### RHOG Gene Overview

**Gene Symbol:** RHOG  
**Location:** Human Chromosome 1  
**Gene Type:** Protein-coding  

#### Function:
The RHOG gene encodes a small GTPase from the Rho family that acts as a molecular switch involved in various signal transduction pathways. It cycles between GDP-bound inactive and GTP-bound active states, promoting actin cytoskeletal reorganization and influencing cell shape, motility, and attachment. RHOG is crucial for cytoskeletal dynamics in immune cells, particularly for processes like cell migration, lamellipodium formation, and macropinocytosis.

### Additional Information:

1. **Associated Genes:**
   - **RAC1:** RHOG interacts with Rac1, which is also a Rho family GTPase involved in actin cytoskeletal reorganization.
   - **UNC13D:** This gene is important for the exocytosis of cytotoxic granules and interacts with RHOG in lymphocytes.
   - **Other Rho Family GTPases:** Interactions may extend to other members of the Rho GTPase family, such as RHOA, RHOB, and potentially RHOC, regarding cytoskeletal reorganization and signaling pathways.

2. **Aging and Age-Related Diseases:**
   - While specific direct associations between RHOG and aging are less established, alterations in Rho GTPase signaling, including RHOG, are implicated in aging processes and age-related diseases such as cancer and neurodegenerative disorders. Dysregulation in cell migration and immune function related to RHOG may also contribute to promotion of age-related immune dysfunction or failure of wound healing, further emphasizing the importance of RHOG in maintaining cellular integrity during aging.

3. **Drug Interactions:**
   - Currently, no specific drugs are directly known to target RHOG. However, small molecules that modulate the activity of Rho family GTPases as a class may indirectly influence RHOG activity. Drugs targeting pathways involving Rac1 or the overall cytoskeleton may impact functions mediated by RHOG.
   - **Potential drug classes** include:
     - Rho kinase inhibitors (useful in cardiovascular diseases).
     - Agents that influence cytoskeletal dynamics (e.g., latrunculin, cytochalasins).

4. **Pathways and Biological Processes:**
   - **Actin Cytoskeleton Organization:** RHOG is a critical regulator of actin dynamics, promoting lamellipodia and membrane ruffling.
   - **Cell Migration:** Involved in leukocyte trans-endothelial migration, vital in immune response and inflammation.
   - **Exocytosis:** Plays a role in cytotoxic granule exocytosis, particularly in NK and CD8+ T cells, contributing to immune responses and cell-mediated cytotoxicity.
   - **Immunological Synapse Formation:** Regulates F-actin architecture during T-cell activation and synapse formation.
   - **Macropinocytosis:** Required for the formation of membrane ruffles, aiding in the uptake of extracellular materials.
   - **Phospholipid Binding and Membrane Anchor:** Acts in an activation-dependent manner to anchor proteins to the plasma membrane, influencing multiple cell signaling and communication pathways.

### Summary:
The RHOG gene encodes a small GTPase integral to various cellular processes, particularly in immune cell function and cytoskeletal dynamics. Its role in actin reorganization and cell migration underscores its importance in immune responses and potential implications in age-related diseases. Further investigation into its interactions with drugs and pathways could provide insight into therapeutic targets for conditions involving immune dysfunction and aging.