### CD93 Gene Overview

**Gene Symbol:** CD93

**Function and Structure:**  
The CD93 gene encodes a cell-surface glycoprotein that is part of the type I membrane protein family. Initially identified as a myeloid cell-specific marker, it has since been shown to play significant roles beyond its original designation. It is implicated in intercellular adhesion and the clearance of apoptotic cells. The protein has a cytoplasmic tail that interacts with moesin, which is crucial for connecting transmembrane proteins to the cytoskeleton and facilitating cytoskeletal remodeling.

**Protein Interactions:**  
Within its role, CD93 acts as a receptor (or part of a larger receptor complex) for C1q (which is involved in the complement system), mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA). These interactions may facilitate enhanced phagocytosis in monocytes and macrophages, indicating a role in immune response and homeostasis.

### Additional Information

1. **Associated Genes:**  
   CD93 has been implicated in association studies with several other genes, although specific gene pairs or interactions may vary based on the context of studies (e.g., genes involved in immune response). Notable associations could be observed with genes involved in related signaling pathways, such as:
   - **TLR4** (Toll-like receptor 4) – involved in innate immunity.
   - **CD14** – a co-receptor for the detection of pathogens in myeloid cells.
   - **FCRL1** (Fc receptor-like 1) – plays roles in immune signaling and regulation.

2. **Aging and Age-related Diseases:**  
   While direct studies specifically tying CD93 to aging are limited, its roles in immune response and apoptosis may indicate relevance to age-related diseases, such as:
   - **Chronic Inflammation:** Changes in immune function and clearance of apoptotic cells during aging can lead to chronic inflammation, where CD93 could potentially modulate responses.
   - **Cancer:** Inflammatory processes linked with aging can lead to tumor progression, where altered expression of CD93 may contribute.
   - **Cardiovascular Diseases:** Given its associations with myeloid cells and phagocytosis, abnormalities in CD93 function may also relate to cardiovascular complications seen with aging.

3. **Drug Interactions:**  
   There are no widely recognized drugs or specific drug classes that directly target CD93. However, therapeutic agents that modulate immune functions, particularly in macrophage activity or phagocytosis, may indirectly influence CD93 activity. Research into targeted therapies for inflammation might uncover potential interactions.

4. **Pathways and Biological Processes:**  
   CD93 is involved in several biological processes, including:
   - **Immune Response:** It participates in innate immune responses, particularly enhancing phagocytosis and clearance of apoptotic cells, which is pivotal for maintaining immune homeostasis.
   - **Cell Adhesion:** CD93's role in intercellular adhesion is essential for proper immune cell interactions and trafficking.
   - **Endocytosis and Phagocytosis:** Interactions with various ligands enhance the ability of immune cells to internalize microorganisms and apoptotic material.
   - **Complement Activation Pathways:** May play a role in the activation of the complement pathway, particularly in the context of immune complex clearance.

By understanding CD93's functions, interactions, and relevance in health and disease, researchers can better assess its potential as a target for therapeutic intervention in a variety of pathological contexts.