### Overview of AKT3-IT1 Gene

**Gene Symbol:** AKT3-IT1  
**Gene Type:** Non-coding RNA (lncRNA)  
**Location:** Chromosome 1

AKT3-IT1 is an intronic transcript of the AKT3 gene, which is part of the PI3K/AKT signaling pathway involved in various cellular processes such as metabolism, proliferation, and survival. The exact biological function of AKT3-IT1 is not completely understood, but it is speculated to play a regulatory role in AKT3 expression or activity.

### 1. Associated Genes
While specific associations of AKT3-IT1 with other genes are not extensively documented in the literature, it is likely to have connections to the following:

- **AKT3:** As it is an intron of this gene.
- **PIK3CA:** This gene encodes a catalytic subunit of the PI3-kinase, which works closely with AKT signaling.

Additionally, there may be correlations with other AKT isoforms (AKT1 and AKT2) or genes involved in the PI3K/AKT signaling pathways, such as TSC1, TSC2, and mTOR, but specific associations would need further experimental validation.

### 2. Aging or Age-Related Disease Associations
AKT3 and its related signaling pathways are implicated in various age-related diseases, including:

- **Neurodegenerative Diseases:** Dysregulation of the AKT pathway may contribute to pathologies such as Alzheimer’s disease. The AKT3-IT1 lncRNA may play a role in modulating these pathways.
- **Cancer:** AKT signaling is crucial for cell survival and metabolism and is often dysregulated in cancers that become more prevalent with age.
- **Cardiovascular Diseases:** Changes in AKT pathway signaling have been observed in age-related cardiovascular conditions.

***Note:*** Direct associations of AKT3-IT1 specifically with aging or diseases may need further investigation, as the role of lncRNAs is a new area of research.

### 3. Drug or Drug Classes Interacting with AKT3-IT1
While specific drug interactions for AKT3-IT1 as a lncRNA are not well characterized, the AKT pathway itself is targeted by various therapeutic agents:

- **mTOR Inhibitors** (e.g., Rapamycin): These affect the downstream signaling of the AKT pathway.
- **PIK3CA inhibitors:** Targeting the PI3K/AKT pathway directly impacts downstream AKT signaling.
- **AKT Inhibitors:** Compounds like GSK690693 and MK-2206 specifically inhibit Akt activity.

It is important to note that these interactions are primarily focused on the AKT pathway and not specifically on the lncRNA AKT3-IT1.

### 4. Pathways and Biological Processes
AKT3-IT1 is involved in:

- **PI3K/AKT Signaling Pathway:** This pathway regulates several critical biological processes including cellular growth, metabolism, and survival.
- **Cellular Response to Growth Factor Stimuli:** As part of the feedback mechanisms regulating AKT3 expression, AKT3-IT1 may modulate responses to external growth factors.
- **Cell Proliferation and Survival:** Influencing processes related to apoptosis and cell cycle regulation.

While specific experimental studies focusing on AKT3-IT1 in these pathways are limited, lncRNAs often participate in gene regulatory networks affecting these processes.

### Conclusion
AKT3-IT1 is a long non-coding RNA associated with the AKT3 gene and involved in crucial signaling pathways related to metabolism and growth. Its broader implications in aging and diseases, as well as therapeutic interactions, reflect its potential importance in biomedical research, particularly related to age-associated conditions and cancer. Further research is warranted to elucidate its precise roles and mechanisms.