The **MKNK1-AS1** gene, also known as a long non-coding RNA, is an important regulatory element within the human genome. It is associated with various biological processes and is implicated in disease mechanisms, particularly in cancers.

### 1. Associated Genes
While specific associated genes are not frequently listed in basic summaries, MKNK1-AS1 is often discussed in the context of nearby or functionally related genes, including:

- **MKNK1** (Mitogen-activated protein kinase-interacting protein)
- **MKNK2** (Mitogen-activated protein kinase-interacting kinase 2)

Both of these genes are part of the MAPK signaling pathway and are involved in modulating cellular stress responses and proliferation. There may also be associations with other lncRNA genes and various gene sets involved in cancer progression.

### 2. Aging and Age-Related Diseases
Research has indicated that long non-coding RNAs, including MKNK1-AS1, can have roles in cellular aging and age-related diseases. Some details to note include:

- **Cancer**: MKNK1-AS1 has been implicated in cancer biology, where its expression can influence tumor progression, resistance to therapy, and overall survival rates. Tumor microenvironments can impact the regulation of MKNK1-AS1, which may be associated with aging-related cancer susceptibility.
- **Cellular Senescence**: An increase in the expression of various lncRNAs, including MKNK1-AS1, has been observed in senescent cells, suggesting a role in the biological aging process.

### 3. Drug Interactions
While MKNK1-AS1 directly may not have specific drug interactions cataloged, it’s worthwhile to consider its influence on:

- **Targeting Related Kinases**: Drugs that target the MAPK pathway (e.g., MEK inhibitors) may indirectly affect MKNK1 and its regulatory mechanisms, thereby influencing pathways associated with MKNK1-AS1.

### 4. Pathways and Biological Processes
MKNK1-AS1 has been implicated in several signaling pathways and biological processes, including but not limited to:

- **MAPK Signaling Pathway**: Involved in various cellular functions including growth, proliferation, and stress responses.
- **Regulation of Protein Synthesis**: Interacts with the mTOR signaling pathway that governs protein synthesis, influencing cellular growth and survival.
- **Cell Cycle Regulation**: May play roles in modulating aspects of the cell cycle, particularly in the context of cancer proliferation.
- **Inflammatory Responses**: Some research indicates involvement in pathways related to inflammation and immune responses.

### Summary
MKNK1-AS1 is a long non-coding RNA that plays significant roles in various biological processes and diseases, especially around cancer biology. Its influence on aging mechanisms and potential interactions with drugs targeting related pathways highlight its importance as a regulatory element in human health and disease contexts. Further research is essential to fully elucidate its functional roles and pathways.

### References
For more detailed information on MKNK1-AS1, users can refer to:

- [NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/)
- [UniProt](https://www.uniprot.org/) 

If you have any more specific inquiries or need additional information, feel free to ask!