### SKOR1 Gene Summary

**Gene Symbol:** SKOR1  
**Function:** The SKOR1 gene encodes a protein that enables SMAD binding activity and has sequence-specific double-stranded DNA binding activity. It is involved in the negative regulation of the BMP (Bone Morphogenetic Protein) signaling pathway and acts as a transcriptional corepressor of LBX1. The gene's expression is localized in dendrites and neuronal cell bodies.

### Additional Associated Genes

While the NCBI and UniProt summaries focus on specific functions and interactions, research has shown that SKOR1 might also be associated with several other genes and factors involved in neuronal function and signaling pathways, although detailed connectivity may require further literature validation. Genes commonly studied alongside SKOR1 include:

- **LBX1:** As mentioned, SKOR1 acts as a corepressor of LBX1.
- **SMAD family genes (SMAD1, SMAD5, SMAD9):** These are downstream effectors in the BMP signaling pathway that could be impacted by SKOR1 activity.

### Aging and Age-related Diseases

Research on the role of SKOR1 in aging is sparse. However, since it functions in neuronal signaling and development, disturbances in BMP signaling pathways have been linked to neurodegenerative diseases, as well as age-related decline in neural function. Persistent dysregulation of these pathways in aging may contribute to conditions like Alzheimer's disease or other forms of dementia.

### Drug Interactions

Currently, there are no specific drugs listed that directly interact with SKOR1. However, since SKOR1 is implicated in BMP signaling, it's possible that compounds that modulate BMP pathways, including small molecule inhibitors or pathway modulators, could have indirect interactions and effects related to SKOR1 activity. This aspect should be explored with further investigations focusing on drug discovery linked to BMP signaling.

### Pathways and Biological Processes

SKOR1 plays a role in several key biological processes and signaling pathways, including:

- **BMP signaling pathway:** Inhibit pathway activity, serving as a negative regulator.
- **Neuronal differentiation:** Participate in the regulation of gene expression in the nervous system.
- **Transcriptional regulation:** Acts as a transcriptional corepressor, influencing various gene expressions under specific physiological conditions.
  
Additional research may link SKOR1 to pathways related to synaptic plasticity and neuronal survival, especially in the context of development and response to cellular stress.

### Summary

The SKOR1 gene has crucial roles in BMP signaling regulation and transcriptional control, particularly in neuronal contexts. Understanding its interactions, particularly with aging or potential pharmacological effects, will require ongoing research to fully elucidate its biological significance.