### CEP170 Gene Overview

**Gene Symbol**: CEP170  
**Location**: The CEP170 gene is located on human chromosome 16.

#### 1. Associated Genes
While the primary literature and databases may not list specific genes directly associated with CEP170, it is often studied in relation to other centrosomal and microtubule-associated proteins. Some of these genes may include:

- **CEP192**: Involved in centrosome organization.
- **AURKA (Aurora Kinase A)**: Plays a role in spindle assembly during mitosis.
- **PLK1 (Polo-Like Kinase 1)**: Directly interacts with CEP170 and is crucial for various stages of cell division.
- **TPX2**: Associates with Aurora kinase and is involved in microtubule organization.
- **CENPF (Centromere Protein F)**: Associated with the mitotic spindle and microtubule dynamics.
  
These interactions emphasize CEP170's role in centrosome function, microtubule organization, and cell division.

#### 2. Aging and Age-Related Diseases
Current research suggests that the proper function of centrosomal proteins, including CEP170, is critical for maintaining genomic stability and normal cellular functions. As organisms age, there may be dysregulation or mislocalization of centrosomal proteins, which can contribute to age-related cellular dysfunction. Specific details regarding CEP170 directly linking it to aging or particular age-related diseases (like Alzheimer's or cancer) remain limited. However, since abnormalities in centrosome function can lead to defects in cell division, it can play an indirect role in the onset of age-related diseases characterized by aberrant cell proliferation or differentiation.

#### 3. Drug Interactions
As of now, there are no specific drugs or drug classes that are widely recognized to directly target or influence the CEP170 protein. However, because CEP170 interacts with PLK1, drugs targeting polo-like kinases (like **volasertib** or **Onvansertib**) could indirectly affect the functioning of CEP170 through modulation of its phosphorylation and interactions during the cell cycle.

#### 4. Pathways and Biological Processes
CEP170 is involved in multiple biological processes and cellular pathways, including:

- **Centrosome organization**: A crucial role in forming and maintaining the structure of the centrosome, facilitating proper cell division.
- **Microtubule organization**: Essential for the assembly and dynamics of microtubules, which are vital for various cellular processes.
- **Mitosis**: It plays a significant role during this phase by associating with spindle microtubules and ensuring accurate chromosome segregation.
- **Cytoskeleton organization**: Contributing to the stability and functioning of the cytoskeleton.

In terms of signaling pathways, CEP170's interaction with Aurora kinases and Polo-like kinases suggests involvement in pathways related to cell cycle regulation and mitotic progression.

### Summary
CEP170 is a critical centrosomal protein that plays an essential role in microtubule organization and maintaining cell morphology, particularly during cell division. Further research is required to explore its significance in aging processes and potential implications in age-related diseases, as well as more precise drug interactions.