### SRSF3 Gene Overview

**Gene Symbol**: SRSF3  
**Location**: Chromosome 17  
**Aliases**: SRp20, SR-SP3, SRp55, p25

The SRSF3 gene encodes a protein that is part of the serine/arginine-rich (SR) protein family, which plays crucial roles in mRNA splicing, mRNA export, and translation. The protein contains an RNA recognition motif (RRM) and an RS domain that facilitate its involvement in the spliceosome and in interactions with various RNA-binding proteins. 

### 1. Associated Genes

SRSF3 interacts with multiple other genes and proteins, which are involved in pre-mRNA splicing and mRNA export:

- **YTHDC1**: An RNA-binding protein involved in recognizing and binding N6-methyladenosine (m6A)-containing RNAs, facilitating the recruitment of SRSF3 to mRNA-binding elements.
- **NXF1**: A key component of the nuclear export pathway for mRNA; SRSF3 enhances its RNA-binding activity.
- **HNRNPA1**: Heterogeneous nuclear ribonucleoprotein involved in diverse aspects of RNA metabolism.

### 2. Aging and Age-Related Diseases

Research has implicated SRSF3 in processes related to aging and age-related diseases, with the following details:
- **Cellular Senescence**: Altered splicing patterns driven by SRSF3 can lead to the accumulation of senescent cells, contributing to tissue aging.
- **Cancer**: Dysregulation of SRSF3 has been linked to several forms of cancer. Given its role in alternative splicing, aberrant SRSF3 expression can facilitate tumor progression and metastasis by modifying the splicing patterns of oncogenes and tumor suppressor genes.
- **Neurodegenerative Diseases**: There is growing evidence that SRSF3 may be involved in the splicing of pre-mRNAs related to neurodegenerative disorders, possibly affecting the balance of proteins that contribute to neuronal function and survival.

### 3. Drug Interactions

While specific drugs targeting SRSF3 have not been widely established, it is known that certain cancer therapeutics and research compounds affecting splicing or mRNA metabolism may interact indirectly with SRSF3:
- **Splicing Modulators**: Drugs like E7107, which inhibit spliceosome function, may affect SRSF3's activity in cancer treatment.
- **Anticancer Compounds**: Some compounds targeting the molecular machinery involved in RNA processing and export may influence the pathways SRSF3 is part of, although specific interactions may vary.

### 4. Pathways and Biological Processes

SRSF3 is involved in several critical pathways and biological processes:

- **mRNA Splicing**: Plays a direct role in the canonical spliceosome-mediated splicing of pre-mRNAs.
- **mRNA Export**: Facilitates the export of mRNA containing m6A modifications from the nucleus to the cytoplasm.
- **Alternative Splicing Regulation**: Acts as a splicing factor that influences exon inclusion/exclusion patterns, particularly during stress responses and developmental processes.
- **Gene Expression Regulation**: Interacts with other proteins to modulate gene expression post-transcriptionally.

### Summary

The SRSF3 gene encodes a significant spliceosomal protein with diverse roles in pre-mRNA splicing and mRNA export. Its interactions with various RNA-binding proteins and its involvement in aging and disease pathways highlight its importance in cellular function and pathology. Further research into SRSF3 may elucidate its potential as a therapeutic target, particularly in cancer and age-related diseases.