**SNORA11B Gene Overview**

**Gene Symbol:** SNORA11B  
**Official Name:** Small Nucleolar RNA, H/ACA Box 11B  
**Gene Type:** Non-coding RNA  

**General Description:**  
The SNORA11B gene encodes a member of the small nucleolar RNA (snoRNA) family. These RNAs are primarily involved in the modification of ribosomal RNA (rRNA) and are critical for the proper processing and maturation of rRNA in nucleoli. Specifically, SNORA11B is classified within the H/ACA box snoRNA subfamily, which is known for its role in guiding pseudouridylation, a chemical modification that enhances the stability and functionality of rRNA.

### 1. Associated Genes
The SNORA11B gene may functionally interact with various other genes involved in ribosome biogenesis and RNA processing, particularly those encoding different snoRNAs and proteins involved in the nucleolar machinery. While specific studies detailing associated genes are limited, common snoRNA-interacting partners include:

- **RRP1B**: A ribosome biogenesis factor that interacts with snoRNAs.
- **NOP58** and **NOP60**: Components of the box C/D and H/ACA snoRNP complexes that may cooperate with SNORA11B in rRNA modifications.

### 2. Aging and Age-Related Diseases
While there aren't extensive reports specifically linking SNORA11B to aging or age-related diseases, snoRNAs like SNORA11B play a critical role in ribosome production and cellular metabolism, which are essential for maintaining tissue homeostasis. Defects in snoRNA function have been implicated in:

- **Cancer**: Abnormalities in ribosome biogenesis and RNA modifications can lead to increased cellular proliferation, a hallmark of many cancers.
- **Neurodegenerative Diseases**: As cellular stress increases with age, the disruption of nucleolar function, including that involving snoRNAs, has been linked to diseases like Alzheimer's and Parkinson's.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes that are documented to interact directly with the SNORA11B gene. Given its role as a non-coding RNA, targeting snoRNAs may require novel therapeutic approaches rather than traditional drug interactions. Research into RNA-targeted therapies is ongoing, and future insights may yield drugs that influence snoRNA functionalities.

### 4. Pathways and Biological Processes
The SNORA11B gene is primarily involved in the following biological processes:

- **Ribosome Biogenesis**: Acting as a guide for rRNA pseudouridylation, SNORA11B is pivotal in the maturation of ribosomal RNA, which is essential for ribosome assembly.
- **RNA Modification**: It plays a significant role in rRNA modification processes, crucial for proper translational function.
- **Nucleolar Organization**: Being a non-coding RNA localized in the nucleolus, it contributes to the architecture and organization of this critical nuclear substructure.

In summary, the SNORA11B gene is an essential component of the cellular machinery responsible for rRNA modification and ribosome biogenesis, with potential implications for understanding its role in aging and various diseases. Further research is required to elucidate its specific interactions and the broader biological context in which it operates.