### ADAMTS17 Gene Overview

**Gene Symbol:** ADAMTS17  
**Location:** Chromosome 5  
**Gene Type:** Protein-coding gene

The ADAMTS17 gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, which is characterized by several protein domains, including:

- Propeptide region
- Metalloproteinase domain
- Disintegrin-like domain
- Thrombospondin type 1 (TS) motifs

The protein is involved in various biological processes and has implications in diseases, most notably genetics related to connective tissue disorders.

### Associated Genes
While specific co-expression data might not be provided in the original summaries, ADAMTS family members and other related genes involved in extracellular matrix remodeling and connective tissues may be associated with ADAMTS17. Candidate genes for additional conditions or functions include:

- **FBN1:** Mutations in this gene cause Marfan syndrome, which may share overlapping phenotypes with Weill-Marchesani-like syndrome.
- **COL11A1:** Mutations in collagen genes that might interact in ocular and skeletal systems.
- **LOXL1:** Associated with glaucoma, which overlaps with one of the features of Weill-Marchesani syndrome.

### Aging and Age-Related Diseases
While direct connections between ADAMTS17 and aging or age-related diseases may not be well-characterized:

- **Cataracts and Lens Opacities:** The phenotypic manifestations linked to ADAMTS17 mutations, such as lenticular myopia and ectopia lentis, suggest a potential association with age-related ocular conditions.
- **Glaucoma:** Since ectopia lentis and glaucoma are associated with Weill-Marchesani-like syndrome, research into the gene's impact on the ocular matrix during aging or in glaucomatous conditions could be valuable.

### Drug Interactions
There are currently no specific drugs directly targeting ADAMTS17. However, broader classes of drugs that affect extracellular matrix dynamics or metalloproteinases may indirectly influence its expression or activity:

- **Matrix Metalloproteinase Inhibitors:** These can inhibit similar functions but do not specifically target ADAMTS17.
- **Anticancer Drugs:** Given its role in promoting cell growth, certain drugs targeting cancer pathways may indirectly affect ADAMTS17 expression.

### Pathways and Biological Processes
ADAMTS17 is involved in several biological processes, including but not limited to:

- **Extracellular Matrix Organization:** The ADAMTS family is primarily known for their roles in remodeling the extracellular matrix.
- **Tissue Morphogenesis:** Participation in structural formation of tissues.
- **Cell Proliferation and Survival:** Specifically in the context of cancer, as it promotes breast cancer growth and survival.
- **Response to Wounding:** Implicated in tissue repair mechanisms.

Researching more detailed specific interactions of ADAMTS17 could further clarify its roles beyond these generalized pathways.