### CABLES1 Gene Overview

**Gene Symbol:** CABLES1  
**Function:** CABLES1 encodes a cyclin-dependent kinase (CDK) binding protein that plays a critical role in regulating the cell cycle. Through its interactions with CDKs, CABLES1 modulates various cellular processes, including stress response, neuronal development, and apoptotic signaling.

### 1. Associated Genes
While the summaries provided do not list specific associated genes, CABLES1 has been implicated in pathways and interactions involving several key regulatory proteins. Some related genes may include:
- **CDK2:** CABLES1 is known to negatively regulate CDK2 activity.
- **CDK5:** It enhances the activity of CDK5, particularly in neurons.
- **p53/p73:** Involved in cell death regulation.
- **ABL1:** A non-receptor tyrosine kinase that activates CDK5 through phosphorylation.
- **WEE1:** A kinase that regulates CDK2 activity, negatively influenced by CABLES1.

### 2. Aging and Age-Related Diseases
While specific studies focusing directly on CABLES1 in the context of aging are limited, its involvement in cell cycle regulation and apoptotic processes suggest potential implications in:
- **Cellular Senescence:** Regulation of the cell cycle with age may link to senescence pathways.
- **Neurodegenerative Diseases:** CABLES1’s involvement in neuronal development and signaling suggests its potential role in age-related neurodegeneration.
- **Cancer:** Altered expression of CABLES1 transcripts in cancers, especially colorectal cancer, may reflect its significance in age-related disease susceptibility, as cancer risk increases with age.

### 3. Drug Interactions
Currently, there are no well-documented specific drugs directly targeting CABLES1. However, as CABLES1 intersects with key pathways involving CDKs, potential interactions could arise through drugs that affect:
- **CDK Inhibitors:** These include drugs like roniciclib, flavopiridol, and others that may indirectly influence pathways involving CABLES1.
- **Tyrosine Kinase Inhibitors:** Drugs that inhibit ABL1 or related kinases may provide relevant pharmacological contexts since CABLES1 mediates CDK5 activation through ABL1.

### 4. Pathways and Biological Processes
CABLES1 is involved in several important biological processes and pathways:
- **Cell Cycle Regulation:** CABLES1 plays a role in the regulation of the cell cycle at multiple checkpoints, especially through its influence on CDK activity.
- **Apoptosis:** CABLES1 interacts with p53/p73 pathways, thereby regulating programmed cell death.
- **Neuronal Development:** Positive modulation of neuronal outgrowth underscores its role in brain development and function.
- **Phosphorylation Pathways:** It interacts with non-receptor tyrosine kinases impacting the phosphorylation states of various proteins involved in cell cycle progression.

In summary, CABLES1 is a multi-functional gene involved in the regulation of cell cycle and apoptosis, with implications in cancer biology and neuronal development, and potential relevance to aging and neurodegenerative diseases. Further studies might provide clearer insights into its mechanisms of action and associated therapeutic targeting strategies.