### SNORD115-17 Gene Overview

**Gene Symbol:** SNORD115-17

**Summary:** SNORD115-17 is part of the C/D box small nucleolar RNA (snoRNA) family implicated in the modification of ribosomal RNA (rRNA). These snoRNAs are predominantly located within the nucleolus and play vital roles in guiding post-transcriptional modifications, such as 2'-O-methylation of rRNA, which is essential for ribosome function and biogenesis.

### 1. Associated Genes
- **SNORD115**: As a member of the SNORD115 family (which includes multiple snoRNA genes), SNORD115-17 is linked to other members, particularly SNORD115-1 through SNORD115-12. 
- **Other Related Genes**: The gene has indirect associations with other aspects of RNA processing and snoRNA families like the SNORD49 and SNORD78 gene clusters, although these do not directly encode snoRNAs related to the same functions.
- **C/D Box snoRNAs**: These include several others involved in rRNA modification.

### 2. Aging and Age-Related Diseases
- **Neurological Disorders**: Research indicates that dysregulation of snoRNAs, including those in the SNORD115 family, may be connected to age-related neurological conditions such as Prader-Willi Syndrome, which is associated with imprinting defects on chromosome 15.
- **Cancer**: Some studies suggest a regulatory role of snoRNAs in cancer that may relate to aging, although specific age-related pathways are still under investigation.
- **Cellular Senescence**: There is ongoing research into the role of various snoRNAs in cellular aging processes and senescence, as these RNA species may influence ribosome biogenesis which is crucial in maintaining cellular homeostasis.

### 3. Drug Interactions 
Currently, there are no specific drugs or drug classes documented to interact directly with SNORD115-17. However, drugs influencing general RNA processing or targeting pathways involved in rRNA modifications could potentially have indirect effects. Further research might reveal therapeutic developments targeting these pathways in age-related diseases.

### 4. Pathways and Biological Processes
- **Ribosome Biogenesis**: SNORD115-17 is involved in modifications vital for the maturation and function of rRNA, thereby directly impacting ribosomal assembly.
- **Pre-rRNA Processing**: The gene plays an important role in the methylation and processing of pre-rRNA into mature forms necessary for ribosomal function.
- **Gene Regulation**: There is some evidence to suggest that snoRNAs can regulate gene expression, potentially influencing developmental processes and cellular function.

Overall, while SNORD115-17 is primarily known for its function in ribosomal RNA modification, its associations with aging, neurological disorders, and biological pathways underscore its biological significance. Continued research may elucidate further roles in health and disease.