### MIR133A1HG Gene Overview

**Gene Symbol:** MIR133A1HG

**Description:** The MIR133A1HG gene is known as a long non-coding RNA (lncRNA) that serves as a host for the microRNA MIR133A. This gene plays a critical role in regulating gene expression and has been associated with various biological processes, particularly those affecting muscle biology and cardiovascular function.

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### 1. Associated Genes

MIR133A1HG is connected to several other genes, particularly those involved in muscle development and function. These may include, but are not limited to:

- **MIR133A (microRNA)**
- **SERCA2 (Sarcoplasmic Reticulum Ca²⁺ ATPase 2)**
- **MYH7 (Myosin Heavy Chain 7)**
- **PTGIS (Prostaglandin I2 Synthase)**

Additionally, its interactions may influence the expression of various genes involved in cardiovascular health and muscle development.

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### 2. Aging & Age-Related Diseases

Research has indicated a potential relationship between MIR133A1HG and aging processes or age-related diseases, particularly in the context of:

- **Cardiovascular Aging:** Changes in this lncRNA have been implicated in age-related alterations in cardiac function and may contribute to conditions such as heart failure.
- **Skeletal Muscle Aging:** The regulation of muscle-specific genes by MIR133A1HG suggests that it may play a role in muscle degeneration or atrophy associated with aging (sarcopenia).

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### 3. Drug Interactions

Currently, specific drugs or drug classes have not been universally established as direct interactors with MIR133A1HG. However, its involvement in cardiovascular health may suggest a potential for interaction with treatments aimed at:

- **Heart disease:** Statins or other cardioprotective agents may indirectly involve pathways relevant to MIR133A1HG.
- **Antineoplastic agents:** Because of its role in muscle and possibly cancer pathways, further research may explore its interaction with cancer therapies.

Ongoing pharmacogenomic studies may elucidate more detailed interactions in the future.

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### 4. Pathways and Biological Processes

MIR133A1HG is involved in several biological pathways and processes, including:

- **Cardiac muscle contraction:** Through modulating the expression of related microRNAs, it influences heart muscle activity.
- **Skeletal muscle development:** It plays a role in muscle differentiation and regeneration.
- **Regulation of cell proliferation and apoptosis:** Its expression levels may affect tumorigenesis through interactions with cellular growth pathways.
- **Inflammatory responses:** Potentially involved in the modulation of inflammation, linking it to various age-related diseases.

Given its influence over these pathways, MIR133A1HG is a point of interest in research concerning not only muscle and cardiovascular disorders but also broader age-related health implications.

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This gene continues to be under investigation, and ongoing studies may reveal further interactions, especially in the context of aging and drug development. Always refer to the latest literature for updates on these correlations.