### DHX15 Gene Overview

**Gene Symbol**: DHX15  
**Gene Description**: The DHX15 gene encodes a putative ATP-dependent RNA helicase that plays a significant role in pre-mRNA splicing and antiviral innate immunity. This protein is crucial for RNA processing, particularly in disassembling spliceosomes post-mRNA release, and participates in recognizing and binding viral double-stranded RNA (dsRNA). It orchestrates various signaling pathways essential for the body's immune response, especially in the context of viral infections.

### 1. Associated Genes
While the summaries provided highlight a few genes and protein factors with which DHX15 interacts (e.g., TFIP11, MAVS, and NLRP6), associated or interacting genes may also include:

- **MAVS** (Mitochondrial Antiviral Signaling Protein)
- **NLRP6** (NOD-like Receptor Family Pyrin Domain Containing 6)
- **IL18** (Interleukin 18)
- **U2, U5, U6 snRNP components** (small nuclear ribonucleoproteins)
- **TRAF3** (TNF Receptor Associated Factor 3), involved in signaling pathways related to inflammation and immune responses.

### 2. Aging and Age-Related Diseases
Research into the role of DHX15 in aging is still ongoing. However, pertinent details may include:

- **Inflammation and Immunity**: Aging is associated with changes in immune response known as immunosenescence. Given that DHX15 participates in antiviral immunity, it may be implicated in age-related vulnerability to viral infections.
- **Cancer**: As an RNA helicase, DHX15 may be involved in RNA metabolism related to oncogenesis. Abnormalities in splicing factors are often observed in cancer, suggesting a potential link to age-related malignancies.
- **Neurodegenerative Diseases**: Some studies have directed attention to the role of RNA processing and splicing defects in neurodegenerative diseases that are prevalent in older adults.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes directly identified that target DHX15. However, due to its involvement in antiviral immunity, modulation of immune signaling pathways via interferon-based therapies or other antiviral agents could indirectly influence the action of DHX15. Future research may define potential therapeutic compounds or classes that interact more specifically with this gene in disease contexts.

### 4. Pathways and Biological Processes
DHX15 is involved in several critical biological pathways:

- **mRNA Processing**: It is crucial for spliceosome disassembly and subsequent mRNA maturation.
- **Antiviral Innate Immunity**: Through its interaction with dsRNA, DHX15 activates MAVS signaling pathways that lead to the production of interferons (e.g., IFN-beta and IFN-lambda).
- **NLRP6 inflammasome activation**: DHX15 aids in recognizing viral dsRNA in intestinal epithelial cells, stimulating the activation of the NLRP6 inflammasome and promoting the maturation of IL-18, which is key in immune and inflammatory responses.
- **Antibacterial Innate Immunity**: DHX15 may play a role in the Wnt signaling pathway, contributing to antimicrobial peptide expression in Paneth cells, thus supporting intestinal defense mechanisms.

### Conclusion
Overall, the DHX15 gene is integral to the complex interplay of RNA biology and immune responses. Its role in both pre-mRNA processing and antiviral immunity highlights its potential importance in various diseases, particularly as they relate to aging and infection. Further research is warranted to clarify the gene's interactions and contributions to health and disease, especially in the context of age-related conditions.