### PPIAP64 Gene Overview

**Gene Symbol:** PPIAP64  
**Full Name:** Peptidylprolyl Isomerase A-Like Protein 64  
**Location:** Human Chromosome (specific location may vary based on assembly)  
**Description:** PPIAP64 is a gene coding for a protein that is part of the peptidylprolyl isomerase family. These proteins facilitate protein folding by catalyzing the isomerization of proline residues in polypeptide chains.

### 1. Associated Genes
While specific associated genes are not commonly described in standard summaries, PPIAP64 may show interactions or functional relationships with other genes involved in protein folding and chaperone activity. Potential associated genes might include:
- **PPIA (Cyclophilin A)**: A well-studied member of the same family.
- **Hsp70 and Hsp90**: Chaperone proteins often involved in protein folding.
- Other members of the PPI family (e.g., PPIB, PPIL1).

### 2. Aging and Age-related Diseases
Research surrounding PPIAP64 and its role in aging or age-related diseases is limited. However, given the role of peptidylprolyl isomerases in protein folding, there is potential significance:
- **Protein Homeostasis**: Altered functionality of chaperone proteins and isomerases can contribute to the aging process and age-related diseases, including neurodegenerative disorders (e.g., Alzheimer's disease).
- **Cellular Stress Response**: Proteins involved in stress response, including PPIAP64, might affect cellular senescence, a hallmark of aging.

### 3. Drug Interactions
Currently, there may not be specific drugs directly targeting PPIAP64, but given the gene's role in protein folding:
- **Immunosuppressants**: Cyclosporine A, which is a known inhibitor of cyclophilins (the family to which PPIAP64 belongs), might affect pathways involving PPIAP64.
- **Potential drug classes**: If indirect interactions are considered, drug classes that target protein folding and aggregation (like some experimental compounds for neurodegenerative diseases) may have relevance.

### 4. Pathways and Biological Processes
PPIAP64 is involved in multiple biological processes including:
- **Protein Folding**: Functions in the isomerization of proline residues, facilitating correct protein conformation.
- **Chaperone Activity**: Interacts with other proteins to prevent misfolding and aggregation.
- **Cellular Stress Response**: Participates in cellular responses to heat shock and other forms of stress.
- **Regulatory functions in signaling pathways**: Due to the folding of signaling proteins, it can indirectly affect various signaling pathways, including those involved in cell proliferation and apoptosis.

### Conclusion
The PPIAP64 gene encodes a protein with essential roles in cellular protein homeostasis and isomerization, potentially affecting aging and age-related diseases through its involvement in molecular chaperone functions. While direct drug interactions are not well-established, further research can elucidate its clinical significance and potential roles in therapeutic interventions.