### CDHR3 Gene Overview

**Gene Symbol:** CDHR3  
**Location:** The CDHR3 gene is located on chromosome 10, specifically at 10q21.1.  

**Function:**  
CDHR3 (Cadherin-related family member 3) encodes a protein that is a member of the cadherin superfamily, known for their roles in cell adhesion. The protein is predicted to have cadherin binding activity and calcium ion binding activity, contributing to calcium-dependent cell-cell adhesion. It plays a significant role in various biological processes including:

- **Cell Morphogenesis**: Involves the development and structure of cells.
- **Cell-Cell Junction Organization**: Important for maintaining tissue architecture and integrity.

The protein is localized in the plasma membrane and is involved in establishing and maintaining cell-cell junctions.

### 1. Associated Genes:

While specific associations may not always be explicitly highlighted in databases, some genes that have been studied alongside or relative to CDHR3 include:

- **CDH1**: Classic cadherin involved in epithelial adhesion.
- **CDH2**: N-cadherin, involved in neuronal and mesenchymal adhesion.
- **VEGFA**: Vascular endothelial growth factor A; pertinent to endothelial cell function.

### 2. Aging and Age-Related Diseases:

Research on the specific role of CDHR3 in aging or age-related diseases is limited. However, cadherins in general have been implicated in processes such as:

- **Neurodegeneration**: Changes in cadherin expression and function can affect synaptic connectivity, which may be relevant in age-related cognitive decline.
- **Cancer**: Altered cadherin expression (especially E-cadherin) has been associated with increased cancer cell invasiveness and metastasis, a potential link with age-related susceptibility to cancer.

Some studies suggest that CDHR3 polymorphisms could have implications in the development of respiratory diseases and conditions, which might be exacerbated with age.

### 3. Drug Interactions:

As of now, there is no direct evidence of specific drugs or drug classes that interact with the CDHR3 gene or its protein product. However, cadherin-based targets are sometimes considered in therapeutics for conditions involving cellular adhesion, cancer, and tissue regeneration. Further research would be needed to identify any potential pharmacological interventions targeting CDHR3.

### 4. Pathways and Biological Processes:

CDHR3 is likely involved in several key biological pathways, including but not limited to:

- **Calcium Signaling Pathways**: Given its predicted calcium ion binding activity.
- **Adherens Junctions**: A significant aspect of maintaining cell-cell adhesion.
- **Cell Adhesion Molecules (CAMs)**: Influencing cellular communication and integrity within epithelial tissues.

### Conclusion

In summary, the CDHR3 gene encodes a cadherin-related protein that plays crucial roles in cell adhesion and junction organization. Its associations with other cadherin family members, implications in potential age-related effects, and involvement in various biological pathways underline its importance in cellular architecture and tissue biology. Further research may provide deeper insights into its role in health and disease.