### ZNF365 Gene Overview

**Gene Symbol**: ZNF365  
**Location**: Chromosome 15  
**Function**: The ZNF365 gene encodes a zinc finger protein that plays crucial roles in DNA damage repair, the maintenance of genomic stability, and various neurodevelopmental processes. The protein is particularly noted for its ability to form complexes with other proteins involved in DNA repair, notably PARP1 and MRE11.

### 1. Associated Genes
In addition to PARP1 and MRE11, ZNF365 interacts with several other genes/proteins, including:

- **BRCA1**: Involved in DNA damage repair processes, mutation in this gene leads to increased breast and ovarian cancer risk.
- **TP53**: A critical tumor suppressor gene also involved in maintaining genomic stability and responding to DNA damage.
- **RAD51**: Plays a key role in homologous recombination and DNA repair.
- **MRE11**: Part of the MRN complex which is essential for the maintenance of genomic stability and DNA repair mechanisms.

These interactions highlight ZNF365's broader involvement in maintaining genomic integrity and its associations with cancer biology.

### 2. Aging and Age-related Diseases
ZNF365 has been implicated in the regulation of processes that are critical for maintaining cellular health, which may impact aging and age-related diseases:

- **Cancer Risk**: Mutations in ZNF365 have been linked to an increased susceptibility to breast cancer. Given that the risk of many cancers increases with age, the gene may play a role in the onset of age-related malignancies.
- **Neurodegeneration**: The gene is also involved in neurogenesis and the development of neuronal structures. Dysregulation of these processes is frequently associated with neurodegenerative diseases, which are commonly age-related.

### 3. Drug Interactions
Currently, there are no specific drugs that are widely reported to directly target ZNF365. However, due to its role in DNA repair and genomic stability, it could impact the efficacy of certain cancer therapeutics or be influenced by chemotherapeutic agents that target DNA repair mechanisms:

- **PARP Inhibitors**: Given ZNF365's interaction with PARP1, agents like olaparib and rucaparib, which are PARP inhibitors used in cancer therapy, may indirectly impact ZNF365-related pathways.

### 4. Pathways and Biological Processes
ZNF365 is involved in numerous biological pathways and processes, including:

- **DNA Repair Pathways**: Particularly homologous recombination (HR). ZNF365 assists in the resolution of DNA double-strand breaks and recovery of stalled replication forks.
- **Neurogenesis**: It has a regulatory role in the differentiation of oligodendrocytes and the morphogenesis of neurons, especially during development.
- **Cell Growth and Differentiation**: It is involved in regulating neurite outgrowth and postnatal growth-related differentiation processes.
- **Cellular Responses to Stress**: ZNF365 may play a role in how cells respond to DNA damage and maintain stability in stressed conditions, which is particularly important during aging.

### Summary
ZNF365 is a multifaceted gene essential for genomic stability and various neurological processes. Its implicational role in cancer susceptibility and its involvement in DNA repair mechanisms make it a relevant focus in studies related to aging, neurodegeneration, and cancer biology. Further research continues to elucidate the diverse biological roles of ZNF365 and its potential as a therapeutic target in cancer and age-related diseases.