### RNA5SP461 Gene Overview

The **RNA5SP461** gene is known to encode a small nucleolar RNA (snoRNA) that primarily functions in the biogenesis and modification of ribosomal RNA (rRNA). snoRNAs often play integral roles in the chemical modification of rRNAs, particularly during ribosome maturation.

### 1. Associated Genes

While specific associations might not frequently be mentioned in standard gene summaries for small RNAs like RNA5SP461, snoRNAs often function in related pathways with several genes involved in ribosome biogenesis. Other snoRNAs and genes coding for ribosomal proteins would typically be involved in similar processes and might be co-regulated. Here are a few classes of genes that might show association:
- **Ribosome biogenesis genes:** These could include various RFC (Ribosome Formation Component) genes.
- **Proteins related to RNA modification:** Such as **NOP56, NOP58**, and other proteins involved in the assembly of the spliceosomal and ribosomal complexes.

### 2. Aging and Age-Related Diseases

Current literature does not indicate a direct connection between RNA5SP461 and aging or age-related diseases. However, snoRNAs in general have been implicated in various cellular processes, and altered snoRNA expression can influence the cellular response to stress and proliferation, which may contribute to age-related phenomena. Alterations in snoRNA expression profiles have also been observed in some cancers, which can be indirectly linked to aging processes.

### 3. Drug or Drug Classes

As of the most recent updates, there are typically no direct drugs or drug classes that interact specifically with small nucleolar RNAs like RNA5SP461. However, since snoRNAs are implicated in ribosome biogenesis, drugs that affect ribosomal function (such as certain antibiotics that target ribosomal subunits) can indirectly affect the processes involving snoRNAs. Research into small RNA interactions with therapeutic agents is ongoing.

### 4. Pathways and Biological Processes

RNA5SP461 is involved in the following biological processes and pathways:

- **Ribosome Biogenesis:** It is involved in the maturation and modification of rRNA, influencing how ribosomes are assembled and function.
- **RNA Processing and Modification:** This includes methylation of rRNA, which is critical for the structural integrity and precision of ribosomal assembly.
- **Cell Cycle Regulation:** While not directly implicated, snoRNA modifications can indirectly affect protein synthesis during different phases of the cell cycle, potentially influencing cellular growth and proliferation.

### Conclusion

RNA5SP461 is a small nucleolar RNA involved primarily in ribosomal RNA biogenesis and modification. Its association with other genes, direct interactions with pharmacological agents, and implications in aging remain areas of research interest. Further studies are needed to elucidate its comprehensive role in cellular processes, particularly concerning aging and disease.