### SNORD114-9 Gene Overview

**Gene Symbol**: SNORD114-9

**Description**: SNORD114-9 is a small nucleolar RNA (snoRNA) gene located in the nucleolus, primarily involved in the modification and processing of ribosomal RNA (rRNA). It belongs to the box C/D class of snoRNAs, which are crucial for guiding the methylation of rRNA.

### 1. Associated Genes

SNORD114-9 is part of the SNORD114 gene cluster, which contains multiple snoRNAs. Other genes that could be associated include:

- **SNORD114-1 to SNORD114-6**: These genes are within the same cluster and function similarly as snoRNAs.
- **RBM15**: It has been speculated that some snoRNAs have roles in RNA splicing, and RBM15 is involved in splicing mechanisms, possibly interacting indirectly.
  
While the association may not necessarily denote direct interactions, these genes share a common functional pathway in RNA metabolism and modification.

### 2. Aging and Age-Related Diseases

As of now, specific studies directly correlating SNORD114-9 with aging or age-related diseases are limited. However, snoRNAs, including SNORD114-9, have been implicated in broader biological processes such as ribosome biogenesis and cellular stress responses, which can influence aging. 

1. **Cellular Senescence**: snoRNAs are involved in the response to cellular stress, which can contribute to senescence and age-related decline in ribosome production.
2. **Altered Expression in Disease**: Some studies have observed that snoRNA expression can change in various cancers, which are often associated with aging.

No clear, direct association of SNORD114-9 with specific age-related diseases has been definitively elucidated at this time.

### 3. Drugs and Drug Classes Interacting with SNORD114-9

Currently, there are no specific drugs or drug classes recognized to have a definitive interaction with SNORD114-9. The study of snoRNAs in drug interactions is an emerging field, and as research continues, this landscape may evolve. 

### 4. Pathways and Biological Processes

SNORD114-9 is involved in several critical biological activities:

- **Ribosome Biogenesis**: One of the main functions of SNORD114-9 is in the modification of pre-rRNA, which is essential for ribosome assembly.
- **rRNA Methylation**: As a member of the box C/D snoRNAs, SNORD114-9 guides the methylation of specific rRNA residues, influencing ribosome function and protein synthesis.
- **Cellular Growth and Proliferation**: By participating in ribosome biogenesis and rRNA processing, SNORD114-9 plays a role in regulating cell growth and proliferation.

Further exploration in the context of its interactions in broader cellular processes may yield more detailed insights.

### Conclusion

SNORD114-9 is a small nucleolar RNA primarily involved in ribosomal RNA processing and modifications. While associations with aging and drug interactions remain limited or unclear, it plays vital roles in important biological processes that affect cellular function. Future research may help clarify its functions and associations further, especially in the context of disease and aging.