### TMEM204 Gene Overview

**Gene Symbol**: TMEM204  
**Protein Summary**: TMEM204 is a transmembrane protein believed to influence paracellular permeability and is thought to participate in cell-cell interactions via adherens junctions, which are critical for maintaining tissue integrity and homeostasis.

#### 1. Associated Genes
While specific associations were not detailed in the summaries provided, TMEM204 has been studied in relation to various other genes involved in cell adhesion and permeability. Some genes that may show associations or interactions include:
- **CDH1 (E-cadherin)**: A critical gene involved in adherens junctions.
- **CLDNs (Claudins)**: A family of proteins integral to tight junctions and paracellular permeability.
- **Z0NULIN**: Associated with the regulation of tight junctions and barrier functions.
- **VE-Cadherin (CDH5)**: Important for endothelial cell-cell adhesion.

This is not an exhaustive list; further research may reveal additional connections.

#### 2. Aging and Age-Related Diseases
While specific information directly linking TMEM204 to aging or age-related diseases may not be widely documented, genes involved in cell-cell interactions and junction integrity play significant roles in:
- **Tissue repair and regeneration**: Impairment in these processes is often observed with aging.
- **Inflammatory diseases**: Disruption of tight and adherens junctions has been implicated in age-related inflammatory conditions.
- **Cancer**: Alterations in cell adhesion are frequently associated with increased metastasis in aged populations.
Further investigation into literature regarding TMEM204 specifically in the context of aging and disease may help clarify its potential roles.

#### 3. Drug Interactions
Currently, specific drugs or drug classes directly interacting with TMEM204 are not well characterized. Research involving this gene in pharmacogenomics or personalized medicine may yield relevant findings. Studies could explore how modulation of TMEM204 affects drug efficacy or toxicity, particularly in the context of diseases influenced by cellular junction integrity.

#### 4. Pathways and Biological Processes
TMEM204 is involved in various biological processes, including:
- **Cell adhesion**: Plays a role in the formation and maintenance of adherens junctions, impacting tissue structure and function.
- **Paracellular transport**: Influences the permeability of epithelial tissues by regulating the gaps between cells, which is crucial for nutrient and waste exchange.
- **Wound healing and tissue remodeling**: Though more research is needed, its role in cell-cell interactions suggests involvement in processes critical for repair and regeneration.

#### Conclusion
TMEM204 serves as an important factor in cellular architecture and dynamics through its influence on paracellular permeability and cell-cell adhesion. While direct links to aging and specific drug interactions require further investigation, understanding its biological roles could provide insights into various physiological and pathological processes, especially in the context of age-related changes and diseases. Additional studies may unravel its broader implications in health and disease.