### DVL3 Gene Overview

**Gene Symbol**: DVL3  
**Function**: The DVL3 gene encodes a cytoplasmic protein that is part of the dishevelled gene family, which plays a critical role in Wnt signaling pathways. These pathways are vital for cell proliferation, cell fate determination, and developmental processes.

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### 1. Associated Genes

DVL3 interacts with multiple genes involved in Wnt signaling and related pathways. Below are some notable examples:

- **WNT Genes**: These are a family of genes (WNT1, WNT3A, WNT5A, etc.) that encodes signaling proteins involved in various developmental processes.
- **APC (Adenomatous polyposis coli)**: A tumor suppressor gene that interacts with DVL proteins in the context of Wnt signaling and regulation of β-catenin.
- **CTNNB1 (Beta-catenin)**: A central component of the canonical Wnt signaling pathway, its activity is regulated by DVL proteins.
- **GSK3B (Glycogen synthase kinase 3 beta)**: An enzyme that phosphorylates β-catenin; DVL proteins help regulate this phosphorylation during Wnt signaling.

### 2. Aging and Age-Related Diseases

DVL3 is implicated in several age-related conditions due to its role in cellular signaling pathways that govern cell proliferation and differentiation. Some key points include:

- **Cancer**: Dysregulation of DVL3 and Wnt signaling has been associated with various cancers, especially colorectal cancer, which tends to increase with age.
- **Neurological Disorders**: Alterations in Wnt signaling, including those mediated by DVL3, have been linked to neurodegenerative diseases, such as Alzheimer's disease, which manifests commonly in older populations.
- **Stem Cell Regulation**: DVL3 is involved in maintaining stem cell pluripotency and self-renewal, processes that decline with age and can impact tissue regeneration.

### 3. Drug Interactions

While specific drugs targeting DVL3 directly may not be extensively documented, certain classes of drugs have implications on Wnt signaling, which may, in effect, influence DVL3 activity:

- **Wnt Pathway Inhibitors**: These include small molecules that can influence the stability and activity of β-catenin, which may indirectly affect DVL3 function.
- **Antipsychotics**: Some studies have explored connections between antipsychotic medications and the modulation of Wnt signaling pathways, as dysregulation of DVL3 is observed in certain mental health conditions.
  
### 4. Pathways and Biological Processes

DVL3 is involved in various pathways and biological processes:

- **Wnt Signaling Pathway**: DVL3 is a key mediator in both the canonical and non-canonical Wnt signaling pathways. 
- **Cell Migration and Invasion**: DVL3 influences processes related to cellular movement, critical in both developmental biology and cancer metastasis.
- **Neurogenesis**: It plays a role in neural progenitor cell proliferation and differentiation during embryonic development.
- **Regulation of Gene Expression**: DVL3 interacts with transcription factors and co-factors that modulate gene expression in response to Wnt signaling.

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In summary, DVL3 is a multifaceted gene integral to the Wnt signaling pathway, with connections to various developmental processes, cancer biology, and potential implications in age-related diseases. Its interactions with numerous other genes further highlight its importance in cellular signaling and systemic health.