### SNORD114-17 Gene Overview

**Gene Symbol:** SNORD114-17

**Description:** The SNORD114-17 gene is part of the C/D box small nucleolar RNA (snoRNA) family, which is primarily involved in the biogenesis of ribosomes and modification of ribosomal RNA (rRNA). SNORD114-17 is especially noted for its role in guiding the methylation of target RNAs, a critical process for rRNA maturation.

### 1. Associated Genes

While specific associations might not always be explicitly listed in the summaries from NCBI or UniProt, snoRNA genes typically interact mechanistically with:

- **C/D box proteins:** such as NOP58, NOP56, and FBL (fibrillarin) which are essential for snoRNA function.
- **Other snoRNA genes:** within the SNORD114 family, particularly those that might share similar target rRNA sequences or regulatory roles.

**Note:** Further details on specific interacting genes can depend on experimental studies and might not be documented extensively in public databases.

### 2. Aging and Age-Related Diseases

Research has indicated a correlation between snoRNA expression and various cellular and systemic aging processes, including:

- **Cellular senescence:** Alterations in snoRNA levels, including those like SNORD114-17, have been implicated in promoting ribosomal biogenesis and cellular proliferation, factors that can influence aging.
- **Cancer:** Some studies suggest that changes in snoRNA expression can be related to tumorigenesis and progression, possibly linking SNORD114-17 to age-related cancer dynamics, although specific evidence for direct involvement of SNORD114-17 in age-related diseases might need further exploration.

### 3. Known Drug Interactions

Currently, there are no specific drugs or drug classes known to have direct interactions with the SNORD114-17 gene at this time. Research into small nucleolar RNAs as therapeutic targets is ongoing, but specific drug associations have not been established.

### 4. Pathways and Biological Processes

- **rRNA Methylation:** As a snoRNA, SNORD114-17 likely participates in guiding the methylation of ribosomal RNA, influencing ribosome biogenesis.
- **Nuclear RNA Processing:** Involvement in the maturation and processing of rRNA, contributing to overall ribosomal function.
- **Gene Expression Regulation:** Plays a role in the regulation of gene expression at the levels of transcription and post-transcriptional modifications.
- **Response to Stress:** While specific pathways for SNORD114-17 might not be explicitly detailed, snoRNAs have been implicated in stress responses, cellular proliferation, and maintenance activities.

### Conclusion

The SNORD114-17 gene represents an interesting component of the ribosomal RNA modification machinery, with potential implications in aging and cellular dynamics. While interactions with specific drugs are not documented, its associations with other snoRNAs and ribosomal biogenesis underline its biological importance in cell function and possibly in the aging process. Further investigation is warranted to fully elucidate the roles of SNORD114-17 in aging and disease.