### SNORD118 Gene Overview

**Gene Symbol:** SNORD118  
**Gene Type:** Small nucleolar RNA (snoRNA) 

SNORD118 is a gene that encodes a small nucleolar RNA known to be involved primarily in the modification of ribosomal RNA (rRNA). This gene is classified as a C/D box snoRNA, which function to guide the 2'-O-methylation of specific nucleotide residues in rRNA and other RNA molecules. Small nucleolar RNAs are typically located in the nucleolus and are not translated into proteins.

### Associated Genes

While specific associations can vary based on expression and functional studies, here are some genes and genetic elements that are generally associated with SNORD118:

- **U3 snoRNA**: Involved in the biogenesis of ribosomes, as it synthesizes rRNA.
- **Other C/D box snoRNA genes**: Such as SNORD2, SNORD3, etc., which also participate in rRNA modification processes.
- **Genes involved in ribosome biogenesis and function**: Including but not limited to RPL (Ribosomal Protein L) genes and other snoRNA-associated proteins.

### Aging and Age-Related Diseases

Research surrounding snoRNAs, including SNORD118, has linked various small nucleolar RNAs to cellular aging and age-related diseases, particularly those involving the ribosome's function and stability. Specific details concerning SNORD118 itself in aging are limited; however, altered expression of snoRNA has been observed in various age-related conditions:

- **Neurodegenerative diseases**: Changes in snoRNA expression can correlate with diseases like Alzheimer's.
- **Cancer**: Some studies point to the deregulation of snoRNA, influencing cellular proliferation and apoptosis, which may explain the connection to cancer development.

### Drug Interactions

Currently, there are no specific drugs or drug classes documented in the literature that directly interact with the SNORD118 gene. However, the research on snoRNA-targeting therapies is an emerging field, particularly for cancers and other diseases where RNA modifications play a crucial role in disease pathways.

### Pathways and Biological Processes

1. **Ribosome Biogenesis**: SNORD118 plays a critical role in the processing and modification of rRNA, which is fundamental for the assembly and maturation of ribosomes.
2. **rRNA Methylation**: As a C/D box snoRNA, it participates in the methylation of specific rRNA nucleotide positions that are crucial for rRNA functionality.
3. **Cell Cycle and Growth**: By influencing the efficiency of protein synthesis through ribosome modulation, SNORD118 might indirectly impact cell cycle regulation and metabolic processes linked to cell growth.
4. **Nuclear RNA Processing**: It may also have roles in various nuclear RNA processes, contributing to the overall complexity of RNA regulation within the nucleus.

Overall, the understanding of SNORD118 remains dynamic, and its implications in health and disease continue to be uncovered through ongoing research.