### ZNF653 Gene Overview

**Gene Symbol**: ZNF653  
**Location**: The ZNF653 gene encodes a zinc finger protein that acts as a transcriptional repressor. Its activity is primarily associated with nuclear functions, where it influences gene expression through interactions with other transcription factors.

#### Function
- **Binding Activity**: ZNF653 is known to enable AF-2 domain binding activity and transcription corepressor activity.
- **Regulatory Roles**: It is involved in the extracellular negative regulation of signal transduction and the negative regulation of nucleic acid-templated transcription. 
- **Target Genes**: Known targets for repression by ZNF653 include NR5A1, PPARG, NR1H3, NR4A2, ESR1, and NR3C1.

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### 1. Associated Genes
While the summaries provided only mention a few target genes, ZNF653 may have interactions with other genes involved in similar pathways, particularly transcription factors and genes in metabolic pathways. However, specific details about additional associated genes are less defined in the literature. Possible additional associated genes might include other members of the zinc finger protein family, as well as those involved in pathways that intersect with nuclear receptor action.

### 2. Aging and Age-Related Diseases
Current research on ZNF653 in the context of aging or age-related diseases is limited. However, given that it may repress important receptors involved in metabolic and developmental processes (such as NR5A1 and PPARG), altered expression or dysregulation of ZNF653 could potentially influence age-related conditions like obesity, metabolic syndrome, and possibly cancer. Investigating the impact of ZNF653 on cellular senescence and inflammation may reveal more about its role in aging.

### 3. Drug Interactions
There is currently no specific information available regarding drugs or drug classes that directly interact with the ZNF653 gene. However, considering its role as a transcriptional repressor, potential downstream effects may influence responses to hormones or drugs that target the nuclear receptors ZNF653 interacts with (e.g., corticosteroids and metabolic modulators).

### 4. Pathways and Biological Processes
ZNF653 is involved in several biological processes, including:
- **Transcription Regulation Pathways**: ZNF653 could be part of regulatory networks involving transcription factors and hormonal signaling.
- **Signal Transduction**: Its role in the negative regulation of signal transduction may connect it to pathways related to growth factors and metabolic signals.
- **Nuclear Receptor Pathways**: Given its repressive role on nuclear receptors (like NR5A1, PPARG), it likely participates in gene expression pathways influenced by steroid hormones, sex hormones, and metabolic signals.

Further exploration in model systems and human studies may elucidate the complexity of ZNF653’s regulation and its potential implications in health and disease.

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### Conclusion
ZNF653 represents a significant regulatory node within gene expression and cellular signaling pathways. While specific associations and interactions are still being explored, its functional capacity as a transcriptional repressor provides it with potential importance in various biological and physiological contexts. Research into its specific roles, particularly in aging and disease, could yield valuable insights into therapeutic targets or biomarkers.