### NUDT14 Gene Overview

**Gene Symbol**: NUDT14  
**Location**: Chromosome 1 (1q42)  
**HGNC ID**: 24089  
**Entrez Gene ID**: 94250  
**Ensembl ID**: ENSG00000152777

### Gene Function

The NUDT14 gene encodes a protein that belongs to the Nudix hydrolase family, characterized by their ability to hydrolyze nucleoside diphosphate derivatives. The primary function of NUDT14 includes the hydrolysis of UDP-glucose to glucose 1-phosphate and UMP, as well as the hydrolysis of ADP-ribose to ribose 5-phosphate and AMP. 

### Known Associations with Other Genes

NUDT14 may be associated with several other genes, particularly those involved in nucleotide metabolism and signaling pathways. Examples include:
- **NUDT2**: Another Nudix hydrolase that functions to hydrolyze various nucleotide substrates.
- **NUDT16**: Shares functional similarities and may have overlapping roles in nucleotide metabolism.

Genetic interactions and co-expression networks may also link NUDT14 to genes involved in cellular stress responses, signaling pathways, and carbohydrate metabolism.

### Age-Related Associations

While direct associations between NUDT14 and aging or age-related diseases are not extensively reported, its involvement in nucleotide metabolism suggests potential implications in cellular aging processes. Altered nucleotide pools can contribute to cellular senescence, DNA damage responses, and the overall metabolic state associated with aging. NUDT14's role in managing nucleotide metabolites could indirectly influence age-related pathologies, such as:
- **Cancer**: Dysregulation of nucleotide metabolism is a common feature in cancer.
- **Neurodegenerative Diseases**: Fluctuations in nucleotide levels can affect neuronal signaling and health.

### Known Drug Interactions

There are currently no specific drugs directly targeting NUDT14 in mainstream therapeutic use. However, compounds that modulate nucleotide metabolism or that interact with hydrolases may indirectly affect its activity. Research into potential small-molecule inhibitors or modulators of Nudix hydrolases is ongoing, which could impact NUDT14 function.

### Pathways and Biological Processes Involved

NUDT14 is involved in several important biological processes, including:
- **Nucleotide Metabolism**: It plays a critical role in the hydrolysis of nucleotide sugars, particularly in the regulation of UDP-glucose levels.
- **Carbohydrate Metabolism**: By producing glucose 1-phosphate, it may influence glycolysis and glycogen metabolism.
- **Signal Transduction**: Through its action on ADP-ribose, it may regulate signaling pathways that rely on ATP metabolites.

**Pathway Associations**:
- **Glycolysis / Gluconeogenesis**: Contributes to the control of glucose levels and energy metabolism.
- **Nucleotide Excision Repair**: Due to its role in hydrolyzing nucleotides that can influence DNA repair processes.
- **Cellular Stress Response**: Involvement in stress signaling via modulation of nucleotide levels that may alter cellular responses to damage.

### Conclusion

The NUDT14 gene encodes an important enzyme in nucleotide metabolism, with potential implications in aging and disease due to its role in managing nucleotide metabolites. While specific drug interactions are not well established, continued research may illuminate further connections and therapeutic implications involving NUDT14 and its related pathways.