### RRAS Gene Overview

**Gene Symbol:** RRAS  
**Chromosomal Location:** Located on chromosome 19 in humans.  
**Function:** The RRAS gene encodes a small GTPase that is pivotal in various cellular processes including angiogenesis, vascular homeostasis, cell adhesion, and neuronal axon guidance. It plays a significant role in regulating the actin cytoskeleton organization and modulating the activity of integrin beta-1 (ITGB1) when in complex with OSPBL3.

### 1. Associated Genes
RRAS interacts with various other genes in biological pathways and processes. Notable genes and proteins include:
- **ITGB1 (Integrin beta-1)**: Known to modulate cell adhesion properties.
- **OSBPL3**: Assists RRAS in modulating integrin activity.
- **RAP1B**: Another small GTPase that shares functional associations with RRAS in the regulation of cell adhesion and migration.
- **RHOA, RAC1**: Other members of the Rho family of GTPases that are involved in cytoskeletal organization and signaling pathways.

### 2. Aging and Age-Related Diseases
While specific studies directly linking RRAS with aging are limited, the gene's involvement in angiogenesis and vascular stability can have implications in age-related diseases such as:
- **Atherosclerosis**: As vascular function declines with age, RRAS's role in vascular homeostasis suggests that it may be involved in the pathophysiology of atherosclerosis.
- **Cancer**: Given that mutations in RRAS are frequently found in various types of invasive cancers, its role in tumorigenesis could be indirectly linked to aging, as the risk of cancer increases with age.
- **Neurodegenerative diseases**: Its role in neuronal axon guidance suggests a potential link to new insights in conditions affecting the aging brain, such as Alzheimer’s disease.

### 3. Drug Interactions
While no specific drugs have been explicitly linked to direct interactions with RRAS, small GTPases, including RRAS, can be impacted by:
- **GTPase inhibitors**: These may serve to modulate the activity of small GTPases in experimental settings.
- **Integrin inhibitors**: Since RRAS has a role in integrin beta-1 modulation, pharmacological agents targeting integrins may indirectly affect RRAS pathways.

### 4. Pathways and Biological Processes
RRAS is involved in several critical pathways and biological processes:
- **Angiogenesis**: Essential for new blood vessel formation.
- **Cell adhesion**: Regulates how cells attach to each other and their extracellular matrix.
- **Cytoskeletal rearrangement**: Plays a role in the regulation and organization of the actin cytoskeleton.
- **Cell migration and proliferation**: Important for wound healing and tissue regeneration.
- **Signal transduction**: Engages in intracellular signaling pathways that facilitate various cellular responses.

In summary, RRAS is an important gene with diverse functions in cellular processes and potential implications in age-related diseases and cancer, making it a significant focus for further research in both normal physiology and pathology.