### TMEM147-AS1 Gene Overview

**Gene Symbol**: TMEM147-AS1  
**Entrez Gene ID**: 100035971  
**Location**: Chromosome 1, Long arm   

TMEM147-AS1 is classified as a long non-coding RNA (lncRNA) and is a part of the host gene TMEM147, which is known to play a role in various biological processes. The lncRNA itself is thought to have regulatory roles in gene expression, but detailed functional studies are still emerging.

### 1. Associated Genes
TMEM147-AS1 has potential associations with several genes involved in various pathways. While specific associations might not be explicitly detailed in the provided summaries, lncRNAs often co-express with nearby coding genes. Genes that could be associated are:

- **TMEM147**: As the host gene, TMEM147 may interact functionally, especially in terms of cellular mechanisms and pathways that the lncRNA could influence.
- **CENPN (Centromere Protein N)**: This gene has been linked to DNA repair and cell cycle, which may be relevant given the potential regulatory effects of TMEM147-AS1.
- **Other genes may include proteins involved in cellular responses to stress or signaling pathways that regulate growth and development, but specific databases or studies should be consulted for a comprehensive list.

### 2. Aging or Age-Related Diseases
Current research surrounding TMEM147-AS1 in relation to aging or age-related diseases is limited. However, long non-coding RNAs are generally implicated in the regulation of processes related to cell senescence, inflammation, and stress responses—pathways enhanced during aging:

- **Potential Senescence Regulation**: If TMEM147-AS1 is regulatory, it might influence aging-related genes.
- **Association with Diseases**: Some studies suggest lncRNAs can be involved in diseases like cancer, cardiovascular diseases, and neurodegenerative disorders, which are often associated with aging.

### 3. Drug Interactions
As of the latest information, specific drugs or drug classes directly interacting with TMEM147-AS1 have not been widely characterized. Long non-coding RNAs are generally not direct targets of pharmacological agents but can influence pathways that may be relevant in:

- **Chemotherapy**: Some lncRNAs are modulated in response to cancer treatments, suggesting possible indirect interactions.
- **Cardiovascular Drugs**: If implicated in stress responses or cellular regulation of cardiovascular systems, lncRNA dysregulation could influence therapeutic responses.

### 4. Pathways and Biological Processes
TMEM147-AS1 might be involved in several biological processes and cellular pathways, reflective of lncRNAs:

- **Gene Expression Regulation**: As a non-coding RNA, it may influence transcriptional regulation.
- **Cell Proliferation and Growth**: Long non-coding RNAs can be modulators in pathways governing cellular growth and development, likely implicating TMEM147-AS1.
- **Response to Environmental Stimuli**: The gene could be involved in the cellular response to stress or damage, especially given its connection to nearby protein-coding genes that regulate these processes.

To explore detailed molecular pathways linked to the function of TMEM147-AS1, bioinformatic tools and databases such as KEGG pathways and Pathway Commons can be utilized. Further empirical studies are necessary to understand its roles concretely.

### Conclusion
TMEM147-AS1 remains a gene of interest due to its potential implications in regulatory networks associated with aging and various diseases. For a deeper understanding of its precise functions and associations, further research and specific experimental investigations are critical.