### RPL36A Gene Overview

**Gene Symbol:** RPL36A  
**Location:** Human chromosome 1 (1q32.1)   

**Function:** The RPL36A gene encodes a ribosomal protein that is part of the large 60S ribosomal subunit. It plays a critical role in the translation process by contributing to protein synthesis in eukaryotic cells.

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### 1. Associated Genes
While the provided summaries mention the RPL36A gene being related to RPL36AL (ribosomal protein L36a-like), RPL44 is also listed, though it represents a common misnomer for RPL36A. Other potential associated genes include:
- **RPL36AL:** Encodes a protein nearly identical to RPL36A, located in a different gene locus.
- **HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2):** The gene adjacent to RPL36A that exhibits read-through transcription with RPL36A, indicating a functional relationship in ribonucleoprotein activity.

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### 2. Aging and Age-Related Diseases
Although direct studies specifically linking RPL36A to aging or age-related diseases are limited, ribosomal proteins, in general, have been implicated in:
- **Age-related decline in protein synthesis:** Altered expression of ribosomal proteins may lead to a decrease in protein synthesis capacity in aged tissues.
- **Translation control in neurodegenerative diseases:** Dysregulation of ribosomal proteins, including those in the L44E family, has been observed in conditions like Alzheimer's disease and other neurodegenerative disorders, where protein aggregation and synthesis fidelity are crucial factors.
- **Cancer:** Changes in ribosomal protein expression can affect cellular growth and may be linked to cancer pathways.

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### 3. Drug Interactions
Currently, there is no specific drug known to target RPL36A directly. However, certain classes of drugs that impact ribosomal function or protein synthesis may indirectly affect the expression or function of ribosomal proteins, which can include:
- **Antibiotics:** Such as macrolides and aminoglycosides, which inhibit bacterial ribosomes, potentially influencing the regulation of human ribosomal proteins through feedback mechanisms.
- **Chemotherapeutics:** Certain cancer treatments that target rapidly dividing cells can affect the expression of ribosomal proteins and their assembly.

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### 4. Pathways and Biological Processes
RPL36A is involved in various biological processes and pathways, including:
- **Ribosome Biogenesis:** The assembly and maturation of ribosomes, critical for protein synthesis.
- **Translation:** Specifically, the attachment of amino acids to the growing polypeptide chain during protein synthesis.
- **Cell Growth and Proliferation:** Given its role in protein synthesis, RPL36A contributes to the overall growth and maintenance of cellular functions.

Additionally, RPL36A may also be involved in stress response pathways, where ribosome biogenesis is modulated in response to cellular stress, including oxidative stress and nutrient availability.

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### Conclusion
RPL36A is a crucial ribosomal protein involved in protein synthesis, with implications in aging and diseases, particularly due to its association with ribosome function. Further research is warranted to explore potential pharmacological interactions and regulatory mechanisms related to this gene in various biological contexts.