### MTHFD1P1 Gene Overview

**Gene Symbol:** MTHFD1P1

**Description:** MTHFD1P1 is a pseudogene located on chromosome 14. It is related to the MTHFD1 gene, which encodes methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, an enzyme that plays a crucial role in folate metabolism. As a pseudogene, MTHFD1P1 does not produce a functional protein but may have regulatory roles or influence the expression of related genes.

### 1. Associated Genes

While the primary gene associated with MTHFD1P1 is MTHFD1, other possible associations may include genes involved in folate metabolism and methylation processes, such as:
- **MTHFD2**: Another member of the methylenetetrahydrofolate dehydrogenase family.
- **MTHFR**: Methylenetetrahydrofolate reductase, which is critical in the folate metabolic pathway.
- **SHMT1 and SHMT2**: Serine hydroxy methyltransferases involved in serine and glycine metabolism.

### 2. Aging and Age-Related Diseases

While MTHFD1P1 is classified as a pseudogene and may not have direct functions related to aging, the MTHFD family is involved in vital metabolic pathways that can influence cellular health and longevity. Here are some considerations:
- **Folate Metabolism**: Altered folate metabolism is linked to age-related diseases, including cardiovascular diseases and some types of cancer.
- **DNA Repair and Stability**: Variations in folate metabolism can impact DNA synthesis and repair mechanisms, contributing to genomic instability, a hallmark of aging.

### 3. Drug Interactions

There are no specific known drugs interacting with MTHFD1P1 directly due to its status as a pseudogene. However, drugs that target folate metabolism indirectly may have implications:
- **Methotrexate**: An anti-folate drug used in cancer treatment and autoimmune disorders that could impact metabolic pathways associated with MTHFD.
- **Folic acid supplements**: These may indirectly influence pathways where MTHFD1P1 and its functional counterparts participate.

### 4. Pathways and Biological Processes

**Key Pathways:**
- **Folate Metabolism**: MTHFD1P1 is related to pathways involving the metabolism of folate, which is critical for nucleotide synthesis and methylation processes. 
- **One-Carbon Metabolism**: This encompasses pathways where virtually all aspects of methylation, including DNA methylation, are influenced by folate availability.
  
**Biological Processes:**
- **Cellular Response to Folate**: Although MTHFD1P1 is a pseudogene, its associated pathways are crucial for responding to folate levels in cells.
- **Nucleotide Biosynthesis**: MTHFD genes are critical for de novo purine and pyrimidine synthesis.

### Summary

MTHFD1P1 serves as a pseudogene related to the functioning of MTHFD1 and broader folate metabolic pathways. While evidence linking it directly to age-related diseases and drug interactions is limited, its associated biological processes provide essential roles in metabolism and cellular health, which can indirectly influence aging and age-related diseases. Further research may elucidate its potential regulatory functions or contributions to disease processes.