### CORO7 Gene Summary

**Gene Symbol:** CORO7

**Function:** The CORO7 gene encodes a protein that is part of the coronin family, notable for its role in F-actin regulation rather than direct actin binding. It facilitates the transport of cargo from the Golgi apparatus to endosomes by modifying F-actin dynamics in the trans-Golgi network. The protein has two WD-40 repeats that are instrumental for its function and localization.

**Ubiquitination:** CORO7 undergoes K33-linked polyubiquitination via a specific E3 ligase complex (BCR/KLHL20), which is crucial for its interaction with other proteins, such as EPS15, and affects its localization and function at the trans-Golgi network.

**Morphological Role:** The gene is implicated in maintaining the structure of the Golgi apparatus, thereby playing a critical role in cellular transport and organization.

### 1. Associated Genes
While there might not be specific additional genes listed in the summaries, genes that are commonly studied in relation to CORO7 might include those involved in cytoskeleton organization, vesicular transport, and other members of the coronin family such as **CORO1A**, **CORO1B**, and **CORO8**. Additionally, genes like **EPS15** that interact with CORO7 are significant in the context of post-Golgi trafficking.

### 2. Aging and Age-Related Diseases
As of my last knowledge update, there were no specific studies directly linking CORO7 to aging or age-related pathologies in the literature. However, given its role in cellular transport and maintenance of Golgi morphology, any dysfunction in CORO7 could theoretically contribute to cellular aging processes or conditions associated with impaired trafficking and organelle function (e.g., neurodegenerative diseases). Further investigation is necessary to establish any concrete associations.

### 3. Drug and Drug Classes
Currently, there are no widely recognized drugs or drug classes specifically targeting CORO7 described in the literature. The interaction with the E3 ligase complex suggests potential pathways through which pharmacological agents affecting ubiquitination could indirectly influence CORO7 functionality, but no direct interactions have been documented.

### 4. Pathways and Biological Processes
CORO7 is involved in several important biological processes, including:
- **Anterograde transport**: Specifically aiding in the movement of materials from the Golgi apparatus to endosomes.
- **Actin polymerization**: Promoting the dynamics of the actin cytoskeleton, which is crucial for various cellular processes including motility, shape changes, and division.
- **Regulation of vesicle trafficking**: Integral in the mechanisms that maintain cellular transport and organelle integrity.

**Intracellular Localization:** It localizes primarily to the trans-Golgi network, emphasizing its role in trafficking and organization within the Golgi apparatus.

Further research will likely shed more light on the complete scope of CORO7's biological functions and its implications in health and diseases.