### EFR3A Gene Overview

**Gene Symbol**: EFR3A  
**Chromosomal Location**: Chromosome 17 (specific location can vary based on genome build)  
**Protein Product**: EFR3A protein, a peripheral membrane protein involved in the localization and regulation of phosphatidylinositol 4-kinase (PI4K) at the plasma membrane.

#### 1. Associated Genes
While EFR3A is primarily studied in the context of its role with phosphatidylinositol 4-kinase and GPCR activity, its function may interact with:
- **PI4K** (Phosphatidylinositol 4-kinase): Direct interaction regarding localization and function.
- **GNAQ** and **GNAP**: Genes involved in G-protein signaling, indirectly connected to the GPCR pathways that EFR3A influences.
- **RHOA**: GTPase that may be involved as a downstream effector, though the relationship is complex and not fully understood.
  
#### 2. Age-Related Aspects
Reports suggest that dysregulation of signaling pathways involving EFR3A could relate to neurodevelopmental disorders such as autism, which might have implications in aging, particularly in neurodegenerative conditions. As the population ages, changes in GPCR signaling and phosphatidylinositol metabolism are increasingly recognized in conditions like Alzheimer's Disease, although direct associations with aging are not well documented specifically for EFR3A.

#### 3. Drug Interactions
Currently, there are no widely documented specific drugs or drug classes that directly interact with the EFR3A gene product. However, given its involvement with GPCR signaling:
- **GPCR-targeted therapies**: Drugs that target GPCRs (for example, antipsychotics, antihistamines, and beta-blockers) could theoretically interact with pathways influenced by EFR3A, but this is not a direct interaction.

#### 4. Pathways and Biological Processes
- **Phosphatidylinositol signaling pathway**: EFR3A is involved in the synthesis of phosphatidylinositol 4-phosphate (PtdIns 4P), which is critical for numerous cell signaling cascades.
- **Organization of membrane rafts**: Implicated in cellular processes requiring membrane integrity and function.
- **G-protein coupled receptor signaling**: It plays a role in the modulation of GPCR activity, influencing downstream signaling effects.
- **Cell Growth and Proliferation**: Through its role in lipid signaling, EFR3A may indirectly affect cellular metabolism and proliferation.

### Summary
The EFR3A gene is important for the localization and regulation of phosphatidylinositol 4-kinase, impacting GPCR activity. Although associations with specific age-related conditions or direct drug interactions are not robustly documented, its role in cellular signaling makes it a significant candidate for further study concerning neurodevelopmental and possibly age-related disorders.