### CCDC115 Gene Overview
The **CCDC115** (coiled-coil domain containing 115) gene encodes a protein that plays a significant role in cellular processes, particularly related to the endoplasmic reticulum (ER) and Golgi apparatus.

### 1. Associated Genes
While the summaries you provided mention Vma22p in yeast, other notable genes associated with **CCDC115** include:

- **V-ATPase subunits**: As an accessory component of the V-ATPase, CCDC115 may interact functionally with various subunits of the vacuolar ATPase complex, which are crucial for proton transport and lysosomal acidification.
- **HIF1A (Hypoxia-Inducible Factor 1 Alpha)**: Given its role in iron homeostasis and subsequent regulation of HIF1A hydroxylation, CCDC115 can affect the expression and function of genes under hypoxic conditions.
- **Genes involved in glycosylation**: As defects in CCDC115 are linked to congenital disorders of glycosylation (CDG), it may be related functionally or through pathological mechanisms to genes involved in glycoprotein synthesis and modification, such as those encoding glycosyltransferases or oligosaccharyltransferases.

### 2. Aging and Age-Related Diseases
While specific studies targeting CCDC115 in the context of aging or age-related diseases are limited, its involvement in iron metabolism and cellular stress responses might imply roles in:

- **Neurodegenerative diseases**: Dysregulation of iron homeostasis has been implicated in several neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease.
- **Age-related metabolic syndromes**: Alterations in glycosylation due to dysfunction of CCDC115 may impact numerous metabolic pathways, potentially contributing to age-related metabolic disorders.

### 3. Drug Interactions
Currently, direct drug interactions specifically targeting CCDC115 aren't extensively documented in literature. However, given its role in intracellular iron homeostasis and lysosomal function, there may be indirect interactions with:

- **Iron chelators**: Drugs that modulate iron metabolism, like deferoxamine, might indirectly influence the function of CCDC115 by altering the cellular iron landscape.
- **Lysosomal modulators**: Compounds that affect lysosomal function or promote autophagy could be related to the pathways influenced by CCDC115.

### 4. Pathways and Biological Processes
CCDC115 is involved in several key biological processes and pathways:

- **Proton transport**: CCDC115 is an accessory to the V-ATPase complex, aiding in proton gradients necessary for various cellular functions.
- **Endolysosomal acidification**: It contributes to maintaining the acidic environment of the endolysosomal system, essential for proteolytic activities and metabolic processes.
- **Iron metabolism**: It triggers the activity of Fe²⁺ prolyl hydroxylase (PHD) enzymes crucial for iron homeostasis, influencing HIF1A activity.
- **Glycosylation pathways**: As defects in CCDC115 lead to congenital disorders of glycosylation (CDG), it plays an important role in protein modification pathways.

In summary, the CCDC115 gene is integral to various cellular functions, with potential implications in aging, age-related diseases, drug interactions, and key biological processes, particularly involving iron homeostasis and glycosylation. Further studies will likely shed more light on its comprehensive roles and therapeutic potentials.