### GNG8 Gene Overview

**Gene Symbol:** GNG8  
**Location:** Chromosome 18

#### 1. Associated Genes
GNG8 is known to interact with various other genes within the context of G-protein signaling pathways. Notable interactions include:

- **GNB genes (G protein beta subunits):** GNG8 is closely associated with the GNB1, GNB2, GNB3, and GNB5 genes.
- **GNA genes (G protein alpha subunits):** Such as GNAI, GNAL, and others, as it can form heterotrimeric complexes with different G protein alpha and beta subunits. 
- **RGS genes (Regulator of G-protein Signaling):** Like RGS1, which play a role in modulating G-protein signaling pathways.

#### 2. Aging and Age-Related Diseases
While there is limited direct research specifically tying GNG8 to aging or age-related diseases, G proteins, in general, have been implicated in various signaling pathways that affect cellular aging and the onset of age-related disorders. Some studies suggest that dysregulation of G protein signaling is associated with neurological disorders, metabolic diseases, and cardiovascular conditions that correlate with aging. 

- **Neurological Disorders:** Alterations in G-protein signaling have been noted in conditions like Alzheimer's disease and other forms of dementia, where G-proteins can impact neural excitability and synaptic transmission.
- **Metabolic Syndromes:** Changes in G-protein signaling pathways can also affect insulin signaling and contribute to conditions such as type 2 diabetes, which becomes more prevalent with age.

#### 3. Drug Interactions
Currently, there are no specific drugs exclusively targeting GNG8 mentioned in drug databases. However, drugs that influence G-protein signaling pathways could indirectly affect the functions associated with GNG8. These include:

- **Antipsychotic drugs:** Many of which exert their effects via modulation of G protein-coupled receptors (GPCRs), indirectly implicating beta and gamma subunits in their mechanisms of action (e.g., Olanzapine, Risperidone).
- **Antihypertensives:** Certain classes of drugs that target GPCRs in the cardiovascular system could also have relevance (e.g., Beta-blockers like Metoprolol).
- **Opioids:** Medications that interact with opioid receptors, which are a type of GPCR, may also impact G-protein signaling.

#### 4. Pathways and Biological Processes
GNG8 is involved in several critical biological processes and signaling pathways:

- **G-Protein Coupled Receptor (GPCR) Signaling:** As part of the heterotrimeric G-protein complex, GNG8 plays a role in transmitting signals from GPCRs involved in a vast range of physiological effects.
- **Phototransduction:** In retinal cells, GNG8 is implicated in the signaling processes involved in converting light into electrical signals.
- **Regulation of Cytokine and Immune Responses:** Certain studies indicate that GNG8 may play a role in immune system signaling pathways.
- **Social Behavior and Response to Pheromones:** There is evidence suggesting involvement in behavioral responses, possibly mediated through specific GPCRs related to pheromone detection.

Overall, while GNG8's primary functions revolve around G-protein signaling, ongoing research may continue to unveil further associations with complex biological processes and implications in health and disease.