### RNF123 Gene Overview

**Gene Symbol**: RNF123  
**Location**: Human Chromosome 17  
**Function**: RNF123 encodes a protein that functions mainly as an E3 ubiquitin-protein ligase, involvement in the regulation of the cell cycle and NF-kappa-B signaling pathway. 

#### 1. Associated Genes
Although the summaries mainly highlight interactions with specific proteins, RNF123 is associated with the following genes:
- **CDKN1B** (Cyclin-dependent kinase inhibitor 1B): Directly regulated by RNF123.
- **NFKB1**: Precursor to subunits of the NF-kappa-B complex.
- **RIG-I** (also known as DDX58): A pattern recognition receptor in the innate immune response.
- **IFIH1**: Another sensor involved in antiviral responses.
- **MAVS** (Mitochondrial antiviral signaling protein): Involved in signal transduction of antiviral signaling pathways. 

#### 2. Aging and Age-Related Diseases
While specific studies linking RNF123 to aging are limited, there are several potential connections:
- **Cancer**: Dysregulation of RNF123’s E3 ligase function can contribute to tumorigenesis by affecting the degradation of proteins like CDKN1B, which plays a role in cell cycle regulation. 
- **Inflammation and Immune Response**: Alterations in RNF123 can impact NF-kappa-B signaling, which is critical in inflammation. Chronic inflammation is a known aspect of aging and age-related diseases.
- **Neurodegenerative Diseases**: Given the role of ubiquitin-proteasome pathways in proteostasis, dysfunction in RNF123 could be implicated in diseases like Alzheimer's or Parkinson's.

#### 3. Drug Interactions
While specific canonical drug interactions with RNF123 are not widely documented, potential platforms for exploration include:
- **Proteasome Inhibitors**: As RNF123 is involved in ubiquitination and proteasomal degradation, the use of proteasome inhibitors (e.g., Bortezomib) could indirectly affect RNF123's function and activity.
- **NF-kappa-B Inhibitors**: Manipulation of the NF-kappa-B signaling pathway may involve drugs that affect RNF123 function or stable interactions with NFKB1.

#### 4. Pathways and Biological Processes
RNF123 is involved in various critical biological processes and pathways:
- **Ubiquitin-Proteasome Pathway**: Acts as a ligase facilitating ubiquitin conjugation to substrates for proteasomal degradation.
- **Cell Cycle Regulation**: Promotes the degradation of CDKN1B, facilitating the transition from the G0/G1 phase of the cell cycle.
- **NF-kappa-B Signaling Pathway**: Regulates immune and inflammatory responses by promoting the maturation of NFKB1.
- **Innate Immune Response**: Inhibits signaling pathways mediated by RIG-I and IFIH1, showcasing its diverse regulatory roles.
- **Transcription Regulation**: Interacts with various transcription factors, influencing gene expression profiles involved in stress responses and inflammation.

### Summary
RNF123 is a multifunctional gene involved in cell cycle regulation, immune response, and inflammatory signaling. Given its role in key regulatory pathways and its potential association with age-related conditions, it presents as a gene of significant interest in cancer research, age-related degenerative diseases, and immune response modulation strategies. Further research may elucidate its full spectrum of interactions and implications in health and disease.