### ABCC1 Gene Overview

**Gene Symbol:** ABCC1  
**Location:** Chromosome 16 (16p13.11)  
**Protein Product:** Multidrug resistance-associated protein 1 (MRP1)  

### 1. Associated Genes
ABCC1 is known to interact or functionally associate with several other genes and proteins, including but not limited to:

- **ABCC2 (MRP2)**: Another member of the MRP subfamily that also plays a role in drug resistance.
- **ABCB1 (MDR1/P-glycoprotein)**: A crucial transporter involved in the transport of various drugs and toxins.
- **SLC family transporters (e.g., SLC22A4)**: These transporters may work in conjunction with ABCC1 in the transport of small organic molecules and drugs.
- **GST genes (Glutathione S-transferases)**: These genes are involved in detoxification processes and may work alongside ABCC1 in handling xenobiotics.
  
### 2. Aging or Age-Related Diseases
ABCC1 is implicated in the following age-related processes and diseases:

- **Cancer**: As ABCC1 is known to confer resistance to chemotherapeutic drugs, its activity could be linked to the increased incidence of drug resistance in older cancer patients.
- **Neurodegenerative Diseases**: Altered expression of ABCC1 may play a role in diseases like Alzheimer’s, as its transport function could influence the clearance of neurotoxic compounds.
- **Inflammatory Responses**: With aging often comes increased inflammation, and ABCC1's role in exporting leukotriene C4 indicates it may participate in modulating inflammatory responses that could be dysregulated in older individuals.

### 3. Drug Interactions
ABCC1 interacts with a variety of drugs across several therapeutic classes, including:

- **Chemotherapeutics**: Such as methotrexate and doxorubicin, where ABCC1 mediates efflux, leading to reduced efficacy.
- **Non-steroidal anti-inflammatory drugs (NSAIDs)**: It has been shown to transport certain NSAIDs affecting their pharmacokinetics.
- **Antiviral Drugs**: Some antiviral agents are substrates of ABCC1, impacting drug levels in cells.
- **Antibiotics**: Some members of this class may interact with ABCC1, influencing their resistance profiles.

### 4. Pathways and Biological Processes
ABCC1 is involved in multiple biological pathways and processes, including:

- **Drug Metabolism and Transport**: Participation in xenobiotic transport via the ABC superfamily, especially dealing with organic anions.
- **Cellular Responses to Stress**: Mediating the export of glutathione and its conjugates plays a significant role in cellular detoxification.
- **Regulation of Inflammatory Responses**: As mentioned, it exports leukotriene C4 and other mediators involved in inflammation.
- **cGAMP Export Pathway**: Inhibits the cGAS-STING pathway, impacting innate immune responses.
  
ABCC1 also has implications in the biosynthesis and transport of bioactive lipids, affecting numerous signaling pathways relevant to cell function and survival.

Overall, ABCC1 plays a crucial role in mediating drug resistance, detoxifying cellular environments, and influencing inflammatory processes, which have broader implications in pharmacology, aging, and disease mechanisms.