### RAE1 Gene Overview

**Gene Symbol**: RAE1  
**Synonyms**: RAE1-like, RAE1L  

#### Core Functions:
The RAE1 gene encodes a protein that plays a significant role in nucleocytoplasmic transport and RNA export. It is homologous to yeast Rae1 and is characterized by the presence of four WD40 motifs, indicating functional versatility. The protein is localized in the nucleoplasm, near the nuclear rim, and forms meshwork-like structures in the cytoplasm, suggesting its involvement in cytoskeletal interactions and mRNA transport.

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### 1. Associated Genes:
In addition to the relationships with the **Gle2** gene from **Saccharomyces cerevisiae**, RAE1 has associations with the following genes:

- **NXF1 (Nuclear RNA Export Factor 1)**: Involved in mRNA export processes.
- **YB1 (Y-box binding protein 1)**: Known to bind mRNA and influence RNA stability.
- **CINAP (Cytokinesis-related protein)**: Involved in the cell cycle and may have interactions due to mRNA processing functions.
- **KIF5 (Kinesin Family Member 5)**: A motor protein that interacts with RAE1 in mRNA transport along microtubules.

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### 2. Aging and Age-Related Diseases:
- **RNA Transport and Aging**: Dysregulation of RNA transport mechanisms, which involve proteins such as RAE1, has been linked to aging and age-related disorders, including neurodegenerative diseases and cancers, where impaired mRNA localization can lead to accumulation of defective RNAs and proteins.
- **Cell Cycle Regulation**: Given RAE1's role in mitotic spindle formation, changes in its function could impact cellular aging by affecting normal cell division and genomic stability.
- **Cancer**: Alterations in RAE1 expression levels have been implicated in cancer biology, which is prevalent in aging populations, warranting further investigation into how age-related changes in nuclear transport proteins may contribute to tumorigenesis.

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### 3. Drug Interactions:
As of the latest data, there are no specific drugs or drug classes widely known to directly target RAE1. However, compounds involved in RNA processing or cytoskeleton modulation might indirectly influence RAE1's activity, particularly in cellular contexts like:

- **Antineoplastics**, which could affect signaling pathways linked to RAE1 function.
- **Antibiotics** such as actinomycin D, which disrupts RNA synthesis, may affect mRNA export mechanisms involving RAE1 indirectly.

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### 4. Pathways and Biological Processes:
RAE1 is involved in several biological pathways and processes:

- **Nucleocytoplasmic transport**: Facilitating the export of mRNA and ribonucleoprotein particles (mRNPs) from the nucleus to the cytoplasm.
- **Mitotic spindle assembly**: Playing a role in organizing the mitotic spindle during cell division.
- **Cell Cycle Regulation**: Potential involvement in checkpoints and cellular transitions relevant for timely cell division.
- **RNA Metabolism**: Including mRNA stability, localization, and export.

RAE1 has also been linked to pathways involving **RNA transport**, **cell-cycle progression**, **mRNA binding**, and **cytoskeletal interactions**.

In conclusion, the RAE1 gene plays a multifaceted role in cellular processes with implications in both normal aging and age-related pathologies. Further studies could provide deeper insights into potential therapeutic avenues targeting RAE1-pathways in diseases.