### TDRKH-AS1 Gene Overview

**Gene Symbol:** TDRKH-AS1  
**Location:** The TDRKH-AS1 gene is an antisense long non-coding RNA (lncRNA) that is transcribed from the opposite strand of the TDRKH (tudor domain containing receptor kinase) gene.

#### 1. Associated Genes
TDRKH-AS1 is closely linked to the TDRKH gene. Additional potential associations include:
- **TDRKH:** Since TDRKH-AS1 is an antisense transcript, it is directly related to the TDRKH gene, which encodes a protein involved in the regulation of RNA splicing and various cellular processes.
- Other neighboring lncRNA genes may also be considered, although specific list is often dependent on the tissue and environmental context.

#### 2. Aging and Age-related Diseases
Current research on TDRKH-AS1 in relation to aging or age-related diseases is limited. However, long non-coding RNAs (lncRNAs) have been implicated in various cellular processes, including gene regulation and cellular senescence. Dysregulation of lncRNAs has been linked to:
- **Cancer:** Certain lncRNAs influence cancer progression and metastasis, which can be tied to age-related oncogenesis.
- **Neurodegenerative Diseases:** While specific roles of TDRKH-AS1 in these conditions need further exploration, lncRNAs are candidates for involvement in neurodegenerative mechanisms, particularly regarding changes in gene expression with age.

#### 3. Drug Interactions
As of October 2023, no specific drugs or drug classes have been explicitly linked to TDRKH-AS1 in pharmaceutical databases. However, given its role as a long non-coding RNA, there could be indirect interactions with drugs affecting pathways it influences. Future studies could explore potential therapeutic implications or molecular targets in pharmacology.

#### 4. Pathways and Biological Processes
TDRKH-AS1 is not yet extensively characterized in terms of specific biological pathways. However, lncRNAs like TDRKH-AS1 typically participate in:
- **Gene Regulation:** Long non-coding RNAs can modulate gene expression at various levels, potentially affecting transcription and splicing of associated genes like TDRKH.
- **Cell Cycle and Development:** Given its associations with other genes involved in cell growth and replication, TDRKH-AS1 may play a role in these fundamental biological pathways.

In conclusion, while the TDRKH-AS1 gene is a lesser-known player in the landscape of genetics, especially related to aging and age-related diseases, further exploration of its functional roles and associations may lead to valuable insights in biomedical research.