**SNORD115-37 Gene Overview**

**Gene Symbol**: SNORD115-37

The SNORD115-37 gene is a small nucleolar RNA (snoRNA) gene that belongs to the C/D box class of snoRNAs. This class is known to be involved in the biogenesis of ribosomal RNA (rRNA) and in the post-transcriptional modification of rRNA and small nuclear RNAs (snRNAs). 

### 1. Associated Genes
While specific associations with other genes may not be extensively characterized, snoRNAs often function in conjunction with the ribosome assembly and might indirectly affect the expression of ribosomal protein genes. Additionally, there may be interrelated functions with other snoRNAs—particularly those within the SNORD115 cluster, which may include other members like SNORD115-40 and SNORD115-22. However, there may be genes that indirectly show associations via rRNA modification-related pathways, such as those involved in ribosome biogenesis and protein synthesis.

### 2. Aging and Age-Related Diseases
Current literature on SNORD115-37 points toward a broader interest in the snoRNA class and its implications in aging and age-related diseases. Some studies have found that changes in snoRNA expression profiles can be linked to neurodegenerative diseases and certain types of cancers, which are associated with aging. Specifically:

- **Neurodegenerative diseases**: Altered expression levels of snoRNAs have been observed in conditions like Alzheimer's and Parkinson's disease.
- **Cancer**: Some snoRNAs have been implicated in the regulation of tumor suppressor genes and cell proliferation, which could be significant in the context of aging and oncogenic processes.

However, as of now, direct associations between SNORD115-37 and specific aging or age-related disease mechanisms require further empirical investigation.

### 3. Drug Interactions
Currently, there are no well-defined drug interactions known for SNORD115-37 specifically. However, as with many snoRNAs, pharmacological agents targeting RNA metabolism, such as those affecting ribosome biogenesis and function, could indirectly impact the expression or activity of this snoRNA. 

- **Potentially relevant drug classes**: Antineoplastics (due to their influence on RNA processing), antibiotics targeting ribosomal RNA, and compounds that influence nucleic acid metabolism may exert effects, albeit indirectly.

### 4. Pathways and Biological Processes
SNORD115-37 is implicated in several biological processes, particularly due to its role as a snoRNA:

- **rRNA modification**: It plays a critical role in the methylation of ribosomal RNA, which is key for the proper functioning of ribosomes.
- **Ribosome biogenesis**: Involvement in the assembly of ribosomes, thus influencing protein synthesis.
- **Gene regulation**: Small nucleolar RNAs can also engage in processes affecting the expression of other RNAs, potentially influencing cytoplasmic and nuclear RNA stability.

In summary, while SNORD115-37 is primarily characterized by its role as a snoRNA in rRNA modification essential for ribosome function, a clear understanding of its associations with aging, disease, and drug interactions requires further study to crystallize its biological significance.