### FBXO44 Gene Overview

**Gene Symbol**: FBXO44  
**Gene Family**: F-box protein family  
**Function**: Encodes a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, involved in phosphorylation-dependent ubiquitination.

### 1. Associated Genes
FBXO44 is associated with several other genes, particularly those involved in ubiquitination and the degradation pathway. While the provided summaries focus on certain family members, the following genes may also be relevant:
- **SKP1**: This gene encodes a component of the SCF complex crucial for transferring ubiquitin.
- **CUL1**: Another component of the SCF ubiquitin ligase complex.
- **FBXO2 and FBXO6**: Other members of the F-box family that may share functional similarities or pathways with FBXO44.

### 2. Aging and Age-Related Diseases
- **Aging**: Ubiquitination processes mediated by FBXO44 may play a role in cellular aging, as defective protein homeostasis can accumulate damaged proteins over time, a hallmark of aging.
- **Age-Related Diseases**: While specific studies linking FBXO44 directly with age-related diseases are limited, research on F-box proteins in general indicates possible implications in neurodegenerative diseases and cancer. Dysregulation of ubiquitin-proteasome pathways has been associated with these conditions, possibly implicating FBXO44 in their pathogenesis.

### 3. Drug Interactions
As of October 2023, specific drug interactions directly targeting FBXO44 may not be extensively characterized. However, compounds that affect the ubiquitin-proteasome system or E3 ubiquitin ligases more generally may influence FBXO44 function. Classes of drugs of interest could include:
- **Proteasome inhibitors** (e.g., Bortezomib)
- **MLN9708** (an investigational drug targeting proteasomes)
- Studies exploring the modulation of F-box proteins in cancer therapies might also shed light on potential interactions or drugs targeting this gene indirectly.

### 4. Pathways and Biological Processes
FBXO44 is involved in various biological processes and pathways, including:
- **Ubiquitin-mediated proteolysis**: Integral to protein degradation and turnover within the cell.
- **Cell cycle regulation**: It may be involved in regulating protein levels of cell cycle control proteins.
- **Response to DNA damage**: Substrates of FBXO44 may include proteins that respond to DNA damage, contributing to cellular stress responses.
- **Neural development**: Given its membership in the NFB42 family, FBXO44 may have roles in neurogenesis or neural function.

### Summary
FBXO44 encodes a member of the F-box protein family involved in the SCF E3 ubiquitin ligase complex, with potential implications in aging, age-related diseases, and various biological pathways, particularly those related to protein ubiquitylation and degradation. Further research is needed to delineate specific drug interactions and the gene's role in pathophysiological conditions.