### TMEM14B Gene Overview

**Gene Symbol:** TMEM14B  
**Location:** Chromosome 6  
**Expression:** Primarily in the brain, particularly the developing neocortex.

**Function:**  
The TMEM14B gene encodes a membrane protein that is involved in several critical biological processes, including:
- **Cerebral Cortex Development**: This gene plays a significant role in the development of the cerebral cortex, a key area of the brain associated with higher-order functions including thought, perception, and voluntary movement.
- **Neural Precursor Cell Proliferation**: TMEM14B is implicated in the proliferation of neural progenitor cells, which are crucial for brain development.
- **Regulation of the G1/S Transition of the Mitotic Cell Cycle**: It is involved in facilitating the transition between the G1 phase and S phase of the cell cycle, allowing for DNA replication.

**Interactions**:  
TMEM14B has been shown to have identical protein binding activity and may interact with IQGAP1, promoting the proliferation of neural progenitor cells through marker translocation.

### 1. Associated Genes
While the summaries provided don't specify other associations, from additional data, TMEM14B may be related to:
- **IQGAP1**: As mentioned, it may interact with this gene.
- **TP53**: Known for its role in cell cycle regulation, it could have functional links with TMEM14B in context of cell proliferation and growth control.
- **MMP2 and MMP9**: Involved in extracellular matrix remodeling during development.

### 2. Aging and Age-Related Diseases
Current literature does not extensively detail TMEM14B's direct association with aging or specific age-related diseases. However, its role in neurodevelopment suggests it might have implications in neurodegenerative diseases or age-related cognitive decline, as proper brain development and function are essential throughout life. Abnormal regulation of neural progenitor cells could be implicated in diseases characterized by neurogenesis failure.

### 3. Drug Interactions
As of the current knowledge (up to October 2023), no specific drugs or drug classes are directly linked to TMEM14B. However, given its role in cell cycle regulation and proliferation, it may be of interest in research regarding cancer therapeutics that target cell cycle checkpoints. Further studies may potentially reveal pharmacological interventions impacting its activity.

### 4. Pathways and Biological Processes
TMEM14B is involved in various biological processes and pathways, including:
- **Cell Cycle Regulation**: Especially in the transition from G1 to S phase.
- **Neural Development Pathways**: It plays a role in cortical development and possibly other neurogenesis-related processes.
- **Signaling Pathways**: Implicated in signaling related to progenitor cell proliferation and differentiation.

### Summary
In summary, TMEM14B is a critical gene for neurodevelopment, particularly in the context of cortical development. Its functional roles and interactions place it in key biological pathways that could impact both normal brain development and, potentially, the pathology of neurodegenerative conditions. Further investigation may reveal more on its involvement with aging and therapeutic possibilities.