### PPP6R2 Gene Overview

**Gene Symbol**: PPP6R2  
**Gene Description**: The PPP6R2 gene encodes a regulatory subunit of protein phosphatase 6 (PP6), which plays a critical role in various cellular processes including cell cycle regulation and signal transduction. The encoded protein is a significant T-loop phosphatase for Aurora A, a key kinase involved in mitosis. Mutations or loss of function in PPP6R2 can disrupt normal spindle formation and chromosome alignment, essential during cell division.

### 1. Associated Genes
In addition to the proteins directly interacting with PPP6R2, additional genes implicated in related pathways include:

- **AURKA (Aurora Kinase A)**: Directly interacts with the phosphatase activity of PPP6R2.
- **PPP6C (Protein Phosphatase 6 Catalytic Subunit)**: The catalytic subunit of PP6, forming a complex with PPP6R2.
- **NFKBIE (IκB epsilon)**: A substrate of the PP6 complex that is dephosphorylated in the presence of PPP6R2.
- **BRAF**: Involved in signaling pathways regulated by PPP6R2.
- **PTEN**: Plays a role in cell cycle and apoptosis pathways affected by the regulation of PP6.

### 2. Aging and Age-Related Diseases
Though specific studies directly linking PPP6R2 to aging or age-related diseases are limited, its involvement in the regulation of cell division and signal transduction suggests a potential role. Dysregulation of cell cycle checkpoints and mitotic processes can lead to cellular senescence, a characteristic of aging. Furthermore, aberrant PPP6R2 activity might play a role in the development of cancer due to its involvement in chromosome alignment and spindle formation. A potential association with conditions such as:

- **Cancer**: Due to its role in chromosomal stability and mitosis.
- **Neurodegenerative Diseases**: Given that proper cell signaling is essential for neuron health.
  
Future research may elucidate more precise connections between PPP6R2 and specific age-related pathologies.

### 3. Drug Interactions
Research has not specified direct drug interactions with PPP6R2. However, different classes of drugs which affect pathways involving PP6, Aurora kinases, or NF-kB signaling may indirectly influence the activity of PPP6R2. Classes to consider include:

- **Aurora Kinase Inhibitors**: Such as Alisertib, which may impact pathways involving PPP6R2.
- **Corticosteroids/Immunosuppressants**: They can affect NF-kB pathways indirectly moderated by PPP6R2 through NFKBIE dephosphorylation.

Additional research is needed to better characterize direct pharmacological interactions.

### 4. Pathways and Biological Processes
PPP6R2 is involved in several critical biological pathways:

- **Cell Division and mitosis**: Acts as a facilitator of spindle assembly through dephosphorylation of Aurora A.
- **Signal Transduction**: Intersecting pathways like NF-kB signaling, as it regulates the degradation of IκB proteins.
- **Regulation of Apoptosis and Survival**: Involvement in cellular survival pathways via NFKBIE modulation.
- **Reactive Oxygen Species (ROS) Regulation**: PPP6R2 may play roles in oxidative stress response through phosphatase activity, contributing to cellular response to metabolic demands and external stressors.

In summary, the PPP6R2 gene encodes an important regulatory subunit of Protein Phosphatase 6, with significant roles in cell cycle regulation and signal transduction that could influence related pathologies, including cancer and potentially neurodegenerative diseases. Further research may deepen our understanding of its full implications in aging and therapeutic interventions.