### WTAP Gene Overview

**Gene Symbol:** WTAP  
**Location:** Chromosome 3p21.1

The WTAP gene (Wilms Tumor 1 Associated Protein) encodes a nuclear protein that is critical for various cellular functions, primarily related to RNA processing and cell-cycle regulation. It associates with the Wilms tumor 1 (WT1) protein and is involved in the N6-methyladenosine (m6A) methylation of RNA, which is essential for mRNA stability and splicing.

### Additional Associations

1. **Associated Genes:**
   - **METTL3:** Component of the m6A methylation complex, which interacts with WTAP.
   - **METTL14:** Another component of the m6A methylation complex.
   - **CCNA2 (Cyclin A2):** The regulation of its mRNA stability is impacted by WTAP.
   - **WT1:** The main tumor suppressor with which WTAP has strong associative interactions.

2. **Age-Related Details:**
   - **Aging and Disease:** While definitive age-related diseases directly attributed to WTAP have not been extensively characterized, its involvement in cell-cycle regulation suggests a potential role in age-related cellular senescence and cancer. Dysregulation of m6A modifications has been implicated in cancer and may share pathways with age-related malignancies due to its influence on RNA metabolism and gene expression.

3. **Drug Interactions:**
   - WTAP itself may not have direct drug interactions documented, but because it plays a critical role in the regulation of genes like CCNA2, which are important in cancer biology, drugs targeting cell cycle regulators, such as CDK inhibitors or mRNA splicing modulators, may indirectly affect WTAP-related pathways.
   - **Examples of Drug Classes:**
     - **CDK Inhibitors:** These affect the pathways related to cell-cycle regulation.
     - **RNA Splicing Modulators:** Such as those under investigation for cancer therapy.

4. **Pathways and Biological Processes:**
   - **RNA Metabolism:** WTAP is a major player in pre-mRNA splicing and m6A methylation, influencing gene expression and RNA stability.
   - **Cell Cycle Regulation:** Post-transcriptional regulation of genes involved in the G2/M phase transition, notably enhancing the stability of CCNA2 mRNA.
   - **Development:** Altered expression of WTAP has been implicated in Wilms tumor and potentially other developmental disorders.
   - **Tumorigenesis:** Given the interaction with WT1, its role in tumorigenesis and response to treatment in various cancers is of significant interest.

### Conclusion

The WTAP gene is vital not only in basic cellular processes like RNA splicing and cell-cycle regulation but also in the pathophysiology of diseases such as cancer. Its interactions and regulatory roles underline the importance of understanding such genes for potential therapeutic developments and understanding aging-related pathologies. Further research may elucidate more comprehensive roles in age-related diseases, drug interactions, and other associated genes.