The **ENO4** gene, also known as **enolase 4**, is a member of the enolase family, which includes enzymes that play key roles in glycolysis and other metabolic pathways. Here’s a detailed overview based on your request:

### 1. Associated Genes
While the summaries provided do not explicitly list genes associated with ENO4, it is generally part of pathways linked with glucose metabolism. ENO4 may have functional associations with other enolases (such as ENO1, ENO2, ENO3) that are involved in similar or compensatory metabolic processes. Other genes involved in sperm motility and glycolysis could also be considered, including **TPI1**, **LDHA**, **PGK1**, and genes involved in ciliary function such as **IFT20** and **IFT88**.

### 2. Aging and Age-Related Diseases
There is limited direct literature connecting ENO4 specifically to aging or age-related diseases. However, its primary roles in metabolic processes suggest possible implications in conditions like diabetes mellitus and various metabolic syndromes that are linked to aging. Altered metabolism is typically observed with age, and any dysfunction in glucose metabolism could lead to age-related muscle decline, fatigue, and impaired overall metabolic health.

### 3. Drug Interactions
Currently, there isn't a well-defined list of drugs specifically targeting ENO4 available in public databases. However, as it is involved in glycolytic processes, one might infer existing interactions with agents that influence metabolic enzymes, though these would generally be through broader metabolic pathways rather than targeting ENO4 specifically. Common drug classes that might influence glycolysis pathways could include insulin sensitizers and antidiabetic drugs, although specific interactions with ENO4 have not been established.

### 4. Pathways and Biological Processes
ENO4 is primarily involved in the following biological pathways:

- **Glycolysis:** Serving as a phosphopyruvate hydratase, ENO4 plays a critical role in the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway.
- **Spermatogenesis and Sperm Motility:** As suggested, ENO4 is implicated in sperm function, possibly affecting motility and overall fertility.
- **Cilium Organization:** Indicated to have a role in cilium organization which is crucial for cell signaling and motility in various cell types, including sperm.
- **Vacuole Fusion Regulation:** Suggests involvement in cellular processes related to membrane dynamics.

Overall, ENO4 is an enzyme integral to energy metabolism and cell motility, particularly in sperm cells, but more research is necessary to fully elucidate its roles and potential clinical significances.