The RXRB gene, encoding the retinoid X receptor beta, plays a crucial role in mediating the physiological effects of retinoic acid and is integral to various biological processes. Below are additional details based on your request:

### 1. Associated Genes
RXRB has several gene associations that can influence its function or are functionally related, including:
- **RARA (Retinoic Acid Receptor Alpha)**: RXRB forms heterodimers with RARA, which is critical for retinoic acid signaling.
- **RARG (Retinoic Acid Receptor Gamma)**: Similar to RARA, RXRB can form heterodimers with RARG for retinoic acid-mediated signaling.
- **THRA (Thyroid Hormone Receptor Alpha)**: RXRB interacts with THRA for thyroid hormone signaling.
- **VDR (Vitamin D Receptor)**: RXRB also heterodimerizes with VDR, affecting vitamin D regulation.
- **PPARG (Peroxisome Proliferator-Activated Receptor Gamma)**: RXRB may have increased functional interactions with this nuclear receptor.

### 2. Aging and Age-Related Diseases
Research has indicated that RXRB may be implicated in various aspects of aging and age-related conditions:
- Altered retinoic acid signaling, involving RXRB, has been associated with cognitive decline and neurodegenerative diseases, such as Alzheimer's disease.
- RXRB's function in mediating vitamin D signaling may also be relevant, as vitamin D levels are linked to aging processes, including bone density loss and immune function decline.
- Changes in retinoid signaling, mediated by RXRB, have shown potential links to metabolic disorders associated with aging, such as obesity and insulin resistance.

### 3. Drug Interactions
RXRB is targeted by various drugs and compounds due to its role in nuclear hormone receptor signaling:
- **Retinoids**: All-trans retinoic acid and 9-cis retinoic acid are direct ligands that activate RXRB, promoting its role in gene regulation.
- **Thyroid Hormones**: Certain thyroid hormone derivatives may influence RXRB activity indirectly through THRA interactions.
- **Vitamin D Analogues**: Drugs mimicking vitamin D may also engage RXRB due to its heterodimerization with the VDR.
- **Antineoplastic agents**: Some compounds designed for cancer therapy, such as retinoic acid derivatives, directly target RXRB for growth inhibition effects in tumors.

### 4. Pathways and Biological Processes
RXRB is involved in several key biological pathways and processes, including:
- **Retinoid signaling pathway**: A primary pathway that regulates developmental processes, immune responses, and cellular differentiation.
- **Thyroid hormone signaling pathway**: Involved in metabolic regulation, growth, and development.
- **Vitamin D signaling pathway**: Mediating calcium homeostasis and bone metabolism.
- **Cell proliferation and differentiation**: RXRB plays a vital role in various processes related to growth and differentiation, including in embryonic stem cell maintenance and development.
- **Circadian rhythm**: RXRB may also have roles in the regulation of circadian rhythms and metabolic processes influenced by light and dark cycles.

In summary, RXRB is a critical player in nuclear receptor signaling pathways, influencing vital biological functions and potentially contributing to age-related changes and diseases. Its interactions with other nuclear receptors and ligands underline its importance in health and disease.