**Gene Summary: PSRC1**

**Gene Symbol**: PSRC1  
**Location**: Chromosome 1 (1p32.2)

### 1. Associated Genes:
While PSRC1 is primarily studied in the context of its own functions in mitosis, it is also associated with various other genes, particularly those involved in the mitotic phase and tumor suppression. Some notable associated genes include:
- **TP53 (Tumor Protein p53)**: As PSRC1 is regulated by p53, it plays a significant role in cell cycle control and apoptosis.
- **KIF2A (Kinesin Family Member 2A)**: This gene, encoding a kinesin motor protein, is recruited by PSRC1 and is critical for microtubule depolymerization.
- **ANKRD53**: Another protein that interacts with PSRC1 and is involved in the regulation of the mitotic spindle.
- **AURKB (Aurora Kinase B)**: Although not directly regulated by PSRC1, it plays a crucial role in mitotic progression and may have interactions that affect PSRC1 activity.

### 2. Aging and Age-Related Diseases:
Research indicates that dysregulation of processes associated with PSRC1 could contribute to age-related cellular dysfunctions. Although specific associations with aging are less distinct, aberrations in mitotic processes (where PSRC1 plays a critical role) can contribute to:
- **Cancer**: As PSRC1 is associated with p53, which is frequently mutated in cancer, improper regulation of mitosis can lead to tumorigenesis.
- **Neurodegenerative Diseases**: Alterations in cell division and microtubule dynamics may play a role in neurodegenerative conditions, where misfolding and aggregation of proteins are common.
- **Tissue Regeneration**: The role of PSRC1 in mitosis may influence tissue repair mechanisms, which are generally less efficient with aging.

### 3. Drug Interactions:
Currently, specific drugs that directly target PSRC1 have not been widely documented. However, drugs that modulate microtubule dynamics in cancer therapy, such as:
- **Taxanes (e.g., Paclitaxel)**: These drugs stabilize microtubules and may indirectly influence the activity of associated proteins like PSRC1.
- **Vinca Alkaloids (e.g., Vincristine)**: These agents disrupt microtubule dynamics and may also affect processes regulated by PSRC1.

Future studies may identify more targeted agents affecting the pathways PSRC1 is involved in.

### 4. Pathways and Biological Processes:
PSRC1 is involved in several key biological pathways, including:
- **Mitosis**: Critical in chromosome alignment and segregation, ensuring accurate cell division.
- **Cell Cycle Regulation**: As it interacts with p53, it plays a role in the overall regulation of the cell cycle, influencing cell growth and apoptosis.
- **Microtubule Dynamics**: Enhances the turnover of microtubules on the metaphase spindle and regulates forces at the kinetochores, facilitating proper chromosome movement.
- **Cancer Pathway**: Given its relationship with p53 and roles in cell cycle regulation, it plays a part in cancer-related signaling pathways.

In summary, PSRC1 is a multifunctional protein with significant implications in cell cycle control, particularly during mitosis, and has associations with cancer signaling pathways and potential effects on aging-related cellular processes.