### NAA10 Gene Overview

**Gene Symbol**: NAA10  
**Description**: The NAA10 gene encodes the N-terminal acetyltransferase 10, which is the catalytic subunit of the N-terminal acetyltransferase A complex. This enzyme is crucial for the process of N-terminal acetylation, a common post-translational modification that regulates various aspects of cell function, including protein stability, localization, and activity.

### 1. Associated Genes
The following genes are closely associated with NAA10 in various biological processes:
- **NAA15**: As mentioned in the summary, it works in conjunction with NAA10 and is important for its function.
- **HIF1A**: The regulation of this gene is affected by acetylation through NAA10.
- **TSC2**: Acetylation by NAA10 stabilizes TSC2, influencing mTOR signaling.
- **MYLK**: Acetylation of this gene product is linked to tumor cell migration.
- **HSPA1A and HSPA1B**: Acetylation enhances their chaperone activity, indicating a potential interaction with heat shock response pathways.
- **HIST1H4A**: This histone variant is also a substrate for NAA10 and is involved in chromatin organization.

### 2. Aging and Age-Related Diseases
NAA10 has implications in aging and age-related diseases:
- **Cancer**: Aberrant regulation of NAA10 activity can influence tumor progression and metastasis due to its role in various cellular pathways, including mTOR signaling, which is known to be altered in age-related diseases and cancers.
- **Neurological disorders**: Since NAA10 is involved in neuronal growth and development, alterations in its function may be linked with neurodegenerative diseases, which are often age-related.
- **Ogden syndrome**: Mutations in NAA10 lead to Ogden syndrome, which can present with developmental delays and other features that might reflect aspects of aging at the cellular level.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly target NAA10 are not well-documented in repositories. However, since it plays functions related to acetylation:
- **Histone deacetylase (HDAC) inhibitors**: These drugs may indirectly affect the activity of NAA10 by influencing the overall acetylation landscape within a cell.
- **Antineoplastic agents**: Given the role of NAA10 in acetylation related to cancer, some cancer therapies could be relevant in terms of their broad impact on acetylation patterns.

### 4. Pathways and Biological Processes
NAA10 is involved in several critical biological processes:
- **N-terminal acetyltransferase activity**: Catalyzes the transfer of acetyl groups to the N-termini of proteins.
- **Protein stabilization**: Affects the stability and functionality of proteins like TSC2 and others involved in cell growth and development.
- **Cell cycle regulation**: Acts as a negative regulator of sister chromatid cohesion during mitosis, which is vital for proper cell division.
- **Hypoxia response**: Through acetylation of HIF1A, it plays a role in cellular responses to low oxygen availability.
- **Regulation of tumor cell migration**: By repressing MYLK, it impacts cellular motility, particularly in tumor contexts.

### Conclusion
NAA10 plays a multifaceted role in cellular regulation through post-translational modifications, affecting processes ranging from protein stability to tumorigenesis. Its involvement in significant pathways points to its potential as a therapeutic target, especially in cancer and other age-related conditions. Further studies may elucidate its role in aging more clearly and uncover more drug interactions and associated genes.