### NR4A3 Gene Summary

**Gene Symbol:** NR4A3  
**Chromosome Location:** 9q22.2 (Human)

#### General Overview
The NR4A3 gene encodes a protein that is a member of the steroid-thyroid hormone-retinoid receptor superfamily and functions primarily as a transcriptional activator. The protein modulates gene expression by binding to specific regulatory elements in gene promoters. NR4A3 is involved in diverse biological processes, including cell proliferation, survival, differentiation, metabolism, inflammation, and development.

### 1. Related Genes
Apart from the genes mentioned in the NCBI and UniProt summaries, several other genes interact with or are associated with NR4A3:

- **CCND1:** Cyclin D1 - involved in cell cycle regulation.
- **RUNX1:** Runt-related transcription factor 1 - regulates blood cell development.
- **SLC2A4 (GLUT4):** Glucose transporter involved in glucose uptake by cells.
- **PARP1:** Poly (ADP-ribose) polymerase 1 - involved in DNA repair and programmed cell death.

### 2. Aging and Age-Related Diseases
NR4A3 may be implicated in aging and age-related diseases through its regulatory roles in cellular growth, differentiation, and metabolism. Although specific aging-related studies focused directly on NR4A3 are relatively sparse, some points of interest include:

- **Cellular Senescence:** Transcription factors including NR4A3 may affect senescence pathways influencing lifespan.
- **Alzheimer’s Disease:** Investigations suggest dysregulation of nuclear receptors, including NR4A3, can affect neuroinflammation and neuronal health, potentially linking it to Alzheimer’s disease and other neurodegenerative disorders.
- **Metabolic Disorders:** Given its role in regulating glucose transport (SLC2A4) and energy balance, NR4A3 may also be involved in age-related metabolic disorders such as type 2 diabetes.

### 3. Drug Interactions
The NR4A3 gene has been associated with responses to certain drugs and drug classes, which may interact through its modulation of gene expression:

- **Glucocorticoids:** NR4A3 interacts with glucocorticoid receptors and may modulate their action in tissues that respond to glucocorticoids.
- **Anti-inflammatory Drugs:** As NR4A3 is involved in inflammation, drugs targeting inflammatory pathways may also indirectly affect its activity.
- **Neuroprotective Agents:** Certain compounds known for their neuroprotective properties may influence NR4A3 expression or function, enhancing neuronal survival during stress conditions.

### 4. Biological Processes and Pathways
NR4A3 is involved in a wide array of biological processes and pathways, including but not limited to:

- **Regulation of Gene Expression:** Through binding to NBRE and NurRE, impacts the transcription of multiple target genes.
- **Cell Cycle Regulation:** Modulates the expression of cyclins such as CCND1 and CCND2, influencing cell cycle entry and progression.
- **Inflammation:** Mediates pro-inflammatory cytokine responses and factors such as VCAM1 and ICAM1 in response to inflammatory stimuli.
- **Metabolism:** Involved in glucose transportation, feedback mechanisms with neuropeptides related to appetite regulation, and energy homeostasis.
- **Development:** Plays roles during embryonic development, particularly in the formation of the mesoderm and growth of specific tissues like the inner ear.

### Key Takeaways
The NR4A3 gene has a multifaceted role in cellular function, with implications in health and disease, particularly in cellular proliferation, metabolism, and inflammation. Understanding its pathways and interactions can provide insights into its role in normal physiology and in the etiology of age-related diseases, potentially guiding therapeutic strategies targeting NR4A3-associated conditions.