### SLC35D3 Gene Overview

**Gene Symbol:** SLC35D3  
**Location:** The SLC35D3 gene is located on chromosome 1 in humans.  

**Function:** The SLC35D3 gene encodes a protein that is involved in the transport of nucleotide-sugars, specifically UDP-glucose. It is predicted to have antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. The protein is primarily located in the Golgi apparatus, early endosome, and endoplasmic reticulum, functioning in the transmembrane transport of UDP-glucose.

### 1. Associated Genes
While specific association with other genes may vary depending on the context (e.g., tissue specificity, physiological conditions), genes that are often discussed in relation to SLC35D3 include:
- **SLC35D1:** Another member of the SLC35 family that is involved in nucleotide-sugar transport.
- **SLC35A1:** This gene encodes a nucleotide sugar transporter, indicating potential redundancy or alternative pathways in sugar transport.
- **SNAP-25:** While not directly associated, SNAP-25 is involved in synaptic function, where SLC35D3 is implicated in the transport of UDP-glucose to synaptic vesicles.

### 2. Age-Related Associations
Research into the specific roles of SLC35D3 in aging or age-related diseases is limited. However, its involvement in:
- **Energy Homeostasis:** Disruptions in energy balance are a hallmark of aging and age-related metabolic diseases.
- **Platelet Function:** Alterations in platelet dense granule maturation may have implications for age-related cardiovascular diseases, where platelet functions often decline.
- **Neurodegenerative Disorders:** Given its role in synaptic function, changes in SLC35D3 activity may be relevant to cognitive decline and neurodegenerative diseases such as Alzheimer's disease.

### 3. Drug Interactions
As of the latest data available:
- There are no specific drug interactions currently documented in major databases that directly target SLC35D3.
- However, drugs that modulate glucose metabolism or affect synaptic function (like antiepileptic drugs) may indirectly impact the expression or activity of SLC35D3, reflecting its role in synaptic vesicle maturation and glucose transport.

### 4. Pathways and Biological Processes
SLC35D3 is involved in several important pathways and biological processes, such as:
- **Nucleotide Sugar Metabolism:** Facilitating the transport of UDP-glucose is vital for glycosylation processes essential for protein and lipid modifications.
- **Platelet Activation and Aggregation:** Contributing to the maturation of dense granules, which release essential signaling molecules during platelet activation.
- **Synaptic Transmission:** Participating in the transport of nucleotide sugars that are crucial for synthesizing neurotransmitters and other components in neuronal signaling.

In summary, SLC35D3 is a critical gene associated with sugar transport and synaptic function, with implications for both metabolic regulation and neuronal health. Further research may elucidate its role in aging and specific diseases, particularly those concerning the nervous system and cardiovascular health.