**PKNOX2-AS1 Gene Overview:**

**Gene Symbol:** PKNOX2-AS1  
**Location:** Chromosome 2q31.1  
**Gene Type:** Long non-coding RNA (lncRNA)  
**Function:** As an antisense RNA, PKNOX2-AS1 may play regulatory roles in transcription and gene expression related to its associated genes. It is believed to influence PKNOX2, a gene of interest in developmental processes.

### 1. Associated Genes:
PKNOX2-AS1 has been linked to several genes, primarily related to developmental and regulatory processes. Some associated genes include:

- **PKNOX2 (pre-B-cell leukemia homeobox 2)**: The primary target gene of PKNOX2-AS1, which encodes a transcription factor involved in embryonic development and hematopoiesis.
- **Others**: While specific genes directly influenced by PKNOX2-AS1 may not be exhaustively listed, its regulatory nature could suggest associations with various genes within developmental pathways.

### 2. Aging and Age-related Diseases:
While specific details on PKNOX2-AS1’s direct involvement in aging or age-related diseases may not be extensively documented, lncRNAs have increasingly been recognized for their roles in cellular senescence and age-related diseases. Research indicates that alterations in lncRNA expression levels may correlate with aging processes and conditions such as:

- **Neurodegenerative Disorders**: Given its potential role in cellular signaling, dysregulation of PKNOX2-AS1 may implicate it in diseases such as Alzheimer’s.
- **Cancer**: lncRNAs can affect tumor behavior, possibly linking PKNOX2-AS1 with oncogenic processes and promoting investigation into its contribution to cancer as a function of aging.

### 3. Drug Interactions:
Currently, no specific drugs have been directly documented to interact with PKNOX2-AS1. However, the pathways influenced by the PKNOX2 gene may suggest indirect interactions with a range of pharmacological agents, particularly those targeting developmental pathways or cancer therapies. 

### 4. Pathways and Biological Processes:
PKNOX2-AS1 is involved in several pathways and biological processes:

- **Regulation of Gene Expression**: Functions as a regulatory element by influencing the transcriptional activity of PKNOX2, which plays a role in various developmental pathways.
- **Cellular Development and Differentiation**: Links to processes involved in embryonic development, hematopoiesis, and potentially neurogenesis.
- **Signaling Pathways**: May indirectly affect pathways involved in cell signaling critical to development and disease states, though specific pathways are still being researched.

In summary, PKNOX2-AS1 is a long non-coding RNA associated with the regulation of the PKNOX2 gene and is implicated in essential biological processes that may have a role in development and potentially in age-related diseases, though direct associations remain to be comprehensively outlined.