### ABHD17C Gene Summary

**Gene Symbol:** ABHD17C  
**Function:** ABHD17C (Abhydrolase Domain Containing 17C) is implicated in palmitoyl-(protein) hydrolase activity, which involves the hydrolysis of fatty acids from S-acylated cysteine residues in proteins. As a depalmitoylating enzyme, ABHD17C plays a crucial role in regulating protein localization and function, particularly in signaling pathways, synaptic transmission, and substrate specificity.

**Location:** The gene is predicted to be active in various cellular compartments, including:
- Endosome membrane
- Glutamatergic synapse
- Plasma membrane

**Substrates:** Known substrates for ABHD17C include NRAS (a member of the RAS family of proteins involved in cell signaling) and DLG4/PSD95 (a scaffolding protein in neurons critical for synaptic signaling).

### 1. Associated Genes

While specific direct interactions may not be fully detailed in the summaries provided, ABHD17C may be indirectly associated with genes involved in similar pathways, particularly those regulating synaptic function and lipid metabolism. Notable genes potentially related due to overlapping functions include:
- **NRAS:** As mentioned, ABHD17C has depalmitoylating activity towards NRAS.
- **DLG4/PSD95:** A key protein in postsynaptic density and synaptic signaling.

Other associated genes potentially include those encoding:
- Other members of the ABHD enzyme family (like ABHD17A and ABHD17B), which may have overlapping or compensatory functions. 
- Lipid-metabolizing enzymes, such as those involved in the regulation of palmitate metabolism.

### 2. Aging and Age-Related Diseases

Current research on ABHD17C and its relationship to aging or age-related diseases is limited. However, given its role in protein depalmitoylation, which is crucial for maintaining neuronal function and plasticity, alterations in its activity may play a role in neurodegenerative diseases associated with aging, such as:
- Alzheimer's disease
- Parkinson's disease

Increased aggregation of misfolded proteins related to lipid metabolism and alterations in synaptic function might link ABHD17C to age-related cognitive decline and synaptic degeneration.

### 3. Drug Interactions

While no specific drugs are highlighted as direct interactors with ABHD17C, compounds that modulate lipid metabolism or synaptic function may influence its activity. Potential classes of drugs that might interact include:
- **Antipsychotics:** These drugs can affect neurotransmission and synaptic plasticity, indirectly influencing the pathways ABHD17C is involved with.
- **Cannabinoid-related compounds:** Given that ABHD17C is involved in lipid hydrolysis, synthetic cannabinoids may indirectly affect its function.

### 4. Pathways and Biological Processes

ABHD17C is known to be involved in several biological processes, including but not limited to:
- **Protein depalmitoylation:** A critical process that regulates protein interactions and localization.
- **Metabolism of lipids:** Key in balancing lipid homeostasis in cells.
- **Synaptic transmission:** Especially in glutamatergic signaling, which is important for cognitive functions.
- **Cell signaling pathways:** Particularly those involving membrane-associated proteins, potentially modulating behavior in response to external stimuli.

ABHD17C likely plays a role in broader signaling and metabolic pathways, including those associated with synaptic plasticity, cellular stress responses, and neuronal differentiation. Further studies may delineate its exact roles in health and disease.