### RNA5SP144 Gene Overview:

**Gene Symbol**: RNA5SP144

**Description**: RNA5SP144 is a non-coding RNA gene, specifically a member of the small nucleolar RNA (snoRNA) family. snoRNAs are involved in the modification and processing of ribosomal RNA (rRNA) and play key roles in the biogenesis of ribosomes.

### 1. Associated Genes:
While RNA5SP144 primarily serves as a snoRNA, it is often associated with other genes involved in ribosome biogenesis and rRNA modification. Specific gene associations may not be extensively documented in standard databases, but generally, snoRNAs like RNA5SP144 often work in concert with:

- Other snoRNA genes (e.g., RNA5SP1, H/ACA snoRNAs)
- Ribosomal protein genes (e.g., RPL26, RPS7)
- Genes involved in RNA processing machinery (e.g., DKC1, NOP58)

### 2. Aging and Age-Related Diseases:
Research related to small nucleolar RNAs, including RNA5SP144, is ongoing. However, specific studies targeting RNA5SP144 in the context of aging or age-related diseases are limited. Generally, alterations in the expression of snoRNAs can be linked to various age-related conditions as they may influence ribosome biogenesis and protein synthesis, impacting cellular function. Notable findings include:

- Dysregulation of snoRNAs has been observed in various cancers, which are often more prevalent in aged populations.
- SnoRNAs play roles in cellular homeostasis and stress responses, which can be altered by aging.

### 3. Drug Interactions:
Currently, there is limited information available about specific drugs or drug classes that directly interact with RNA5SP144. However, since snoRNAs are involved in ribosome biogenesis:

- Some chemotherapeutic agents that target ribosome synthesis pathways or RNA processing may indirectly affect snoRNA expression or function.
- Interfering RNA (e.g., siRNAs) designed to modify gene expression could theoretically target snoRNAs, but specific clinical applications would need further research validation.

### 4. Pathways and Biological Processes:
RNA5SP144 is primarily involved in several critical pathways related to ribosomal RNA processing and modification:

- **rRNA Methylation**: As a snoRNA, RNA5SP144 is involved in the 2'-O-methylation of ribosomal RNA, which is crucial for ribosome stability and function.
- **Ribosome Biogenesis**: This gene plays a role in the formation of ribosomes, an essential process for cellular growth and protein synthesis.
- **Small Nucleolar RNA Function**: Participation in the post-transcriptional modification of rRNA and potentially in mRNA splicing.

### Conclusion:
RNA5SP144 is a non-coding RNA primarily associated with the biogenesis and modification of ribosomal RNA. Ongoing research may elucidate its specific roles in aging and disease as well as potential therapeutic applications or drug interactions. While its direct associations with diseases and drug interactions are limited, snoRNA activity is critical in maintaining cellular function, particularly in the context of ribosome production and stability.