### NUP98 Gene Summary

**Gene Symbol:** NUP98  
**Location:** Chromosome 11p15.5  
**Function:** The NUP98 gene encodes a nucleoporin that is part of the nuclear pore complex (NPC), which regulates the transport of macromolecules between the nucleus and cytoplasm. The protein product participates in various cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The gene also undergoes autoproteolytic cleavage to produce two distinct nucleoporins (98 kDa and 96 kDa).

### Additional Associated Genes
Apart from the nucleoporins, NUP98 has been associated with various genes in the context of translocations that are involved in leukemias. Notably:
- **NUP96:** As indicated in the summaries, it is directly involved with NUP98 in the NPC.
- **AF4/FMR2 family members:** Such as **AF4**, which are often among the partner genes in translocations associated with hematopoietic malignancies.
- **PBX1:** Another gene that has shown fusion events with NUP98 in acute myeloid leukemia (AML).
- **RUXF1 (also known as RANBP2):** Involved in fusions leading to leukemias.
- **SET:** Known to interact with NUP98 in fusion proteins associated with acute leukemias.

### Aging and Age-Related Diseases
- **Aging:** While there are no direct studies establishing a significant link between NUP98 and aging, nucleoporins, including NUP98, play essential roles in maintaining cellular homeostasis and nucleocytoplasmic transport. Disruption of these processes has been associated with age-related decline in cellular function.
- **Age-Related Diseases:** NUP98 rearrangements (particularly via translocations) are prevalent in acute myeloid leukaemia (AML) and other hematologic cancers, which are diseases with an increased incidence in aging populations.

### Drug Interactions
Currently, specific drugs that directly target NUP98 are not well-characterized, but the following points are noteworthy:
- **Antineoplastic Agents:** Certain chemotherapy drugs may impact the pathways involving nucleoporins indirectly through cellular stress responses. 
- **Targeted Therapies:** Drugs that target fusion proteins stemming from NUP98-related translocations are under investigation. The compounds being developed are often directed at the fusion partner proteins (such as **FLT3 inhibitors**) in contexts of AML.

### Pathways and Biological Processes
NUP98 is involved in various biological pathways and processes, including:
- **Roles in Nuclear Transport:** Participates in the nuclear pore complex assembly and maintenance, facilitating bidirectional transport across the nuclear envelope.
- **Gene Expression Regulation:** The protein, through its interaction with DHX9, affects transcription and alternative splicing of specific genes.
- **Mitotic Progression:** Involvement in cell cycle control and mitotic progression.
- **Apoptosis and Cell Cycle Regulation:** It contributes to overall cellular inducement of apoptosis and cell cycle checkpoints.
- **Developmental Processes:** Involvement in processes related to embryonic development and differentiation.

### Summary
The NUP98 gene plays a critical role in cellular transport processes and has significant implications in hematologic malignancies through its fusion with other gene partners. Though research specific to aging is limited, NUP98’s role in general cellular integrity makes it an important factor in age-related physiology. Its connectivity to certain pathways and processes underlines its relevance in various biological functions and disease mechanisms. Further research may elucidate more specific implications of NUP98 across different biological contexts.