### NPRL3 Gene Overview

**Gene Symbol:** NPRL3  
**Chromosomal Location:** Human gene located on chromosome 1 at 1p32.1.  

### Detailed Information about NPRL3

1. **Gene Associations:**
   - NPRL3 is part of the GATOR1 complex, which also includes NPRL2 and DEPDC5. GATOR1 interacts with the GATOR2 complex, which consists of proteins such as MIOS, and several others that modulate mTORC1 signaling.
   - Related genes in mTOR signaling include RAG proteins (RagA, RagB, RagC, RagD) and mTOR itself.

2. **Aging and Age-related Diseases:**
   - While there are no direct associations established between NPRL3 and aging itself, the regulation of mTORC1 signaling via the GATOR1 complex has been implicated in various age-related processes. Enhanced mTOR signaling can contribute to cellular senescence and age-related diseases, such as cancer and neurodegenerative diseases.
   - Impairment in amino acid sensing and mitochondrial function associated with mTOR dysregulation could influence aging pathways.

3. **Drug Interactions:**
   - NPRL3 itself may not have direct pharmacological interactions; however, since it is integral to the mTORC1 signaling pathway, compounds targeting mTOR could indirectly affect NPRL3-related signaling. Examples include:
     - **mTOR inhibitors:** Such as rapamycin (sirolimus) and its analogs (everolimus, temsirolimus).
   - Other compounds that modulate amino acid availability or the metabolic state of the cell may indirectly impact NPRL3’s function.

4. **Pathways and Biological Processes:**
   - **mTOR Signaling Pathway:** Inhibits mTORC1 signaling in response to amino acid availability.
   - **Cellular Response to Amino Acid Starvation:** Modulates nutrient sensing across different cellular processes.
   - **Rag GTPase Activation:** Acts as a GTPase-activating protein (GAP) for RagA and RagB.
   - **Regulation of TOR Signaling:** Plays a crucial role in maintaining cellular homeostasis in nutrient-deficient conditions.
   - **Neuronal Role:** Associated with focal epilepsy, implicating its role in neuronal signaling and development.

This comprehensive view encapsulates the NPRL3 gene's role in cellular signaling and its potential implications in various biological processes and disease states. Further research may expand on its functions, particularly in aging and pharmacological interactions.