### ARRDC3 Gene Overview

**Gene Symbol**: ARRDC3

**Function**: The ARRDC3 gene encodes an arrestin family member, a group of proteins involved in regulating G protein-mediated signaling pathways. This gene is implicated in the modulation of breast cancer growth and progression through its interaction with phosphorylated integrin beta4, facilitating its internalization and subsequent degradation. The protein may also play roles in the endocytosis and degradation of adrenergic receptors, particularly the ADRB2 receptor, by potentially recruiting E3 ubiquitin ligase NEDD4.

### Additional Associated Genes

While the summaries primarily highlight interactions with ADRB2 and integrin beta4, ARRDC3 may also interact with other genes involved in the endocytic and ubiquitination pathways. Some genes associated with ARRDC3 include:

1. **ADRB2** (Beta-2 adrenergic receptor) - Directly interacts with ARRDC3 as a substrate for endocytosis.
2. **NEDD4** - E3 ubiquitin ligase that may be recruited by ARRDC3 for the ubiquitination of target proteins.
3. **ITGB4** (Integrin beta-4) - Another key regulatory substrate in cancer progression.

### Aging and Age-Related Diseases

Research explicitly linking ARRDC3 to aging or age-related diseases is limited. However, its involvement with G protein-coupled receptors (GPCRs), ligands of which often change in expression with age, suggests possible indirect associations. Cell signaling alterations in aging could impact cancer development, particularly since ARRDC3 is implicated in tumor growth regulation. Greater focus on GPCR signaling in senescent cells or age-related remodeling of tissue could provide insights into how ARRDC3 might affect longevity or age-related pathologies.

### Drug Interactions

Currently, specific drugs explicitly known to interact with the ARRDC3 protein have not been firmly established in published studies. However, given the gene's involvement in adrenergic signaling and its role in regulating ADRB2, drugs that target adrenergic receptors, such as:

1. **Beta-blockers** (e.g., Atenolol, Metoprolol) - These drugs alter the signaling pathways that involve ADRB2, potentially implicating ARRDC3 in their effects.
2. **Bronchodilators** (e.g., Albuterol) - Given their interaction with adrenergic receptors, these may indirectly highlight functional outcomes related to ARRDC3.

### Pathways and Biological Processes

ARRDC3 is involved in several crucial biological pathways and processes:

1. **G protein-coupled receptor endocytosis** - ARRDC3 plays a central role in the internalization and regulation of GPCRs, notably adrenergic receptors.
2. **Ubiquitin-dependent protein catabolism** - The activation of pathways involved in ubiquitination facilitates the proteasomal degradation of proteins, including ADRB2.
3. **Cell signaling pathways** - It is implicated in various signaling pathways related to cancer progression and cellular responses to external stimuli.
4. **Regulation of intracellular receptor trafficking** - ARRDC3 acts as an adapter protein that mediates the transport of receptors to different cellular compartments.

In summary, ARRDC3 is a multifaceted gene contributing to cancer biology, receptor regulation, and potentially intersects with the biology of aging and drug response, though more targeted research is necessary for deeper insights.