### RBM23 Gene Overview

**Gene Symbol:** RBM23  
**Chromosomal Location:** 13q14.11  
**Protein Length:** 481 amino acids  
**Molecular Weight:** Approximately 54 kDa  

#### 1. Associated Genes
RBM23 is associated with several other genes, particularly those involved in RNA processing, splicing mechanisms, and steroid hormone signaling. Notable associated genes include:

- **U2AF proteins (e.g., U2AF1, U2AF2)**: Essential components of the spliceosome, involved in pre-mRNA splicing.
- **STARD1, STAR, and STARD2**: Genes involved in steroidogenesis, highlighting a regulatory connection in steroid hormone signaling.

#### 2. Aging and Age-related Disease Associations
Research has suggested that RBM23 may play a role in cellular processes affected by aging, particularly in terms of alternative splicing regulation. Here are a few points regarding its potential connections to aging and age-related diseases:

- **Increased splicing regulation with age**: Alterations in splicing factors, including RBM23, may contribute to the dysregulation of gene expression patterns seen in aged tissues.
- **Cancer**: Variants and dysregulation of splicing factors like RBM23 have been implicated in various cancers, which are more prevalent in aged populations. Its role in regulating alternative splicing may impact tumorigenesis.

#### 3. Drug Interactions
While specific drugs directly interacting with RBM23 are not extensively documented, the gene's role in steroid hormone receptor-mediated transcription implies that it may be indirectly influenced by steroid hormones (e.g., estrogens, androgens) and anti-hormonal therapies. Some drug classes of interest include:

- **Selective Estrogen Receptor Modulators (SERMs)**: May affect transcriptional activity.
- **Corticosteroids**: Could influence signaling through steroid receptors that RBM23 interacts with.

Further clinical investigations are required to determine specific drug-gene interactions directly.

#### 4. Pathways and Biological Processes
RBM23 is involved in several crucial biological pathways and processes:

- **RNA Processing**: Primarily functions as a pre-mRNA splicing factor, playing a central role in the maturation of mRNA.
- **Transcription Regulation**: Acts as a transcription coactivator, significantly influencing gene expression, particularly in response to steroid hormone signaling.
- **Steroid Hormone Response Pathways**: Assists in mediating the cellular response to steroid hormones, implicating it in processes like metabolism, growth, and development.
- **Regulation of Alternative Splicing**: Important for modulating splice variant production in response to various signals, which can alter protein function and diversity.

Overall, RBM23 is a multifaceted gene with crucial implications in gene expression regulation, particularly within the context of steroid hormone signaling and alternative RNA splicing. Further studies may elucidate its roles in aging and disease mechanisms.