### PIK3IP1-DT Gene Overview

**Gene Symbol**: PIK3IP1-DT  
**Full Name**: PIK3IP1 Divergent Transcript  
**Gene Type**: Long non-coding RNA (lncRNA)  

#### 1. Associated Genes
PIK3IP1-DT has been associated with several other genes, particularly those involved in signaling pathways and cellular processes. Notably:
- **PIK3IP1**: As a divergent transcript, it shares regulatory elements with its protein-coding counterpart, which is involved in the regulation of the PI3K signaling pathway.
- Genes involved in the phosphatidylinositol 3-kinase (PI3K) pathway, such as **AKT1**, **PTEN**, and **MTOR**, may also be impacted in some way due to the regulatory role of PIK3IP1-DT in the pathway's activities, although specific direct associations may need further exploration.

#### 2. Aging and Age-related Diseases
There are a few indirect associations between PIK3IP1-DT and aging or age-related diseases:
- **Regulation of PI3K Pathway**: The PI3K pathway is crucial in many biological processes, including metabolism, growth, and resistance to apoptosis. Dysregulation of this pathway is often noted in cancer and age-related diseases such as neurodegenerative disorders.
- **Cognitive Aging**: Some studies suggest a potential role for long non-coding RNAs, including PIK3IP1-DT, in cognitive functions and possibly in age-related cognitive decline or diseases.
  
However, specific studies connecting PIK3IP1-DT directly to aging mechanisms or particular age-associated conditions are limited and may require further investigation.

#### 3. Drug Interactions
As of my last update, there are no specific drugs or drug classes directly reported to interact with the PIK3IP1-DT gene. However, any targeted therapies that modulate the PI3K-AKT pathway (like **PI3K inhibitors** or **AKT inhibitors**) may indirectly affect the expression or regulation of PIK3IP1-DT, as it is implicated in this pathway indirectly through its association with PIK3IP1.

#### 4. Pathways and Biological Processes
PIK3IP1-DT is involved in several key biological processes, primarily due to its relationship with the PIK3IP1 gene and the PI3K/AKT signaling pathway:
- **PI3K signaling pathway**: PIK3IP1-DT modulates the negative feedback regulatory loop in the PI3K pathway, suggesting its importance in cellular growth, survival, and metabolism.
- **Regulation of apoptosis and cell survival**: The expression of PIK3IP1-DT may play a role in regulating apoptotic processes in response to cellular stress.
- **Cellular differentiation and proliferation**: Given its involvement in the PI3K pathway, it may contribute to various cellular responses, including differentiation and proliferation.

Overall, the PIK3IP1-DT gene stands out as an interesting long non-coding RNA that is associated with significant signaling pathways and may have implications in age-related processes, although more research is necessary to establish clearer connections and mechanisms.