### Overview of MAPRE3-AS1 Gene

Gene Symbol: **MAPRE3-AS1**  
Aliases: **MAPRE3 antisense RNA 1**  
Chromosomal Location: The MAPRE3-AS1 gene is located on chromosome 20 in humans.

MAPRE3-AS1 is a long non-coding RNA (lncRNA) that is involved in a variety of cellular and biological processes. Its gene product does not code for a protein but rather participates in regulatory functions within the cell.

### 1. Associated Genes

While the NCBI and UniProt summaries may not list specific genes related to MAPRE3-AS1, lncRNAs often have regulatory roles and can influence the expression of neighboring genes. Genes frequently associated with MAPRE3-AS1 include:

- **MAPRE3 (Microtubule-Associated Protein RP/EB Family Member 3):** This gene is situated nearby on chromosome 20 and is involved in microtubule dynamics and cellular motility.
- **Other members of the EB family:** These may also show regulatory interactions.

### 2. Aging and Age-Related Diseases

Research indicates that lncRNAs play a significant role in aging and age-related diseases. Although specific studies directly linking MAPRE3-AS1 to aging or age-related diseases are limited, general roles of lncRNAs in these domains include:

- **Regulation of cellular senescence:** Age-related changes in gene expression, including dysregulation of lncRNAs, can impact cellular senescence.
- **Potential roles in cancer genetics:** Dysregulation of lncRNAs, including MAPRE3-AS1, has been observed in various cancers, which are often age-related diseases.

Further research is needed to clarify the specific connections between MAPRE3-AS1 and aging or age-related diseases.

### 3. Drug Interactions

As of October 2023, there are no specific drugs or drug classes explicitly known to interact with MAPRE3-AS1. However, lncRNAs like MAPRE3-AS1 could indirectly affect the efficacy of certain drugs if they modulate the expression of target genes involved in drug metabolism, efficacy, or resistance. Further studies may reveal potential interactions or implications in therapeutic contexts.

### 4. Pathways and Biological Processes

MAPRE3-AS1 is involved in several biological processes, primarily through its regulatory functions. Some key pathways and processes related to MAPRE3-AS1 include:

- **Microtubule Dynamics and Organization:** Given its association with MAPRE3, MAPRE3-AS1 may play a role in microtubule organization, impacting cell division and various motility processes.
- **Gene Expression Regulation:** As a long non-coding RNA, MAPRE3-AS1 likely influences the transcriptional regulation of genes, potentially modulating cellular responses.
- **Cancer Progression:** lncRNAs are often implicated in the regulatory networks of oncogenes and tumor suppressors, making MAPRE3-AS1 a candidate for similar investigations in cancer biology.

### Summary

MAPRE3-AS1 is a long non-coding RNA associated with the MAPRE3 gene, with potential implications in microtubule dynamics, cellular regulation, and cancer. While direct associations with aging and specific drug interactions remain underexplored, the role of lncRNAs in gene regulation and disease pathways clarifies their importance in various biological processes. Further research is warranted to elucidate the precise mechanisms and clinical implications of MAPRE3-AS1.