### UHRF1 Gene Overview

**Gene Symbol**: UHRF1  
**Chromosomal Location**: Human chromosome 19p13.2  

#### 1. Associated Genes
UHRF1 is known to interact with a number of genes and proteins that are important in various cellular processes. Some key genes that are associated with UHRF1 include:

- **DNMT1**: DNA methyltransferase 1, recruited by UHRF1 for maintaining DNA methylation during replication.
- **PML**: Promyelocytic leukemia protein, involved in the regulation of various cellular processes and targeted by UHRF1 ubiquitin ligase activity.
- **HIST1H3B**: A histone gene that can be affected by UHRF1-mediated modifications.
- **TOP2A**: Topoisomerase II alpha, a target whose expression is regulated by UHRF1, especially during the G1/S transition.
- **RB1**: The retinoblastoma tumor suppressor, whose expression is also regulated by UHRF1.
- **FANCD2**: Involved in DNA repair processes, specifically interstrand cross-link repair.

#### 2. Aging and Age-Related Diseases
While direct associations of UHRF1 with aging are less well-studied, specific insights suggest the following links:

- **Cancer**: UHRF1 is frequently upregulated in various cancers, suggestive of its role in preventing cellular senescence and promoting tumorigenesis. High levels of UHRF1 can lead to aberrant epigenetic modifications, which are often seen in aged tissues and age-related pathologies.
- **Neurodegenerative Diseases**: Some studies have suggested potential roles of UHRF1 in neurodegenerative conditions, possibly due to its involvement in maintaining genomic integrity and regulating gene expression.

#### 3. Drug or Drug Classes Interactions
While specific drug interactions with UHRF1 are still being explored, certain classes of drugs that target epigenetic modifications may impact UHRF1 activity, including:

- **Histone Deacetylase (HDAC) Inhibitors**: These drugs can influence the chromatin modifications mediated by UHRF1.
- **DNA Methyltransferase Inhibitors**: Compounds such as azacitidine and decitabine can affect methylation patterns, indirectly influencing UHRF1's role.
- **Proteasome Inhibitors**: Since UHRF1 has E3 ligase activity, its regulation could be affected by drugs that alter protein degradation pathways.

#### 4. Pathways and Biological Processes
UHRF1 is involved in several crucial biological pathways and processes:

- **DNA Methylation Maintenance**: UHRF1 plays a central role in the maintenance of DNA methylation patterns during DNA replication.
- **Chromatin Remodeling**: Through its interactions with various chromatin-associated proteins, UHRF1 is involved in both the remodeling of chromatin and the modification of histones.
- **Cell Cycle Regulation**: Specifically, UHRF1 is crucial during the G1/S transition, impacting the expression of genes involved in cell cycle progression such as TOP2A and RB1.
- **DNA Repair**: UHRF1 cooperates with factors like FANCD2 in DNA damage response and repair pathways, ensuring the recognition and resolution of DNA lesions.

In summary, the UHRF1 gene is a multidomain protein playing a significant role in epigenetic regulation, cell cycle control, and DNA repair processes. Its implications in cancer biology and potential connections to aging and age-related diseases highlight its significance in both basic and applied biomedical research.