### Gene Summary for C9orf78

**Gene Symbol:** C9orf78  
**Location:** Cytosol and nucleoplasm

**Function:**  
C9orf78 is involved in pre-mRNA splicing, particularly by promoting the usage of upstream 3'-splice sites at alternative NAGNAG splice sites. These splice sites consist of alternative acceptor motifs that are separated by only a few nucleotides. The gene may also modulate exon inclusion events and contributes to spliceosomal remodeling, particularly by displacing WBP4 from the SNRNP200 complex. Additionally, it has a role in binding U5 small nuclear RNA (snRNA) and is necessary for proper chromosome segregation. Notably, it is not required for splicing components of shelterin, a complex that protects telomeres.

### 1. Associated Genes
C9orf78 has been associated with various genes involved in splicing, mRNA processing, and chromosome segregation. While specific genes may vary among studies, potential associated genes could include:

- **SNRNP200:** Known for its role in RNA splicing as a component of the spliceosome.
- **WBP4:** A WW domain-containing protein involved in splicing regulation.
- **PRPF proteins:** These are involved in pre-mRNA processing and could be related given the splicing function of C9orf78.

### 2. Aging or Age-Related Diseases
Currently, the literature does not extensively document direct associations of C9orf78 with aging or specific age-related diseases. However, since spliceosomal dysfunction and impaired RNA processing are implicated in various age-related diseases, including some types of cancer and neurodegenerative diseases, it is possible that C9orf78 may have an indirect role. Further research may elucidate its specific contributions to these processes.

### 3. Drug Interactions
As of now, there are no specific drugs or drug classes explicitly documented to interact directly with the C9orf78 gene or its protein product. Its primary role revolves around splicing and RNA processing, which may not have been targeted directly by therapeutic agents up to the present knowledge.

### 4. Pathways and Biological Processes
C9orf78 is involved in the following biological pathways and processes:

- **mRNA Splicing:** It primarily functions in the splicing of pre-mRNA, contributing to the proper processing of mRNA transcripts.
- **Spliceosomal Assembly and Remodeling:** C9orf78 influences the assembly and remodeling of the spliceosome, particularly through its interaction with spliceosomal components such as U5 snRNA and SNRNP200.
- **Cell Division/Chromosome Segregation:** It has a crucial role in ensuring accurate chromosome segregation during cell division, which is fundamental in maintaining genomic stability.

While comprehensive, ongoing research related to C9orf78 may uncover further associations in specific biological pathways and disease states.