**Gene Overview: ARHGAP26-AS1**

**Gene Symbol:** ARHGAP26-AS1  
**Type:** Antisense RNA  
**Location:** Chromosome band 22q13.1  

### 1. Associated Genes
While the primary focus on ARHGAP26-AS1 is as an antisense RNA, it is known to be associated with several other genes:

- **ARHGAP26:** This gene is located near ARHGAP26-AS1 and is involved in the regulation of the Rho GTPase signaling pathway, which is important for various cellular processes, including cell migration and cytoskeletal dynamics.
- **ARHGAP21:** Another Rho GTPase-activating protein that is related in function and potentially co-regulated with ARHGAP26-AS1 due to their proximity on the chromosome.
- **Other nearby genes:** The genomic region may also interact with neighboring genes based on broader regulatory mechanisms common among lncRNAs and their sense counterparts.

### 2. Aging and Age-Related Diseases
There is emerging evidence linking certain long non-coding RNAs (lncRNAs), including ARHGAP26-AS1, to aging and various age-related diseases. While specific studies on ARHGAP26-AS1 may be limited, lncRNAs often play roles in:

- **Cellular senescence:** Altered lncRNA expression levels have been noted in senescent cells.
- **Cancer:** Many lncRNAs are dysregulated in various cancers, and since ARHGAP26-AS1 is associated with ARHGAP26, which has roles in cell signaling related to proliferation, this may extend to cancer biology.
- **Neurodegenerative diseases:** Some lncRNAs have been implicated in the pathology of neurodegeneration, an area worth exploring for ARHGAP26-AS1 connections.

### 3. Drug or Drug Classes Interacting with ARHGAP26-AS1
As of the latest updates, there are no specific drugs or drug classes explicitly noted to interact with ARHGAP26-AS1. However, given the gene's involvement with ARHGAP26 in cellular signaling processes, broader investigations into Rho GTPase modulators could be relevant since these can indirectly affect pathways linked to ARHGAP26-AS1.

### 4. Pathways and Biological Processes
ARHGAP26-AS1 is thought to be involved in several biological processes and pathways through its regulation of neighboring genes like ARHGAP26. Some relevant pathways include:

- **Rho GTPase signaling:** This pathway regulates various cellular functions, including cytoskeletal organization, migration, and proliferation.
- **Cellular response to stress:** lncRNAs are often involved in stress responses, including oxidative stress which can influence aging and disease.
- **Regulation of gene expression:** As an antisense RNA, ARHGAP26-AS1 may play a role in modulating the expression of ARHGAP26 and potentially downstream target genes through mechanisms such as RNA-RNA interactions.

In summary, ARHGAP26-AS1 is a long non-coding RNA that is intrinsically linked to processes governed by its coding neighbor, ARHGAP26. Although research on its specific roles is still developing, its potential implications in aging, disease, and gene regulation are significant. Further studies are needed to elucidate its precise functions and interactions in various biological contexts.