### ABCC3 Gene Overview

**Gene Symbol:** ABCC3  
**Location:** Chromosome 17 (17q21.2)

#### Protein Function:
ABCC3 encodes a protein that belongs to the ATP-binding cassette (ABC) transporter superfamily, specifically the MRP (multidrug resistance protein) subfamily. This protein is involved in the ATP-dependent transport of various substances across cellular membranes, including organic anions, drugs, toxicants, and endogenous compounds. It has a key role in the biliary and intestinal excretion of these substances, which contributes to detoxification processes.

**Main Activities of ABCC3:**
- Transports glucuronide-conjugated compounds (e.g., bilirubin diglucuronide, estradiol-17-beta-o-glucuronide).
- Transports glutathione conjugates and various bile salts.
- Involved in the development of multi-drug resistance in cancer cells against drugs like methotrexate and etoposide.
- May regulate the transport of organic compounds in the testes across the blood-testis barrier.

### 1. Associated Genes
ABCC3 has been associated with several other genes, particularly those involved in drug metabolism, transport, and resistance, as well as various signaling pathways. Notable associations may include:
- **ABCC1 and ABCC2:** Other members of the MRP subfamily that also contribute to drug resistance.
- **SLC family members:** Such as SLC22A and SLC10A, involved in the transport of organic anions and drugs.
- **UGT family (e.g., UGT1A1):** Involved in the glucuronidation process that prepares compounds for excretion.

### 2. Aging and Age-Related Diseases
While specific mentions of ABCC3 directly related to aging or age-related diseases are limited, the involvement of ABC transporters in drug disposition, metabolism, and clearance can have implications in age-related pharmacokinetic changes. As aging influences liver function and the expression of various transporters, ABCC3 may contribute to:
- Altered drug metabolism and clearance in older adults, potentially impacting the efficacy and toxicity of medications.
- Increased susceptibility to cholestasis-related conditions by governing bile acid levels, which may become significant in the aging population.

### 3. Drug Interactions
ABCC3 is known to interact with several drug classes and specific drugs, including:
- **Anticancer Drugs:** Contributes to resistance against methotrexate, tenoposide, and etoposide.
- **Non-steroidal Anti-inflammatory Drugs (NSAIDs):** Specific interactions may vary, but the transporter is known to affect the clearance of various NSAIDs.
- **Antiretroviral Drugs:** Can influence the pharmacokinetics of certain AIDS therapies.
- **Bile Acid Sequestrants:** Regulates bile salt levels in circulation which can interact with antihyperlipidemic drugs.

### 4. Pathways and Biological Processes
ABCC3 is involved in various biological processes and signaling pathways, including:
- **Drug Transport:** Acts as an efflux transporter for the export of xenobiotics and therapeutic agents from cells.
- **Hepatic Excretion:** Facilitates the excretion of organic anions and bile acids from hepatocytes, contributing to bile formation and detoxification.
- **Cellular Detoxification:** Plays a role in the transport of toxic substances thereby protecting cells from cytotoxic effects.
- **Transport of Compounds in Tissues:** May influence the movement of organic compounds across barriers such as the blood-testis barrier.

### Summary
ABCC3 is a vital transporter involved in drug metabolism and resistance, bile acid transport, and the detoxification process. Its associations with other transport and metabolism genes, significance in age-related pharmacokinetics, and interaction with various drug classes underscore its importance in clinical and pharmacological contexts. Further research may elucidate its role in aging and disease pathology more comprehensively.