### GOT2P3 Gene Overview

**Gene Symbol:** GOT2P3  
**Description:** GOT2P3 is a pseudogene of the glutamate oxaloacetate transaminase 2 (GOT2) enzyme, also known as mitochondrial aspartate aminotransferase, which plays a crucial role in amino acid metabolism and the malate-aspartate shuttle.

### 1. Associated Genes

As a pseudogene, GOT2P3 does not typically encode a functional protein, but it is often associated with genes involved in amino acid metabolism and mitochondrial function. Related genes may include:

- **GOT2**: The parent gene encoding the mitochondrial isoform of aspartate transaminase.
- **GOT1**: The cytosolic isoform that works in conjunction with GOT2 for amino acid and nitrogen metabolism.
- **IDH1/IDH2** (isocitrate dehydrogenase): Involved in the citric acid cycle and cellular metabolism.

### 2. Aging and Age-Related Diseases

While specific studies focusing on GOT2P3 might be limited due to its status as a pseudogene, its functional counterparts, particularly GOT2, have been implicated in metabolic processes related to aging. Dysregulation of amino acid metabolism and mitochondrial function is often observed in age-related diseases such as:

- **Alzheimer's Disease**: Impaired mitochondrial function and altered amino acid levels can contribute to neurodegenerative processes.
- **Age-related Muscle Loss (Sarcopenia)**: Amino acid metabolism plays a role in muscle maintenance and regeneration.
- **Metabolic Syndrome**: Aspects of metabolic regulation and mitochondrial dysfunction are central to understanding aging and metabolic disorders.

### 3. Drug Interactions

There may not be specific drugs that directly interact with GOT2P3 since it is a pseudogene and does not produce a functional protein. However, drugs affecting GOT2 or mitochondrial function may indirectly relate to the pathways in which GOT2P3 is involved. 

Potential drug classes that could be relevant include:

- **Mitochondrial Protectants**: Such as Rifaximin or Coenzyme Q10, which are used to support mitochondrial function.
- **Antimetabolites**: Certain drugs that interfere with amino acid synthesis may indirectly impact the activity of proteins encoded by GOT-related genes.

### 4. Pathways and Biological Processes

GOT2P3 is thought to be involved in metabolic pathways related to:

- **Amino Acid Metabolism**: Particularly in the conversion of aspartate and α-ketoglutarate to glutamate and oxaloacetate.
- **Malate-Aspartate Shuttle**: This is critical in the transport of reducing equivalents across the mitochondrial membrane, linking glycolysis and oxidative phosphorylation.
- **Urea Cycle**: Potential involvement in nitrogen metabolism links to energy generation.

### Summary

GOT2P3 is a pseudogene related to mitochondrial amino acid metabolism and potentially associated with various biological processes pertinent to aging and metabolic health. While it does not express a protein, understanding its relationship to functional genes such as GOT2 provides insights into its relevance in metabolic pathways and possible associations with age-related diseases.