### ELMOD3 Gene Overview

**Gene Symbol:** ELMOD3

**Description:**
The ELMOD3 gene encodes a member of the engulfment and cell motility (ELMOD) family of GTPase-activating proteins that mainly regulate ADP-ribosylation factors (Arf proteins). This gene is characterized by a conserved domain known as the engulfment and cell motility domain.

### 1. Associated Genes:
While the summary provided does not mention specific interacting genes, ELMOD3 could be functionally linked to other genes involved in the GTPase signaling pathway. Some genes potentially associated with ELMOD3 include:

- **ARL2 (ADP-ribosylation factor-like 2):** A known substrate for ELMOD3 as it acts as a GTPase-activating protein (GAP) for ARL2.
- Genes involved in hearing pathways, as ELMOD3 has been implicated in cochlear sensory cell function and nonsyndromic deafness, could also be indirectly associated.

### 2. Aging and Age-related Diseases:
The association of ELMOD3 with age-related conditions revolves mainly around its role in hearing. As humans age, hearing loss becomes prevalent, a condition that can stem from mutations or dysregulation of genes like ELMOD3. Specifically, the allelic variant related to autosomal recessive nonsyndromic deafness-88 indicates the gene's critical function in auditory sensory function and may correlate to increased incidence of age-related hearing loss (presbycusis).

### 3. Drug Interactions:
Currently, there are no specific drugs or drug classes noted in databases for direct interactions with ELMOD3. However, due to its functional existence in signaling pathways, any drugs affecting GTPase activity, cellular motility, or involved in sensory neuron function could indirectly impact the expression and/or function of ELMOD3.

### 4. Pathways and Biological Processes:
ELMOD3 is linked to several biological pathways and processes, including:

- **Regulation of GTPase activity:** ELMOD3 acts primarily as a GTPase-activating protein (GAP) for the ARL2 protein, influencing its activity and downstream cellular processes.
- **Ciliary function:** As the protein has been localized in the stereocilia and kinocilia of hair cells, it likely plays a role in processes like intracellular transport and sensory signal transduction in sensory cells of the cochlea.
- **Cell motility:** The broader ELMOD family is involved in processes related to engulfment, motility, and possibly tissue remodeling during development or in response to injury.

### Summary:
ELMOD3 is an essential gene in hearing function related to cell motility and GTPase regulation. Its mutations are linked to deafness, particularly in the context of embryonic sensory development. Future research could clarify its role in aging processes and potential relationships with diseases beyond hearing impairment.