### GSPT2 Gene Overview

**Gene Symbol**: GSPT2  
**Function**: Encodes a GTPase belonging to the GTP-binding elongation factor family, functioning primarily in translation termination as part of the eRF1-eRF3-GTP ternary complex.

### Additional Associations

1. **Associated Genes**:  
   - **eRF1 (eukaryotic Release Factor 1)**: Works in conjunction with GSPT2 in mediating translation termination.
   - **UPF1**: A protein involved in nonsense-mediated decay (NMD), recruited through the SURF complex with GSPT2.
   - **GSPT1**: Another protein with similar functions that could interact with GSPT2 in translation termination.
   - **RPS3**: Part of the ribosomal small subunit, associated with the active translation process where termination occurs.

### Aging and Age-Related Diseases

Research indicates GSPT2 may have roles in cellular stress responses and mRNA regulation, potentially impacting aging processes and related diseases. While specific age-related diseases directly caused by GSPT2 mutations are not firmly established, its role in protein synthesis and mRNA stability suggests implications in conditions characterized by cellular stress or dysregulation of gene expression, such as neurodegenerative diseases.

### Drug Interactions

- **Drugs or Drug Classes**:  
   As of the current data, there are limited specific drugs directly targeting GSPT2. However, potential drugs in the area of cancer treatment may involve influencing ribosomal functions or translation termination pathways, where GSPT2 plays a role.

### Pathways and Biological Processes

**Involved Pathways**:
1. **Translation**: Central role in the termination phase of protein synthesis.
2. **Nonsense-Mediated Decay (NMD)**: Part of the SURF complex facilitating the surveillance and degradation of mRNAs harboring premature stop codons.
3. **mRNA Stability**: Assists in maintaining stability and proper expression of mRNA in various cellular contexts.

**Biological Processes**:
- **Regulation of Translation**: Essential for proper termination of protein synthesis.
- **Cell Stress Response**: Engaging with repairing or removing defective mRNAs.
- **Interfacing with the Ribosome**: Directly involved in the function of the ribosomal machinery during translation. 

### Conclusion

GSPT2 is a critical gene in the overall process of translation and mRNA surveillance, indicating its importance in cellular function and possibly its indirect relation to aging and age-related diseases through cellular stress and gene regulation mechanisms. While specific drug interactions are still being elucidated, the pathways it participates in connect it to broader biological processes crucial for cell survival and function.