### Overview of SNORD116-28

**Gene Symbol:** SNORD116-28  
**Gene Type:** Non-coding RNA (snoRNA)  
**Location:** Human chromosome 15 (15q11.2)  
**Function:** SNORD116-28 is part of the SNORD116 (also referred to as C/D box small nucleolar RNA) family, which is known for its role in the modification of ribosomal RNA (rRNA). snoRNAs are involved in the methylation and pseudouridylation of rRNA, which are crucial for ribosome biogenesis and function.

### 1. Associated Genes
While specific associations may not be widely documented, the SNORD116 gene cluster, which includes SNORD116-28, is associated with several other snoRNA genes within the imprinted domain on chromosome 15. These include:
- SNORD116-1
- SNORD116-2
- SNORD116-3
- Other members of the SNORD116 gene family.

Furthermore, because SNORD116 is linked to maternal imprinting, it has implications in genetic scenarios where parental gene expression is of significance.

### 2. Aging and Age-Related Diseases
- **Role in Prader-Willi Syndrome (PWS):** SNORD116-28 is associated with Prader-Willi syndrome, a condition characterized by obesity, intellectual disabilities, and other metabolic issues. This condition arises from the loss of function of genes within the paternal allele of the 15q11-q13 region, which includes the SNORD116 gene cluster. Although not directly linked to aging, the metabolic dysregulations resulting from PWS may exhibit age-related manifestations.
- **Gene Expression Changes with Aging:** There is some evidence suggesting that snoRNA expression, including members of the SNORD116 family, may change with age, impacting ribosomal synthesis and overall cellular function, although this is an area that requires more direct research.

### 3. Drug Interactions
As of the last available data, there are no specific drugs or drug classes known to interact directly with SNORD116-28. However, given its role in the cellular machinery that produces rRNA, any drugs that affect ribosome biogenesis may indirectly influence its effects. It is advisable to consult further detailed databases or experimental data for any updates on drug interactions.

### 4. Pathways and Biological Processes
SNORD116-28 is involved in several biological processes, primarily related to:
- **Ribosome Biogenesis:** By guiding the modification (methylation, pseudouridylation) of rRNA, thus ensuring proper ribosomal function.
- **Gene Expression Regulation:** Involved in the regulation of rRNA levels and hence indirectly influencing protein synthesis.
- **Cellular Growth and Proliferation:** Effective ribosome function is critical for cellular growth processes, linking snoRNA function to broader biological pathways.

### Conclusion
SNORD116-28, as part of the larger SNORD116 family, plays a fundamental role in the modification of rRNA, influencing ribosome biogenesis and cellular function. Its association with Prader-Willi syndrome highlights its clinical relevance, particularly in the context of metabolic disorders. Further research will elucidate more about its roles in aging and disease.