### FBLN1 Gene Summary

**Gene Name:** FBLN1  
**Gene Symbol:** FBLN1  
**Description:** Fibulin 1 is a secreted glycoprotein that plays a crucial role in extracellular matrix (ECM) structure and function. It is involved in cell adhesion, migration, and organization of the ECM, particularly in basement membranes. FBLN1 can bind to various ECM components, including laminin, fibronectin, and fibrinogen, suggesting its multifunctional role in physiological processes.

### Additional Gene Associations

FBLN1 has been associated with several other genes and proteins in various biological contexts. Beyond the direct interactions mentioned in the summaries, the following are notable associations:

1. **Laminins (LAMA1, LAMB1, LAMC1)** - Laminin family members are integral components of the basement membrane and interact with FBLN1.
2. **Nestin (NES)** - An intermediate filament protein associated with neural stem cells, related to processes where FBLN1 is involved.
3. **Integrins (such as ITGA1, ITGB1)** - Integrins are key players in cell adhesion that could interact with FBLN1 within the ECM.
4. **Nidogen (NID1, NID2)** - Other ECM proteins that may interact or colocalize with fibulin.

### Aging and Age-Related Diseases

While there is limited direct research tying FBLN1 to aging or age-related diseases, a few relevant associations exist:

- **Cancer:** Given its potential role as a tumor suppressor, dysregulation of FBLN1 may contribute to age-related oncogenic transformations.
- **Cardiovascular diseases:** FBLN1's involvement in cell adhesion and thrombosis may associate it with age-related cardiovascular pathologies.
- **Alzheimer's disease:** Given its proposed modulation of the neurotrophic activities of soluble APP, alterations in FBLN1 levels may potentially influence neurodegenerative processes.

### Drug Interactions

While specific drugs targeting FBLN1 are not well-documented, some general categories of drugs that might influence its function include:

- **Anticoagulants:** Given FBLN1’s role in mediating platelet adhesion and incorporating into clots, drugs like aspirin and other anticoagulant medications may indirectly affect its function.
- **Tumor Modulators:** Investigational drugs affecting tumor biology may alter the expression or functionality of FBLN1 within cancer contexts.

### Pathways and Biological Processes

FBLN1 is involved in several important biological processes and signaling pathways, including:

1. **Extracellular Matrix Organization:** FBLN1 contributes to the assembly and architecture of the ECM, which is critical for tissue integrity.
2. **Cell Adhesion and Migration:** It plays a role in processes that drive normal and pathological cell movements.
3. **Wound Healing:** By influencing ECM properties, FBLN1 is involved in tissue repair mechanisms.
4. **Angiogenesis:** Fibulin 1 has implications in the formation of new blood vessels, a critical aspect of development and healing.
5. **Neurotrophic Signaling:** Modulation of neurotrophic factors, potentially influencing neural cell survival and function.

In summary, FBLN1 is a multifaceted gene with significant implications in cell and tissue dynamics, reflecting its importance in development, tumor biology, and possibly aging-related processes. Further research may elucidate its precise roles in these contexts.