### GPR87 Gene Overview

**Gene Symbol**: GPR87  
**Location**: Chromosome 3  
**Gene Type**: Protein-coding gene  
**Function**: GPR87 encodes a G protein-coupled receptor (GPCR) which serves as a receptor for lysophosphatidic acid (LPA). The gene has been implicated in signaling pathways related to cell survival, particularly in the context of DNA damage, where it plays a role in the p53/TP53-dependent survival mechanism.

### Associated Genes
GPR87 is located in a cluster with other G protein-coupled receptor genes on chromosome 3; however, explicit associations with specific genes beyond the GPCR cluster may not be highly documented. Genes that are often studied in conjunction with GPR87 due to shared pathways or related conditions include:

- **TP53**: The tumor suppressor gene p53 is known to regulate GPR87, particularly in the context of cellular responses to stress and DNA damage.
- **LPA receptors (EDG family)**: Genes such as EDG2 (LPAR1) may have functional overlaps or regulatory relationships with GPR87 owing to the shared ligand, lysophosphatidic acid.

### Aging and Age-Related Diseases
Research surrounding GPR87 in the context of aging is limited. However, it is noted that:

- Its overexpression has been documented in lung squamous cell carcinoma, which may have associations with age as cancer risk generally increases with advanced age.
- Given its interaction with TP53, which is known for its roles in aging and cellular senescence, GPR87 may indirectly relate to age-associated pathologies through its influence on cell survival in older tissues or in response to genomic stress.

### Drug Interactions
GPR87 has been studied in relation to certain drug interactions primarily through pathways it influences. While specific drugs targeting GPR87 directly may not be prevalent, drugs that alter LPA signaling or act on GPCR pathways could indirectly affect the function of GPR87. These include:

- **Anticancer agents**: Given its association with cancer, agents used for therapeutic purposes in lung cancer may impact GPR87 expression or activity.
- **LPA antagonists**: Research into the signaling cascades involving LPA might lead to Drug classes that can modulate GPCR activity, including small molecule modulators.

### Pathways and Biological Processes
GPR87 is involved in several critical pathways and biological processes, including:

- **GPCR Signaling Pathways**: As a G protein-coupled receptor, GPR87 is integral to various downstream signaling pathways that affect cell survival and proliferation.
- **Cell Survival and Apoptosis Regulation**: The receptor's interaction with LPA and its regulation through p53 influences cellular responses to stress, especially in noting DNA damage repair mechanisms.
- **Cancer-related Pathways**: Its overexpression in squamous cell carcinoma links it to pathways involved in tumorigenesis and cancer progression.
- **Inflammation and Immune response**: GPCRs like GPR87 are often implicated in modulation of inflammatory responses, potentially linking it to various immune pathways.

### Conclusion
GPR87 serves as a vital component in cell signaling, with potential implications in cancer biology and cellular stress responses. While direct research on its role in aging and drug interactions is still in development, it undeniably intersects with pivotal biological processes relevant to health and disease. Further studies could elucidate its full spectrum of biological implications, particularly as they pertain to age-related conditions.