### NAA25 Gene Overview

**Gene Symbol:** NAA25  
**Function:** The NAA25 gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B (NatB) complex, which is responsible for the acetylation of N-terminal methionine residues followed by acidic amino acids (Asp, Glu) or Asn/Gln. This modification is critical for protein stability, localization, and function.

### 1. Associated Genes
While the NAA25 gene is primarily associated with the NatB complex, there are several other genes encoding components of this complex. These include:

- **NAA20:** The catalytic subunit of the NatB complex.
- **NAA10:** Part of the NAT complex, associated with NatA and involved in the acetylation of methionine residues.
- **NAA30:** Another member of the NAA gene family with a role in N-terminal acetylation.

### 2. Aging and Age-related Diseases
While specific studies directly linking NAA25 to aging or age-related diseases are limited, N-terminal acetylation is generally acknowledged to play a role in maintaining protein homeostasis, which is crucial for cellular function and longevity. Dysregulation of acetylation processes has been implicated in various age-related diseases, particularly neurodegenerative disorders, where the accumulation of damaged proteins is evident. Further research may reveal more specific roles of NAA25 in these contexts.

### 3. Drug Interactions
There is currently no well-established list of drugs or drug classes that directly interact with the NAA25 gene or its protein product, NAA25. However, since N-terminal acetylation processes can impact protein interactions and stability, it is possible that drugs targeting protein acetylation may have indirect effects on NAA25 activity. Research in the field of epigenetics and protein modification may present future opportunities for therapeutic targeting.

### 4. Pathways and Biological Processes
NAA25 is involved in several key biological processes and molecular pathways, including:

- **Protein Acetylation:** Specifically, it is involved in the N-terminal acetylation process of newly synthesized proteins by the NatB complex, which affects various cellular functions.
- **Cell Cycle Regulation:** Preliminary evidence suggests that NAA25 may participate in normal cell cycle progression, potentially implicating it in processes such as cellular differentiation and proliferation.
- **Regulation of Protein Stability:** Through its role in acetylation, NAA25 influences the stability and degradation pathways of proteins, affecting overall cellular homeostasis.
- **Response to Stress:** Potentially involved in cellular response mechanisms to stress conditions that can lead to altered protein synthesis.

### Summary
The NAA25 gene serves an important role in the N-terminal acetylation of proteins, which is critical for a variety of cellular processes. While more research is needed to explore its implications in aging and drug interactions, its integration in fundamental biological processes underlines its significance in both normal cellular functions and potential pathologies.