The PPFIA2-AS1 gene, also known as PPFIA2 antisense RNA 1, is a long non-coding RNA (lncRNA) associated with the PPFIA2 gene, which encodes a member of the protein tyrosine phosphatase family. 

### 1. Related Genes
PPFIA2-AS1 is primarily associated with its sense gene, **PPFIA2 (Protein Phosphatase, Fe, PtdIns, and Actin-binding 2)**. Some related genes may include:

- **PTK2 (Protein Tyrosine Kinase 2)**: Involved in cell migration and survival.
- **RHOA (Ras Homolog Family Member A)**: Plays a role in cytoskeletal dynamics and cellular events regulated by the actin cytoskeleton. 
- **PTPRD (Protein Tyrosine Phosphatase Receptor Type D)**: Involved in signal transduction pathways.

**Note**: The biological networks involving lncRNAs often connect to multiple other genes, so more associations are frequently uncovered with further studies.

### 2. Aging and Age-Related Diseases
While specific literature directly associating PPFIA2-AS1 with aging or age-related diseases is limited, long non-coding RNAs have been implicated in several processes related to cellular regulation, including:

- **Cellular Senescence**: By influencing pathways that modulate cell cycle progression, lncRNAs may play a role in cellular aging.
- **Cancer**: Altered expression of lncRNAs has been linked with various cancers, some of which may correlate with aging, as cancer risk increases with age.
  
Research into PPFIA2-AS1's specific functions could elucidate its potential involvement in such processes.

### 3. Drug Interactions
As PPFIA2-AS1 is an lncRNA, it typically does not interact directly with drugs in the way that protein-coding genes might. However, alterations in its expression could indirectly influence the efficacy or metabolism of drugs targeting related pathways, especially those related to cancer or cellular signaling pathways. No specific drugs or drug classes have yet been detailed in current literature as directly interacting with PPFIA2-AS1.

### 4. Pathways and Biological Processes
PPFIA2 and its associated lncRNA, PPFIA2-AS1, are primarily involved in the following biological processes:

- **Cell Adhesion**: PPFIA2 is known to assist in the regulation of cell adhesion and migration, primarily through interactions with the cytoskeleton and extracellular matrix.
- **Signal Transduction**: PPFIA2 has roles in the modulation of signaling pathways that influence cellular responses.
- **Actin Cytoskeleton Organization**: The gene is also implicated in processes related to the cytoskeleton structure and organization.

Research continues to be performed to further delineate the detailed functional roles of PPFIA2-AS1 and its implications in various biological contexts, including but not limited to its potential relevance in disease mechanisms. 

### Summary
In conclusion, while PPFIA2-AS1 is primarily associated with the PPFIA2 gene and its regulatory functions, research is still underway to fully understand its roles, particularly in the context of aging and related pathologies. As lncRNA research advances, further insights may reveal significant interactions and pathways associated with PPFIA2-AS1.