### CSNK2A3 Gene Overview

**Gene Symbol**: CSNK2A3  
**Protein**: Casein kinase II, alpha 3 (CK2A3)  
**Location**: Human chromosome 20

### Summary of the Gene
CSNK2A3 encodes a protein that is part of the casein kinase II (CK2) family, specifically the alpha subunit, which is a serine/threonine protein kinase implicated in a range of cellular processes, including cell proliferation and survival. The kinase phosphorylates numerous substrates and is crucial in regulating various signaling pathways. Mutations in CSNK2A3 have been connected to a higher risk of lung cancer, although there is ongoing debate regarding its classification as a protein-coding gene versus a processed pseudogene.

### 1. Associated Genes
CSNK2A3 has connections to several other genes, especially those involved in kinase pathways and cancer. Notable associations may include:

- **CSNK2A1 and CSNK2A2**: Other catalytic and regulatory subunits of the CK2 complex.
- **TP53**: Tumor protein p53, a crucial tumor suppressor that may interact with CK2 signaling pathways.
- **PML**: Promyelocytic leukemia protein, which is known to be downregulated by CSNK2A3, influencing tumorigenesis.

### 2. Known Details Related to Aging or Age-Related Diseases
While direct evidence linking CSNK2A3 to aging or specific age-related diseases is limited, the role of CK2 in cellular proliferation and survival suggests potential implications in age-related pathologies, such as:

- **Cancer**: As a possible oncogene, dysregulation of CSNK2A3 may contribute to age-related increase in cancer susceptibility.
- **Neurodegenerative diseases**: Some studies have suggested that CK2 activity may play a role in neuroprotection, and its dysregulation could be associated with conditions like Alzheimer’s disease.

### 3. Drug or Drug Classes Interaction
Though specific drugs targeting CSNK2A3 might not be widely established, the following classes and compounds are known to interact with the CK2 pathway or exhibit effects on CK2 activity:

- **CK2 Inhibitors**: Such as **Sodium Stibogluconate**, **4,5,6,7-tetrabromo-2-azoquinoline** (TBB), and **CX-4945**; these are studied for their potential to inhibit CK2 activity broadly.
- **Cancer Therapeutics**: Various chemotherapeutic drugs that target signaling pathways often impacted by CK2 may also indirectly interact with CSNK2A3 regulation.

### 4. Pathways and Biological Processes
CSNK2A3 is involved in numerous biological pathways, including:

- **Cell Cycle Regulation**: Influencing progression through different phases of the cell cycle.
- **Phosphorylation signaling**: Involved in post-translational modifications that regulate numerous protein functions.
- **Apoptosis and Survival**: Plays a role in cellular survival signaling potentially impacting tumorigenesis.
- **Cellular Development and Differentiation**: Contributes to processes that determine cell fate and functional specialization.
  
### Conclusion
CSNK2A3 is an essential gene with a significant role in kinase signaling involved in tumorigenesis, potentially influencing cancer development such as lung cancer. Its connections to aging, its role in various pathways, and pharmacological interactions underscore its biological importance and potential therapeutic relevance. Further research is necessary to clarify its status as a protein-coding gene and the implications of its functions in health and disease.