### LINC00858 Gene Summary

**Gene Symbol:** LINC00858

**Description:**
LINC00858 is a long intergenic non-coding RNA (lincRNA) that plays roles in various regulatory processes at the genomic level. Being a non-coding RNA, it primarily functions in the modulation of gene expression and can be involved in cellular processes such as transcription regulation and chromatin remodeling.

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### Associated Genes
While the summaries may not provide specific genes associated with LINC00858, non-coding RNAs often interact with protein-coding genes to regulate their expression. The gene may be implicated in pathways involving key regulatory proteins. Some known interactions could include:

- **Genes in the MDM2 and TP53 pathways:** LINC00858 has been linked to cellular responses involving these important regulators of the cell cycle and apoptosis.
- **Cancer-associated genes:** Non-coding RNAs like LINC00858 can interact with tumor suppressor genes and oncogenes indirectly through regulatory networks, possibly involving KRAS or MYC.

Please note that specific associations may also emerge from more recent studies, and accessing databases like GeneCards or functional genomics publications could provide more insights.

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### Aging and Age-related Disease Association
Research indicates that LINC00858 may be implicated in various age-related diseases, including:

- **Cancer:** There is growing evidence that lncRNAs, including LINC00858, influence tumor progression and may be dysregulated in different types of cancers. The expression levels of LINC00858 can correlate with disease state and prognosis in some cancer types.
- **Neurodegenerative Diseases:** Non-coding RNAs play important roles in neuronal function and maintenance; disruptions in their levels or functions are sometimes observed in conditions like Alzheimer's disease.

Investigation into the specific effects of LINC00858 on aging or age-related diseases is ongoing, and its role in cellular senescence or regulatory networks related to lifespan extension should be examined further.

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### Drug Interactions
As of October 2023, specific drug interactions with the LINC00858 gene are not well-documented. However, because lncRNAs are often involved in regulatory pathways, pharmaceutical agents that target pathways relevant to cancer growth, inflammation, or neurodegenerative processes might indirectly interact with the functions of LINC00858.

Common drug classes that may connect through pathways influenced by LINC00858 includes:
- **Chemotherapeutic agents**: Since lncRNAs can affect tumor biology, drugs affecting cancer pathways may interact indirectly through their modulation of LINC00858 expression.
- **Antidepressants**: Some studies suggest that lncRNAs may play roles in mood regulation and pathophysiology of mood disorders.

Specific research will be necessary to confirm any direct drug interactions involving LINC00858 or the impact of drugs on its expression.

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### Biological Processes and Pathways

LINC00858 is involved in several biological processes, including but not limited to:

- **Gene Expression Regulation:** Long non-coding RNAs commonly act as transcriptional regulators by interacting with transcription factors or the transcription machinery.
- **Epigenetic Regulation:** LINC00858 might be involved in shaping chromatin architecture, influencing which genes are active or silenced in a context-dependent manner.
- **Cell Proliferation and Apoptosis:** Its expression levels might modulate the pathways regulating cell survival and death, particularly under stress conditions.

Recent studies have suggested a role in specific pathways linked to cancer biology (such as the PI3K-Akt signaling pathway) or cellular stress responses, but its exact functions are still being elucidated.

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In conclusion, while still an area of active research, LINC00858 appears to hold significance in cellular regulation with potential implications in aging, cancer biology, and therapeutic targets. Further studies will help clarify the spectrum of its functional genome interactions and clinical relevance.