### KLHL17 Gene Overview
**Gene Symbol:** KLHL17  
**Location:** Chromosome 3 (3q26.2)  
**Protein Structure:** The KLHL17 gene encodes a protein containing two distinct functional domains: an N-terminal BTB domain and a C-terminal Kelch domain. The BTB domain is crucial for dimerization and interaction with other proteins, while the Kelch domain is involved in binding to actin filaments (F-actin), implicating KLHL17 in actin-based processes, especially in neurons.

### 1. Associated Genes
KLHL17 has been implicated in a variety of regulatory pathways and may show functional associations with other genes involved in neuronal function and actin dynamics. While specific genes are not explicitly mentioned in the summaries, potential associations include:
- **GLUR6 (Gria6)**: The KLHL17 protein is known to mediate the ubiquitination and degradation of the GLUR6 glutamate receptor, linking it indirectly to synaptic function and plasticity.
- **CUL3**: As a part of the BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, it may interact with other substrate proteins that are regulated by this complex.

### 2. Aging and Age-Related Diseases
Currently, there is limited specific information directly linking KLHL17 to aging or age-related diseases. However, considering its role in neuronal function and actin dynamics, alterations in KLHL17 function could potentially influence neurodegenerative diseases or age-related synaptic dysfunction. Dysregulation of neuronal proteins, including receptors like GLUR6, has been associated with conditions such as Alzheimer's disease and frontotemporal dementia.

### 3. Drug Interactions
While there is no specific information indicating direct drug interactions with KLHL17 in the current literature, the pathways that KLHL17 influences — related to synaptic transmission and actin dynamics — could theoretically be modulated by drugs targeting neurotransmitter receptors or actin polymerization. Potential indirect connections to drugs might include:
- **Antidepressants**: Since KLHL17 is linked to glutamate signaling, modulators of glutamatergic transmission may influence its activity.
- **Neuroprotective agents**: Compounds that stabilize actin dynamics may also interact with the pathways influenced by KLHL17.

### 4. Pathways and Biological Processes
KLHL17 is known to be involved in several important cellular processes and pathways:
- **Actin Cytoskeleton Organization**: The actin-binding capacity of KLHL17 implicates it in cytoskeletal rearrangements essential for neuronal growth and function. 
- **Ubiquitin-Proteasome System**: As a component of E3 ubiquitin ligase complexes, KLHL17 is involved in protein ubiquitination and subsequent degradation, playing a critical regulatory role in protein homeostasis within the cell.
- **Neuronal Development and Function**: Its expression in neurons suggests a crucial role in synaptic transmission and neuronal architecture, thereby contributing to learning and memory processes.

In summary, KLHL17 is a significant gene with important roles in neuronal function and actin dynamics. Its involvement in various pathways underlines its potential relevance to both normal physiology and pathological processes, particularly in the aging nervous system.