### SNORD114-1 Gene Overview

**Gene Symbol:** SNORD114-1  
**Location:** Human chromosome 14  
**Type:** Small nucleolar RNA (snoRNA)

#### General Function:
SNORD114-1 is a gene that encodes a small nucleolar RNA (snoRNA), which is primarily involved in the modification of other RNAs (particularly ribosomal RNA). Small nucleolar RNAs are key players in the biogenesis and processing of rRNA and play roles in cell growth and maintenance.

### 1. Associated Genes:
While specific gene associations for SNORD114-1 are not commonly detailed in summary databases, snoRNAs often influence the expression and modification of ribosomal proteins and other snoRNAs. Some related genes that have been studied in the context of snoRNAs include:

- **SNORD114** (the broader family of snoRNAs, of which SNORD114-1 is a member)
- **RPS (Ribosomal Protein S)** family genes, such as RPS10, which encodes ribosomal proteins that could be influenced by snoRNA modifications.
- **PRMT5**: a gene associated with some small nucleolar RNAs affecting methylation processes.

### 2. Aging and Age-Related Diseases:
Research specifically linking SNORD114-1 to aging or age-related diseases is relatively limited. However, snoRNAs have been implicated in various cellular processes, including those pertinent to aging. For example, dysregulation of snoRNAs has been observed in certain age-related conditions such as:

- **Cancer**: Some studies have indicated that snoRNA expression profiles may correlate with the aggressiveness of certain cancers as well as senescence.
- **Neurodegenerative diseases**: Alterations in snoRNA expression may also be related to neurodegenerative conditions, although specific links to SNORD114-1 have not been well-defined.

### 3. Drug Interactions:
There is currently no specific information on drugs or drug classes that interact directly with SNORD114-1. However, drugs affecting RNA biogenesis or processing (like ones targeting RNA polymerase or ribosomes) may indirectly influence the function of snoRNAs, including SNORD114-1. This could include:

- **Antibiotics** that target ribosomal RNA synthesis, e.g., certain aminoglycosides or tetracyclines.
- **Cancer therapeutics** targeting mRNA translation or processing may also impact the function of snoRNAs.

### 4. Pathways and Biological Processes:
SNORD114-1 is involved in several critical biological processes, including:

- **rRNA modifications**: SNORD114-1 is part of the machinery responsible for methylation and pseudouridylation of rRNA, which is essential for ribosome function.
- **Ribosome biogenesis**: Contributions to the assembly and processing of ribosomal subunits.
- **Cell proliferation**: Given its role in rRNA processing, it likely has implications in cellular growth and proliferation mechanisms.
- **RNA methylation**: Contributes to the broader context of RNA methylation, impacting gene expression regulation.

### Conclusion:
In summary, SNORD114-1 is a small nucleolar RNA that plays a significant role in RNA modification processes critical for ribosomal function, with potential implications in aging and age-related diseases, though direct associations need further exploration. While drug interactions are not specifically defined, its biological role suggests indirect effects from RNA-processing drugs. Further research could elucidate its significance in longevity and disease contexts alongside associated genes and pathways.