### WDR75 Gene Overview

The **WDR75** gene encodes a protein that plays a critical role in ribosome biogenesis. The protein is particularly involved in the processing of pre-ribosomal RNA, which is crucial for the formation of ribosomes. It has RNA binding activity and positively regulates both rRNA processing and transcription by RNA polymerase I. This gene is located in the nucleolus and functions as a ribosome biogenesis factor associated with the small subunit (SSU) processome, which is essential for generating the small eukaryotic ribosomal subunit.

### Associated Genes
While the summaries you provided do not specify additional genes commonly associated with WDR75, it is often linked to other ribosome biogenesis factors and components in the ribosomal assembly pathway:
- **RPS15**: Ribosomal protein S15, which is part of the small ribosomal subunit.
- **RPL3**: Ribosomal protein L3, involved in the assembly and function of the ribosome.
- **RNA binding proteins**: Other general RNA chaperones involved in ribosome assembly and RNA processing.

### Aging and Age-Related Diseases
Though there is limited direct information linking WDR75 to aging or specific age-related diseases, disruptions in ribosome biogenesis have been implicated in a range of age-associated conditions:
- **Cancer**: Alterations in ribosome biogenesis, including those involving WDR75, can contribute to tumorigenesis, as rapidly growing tumors often have heightened demands for protein synthesis.
- **Neurodegenerative Diseases**: Impaired ribosome biogenesis has been associated with diseases like Alzheimer's disease, where protein synthesis is crucial for neuronal health.

### Drug Interactions
As of the latest data, specific drugs or drug classes that directly target or specifically interact with WDR75 are not well-documented. However, it is important to consider:
- **Drugs targeting ribosome biogenesis**: These may indirectly affect the function of WDR75 by altering the overall ribosome production necessary for cellular health. For example, antibiotics that inhibit bacterial ribosomes may share mechanisms that could theoretically impact similar processes in eukaryotic translation.

### Pathways and Biological Processes
WDR75 is involved in several key biological processes and pathways, including:
- **Ribosome biogenesis**: WDR75 is crucial for processing pre-rRNA during nucleolar assembly resulting in functional ribosomal components.
- **RNA processing**: Facilitating the cleavage and modification of nascent pre-rRNA.
- **Transcription regulation**: Specifically, it positively regulates transcription mediated by RNA polymerase I, ensuring proper production of rRNA.
- **Nucleolar organization**: As part of the small subunit processome, it is involved in the spatial and functional organization of nucleolar activities.

In summary, WDR75 is vital to the intricate processes of ribosome biogenesis and RNA processing, and while it is not directly associated with specific drugs or extensively studied in the context of aging, its role in ribosomal function suggests relevance to age-related cellular decline and disease processes. Further research in these areas could elucidate its potential as a therapeutic target in age-related diseases and conditions involving dysregulated ribosome biogenesis.