### CBR3-AS1 Gene Overview

**Gene Symbol:** CBR3-AS1  
**Location:** CBR3-AS1 is located on chromosome 21. It is an anti-sense long non-coding RNA (lncRNA) associated with the CBR3 gene, which encodes the enzyme carbonyl reductase 3.

### 1. Associated Genes
There are a few known genes associated with CBR3-AS1, particularly in the context of its regulatory role over the CBR3 gene. Additionally, research has indicated potential associations with genes involved in metabolic processes and disease pathways, but specific gene associations beyond CBR3 may vary across studies. For example, interactions with the following genes have been noted in various contexts:
- **CBR3** - The protein coding gene directly regulated by CBR3-AS1.
- **ABCB1** (ATP-binding cassette sub-family B member 1) - While not directly regulated, its expression levels may be influenced by regulatory RNAs in the vicinity.

### 2. Aging and Age-Related Diseases
Research suggests that alterations in lncRNA expressions, including CBR3-AS1, may be associated with various age-related diseases, including:
- **Cancer:** Aberrant expression levels of lncRNAs like CBR3-AS1 have been implicated in various tumors. In older individuals, dysregulation could lead to changes in cellular metabolism and proliferation.
- **Cardiovascular Diseases:** The involvement of lncRNAs, particularly in cardiovascular pathology, has been documented, and age-related heart failure often features altered lncRNA expression profiles.

### 3. Drug Interactions
Currently, specific drug interactions with CBR3-AS1 itself have not been extensively characterized. However, because CBR3 is involved in drug metabolism and bioactivation of several compounds, lncRNAs like CBR3-AS1 could play indirect roles in influencing drug efficacy and toxicity. Here are a few notable drug classes related to CBR3, where CBR3-AS1 might have an indirect impact:
- **Antineoplastic agents**: As CBR3 is involved in the metabolism of chemotherapeutic agents.
- **Nonsteroidal anti-inflammatory drugs (NSAIDs)**: CBR3 may impact the effectiveness of NSAIDs through metabolism.

### 4. Pathways and Biological Processes
CBR3-AS1 is involved in various biological processes and pathways, including:
- **Gene Regulation:** As a long non-coding RNA, CBR3-AS1 plays a crucial role in the transcriptional and post-transcriptional regulation of the CBR3 gene and possibly other related genes.
- **Metabolic Processes:** It may influence the metabolism of carbonyl compounds due to its association with CBR3.
- **Cell Proliferation and Apoptosis:** The regulatory role of CBR3-AS1 could affect processes tied to cell cycle and apoptosis, which are critical in cancer progression, especially in aging populations.

### Summary
CBR3-AS1 is a long non-coding RNA involved in regulating the CBR3 gene and potentially influencing related metabolic pathways. It may play a role in age-related diseases like cancer and cardiovascular conditions, although direct connections to specific drugs or drug classes are currently less well-characterized. Further research is warranted to deepen understanding of its biological significance.