### NUP133 Gene Overview

**Gene Symbol**: NUP133  
**Location**: Human chromosome 1  
**Function**: The NUP133 gene encodes a member of the nucleoporin family, contributing to the structure and function of the nuclear pore complex (NPC). This complex plays a critical role in regulating the transport of proteins and RNA between the nucleus and the cytoplasm. 

### 1. Genes Associated with NUP133

NUP133 is part of a larger complex of nucleoporins and has known interactions with other members of the nucleoporin family, including but not limited to:
- **NUP107**: A critical component of the nuclear pore complex that has been implicated in the assembly of the NPC.
- **NUP160**: Another nucleoporin that associates with NUP133 and plays a role in nuclear transport.
- **NUP62**: A nucleoporin that is implicated in the transport of proteins across the nuclear envelope.
- **NUP358 (RANBP2)**: Involved in nuclear transport and interacts with NUP133.

### 2. Aging and Age-Related Diseases

Research on NUP133 and its association with aging or age-related diseases is limited; however, some observations indicate that alterations in nucleocytoplasmic transport, where NUP133 is crucial, might impact cellular function during aging. Dysregulation of nucleoporins has been implicated in various age-related conditions, particularly neurodegenerative diseases. The role of nucleoporins, including NUP133, in maintaining nuclear integrity and mediating the transport of RNA and proteins could suggest potential contributions to processes such as:
- Neurodegeneration
- Cardiovascular aging
- Cancer biology, where cellular transport mechanisms may become dysregulated.

### 3. Drugs or Drug Classes Interacting with NUP133

While there are no specific FDA-approved drugs that target NUP133 directly, several classes of drugs that target nuclear transport mechanisms may indirectly affect its function. These may include:
- **Nuclear transport inhibitors**: Such as certain viral peptides (e.g., TAT, which can modulate the binding and transport of nuclear proteins).
- **Chemotherapeutic agents**: Some cancer treatments that disrupt cell division and nuclear transport may also impact the localization or expression of nucleoporins like NUP133.

It is important to note that direct interactions with specific drugs are still an area of ongoing research.

### 4. Pathways and Biological Processes

NUP133 is involved in several key pathways and biological processes, including:

- **Nuclear pore complex assembly**: Critical for the formation and maintenance of the NPC, facilitating macromolecular transport.
- **mRNA export**: Contributing to the transport of polyadenylated RNA from the nucleus to the cytoplasm.
- **Mitotic spindle formation**: Involved in maintaining proper nuclear structure during cell division.
- **Kinetochore function**: NUP133 has been observed at kinetochores, suggesting a role in chromosome segregation.
- **Nephrogenesis**: The development of the kidney, where NUP133 may have specific functions linked to cell signaling and differentiation.

NUP133 serves as an example of the intricate connections in cellular transport systems and their broader implications for cellular health and disease. Continued research into this and related nucleoporins will further illuminate their roles in both fundamental biology and pathological states.