**HIF1A-AS3 Gene Overview:**

The HIF1A-AS3 gene, also known as hypoxia-inducible factor 1 alpha antisense RNA 3, is an antisense long non-coding RNA (lncRNA) that plays a regulatory role in gene expression and contributes to various biological processes. This gene is primarily located in the vicinity of the HIF1A (hypoxia-inducible factor 1 alpha) gene, which is critical for cellular response to hypoxia.

### 1. Associated Genes:
While the summaries from NCBI and UniProt might not list all associated genes, based on functional genomics and expression studies, the HIF1A-AS3 gene is primarily associated with the HIF1A gene due to its antisense nature. Additional associations may include:

- **HIF1B** (Hypoxia-inducible factor 1 beta): As a heterodimeric partner to HIF1A.
- **VEGFA** (Vascular endothelial growth factor A): Often upregulated in response to HIF activation.
- **PDK1** (Pyruvate dehydrogenase kinase 1): Another gene regulated by HIF factors.
- **GLUT1** (Glucose transporter type 1): Regulated by HIF1 signaling pathways.

### 2. Aging and Age-related Diseases:
Details about HIF1A-AS3's role in aging specifically are limited, but its association with the HIF1A gene suggests potential involvement in processes related to cellular stress responses and metabolism, which can influence aging. 

- HIF signaling has been associated with the regulation of glycolysis, inflammation, and angiogenesis, which are all critical processes in age-related diseases like **cardiovascular diseases**, **cancers**, and **neurodegenerative disorders**.
- Dysregulation of hypoxia response or variations in HIF1A-AS3 may have implications in senescence, cell survival during aging, and tissue regeneration.

### 3. Drug Interactions:
As of the latest research:

- There are no specific drugs or well-characterized drug classes explicitly targeting HIF1A-AS3. However, drugs that modulate hypoxia signaling or HIF activity may indirectly affect the expression/function of this lncRNA. 
- **Histone deacetylase inhibitors (HDACi)** and **antioxidants** have been shown to impact histone modifications that can influence lncRNA expression and thus could theoretically interact with HIF1A-AS3 indirectly.

### 4. Pathways and Biological Processes:
HIF1A-AS3 is involved in several biological pathways and processes, including:

- **Hypoxia-inducible factor signaling pathway**: It regulates responses to low oxygen levels in the environment, influencing cellular adaptation to hypoxia.
- **Regulation of angiogenesis**: By interacting with the HIF pathway, it is implicated in blood vessel formation, which is crucial during tissue repair and development.
- **Cellular response to stress**: HIF1A-AS3 plays a role in how cells react to environmental stresses, impacting apoptosis and survival mechanisms.
- **Metabolic processes**: It may influence metabolic reprogramming during hypoxic conditions, affecting glycolytic pathways.

In summary, the HIF1A-AS3 gene is a critical player in hypoxia response regulation through its relationship with the HIF1A gene and is likely involved in biological processes relevant to aging and diseases associated with metabolic and oxygen availability contexts. Further research will continue to clarify its exact roles and interactions in diverse biological systems.