**PSME3IP1 Gene Overview**

**Gene Symbol:** PSME3IP1  
**Location:** Nucleus  

**Function:** PSME3IP1 is implicated in the negative regulation of proteasomal protein catabolic processes and protein binding activity. Its primary role involves promoting the association of the proteasome activator complex subunit PSME3 with the 20S proteasome, thereby regulating the proteolytic activity of the proteasome. Additionally, it inhibits PSME3-mediated degradation of certain proteasome substrates, potentially by modifying their diffusion rate into the catalytic chamber of the proteasome. PSME3IP1 may also restrict the interaction of PSME3 with COIL, influence the accumulation of PSME3 in Cajal bodies, and regulate the overall number of Cajal bodies in the nucleus.

### 1. Associated Genes
While specific literature may be required to identify all associated genes, some other genes involved with PSME3IP1 include:

- **PSME3**: This gene encodes the proteasome activator complex subunit, which is a direct partner of PSME3IP1.
- **COIL (Cajal body specific protein)**: This gene is involved in the formation and maintenance of Cajal bodies.

### 2. Aging and Age-Related Diseases
Current research does not provide a direct and unequivocal link between PSME3IP1 and aging or age-related diseases. However, the proteasome's role in protein degradation and the maintenance of cellular proteostasis is crucial for cell health. Dysregulation in proteasomal function is often implicated in age-related diseases, such as neurodegenerative disorders. Therefore, while PSME3IP1's specific role in aging is not explicitly documented, its influence on proteasomal activity suggests it could be relevant in context to age-related pathologies.

### 3. Drug Interactions
Information on specific drugs or drug classes interacting with PSME3IP1 is limited. However, since PSME3IP1 influences proteasomal activity, compounds that modulate proteasome function (such as proteasome inhibitors like Bortezomib) may have indirect effects on PSME3IP1 activity. Further studies could elucidate more precise interactions.

### 4. Pathways and Biological Processes
PSME3IP1 is involved in several biological processes and pathways, notably:

- **Proteasomal protein catabolic process**: It plays a critical role in the regulation of protein degradation within the proteasome.
- **Regulation of protein binding**: It is involved in modulating interactions between proteins, particularly those associated with the proteasome and its substrates.
- **Cajal body dynamics**: PSME3IP1 impacts the formation and number of Cajal bodies, contributing to nuclear organization and RNA metabolism.

Research into further cellular and molecular pathways involving PSME3IP1 could provide additional insights into its functions and regulatory roles. 

For detailed interactions, databases such as Pathway Commons, Reactome, or KEGG could also be explored for quantitative data.