### CARD14 Gene Overview

**Gene Symbol**: CARD14 (Caspase Recruitment Domain Family, Member 14)

**Function**: 
CARD14 encodes a protein that belongs to the caspase recruitment domain (CARD) family and is a member of the membrane-associated guanylate kinase (MAGUK) family. As a scaffold protein, it facilitates interactions with various signaling molecules, playing a crucial role in cellular processes such as adhesion, signal transduction, and maintaining cell polarity. Notably, CARD14 can activate inflammatory pathways including the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and the p38/Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinase signaling pathways. 

### 1. Associated Genes
Apart from BCL10 and MALT1 mentioned in the summaries, CARD14 may interact with additional signaling proteins like:
- **TRAF2 (TNF Receptor Associated Factor 2)**
- **TRAF3 (TNF Receptor Associated Factor 3)**
- **TRAF6 (TNF Receptor Associated Factor 6)**
- **IKK (Inhibitor of NF-kB Kinase)** complex components
These genes are primarily involved in TNF receptor signaling and the modulation of the NF-kB signaling pathway.

### 2. Aging and Age-related Diseases
Research has suggested that CARD14 may be involved in various inflammatory diseases, including:
- **Psoriasis**: Specific mutations in CARD14 have been associated with an increased risk of psoriasis, which is thought to have a link with aging due to the chronic inflammation and immune response implicated in the disease.
- **Aging**: While direct associations may not be extensively established, chronic inflammation (inflammaging) which CARD14 modulation might influence, has been recognized as a contributing factor to age-related diseases such as cardiovascular disease, neurodegenerative disorders, and certain forms of cancer.

### 3. Drug Interactions
Currently, there are no specific drugs directly targeting CARD14; however, drugs that modulate the NF-kB signaling pathway or have anti-inflammatory properties could indirectly affect its action. Classes of drugs involved would include:
- **Corticosteroids**: Known to inhibit NF-kB activity and thus may impact CARD14 mediated pathways.
- **Biologics for autoimmune diseases**: Medications targeting TNF-alpha and IL-17, like monoclonal antibodies (e.g., Etanercept and Secukinumab), could indirectly modulate CARD14-related signaling.

### 4. Pathways and Biological Processes Involved
CARD14 is involved in several critical pathways and biological processes, including:
- **Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling pathway**: Promotes transcription of genes involved in immune responses and inflammation.
- **Cytokine-cytokine receptor interaction**: Plays a role in mediating the inflammatory response via secreted cytokines.
- **Apoptotic signaling**: Protects cells from apoptosis, suggesting a role in cell survival under inflammatory conditions.
- **Regulation of the JNK and p38 MAPK pathways**: Important in responding to stress and inflammation.
- **Cellular response to stress**: Involves signaling pathways that manage cellular responses to cytokines and other stressors.

In summary, CARD14 is an essential participant in the regulation of inflammatory responses and apoptosis, with implications for various diseases, particularly those associated with chronic inflammation and potentially aging processes.