### GPR158-AS1 Gene Overview

**Gene Symbol:** GPR158-AS1

GPR158-AS1 is a long non-coding RNA (lncRNA) gene, which is generally involved in various regulatory functions in gene expression and cellular processes. While specific information regarding GPR158-AS1 may not be abundant, here is an overall summary based on the current understanding of lncRNAs and related findings:

#### 1. Associated Genes
GPR158-AS1 may be co-regulated or associated with several genes involved in similar pathways or located in proximity on the genome. While specific associated gene lists can vary in different studies, potential genes that could be indirectly associated with GPR158-AS1 include:

- **GPR158**: As a sense transcript, GPR158-AS1 may regulate the expression of GPR158, which encodes a G protein-coupled receptor implicated in various neurological functions.
- **Other lncRNAs**: Various long non-coding RNAs often have co-expression patterns or common regulatory networks with other lncRNA genes, such as NEAT1, MALAT1, and HOTAIR.

#### 2. Aging and Age-Related Disease Associations
Though specific studies directly linking GPR158-AS1 to aging or age-related diseases may be limited, long non-coding RNAs are generally known to play critical roles in cellular aging, stress responses, and senescence. It is plausible that GPR158-AS1 could be involved in age-related processes such as:

- **Neurodegeneration**: Given the involvement of GPR158 in neurological functions and potential contributions of lncRNAs to neurodegenerative diseases (like Alzheimer's disease), GPR158-AS1 may intersect with pathways of neuronal health and longevity.
- **Cellular Senescence**: Changes in lncRNA expression profiles have been observed in senescent cells, potentially implicating GPR158-AS1 in the regulation of senescence-associated processes.

#### 3. Drug Interactions
At present, there is no specific information on drugs or drug classes that are known to interact with GPR158-AS1. However, the pathways in which it may be implicated could involve pharmacological targets, particularly in neurological or cancer-related contexts given the association with GPR158.

#### 4. Pathways and Biological Processes
GPR158-AS1, as a lncRNA, may be involved in several biological processes, including:

- **Gene Regulation**: lncRNAs like GPR158-AS1 often act as molecular scaffolds or regulators of transcription factors, thus influencing the expression of nearby genes, particularly GPR158.
- **Cell Signaling Pathways**: LncRNAs can interact with protein complexes involved in signaling pathways, potentially impacting pathways related to development, cellular proliferation, and apoptosis.
- **Neurobiology**: Given its association with GPR158, GPR158-AS1 may participate in various neuronal signaling pathways, possibly influencing synaptic functions and plasticity.

In conclusion, while specific details on GPR158-AS1 remain somewhat limited, it is part of a complex network of gene regulation that likely plays a role in neurobiology and can potentially influence aging and associated disorders through its interactions and regulatory functions. Further studies would help elucidate its precise biological roles and clinical implications.