### GPSM3 Gene Overview

**Gene Symbol:** GPSM3

**Function:** 
GPSM3 (glycogen phosphorylase/serine/threonine-protein phosphatase 1 regulator and G-protein signaling modifier 3) is known to regulate the activity of G(i) alpha proteins, which are involved in various signaling pathways. It is predicted to enable GTPase regulator activity and plays a role in the positive regulation of inflammatory response, including cytokine production and leukocyte chemotaxis.

### Associated Genes
While specific associations beyond those indicated in the summaries may not be readily available, genes that are often considered in relation to GPSM3 due to their involvement in similar pathways include:

- **GNAI2** and **GNAI3:** These are Gαi family members that are directly regulated by GPSM3.
- **IL6 and TNF:** Cytokines that are involved in the inflammatory response, which GPSM3 is implicated in regulating.
- **CXCL8:** A chemokine known to be involved in leukocyte chemotaxis and could be influenced by the pathways related to GPSM3.

### Aging and Age-Related Diseases
Research on GPSM3 and its direct connections to aging or specific age-related diseases is scarce; however, its role in the inflammatory response may implicate it in age-related inflammatory conditions, such as:

- **Chronic Inflammation:** Often observed in aging, which can contribute to various age-related diseases.
- **Neurodegenerative Diseases:** GPSM3 may have a potential role in modulating inflammation in conditions such as Alzheimer's disease, although direct evidence is limited.

### Drug Interactions
Currently, there is no specific drug or drug class directly listed as interacting with GPSM3 in the databases. However, given GPSM3's role in G protein signaling, it might be influenced indirectly by:

- **Anti-inflammatory drugs:** Such as corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs), which target cytokine production and inflammatory pathways.
- **Drugs targeting metabolic pathways:** Medications aimed at modulating inflammatory responses could potentially interact with the pathways in which GPSM3 is involved.

### Pathways and Biological Processes
The GPSM3 gene is involved in several key biological processes and signaling pathways:

- **G-Protein Coupled Receptor (GPCR) Signaling Pathways:** Directly interacts with G(i) proteins which are a class of GPCRs.
- **Inflammatory Response Pathways:** Involved in the positive regulation of processes such as cytokine production and leukocyte chemotaxis.
- **Signal Transduction:** Marginally involved in the signaling cascades originating from receptor activation leading to various cellular responses.

Overall, GPSM3 serves as an essential regulatory protein within the G-protein signaling framework, particularly in contexts related to inflammation, making it a potential target for further research in therapeutic interventions for related diseases.