### VASH1-AS1 Gene Overview

**Gene Symbol:** VASH1-AS1  
**Location:** VASH1-AS1 is an antisense RNA transcript corresponding to the VASH1 gene. The full name for the gene is VASH1 antisense RNA 1. 

**Function:** As an antisense RNA, VASH1-AS1 plays a regulatory role in the expression of its sense partner gene, VASH1 (Vasohibin 1), which is involved in angiogenesis and the regulation of vascular endothelial growth factor (VEGF). 

#### 1. Associated Genes
VASH1-AS1 is primarily associated with:

- **VASH1:** The primary sense gene its expression corresponds to, involved in anti-angiogenic processes.
- **Various genes involved in angiogenesis:** Though specific genes were not listed in your summary, it's common for angiogenesis-related genes to be connected, including FLT1 (VEGFR1), KDR (VEGFR2), and others.

#### 2. Aging and Age-Related Diseases
While specific studies may be limited, the regulation of angiogenesis is crucial in aging and age-related diseases. Abnormal angiogenesis is associated with conditions like:

- **Age-related macular degeneration (AMD)**
- **Cardiovascular diseases**
- **Cancer:** The role of VASH1 in regulating blood vessel formation may be relevant in tumor growth and metastasis.

Research shows that dysregulation of angiogenic factors often correlates with aging processes, suggesting potential implications for VASH1-AS1 in these contexts.

#### 3. Drug/Drug Classes Interaction
Currently, there is limited direct information regarding specific drugs or drug classes that interact explicitly with VASH1-AS1. However, given the role of VASH1 in angiogenesis, drugs targeting angiogenesis (anti-VEGF therapies, for example) may have indirect relationships via the regulation of VASH1, and by extension, VASH1-AS1. Specific drug examples might include:

- **Bevacizumab (Avastin)**: An anti-VEGF monoclonal antibody used in cancer therapy.
- **Sorafenib**: A multikinase inhibitor that targets VEGFR along with other pathways in cancer treatment.

#### 4. Pathways and Biological Processes 
VASH1-AS1 is implicated in several key biological processes and pathways, possibly including:

- **Regulation of Angiogenesis:** By influencing the expression of its sense gene VASH1, involved in modulating vascular endothelial growth factor signaling.
- **Response to Hypoxia:** VASH1 has roles in how cells respond to low oxygen conditions, which are prevalent in tumor biology and ischemia.
- **Tumor Metastasis and Growth Control:** Through its interactions with angiogenic factors, it may play roles in tumor progression.

In summary, VASH1-AS1 is an antisense RNA with regulatory functions related to angiogenesis through its association with the VASH1 gene, with potential implications in aging and related diseases. Its connection to drug interactions is primarily inferred through angiogenic pathways, and ongoing research may shed light on its precise roles in health and disease.