### FGF10-AS1 Gene Overview

**Gene Symbol**: FGF10-AS1  
**Location**: Chromosome 5  
**Type**: Long non-coding RNA (lncRNA)  
**Function**: The FGF10-AS1 gene is an antisense RNA that is believed to play a regulatory role in the expression of the nearby FGF10 gene, which is a member of the fibroblast growth factor family involved in various biological processes.

#### 1. Associated Genes
While the summaries from NCBI and UniProt primarily focus on FGF10, FGF10-AS1 is likely to have regulatory associations with other genes, particularly those involved in developmental processes and cellular signaling pathways. Some structurally or functionally related genes include:

- **FGF10**: The major target gene, playing a crucial role in tissue development and maintenance of various organs.
- **FGF2**: Another fibroblast growth factor involved in angiogenesis and wound healing.
- **ETV4** (ETS Variant Transcription Factor 4): This transcription factor may be involved in pathways regulated by FGF signaling.
- **KRT17** (Keratin 17): Involved in keratinocyte proliferation and differentiation, possibly influenced by FGF signaling.

#### 2. Aging and Age-related Diseases
The FGF10-AS1 gene is implicated in developmental processes and tissue repair, which may indirectly relate to aging and age-related diseases. Aberrations in fibroblast growth factor signaling pathways (which may be influenced by FGF10-AS1) are associated with:

- **Age-related macular degeneration**: FGF signaling is involved in the regulation of retinal vascularization.
- **Pulmonary diseases**: FGF10 is associated with pulmonary development and repair, suggesting a potential link with age-related lung conditions.
- **Cancers**: Alterations in FGFs and their regulatory networks have been implicated in carcinogenesis, and the expression profiles of lncRNAs such as FGF10-AS1 might change with age, contributing to tumorigenesis.

#### 3. Drug Interactions
At present, specific drugs or drug classes targeting the FGF10-AS1 gene directly have not been thoroughly documented. However, drugs affecting fibroblast growth factor signaling pathways could inadvertently influence FGF10-AS1:

- **FGF inhibitors**: They are being explored in clinical trials for conditions where FGF signaling is aberrant, such as specific cancers.
- **Chemotherapy agents**: Certain agents may indirectly affect lncRNA expression, including FGF10-AS1, in cancer therapy contexts, although the specifics are often unknown.

#### 4. Pathways and Biological Processes
FGF10-AS1 may be involved in several biological processes including:

- **Regulation of FGF10 expression**: As it is an antisense RNA, FGF10-AS1 might modulate the transcription of FGF10.
- **Wound healing**: FGF signaling is crucial in the processes of cell proliferation and migration during tissue repair.
- **Lung and limb development**: It is associated with embryonic development and organogenesis facilitated by FGF10.

**Biological pathways potentially influenced by FGF10 and its regulatory mechanisms include:**

- **MAPK signaling pathway**: FGF signaling commonly activates this pathway, affecting cell proliferation and survival.
- **Developmental Biology Pathways**: Involves limb and organ development processes where FGF10 plays a significant role.

### Summary
FGF10-AS1 is a long non-coding RNA associated with the regulation of the FGF10 gene, playing a significant role in developmental biology and potentially influencing age-related diseases. While direct interactions with specific drugs have not been established, its involvement with FGF signaling pathways suggests that it might be relevant to therapeutics targeting these pathways. Further research could elucidate more specific interactions, particularly in the context of aging and disease.