### CD164 Gene Overview

**Gene Symbol:** CD164  
**Chromosomal Location:** 6q21  
**Function:** The CD164 gene encodes a transmembrane sialomucin and cell adhesion molecule that is pivotal in regulating hematopoiesis and modulating progenitor cell behavior.

### Associated Genes

In addition to the interactions mentioned in the summaries, CD164 is associated with several other genes and pathways:

1. **CD34** - Known as a hematopoietic progenitor marker, CD164 interacts with CD34 to influence cell adhesion and migration.
2. **CXCR4 (C-X-C chemokine receptor type 4)** - CD164 interacts with CXCR4, which mediates the migratory effects of CD164 in hematopoietic stem cell niches.
3. **CXCL12 (SDF-1)** - The ligand for CXCR4, critical for cell signaling in relation to migration associated with CD164 functions.
4. **CD38** - Involved in modulating the proliferation of hematopoietic progenitor cells together with CD164.
5. **MYOD** - An important gene in myogenesis, which may have functional interactions with CD164 in terms of skeletal muscle development.

### Aging and Age-Related Diseases

While specific studies related to aging in connection with CD164 are limited, some observations include:

1. **Hematopoietic Aging:** Elevated levels of CD164 have been reported in aged hematopoietic stem/progenitor cells, which may influence the aging process and alter hematopoiesis.
2. **Age-Related Hearing Impairment:** Mutations in CD164 have been associated with impaired hearing, a condition that is common in aging populations.
3. **Sezary Syndrome and Cancer:** As aging is a risk factor for various cancers, including Sezary syndrome, the upregulation of CD164 in such pathological contexts may link it to age-related changes in immune function or hematologic integrity.

### Drug Interactions

Currently, specific drugs or drug classes that interact directly with CD164 remain underexplored. However, understanding CD164's role in pathways involved in cancer metastasis might suggest relevance to therapies targeting:

- **Antineoplastic agents** - Given its associations with cancer metastasis, especially in prostate cancer, there could be implications for cancer therapies.
- **Immunomodulators** - As CD164 is involved in cell adhesion and migration of immune cells, drugs that aim to modulate immune responses may also impact CD164 activity.

### Pathways and Biological Processes

**Biological Processes Involved:**

- **Hematopoiesis**: CD164 plays an important role in the regulation of hematopoietic progenitor cell proliferation, adhesion, and migration.
- **Myogenesis**: Influences muscle development by enhancing myoblast migration and fusion into myotubes.
- **Cell Adhesion**: Acts as a sialomucin, promoting adhesion of hematopoietic stem cells to niche environments.
- **CXCL12/CXCR4 Axis Regulation**: Modulates stem cell mobilization and migration in response to chemokine signaling.

**Key Pathways:**

- **Hematopoietic Stem Cell Niche Pathway**: CD164 interaction with the stroma and other niche factors.
- **Myogenesis Pathway**: CD164's involvement in muscle precursor cell motility and fusion.
- **CXCR4 Signaling Pathway**: Mediating cellular migration and homing of stem cells in response to CXCL12.

### Summary

The CD164 gene is integral to hematopoietic processes, muscle development, and possibly influences aging and disease pathology. Its interactions with other key molecules like CD34 and CXCR4 highlight its versatility in cell physiology. The prospect of targeting CD164 in treatments pertaining to cancer and age-related conditions remains an area for future research.