### NFKBIB Gene Overview

**Gene Symbol**: NFKBIB  
**Location**: Chromosome 14q32.33  

The **NFKBIB** gene encodes the protein inhibitor of nuclear factor kappa B (NF-kB), which is critical in regulating immune response, inflammation, cell proliferation, differentiation, and survival. 

### 1. Associated Genes
While the NCBI and UniProt summaries mention NFKBIA as a key interactor, other associated genes include:
- **NFKB1**: The gene that encodes p50/p105, which are subunits of the NF-κB transcription factor.
- **NFKB2**: Encodes the p52 subunit of NF-κB.
- **IKBKG (also known as NEMO)**: An essential component of the NF-κB signaling pathway, which can enhance the NFKBIB function.
- **MAPK14**: Involved in the pathways activating NF-kB signaling.
- **TNF**: Tumor necrosis factor is known to activate NF-kB and, consequently, the pathway involving NFKBIB.

### 2. Aging and Age-Related Diseases
The NFKBIB gene has been implicated in several aging processes and age-related diseases due to its regulation of inflammation and immune responses. Here are some details:
- **Aging**: Alterations in NF-kB signaling are associated with age-related inflammation (often termed "inflammaging"), leading to chronic diseases typical of older adults.
- **Age-Related Diseases**: Dysregulation of NFKBIB and the NF-κB pathway has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's disease due to inflammatory responses in the brain.
- **Cancer**: The protein's role in regulating NF-kB may contribute to tumor progression and cancer metastasis since chronic inflammation can sustain a tumor-promoting microenvironment.

### 3. Known Drug and Drug Classes
Several drugs and drug classes interact with the NF-κB signaling pathway, indirectly or directly influencing the NFKBIB gene's activity:
- **Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)**: Such as aspirin, which can inhibit NF-κB activation and downregulate inflammatory responses.
- **Corticosteroids**: Used to reduce inflammation, effectively inhibiting NF-kB activity.
- **Antineoplastic agents**: Some chemotherapeutic agents target NF-kB subunits and can influence the degradation of NF-kB inhibitors like NFKBIB.
- **Proteasome inhibitors**: Such as bortezomib, indirectly impacting IκB proteins and subsequently NFKBIB through the blockade of protein degradation pathways.

### 4. Pathways and Biological Processes
The NFKBIB gene plays a significant role in various important biological pathways:
- **NF-kB signaling pathway**: A critical pathway for immune responses, inflammation, cell survival, and proliferation.
- **Cytokine signaling in the immune system**: Modulates responses to pro-inflammatory cytokines like TNF-alpha and IL-1β.
- **Apoptosis regulation**: Through its influence on NF-kB which provides resistance to apoptosis in certain contexts.
- **Viral infections**: Modulates the host response through NF-kB activation in response to viral components.
  
Overall, NFKBIB is essential for controlling NF-kB activity, which has broad implications in immunity, inflammation, and longevity-related processes. Its dysregulation may contribute to various pathologies, particularly in the context of aging and age-associated diseases.