### CDC5L Gene Overview

**Gene Symbol**: CDC5L  
**Location**: Chromosome 2 (2q37.3)  
**Protein Product**: CDC5L (Cell Division Cycle 5-Like protein)

CDC5L is an essential gene involved primarily in cell cycle regulation and pre-mRNA splicing. This gene is an ortholog of the cdc5 gene in *Schizosaccharomyces pombe*, a model organism, that plays a critical role in regulating the G2/M transition in the cell cycle. The gene product functions as a positive regulator of this transition and is integral to the assembly and function of the spliceosome.

### Associated Genes

While the summaries provided do not include specific associated genes, CDC5L is known to interact with various proteins and components involved in splicing and cell cycle control. Some of these include:

- **PRP19** (Pre-mRNA Processing Factor 19)
- **CDC5** (Cell Division Cycle 5)
- **SF3B** (Spliceosome-associated factor 3B)
- **SNRNP** (Small nuclear Ribonucleoproteins)

Additionally, CDC5L may interact with other spliceosome components, DNA repair proteins, and cell cycle regulators, although specific associations or direct interactions may not be extensively documented in the provided summaries.

### Aging and Age-Related Diseases

Current knowledge suggests that alterations in CDC5L function may contribute to cellular senescence, a hallmark of aging processes. Aberrant splicing and cell cycle dysregulation linked to CDC5L could lead to age-related diseases, particularly cancer. Since proper splicing is vital for maintaining the integrity of protein production and function, mutations or dysregulation of CDC5L may influence tumorigenesis and the aging process.

Studies also indicate potential roles of CDC5L in DNA damage responses, which are intertwined with aging and longevity. However, specific direct correlations with age-related diseases remain a developing area of research.

### Known Drug or Drug Classes

While specific drugs targeting CDC5L directly are not widely reported, due to CDC5L's involvement in critical cellular pathways, its dysregulation may indirectly influence responses to various classes of drugs, particularly:

- **Anticancer agents** (targeting proliferative cell cycle machinery)
- **Splicing modulators** (targeting spliceosomal activities)

Drug interactions can vary widely, and ongoing research may uncover potent compounds that selectively affect CDC5L-related pathways.

### Pathways and Biological Processes

CDC5L is involved in several key biological processes and pathways, including:

1. **Cell Cycle Regulation**: Direct involvement in the progression from G2 to M phase.
2. **Pre-mRNA Splicing**: As a core component of both the major and minor spliceosomes, CDC5L participates in the splicing of U2-type and U12-type introns.
3. **DNA Damage Response (DDR)**: The PRP19-CDC5L complex may play a role in the cellular response to DNA damage and repair mechanisms.
4. **Transcriptional Regulation**: Potential activity as a transcription activator suggests involvement in regulating gene expression linked to cell fate and proliferation.

These pathways emphasize CDC5L’s pivotal role not just in cell cycle control but also in maintaining overall cellular homeostasis and integrity.