**SNORD116-15 Gene Overview**

**Gene Symbol**: SNORD116-15

SNORD116-15 is a C/D box small nucleolar RNA (snoRNA) that is part of the SNORD116 gene cluster located on chromosome 15, particularly in the Prader-Willi syndrome (PWS) critical region. snoRNAs are primarily involved in the modification of other RNA molecules, particularly ribosomal RNA (rRNA), by guiding methylation and pseudouridylation. The function of SNORD116-15 is suggested to be involved in the regulation of pre-mRNA splicing and possibly in the modification of rRNA.

### 1. Associated Genes
While the summaries provided may not list specific associated genes, SNORD116-15 is part of a larger cluster of SNORD116 genes that includes other snoRNAs. Specifically, the **SNORD116** gene cluster encompasses several other snoRNAs, including **SNORD116-1** to **SNORD116-12**. Additionally, genes associated with Prader-Willi Syndrome, such as **SNRPN**, which is involved in imprinting and expression of snoRNA genes, are connected to SNORD116 functionally.

### 2. Aging and Age-Related Diseases
Research into the relationship between SNORD116-15 and aging or age-related diseases is still evolving. However, investigations have suggested that snoRNAs, including SNORD116-15, may have a role in cellular processes linked to aging, particularly through their effects on ribosome biogenesis and RNA processing. Alterations in snoRNA expression have been implicated in neurodegenerative conditions and other age-related disorders, but direct evidence linking SNORD116-15 specifically to aging or age-related diseases is limited.

### 3. Drug Interactions
As of the latest updates, there are no specific drugs or drug classes that are well-documented to directly interact with SNORD116-15. However, given its role in RNA processing and gene regulation, alterations in SNORD116-15 activity may indirectly affect responses to certain therapeutics or modulate pathways relevant to drug metabolism. Further studies may elucidate any pharmacological interactions.

### 4. Pathways and Biological Processes
SNORD116-15 is involved in several biological processes, including:

- **Ribosomal RNA Modification**: As a snoRNA, it is believed to participate in the modification of rRNA, which is essential for ribosome function.
- **RNA Processing**: SNORD116-15 is implicated in the splicing and maturation of pre-mRNAs, influencing gene expression.
- **Prader-Willi Syndrome Pathogenesis**: Given its location within the PWS critical region, alterations in SNORD116-15 and its cluster can affect the expression of genes that contribute to the phenotypic manifestations of PWS.

In conclusion, SNORD116-15 is a small nucleolar RNA that plays a role in RNA processing and modification, with associations to critical developmental disorders and potential links to aging and disease, though further research in these areas is needed for more definitive conclusions.