- **Metformin**, which has been associated with mTOR inhibition and is being investigated for its potential effects on aging and age-related diseases.
These drugs can indirectly affect RHEBL1's activity as they modulate the cellular pathways RHEBL1 is involved in.

### 4. Pathways and Biological Processes
RHEBL1 is involved in the following key biological processes and pathways:
- **mTOR signaling pathway**: Involving regulation of cell growth and proliferation.
- **NF-kappaB signaling pathway**: Playing a role in immune response, inflammation, and cell survival.
- **GTPase activity**: Contributing to various signal transduction pathways.
- **Cellular responses to nutrients**: Affecting metabolism and growth in response to nutrient status.

Overall, RHEBL1 plays a significant role in essential cellular processes that intersect with growth, metabolism, and responses to stress, linking it to both developmental and pathological processes, including cancer and potential age-related changes. Further research may illuminate more direct links between RHEBL1 and aging or specific age-related diseases.