### APC2 Gene Overview

**Gene Symbol**: APC2  
**Location**: The APC2 gene is located on chromosome 3 in humans.

#### 1. Associated Genes
While the NCBI and UniProt summaries primarily focus on **beta-catenin (CTNNB1)** and the APC tumor-suppressor protein, other genes that APC2 may be associated with include:

- **GSK3B (Glycogen synthase kinase 3 beta)**: Involved in the Wnt signaling pathway and regulates the phosphorylation of beta-catenin.
- **AXIN1 (Axis inhibition protein 1)**: A core component of the destruction complex that degrades beta-catenin.
- **APC (Adenomatous polyposis coli)**: Although this gene is a different gene from APC2, it is functionally related and important in colorectal cancer progression.
- **RHOA (Ras homolog family member A)**: Interacts with cytoskeletal mechanisms and may intersect with APC2’s regulation of actin dynamics.

#### 2. Aging and Age-related Diseases
While specific studies directly linking the APC2 gene to aging are limited, its role in cellular processes can be extrapolated:

- **Tumorigenesis**: APC2’s involvement in beta-catenin degradation links it to cancer genetics. Age-related increase in cancer risk (cancer is linked to aging) could be influenced by malfunctions in this pathway, suggesting that APC2 may play an indirect role in age-related tumorigenesis.
- **Neurodegeneration**: Given its expression in the central nervous system and potential involvement in neuronal function, altered APC2 function could relate to neurodegenerative disorders, which have a strong age component (e.g., Alzheimer's disease).
- **Regulation of Cell Adhesion**: As cellular adhesion plays a role in tissue integrity and function, any dysregulation may also relate to age-related decline in tissue regeneration and repair.

#### 3. Drug Interactions
APC2 itself is not directly targeted by specific drugs, but due to its role in the Wnt signaling pathway and cell signaling, studies explore interactions with:

- **Wnt Pathway Inhibitors**: While not drugs targeting APC2, modulators of the Wnt pathway (e.g., ICRT-3) could influence the pathway where APC2 is critically involved.
- **Proteasome Inhibitors**: Since APC2 promotes the degradation of beta-catenin via the proteasome, drugs in this class might indirectly affect its function in tumor suppression.

Assigning drugs or drug classes solely to APC2 remains under exploration, and further studies are warranted to characterize drug-gene interactions more definitively.

#### 4. Pathways and Biological Processes
APC2 is involved in several critical biological pathways and processes:

- **Wnt Signaling Pathway**: Crucial for regulating gene expression related to development and cancer suppression.
- **Cellular Component Organization**: Facilitates organization and dynamics of the cytoskeleton, particularly related to actin and microtubules.
- **Neurodevelopment**: Involved in CNS development and potentially in maintaining neuronal health through cytoskeletal stabilization.
- **Ubiquitin-mediated Proteolysis**: Plays a role in the targeting of beta-catenin for degradation, modulating proteolytic pathways critical for cell signaling.

### Summary
The APC2 gene not only serves a pivotal role in regulating Wnt signaling and beta-catenin amounts but also participates in cellular structure and CNS development. Further investigations into its roles in aging and neurodegenerative diseases, as well as drug interactions, will enhance understanding of its contributions to health and disease.