### NFYC Gene Overview

**Gene Symbol**: NFYC  
**Location**: Chromosome 6 (human genome, specific location varies)  
**Function**: The NFYC gene encodes the C subunit of the NF-Y transcription factor complex, which is crucial for the transcriptional regulation of genes containing a CCAAT box in their promoter regions. NF-Y is a heterotrimeric complex composed of three subunits: NF-YA, NF-YB, and NF-YC. The NF-Y complex is involved in the regulation of various biological processes, including cell proliferation, differentiation, and response to stress.

### 1. Associated Genes

NFYC is known to interact and be associated with several other genes, including but not limited to:
- **NFYA**: The A subunit of the NF-Y complex, essential for its function.
- **NFYB**: The B subunit of NF-Y, which, along with NFYC, forms a dimer necessary for NF-YA interaction.
- **CCDC88C**: Involved in the regulation of cellular processes, potentially linked through transcriptional pathways.
- **CDK6**: Known for its role in cell cycle regulation, with potential cross-talk via NF-Y pathways.
- **KLF4**: A member of the Krüppel-like factor family, which is involved in cellular processes and may interact with NF-Y.

### 2. Aging and Age-Related Diseases

- **Cell Cycle Regulation**: NFYC has been implicated in the regulation of cell cycle genes, which could affect cellular senescence and aging.
- **Age-Related Diseases**: Abnormalities in NF-Y complex functioning have been linked to cancer and other diseases, possibly due to dysfunctional regulation of genes involved in apoptosis, proliferation, and DNA repair mechanisms.
- **Epigenetic Regulation**: Age-associated changes in NF-Y activity may influence gene expression patterns, contributing to various age-related phenotypes and diseases.

### 3. Drug Interactions

As of the latest data, there aren't specific drugs universally recognized to directly target NFYC. However, NF-Y is involved in many pathways related to various disease states, where indirect interactions may occur:

- **Chemotherapeutic Agents**: Some studies suggest that drugs targeting pathways regulated by the NF-Y complex may indirectly influence NFYC activity; these can include histone deacetylase inhibitors or other epigenetic modifying agents.
- **Transcription Modulators**: Agents that affect transcriptional regulation might impact NF-Y function, although specific drug classes targeting NFYC directly are still under research.

### 4. Pathways and Biological Processes

NFYC is involved in numerous critical biological pathways and processes, including:

- **Cell Cycle Regulation**: The NF-Y complex has roles in the transcriptional control of key cell cycle genes essential for proper cellular division.
- **DNA Damage Response**: NF-Y has been shown to regulate genes involved in DNA repair mechanisms, thereby having implications in cancer biology.
- **Development and Differentiation**: NF-Y is known to influence genes contributing to the normal development and differentiation of various cell types.
- **Stress Response**: The NF-Y complex is involved in mediating responses to stress conditions, potentially impacting cellular survival and function under stress.
- **Metabolic Regulation**: NF-Y may have roles in regulating metabolic pathways, including glucose and lipid metabolism.

### Conclusion

The NFYC gene is an essential component of the NF-Y transcription factor complex, influencing a broad range of biological processes critical for cellular function and health. Its interactions and regulatory roles hold significance in understanding aging and age-related diseases, as well as potential therapeutic implications in cancer and other disorders. Further research is warranted to fully elucidate its role in these contexts.