### Overview of SNORD108 Gene

**Gene Symbol**: SNORD108  
**Gene Type**: Non-coding RNA, specifically a small nucleolar RNA (snoRNA)  

SNORD108 is part of the C/D box class of snoRNAs, which are primarily involved in the modification of other RNA molecules, particularly ribosomal RNA (rRNA), by guiding the methylation of specific nucleotides.

### 1. Associated Genes

While specific interactions may vary based on the context (e.g., cellular conditions and types), the following genes are known to be associated indirectly with SNORD108 due to its role in rRNA modification:

- **SERPINB1**: This gene has been associated with certain snoRNA genes, including SNORD108, in studies exploring the regulation of gene expression.
- **RNU2**: Part of the U2 small nuclear RNA (snRNA) family, often works in conjunction with snoRNAs during rRNA processing.
- **RPS genes**: Genes encoding ribosomal proteins, which may be influenced by alterations in rRNA methylation by SNORD108.

### 2. Aging and Age-related Diseases

Research indicates that many snoRNAs, including SNORD108, may play roles in cellular processes that relate to aging. Though specific studies on SNORD108 are limited, snoRNAs in general have been implicated in various age-related phenomena, such as:

- **Cellular Senescence**: Altered expression of snoRNAs may be involved in the regulation of cellular senescence pathways, potentially influencing lifespan.
- **Age-related Diseases**: Dysregulation of snoRNAs, including potential knock-on effects from SNORD108, has been implicated in the pathogenesis of diseases like Alzheimer's and various cancers. However, direct evidence linking SNORD108 to specific age-related diseases remains scarce and suggests an area for further investigation.

### 3. Interactions with Drugs or Drug Classes

As SNORD108 is a small nucleolar RNA and primarily involved in the modification of rRNA, there are no known direct drug interactions specifically targeting SNORD108. However, research into drugs that affect ribosome biogenesis and RNA processing could indirectly influence the activity of SNORD108. Such drugs may include:

- **Antibiotics**: Some antibiotics, such as macrolides or aminoglycosides, affect ribosomal function, which might indirectly alter the roles of snoRNAs.
- **Chemotherapeutic agents**: Drugs that target nucleic acid synthesis or ribosomal function may also impact the functioning of snoRNAs in cancers.

### 4. Pathways and Biological Processes

SNORD108 is involved in several biological processes:

- **rRNA Methylation**: The primary function of SNORD108 involves guiding the methylation of ribosomal RNA, thereby influencing ribosome assembly and function.
- **RNA Processing**: SNORD108 plays a significant role in the biogenesis of ribosomal RNA, essential for the synthesis and maturation of ribosomes.
- **Regulation of Gene Expression**: Through its association with rRNA, this snoRNA contributes to the overall regulation of translation and protein synthesis.

### Summary

In conclusion, SNORD108 is a small nucleolar RNA that plays important roles in rRNA modification and is indirectly linked to other genes involved in ribosome assembly and function. Its implications in aging and age-related diseases remain largely unexplored, and there are currently no direct drug interactions established for this specific snoRNA. Nevertheless, understanding its functions and associations continues to be an important area of research in the fields of molecular biology and genetics.