### Overview of RAB11FIP3 Gene

**Gene Symbol:** RAB11FIP3  
**Chromosomal Location:** Human chromosome 11 (11q13.2)

RAB11FIP3 (RAB11 Family Interacting Protein 3) is involved in various cellular processes, primarily related to membrane trafficking and cytokinesis, as well as the interplay of cytoskeletal dynamics.

### Associated Genes

While specific gene interactions frequently depend on the context (such as tissue type or cellular state), RAB11FIP3 has been linked or associated with several other genes:

1. **RAB11A** - A member of the RAB family of proteins involved in vesicular transport, which RAB11FIP3 collaborates with in recycling endosomal pathways.
2. **DYNC1H1** - The dynein heavy chain gene, which is involved in the function of dynein motor complexes that RAB11FIP3 links to various cargoes.
3. **DCTN1** - The dynamitin gene, a part of the dynactin complex that is linked to dynein and endosomal transport.
4. **ACTB** - The actin beta gene, as RAB11FIP3 is suggested to play a role in actin cytoskeleton regulation.
5. **PARD3** - Linked to cell polarity and signaling, which may interact with RAB11FIP3 functions in cytokinesis.

### Aging and Age-Related Diseases

While specific studies addressing RAB11FIP3 in the context of aging or age-related diseases are relatively limited, there are potential links:

- **Cancer:** As indicated, RAB11FIP3 may play a role in breast cancer cell motility. Altered endocytic trafficking and cytoskeletal dynamics are commonly observed in cancer cells, which can be linked to age-related changes in tissue architecture and cellular integrity.
- **Neurodegeneration:** Impairments in cellular trafficking and cytoskeletal interactions are hallmarks of neurodegenerative diseases, which often have aging as a major risk factor. Though RAB11FIP3 is not directly implicated in specific neurodegenerative conditions, its role in vesicular transport could influence age-related neurodegenerative processes.

### Drug Interactions

As of now, specific drug interactions or drug classes directly targeting RAB11FIP3 have not been well-documented. However, potential indirect interactions may arise from compounds affecting microtubule dynamics or endocytosis pathways, such as:

1. **Microtubule Stabilizers/Disruptors** - Drugs that can influence dynein behavior and, by extension, RAB11FIP3 function.
2. **Cytoskeletal-acting agents** - Agents influencing actin polymerization may indirectly affect RAB11FIP3-mediated processes.

### Pathways and Biological Processes

RAB11FIP3 is involved in several critical pathways and biological processes:

1. **Endocytosis** - Participates in the regulation of endocytosis, particularly in the recycling of membrane proteins through the endosomal pathway.
2. **Cytokinesis** - Essential during late cytokinesis for membrane delivery at the cleavage furrow; promotes structural integrity of the endosomal recycling compartment during interphase.
3. **Cell Motility** - May play a role in the modulation of cell motility through actin cytoskeleton regulation, important in cancer metastasis.
4. **Transport and Trafficking** - Functions as a crucial adaptor linking dynein to various cellular cargo for efficient microtubule-based transport.

In conclusion, RAB11FIP3 is a multifunctional protein involved in a variety of cellular processes essential for maintaining cellular function, particularly in membrane trafficking, cytoskeletal dynamics, and cytokinesis. Further research is likely to elucidate more specific interactions, potential roles in aging, and therapeutic targets involving RAB11FIP3.