### Gene Overview: SNORD114-26

**Gene Symbol**: SNORD114-26  
**Gene Type**: Small nucleolar RNA (snoRNA)  
**Location**: Chromosome 14 (14q32)  
**Function**: SNORD114-26 is a member of the SNORD114 cluster of snoRNAs, which are primarily involved in the modification of other RNA molecules, particularly rRNA. They facilitate the process of methylation and pseudouridylation, essential for the proper function of ribosomes in protein synthesis.

### 1. Associated Genes
While specific associations may not always be highlighted, snoRNAs, including SNORD114-26, can be linked to the regulation of several target genes and processes, particularly those involved with ribosomal RNA modification and gene expression. Specifically, they might interact with:
- **RPL (Ribosomal Protein L)** family genes
- **Methyltransferases** involved in RNA modification

### 2. Aging and Age-Related Diseases
Research is emerging that connects snoRNA expression profiles with aging and age-related diseases. While direct associations with SNORD114-26 may be limited, it is important to note that changes in the expression of snoRNAs, including those in the SNORD114 family, can affect cellular aging and may contribute to:
- **Neurodegenerative diseases**: Altered expression of snoRNAs has been observed in conditions like Alzheimer's disease.
- **Cancer**: Some snoRNAs have been shown to have roles in tumorigenesis and cellular senescence.
- **Metabolic disorders**: Dysregulation in snoRNA expression can impact metabolic rate and function.

### 3. Drug Interactions
As of the latest data, there are no specific drugs or drug classes directly known to interact with SNORD114-26. However, since many snoRNAs play roles in cellular processes that could be targeted therapeutically (like cancer pathways), the modulation of snoRNA activity through pharmacological means is an area of active research. Further exploration may identify indirect drug associations.

### 4. Pathways and Biological Processes
SNORD114-26 is involved in the following biological processes:
- **Ribosome biogenesis**: It plays a role in the assembly and maturation of ribosomes, essential for protein synthesis.
- **RNA modification**: SNORD114-26 is involved in the 2'-O-methylation of ribosomal RNA, which is crucial for ribosome stability and function.
- **Cellular response to stress**: Variations in snoRNA expression can influence cellular responses to various stressors, impacting overall cell health and function.

### Summary
SNORD114-26 is a small nucleolar RNA that participates in critical cellular functions, particularly in RNA modification and ribosome biogenesis. While its specific interactions, especially concerning aging and disease, are still being explored, it represents an important area of research with potential implications in understanding cellular aging and cancer biology. As the scientific focus continues to evolve, further studies may elucidate its role across various contexts in human health.