### TPD52L3 Gene Overview

**Gene Symbol:** TPD52L3  
**Chromosomal Location:** Human chromosome 3 (3p21.31)  
**Entrez Gene ID:** [7291](https://www.ncbi.nlm.nih.gov/gene/7291)  

TPD52L3 encodes a protein that is part of the tumor protein D52-like family of proteins. These proteins are involved in various cellular processes and are particularly noted for their role in the formation of complexes through coiled-coil structures. TPD52L3 is predominantly expressed in the testis, with levels significantly higher in adult compared to fetal tissues, suggesting a role in spermatogenesis.

### 1. Associated Genes
While specific direct associations are less commonly detailed in gene summaries, TPD52L3 is typically linked with other members of the TPD52 family, such as:
- **TPD52** (Tumor Protein D52)
- **TPD52L1** (Tumor Protein D52-like 1)
- **TPD52L2** (Tumor Protein D52-like 2)

Additionally, it may exhibit interactions with other genes involved in testicular function or spermatogenesis.

### 2. Aging and Age-Related Diseases
Currently, there is no direct evidence or strong associations in the literature linking TPD52L3 to aging or age-related diseases. However, given its expression in testicular tissues, any potential age-related decline in spermatogenesis could hypothetically implicate TPD52L3 in age-related fertility issues or decline in testis function with age. Research on the role of the TPD52 family members in cancer may also provide indirect associations, as the risk of certain malignancies can increase with aging.

### 3. Drug/Drug Classes Interaction
As of now, there are no well-documented drugs or drug classes that interact specifically with TPD52L3 directly. However, it could be beneficial to research any targeted therapies in cancer that affect the pathways involved with TPD52 family proteins, particularly in testicular cancer or reproductive health.

### 4. Pathways and Biological Processes
TPD52L3 is involved in several biological processes, including:
- **Spermatogenesis:** Its testis-specific expression and higher levels in adult tissue suggest a pivotal role in male reproductive biology.
- **Regulation of Gene Expression:** Being a member of the TPD52 family, it may be involved in transcriptional or translational control processes.
- **Cellular Protein Complex Formation:** Due to its coiled-coil domain, it is likely involved in forming protein complexes necessary for specific cellular functions.

**Potential Pathways:** While specific pathways have not been extensively categorized for TPD52L3, it may interact in larger biological pathways relevant to:
- **Cell Cycle Regulation:** Participation in cell signaling associated with the transition of germ cells.
- **Testis Function:** Pathways regulating spermatogenesis and male fertility.

### Conclusion
TPD52L3 is a gene with specific roles in male reproductive biology, particularly spermatogenesis, evidenced by its testis-specific expression. Further research may elucidate its broader role in health and disease, particularly concerning aging and potential drug interactions.