### TAGLN3 Gene Overview

**Gene Symbol:** TAGLN3 (Transgelin 3)

#### General Information:
The TAGLN3 gene is predicted to be involved in the development of the central nervous system. It is associated with the negative regulation of transcription by RNA polymerase II, suggesting a role in gene expression regulation. Additionally, TAGLN3 is anticipated to be located in the nucleus and is active in the cytoskeleton, indicating a possible role in cytoskeletal dynamics.

#### Expression Profile:
TAGLN3 is widely expressed in the brain, with increased expression noted in the superior frontal cortex of individuals with a history of alcoholism, while expression levels in the motor cortex and cerebellum remain unchanged.

### Additional Information:

1. **Associated Genes:**
   - While specific gene associations may not be detailed in summarized sources, genes involved in cytoskeletal dynamics (like ACTN family, which encodes for actin-binding proteins), and genes implicated in synaptic plasticity (like CAMKII, a calcium/calmodulin-dependent protein kinase) could be presumed associated based on functional overlapping in neuroscience and cytoskeletal roles. Any direct known interactions or co-expressions typically involve bioinformatics platforms or experimental data not summarized here.

2. **Aging and Age-Related Diseases:**
   - While direct associations between TAGLN3 and aging or specific age-related diseases have not been documented in the provided summaries, altered expression of cytoskeletal proteins has been linked to neurodegenerative diseases (like Alzheimer's disease). Elevated TAGLN3 in response to chronic alcohol exposure may imply neuroadaptive changes relevant to addiction and perhaps age-related cognitive decline.

3. **Drug Interactions:**
   - No specific drugs or drug classes are mentioned in the summarized sources. However, because TAGLN3 expression is altered in the context of alcoholism, it may be indirectly linked to substances affecting neurotransmission or cytoskeletal integrity, e.g., chronic use of alcohol and the resulting neuroadaptive changes. Detailed interactions may require specific drug screening studies or literature searches.

4. **Pathways and Biological Processes:**
   - TAGLN3 is suggested to play a role in:
     - **Cytoskeleton Organization:** Contributing to the structural integrity and signaling pathways within cells.
     - **Regulation of Gene Expression:** Engaged in pathways involving transcription regulation.
     - **Nervous System Development:** Involved in processes related to neural differentiation and proliferation.
     - Potentially implicated in pathways contributing to neuronal injury and recovery since altered cytoskeletal dynamics are significant factors in neuronal health.

### Summary
Overall, TAGLN3 appears to be a pivotal gene in central nervous system development and functioning, with expression dynamics that implicate its role in neurobiology and possibly in responses to neurological insults such as alcohol use. Further research may elucidate its involvement in aging and neurodegenerative processes, as well as any therapeutic implications.