### PELP1 Gene Overview

**Gene Symbol:** PELP1  
**NCBI Gene ID:** 9152  
**UniProt Accession:** Q9Y6V9

The PELP1 (proline, glutamic acid, and leucine-rich protein 1) gene encodes a multifunctional protein that interacts with various nuclear hormone receptors, particularly estrogen receptors (ERs). It acts as a transcriptional coactivator and plays crucial roles in hormone signaling, cancer progression, and cell cycle regulation.

#### 1. Associated Genes

PELP1 interacts with several other genes and proteins, including but not limited to:
- **RB1**: Retinoblastoma 1, involved in cell cycle regulation.
- **SRC**: Proto-oncogene that encodes a protein involved in signaling processes.
- **PIK3CA**: Phosphoinositide-3-kinase catalytic subunit alpha, often implicated in cancer signaling.
- **EGFR**: Epidermal Growth Factor Receptor, involved in cell growth and division.
- **STAT3**: Signal Transducer and Activator of Transcription 3, involved in cell growth and apoptosis.

#### 2. Aging and Age-related Diseases

While direct studies specifically linking PELP1 to aging or age-related diseases are limited, its involvement in cancer progression signifies a potential relationship. Given PELP1's role in signaling pathways that are often disrupted in various cancers, including breast cancer, it may indirectly affect age-related increases in cancer risk. Additionally, its interactions with signaling pathways related to growth factors may influence age-related changes in cellular proliferation and tissue repair mechanisms.

#### 3. Drug Interactions

Specific drugs targeting pathways in which PELP1 is involved include:
- **Tamoxifen**: A selective estrogen receptor modulator used in breast cancer treatment. It targets estrogen receptor pathways, where PELP1 is a key player.
- **Aromatase Inhibitors** (e.g., Anastrozole, Letrozole): These inhibit estrogen production and influence estrogen receptor-dependent pathways.
  
Other drug classes that may indirectly interact with PELP1 due to its roles in signaling are:
- **PI3K inhibitors**: Since PELP1 interacts with PI3K, inhibitors of this pathway may affect PELP1's activity or function.
- **SRC inhibitors**: Such as Dasatinib, which targets the SRC family of kinases involved in cancer pathways.

#### 4. Pathways and Biological Processes

PELP1 is involved in several significant pathways and biological processes, including:

- **Estrogen signaling pathways**: Mediating estrogen receptor (ER) activity, influencing gene transcription in response to estrogen.
- **Cell cycle regulation**: Interacting with RB1 to facilitate cell cycle progression, particularly in the context of estrogen signaling.
- **RNA processing**: Component of the PELP1 complex involved in the nucleolar maturation of rRNA and pre-ribosomal complexes.
- **Cell migration and metastasis**: Modulating cytoskeletal changes in response to estrogen, which may facilitate cancer cell migration.
- **Transcription regulation**: Acting as a coactivator and corepressor of various transcription factors and hormone receptors.

Overall, PELP1 serves pivotal roles in gene expression regulation in hormone signaling, cancer development, and potential implications in aging-related cellular functions. Further research may elucidate its broader impacts on aging and age-related diseases.