### Overview of RPSAP65 Gene

**Gene Symbol:** RPSAP65  
**Function:** RPSAP65 (Ribosomal Protein S5 Associated Protein 65) is a non-coding RNA gene primarily involved in ribosome biogenesis and potentially in the regulation of gene expression. It is thought to associate with ribosomal proteins, which may enhance the assembly of ribosomal subunits.

### 1. Associated Genes

While specific associations of RPSAP65 with other genes may not be comprehensively documented, it is important to note that genes involved in ribosome biogenesis are often interconnected. Some genes that may be associated include:
- **RPS5:** A component of the ribosomal protein S5, which interacts with RPSAP65.
- **RPL5/RPL11:** Ribosomal proteins that play roles in the assembly of ribosomal subunits and may function closely with RPSAP65.
- Genes related to the regulation of RNA polymerase and those involved in nucleolar functions could also have indirect associations.

### 2. Aging and Age-Related Diseases

Research into the RPSAP65 gene's role in aging is limited. However, non-coding RNAs have been increasingly implicated in the regulation of cellular processes related to aging, including inflammation and cellular senescence. Potential age-related implications could arise from:
- Dysregulation of ribosome biogenesis leading to impaired protein synthesis, which has been linked to age-related phenotypes.
- Alterations in the expression of RPSAP65 might impact cellular stress responses and inflammatory pathways, elements that frequently change with age and contribute to various age-related diseases (e.g., neurodegeneration, cancer).

### 3. Drug Interactions

Currently, there are no well-documented drugs or drug classes known specifically to interact with RPSAP65. However, ribosome biogenesis and related pathways are often targeted in various therapeutic strategies:
- **Antibiotics (e.g., aminoglycosides, macrolides):** These drugs interact with ribosomal machinery, which may indirectly influence pathways associated with RPSAP65.
- **Cancer therapeutics:** Drugs targeting the dysregulated ribosomal biogenesis often serve as a focal point in cancer treatments, which may suggest an indirect relationship through cellular pathways.

### 4. Pathways and Biological Processes

RPSAP65 is primarily implicated in several key biological processes:
- **Ribosome biogenesis:** It plays a role in the assembly and maturation of ribosomal RNA and proteins into functional ribosomal units.
- **Gene expression regulation:** As a non-coding RNA, RPSAP65 may influence mRNA stability and translation efficiency.
- **Cellular stress response:** Involved in managing cellular stress response mechanisms, potentially linking to repair and survival pathways in various cellular contexts.

In summary, while investigations specifically focusing on RPSAP65 may be limited, its role in ribosome biogenesis and potential contributions to cellular processes in aging and disease highlight its importance in cellular function. More extensive studies may reveal deeper insights into its associations and implications in health and disease.