### ADGRF5-AS1 Gene Overview

**Gene Symbol**: ADGRF5-AS1  
**Description**: ADGRF5-AS1 (Adhesion G Protein-Coupled Receptor F5 Antisense RNA 1) is a long non-coding RNA (lncRNA) that is transcribed from the opposite strand of the ADGRF5 gene, which encodes an adhesion GPCR. As a non-coding RNA, ADGRF5-AS1 may play regulatory roles in gene expression, chromatin remodeling, and cellular function.

### 1. Associated Genes 

While specific gene association data for ADGRF5-AS1 may be sparse, the following genes are closely associated or related to its primary gene, **ADGRF5**:

- **ADGRF5**: The primary gene it is antisense to; they are biologically linked in terms of transcriptional regulation.
- **ADGRs (Adhesion GPCRs)**: Genes in the families of adhesion GPCRs may show functional interactions or pathways involving ADGRF5-AS1.
- **miRNA target genes**: Since lncRNAs can serve as sponges for miRNA, any miRNAs that target genes regulated by ADGRF5 may indirectly imply association.

Note: Specific literature detailing other genes significantly associated with ADGRF5-AS1 was limited at the time of knowledge cutoff.

### 2. Aging and Age-Related Diseases

Information specific to aging or age-related diseases linked with ADGRF5-AS1 is not well-documented. However, in the realm of lncRNAs, many are known to affect cellular senescence, apoptosis, and various signaling pathways which can be related to aging. The functional role of ADGRF5-AS1 may need further research to determine specific implications in these contexts. 

Research suggests that lncRNAs can modulate gene expression and may play roles in the pathogenesis of age-related conditions, including:

- Cardiovascular disease
- Neurodegeneration
- Cancer

### 3. Drug Interaction 

As of the latest update, specific information regarding drugs or drug classes directly interacting with ADGRF5-AS1 was not clearly established. However, lncRNAs can influence drug responses and may interact with compounds that modulate gene expression:

- **Antisense oligonucleotides**: These are designed to inhibit lncRNAs, and research in this area could lead to a better understanding of how to target ADGRF5-AS1.
- **Histone deacetylase inhibitors (HDACi)**: Since lncRNAs often play roles in chromatin remodeling, drug classes like HDACi may interact indirectly.

### 4. Pathways and Biological Processes 

ADGRF5-AS1, being a lncRNA, is linked to a variety of pathways and biological processes, which often include:

- **Regulation of gene expression**: It may modulate the expression of the nearby ADGRF5 gene and other target genes through various mechanisms including chromatin remodeling, transcriptional regulation, and interaction with transcription factors.
- **Cell signaling**: lncRNAs can be involved in the signaling processes, particularly in developmental pathways given the adhesion GPCR context.
- **Cell proliferation and differentiation**: Implications in cellular processes such as proliferation and differentiation through the modulation of signaling pathways.

### Conclusion

ADGRF5-AS1 is a long non-coding RNA implicated in various biological processes through its regulatory functions over gene expression. While specific associations with drug interactions, aging, and certain gene pathways may require further research, its potential impact on health, particularly in the context of diseases linked with aging, remains an area of growing interest in genomic studies.