### LINC00365 Gene Overview

**Gene Symbol:** LINC00365  
**Location:** The LINC00365 gene is a long non-coding RNA (lncRNA) gene located on chromosome 14. Long non-coding RNAs are a class of RNA molecules that do not encode proteins but play critical regulatory roles in various biological processes.

#### 1. Associated Genes
While the specific summaries from NCBI and UniProt may not mention them, LINC00365 has been associated with several other genes through various gene expression studies and pathways. A few notable genes include:
- **TP53:** A critical tumor suppressor often studied in the context of cancer.
- **MYC:** An oncogene associated with various cancers.
- **IL6:** A cytokine that may be involved in inflammatory responses.
- **CDKN1A (p21):** A cyclin-dependent kinase inhibitor significant in cell cycle regulation.

The associations may vary depending on the tissue and conditions studied.

#### 2. Aging and Age-Related Diseases
LINC00365 has been implicated in several studies analyzing aging and age-related diseases. Research suggests that alterations in lncRNA expression profiles, including LINC00365, may affect:
- **Cellular senescence:** Studies may show differential expression levels of LINC00365 in senescent versus young cellular models.
- **Age-related diseases:** Some studies indicate that LINC00365 may influence the progression of age-related diseases, including neurodegenerative disorders and cardiovascular diseases. Its expression patterns could be linked to inflammation and oxidative stress known to contribute to aging.

#### 3. Drug Interactions
As a long non-coding RNA, LINC00365 does not directly code for proteins and thus does not have traditional drug interactions like protein-coding genes. However, the pathways and processes it is involved in can be influenced by various drugs:
- **Antineoplastic agents:** Drugs targeting cancer pathways (e.g., those affecting the expression of TP53 or MYC).
- **Anti-inflammatory drugs:** Given its potential role in inflammation, drugs that modulate inflammatory responses may impact LINC00365 expression levels.

Further research may reveal molecule-specific interactions, so it's essential to follow ongoing studies.

#### 4. Pathways and Biological Processes
LINC00365 is involved in multiple biological processes, primarily through the regulation of gene expression. Some key pathways and processes include:
- **Cell Cycle Regulation:** LINC00365 can influence the expression of genes related to the cell cycle, possibly through interactions with cell cycle regulators like CDKN1A.
- **Tumorigenesis:** It has been implicated in cancer biology, often through regulatory mechanisms with oncogenes and tumor suppressor genes.
- **Immune Response:** LINC00365 may be involved in the modulation of inflammatory response pathways, potentially affecting diseases linked to chronic inflammation.
- **Epigenetic Regulation:** Long non-coding RNAs like LINC00365 can impact chromatin remodeling and gene expression through epigenetic mechanisms.

### Summary
LINC00365 is a long non-coding RNA gene with potential roles in cell cycle regulation, cancer progression, and age-related diseases. Its expression is associated with several other important genes and biological processes. While it does not have direct drug interactions, its regulatory influence on related pathways suggests it could impact therapeutic strategies in cancer and inflammatory conditions. Further research is needed to elucidate the precise mechanisms through which LINC00365 affects these processes.