The SPICE1 gene, also known as "SPICE family member 1," encodes a protein that plays a critical role in cell division, specifically in processes related to mitotic spindle formation and centriole duplication. Here are more details about the gene, including its associations and related biological concepts:

### 1. Genes Associated with SPICE1
While the gene summaries you provided do not specify associated genes, SPICE1 is often discussed in the context of other genes involved in centrosome and spindle dynamics, such as:
- **CCNB1 (Cyclin B1)**: Essential for the regulation of the cell cycle at the G2/M transition.
- **PLK1 (Polo-like kinase 1)**: Plays a key role in coordinating cell cycle progression.
- **AURKA (Aurora kinase A)**: Important for spindle assembly and chromosome alignment.
- **TPX2 (Targeting Protein for Xenopus Kinesin-like Protein 2)**: Involved in the regulation of spindle assembly.

### 2. Aging and Age-related Diseases
Research indicates that centrosome dysfunction, including issues related to centriole duplication regulated by proteins like SPICE1, may contribute to age-related diseases, including:
- **Cancer**: Abnormalities in mitotic spindle function and chromosome segregation can lead to aneuploidy, a hallmark of many cancers.
- **Neurodegenerative Disorders**: Aging is associated with a decline in centrosome function, which can affect neuronal stability and may be linked to diseases like Alzheimer's.
- **Cardiovascular Diseases**: Centriolar dysfunction can affect cardiac myocyte division and regeneration, relevant in aging populations.

### 3. Drug Interactions
Currently, there is limited specific information about drugs directly targeting SPICE1. However, potential drug classes that may impact pathways involving SPICE1 include:
- **Antimitotic Agents**: Such as taxanes (e.g., paclitaxel) and vinca alkaloids (e.g., vincristine), which disrupt the mitotic spindle and can affect processes involving SPICE1.
- **Kinase Inhibitors**: Drugs targeting cell cycle signaling pathways, such as PLK1 inhibitors or Aurora kinase inhibitors, could indirectly impact the function of SPICE1 through modulation of related processes.

### 4. Pathways and Biological Processes
SPICE1 is involved in several biological processes and signaling pathways:
- **Mitotic Spindle Assembly Checkpoint**: Ensures proper chromosome segregation during cell division.
- **Centriole Duplication**: Critical for the formation of centrosomes and proper spindle function.
- **Cell Cycle Regulation**: Directly implicated in the regulation and transition of various phases of the cell cycle.
- **Chromosome Congression**: Essential for the alignment of chromosomes during metaphase.

### Summary
SPICE1 plays an important regulatory role in cell division, particularly in mitotic spindle assembly and centriole replication. Its dysregulation may have implications in cancer, neurodegeneration, and cardiovascular diseases associated with aging. While specific drugs targeting SPICE1 are not well-documented, its interactions with various cell cycle and mitotic inhibitors highlight its potential as a point of therapeutic interest. Ongoing research may uncover further associations and therapeutic opportunities related to SPICE1 in the context of aging-related pathophysiology.