### EPS8L3 Gene Overview

**Gene Symbol:** EPS8L3  
**NCBI Gene ID:** 84701  
**UniProt ID:** Q8TDA3

**General Function:**
The EPS8L3 gene encodes a protein that is closely related to epidermal growth factor receptor pathway substrate 8 (EPS8), which is involved in signaling pathways related to cell growth and development, particularly those activated by epidermal growth factor receptors. The specific function of the EPS8L3 protein remains to be fully elucidated, and it may play a role in similar pathways or in cellular responses to growth factors.

### 1. Associated Genes
While the summaries provided mention several interacting partners and gene products, EPS8L3 is also associated with the following genes:
- **EPS8**: Related in function to EPS8L3.
- **EPS8L2**: Part of the interaction complex of EPS8L3.
- **SOS1**: A guanine nucleotide exchange factor involved in RAS signaling.
- **ABI1**: An adaptor protein that can link signaling pathways to the cytoskeleton.
  
Other possible associates through functional interactions:
- **FASLG**: FAS ligand, involved in apoptosis, with which EPS8L3 has been reported to interact.

### 2. Aging or Age-Related Diseases
Research specifically linking EPS8L3 to aging processes or age-related diseases is limited. However, given its relation to signaling pathways typically involved in cell growth and differentiation, disruptions in its function may theoretically contribute to processes of cellular senescence and age-associated degeneration or cancer. There is a growing body of literature on how signaling pathways, particularly those involving growth factors, are altered with age and might influence aging-related pathologies, but specific studies on EPS8L3 may need focused investigation.

### 3. Drug Interactions
Currently, no specific drugs or drug classes are widely reported as directly interacting with EPS8L3. Given the involvement of EPS8-related pathways in cancer and cell signaling, potential future therapeutic agents targeting these pathways could indirectly affect EPS8L3 function. Research into small molecule inhibitors or biologicals targeting the EGF signaling cascade may be of relevance, but direct interactions remain to be identified.

### 4. Pathways and Biological Processes
EPS8L3 is involved in various biological pathways and processes, including:

- **Epidermal Growth Factor Receptor Signaling Pathway**: As a related substrate, EPS8L3 may be indirectly involved in the downstream effects of EGF signaling.
- **Cell Proliferation and Growth**: Due to its homology to EPS8, involvement in cellular growth and differentiation signals can be inferred.
- **Cytoskeletal Organization**: Interactions with proteins that are part of the cytoskeleton imply a role in organizing the intracellular scaffold and cellular mobility.

### Conclusion
While EPS8L3 is associated with significant signaling pathways and interacts with various key proteins, further experimental studies are required to elucidate its precise role and potential clinical implications in the context of diseases, aging, or targeted therapies. The exploration of its impact on cellular functions may reveal important insights into its biological significance.