### VPS35P1 Gene Overview

**Gene Symbol:** VPS35P1  
**Entrez Gene ID:** 23337  
**UniProt ID:** Q8N7N4

The VPS35P1 gene is part of the VPS35 protein family and is a paralog of the VPS35 gene, which is involved in endosomal protein sorting and recycling. The VPS35 protein plays a crucial role in the retromer complex, which is essential for retrieving proteins from endosomes back to the trans-Golgi network or to the cell membrane.

### 1. Associated Genes
Aside from the known associations with its paralogs, VPS35 and other components of the retromer complex, here are some genes functionally or physically associated with VPS35P1:

- **VPS26A**: A component of the retromer complex, involved in cargo recognition and recruitment of the retromer complex to membranes.
- **VPS29**: Another retromer component that stabilizes the retromer complex.
- **RAB7A**: Involved in the transport of vesicles on microtubules towards lysosomes or endosomes, where VPS35P1 may play a role in cargo sorting.

### 2. Aging and Age-Related Diseases
The retromer complex has been implicated in aging and neurodegenerative diseases. Abnormalities in VPS35 gene function and retromer-mediated trafficking are associated with the pathogenesis of:

- **Neurodegenerative diseases**: Such as Alzheimer's disease, where the mismanagement of proteins important for neuronal maintenance leads to cellular dysfunction.
- **Parkinson's disease**: Mutations in VPS35 have been directly linked to familial forms of the disease.

While specific studies on VPS35P1 in the context of aging are limited, its role as a functional paralog to VPS35, known for its implications in these diseases, suggests potential involvement in age-related cellular dysregulation and neurodegeneration.

### 3. Drug Interactions
As of now, there are no specific drugs or drug classes that directly target VPS35P1. However, because of its role in cellular pathways that may affect age-related diseases, it is worth noting that some drugs targeting the retromer complex or involved in neuroprotection could indirectly affect VPS35P1 functions.

### 4. Pathways and Biological Processes
VPS35P1 is involved in various biological processes:

- **Protein recycling**: Essential in the retrieval of proteins from endosomes, it contributes to maintaining cellular protein homeostasis.
- **Endosomal sorting**: Plays a role in the transport of proteins to lysosomes or back to the cell surface.
- **Negative regulation of protein aggregation**: In the context of neurodegenerative diseases, improper sorting can result in the aggregation of misfolded proteins, thus affecting neuronal health.
- **Cellular response to stress**: It might indirectly participate in pathways that deal with cellular stress responses owing to its involvement in protein sorting and trafficking.

### Conclusion
VPS35P1 is an important gene that, while lesser-known, plays a significant role in cellular trafficking and potentially in age-related diseases through its involvement in the retromer complex. Further research into this gene could elucidate its role in relevant biological processes and its implications in aging and disease mechanisms.