The PPP1R3B gene encodes a regulatory protein that plays a crucial role in glycogen metabolism by acting as a glycogen-targeting subunit for the serine/threonine phosphatase protein phosphatase-1 (PP1). This protein is particularly important in liver and skeletal muscle tissues. Here are the additional details requested:

### 1. Associated Genes:
- **PYGL (glycogen phosphorylase, liver)**: PPP1R3B acts to inhibit the activity of PYGL, which is involved in glycogen breakdown.
- **GYS1 (glycogen synthase 1)**: Involved in glycogen synthesis, its activity is enhanced by the action of the PPP1R3B regulatory protein.
- **GYS2 (glycogen synthase 2)**: Similar to GYS1, it is involved in glycogen synthesis in different tissues.
- **G6PC (glucose-6-phosphatase, catalytic subunit)**: Involved in glucose metabolism and may relate to the regulation of glycogen metabolism.
- **AKT1 (AKT serine/threonine kinase 1)**: Involved in insulin signaling, it may have downstream effects related to glycogen synthesis mediated by PPP1R3B.

### 2. Aging and Age-Related Diseases:
- Research indicates that abnormal glycogen metabolism can be linked to insulin resistance, which is central to type 2 diabetes and is often associated with aging.
- There is a potential connection of PPP1R3B with metabolic syndrome, a condition characterized by increased risk factors for cardiovascular diseases and type 2 diabetes which can occur with aging.
- Variants or dysregulation of PPP1R3B may be implicated in the development of type 2 diabetes, which has a clear correlation with age and the aging population's increasing prevalence of the disease.

### 3. Drug Interactions:
- There are no specific drugs mentioned that directly target PPP1R3B; however, drugs that affect insulin signaling (e.g., Metformin) could influence the pathways in which PPP1R3B is involved.
- Additionally, pharmacological agents that target pathways of carbohydrate metabolism (like glucagon-like peptide-1 (GLP-1) agonists) may indirectly affect the expression or function of PPP1R3B due to its roles in glycogen synthesis.

### 4. Pathways and Biological Processes:
- **Glycogen Metabolism**: PPP1R3B is integral in the glycogen synthesis pathway by regulating the dephosphorylation processes of glycogen synthase and glycogen phosphorylase.
- **Insulin Signaling Pathway**: It plays a role in the response to insulin, particularly in the liver, modulating responses that increase glycogen synthesis.
- **AMPK Signaling**: Although not direct, there is an indirect connection as AMPK is activated under low energy conditions and could influence glycogen metabolism pathways in which PPP1R3B is a component.
- **Cellular Response to Insulin**: By modulating PP1 activity, PPP1R3B helps translate insulin signaling into metabolic responses that promote glycogen storage.

Collectively, PPP1R3B is a key component of glycogen regulation, and its function relates significantly to metabolic health, particularly in the context of aging and diabetes.