### CLK3 Gene Overview

**Gene Symbol**: CLK3  
**Chromosomal Location**: 17q25.2  
**Gene Type**: Protein-coding  
**Protein Class**: Serine/threonine kinase; dual-specificity kinase  

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### 1. Associated Genes

While the summaries provided some well-known interactions (e.g., phosphorylation of SRSF1 and SRSF3), CLK3 is likely associated with other genes involved in splicing regulation and RNA processing, including:

- **SRSF1 & SRSF3**: These are both members of the serine/arginine-rich (SR) family and are involved in pre-mRNA splicing.
- **SRPK1 (Serine/Arginine Protein Kinase 1)**: Another kinase involved in the phosphorylation of SR proteins.
- **F3 (Tissue Factor)**: CLK3 is known to regulate the alternative splicing of this gene's pre-mRNA.
- **Ras and Rho family GTPases**: Involved in signaling pathways that may intersect with CLK3 functions.

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### 2. Aging and Age-Related Diseases

Research indicates that CLK3 may play a role in the regulation of gene expression changes associated with aging. Although explicit aging-related studies of CLK3 may be limited, dual-specificity kinases like CLK3 generally contribute to cellular signaling pathways that can affect:

- **Cellular Senescence**: Altered splicing activities and RNA processing can be crucial in aging cells.
- **Age-related Diseases**: Dysregulation of spliceosome components and SR proteins can potentially lead to diseases such as cancer, neurodegenerative diseases, and cardiovascular disorders in older populations.

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### 3. Drug Interactions

As of my last knowledge update in October 2023, CLK3 itself has not been directly linked to specific drugs; however, due to its role in cell signaling and RNA processing, it may be indirectly influenced by drugs targeting pathways associated with:

- **Antineoplastic agents**: Targeting cancer processes may affect CLK3 activity through its involvement in splicing of oncogenes.
- **Kinase inhibitors**: General inhibitors that affect various serine/threonine kinases could modulate CLK3's activity.

No specific drug classes were firmly established for direct CLK3 targeting.

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### 4. Pathways and Biological Processes

CLK3 is involved in multiple biological processes, including:

- **Alternative Splicing**: CLK3 plays a crucial role in the regulation of pre-mRNA splicing mechanisms.
- **Cell Cycle Regulation**: By modifying splicing factors, CLK3 may influence cell cycle progression.
- **Nuclear Transport**: Its activity on splicing factors affects their localization and function within the nucleus.
- **Signal Transduction**: As a kinase, CLK3 is involved in signaling pathways that regulate cellular responses to various stimuli.
  
**Key Pathways**:
- **Spliceosomal Complex Assembly**
- **Cellular Response to DNA Damage**
- **Regulation of Gene Expression**

In summary, CLK3 is an essential kinase that intersects with various cellular processes, particularly RNA splicing and gene expression, contributing to both normal cellular functions and potentially influencing age-related biological phenomena. Further studies will clarify its specific roles in health and disease.