### NIFK Gene Overview

**Gene Symbol:** NIFK  
**Location:** Human genome; specific chromosome not mentioned.  
**Function:** The NIFK gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen, which is a well-known marker for cell proliferation. NIFK is believed to play a key role in mitosis and cell cycle progression, likely through its interaction with MKI67 (Ki-67 protein). The encoded protein may also bind RNA, suggesting a possible regulatory role in RNA metabolism during cell division.

### 1. Associated Genes
While the summaries provided do not specifically list other genes associated with NIFK, research has identified potential interactions and co-regulations with multiple genes involved in the cell cycle, chromatin remodeling, and chromosomal integrity. Some relevant genes may include:
- **MKI67**: A major interacting partner given NIFK's role in mitosis.
- Genes involved in mitosis and chromosomal segregation, such as **Bub1** (BUB1 Mitotic Checkpoint Serine/Threonine Kinase), and **CDK1** (Cyclin Dependent Kinase 1).
  
Additional studies may reveal further associations with genes involved in RNA processing or transcriptional regulation.

### 2. Age-related Details
The NIFK gene's role in cell proliferation suggests a potential involvement in aging and age-related diseases. While specific studies focusing directly on NIFK and aging are sparse, here are some implications:
- **Cell Proliferation and Aging**: As cells lose their ability to proliferate effectively with age, proteins involved in mitosis like those encoded by NIFK might play a role in maintaining this balance.
- **Cancer**: Given that NIFK is associated with cell cycle regulation, it may have indirect links to age-related diseases such as cancer, where the dysregulation of cell cycle proteins is a common event.
  
Future research may clarify the gene's specific contributions to aging mechanisms or the pathogenesis of age-related diseases.

### 3. Drug Interactions
As of the latest data, there are no specific drugs or drug classes explicitly listed that interact with NIFK. However, in general:
- **Anticancer drugs**: These may indirectly affect the expression or function of the NIFK gene since NIFK is involved in mitosis and cell proliferation.
- **Cell cycle inhibitors**: Drugs that target the cell cycle machinery, such as CDK inhibitors, could potentially influence pathways involving NIFK.

It's advisable to consult drug interaction databases or recent publications for updates as drug discovery is a constantly evolving field and newer interactions may have emerged.

### 4. Involvement in Pathways and Biological Processes
NIFK is involved in key biological processes related to cell division and the cell cycle, including:
- **Mitosis**: Direct involvement in mitotic progression, functioning alongside proteins like KI67.
- **Cell Cycle Regulation**: Potential role in the regulation of transitions through various phases of the cell cycle, such as G1 to S and G2 to M.
- **Chromosome Organization**: May contribute to the structural integrity of mitotic chromosomes, given its localization during mitosis.
  
In addition to these pathways, NIFK's RNA-binding capability suggests involvement in processes related to gene expression regulation, mRNA stability, and possibly translation during cell proliferation.

To sum up, while the NIFK gene is primarily known for its role in cell cycle regulation through its interactions with mitotic proteins, its broader implications for aging, drug interactions, and molecular pathways are areas of active research. Understanding these dimensions can provide insights into its potential as a therapeutic target or biomarker in diseases related to cell proliferation and aging.