### DDX39A Gene Overview

**Gene Symbol:** DDX39A  
**Chromosomal Location:** 3p21.31  
**Gene Type:** Protein-coding gene  
**Protein Product:** DEAD-box helicase 39A  

### 1. Associated Genes
While the summaries do not specify additional genes directly associated with DDX39A, members of the DEAD box protein family, such as DDX39B, DDX5, and DDX17, may serve biological functions that intersect with DDX39A in RNA processing and splicing pathways. DDX39A is also believed to interact with various components of the spliceosome and ribonucleoprotein complexes, including other splicing factors such as SF3B1 and U2AF.

### 2. Aging and Age-related Diseases
Research indicates that DDX39A may play a role in age-related processes, particularly in cellular senescence and the regulation of gene expression that declines with age. Alterations in RNA splicing and mRNA export that DDX39A regulates can lead to age-related diseases, including cancer. In particular, the way DDX39A is involved in the prognosis of gastrointestinal stromal tumors suggests a link to age-related tumor dynamics, as these tumors are often diagnosed in older adults.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes explicitly known to target DDX39A. However, due to its role in RNA splicing and transcription regulation, it may be indirectly affected by certain chemotherapeutic agents, especially those targeting RNA metabolism. Future discovery of inhibitors or drugs interacting with DDX39A-dependent pathways may reveal more about its pharmacological relevance.

### 4. Pathways and Biological Processes
DDX39A is involved in several important biological processes, including:

- **Pre-mRNA splicing:** Essential for the processing of precursor mRNA into mature mRNA.
- **mRNA export:** Facilitates the transport of mRNA from the nucleus to the cytoplasm, critical for protein synthesis.
- **Assembly of the spliceosome:** Participates in the formation of the spliceosomal complex necessary for splicing.
- **Ribosome assembly:** Contributes to ribosome biogenesis and function, impacting overall protein synthesis.
- **Regulation of translation:** Potentially influences the initiation and regulation of translation processes.

### Summary
DDX39A is a crucial gene in RNA metabolism with implications in splicing and mRNA export, influencing various cellular processes and presenting relevance to cancer prognosis and aging-related phenomena. Current knowledge about drug interactions and specific associated pathways is still limited and an area of ongoing research. Further studies may elucidate more clinical applications and molecular mechanisms associated with DDX39A.