### VPS35L Gene Overview

**Gene Symbol**: VPS35L  
**Location**: Endosome  
**Function**: VPS35L is a key player in intracellular transport, specifically involved in Golgi to plasma membrane transport and endocytic recycling. It is an essential component of the retriever complex, which is crucial for retromer-independent retrieval and recycling of various cargo proteins, including integrins and proteins with the NxxY motif that assist in maintaining the homeostasis of cell surface proteins.

---

### 1. Associated Genes
While the provided summaries do not explicitly mention other genes, VPS35L may be associated with genes involved in similar pathways or complexes:
- **SNX17**: A key cargo protein essential for the retrieval of proteins from endosomes.
- **ITGA5** and **ITGB1**: Integrin components that are part of the cargo that VPS35L helps to recycle.
- **CCC Complex Proteins**: Various members contributing to the cargo retrieval mechanisms.
- **WASH Complex Proteins**: Members of this complex are involved in the recruitment of the retriever complex to endosomal membranes.

### 2. Aging and Age-Related Diseases
There currently exist limited direct associations of VPS35L with aging or specific age-related diseases; however, the following are inferred based on its functions:
- **Cell Surface Protein Homeostasis**: Disruption in the recycling of cell surface proteins could have implications in age-related cellular senescence and reduced cellular responsiveness, impacting overall physiological functions.
- **Copper Metabolism**: Alterations in ATP7A trafficking, a process potentially regulated by VPS35L, can affect copper homeostasis, as copper-related dysregulation has been linked to age-related neurodegenerative diseases (e.g., Wilson's disease, Alzheimer's disease).

### 3. Drug or Drug Classes Interacting with VPS35L
As of the latest available data (up to October 2023), there are no well-documented drugs specifically targeting the VPS35L gene or its protein product. However, broad classes of compounds, such as:
- **Inhibitors of endocytic pathways**: These might indirectly affect VPS35L function by influencing its associated complexes or cargo activities.

### 4. Pathways and Biological Processes
VPS35L is involved in several crucial biological pathways:
- **Endocytosis**: Plays a role in the intracellular transport processes by mediating the retrieval of cargo from endosomes to the trans-Golgi network.
- **Protein Recycling**: Essential for the recycling of integral membrane proteins involved in various cellular processes (migration, adhesion, signaling).
- **Copper Ion Transport**: Involvement in the regulatory pathway for copper-dependent protein transport.

VPS35L participates in the following biological processes:
- Endosomal membrane transport.
- Regulation of cell surface protein levels.
- Interaction with cytoskeletal elements through complexes like WASH and CCC, contributing to cellular structure and signaling.

---

In summary, VPS35L is an integral gene in intracellular transport and recycling mechanisms. Its role extends to essential pathways that ensure cellular homeostasis, with potential implications in age-related cellular changes and diseases, though further direct links may require additional research.