### GLYATL3 Gene Overview

**Gene Symbol:** GLYATL3  
**Predicted Function:** The GLYATL3 gene encodes a protein that is predicted to have glycine N-acyltransferase activity, primarily involved in the conjugation of long-chain fatty acyl-CoA thioesters with glycine. This reaction produces long-chain N-(fatty acyl)glycines, which serve as intermediates in the primary fatty acid amide biosynthetic pathway. The protein is predicted to be located in the mitochondrion.

### 1. Associated Genes

While the provided summaries do not mention any specific associated genes, potential association with metabolic pathways could link GLYATL3 with genes involved in fatty acid metabolism, amino acid metabolism, and mitochondrial function. Commonly mentioned associated genes in studies of fatty acid amide biosynthesis and metabolism may include:

- **N-acyltransferases:** Other members of the N-acyltransferase superfamily.
- **Fatty acid synthase (FASN):** Involved in synthesizing fatty acids, which could impact GLYATL3 function.
- **ACOX1 (Acyl-CoA Oxidase 1):** Involved in fatty acid metabolism.

### 2. Aging and Age-Related Diseases

Current research into the role of GLYATL3 in aging or age-related diseases is limited. However, alterations in fatty acid metabolism and mitochondrial function have been linked to age-related conditions such as:

- **Metabolic Syndrome:** Altered pathways involving GLYATL3 could contribute to metabolic disturbances.
- **Neurodegenerative Diseases:** Some studies have highlighted the role of N-acyl amino acids in brain health, suggesting potential implications for diseases like Alzheimer's or Parkinson's.
- **Cardiovascular Diseases:** Given its role in fatty acid metabolism, abnormalities associated with GLYATL3 might contribute to heart disease as lipid metabolism is crucial in the pathophysiology of these conditions.

### 3. Drug Interactions

As of current knowledge (up to October 2023), direct drug interactions with the GLYATL3 gene or its protein product have not been extensively characterized. However, pathways involving fatty acids and amino acids could intersect with various drugs, particularly those targeting metabolic diseases. Classes of drugs that could potentially influence pathways associated with GLYATL3 include:

- **Fatty acid synthase inhibitors:** May impact fatty acid signaling and metabolism.
- **Drug classes that modulate mitochondrial function:** Some anti-diabetic drugs and antioxidants target mitochondrial pathways.

### 4. Pathways and Biological Processes

The GLYATL3 gene is involved in several biological processes and pathways, including:

- **Fatty Acid Metabolism:** GLYATL3 plays a role in the conjugation of fatty acids with amino acids, integral to the metabolism and signaling pathways of lipids.
- **Amino Acid Metabolism:** By transferring acyl groups onto glycine, it is involved in the synthesis of fatty acyl glycine derivatives.
- **Primary Fatty Acid Amide Biosynthetic Pathway:** Essential for the generation of long-chain N-(fatty acyl)glycines, which could have signaling and regulatory functions.

### Summary
The GLYATL3 gene is significant in fatty acid metabolism and has potential links to aging and metabolic disorders. While specific drug interactions remain unclear, research could elucidate its broader impacts on health and disease processes. More studies are necessary to fully understand GLYATL3's functions and its implications in various physiological contexts.