### RNU6-145P Gene Overview

**Gene Symbol:** RNU6-145P  
**Type:** Non-coding RNA (specifically a small nucleolar RNA, or snoRNA)

RNU6-145P is a small nucleolar RNA gene that is part of the non-protein-coding RNA class. Small nucleolar RNAs, including RNU6-145P, are primarily involved in the biogenesis and modification of ribosomal RNA (rRNA) and may play roles in other RNA-processing events.

### 1. Associated Genes

RNU6-145P has been linked to multiple genes due to its involvement in RNA processing and potential regulatory functions. While specific gene associations are often not exhaustively cataloged, it may interact indirectly with genes involved in RNA modifications and splicing processes. 

- **Examples of related smaller RNA genes:** Other members of the U6 family of small nuclear RNAs (snRNAs), such as RNU6-1 and RNU6-9, might also exhibit functional relationships or co-regulation that could provide additional context to RNU6-145P's role.

### 2. Aging and Age-Related Diseases

Current research does not extensively characterize RNU6-145P in the specific context of aging or age-related diseases. However, some general points about the involvement of snoRNAs in aging can be highlighted:

- **snoRNA and Aging:** Small nucleolar RNAs have been implicated in various cellular processes, including the regulation of ribosome biogenesis, which can affect cellular capacity and stress responses during aging. Dysregulation of snoRNA may contribute to age-related diseases, such as neurodegenerative diseases, although specific studies linking RNU6-145P directly to aging are limited.

### 3. Drug Interactions

As a non-coding RNA, RNU6-145P does not encode a protein product and therefore does not have a direct interaction with pharmaceuticals. However, the expression levels and functionality of small RNAs can sometimes be indirectly affected by certain classes of drugs that target RNA processing or epigenetic regulation, such as:

- **Antisense oligonucleotides (ASOs):** Designed to modify the expression of specific RNAs.
- **Histone deacetylase inhibitors:** These can affect the general expression levels of non-coding RNAs.

### 4. Pathways and Biological Processes

The RNU6-145P gene may be involved in several biological processes like:

- **Small nucleolar RNA (snoRNA) biogenesis:** It plays a significant role in the processing and maturation of ribosomal RNA.
- **RNA modification:** Involved in post-transcriptional modifications of RNA components.
- **Pre-mRNA splicing:** Given its classification, it may also participate in the regulatory mechanisms associated with pre-mRNA splicing and other RNA processing steps.

### Conclusion

Overall, RNU6-145P represents an important element of the non-coding RNA landscape in eukaryotic cells, potentially influencing multiple biological systems through its role in RNA processing. More targeted research is needed to fully understand its implications in aging, disease, and pharmacology.