### KLHDC3 Gene Overview

**Gene Symbol:** KLHDC3

**Function:** The KLHDC3 gene encodes a protein that contains six repeated kelch motifs, suggesting a role in protein-protein interactions. This protein is part of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which is involved in recognizing and targeting specific proteins for ubiquitination and subsequent degradation via the proteasome. 

**Expression:** The KLHDC3 gene is specifically expressed in the testis, particularly in pachytene spermatocytes, and its expression is localized in the cytoplasm and meiotic chromatin. This suggests a role in meiotic recombination and potentially in sperm development.

### Additional Details

1. **Associated Genes:**
   - While the summaries provided focus on KLHDC3's ubiquitination role and its specific interactions, it is likely associated with other genes involved in meiosis and the ubiquitin-proteasome system. However, detailed associations may not be well characterized. Some candidates for associated genes in the context of meiotic processes might include those involved in chromosomal segregation during meiosis (e.g., genes coding for cohesins or other meiotic splicing factors). Specific genes directly linked to KLHDC3 through detailed functional studies might need literature review or database exploration.

2. **Aging and Age-Related Diseases:**
   - There is limited direct information relating KLHDC3 to aging or age-related diseases in the available literature. However, as it is involved in the meiotic process, it may have indirect implications for reproductive aging or infertility, which often becomes a concern with advancing age. Additionally, since aberrations in the ubiquitin-proteasome system can contribute to various age-related disorders, KLHDC3 might have links to cellular senescence and related pathways, though this remains an area requiring further research.

3. **Drugs/Drug Classes Interaction:**
   - As of the latest knowledge cutoff in October 2023, there are no specific drugs or drug classes explicitly known to interact with KLHDC3. Nonetheless, compounds targeting the ubiquitination pathway or proteasome inhibitors might indirectly affect KLHDC3's functional pathways. Again, a thorough verification through drug interaction databases or current literature could provide updated information.

4. **Pathways and Biological Processes:**
   - KLHDC3 is involved in:
     - **Meiotic recombination**: The gene's expression in testis, particularly during meiosis, suggests its function in recombination processes.
     - **Protein ubiquitination**: It is part of the CRL2 E3 ubiquitin ligase complex, involved in post-translational modification and regulation of protein levels, particularly targeting proteins for degradation based on degradation motifs (degrons).
     - **Spermatogenesis**: Given its testis-specific expression, KLHDC3 is likely essential for normal sperm development. 

**Note:** For the latest research and deeper insights, continuous exploration of genomic databases, current literature, and biological pathways related to KLHDC3 is encouraged, especially given the ongoing advances in understanding gene functions and their implications in health and disease.