### ALDOC Gene Overview

**Gene Symbol**: ALDOC  
**Location**: The ALDOC gene encodes the aldolase C protein, primarily expressed in specific regions of the brain, particularly the hippocampus and Purkinje cells.

### 1. Associated Genes
While the summary provided does not specify other genes directly associated with ALDOC, it’s notable that:
- ALDOC is part of the aldolase gene family, which includes three key isoforms: 
  - **ALDOA** (aldolase A) in muscle,
  - **ALDOB** (aldolase B) in liver,
  - **ALDOC** (aldolase C) in the brain.
  
Involvement in specific signaling pathways or metabolic pathways may link ALDOC to additional metabolic genes involved in glycolysis, carbohydrate metabolism, and neuronal function.

### 2. Aging and Age-Related Disease Associations
There is growing interest in how metabolic enzymes, including aldolases, may contribute to age-related diseases:
- **Cognitive Decline**: Aldolase C (the protein product of ALDOC) is particularly significant in neuronal function. Changes in its expression or activity may be implicated in cognitive decline and neurodegenerative disorders like Alzheimer’s disease.
- **Metabolic Dysregulation**: Alterations in glycolytic enzymes can lead to metabolic syndrome, a cluster of conditions affecting glucose metabolism that can worsen with age.
- **Neurodegeneration**: Misfolding or dysfunction of metabolic enzymes such as aldolases can contribute to the pathophysiology of age-related neurodegenerative diseases.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly interact with ALDOC are not well documented. However, some points to consider:
- **Metabolic Modulators**: Drugs that affect glucose metabolism could indirectly influence ALDOC activity, as altered metabolic states can influence the expression of metabolic enzymes.
- **Potential Neuroprotective Agents**: Since aldolase C is involved in neuronal metabolism, compounds that boost neuronal health or function could potentially relate back to ALDOC through enhanced glycolytic flux.

### 4. Pathways and Biological Processes
ALDOC is involved in several key biological processes:
- **Glycolysis**: The primary function of aldolase C is in the glycolytic pathway, where it catalyzes the reversible aldol cleavage of fructose-1,6-bisphosphate and fructose 1-phosphate.
- **Carbohydrate Metabolism**: By participating in glycolysis, ALDOC plays a crucial role in the metabolism of carbohydrates, thus influencing energy production in cells, especially in glucose-hungry tissues such as the brain.
- **Neuronal Development and Function**: The expression of aldolase C in specific neurons hints at roles beyond metabolism, potentially influencing neurodevelopment, synaptic plasticity, and overall neuronal health.

Understanding the full implications of ALDOC’s expression and function could provide insights into potential therapeutic targets for metabolic dysregulation or neurodegeneration associated with aging. 

### References for Further Reading
- National Center for Biotechnology Information (NCBI)
- UniProt - Protein Sequence and Functional Information
- Relevant PubMed and scientific literature discussing metabolic enzymes and age-related diseases.