### RNF113B Gene Overview

**Gene Symbol**: RNF113B  
**Function**: The RNF113B gene encodes a protein that is predicted to enable metal ion binding activity and is thought to play a role in the splicing of small nucleolar RNAs (snoRNAs). Additionally, it is predicted to be a component of the U2-type spliceosomal complex, which is essential for mRNA processing.

### 1. Associated Genes
The RNF113B gene has various associations with other genes, particularly those involved in RNA processing and splicing mechanisms. Some potential gene associations include:
- **SNRPB** (Small nuclear ribonucleoprotein polypeptide B): A component of the spliceosome involved in mRNA splicing.
- **U2AF1** (U2 auxiliary factor 1): Plays a role in splicing regulation and recognition of the polyadenylation signal.
- **SBDS** (Shwachman-Bodian-Diamond syndrome): Involved in ribosome biogenesis and genetic disorders related to the splicing machinery.
  
Please note that while direct associations may be speculative, these genes represent functions within the same biological processes.

### 2. Aging or Age-related Diseases
As of the latest available data, specific studies directly correlating RNF113B to aging or age-related diseases may be limited. However, since RNF113B is involved in RNA splicing, it can be inferred that its dysfunction could potentially contribute to age-associated cellular and molecular changes. Defects in RNA processing and splicing have been implicated in several age-related diseases, including neurodegenerative disorders like Alzheimer's and some forms of cancer, though direct evidence linking RNF113B to specific age-related conditions has yet to be established.

### 3. Drug Interaction
Currently, there isn't well-documented evidence of specific drugs or drug classes that directly interact with the RNF113B gene or its protein product. However, as RNF113B is implicated in splicing pathways, drugs that target splicing mechanisms or RNA synthesis, such as certain antineoplastic agents or investigational splicing-modulating compounds, may indirectly affect its function.

### 4. Pathways and Biological Processes
RNF113B is involved in several important biological pathways, particularly those associated with mRNA processing and RNA metabolism. This includes:
- **mRNA Splicing**: Through its predicted role in the U2 spliceosomal complex, it plays a part in the removal of introns from precursor mRNA.
- **SnoRNA Processing**: Prediction of its involvement in snoRNA splicing adds to its relevance in ribosomal RNA maturation.
- **Metal Ion Binding**: The potential metal ion binding activity suggests a role in enzymatic processes that may involve metal co-factors.

In summary, RNF113B is a gene implicated in RNA processing, particularly in the context of splicing processes, with potential implications in aging and cellular function. Further studies are warranted to deepen the understanding of its role in disease and therapeutic contexts.