### Overview of the PDZD11 Gene

**Gene Symbol:** PDZD11  
**Location:** Chromosome 3

**Function:** The PDZD11 gene encodes a protein that facilitates interactions between various cellular components, particularly in the basolateral plasma membrane and cytosol. It possesses a protein C-terminus binding activity and is crucial for the assembly of pore complexes. The protein is known to mediate the docking of ADAM10 to the zonula adherens by interacting with PLEKHA7, which is necessary for PLEKHA7's interaction with the ADAM10-binding protein TSPAN33.

### 1. Associated Genes
While the summaries provided mention interactions with ADAM10 and PLEKHA7, other genes associated with PDZD11 through protein interactions or related biological processes include:

- **TSPAN33:** This gene is specifically mentioned in the context of the interaction with PLEKHA7.
- **ADAM10:** A disintegrin and metalloproteinase involved in various cellular processes like cell adhesion and signaling.
- **PLEKHA7:** Phospholipid-binding protein involved in cell junctions.
  
Additionally, gene co-expression studies may reveal further associations with other cellular signaling pathways or structural proteins, but those require specific context (like tissue type or disease state).

### 2. Aging and Age-Related Diseases
While there is limited direct literature on PDZD11 specifically related to aging or age-related diseases, its role in cellular adhesion and signaling through interactions with ADAM10 has implications in various pathological conditions, including cancer progression and neurodegenerative diseases. Changes in cell junction integrity and signaling dynamics have been shown to contribute to such age-related deterioration, making PDZD11 a potential player in those contexts.

- **Neurodegenerative Diseases:** The interaction of PDZD11 with ADAM10 may influence amyloid precursor protein (APP) processing, which is significant in Alzheimer's disease.
- **Cancer:** Dysregulation of proteins involved in cell signaling and adhesion, including those linked to PDZD11, may influence tumor progression and metastasis.

### 3. Drug Interactions
There are currently no specific drugs or drug classes formally identified as directly interacting with PDZD11. However, drugs targeting the ADAM10 enzyme, which is involved in various signaling pathways and cellular interactions, may indirectly influence PDZD11-related mechanisms. Future research may identify alternative compounds that could modulate PDZD11 expression or function.

### 4. Pathways and Biological Processes
PDZD11 is involved in several biological processes and signaling pathways:

- **Pore Complex Assembly:** Integral to the structure and function of nuclear pore complexes, facilitating transport across the nuclear envelope.
- **Cell Adhesion:** Involved in maintaining the structure and function of cellular junctions, particularly in epithelial cells.
- **Signal Transduction:** Plays a role in the transmission of signals from outside the cell to the interior, which is crucial for various cellular responses such as growth and differentiation.
- **Intercellular Communication:** Facilitates communication between adjacent cells via adhesion molecules and integrins.

#### Summary
PDZD11 plays a multifaceted role in cellular integrity and signaling, with implications in health and disease, particularly in processes relating to cell adhesion, signaling pathways, and potentially in aging and degeneration. Further research may elucidate its full range of functions and therapeutic potentials.