### SPECC1L Gene Overview

**Gene Symbol:** SPECC1L  
**Chromosomal Location:** 20q11.23  
**Protein Function:** The SPECC1L gene encodes a protein that contains coiled-coil domains and is involved in cytoskeletal organization, particularly during processes such as cytokinesis and facial morphogenesis. Given its role in actin-cytoskeletal reorganization, it is crucial for cell adhesion and migration.

### 1. Associated Genes
Beyond those specified in the summaries, SPECC1L has been linked to other genes through various biological pathways and structural associations, including:
- **ACTB (Beta-actin):** A key cytoskeletal protein.
- **MYH10 (Myosin Heavy Chain 10):** Involved in cellular motility.
- **CDH1 (E-cadherin):** Plays a critical role in cell adhesion.
- **ARHGAP (Rho GTPase-activating protein):** Modulates Rho proteins that regulate cytoskeleton dynamics.

### 2. Aging and Age-related Diseases
Research suggests that dysregulation of cytoskeletal dynamics, in which SPECC1L is involved, may contribute to various age-related diseases, including:
- **Cancer:** Altered cell adhesion and migration can lead to metastasis.
- **Neurodegenerative Diseases:** Changes in cell morphology and intracellular transport related to cytoskeletal proteins could impact neurodegeneration.
- **Cardiovascular Diseases:** Alterations in cell adhesion and signaling pathways could impact vascular integrity and contribute to age-associated heart diseases.

The specific effects of SPECC1L in aging-related processes are not fully characterized in the literature, warranting further investigation.

### 3. Drug Interactions
While there are no known specific drugs or drug classes explicitly highlighted in relation to direct interactions with the SPECC1L gene, drugs targeting pathways related to cytoskeletal dynamics, actin polymerization agents (such as cytochalasins), or microtubule-stabilizing agents (like taxanes) may indirectly influence its function via effects on cellular architecture:
- **Cytoskeletal Agents:** These may affect the organization and dynamics of the cytoskeleton, hence indirectly modulating the activities of SPECC1L.

### 4. Pathways and Biological Processes
SPECC1L is involved in various biological processes:
- **Cytokinesis:** Essential for cell division.
- **Actin Cytoskeleton Organization:** Influences shape and motility of cells.
- **Microtubule Stabilization:** Impacts cell division and stability of cellular structures.
- **Facial Morphogenesis:** Critical role in the proper development of facial structures.
- **Cell Migration and Adhesion:** Essential for tissue integrity and repair.

In summary, the SPECC1L gene plays a significant role in cellular organization and dynamics, with implications in developmental processes such as facial morphogenesis and potential associations with aging-related conditions. Further research might elucidate more specific roles and therapeutic targets related to this gene.