### SYNPO Gene Overview

**Gene Symbol:** SYNPO  
**Protein Summary:** The SYNPO gene encodes an actin-associated protein that contributes to the modulation of actin-based structures within dendritic spines and renal podocyte foot processes. It plays a crucial role in the formation of spine apparatuses in telencephalic neurons, which are vital for synaptic plasticity.

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### Additional Information

1. **Associated Genes:**
   While the specific summary does not list associated genes, SYNPO has been studied in the context of various signaling pathways and structural proteins involved in cytoskeletal organization and neuronal function. Some related genes include:
   - **ACTB (Beta-actin):** Involved in actin cytoskeleton formation.
   - **CASK:** Associated with synaptic function and may interact with SYNPO in neurons.
   - **PSD95:** Related to synaptic plasticity and is often studied alongside proteins involved in dendritic spine progression.

2. **Aging and Age-Related Diseases:**
   - SYNPO has not been extensively featured in aging studies directly; however, it is known that abnormalities in dendritic spine morphology and synaptic function are often associated with neurodegenerative diseases such as Alzheimer's disease and related cognitive decline. As such, changes in SYNPO expression may indirectly influence neurodegeneration and cognitive functions related to aging.
   - In renal podocytes, dysfunction might contribute to age-related kidney diseases or conditions like focal segmental glomerulosclerosis (FSGS), which can worsen with age.

3. **Drug Interactions:**
   Currently, there are no specific drugs or drug classes that are well-documented to interact directly with the SYNPO gene or its protein product. However, compounds that target actin dynamics, such as:
   - **Cytochalasins:** which disrupt actin polymerization.
   - **Latrunculin A:** which sequesters actin monomers, potentially could indirectly affect SYNPO function through their impact on the cytoskeletal network.

4. **Pathways and Biological Processes:**
   - SYNPO is involved in several biological processes, including:
     - **Synaptic Plasticity:** Establishment and maintenance of dendritic spines, crucial for memory and learning.
     - **Actin Cytoskeleton Organization:** Modulation of the cytoskeleton, important for cell shape and motility, influencing both neuronal cells and renal podocytes.
     - **Cell Adhesion and Morphogenesis:** Plays a role in the structural integrity of cells and their ability to maintain proper architecture in tissues.
   - SYNPO may be implicated in pathways related to:
     - **Neurotransmission:** Essential for synaptic signaling and plasticity.
     - **Renal Function:** Involved in maintaining the health and function of podocytes, important in kidney filtration.

### Summary
The SYNPO gene encodes a crucial actin-associated protein impacting synaptic function and renal health. Its association with other cytoskeletal proteins positions it at the crossroads of architecture and function in both neurons and podocytes. Although further research is warranted, findings underscore its potential role in neurodegenerative and renal diseases, particularly in the context of aging.