### MMP25-AS1 Gene Overview

**Gene Symbol:** MMP25-AS1  
**Alias:** MMP25 Antisense RNA 1  
**Location:** Human chromosome 20

MMP25-AS1 is an antisense non-coding RNA associated with the MMP25 (Matrix Metallopeptidase 25) gene, which is implicated in the remodeling of extracellular matrix components.

### 1. Associated Genes
MMP25-AS1 is primarily associated with the MMP25 gene, but it may also have interactions or regulatory relationships with other genes involved in extracellular matrix remodeling and tissue remodeling processes. Potentially related genes include:

- **MMP2** (Matrix Metallopeptidase 2)
- **MMP9** (Matrix Metallopeptidase 9)
- **MMP14** (Matrix Metallopeptidase 14)
- **MMP15** (Matrix Metallopeptidase 15)

Other genes involved in pathways of tissue repair, inflammation, and angiogenesis may also show some degree of association.

### 2. Aging and Age-Related Diseases
While specific studies directly linking MMP25-AS1 to aging or age-related diseases are limited, the MMP family of genes is well-known for their roles in extracellular matrix turnover, which influences age-related processes such as:

- Tissue degeneration
- Wound healing efficiency 
- Development of fibrosis
- Cancer metastasis

Altered expression of MMPs has been observed in conditions such as osteoarthritis, cardiovascular diseases, and other degenerative disorders commonly associated with aging.

### 3. Drug Interactions
As MMP25-AS1 is a non-coding RNA, it has no direct drug interactions. However, the MMP25 protein product may interact with various inhibitors and other drug classes targeting matrix metalloproteinases:

- **MMP Inhibitors:** Such as marimastat and batimastat which are primarily investigational drugs known to inhibit matrix metalloproteinases.
- **Anti-inflammatory Drugs:** Some biological processes associated with MMP activity (like inflammation) may be indirectly influenced by corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs).

### 4. Pathways and Biological Processes
MMP25-AS1 is involved in several pathways and biological processes primarily through its association with MMP25 and the larger MMP family:

- **Extracellular Matrix Organization:** Influencing the structure and stability of the extracellular matrix.
- **Tissue Remodeling:** Involved in the remodeling of tissues during normal physiological processes as well as in pathological conditions.
- **Wound Healing:** Facilitating the healing process by regulating the balance between matrix degradation and deposition.
- **Inflammatory Response:** As part of pathways inherently linked to matrix metalloproteinase activity which can modulate inflammation.

### Conclusion
MMP25-AS1 serves as an important regulatory component associated with MMP25, with implications in the remodeling of the extracellular matrix and potentially impacting age-related diseases and other pathological conditions. Further research is warranted to elucidate its precise roles in these processes.