### SNORD115-27 Gene Overview

**Gene Symbol:** SNORD115-27  
**Type:** Small nucleolar RNA (snoRNA) gene, part of the SNORD115 gene cluster. It is classified under C/D box snoRNAs, which are involved in guiding the modification of ribosomal RNA (rRNA) and other RNA molecules through methylation and pseudouridylation.

### Associated Genes

While specific associations with other genes are less frequently reported, small nucleolar RNAs like SNORD115-27 often interact indirectly with the following:

1. **Ribosomal protein genes:** Genes encoding ribosomal proteins may be indirectly related, as SNORD115-27 is involved in rRNA modification.
2. **Methyltransferase genes:** These genes might be involved in the processes of RNA modification that SNORD115-27 influences.

### Known Details Related to Aging or Age-Related Diseases

1. **Cognitive Function:** Some studies have suggested a link between the SNORD115 gene cluster and neurodevelopmental disorders, such as Prader–Willi syndrome, which may have implications in age-related cognitive decline.
2. **Cancer:** Dysregulation of snoRNAs, including SNORD115-27, has been observed in several cancer types. Altered expression of these genes may contribute to cancer progression, which can be exacerbated with age.
3. **Neurodegenerative Diseases:** There's ongoing research into the role of snoRNAs, including SNORD115-27, in conditions like Alzheimer’s disease, where dysregulation of synthesis and modification of rRNAs might be relevant.

### Drug or Drug Classes That Interact with this Gene

Currently, there are no specific drugs or drug classes directly known to interact with SNORD115-27. However, it is advisable to consider:

- **Antisense Oligonucleotides:** These are being explored for potential targeting of snoRNAs to modulate their expression, especially in cancer therapeutic strategies.
- **General RNA Modifying Agents:** Some experimental compounds that affect RNA metabolism may indirectly influence the function or expression of this snoRNA and its associated pathways.

### Pathways and Biological Processes Involved

1. **rRNA Methylation:** As a C/D box snoRNA, SNORD115-27 plays a crucial role in guiding the methylation of specific rRNA positions, essential for ribosome biogenesis and function.
2. **Gene Silencing:** SnoRNAs can also be involved in the regulation of gene expression post-transcriptionally.
3. **Splicing and RNA Processing Pathways:** They may have roles in pre-mRNA splicing and processing, contributing to gene expression regulation across various cellular contexts.

### Conclusion

SNORD115-27 is a small nucleolar RNA that serves vital functions in RNA modification and potentially influences several biological processes tied to ribosome function. While its direct associations with aging, diseases, and drugs are limited, the implications of its activity in broader biological and pathological contexts warrant further research to elucidate its significance fully.