### HEPACAM2 Gene Overview

**Gene Symbol:** HEPACAM2  
**Location:** Chromosome 4 (4q26)  
**Function:** The HEPACAM2 gene encodes a protein that is part of the immunoglobulin superfamily and is crucial for proper mitosis, particularly during prometaphase, when chromosomes are aligned at the metaphase plate.

#### 1. Associated Genes
The HEPACAM2 gene is known to interact with several other proteins and genes, although not all interactions are extensively studied. Notably:
- **AKAP9 (A-Kinase Anchoring Protein 9):** Interacts with HEPACAM2 and is involved in anchoring protein kinase A to specific locations within the cell.
- **TNKS (Tankyrase):** The poly(ADP-ribosylation) of HEPACAM2 is mediated by TNKS, leading to its translocation to the centrosomes. 

While these interactions are critical, other genes related to centrosome function and mitosis may also be involved in the broader context of HEPACAM2 function but are not explicitly mentioned in typical summaries.

#### 2. Aging and Age-Related Diseases
Information regarding HEPACAM2's direct role in aging or age-related diseases is sparse. However, since centrosome maturation and mitotic integrity are essential for cellular health, dysregulation or loss of function in genes like HEPACAM2 could potentially contribute to:
- **Aging Cellular Phenotypes:** Accumulation of DNA damage, genomic instability, and abnormal cell division may relate to aging processes.
- **Cancer:** As highlighted in the provided summaries, deletions involving HEPACAM2 are associated with myeloid leukemia and myelodysplastic syndromes. These conditions often arise from age-related changes in the hematopoietic system.

#### 3. Drug Interactions
As of the latest data, specific drugs or drug classes that directly target or interact with the HEPACAM2 protein are not thoroughly documented. However, drugs that promote poly(ADP-ribosylation) processes, such as PARP inhibitors (e.g., Olaparib), might indirectly affect HEPACAM2 functioning since its activity is modulated through poly-ADP-ribosylation by TNKS.

#### 4. Pathways and Biological Processes
HEPACAM2 is involved in several key biological processes and pathways, including:
- **Cell Cycle Regulation:** Essential during the G2/M transition for maintaining genomic stability.
- **Mitosis:** Particularly significant during prometaphase for facilitating proper chromosome segregation.
- **Centrosome Maturation:** Plays a role in the formation of microtubules required for chromosome movement by stabilizing the gamma-tubulin ring complexes.
- **Signal Transduction:** May have indirect effects on signaling pathways that regulate mitotic processes, although specific pathways are less defined compared to direct roles.

Overall, HEPACAM2 appears to be a critical player in cellular division and its malfunction could have significant implications for cancerous developments and potentially the aging process. Further research is necessary to elucidate its full spectrum of interactions and functional significance in aging and disease.