### Gene Overview: IQGAP3

**Gene Symbol:** IQGAP3  
**Chromosomal Location:** Human gene located on chromosome 2q11.2.  
**Function:** IQGAP3 encodes a member of the IQGAP family of proteins, which are important for cellular signaling and cytoskeletal organization. The protein has multiple binding activities including calmodulin and myosin VI light chains, which are indicative of its role in actin cytoskeleton regulation. 

### 1. Associated Genes
Although specific genes directly mentioned in association with IQGAP3 are not provided in the summary, typical interactions in the context of its known pathways include:

- **MAPK Pathway Members:** These are involved in intracellular signal transduction.
- **Rho GTPases (e.g., RAC1, CDC42):** Known to interact with IQGAP proteins which regulate the cytoskeleton.
- **Cadherin Family Members:** Involved in cell-cell adhesion that is regulated by IQGAP3.

### 2. Aging and Age-Related Diseases
While specific studies directly linking IQGAP3 to aging or age-related diseases are limited, the gene's involvement in cellular signaling pathways might suggest importance in processes like:

- **Cell Proliferation:** Implicated in age-related tissue repair and regeneration, specifically in mammary gland epithelial cells.
- **Cancer Pathogenesis:** Given that IQGAP3 has roles in cell proliferation and cytoskeletal dynamics, aberrations in its expression or function might contribute to tumor progression, a process often aggravated with age.

Additionally, some studies suggest that changes in cytoskeletal dynamics and signaling pathways are associated with neurodegenerative diseases, implying that IQGAP3 might have indirect roles in such conditions.

### 3. Interacting Drugs and Drug Classes
As of now, there are no specific FDA-approved drugs directly targeting IQGAP3; however, it may interact with broader drug categories that modulate the signaling pathways it is involved in:

- **Cytoskeletal Modulators:** Such as those affecting actin polymerization (like cytochalasins or latrunculins) may impact IQGAP3’s function indirectly.
- **Calmodulin Inhibitors:** Since IQGAP3 has calmodulin binding activity, drugs that inhibit calmodulin might influence its activity in cellular processes.

### 4. Biological Pathways and Processes
IQGAP3 is predicted to play roles in several key pathways and processes, including:

- **Regulation of Actin Cytoskeleton Organization:** Critical for cell shape, motility, and division.
- **Intracellular Signaling Pathways:** Involvement in MAPK signaling cascades that mediate cellular responses to growth factors.
- **Cell Proliferation:** Particularly in mammary gland tissue, implicating a role in both normal growth and potentially in oncogenesis.
- **Regulatory Processes for Macromolecule Metabolic Activities:** Suggests a role in energy metabolism and cellular homeostasis.
  
In summary, while IQGAP3 is a critical player in cytoskeletal organization and signaling processes, its full implications in aging, diseases, and therapeutic interactions warrant further research for more comprehensive insights.