### RCOR3 Gene Overview

**Gene Symbol:** RCOR3 (Rest Corepressor 3)  
**Location:** Cytosol and nucleoplasm  

RCOR3 is a gene that encodes a protein involved in transcriptional regulation, specifically functioning as a transcriptional corepressor. The protein is predicted to have enzyme binding activity and plays a role in the regulation of transcription by RNA polymerase II. Additionally, it is linked with histone deacetylation and the negative regulation of transcription in a DNA-templated manner.

### 1. Associated Genes

RCOR3 interacts with several other genes and proteins, particularly those involved in transcription regulation. Some of the known interacting partners include:

- **REST (RE1-Silencing Transcription Factor):** The primary related gene, REST, is critical in neuronal development and regulates a variety of genes, helping to establish neuronal identity.
- **CoREST (Co-repressor of REST):** RCOR3 may mediate the effects of REST and interacts with the CoREST complex.
- **HDACs (Histone Deacetylases):** RCOR3 is associated with various HDACs, which are critical for histone modifications and transcription repression.

### 2. Aging and Age-related Diseases

There is limited direct evidence linking RCOR3 with aging or specific age-related diseases; however, its role in transcriptional regulation and histone deacetylation suggests potential implications in cellular aging processes. Alterations in transcriptional regulation mechanisms are often observed in age-related diseases. 

Research has suggested that:

- **Neurodegenerative Diseases:** Given its association with REST and neuronal functions, dysregulation of RCOR3 may influence the progression of neurodegenerative diseases such as Alzheimer’s disease, where transcriptional dysregulation is a prominent feature.
- **Cancer:** RCOR3's regulatory role may play a part in oncogenesis, where aberrant transcriptional regulation is a hallmark of cancer.

### 3. Drug Interactions

As of the latest data in October 2023, specific drugs or drug classes directly targeting RCOR3 are not well-documented. However, given its role in histone deacetylation and transcription suppression, compounds that affect histone deacetylases (HDACs), such as:

- **HDAC inhibitors (e.g., Vorinostat, Romidepsin)**: These drugs are used in cancer therapy and may indirectly influence the activity of RCOR3 by altering the broader histone modification landscape.
  
### 4. Pathways and Biological Processes

RCOR3 is implicated in several biological processes and pathways, including:

- **Histone Modification:** As a component of a complex that regulates histone deacetylation, RCOR3 plays a role in modifying chromatin structure, thus influencing gene expression.
- **Transcription Regulation:** RCOR3 participates in negative transcription regulation, particularly in RNA polymerase II-promoter interactions.
- **Developmental Biology:** It is suggested to play a role in neuronal differentiation and function, likely through its interaction with REST.

### Conclusion

RCOR3 is a critical gene involved in the regulation of transcription through its corepressor activity and interactions with other proteins involved in histone modification. While direct links to aging and specific drug interactions are still being investigated, its role in transcriptional repression suggests potential implications in both neurodegenerative disorders and cancer. Further research is needed to elucidate its complete role in aging and disease mechanisms.