The IL11RA gene, located on chromosome 9q33.3, encodes the interleukin-11 receptor alpha, which is part of a receptor complex critical for transducing signals from interleukin-11 (IL-11). This receptor plays an important role in various physiological and pathological processes, particularly in mesenchymal tissues.

### 1. Associated Genes
IL11RA is primarily known to function in coordination with the following genes:
- **IL6ST (gp130)**: This gene encodes the shared signal transducer for several cytokine receptors, including those for IL-6, IL-11, LIF, and others, resulting in shared signaling pathways.
- **CNTF (Ciliary Neurotrophic Factor)**: Another cytokine that shares receptor components.
- **OSM (Oncostatin M)** and **CT1 (Cardiotrophin 1)**: Part of the same family and utilize IL6ST for signaling.

Additionally, the gene may interact with other cytokine-related genes and signaling molecules affecting inflammation and development.

### 2. Aging and Age-Related Diseases
Research has indicated that IL-11 and its receptor, IL11RA, are implicated in age-related pathologies, particularly those affecting the skeletal system and fibrosis. Increased IL-11 signaling has been associated with:
- Osteoporosis: Elevated levels of IL-11 contribute to bone resorption and reduced bone formation.
- Fibrotic diseases: IL-11 promotes fibroblast activation, leading to tissue fibrosis, which is often associated with aging and age-related diseases like cardiac fibrosis and pulmonary fibrosis.
- Cancer: Dysregulated IL-11 signaling may contribute to tumor microenvironment modulation and metastatic processes, especially in age-related cancers.

### 3. Known Drug Interactions
While specific drugs targeting the IL11RA receptor are not widely reported, the following classes of agents may show interactions or modulation effects through IL-11 signaling pathways:
- **Monoclonal antibodies**: Some monoclonal antibodies, particularly those targeting cytokines or their receptors in fibrotic diseases and rheumatological conditions, may indirectly affect IL-11-mediated processes.
- **Anti-inflammatory agents**: Non-steroidal anti-inflammatory drugs (NSAIDs) may mitigate chronic inflammation in which IL-11 is involved.

### 4. Pathways and Biological Processes
IL11RA is involved in several crucial pathways and biological processes, including:
- **Cytokine signaling pathway**: Specifically, the signaling cascades activated by IL-11, requiring the cooperation of IL11RA and IL6ST.
- **Regulation of bone and tooth development**: IL11RA is essential for the normal development of craniofacial bones and teeth, as mutations can lead to dental anomalies.
- **Cell proliferation and differentiation**: IL-11 signaling influences mesenchymal stem cell fate, promoting differentiation into osteoblasts and modulatory effects on fibroblasts.
- **Inflammatory response**: Modulates the body's response to injury and inflammation through the activation of various signaling cascades involving STAT proteins.

Additionally, ongoing studies are aim to clarify the full functional role of IL11RA in health and disease, especially concerning its involvement in inflammatory diseases and its broader implications for skeletal health and beyond.