### CCDC146 Gene Overview

The **CCDC146** gene (Coiled-Coil Domain Containing 146) encodes a protein that is implicated in functions related to the centrioles and the centrosome, structural components critical for cell division and organization.

#### 1. Associated Genes
While the summaries provided do not specifically list any associated genes, in biological research, several genes may often be co-expressed or interact with CCDC146. Some genes involved in centriole and centrosome functions that could potentially be associated include:

- **CEP135**: Centrobin, which is involved in centriole biogenesis.
- **PCM1**: Pericentriolar Material 1, which is also essential for centriole structure and function.
- **ASPM**: Abnormal Spindle Microtubule Assembly, associated with spindle pole organization.
- **KIFC1**: Kinesin Family Member C1, a motor protein involved in mitotic spindle function.

#### 2. Aging and Age-Related Diseases
Although the specific role of CCDC146 in aging or age-related diseases has not been concretely established, its involvement in centriole and centrosome functions suggests potential implications in age-related cellular processes such as:

- **Cell Division**: As cellular regeneration slows with age, disturbances in centriole function may contribute to cells entering senescence or malfunction.
- **Cancer**: Defects in centrosome regulation and function are implicated in tumorigenesis and cancer progression. Abnormalities in genes like CCDC146 that are vital for centriole integrity could be a contributing factor in age-related increase in cancer incidence.

#### 3. Drug Interactions
Currently, specific interactions between CCDC146 and drugs or drug classes have not been widely documented in the literature. However, any investigational compounds targeting centrosomal functions or proteins in related pathways may indirectly influence the activity of proteins such as CCDC146. Many drugs used for cancer treatment target pathways regulated by centrosomal integrity.

#### 4. Pathways and Biological Processes
CCDC146 may be involved in several important biological processes and pathways, including:

- **Centrosome Cycle**: It plays a crucial role in the life cycle of centrosomes, ensuring proper duplication and functioning of the spindle apparatus during cell division.
- **Mitotic Spindle Organization**: The protein is likely important in organizing and stabilizing microtubules, which are essential for chromosome segregation during mitosis.
- **Ciliogenesis**: Given its localization at the centriole, CCDC146 may also be involved in the formation of cilia, structures that have roles in various signaling pathways and cellular responses.

Overall, while more specific functional insights into CCDC146 remain to be clarified, its association with the centriole suggests critical roles in cell division, potential implications for cancer, and cellular aging processes. Further research will be necessary to fully elucidate its functions and interactions within biological systems.