### NDC1 Gene Overview

**Symbol:** NDC1  
**Location:** Nucleus  
**Function:** The NDC1 gene encodes a protein that is essential for the assembly and function of the nuclear pore complex (NPC), which is critical for nucleocytoplasmic transport. The protein is involved in linking nuclear envelope membranes with nucleoporins, thereby anchoring NPCs in the nuclear membrane.

### 1. Associated Genes
While specific interactions may vary, several genes are often studied in conjunction with NDC1 due to their related functions in nuclear pore complex assembly and transport mechanisms. This includes:
- **NUP93:** A nucleoporin that is essential for the structural integrity and function of the NPC.
- **NUP98:** Involved in NPC assembly and transport functions.
- **NUP62:** Another nucleoporin that plays a role in transport processes through the NPC.
- **NUP205:** A component of the nuclear pore complex.

### 2. Aging and Age-Related Diseases
While direct associations between NDC1 and aging or specific age-related diseases are not fully elucidated, disruptions in the function of nuclear pore complexes have been linked to various cellular aging processes. These include:
- **Cellular senescence:** Impaired nuclear transport can contribute to cellular aging and senescence.
- **Neurodegenerative diseases:** Some studies suggest that mutations or dysfunction in nuclear pore complexes may be implicated in age-related neurodegenerative diseases (e.g., Alzheimer's and Huntington’s).
- **Cancer:** Alterations in nuclear transport pathways can result in genomic instability, a hallmark of cancer, which becomes more prevalent with age.

### 3. Drug Interactions
As of the knowledge cutoff in October 2023, specific drugs directly targeting NDC1 itself are not well-documented. However, it is known that:
- **Nuclear transport inhibitors:** Drugs that impact nuclear transport by targeting nucleoporins or the nuclear pore complex may indirectly affect NDC1 function.
- **Covalent modifiers:** Some chemotherapeutic agents or compounds that modify cellular signaling pathways could impact the expression or function of NDC1 due to its role in cellular transport and signaling.

### 4. Pathways and Biological Processes
The NDC1 gene is involved in several critical biological pathways, including:
- **Nuclear pore complex assembly:** Integral in the establishment and maintenance of the nuclear pore structure.
- **Nuclear transport:** Facilitates the selective transport of proteins and RNA across the nuclear envelope.
- **Cell cycle regulation:** Through its role in nuclear envelope dynamics, NDC1 may participate in processes related to cell division.
- **Cellular signaling:** By mediating nuclear transport, it can influence various signaling pathways that rely on nuclear translocation.

In summary, NDC1 is a pivotal gene in maintaining the cellular architecture and transport mechanisms essential for proper cell function, with broader implications in aging and disease when its normal function is disrupted.