### NUP155 Gene Overview

**Gene Symbol:** NUP155  
**Location:** Human chromosome 6p21.3  
**Function:** NUP155 is a member of the nucleoporins, which are integral components of the nuclear pore complex (NPC). It plays a crucial role in the assembly and function of the NPC, facilitating the translocation of macromolecules between the nucleus and cytoplasm. It is also involved in the fusion of nuclear envelope (NE) vesicles and the formation of the double membrane of the NE. Additionally, evidence suggests it may have implications in cardiac physiology, possibly linked to the pathogenesis of atrial fibrillation.

### 1. Associated Genes
While specific genes directly associated with NUP155 beyond its role in nucleocytoplasmic transport may not be extensively studied, it interacts with other nucleoporins and components of the nuclear pore complex. Notable associated genes and pathways may include:

- **NUP160**: Another nucleoporin part of the nuclear pore complex.
- **NUP37, NUP43, NUP50**: These nucleoporins also participate in nuclear transport processes.

### 2. Connection to Aging and Age-related Diseases
Current studies specifically linking NUP155 to aging or age-related diseases are limited. However, mutations or dysfunctions of nucleoporins, in general, have been implicated in:

- **Aging:** Disruptions in nucleocytoplasmic transport can affect cellular aging processes.
- **Neurodegenerative diseases**: Nuclear pore dysregulation has been implicated in disorders like ALS (amyotrophic lateral sclerosis) and other neurodegenerative conditions.
- **Cardiac diseases:** The association of NUP155 with atrial fibrillation also highlights its potential role in age-related cardiovascular changes.

### 3. Drug Interactions
As of October 2023, specific drugs explicitly targeting or interacting with NUP155 are not well-documented. However, drugs that influence nucleocytoplasmic transport, such as:

- **Importin inhibitors** and other nuclear transport modulators, which could theoretically interact with NUP155 indirectly.

Research is ongoing to explore drugs that may modulate the activity of nucleoporins within the nuclear pore complex.

### 4. Pathways and Biological Processes
NUP155 is involved in several key biological processes and pathways:

- **Nuclear pore complex assembly**: As an essential component, it is vital for the structural integrity and functionality of the NPC.
- **Nucleocytoplasmic transport**: Facilitates the movement of proteins, RNA, and other molecules between the nucleus and cytoplasm.
- **Nuclear envelope biogenesis**: Involved in the formation and organization of the nuclear envelope during the cell cycle.
- **Cardiac function**: Potential role in cardiac cellular processes, hinting at involvement in cardiac rhythm regulation.

Overall, NUP155 plays a critical role in cellular transport mechanisms and potentially contributes to cardiac health and age-related cellular processes. Further studies are needed to clarify its implications in specific pathologies and treatments.