### FKBP10 Gene Overview

**Gene Symbol**: FKBP10  
**NCBI Gene ID**: 23155  
**Chromosome Location**: 17q21.31  
**Gene Type**: Protein-Coding

#### Gene Function
The FKBP10 gene encodes a member of the FK506-binding protein (FKBP) family, which is known for its role as a peptidyl-prolyl cis/trans isomerase (PPIase). The primary function of FKBP10 is to facilitate proline isomerization, a crucial step in the folding of proteins during their synthesis within the endoplasmic reticulum (ER), thereby acting as a molecular chaperone.

#### Associated Genes
While specific lists of directly associated genes may not always be explicitly defined in the literature, FKBP10 may interact or be functionally related to other genes involved in protein folding and trafficking, such as:
- **Hspa5** (Heat shock protein A5, also known as Bip/Grp78) – involved in the ER protein quality control.
- **Calr** (Calreticulin) – another chaperone protein that assists in proper protein folding and Ca²+ homeostasis.
- **CNPY3** (Canoonomic cytosolic protein 3) – associated with protein folding pathways.

#### Aging and Age-Related Diseases
FKBP10 has been researched for its potential implications in aging and age-related diseases. While there may not be direct and conclusive findings specifically linking FKBP10 to aging pathways, it's noteworthy that:
- Alterations in chaperone proteins are often seen in age-related diseases, such as neurodegenerative disorders (e.g., Alzheimer's disease).
- Expression levels of FKBP family members have been shown to change with age and in response to stressors, indicating potential roles in cellular aging.

#### Drug Interactions
FKBP10 is associated with various drugs due to its role as a PPIase. The following classes of drugs can interact with FKBP10:
- **Immunosuppressants** (e.g., Tacrolimus and Sirolimus) target FKBP proteins.
- **Rotamase inhibitors**, which specifically inhibit the isomerase activity of FKBP-type proteins.

These drugs are often used in transplant medicine and the treatment of autoimmune diseases due to their ability to modulate immune responses.

#### Pathways and Biological Processes
FKBP10 is implicated in several critical biological processes and pathways, including:
- **Protein Folding**: Facilitating proper protein conformation during nascent polypeptide synthesis.
- **Endoplasmic Reticulum Stress Response**: It plays a role in the cell's response to misfolded proteins, which is crucial for maintaining cellular homeostasis.
- **Extracellular Matrix Organization**: FKBP10 has been suggested to be involved in the formation and stability of the extracellular matrix by interacting with collagen and possibly contributing to collagen-related diseases.

In summary, FKBP10 is an important gene encoding a PPIase that plays a critical role in protein folding and cellular stress responses. While its direct implications in aging and specific age-related diseases remain an area for further exploration, its interactions with key drugs and involvement in essential biological processes underline its relevance in both health and disease contexts.