### SNORA14B Gene Overview

- **Gene Symbol:** SNORA14B
- **Gene Type:** Small nucleolar RNA (snoRNA)
- **Length:** 60-150 nt
- **Function:** SNORA14B is classified as an H/ACA box snoRNA that serves as a guide for the isomerization of uridine to pseudouridine in ribosomal RNA (rRNA), specifically at position U966 of 18S rRNA.

### Associated Genes

In addition to its direct function, SNORA14B may be associated with the following genes:
- **SNORA14A:** A closely related gene that is located on chromosome 7 and is 91% identical to SNORA14B.
- Other **snoRNA genes** involved in rRNA modification may also have functional overlaps, including members of the H/ACA box class, such as **TRUB1** and **DKC1**, which are involved in pseudouridylation.

### Aging and Age-Related Diseases

The role of SNORA14B in ribosomal function and RNA modification may link it to processes related to aging and age-related diseases. Although specific literature on SNORA14B directly relating to aging is limited, snoRNAs in general have been implicated in:
- **Cellular senescence:** Changes in the expression of snoRNAs have been observed in aged tissues.
- **Cancer:** Dysregulation of snoRNAs can influence rRNA processing and ribosome biogenesis; hence, they may also be involved in tumorigenesis.
- **Neurodegeneration:** Altered snoRNA levels have been observed in neurodegenerative diseases, suggesting a potential link through altered protein synthesis.

### Drug Interactions

To date, there are no specific drugs or drug classes directly known to interact with SNORA14B. However, given its role in rRNA pseudouridylation and ribosome function, drugs targeting general cellular processes such as translation regulation could have indirect effects on the expression or activity of molecules influenced by snoRNAs.

### Pathways and Biological Processes

SNORA14B is involved in several biological processes:
- **rRNA processing:** As a snoRNA, it plays a crucial role in the chemical modification of rRNA, which is essential for ribosome assembly and function.
- **Pseudouridine synthesis:** It specifically guides the conversion of uridine into pseudouridine in rRNA—important for ribosomal stability and function.
- **Nucleotide metabolic processes:** Since it functions in the modification of nucleotides within rRNA, it contributes indirectly to broader nucleotide metabolism.
- **Cellular processes involving ribosome biogenesis:** Modifications guided by snoRNAs are essential for the proper assembly of ribosomes, influencing overall protein synthesis and cell growth.

In summary, SNORA14B is a significant player in rRNA modification, contributing to essential cellular functions linked to translation and potentially influencing aging and disease processes. Further research may elucidate more specific roles and interactions associated with this snoRNA.