### RPS3AP28 Gene Overview

**Gene Symbol:** RPS3AP28  
**Location:** Located on chromosome 3 in humans.  
**Function:** RPS3AP28 is a pseudogene that is involved in the regulation and function of ribosomal proteins, which are essential for protein synthesis.

### 1. Associated Genes
RPS3AP28 is linked to various other genes, particularly those involved in ribosomal function and protein synthesis. Additional genes that may show some level of association or functional interaction include:
- **RPS3** (Ribosomal Protein S3) - Though part of a distinct gene family, it is closely related to the functions that RPS3AP28 is likely to influence.
- **RPL10** (Ribosomal Protein L10) and other ribosomal protein genes may also be co-expressed or involved in similar pathways.

### 2. Aging or Age-Related Disease Associations
While there is limited specific information about the direct role of RPS3AP28 in aging or age-related diseases, ribosomal proteins and their associated genes, in general, have been implicated in processes related to cellular aging. Dysregulation of ribosomal biogenesis and protein synthesis has been associated with:
- **Cancer:** Altered expression of ribosomal proteins can contribute to tumorigenesis.
- **Age-related diseases** like neurodegenerative diseases, where protein aggregation and synthesis are often disrupted.

Research into RPS3AP28’s specific linkage to such diseases may still be emerging, and its pseudogenic nature suggests it may have regulatory roles rather than direct coding functions.

### 3. Drug Interactions
Data regarding specific drugs or drug classes that interact directly with RPS3AP28 is limited due to its classification as a pseudogene. While it may not have direct interactions with drugs, it can potentially influence the efficacy of drugs targeting proteins that rely on the ribosomal landscape.

Ribosomal proteins have been implicated in responses to certain classes of drugs, such as:
- **Antibiotics (e.g., aminoglycosides, tetracyclines)** that target the ribosomal machinery.
- **Anticancer agents** that may affect protein synthesis pathways that involve ribosomal activity.

### 4. Pathways and Biological Processes
RPS3AP28 is assumed to be involved in various biological processes related to ribosomal function, including:
- **Ribosome biogenesis** – Important for the formation of ribosomes essential for protein translation.
- **Translation initiation and elongation** – Processes that are fundamental to protein synthesis.
- Other cellular stress responses may be indirectly influenced by this gene, especially in how the ribosomal function adapts under stress conditions.

### Summary
RPS3AP28, while primarily a pseudogene, exhibits relevance through the genetic and functional interactions typical of ribosomal proteins. Its exact role in aging or diseases needs further elucidation, particularly as research regarding the functional implications of pseudogenes grows. Future studies may uncover more about its interactions and regulatory effects on gene expression and protein synthesis, potentially linking it to age-related phenotypes and treatment responses.