### EML3 Gene Overview

**Gene Symbol:** EML3  
**Location:** Human chromosome 8

**Function:**  
The EML3 gene encodes an evolutionarily conserved protein involved in the regulation of microtubule dynamics, especially during mitosis. EML3 has been predicted to possess microtubule binding activity and is crucial for processes such as mitotic spindle assembly and the congression of chromosomes during the metaphase of cell division. It plays a pivotal role by recruiting the HAUS augmin-like complex and TUBG1 to pre-existing microtubules, which facilitates microtubule-based nucleation necessary for chromosome alignment and separation.

### 1. Associated Genes
While the summaries do not enumerate specific associated genes, EML3 is typically linked with several other genes implicated in mitotic processes, such as:

- **TUBG1**: Involved in microtubule nucleation.
- **HAUS complexes**: As part of the augmin complex, responsible for microtubule amplification.
- Genes related to spindle assembly checkpoints (SACs), such as those encoding kinases and phosphatases that regulate spindle function and chromosome alignment (e.g., **MPS1**).

### 2. Aging and Age-related Diseases
Research into EML3 has not conclusively linked it directly to aging or age-related diseases; however, its critical role in cell division suggests that improper function could contribute to age-related cellular dysfunctions like aneuploidy, which is frequently observed in cancer cells. Abnormal mitotic processes can lead to genomic instability, a significant characteristic of aging and various age-related diseases, including cancer.

### 3. Drug Interactions
Currently, specific drugs that interact explicitly with EML3 are not well-characterized in public databases. However, given its role in cell division:

- **Anti-mitotic drugs** such as paclitaxel (Taxol), which stabilize microtubules, may indirectly impact EML3-associated processes.
- **Chemotherapeutic agents** targeting spindle assembly and cell cycle checkpoints might have implications for the pathways EML3 influences.

### 4. Pathways and Biological Processes
EML3 is involved in several critical biological pathways and processes:

- **Mitotic spindle assembly and function**: Regulating the proper formation and attachment of microtubules to kinetochores during cell division.
- **Chromosome congression**: Ensuring that chromosomes align correctly at the metaphase plate before anaphase.
- **Microtubule nucleation and stabilization**: Engaging with augmented complexes to increase the number of microtubules necessary for effective cellular architecture during mitosis.
- **Cell cycle regulation**: Influencing events associated with the progression through cell division checkpoints.

### Conclusion
The EML3 gene is a fundamental player in the meticulous orchestration of cell division with implications that extend into understanding cellular aging and the onset of age-related viabilities such as cancer. Continued research may elucidate further interactions with drugs and pathways, presenting potential therapeutic avenues in diseases arising from mitotic defects.