### IL27RA Gene Overview

**Gene Symbol:** IL27RA  
**Location:** Chromosome 19 (19p13.1 in humans)  
**Protein:** Interleukin 27 receptor alpha

**Function:**
The IL27RA gene encodes the alpha subunit of the interleukin 27 (IL-27) receptor. This receptor is part of a complex that includes IL6ST (GP130) and plays a critical role in mediating the signaling pathways elicited by the cytokine IL-27. IL27RA is primarily involved in the differentiation and proliferation of T helper cells, particularly Th1 responses, essential for cell-mediated immunity. The gene also has roles in innate immune responses and neuroprotection through its interaction with humanin.

### Additional Associated Genes
While the summaries provided focus on key interacting partners, the following genes are associated with IL27RA, particularly in immune regulation and signaling pathways:
- **IL6ST** (Interleukin 6 Signal Transducer): Forms a receptor complex with IL27RA.
- **STAT1** and **STAT3**: Transcription factors activated by IL27 signaling.
- **CNTFR** (Ciliary Neurotrophic Factor Receptor): Part of the receptor complex involved in neuroprotection.
- **IL27**: The cytokine for which IL27RA is a receptor.
- **IFNG** (Interferon gamma): Th1 cells primarily produce this cytokine in response to IL27 signaling.

### Details Related to Aging or Age-Related Diseases
Research indicates that IL27RA may play a role in both immunosenescence (the aging of the immune system) and chronic inflammatory diseases, which are more prevalent in older adults. Dysregulation of IL-27 signaling due to age may contribute to impaired immune responses, making older individuals more vulnerable to infections and autoimmune diseases. Further, variations in the IL27RA gene have been studied with regard to their association with conditions like osteoarthritis and certain types of cancers, which are also age-related.

### Drug Interactions
As of 2023, there are no specific drugs directly targeting IL27RA that are widely recognized in clinical use. However, the following classes of agents may interact or influence IL27RA-related pathways indirectly:
- **Cytokine inhibitors**: Such as monoclonal antibodies targeting IL-27 or its receptors in experimental therapies for autoimmune diseases.
- **Immunomodulators**: Drugs that may influence Th1 or Th2 polarization (e.g., corticosteroids).

### Pathways and Biological Processes
IL27RA is involved in several key biological pathways and processes:
- **Cytokine signaling pathways**: Mainly responding to IL-27.
- **Th1 and Th2 cell differentiation**: Regulation of cell-mediated immune responses.
- **STAT signaling pathway**: Activation of STAT1 and STAT3 in response to IL-27.
- **Innate immune response**: Participation in triggering immediate immune reactions.
- **Neuroprotective signaling**: The complex with humanin is involved in neuronal protection.

### Summary
The IL27RA gene plays a critical role in immune system regulation, particularly in Th1 responses and signaling. Its interactions with various cytokines and signaling molecules underscore its importance in both adaptive immunity and potential implications in age-related diseases. Understanding IL27RA's functions and associated pathways can aid in the development of therapeutic strategies targeting immune dysregulation.