### NDUFA8P1 Gene Overview

**Gene Symbol**: NDUFA8P1  
**Gene Type**: Pseudogene  
**Location**: NDUFA8P1 is located on chromosome 5. This gene is a pseudogene related to the nuclear-encoded subunits of the mitochondrial enzyme NADH dehydrogenase (complex I). 

### Additional Associated Genes
While there may not be many genes explicitly linked to NDUFA8P1 due to its pseudogenic nature, related genes typically involved in mitochondrial function include:
- **NDUFA8**: The functional homolog of NDUFA8P1, part of the mitochondrial respiratory complex I.
- **NDUFB5**: Another component of mitochondrial complex I.
- Other genes in the mitochondrial electron transport chain may also show associations, given that NDUFA8P1 is tied to complex I functions.

### Aging and Age-Related Diseases
Research into the specific role of NDUFA8P1 in aging or age-related diseases may be limited due to its classification as a pseudogene. However, similar genes involved in mitochondrial function have been implicated in cellular aging and age-related conditions, such as:
- **Mitochondrial dysfunction**: Associated with aging and diseases like Alzheimer's, Parkinson's, and heart disease.
- **Oxidative stress**: Also linked to aging and age-related degenerative diseases, wherein NADH dehydrogenase plays a crucial role in electron transport and reactive oxygen species (ROS) management.

### Drug Interactions
There is currently limited specific information on any drugs directly interacting with NDUFA8P1, primarily because it is a pseudogene and may not be a direct target for pharmacological intervention. However, drugs affecting mitochondrial function, especially those targeting the electron transport chain, may indirectly influence processes related to NDUFA8P1:
- **Mitochondrial Complex I inhibitors**: Such as certain classes of anti-cancer drugs (e.g., rotenone) or neuroprotective agents.

### Pathways and Biological Processes 
NDUFA8P1 itself being a pseudogene may not be directly involved in active biological processes or signaling pathways. However, genes related to it are often part of:
- **Mitochondrial electron transport chain**: Vital for ATP production through oxidative phosphorylation.
- **Metabolic pathways**: Involving energy metabolism and mitochondrial biogenesis.

Given the potential indirect influences through its associated genes, NDUFA8P1 relates to broader processes such as:
- **Cellular respiration**: Impacting overall energy metabolism.
- **Response to oxidative stress**: Which can affect aging and disease.

### Summary
In summary, while NDUFA8P1 as a pseudogene presents limited direct interactions and functions, it is associated with other mitochondrial genes and may reflect broader implications for mitochondrial health, aging, and potential pathways that are relevant to understanding age-related disease mechanisms. Further studies may elucidate more direct roles or implications.