### FPR3 Gene Overview

**Gene Symbol**: FPR3  
**Gene Description**: The FPR3 gene encodes a low-affinity receptor for N-formyl-methionyl peptides, which are essential for neutrophil chemotaxis. Its main functions include signaling pathways mediated by G-proteins and activating responses in neutrophils upon binding to its ligands.

### 1. Related Genes
FPR3 is part of a gene family that includes several other formyl peptide receptors, such as:
- **FPR1**: The high-affinity receptor for N-formyl peptides, primarily mediating neutrophil responses.
- **FPR2**: Another receptor for N-formyl peptides and also responds to other ligands like lipoxin A4 and annexin A1.
- **FPRL1**: A receptor that is more promiscuous and responds to various ligands involved in inflammation.

### 2. Aging and Age-Related Diseases
While direct links between FPR3 and aging or specific age-related diseases are not extensively documented, the gene is involved in inflammatory responses. Chronic inflammation is implicated in many age-related conditions such as:
- **Atherosclerosis**: Inflammation plays a role in plaque formation, and FPR3 may influence immune cell interactions in arterial walls.
- **Neurodegenerative diseases**: Increased levels of formyl-methionyl peptides have been associated with neuroinflammatory conditions, which may impact diseases like Alzheimer's.

Overall, FPR3 may contribute to the modulation of inflammation, which can affect aging and the progression of various diseases.

### 3. Drug Interactions
There are no specific drugs universally recognized as direct interactors with the FPR3 gene. However, drugs targeting G-protein-coupled receptors (GPCRs) or anti-inflammatory drugs may influence FPR3-mediated pathways indirectly. Examples of drug classes that may be implicated include:
- **Anti-inflammatory agents**: These drugs may modulate pathways activated by FPR3 during inflammatory responses.
- **GPCR modulators**: Drugs that act on related GPCR pathways might impact FPR3's functions.

Research is necessary to identify any specific compounds that interact directly with FPR3.

### 4. Pathways and Biological Processes
The FPR3 gene is involved in several critical biological pathways:
- **G Protein-Coupled Receptor (GPCR) Signaling**: FPR3 activates G-proteins, leading to changes in cellular signaling cascades.
- **Phospholipase C (PLC) Pathway**: Upon activation, it engages the phosphatidylinositol-calcium signaling cascade, which increases cytosolic calcium levels, vital for neutrophil activation.
- **Complement Receptor-Mediated Signaling**: FPR3's role in the complement system directs immune responses during inflammation.
- **Chemotaxis**: It facilitates the migration of immune cells toward sites of infection or injury by responding to chemotactic signals.

### Additional Biological Processes
- **Positive Regulation of Cytosolic Calcium Ion Concentration**: FPR3 plays a role in managing calcium levels critical for various cellular functions.
- **Neutrophil Activation**: The receptor mediates processes that lead to the activation of neutrophils, essential for the innate immune response.

### Summary
In summary, the FPR3 gene encodes a receptor integral to the immune response, exhibiting significant roles in inflammation, signaling pathways, and potential associations with age-related conditions and chronic diseases. Further research is needed to enhance our understanding of FPR3's exact role in various biological processes and its therapeutic implications.