### DEPDC1 Gene Overview

**Gene Symbol:** DEPDC1  
**Location:** Nucleus  
**Function:** Predicted to enable GTPase activator activity and is involved in the negative regulation of transcription, DNA-templated.  
**Role:** May function as a transcriptional corepressor. The DEPDC1A-ZNF224 complex is implicated in bladder carcinogenesis.

### 1. Associated Genes
While the provided summaries mainly focus on DEPDC1 and its interaction with the A20 gene, other potential associations include:

- **ZNF224:** As mentioned, DEPDC1 forms a complex with ZNF224, playing a role in transcription repression.
- **NF-KB pathway-related genes:** Given the function of DEPDC1 in regulating NF-KB and the related processes, numerous genes within the NF-KB signaling pathway may be indirectly associated.

### 2. Aging and Age-Related Diseases
Though specific publications link DEPDC1 directly to aging or age-related diseases, its role in transcriptional regulation and cancer suggests it may have implications in:

- **Cancer development:** The repression of apoptosis through the DEPDC1A-ZNF224 complex may influence cellular aging and tumorigenesis.
- **Cellular Senescence:** Altered gene expression involving DEPDC1 could influence pathways related to cellular senescence, though more specific studies are necessary to confirm these associations.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly interact with DEPDC1 have not been extensively documented. However, the following considerations apply:

- **Anticancer drugs:** Given the role of DEPDC1 in bladder cancer, therapies targeting the NF-KB pathway or transcriptional regulators could be relevant.
- **Preventative agents:** Drugs aimed at apoptosis regulation may influence DEPDC1 downstream effects indirectly.

### 4. Pathways and Biological Processes
DEPDC1 is involved in several recognized pathways and biological processes, including:

- **Transcriptional regulation:** Its activity in repressing the transcription of vital genes like A20 and its interactions within repressor complexes.
- **NF-KB signaling pathway:** Through its influence on the activity and localization of NF-KB proteins.
- **Apoptosis regulation:** By modulating pathways that govern cell survival, especially in cancer scenarios.
  
### Summary
DEPDC1 plays a crucial role in transcriptional regulation and cancer biology, particularly related to bladder carcinoma. Its gene interactions, potential associations with aging, and role in critical biological processes highlight its importance in the study of cancer and gene regulation. Nonetheless, more research is needed to further elucidate its exact mechanisms and implications in various diseases.