### Gene Summary
**Gene Symbol:** PRKAR1B-AS1  
PRKAR1B-AS1 is an antisense RNA gene located on chromosome 17. It is associated with the regulation of the PRKAR1B gene, which encodes a regulatory subunit of protein kinase A (PKA), involved in various signaling pathways. 

### Association with Other Genes
While PRKAR1B-AS1 primarily regulates PRKAR1B, it may also be associated with nearby and functionally related genes. However, specific genes not mentioned in the summaries that have been shown to interact or co-express with PRKAR1B-AS1 include:

- **PRKAR1A** - A regulatory subunit involved in protein kinase A signaling.
- **PRKACA** - Another regulatory component of protein kinase A.
- Nearby genes and transcripts such as **ADAMTSL1** and **TDRD7** may also be considered, depending on expression patterns in specific tissues.

### Aging and Age-Related Disease Associations
Research connecting PRKAR1B-AS1 to aging is still emerging. However, as a regulator of PRKAR1B, which is involved in the protein kinase A signaling pathway, its involvement in cellular aging and stress response has been suggested. PKA activity has been implicated in processes related to:

- **Cellular senescence** - Altered signaling through PKA can affect the senescence of cells, impacting tissue regeneration and aging.
- **Age-related diseases** - Dysregulation of PKA signaling may correlate with conditions such as cancer, metabolic syndrome, and neurodegenerative disorders.

### Interactions with Drugs or Drug Classes
While specific drugs directly targeting PRKAR1B-AS1 have not been identified, drugs interacting with the PKA signaling pathway may indirectly affect the expression or activity associated with PRKAR1B-AS1. Notable examples include:

- **cAMP modulators**, such as **rolipram** (a phosphodiesterase inhibitor), that increase intracellular levels of cAMP, activating PKA.
- **Beta-adrenergic antagonists**, which can modulate signaling pathways that involve PKA.
  
These drugs can have downstream effects on PKA-related pathways that may also influence PRKAR1B-AS1 expression or activity.

### Pathways and Biological Processes
PRKAR1B-AS1 is involved in several key biological processes and pathways:

- **Regulation of Protein Kinase A (PKA) Signaling** - It helps modulate the activity of PRKAR1B, impacting downstream PKA signaling.
- **Cell Growth and Proliferation** - Through its influence on PKA, it affects cellular responses crucial for growth and replication.
- **Metabolic Regulation** - PKA signaling pathways play essential roles in glucose metabolism and lipid regulation.
- **Stress Responses** - PKA is involved in pathways responding to stress, including those regulating cell survival under adverse conditions.

Further research is ongoing to elucidate the complete role of PRKAR1B-AS1 in these biological contexts and its implications in health and disease.