### CLEC14A Gene Overview

**Gene Symbol:** CLEC14A  
**Location:** The CLEC14A gene is located on chromosome 6 in humans.  

**Function:** CLEC14A encodes a protein that belongs to the C-type lectin superfamily, which is involved in a variety of cellular processes including cell adhesion, cell-cell signalling, and glycoprotein turnover. It is particularly noted for its role in angiogenesis, which is the formation of new blood vessels, and is involved in processes such as filopodia formation, cell migration, and tube formation. As it is upregulated in tumor vascular endothelial cells compared to normal endothelial cells, it is a candidate for targeting in cancer therapies.

### 1. Associated Genes
CLEC14A may interact or be co-expressed with several other genes related to angiogenesis, immune response, and cell adhesion. While specific genes may not always be consistently reported, some candidates that have been identified to interact with or are functionally related to CLEC14A include:
- **VEGFA (Vascular Endothelial Growth Factor A)** - Angiogenic factor.
- **CD31 (PECAM1)** - Cell adhesion.
- **E-selectin (SELE)** - Involved in the immune response.

### 2. Aging and Age-related Diseases
Research on CLEC14A in relation to aging is still growing, but several points have emerged:
- **Tumor Progression:** The gene's upregulation in tumor-associated vessels may link it to age-related diseases such as cancer, as older individuals have a higher incidence of tumors.
- **Vascular Health:** Given its involvement in angiogenesis and endothelial function, alterations in CLEC14A expression may potentially impact age-related vascular conditions, including atherosclerosis and other cardiovascular diseases, although specific associations are not fully characterized.

### 3. Drugs and Drug Classes
As of my last knowledge update, there were no specific drugs directly targeting CLEC14A reported; however, it is a potential candidate for therapeutic strategies in cancer based on its function in tumor endothelial cells. Drug classes that may influence CLEC14A indirectly include:
- **Angiogenesis Inhibitors:** Such as monoclonal antibodies or small molecules that target VEGF pathways.
- **Immunomodulatory agents:** That could potentially affect its expression or function in inflammatory and immune responses.

### 4. Pathways and Biological Processes
CLEC14A is involved in a number of key biological processes and pathways, including but not limited to:
- **Angiogenesis:** Critical for forming new blood vessels, especially in tumors.
- **Cell Adhesion:** Important for maintaining vascular integrity and function.
- **Endothelial Cell Activation:** Plays a role in inflammation and potentially immune responses.
- **Filopodia Formation:** Affects cell migration and dynamics during morphogenetic events.
- **Wound Healing:** Implicated in processes that restore tissue integrity following injury.

Overall, CLEC14A is a multifaceted gene with significant implications in vascular biology and cancer, representing a focal point for ongoing research in oncology and regenerative medicine.