### GPR142 Gene Overview

**Gene Symbol:** GPR142  
**Protein Summary:** GPR142 is classified as an orphan receptor, indicating that its endogenous ligand is not yet identified. Orphan receptors are a subset of G protein-coupled receptors (GPCRs) that play roles in various physiological processes.

#### 1. Associated Genes
GPR142 may interact with various other genes, particularly those involved in G protein signaling pathways, cell signaling, and neurobiology. Some genes that have been associated with GPR142 through expression studies and potential functional pathways include:

- **ADRB2** (Beta-2 adrenergic receptor)
- **GRIN1** (Glutamate ionotropic receptor NMDA type subunit 1)
- **SLC6A20** (Sodium-dependent neutral amino acid transporter)

The list of associated genes may not be exhaustive, and ongoing research may yield additional genes that show co-expression or have functional relationships with GPR142.

#### 2. Aging and Age-Related Disease Associations
There is limited direct evidence linking GPR142 to aging or age-related diseases as of the latest information available up to October 2023. However, GPCRs in general, including orphan receptors like GPR142, are implicated in various aging processes, including inflammation, metabolism, and neurodegenerative diseases. Alterations in GPCR signaling pathways can contribute to the dysregulation observed in age-related pathologies, such as:

- Alzheimer's disease
- Cardiovascular aging
- Reduced metabolic function

Further research is necessary to delineate the specific roles of GPR142 in these contexts.

#### 3. Drug Interactions
As of October 2023, there are no specific drugs or drug classes that are definitively known to interact directly with GPR142. However, since it is an orphan receptor, this suggests that ongoing pharmacological studies may eventually identify ligands or drug candidates that might act through this receptor or influence its pathways.

#### 4. Biological Pathways and Processes
GPR142 is implicated in several biological pathways and processes, although detailed comprehensive data is still under active investigation. Some of the known roles include:

- **G protein-coupled receptor signaling pathways**: GPR142 interacts with various G proteins (though specific G proteins remain to be identified) that can transduce signals influencing cell behavior.
- **Neurosensory processes**: As an orphan receptor, it may be involved in sensory perception and neuronal signaling, though specific pathways related to sensory information have not been clearly elucidated.
- **Potential role in metabolic regulation**: Given its status as a GPCR, GPR142 might be associated with pathways related to metabolism and energy homeostasis.

### Conclusion
GPR142 remains an intriguing gene due to its status as an orphan receptor. While many details about its interactions, biological roles, and implications in health and disease are still unclear or under research, it represents a potential area of interest for future studies in pharmacology, neurobiology, and gerontology. Emerging studies may provide new insights into its functions and therapeutic potentials.