### FENDRR Gene Overview

**Gene Symbol**: FENDRR (FENDRR - Fetal Expression of Non-coding RNA)

**Description**:
The FENDRR gene produces a long non-coding RNA (lncRNA) that is transcribed bidirectionally alongside the FOXF1 gene, which is located on the opposite strand. This gene is crucial for various biological processes, including normal development, particularly in the context of cardiac and body wall formation in models such as mice. 

FENDRR is associated with regulating gene expression through its interaction with polycomb repressive complex 2 (PRC2) and other similar complexes, thereby influencing the methylation of target gene promoters and potentially reducing their expression levels.

### 1. Associated Genes

While the FENDRR gene interacts closely with FOXF1, studies suggest links with other genes, especially those involved in developmental processes. These may include:

- **Hox genes**: Given their role in developmental processes, especially those regulated by the polycomb complex.
- **Cdx family genes**: Associated with body plan development.
- **Various oncogenes and tumor suppressor genes**: In relation to its involvement in cancer progression, especially gastric cancer.

### 2. Aging and Age-Related Diseases

While direct associations between FENDRR and aging or specific age-related diseases are less established compared to other genes, there are a few implications derived from its functions:

- **Cancer Progression**: Given that FENDRR is suggested to play a role in gastric cancer, this association may extend to age-related cancer susceptibility, where lncRNAs may influence tumor microenvironments and cellular senescence.
- **Developmental and Cardiovascular Implications**: Inverse regulation of target genes by FENDRR may have repercussions in age-related heart diseases, where proper gene expression is vital for maintaining cardiac function and overall homeostasis.

### 3. Drug Interactions

There are currently no specific drugs directly targeting FENDRR indicated in databases. However, the pathways and complexes (e.g., PRC2) associated with FENDRR could be influenced by:

- **Histone deacetylase inhibitors (HDACi)**: Given their role in altering chromatin structure, they may indirectly affect the expression of FENDRR and its target genes involved in the repression of cancer.
- **Drugs targeting the methylation pathways**: Such as those used in cancer treatments, could potentially modulate FENDRR-related pathways.

### 4. Pathways and Biological Processes

FENDRR is involved in several key biological processes and pathways, including:

- **Cardiogenesis**: Essential for normal heart development.
- **Regulation of Gene Expression**: Through binding to chromatin-modifying complexes influencing gene methylation and expression.
- **Developmental Processes**: Plays a role in mesodermal and epithelial development, potentially affecting tissue morphogenesis.
- **Cancer Pathways**: Implicated in the regulation of pathways associated with tumorigenesis, particularly in gastric cancers.

Overall, FENDRR plays a multifaceted role, particularly in regulating developmental processes and possibly influencing cancer biology and age-related health outcomes through its interactions with chromatin remodeling complexes and target gene regulation. Further research continues to uncover its full biological significance.