### OR8B4 Gene Overview

**Gene Symbol**: OR8B4  
**Location**: Located on chromosome 11 of the human genome.  
**Function**: The OR8B4 gene encodes an olfactory receptor that plays a crucial role in the detection of odorant molecules and initiation of the neuronal response to these stimuli, thereby impacting the sense of smell. The gene is a member of the G-protein-coupled receptor (GPCR) superfamily and is characterized by a 7-transmembrane domain structure, similar to other receptors for neurotransmitters and hormones.

### 1. Associated Genes
While no specific gene interactions have been explicitly provided for OR8B4, olfactory receptor genes typically coexist in close genomic proximity with other olfactory receptor genes, contributing to the large and diverse olfactory receptor gene family. Other olfactory receptor genes may include OR genes such as OR8B2, OR8B5, and others, which may share functional relationships and regulatory mechanisms. Specific associations within this family can often be explored using bioinformatics databases but are generally not referenced in standard summaries.

### 2. Aging or Age-Related Disease Associations
While specific studies directly linking OR8B4 to aging or age-related diseases are limited, it is known that olfactory reception tends to decline with age. A diminished sense of smell may be linked to neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Additionally, research suggests that changes in olfactory function can be indicative of aging-related neurodegeneration. However, the exact role of OR8B4 in aging or associated pathologies requires further investigation, and current literature may not definitively explain how variations in OR8B4 impact aging processes.

### 3. Drug Interactions
Currently, there is limited information available regarding specific drugs or drug classes that directly interact with the OR8B4 gene or its encoded receptor protein. As olfactory receptors, including OR8B4, generally mediate sensory functions rather than metabolism or pharmacokinetics, they are less commonly targeted by conventional therapeutic agents. Future research may reveal relationships between environmental agents (such as certain volatile compounds in drugs) and olfactory receptor activity.

### 4. Pathways and Biological Processes
OR8B4 is primarily involved in the following biological processes:
- **Olfactory Signaling Pathway**: Mediates the cellular processes related to smell and detection of odorants.
- **G Protein-Coupled Receptor Signaling Pathway**: Plays a role in signal transduction associated with various stimuli, including olfactory information.
- **Sensory Perception of Smell**: Contributes to the overall sensory perception of odorants.

Research into olfactory receptor pathways, including OR8B4, continues to explore their complex interactions with various signaling molecules and their contributions to perceivable smells, sensory integration, and memory associations related to olfaction.

### Summary
The OR8B4 gene is an intricate component of the olfactory system, characterized by potential functional variability among individuals due to its pseudogene status. Its relevance to aging-related olfactory decline and drug interactions remains to be systematically elucidated, warranting ongoing research into its broader biological significance.