### WFDC10A Gene Overview

**Gene Symbol:** WFDC10A  
**Location:** Chromosome 20q12-q13

#### General Description
The WFDC10A gene encodes a protein belonging to the WFDC family, characterized by the presence of the WAP-type four-disulfide core domain. This domain is noted for its eight cysteine residues that form four disulfide bonds, contributing to the protein's structural integrity and function as a protease inhibitor.

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### 1. Associated Genes
While the specific database summaries for WFDC10A do not list direct associations with other genes, members of the WFDC gene family, including WFDC1, WFDC2, WFDC3, and others in the telomeric cluster on chromosome 20q, are relevant. Furthermore, it has been noted that several genes within this locus may share regulatory elements or functional pathways.

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### 2. Aging and Age-Related Disease Associations
Research involving members of the WFDC family, including WFDC10A, has suggested a possible involvement in aging processes and related diseases. Notable points include:

- **Cancer:** Some studies have indicated that WFDC gene products may play a role in tumor suppression, although specific direct evidence for WFDC10A is limited.
- **Inflammation and Aging:** The role of protease inhibitors in modulating inflammation suggests that WFDC10A could potentially influence age-related inflammatory pathways, impacting conditions such as arthritis or other chronic diseases.

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### 3. Drug Interactions
Currently, there are no specific drugs or drug classes explicitly known to interact directly with WFDC10A. However, given its role as a protease inhibitor, it may indirectly affect various pathways influenced by proteolytic activity, which could imply interactions with therapies targeting inflammatory or protease activity.

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### 4. Pathways and Biological Processes
The WFDC10A gene is involved in several critical biological processes:

- **Protease Inhibition:** As a member of the WFDC domain family, its primary function includes the inhibition of proteases, which is essential in regulating various physiological processes and maintaining cellular homeostasis.
- **Inflammatory Response:** WFDC proteins often play roles in modulating inflammation, either by directly inhibiting inflammatory mediators or by participating in signaling pathways that regulate immune responses.
- **Tissue Development and Homeostasis:** WFDC10A may also have implications in tissue homeostasis and development given its ubiquitous expression patterns in various tissues.

Overall, while specific functional studies on WFDC10A are limited, the broader family to which it belongs suggests significant roles in protease regulation and potential implications in health and disease. Further research is needed to explicitly delineate these associations and their biological significance.