### TDH Gene Overview

**Gene Symbol**: TDH  
**Location**: Human chromosome 7  
**Function**: The TDH gene is related to the enzyme L-threonine 3-dehydrogenase, which is involved in the degradation of L-threonine, generating intermediates for various biochemical pathways. In humans, it appears to be a pseudogene due to significant mutations and structural differences, which result in transcripts encoding truncated, non-functional proteins.

### 1. Associated Genes
While specific records of direct associations with other genes are limited, genes involved in amino acid metabolism, oxidative stress response, or those implicated in pseudogene evolution may show some indirect relationships. Some potential genes to consider include:
- **ALDH** (Aldehyde Dehydrogenase): involved in detoxification and metabolizing aldehydes, contributing to systemic metabolic processes.
- **MTHFR** (Methylenetetrahydrofolate Reductase): involved in folate metabolism, which can have downstream effects on amino acid utilization.

### 2. Aging and Age-Related Diseases
There is no direct and specific research indicating that TDH is linked to aging or particular age-related diseases based purely on the information available. However, as pseudogenes can have regulatory roles or influence their neighboring genes, it's plausible that changes in TDH expression or its transcripts might indirectly impact metabolic pathways related to aging or diseases associated with metabolic dysregulation, such as:
- Neurodegenerative diseases (like Alzheimer’s disease) related to amino acid imbalances.
- Metabolic syndrome or diabetes through amino acid metabolism and associated pathways.

### 3. Drug Interactions
Currently, there is no known association of specific drugs or drug classes with the TDH gene, primarily because it does not encode a functional protein and is classified as a pseudogene. Due to its non-functional nature, pharmacological interactions are not well-documented.

### 4. Pathways and Biological Processes
Although the TDH gene is a pseudogene, it may still be associated with various metabolic pathways indirectly through its sequence homology with functional genes. Possible pathways and biological processes include:
- **Amino Acid Metabolism**: Although the gene itself is non-functional, it belongs to pathways involved in the metabolism of L-threonine.
- **Energy Production**: Processes involving the oxidation of amino acids and linking with energy-producing pathways can be relevant.
- **Cellular Stress Response**: Indirect involvement with cellular stress responses might occur due to alterations in amino acid metabolism potentially influencing stress signaling pathways.

### Summary
The TDH gene is an expressed pseudogene in humans lacking the ability to encode a functional enzyme. While it has potential links to amino acid metabolism and related pathways, further research is necessary to elucidate any significant biological roles, particularly regarding aging or interaction with drugs.