### VAV3 Gene Overview
**Gene Symbol:** VAV3  
**Gene Family:** VAV gene family  
**Function:** VAV3 is a guanine nucleotide exchange factor (GEF) that activates Rho family GTPases, specifically RhoA, RhoG, and to a lesser extent, Rac1. It plays crucial roles in various cellular processes, including actin cytoskeletal rearrangements, angiogenesis, integrin-mediated signaling, and wound healing.

#### Additional Associated Genes
VAV3 interacts or has been reported to have functional associations with several genes, including but not limited to:

1. **EPHA2** - A receptor that notably recruits VAV3 during angiogenic signaling.
2. **SYK** - A tyrosine kinase that interacts with VAV3 in the context of osteoclast signaling.
3. **RAC1**, **RHOA**, **RHOG** - These are the GTPases that VAV3 preferentially acts upon.
4. **ITGB1** (Integrin beta-1) - Involved in the signaling pathways where VAV3 plays a role.
5. **ITGB2** and **ITGB3** - Integrins involved in macrophage adhesion related to VAV3's function.

#### Aging and Age-Related Diseases
Although there is limited direct information linking VAV3 specifically to aging, its roles in cellular migration, adhesion, and wound healing suggest potential implications in age-related processes such as:
- **Chronic inflammation** - Impaired signaling pathways in aging immune cells may affect VAV3 function.
- **Wound healing** - Age-related decline in wound healing efficiency could be associated with altered VAV3 signaling pathways in macrophages and osteoclasts.
- **Cancer** - Given that VAV3 is involved in cellular migration and transformation, dysregulation could contribute to cancer progression, which is more prevalent in aging populations.

#### Drug Interactions
There are currently no specific drugs or drug classes directly associated with VAV3. However, as a GEF involved in cancer biology, signaling pathways regulated by VAV3 could be potential targets of therapeutic agents. Generally, inhibitors of Rho family GTPases (such as Rac1 and RhoA inhibitors) could indirectly affect VAV3 activity.

#### Pathways and Biological Processes
VAV3 is involved in several key pathways and biological processes, including:

1. **Angiogenesis** - Critical in endothelial cell migration and formation of new blood vessels.
2. **Actin Cytoskeleton Rearrangement** - Essential for various cellular movements including adhesion and migration.
3. **Integrin Signaling** - Influences processes such as cell adhesion, migration, and cytoskeletal organization.
4. **Wound Healing** - Involved in macrophage phagocytosis and inflammation resolution.
5. **Immune Response** - Plays a role in macrophage activation and cellular adhesion.

### Summary
VAV3 is an essential player in cellular signaling with implications in diverse biological processes, making it a significant focus of research in the context of cancer, wound healing, and potentially aging-related changes. Further studies may elucidate its direct roles and therapeutic targets for age-related diseases.