### JTB Gene Overview

**Gene Symbol:** JTB  
**Gene Function:** The JTB gene encodes a protein that primarily facilitates protein kinase binding activity and is essential for normal mitotic cytokinesis. It is involved in the positive regulation of protein kinase activity and is localized in the cytoplasm, particularly at the midbody. Key functions of JTB include contributing to cell proliferation regulation and potentially being a part of the chromosomal passenger complex (CPC), which plays a critical role in proper chromosome alignment and segregation during mitosis. Notably, JTB enhances the activity of Aurora kinase B (AURKB), vital for mitosis, and inhibits apoptosis induced by transforming growth factor beta 1 (TGFB1). Overexpression of JTB has also been shown to lead to mitochondrial swelling and disrupt mitochondrial membrane potential.

### Additional Associations
1. **Associated Genes:**
   - **AURKB (Aurora kinase B):** JTB enhances the activity of AURKB.
   - **BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase):** Involved in the spindle assembly checkpoint alongside JTB.
   - **KIF23 (Kinesin Family Member 23):** Associated with cytokinesis and may interact with JTB.
   - **CDK1 (Cyclin-Dependent Kinase 1):** Important in the progression of the cell cycle and mitotic regulation.

2. **Age-Related Information:**
   - While specific details linking JTB directly to aging or age-related diseases are limited, its function in cell proliferation and apoptosis regulation suggests a potential role in age-related cancer development and cellular senescence.
   - Dysregulation of mitotic processes and apoptosis is commonly implicated in age-related diseases, indicating that alterations in JTB expression could potentially influence such conditions.

3. **Drug Interactions:**
   - There are no specific drugs or drug classes universally known to directly interact with JTB; however, because of its role in cell cycle regulation and potential involvement in cancer pathways, general cancer therapies targeting mitotic processes (such as Aurora kinase inhibitors) may have relevance.
   - Research surrounding targeted therapies for conditions involving JTB dysfunction may yield insights into more direct interactions.

4. **Pathways and Biological Processes:**
   - **Mitotic Cytokinesis:** Essential for successful cell division.
   - **Aurora B Signaling Pathway:** JTB's enhancement of AURKB links it to multiple aspects of mitotic regulation.
   - **Apoptosis Regulation:** Inhibition of apoptosis suggests involvement in processes leading to cell survival.
   - **Cell Cycle Regulation:** Plays a role in regulating checkpoints and transitions throughout the cell cycle.
   - **Centromere and Chromosomal Passenger Complex Activity:** Essential for chromosome management during cell division.

### Summary
The JTB gene encodes a protein crucial for proper mitotic processes and cell proliferation, with associations to various kinases and regulatory proteins. Its functions and interactions highlight its potential relevance in cancer biology and possibly age-related cellular changes, despite specific direct links to aging being less defined. Future research may illuminate more about JTB's roles in both health and disease, particularly in the context of therapeutic targeting.