**SNORA71E Gene Overview:**

- **Gene Symbol**: SNORA71E
- **Gene Type**: Small nucleolar RNA (snoRNA)
- **Function**: The SNORA71E gene encodes a small nucleolar RNA molecule involved in the biogenesis and modification of ribosomal RNA (rRNA). This gene is part of the C/D box snoRNA family, which plays a crucial role in 2'-O-methylation of rRNA and, potentially, other small nuclear RNAs (snRNAs).

### 1. Associated Genes
The SNORA71E gene is often expressed in conjunction with other small nucleolar RNAs, particularly those within the same family (C/D box snoRNA). While specific interactions or associations with other genes are not always directly documented, small nucleolar RNAs frequently work alongside components of the ribosomal biogenesis pathway. Specific snoRNAs frequently associated with SNORA71E include:
- SNORA71A
- SNORA71B
- SNORA71C

In general, the involvement of snoRNAs in ribosomal biogenesis means that genes involved in the processing of rRNA and formation of the ribosome (such as RPS and RPL genes) could be considered functionally linked.

### 2. Aging and Age-Related Diseases
Although specific studies directly linking SNORA71E with aging or age-related diseases are limited, several small nucleolar RNAs, including those in the C/D box family, have been implicated in cellular processes that can influence aging. These processes include:
- Maintenance of ribosomal RNA integrity and function, which is essential for protein synthesis and cellular function.
- Possible involvement in stress responses, as RNA modifications can influence cellular stresses that accumulate with age.

In studies of cellular senescence and age-related pathologies, the dysregulation of snoRNA expression patterns has been noted, potentially linking them to the aging process.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes documented to have direct interactions with SNORA71E. However, research into the therapeutic modulation of snoRNAs is ongoing, particularly in the context of cancer and other diseases where ribosomal biogenesis is disrupted. Some general categories that affect the expression of various snoRNAs include:
- Antineoplastic agents (chemotherapies that may target RNA synthesis pathways).
- Drugs targeting RNA processing mechanisms, although none are specifically tied to SNORA71E.

### 4. Pathways and Biological Processes
SNORA71E is primarily involved in the following biological processes:
- **SnoRNA-mediated ribosome biogenesis**: Facilitating the modification of rRNA.
- **Ribosomal RNA methylation**: SNORA71E likely methylates specific nucleotides within rRNA, which is crucial for ribosome assembly and function.
- **Nuclear pre-mRNA processing**: Related processes where snoRNAs influence splicing mechanisms and the maturation of mRNA.

Further biological pathways that may involve snoRNA function include:
- **Cellular stress response pathways**: Potential influence through rRNA modification.
- **Gene Expression Regulation**: By participating in the modification of snRNAs which can have broader impacts on mRNA processing and availability.

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This summary integrates the structural and functional aspects of the SNORA71E gene, acknowledging its connections to broader biological systems and emphasizing its potential roles in aging and therapeutic contexts.