### RERG Gene Overview

**Gene Symbol:** RERG  
**Gene Location:** 1q32.1  
**Protein Function:** The RERG protein is a member of the Ras family of GTPases. It binds GDP and GTP and possesses intrinsic GTPase activity with a higher affinity for GDP. Overexpression of RERG in various cell lines has been associated with a decrease in cellular proliferation, reduced colony formation, and diminished tumorigenic potential, indicating a potential role as a tumor suppressor.

### Additional Associated Genes
RERG has been studied in relation to several other genes and pathways. While specific genes may not be mentioned in the NCBI and UniProt summaries provided, common associations include:

- **KRAS:** As a known member of the Ras superfamily, both RERG and KRAS can share involvement in similar signaling pathways, particularly those influencing cell growth and differentiation.
- **HRAS** and **NRAS:** Other members of the Ras family that are often discussed in the context of oncogenesis and cell signaling.
- **p53:** A crucial tumor suppressor gene that may interact with pathways regulated by RERG.

### Aging and Age-Related Diseases
The RERG gene has not been extensively characterized in the context of aging specifically; however, emerging research suggests links between Ras family GTPases and cellular senescence and aging processes. Alterations in the expression and function of GTPases, such as RERG, can also be implicated in various age-related diseases, particularly cancers. Specific studies examining RERG’s role in these processes are limited and merit further investigation.

### Drug Interactions
Current knowledge on drugs specifically targeting RERG is limited. However, class-specific inhibitors of Ras signaling pathways, such as:

- **Farnesyltransferase inhibitors** (which impact post-translational modifications commonly associated with Ras proteins).
- **Kinase inhibitors** (such as those that target downstream effectors in Ras signaling pathways).

These classes may indirectly interact with RERG due to its affiliation with the Ras family.

### Pathways and Biological Processes
RERG is involved in several critical biological pathways, including but not limited to:

1. **Ras Signaling Pathway:** Contributes to cellular proliferation and differentiation signaling, heavily studied in cancer biology.
2. **Cytokine Signaling in Immune System:** Influences immune response through modulation of signaling pathways.
3. **Apoptosis:** Involvement in signaling pathways that mediate programmed cell death.
4. **Cell Cycle Regulation:** Its function as a potential tumor suppressor implies a role in regulating cell cycle progression and tumorigenesis.

### Conclusion
In summary, RERG is an important component of the Ras GTPase signaling network with implications for tumor suppression and cell signaling processes. Further research into its interactions, aging-related roles, and potential therapeutic targeting is needed to fully elucidate its functions in health and disease.