### PSPC1 Gene Overview

**Gene Symbol**: PSPC1  
**Location**: Chromosome 13  
**Function**: Encodes a nucleolar protein that is a component of paraspeckles, which are RNA-protein structures involved in regulating gene expression and maintaining nuclear organization.

### 1. Associated Genes

While the primary gene interactions highlighted are with NONO and SFPQ, other genes that have been implicated in association with PSPC1 include:

- **NEAT1**: A long non-coding RNA essential for the formation of paraspeckles.
- **CNOT6**: Involved in the regulation of messenger RNA stability.
- **TERF2IP**: Associated with telomere maintenance and might interact indirectly through RNA processing.
- **CLOCK**: Interacts with PSPC1 in the regulation of circadian rhythms, though it itself may not be directly linked to paraspeckle structure.
- **BMAL1**: Partner of CLOCK in the circadian rhythm regulation which PSPC1 may affect.

### 2. Aging and Age-Related Diseases

- **Cellular Senescence**: PSPC1 has been suggested to play a role in the cellular response to stress which is associated with senescence. Altered expression of PSPC1 could affect cellular mechanisms that influence aging.
  
- **Neurodegenerative Diseases**: Some studies indicate that disruptions in paraspeckle function, including proteins like PSPC1, can contribute to the pathogenesis of disorders such as Alzheimer’s disease.

- **Cancer**: Given its role in transcriptional regulation, PSPC1 may be involved in tumorigenesis. Abnormal levels of PSPC1 and its interacting proteins can influence cancer cell proliferation and survival, linking it to age-related cancers.

### 3. Drug Interactions

Currently, there are limited direct interactions of specific drugs with PSPC1; however, it has been implicated in processes that could be influenced indirectly by therapeutic agents:

- **Antiviral Drugs**: Due to its role in the innate immune response and viral interactions, PSPC1 may be affected by antiviral therapies, though specific drugs have not been firmly established.

- **Hormonal Therapies**: As it is involved in androgen receptor-mediated transcription, drugs interacting with androgen signaling (like anti-androgens) may have a secondary influence on PSPC1 activity.

### 4. Pathways and Biological Processes

PSPC1 is involved in several key biological processes and cellular pathways:

- **RNA Processing**: It plays a vital role in mRNA splicing, retaining certain RNA transcripts in the nucleus.

- **Gene Expression Regulation**: Influences gene transcription activity, particularly through interactions with NONO and SFPQ.

- **Circadian Clock Regulation**: Implicated in circadian rhythms, regulating the expression and activity of CLOCK and BMAL1.

- **Innate Immune Signaling**: Participates in the cellular response to viral infections by assembling into the HDP-RNP complex, which is important for activating the cGAS-STING pathway.

- **Nuclear Body Formation**: Essential for the formation and maintenance of paraspeckles within the nucleus, which are important for the regulation and storage of specific RNA molecules.

### Summary

The PSPC1 gene encodes a nucleolar protein integral to subnuclear structure, RNA processing, transcriptional regulation, and immune response. Its association with various cellular pathways indicates its potential importance in health, aging, and disease contexts, especially related to cancer and neurodegeneration. Further understanding of PSPC1 could provide insights into therapeutic targeting and biomarker development for age-related diseases.