### RNU6-165P Gene Overview

**Gene Symbol:** RNU6-165P

**Description:** RNU6-165P is a gene that encodes a small nuclear RNA (snRNA), which plays a role in RNA splicing, specifically functioning as a component of the spliceosome. It is a part of the U6 RNA family, which is critical in the catalysis and regulation of the splicing process of pre-mRNA. 

### 1. Associated Genes

While RNU6-165P is primarily recognized for its role in splicing as part of the machinery that processes mRNA, direct associations with other specific genes are not usually highlighted in databases. However, generally, snRNAs like RNU6-165P are involved with:

- **SNRNPs (small nuclear ribonucleoproteins)** such as SNRNP70, SNRNP160, which form complexes crucial for the splicing process.
- **RNA processing genes** could also be indirectly related, as a dysregulation in snRNAs can lead to splicing abnormalities and potentially affect multiple transcripts.

### 2. Association with Aging or Age-Related Diseases

While there may not be direct research tying RNU6-165P itself specifically to aging processes or age-related diseases, the class of small nuclear RNAs, and particularly the U6 family, has been implicated in:

- **Altered splicing** associated with age-related diseases like Alzheimer’s and other neurodegenerative disorders. Abnormal splicing mechanisms tend to become more prevalent with age.
- **Cancer**: Dysregulation of snRNAs, including U6, can lead to splice variants that contribute to tumor progression.

Research exploring the effects of splicing in aging and diseases is an active area, indicating that alterations in genes like RNU6-165P may hold relevance for these conditions given their involvement in fundamental cellular processes.

### 3. Drug Interactions

Drugs directly targeting non-coding RNAs like RNU6-165P are not well characterized. However, there are therapeutic strategies and classes of drugs that target RNA splicing or RNA regulatory mechanisms, which may indirectly impact its functions. Potential classes involve:

- **Antisense oligonucleotides (ASOs)**: These can manipulate RNA splicing, although the specificity towards RNU6-165P would need to be validated.
- **Chemotherapeutics**: Drugs like spliceostatin A and others that affect spliceosome function might indirectly impact genes in this class.

### 4. Pathways and Biological Processes

RNU6-165P is primarily involved in:

- **mRNA Splicing:** As part of the spliceosome complex, it facilitates the removal of introns and the joining of exons in precursor mRNA.
- **RNA Processing:** It plays a significant part in post-transcriptional modifications and the maturation of RNA molecules which is crucial for gene expression regulation.
- **Regulation of Gene Expression:** The accurate splicing of premRNA is essential for producing the correct protein isoforms necessary for cell function, impacting various biological pathways.

In summary, RNU6-165P plays a critical role in mRNA splicing and RNA processing-related pathways. While associations with specific aging-related mechanisms and drug interactions are not extensively established, it is situated in a broader context where splicing abnormalities can contribute to age-related diseases. Further research may elucidate more specific connections to genes and pathways as the field evolves.