### EPCAM-DT Gene Overview

**Gene Symbol:** EPCAM-DT (EPCAM divergent transcript)

The EPCAM-DT gene is associated with the human EPCAM gene (Epithelial Cell Adhesion Molecule) and is often classified as a long non-coding RNA (lncRNA). It is located on chromosome 2, near the EPCAM gene, and is thought to be involved in regulatory functions related to the EPCAM gene and its protein product, which is critical in cell-cell adhesion and has a role in cellular processes such as proliferation and differentiation.

### 1. Associated Genes

EPCAM-DT is primarily associated with the **EPCAM** gene itself. Some studies also suggest possible functional interactions or co-regulation with genes involved in cellular adhesion and the epithelial-to-mesenchymal transition (EMT), such as:

- **CDH1** (Cadherin 1, also known as E-Cadherin)
- **VIM** (Vimentin)
- **SNAI1** (Snai1) or related transcription factors that regulate EMT.

### 2. Aging and Age-Related Diseases

Research on the specific role of the EPCAM-DT gene in aging or age-related diseases is limited. However, given its association with the EPCAM gene, it may have indirect implications in:

- **Cancer:** Aberrant expression of EPCAM has been implicated in tumor progression, especially in colorectal cancer and other epithelial cancers.
- **Stem Cell Function:** EPCAM is a marker for certain stem cells, and changes in its expression could have implications for aging and regenerative processes.
- **Tissue Repair and Homeostasis:** Any dysfunction may contribute to the aging process through impaired cellular adhesion or tissue regeneration.

### 3. Drug Interactions

As of now, no specific drugs or drug classes have been definitively linked to the EPCAM-DT gene alone. However, since EPCAM is often overexpressed in various cancers, drugs targeting the EPCAM protein (e.g., monoclonal antibodies like catumaxomab) may indirectly relate to pathways that involve EPCAM-DT due to its proximity and functional relationship with EPCAM.

### 4. Pathways and Biological Processes

The EPCAM-DT gene is likely involved in several biological processes and pathways, including:

- **Cell Adhesion:** Through its association with EPCAM, which plays a crucial role in maintaining the integrity of epithelial tissues.
- **Cell Proliferation and Differentiation:** The regulation of epithelial cell dynamics.
- **Epithelial-to-Mesenchymal Transition (EMT):** This process can be relevant in development and cancer metastasis.
- **Gene Regulation:** As a non-coding RNA, EPCAM-DT may participate in the regulation of gene expression through various mechanisms, including acting as a molecular sponge for microRNAs or recruiting transcriptional complexes.

### Summary

The EPCAM-DT gene, while less characterized than its protein-coding counterpart EPCAM, is an interesting subject in studies related to cell biology, cancer, and potentially aging. Its relationships with various associated genes, pathways, and its implications in disease warrant further investigation to fully elucidate its biological significance.