### Overview of PPIAP25 Gene

**Gene Symbol:** PPIAP25  
**Function:** PPIAP25, also known as Peptidylprolyl isomerase A, is a member of the peptidylprolyl isomerase (PPIase) family which catalyzes the cis-trans isomerization of proline residues in oligopeptides. These enzymes play a crucial role in protein folding, maturation, and regulation of various cellular processes.

### 1. Associated Genes
While specific associations were not detailed in the summaries, PPIAP25 could potentially be associated with other genes involved in protein folding, transduction pathways, or cellular stress responses. Some potential gene interactions may include:

- **PPIA (Peptidylprolyl isomerase A)**: Other members of the PPIase family.
- **HSP90 (Heat shock protein 90)**: Involved in protein folding and stabilization.
- **HSP70 (Heat shock protein 70)**: Known for assisting protein folding and protection from stress.
- **CALR (Calreticulin)**: A multifunctional protein involved in folding and quality control of proteins.

Specific interaction studies using co-immunoprecipitation, yeast two-hybrid systems, or other molecular biology techniques may yield more definitive associations.

### 2. Aging and Age-Related Diseases
Currently, there is limited direct literature linking PPIAP25 with aging or age-related diseases. However, as a member of the peptidyl prolyl isomerase family, indirectly:

- **Protein Misfolding Diseases**: PPIases like PPIAP25 may play a role in the management of proteostasis, where failure to maintain protein homeostasis leads to diseases such as Alzheimer’s, Parkinson’s, and other neurodegenerative diseases, which are often associated with aging.
- **Cellular Stress**: Proteins that assist in refolding misfolded proteins or targeting them for degradation may be affected by the aging process, suggesting that PPIAP25 could be indirectly linked to age-related pathologies.

Further studies focusing on PPIAP25's expression in aging models or patient cohorts with age-related diseases are needed to elucidate specific roles.

### 3. Drug Interactions
As of the last update, no specific drugs targeting PPIAP25 are widely recognized. However, due to its role in protein folding and interactions, it could theoretically interact with drugs that manipulate protein pathways or target chaperone functions, including:

- **Immunosuppressants**: Some PPIases serve as targets for immunosuppressive drugs (like cyclosporine).
- **Cancer Drugs**: Given that PPIases can be implicated in cancer cell proliferation, compounds targeting protein folding might intersect with PPIAP25 functions.

### 4. Pathways and Biological Processes
PPIAP25 is involved in several crucial biological processes and pathways, including but not limited to:

- **Protein Folding**: Essential for proper protein maturation and functionality.
- **Cell Cycle Regulation**: The efficient folding of cyclins and CDKs, which regulate the cell cycle, may be influenced by PPIases.
- **Signal Transduction**: Involved in various signaling pathways due to the necessity of protein conformation for receptor activation and downstream signaling.
- **Stress Response**: Involvement in cellular responses to stressors that lead to misfolded proteins.

### Conclusion
PPIAP25 is an important gene encoding a peptidylprolyl isomerase that contributes to various cellular functions. Its connection to aging and diseases, as well as potential pharmaceutical targets, requires further research to clarify its role and therapeutic potential.