### PDCD2L Gene Overview

**Gene Symbol**: PDCD2L  
**Location**: Membrane

**Protein Summary**: PDCD2L (Programmed Cell Death 2-Like) is a protein that plays a significant role in cellular processes, including the suppression of various transcriptional activities, such as those mediated by AP-1, CREB, NFAT, and NF-κB. Overexpression of PDCD2L has been linked to the delay of cell cycle progression specifically in the S phase, suggesting a role in cell proliferation regulation.

### Additional Information

1. **Associated Genes**:  
   PDCD2L has been linked to several other genes through various studies, particularly those involved in cell cycle regulation and apoptosis pathways. Some genes of interest include:
   - **AP1 complex members** (e.g., JUN, FOS)
   - **CREB** (cAMP response element-binding protein)
   - **NF-kB family members** (e.g., RELA, RELB)
   - **Cell cycle-related genes** (e.g., CDKs, cyclins)

2. **Aging and Age-Related Diseases**:  
   While specific studies on PDCD2L in aging or age-related diseases may be limited, its role in cell cycle regulation suggests that it could be involved in processes like cellular senescence or apoptosis, which are relevant to aging. Dysregulation of apoptosis and cell cycle progression is often implicated in age-related diseases such as cancer and neurodegenerative disorders. Additionally, as PDCD2L interacts with signaling pathways that are crucial during cellular stress responses, it may also play a role in disease mechanisms associated with aging, although further research is necessary to elucidate specific associations.

3. **Drug Interactions**:  
   As of the latest available data, direct interactions between specific drugs and the PDCD2L protein have not been extensively characterized. It is important to note, however, that gene expression modulation could be influenced by various drugs targeting related pathways (inflammatory processes, cell cycle modulation). Potential avenues of interest would include:
   - **Chemotherapeutic agents** which affect cell cycle dynamics,
   - **Immunomodulators** that can influence NF-kB signaling,
   though specific drug-class interactions with PDCD2L require further study.

4. **Pathways and Biological Processes**:  
   PDCD2L is primarily involved in the following pathways and biological processes:
   - **Regulation of Transcription**: It plays a role in modulating the activity of several transcription factors (e.g., AP1, NF-kB).
   - **Cell Cycle Regulation**: It delays cell cycle progression at the S phase, linking it to processes governing cell division and growth.
   - **Apoptosis**: Given its name, the gene may participate in apoptotic pathways, contributing to programmed cell death regulation.
   - **Cellular Stress Responses**: Involvement in responses to cellular stressors may also be inferred based on its association with suppressive transcriptional activity and cell cycle regulation.

### Conclusion

The PDCD2L gene appears to be a significant player in regulating transcription factors linked to cell cycle progression and apoptosis. Its implications in aging and potential interactions with various pathways suggest that understanding PDCD2L function could be crucial for insight into age-related diseases and therapeutic strategies. Further research is needed to fully characterize its functions, interactions, and clinical relevance.