### ABCD3 Gene Overview:

- **Gene Symbol**: ABCD3
- **Type**: Protein-coding gene
- **Location**: Located on chromosome 1 in humans (1p32.1).
- **Function**: Encodes a member of the ATP-binding cassette (ABC) transporter family, specifically involved in the transport of long-chain fatty acids and other molecules into peroxisomes for degradation through β-oxidation. 

### Additional Information:

1. **Associated Genes**: 
   - **ABCD1** and **ABCD2**: Other members of the ALD subfamily involved in peroxisomal transport of fatty acids.
   - **Pex Genes (e.g., PEX5, PEX6)**: Involved in peroxisome biogenesis and function, often studied in relation to disorders like Zellweger syndrome.
   - **FAT/CD36 (Fatty Acid Translocase)**: Interacts with fatty acid metabolism processes, possibly including transport functions mentioned for ABCD3.

2. **Aging and Age-Related Diseases**: 
   - Mutations in ABCD3 have been linked to Zellweger syndrome, which is also associated with premature aging features, affecting cognitive function and life expectancy. Other peroxisomal disorders may have implications for age-related cellular dysfunction due to impaired fatty acid metabolism, which can further relate to age-related diseases such as neurodegeneration, metabolic syndrome, and cardiovascular diseases.
   - The role of fatty acid metabolism in aging-related processes highlights the potential impact of ABCD3 on age-related metabolic dysfunction.

3. **Drug Interactions**: 
   - **Fibrates (e.g., Fenofibrate, Ciprofibrate)**: These drugs are used to lower triglyceride levels and may affect the function of peroxisomal enzymes and transporters, including ABCD3.
   - **Statins**: While primarily targeting cholesterol synthesis, some evidence suggests they might influence peroxisomal functions indirectly through altered lipid metabolism.

4. **Pathways and Biological Processes**:
   - **Peroxisome Pathway**: ABCD3 plays a significant role in the transport of long-chain fatty acyl-CoAs into peroxisomes, crucial for β-oxidation and lipid metabolism.
   - **Fatty Acid Metabolism**: Engaged in the metabolic processes related to fatty acryl-CoA transport, degradation, and biosynthesis of fatty acids.
   - **Cellular Response to Stress**: Involved in the detoxification processes within cells, particularly through the regulation of fatty acid levels.
   - **Bile Acid Metabolism**: Helps transport bile acids, which have roles in lipid digestion and absorption.

Through these functions, ABCD3 is central to various metabolic pathways, with significant implications for health, aging, and disease. Understanding its mechanisms can provide insights into potential therapeutic targets for diseases linked to peroxisomal dysfunction.