### SVIL Gene Overview

**Gene Symbol:** SVIL  
**Full Name:** Supervillin  
**Location:** Human chromosome 6

#### Summary
The SVIL gene encodes a protein known as supervillin, which is characterized by a bipartite structure consisting of an amino-terminal domain with nuclear localization signals and a carboxy-terminal domain with similarity to actin-binding proteins of the gelsolin family. Supervillin plays a crucial role in linking the actin cytoskeleton to the plasma membrane, thus supporting various cellular processes including cell shape, migration, and contraction.

### Additional Information

1. **Associated Genes:**
   - **ACTB** (Actin Beta) - As an actin-binding protein, supervillin is likely to interact with beta-actin.
   - **MYH9** (Myosin Heavy Chain 9) - Given its role in myosin II assembly, there may be functional relationships with myosin heavy chains.
   - **MLCK** (Myosin Light Chain Kinase) - This gene may be involved in the regulation of myosin II through MLCK.
   - **VCL** (Vinculin) - As a cytoskeletal protein, vinculin may also interact with supervillin in the context of focal adhesions.

2. **Aging and Age-Related Diseases:**
   - While specific studies directly linking SVIL to aging are limited, its involvement in cytoskeletal dynamics and cell migration suggests that alterations in supervillin function may impact tissue repair and regeneration, processes that often decline with age.  
   - Dysregulation of actin-binding proteins, including supervillin, has implications in age-related diseases such as sarcopenia, where muscle mass and strength are lost with aging. Changes in cellular migration and membrane stability associated with supervillin might also contribute to pathological conditions such as cancer metastasis, which is age-related.

3. **Drug/Drug Classes Interactions:**
   - **Actin-Targeting Drugs**: Drugs such as cytochalasins, which inhibit actin polymerization, might indirectly affect supervillin function by altering actin dynamics.
   - **Myosin Inhibitors**: Drugs that inhibit the functioning of myosin motors may also impact the pathways involving SVIL, particularly in motility and contractile functions.

4. **Pathways and Biological Processes:**
   - **Myogenesis**: SVIL is involved in the formation and differentiation of muscle cells, participating in the assembly of costameric structures.
   - **Cell Adhesion and Migration**: It plays roles in focal adhesion dynamics, which are important for migration and signaling in cells.
   - **Actin Filament Organization**: SVIL is part of pathways regulating actin cytoskeleton dynamics, crucial for maintaining cell shape and motility.
   - **Membrane Dynamics**: It contributes to the integrity and function of membranes, suggesting a role in various membrane-related biological processes, including endocytosis and exocytosis.

In summary, the SVIL gene plays a critical role in linking the cytoskeleton with membrane dynamics and is involved in essential cellular processes like migration, adhesion, and myogenesis. Its potential implications in aging and age-related diseases further highlight its significance in cell biology.