### FKBP11 Gene Overview

**Gene Symbol:** FKBP11  
**Description:** FKBP11 (FK506 Binding Protein 11) is a gene that encodes a member of the FKBP family of immunophilins, which are peptidyl-prolyl cis-trans isomerases (PPIases). These proteins play a crucial role in protein folding and the regulation of various cellular processes by modulating the conformation of target proteins.

### 1. Associated Genes
FKBP11 is often studied in relation to its interactions with other genes that encode proteins involved in similar pathways or processes. While specific interacting genes may not always be universally acknowledged, FKBP11 can be associated with genes that encode proteins related to:

- FKBP family members (e.g., FKBP1A, FKBP12)
- Other immunophilins and chaperones (e.g., HSP90AA1)
- Genes involved in signaling pathways such as those influenced by immune modulators and steroid hormone receptors.

### 2. Aging and Age-Related Diseases
Research has hinted at roles for FKBP family proteins in aging processes and associated diseases, although specific studies on FKBP11 itself might be limited. Some general points include:

- FKBP proteins have been implicated in the cellular response to stress and maintenance of proteostasis, both of which are critical as organisms age.
- Dysregulation of PPIases, including FKBP11, has been associated with neurodegenerative diseases and conditions characterized by protein misfolding.
- SENP and FKBP interactions have been linked to cellular senescence and aging, though more research is needed to clarify FKBP11's direct role in these processes.

### 3. Drug Interactions

FKBP11 is implicated in the action of several immunosuppressive drugs, particularly those that bind to FKBP proteins, including:

- **Tacrolimus (FK506)**: An immunosuppressant often used in organ transplant recipients, targeting FKBP proteins to inhibit calcineurin activity, which affects T-cell activation.
- **Rapamycin**: While it primarily binds to FKBP12, interactions and pathways involving FKBP11 may also play roles in the overall effects of rapamycin, particularly in terms of mTOR signaling.

### 4. Biological Pathways and Processes

FKBP11 is involved in various biological processes, including:

- **Protein Folding**: As a PPIase, FKBP11 accelerates protein folding and assists in refolding damaged proteins.
- **Cell Signal Transduction**: Interacts with several signaling pathways including those modulating immune response and hormone signaling.
- **Response to Unfolded Proteins**: Plays a potential role in the cellular response to stress, particularly in the context of disturbed proteostasis.

### Summary

FKBP11 is a significant player in protein folding and cellular homeostasis, with potential implications in aging, immune modulation, and interactions with important pharmacological agents. Its exact roles in various diseases and conditions continue to be an area of active research, underscoring the importance of FKBP proteins in both basic biology and clinical contexts.