### FBXO24 Gene Summary

**Gene Symbol:** FBXO24

**Function:** The FBXO24 gene encodes a member of the F-box protein family, which is crucial for targeted protein degradation through the ubiquitin-proteasome pathway. Specifically, FBXO24 serves as a substrate-recognition component of the SCF-type (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins in a phosphorylation-dependent manner. FBXO24 is categorized under the Fbxs class of F-box proteins, indicating its involvement in diverse protein-protein interactions and signaling pathways.

### 1. Associated Genes

While specific associated genes are not always explicitly listed in databases, FBXO24 may interact with numerous proteins in the context of the SCF complex and other cellular pathways. Some candidate genes and proteins that might interact with FBXO24 include:
- **SKP1**: Essential for the formation of the SCF E3 ligase complex, SKP1 interacts directly with F-box proteins like FBXO24.
- **CUL1**: A core component of the SCF complex that is integral to its function in ubiquitination.
- Potential substrates of FBXO24 are typically proteins involved in cell cycle regulation, signaling cascades, or transcriptional regulation, though specific interactions may require detailed proteomic analyses.

### 2. Aging or Age-related Diseases

There is emerging evidence that the dysregulation of ubiquitin-proteasome-mediated pathways, including those involving F-box proteins like FBXO24, may be implicated in aging processes and age-related diseases. While specific studies on FBXO24 are limited, general findings regarding F-box proteins suggest that:

- Alterations in ubiquitination processes can contribute to cellular senescence and compromised cellular function often observed in aging.
- Proteins regulated by FBXO24 may play roles in longevity pathways, cellular stress responses, and diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.

### 3. Drug Interactions

As of October 2023, there is limited direct data on specific drugs or drug classes that interact with the FBXO24 gene and its encoded protein. However, general classes of drugs that may affect ubiquitin-proteasome pathways or the SCF complexes could include:

- **Proteasome inhibitors**: Such as bortezomib, which indirectly leads to the accumulation of proteins that may normally be substrates for F-box proteins.
- **Kinase inhibitors**: Since FBXO24 is involved in phosphorylation-dependent ubiquitination, drugs that alter kinase activity might influence the activity of FBXO24-mediated pathways.

### 4. Pathways and Biological Processes

FBXO24 is implicated in several pathways and biological processes, including:

- **Ubiquitin-mediated proteolysis**: As part of the SCF E3 ubiquitin ligase complex, FBXO24 plays a central role in tagging proteins for degradation.
- **Cell cycle regulation**: FBXO24 may be involved in regulating proteins critical for cell cycle progression and checkpoint controls.
- **Signal transduction**: Involvement in pathways that respond to external signals is likely, as FBXO24's function is tied to phosphorylation status.
- **Regulation of protein stability**: By tagging specific proteins for degradation, FBXO24 impacts overall cellular protein turnover, which is critical for maintaining cellular homeostasis.

### Conclusion

The FBXO24 gene encodes a vital component of the ubiquitin-proteasome pathway, influencing a variety of cellular processes, potentially including those related to aging and age-related diseases. Ongoing research will be essential to decode its specific interactions and implications in health and disease.