### CDC27 Gene Overview

**Gene Symbol:** CDC27  
**Gene Location:** Chromosome 10  
**UniProt ID:** Q9NQC3

**Protein Function:**  
The CDC27 gene encodes a protein that is a critical component of the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase essential for the regulation of the cell cycle. The APC/C mediates the ubiquitination and subsequent degradation of various target proteins, including cyclin B, thereby controlling the transition from metaphase to anaphase in mitosis. The protein features tetratricopeptide repeats (TPR), promoting interactions with other proteins, including various mitotic checkpoint complexes like Mad2, p55CDC, and BUBR1. 

### Additional Information

#### 1. Associated Genes
Though the summaries mention specific interactions, CDC27 is also associated with several other genes, including but not limited to:
- **CDC16**: Another component of the APC complex.
- **CDC20**: Works in concert with the APC for substrate recognition and activation.
- **CCNB1 (Cyclin B1)**: A substrate of the APC/C that is targeted for degradation.
- **TP53 (p53)**: Implicated in regulating CDC27's expression due to the role of p53 in cell cycle control.
- **MAD1 and MAD2**: Components of the spindle assembly checkpoint that interact with CDC27 to ensure proper mitotic progression.

#### 2. Aging and Age-related Diseases
While specific age-related effects of the CDC27 gene are less well-documented, its role in cell cycle regulation implies significance concerning aging and age-related diseases. Dysregulation of the APC/C has been linked to:
- **Cancer**: When the degradation processes fail, it can lead to the accumulation of oncogenic proteins, contributing to tumorigenesis.
- **Cellular Senescence**: Proper function of the APC/C is essential for apoptotic processes and aged cells' ability to enter senescence.
- Potential implications in neurodegenerative diseases, where mitotic dysregulation may contribute to cellular pathology.

#### 3. Drug Interactions
Currently, there are no specific drugs that directly target the CDC27 protein. However, mechanisms that alter APC/C activity might influence how cancer therapies work, particularly those involving:
- **Proteasome Inhibitors**: Such as bortezomib, where the proteolytic regulation associated with APC/C can affect cancer treatment outcomes.
- **Chemotherapy Agents**: These often work by disrupting cell cycle progression, where CDC27 activity plays a role.

#### 4. Pathways and Biological Processes
CDC27 is involved in several key biological pathways, including:
- **Cell Cycle Regulation**: Mediator of G2/M and metaphase/anaphase transitions.
- **Ubiquitin-Proteasome Pathway**: Specifically, involved in the ubiquitination processes that mark proteins for degradation by the proteasome.
- **Mitotic Checkpoint Activation**: Interacting with components that assure proper chromosome alignment and separation during mitosis.
- **Regulation of Cyclins**: Ensures timely ubiquitination of cyclins to regulate progression through the cell cycle.

By understanding these detailed aspects of the CDC27 gene, researchers can better understand its physiological roles, its connections to health and disease, and its potential as a therapeutic target in oncology and other fields.