### PELI1 Gene Overview
**Gene Symbol:** PELI1  
**Function:** PELI1 functions as an E3 ubiquitin ligase, which facilitates the attachment of ubiquitin proteins to target substrates, thereby regulating their stability and activity. 

### Associated Genes
While the summaries mentioned specific interactions with IRAK1, RIPK3, and RIPK1, PELI1 may also interact with the following genes:

- **TNF (Tumor Necrosis Factor):** Involved in inflammatory responses.
- **IKBKG (IKB kinase gamma):** Integral in NF-kB signaling.
- **TRAF6 (TNF receptor-associated factor 6):** Involved in mediating signals from various receptors, including TLRs and IL-1 receptors.

### Aging and Age-Related Diseases
Current research into the role of PELI1 in aging and age-related diseases is limited. However, its involvement in inflammation and immune regulation suggests potential implications:

- **Inflammatory Disorders:** As an activator of NF-kB and a modulator of inflammatory signaling pathways, PELI1 may be implicated in age-related chronic inflammatory conditions, such as arthritis or atherosclerosis.
- **Immune Function:** Changes in PELI1 expression or activity could affect immune system regulation with age, possibly impacting susceptibility to infections and age-related immune decline (immunosenescence).
  
### Drug Interactions
While no specific drugs are universally recognized for direct interaction with PELI1, several drug classes that target inflammation or immune responses may indirectly influence PELI1 activity:

- **Corticosteroids:** Known to modulate inflammatory pathways.
- **Non-steroidal anti-inflammatory drugs (NSAIDs):** Could influence signaling pathways related to PELI1 function.
- **Biologics targeting TNF:** May impact downstream signaling pathways involving PELI1.

### Pathways and Biological Processes
PELI1 is involved in various critical pathways, particularly related to immune response and cytokine signaling:

1. **Toll-like Receptor (TLR) Signaling Pathway:** PELI1 modulates signals initiated by TLRs, which are pivotal for innate immunity.
2. **Interleukin-1 (IL-1) Signaling Pathway:** This pathway is related to inflammation and cell signaling that PELI1 participates in by regulating the degradation of proteins involved in inflammatory responses.
3. **Necroptotic Pathway Regulation:** PELI1 is involved in the modulation of necroptosis, a programmed form of necrosis which has implications in various diseases, including neurodegenerative disorders.
4. **Ubiquitin-Proteasome Pathway:** Through its E3 ligase activity, PELI1 plays a critical role in protein stability and degradation mediated by ubiquitination.

### Summary
The PELI1 gene is a crucial regulator of various signaling pathways, particularly related to inflammation and immune responses. Its functions have implications in aging, chronic diseases, and potential therapeutic targets, although more research is needed to fully elucidate its role in age-related conditions and specific pharmacological interactions.