### ING4 Gene Overview

**Gene Symbol**: ING4  
**Location & Function**: The ING4 gene encodes for a tumor suppressor protein that is part of the ING (Inhibitor of Growth) family, which are known to be involved in various cellular processes, including cell growth, apoptosis, and transcriptional regulation. The protein contains a PHD-finger domain, facilitating its role in chromatin remodeling and transcriptional regulation.

### 1. Associated Genes

While the NCBI and UniProt summaries mention interactions with **TP53** (also known as p53) and **EP300** (a histone acetyl transferase), ING4 is also associated with genes involved in various signaling pathways, including:

- **MYC**: An oncogene whose activation can lead to cell proliferation.
- **HIF1A**: The hypoxia-inducible factor that ING4 may inhibit.
- **RELA/NFKB3**: Part of the NF-kB signaling pathways, associated with inflammation and cancer.
- **EGLN1**: Enzyme associated with hypoxia regulation that ING4 can interact with to modulate HIF activity.

### 2. Aging and Age-Related Diseases

ING4 has been implicated in the processes of cellular senescence and aging. Its inhibition of tumor progression and involvement in apoptosis suggests a potential protective role against age-related diseases, especially cancer. Notably:

- **Tumor Suppression**: As a tumor suppressor, ING4 may play a crucial role in preventing age-related malignancies by regulating cell growth and modulating signaling pathways.
- **Brain Tumors**: Since it can suppress angiogenesis in brain tumors, alterations in ING4 expression may influence the development of brain tumor pathologies in aging populations.

Although direct associations with specific age-related diseases outside cancer may not be well-established, its role in cellular processes pertinent to aging itself (e.g., apoptosis, chromatin remodeling) is noteworthy.

### 3. Drug or Drug Classes that Interact

While there are no specific drugs listed that directly target or interact with ING4, research into gene therapy and molecular interventions aims at modulating the pathways involving ING4 could lead to:

- **Histone Deacetylase (HDAC) Inhibitors**: Given ING4's role in histone acetylation, drugs in this class could potentially influence its regulatory function on transcription and chromatin state.

- **Targeted Cancer Therapies**: As ING4 plays a role in tumor suppression, drugs aimed at reinstating its function, or strategies to ensure proper expression of ING4, are of interest in cancer therapeutics.

### 4. Pathways and Biological Processes

ING4 is involved in several key biological pathways and processes:

- **Chromatin Remodeling**: Through its interactions with chromatin-modifying complexes, ING4 plays a role in modulating chromatin architecture.
  
- **TP53 Signaling Pathway**: ING4 is implicated in TP53-dependent transcriptional regulation, affecting cell cycle control and apoptosis.
  
- **Angiogenesis Regulation**: The ability of ING4 to repress genes associated with angiogenesis, particularly in the context of tumors, suggests its role in this biological process.
  
- **Response to Hypoxia**: By modulating HIF activity and regulating gene expression during low oxygen conditions, ING4 contributes to cellular adaptations to hypoxic stress.

- **Cell Proliferation and Apoptosis**: The gene regulates processes that can inhibit uncontrolled growth and promote programmed cell death, critical for maintaining tissue homeostasis.

### Conclusion

ING4 is a multifaceted gene with significant implications in tumor biology, aging, and potentially therapeutic interventions. Its diverse interactions and roles in cellular processes make it a pertinent subject of study for understanding cancer precursors, age-related pathologies, and targeting treatment modalities.