### PPP4R3B Gene Overview

**Gene Symbol**: PPP4R3B  
**Location**: The PPP4R3B gene encodes a regulatory subunit for serine/threonine protein phosphatase 4 (PP4). It is primarily involved in the regulation of cellular processes through protein dephosphorylation and is implicated in gluconeogenesis. 

### 1. Associated Genes
The PPP4R3B gene may have functional interactions with several other genes involved in similar pathways, particularly those related to phosphatase activity and cellular signaling. Notable associations include:

- **PPP4C**: The catalytic subunit of the PP4 complex, which works with PPP4R3B to regulate various cellular functions.
- **CAPZB**: Associated with actin dynamics and may interact with PPP4R3B in cellular signaling pathways.

### 2. Aging and Age-Related Diseases
While specific studies directly tying PPP4R3B to aging or age-related diseases may be limited, its role in protein dephosphorylation and regulation of gluconeogenesis could have implications in metabolic disorders or neurodegenerative diseases, which are often linked to aging. Dysregulation in phosphatase activity can contribute to aging-related cellular dysfunction, oxidative stress response, and other processes that are significant in the context of aging.

### 3. Drug Interactions
As of my last update in October 2023, there are no specific drugs or drug classes widely recognized for directly targeting PPP4R3B. However, since it is a regulatory subunit of a phosphatase complex (PP4), modulators of phosphatase activity or general inhibitors of protein dephosphorylation pathways (like certain kinase inhibitors) may indirectly influence the activity of PPP4R3B.

### 4. Pathways and Biological Processes
PPP4R3B is involved in various biological processes and signaling pathways, including but not limited to:

- **Gluconeogenesis**: The process of synthesizing glucose from non-carbohydrate precursors is influenced by PPP4R3B via its regulatory role.
- **Regulation of Protein Phosphorylation**: Engaged in pathways involving serine/threonine protein dephosphorylation, crucial for various signaling cascades.
- **Cell Cycle Regulation**: It potentially contributes to the proper functionality of centrosomes and microtubule organization, impacting cell division and the cell cycle.

Overall, the PPP4R3B gene is an important player in cellular regulation and contributes to fundamental biological processes that may have broader implications for health and disease, particularly regarding metabolism and cellular signaling dynamics. Further research may be necessary to elucidate its roles in specific pathophysiological contexts.