### DEFB110 Gene Overview

**Gene Symbol:** DEFB110  
**Description:** The DEFB110 gene encodes a member of the beta-defensin family, which is characterized by their antimicrobial and cytotoxic properties. It is primarily expressed in neutrophils and contributes to the innate immune response by providing a rapid defense against microbial infection.

### Other Genes Associated with DEFB110

While the NCBI and UniProt summaries do not specify additional genetic associations, the DEFB110 gene is known to be part of a cluster that includes various other beta-defensin genes such as:

- **DEFB1 (Defensin Beta 1)**: Also contributes to antimicrobial activity.
- **DEFB4 (Defensin Beta 4)**: Involved in combating microbial infections.
- **DEFB2 (Defensin Beta 2)**: Plays a role in immune response.

These genes are often co-expressed and regulated in response to infections and inflammation.

### Known Details Related to Aging or Age-Related Diseases

Research has shown that the expression of defensins, including DEFB110, may change with age and influence susceptibility to infections. 

1. **Immunity and Aging:** The ability of the innate immune system to respond declines with age. Reduced expression of antimicrobial peptides, including defensins, in older adults has been linked to increased susceptibility to infections and slower healing rates.
  
2. **Age-Related Diseases:** Altered defensin expression has been implicated in conditions such as chronic obstructive pulmonary disease (COPD), cardiovascular diseases, and even some cancers. Defensins may play a protective role in preventing microbial infections that can complicate aging-related health issues.

### Drug or Drug Classes Interacting with DEFB110

As of my training cut-off in October 2023, there are no specific drugs directly targeting DEFB110. However, since it is part of the innate immune response, modulating the immune system through immunomodulators or anti-inflammatory drugs may indirectly affect the expression or activity of defensins. 

- **Immune Modiﬁers:** Drugs such as corticosteroids or other immunosuppressive agents can influence the expression of defensins, including DEFB110, thereby affecting immune responses.
- **Antibiotics:** While antibiotics target bacterial infections directly, they do not interact with DEFB110 directly but may influence its regulation during infections.

### Pathways and Biological Processes Involved

1. **Innate Immune Response:** DEFB110 plays a critical role in the body's first line of defense against pathogens through its antibacterial activity.
   
2. **Defensin Production Pathway:** It is part of a broader signaling network that activates the immune response upon microbial intrusion.

3. **Cytokine Signaling:** The expression of DEFB110 can be influenced by cytokines, particularly in inflammatory responses, supporting its role in linking innate and adaptive immune mechanisms.

4. **Antimicrobial Peptide Activity:** DEFB110 is involved in various biological processes related to the synthesis and secretion of antimicrobial peptides that target a wide range of pathogens, from bacteria to fungi.

In summary, the DEFB110 gene is integral to the innate immune defense through its production of antimicrobial peptides, with implications in disease processes related to aging and immune response.