### SNORD116-23 Gene Overview

**Gene Symbol**: SNORD116-23

The SNORD116-23 gene is part of the small nucleolar RNA (snoRNA) family, specifically classified as a C/D box snoRNA. These genes are typically involved in the modification of ribosomal RNA (rRNA), which is essential for ribosome function and protein synthesis. SNORD116-23 is located within a cluster on chromosome 14.

### 1. Associated Genes

While specific interactions or associations may not always be explicitly cataloged, snoRNAs often regulate or interact with other genes involved in processes such as gene expression and RNA modification. Notable associated genes include:

- **SNORD116 gene cluster**: Other members within the SNORD116 family (e.g., SNORD116-1 to SNORD116-18) may have overlapping regulatory functions.
- **DROSHA**: An RNA processing enzyme that may be part of the regulatory network involving snoRNAs.
- **PRKCQ (Protein Kinase C theta)**: Possibly linked through regulatory pathways influenced by snoRNAs.

### 2. Aging and Age-Related Diseases

Research into the role of snoRNAs, including SNORD116-23 in aging and age-related diseases, is still emerging. However, certain known associations include:

- Alterations in snoRNA expression have been observed in various cancers and degenerative diseases, suggesting a potential role in cell regulation linked to aging.
- Dysregulation of snoRNAs, including SNORD116-23, has been implicated in neurodegenerative diseases and could relate to the decline in cellular functions associated with aging.

### 3. Drug Interactions

As of now, specific drugs or drug classes that are known to directly interact with the SNORD116-23 gene are not well-documented. However, it's important to consider that:

- Drugs targeting RNA modification pathways may indirectly affect the function of snoRNAs.
- Certain antineoplastic therapies have been shown to influence the expression profiles of snoRNAs, which could include SNORD116-23.

### 4. Pathways and Biological Processes

SNORD116-23 is involved in several biological pathways and processes, primarily related to RNA modification. Key pathways include:

- **rRNA Modification**: As a snoRNA, SNORD116-23 plays a significant role in the 2'-O-methylation of rRNA, a post-transcriptional modification necessary for proper ribosome assembly and function.
- **RNA Processing Pathways**: Involvement in the maturation and processing of rRNA and possibly influencing mRNA splicing and stability.
- **Gene Regulation**: May contribute to regulatory networks modulating gene expression.

### Summary

In summary, SNORD116-23 is a small nucleolar RNA involved mainly in RNA processing and modification, with implications in various biological processes. While direct associations with specific drugs or detailed aging-related mechanisms are still under investigation, its contributions to cellular functions make it an important gene of interest in genomic research. Further research into its roles may reveal more about its implications in health and disease.