### ADPGK-AS1 Gene Overview

**Gene Symbol:** ADPGK-AS1

**Summary:**
ADPGK-AS1 (ADP-Glycerate Kinase Antisense RNA 1) is a long non-coding RNA (lncRNA) that is transcribed from the opposite strand of the ADPGK gene. Its primary function is still being elucidated, but lncRNAs like ADPGK-AS1 play critical roles in gene regulation, cellular processes, and may be involved in various biological pathways.

#### 1. **Associated Genes:**
ADPGK-AS1 is particularly associated with:

- **ADPGK:** The protein-coding gene for ADP-glycerate kinase, which is involved in the metabolism of carbohydrates and may also play roles in energy metabolism.
- Other nearby or functionally related genes may include those within the same metabolic pathways or those regulating similar biological processes. These could include **PKM2** (Pyruvate Kinase Muscle), **LDHA** (Lactate Dehydrogenase A), and **GAPDH** (Glyceraldehyde-3-Phosphate Dehydrogenase), although these associations may vary based on specific biological contexts.

#### 2. **Aging and Age-related Diseases:**
Research around ADPGK-AS1 and its role in aging or age-related diseases is still emerging. However, lncRNAs, in general, have been implicated in:

- Regulation of cellular senescence and stress responses.
- Modulation of pathways related to age-related conditions such as cancer, cardiovascular diseases, and neurodegeneration.
- Dysregulation of lncRNAs has been linked to aging processes, so while specific studies directly linking ADPGK-AS1 to aging or diseases have yet to be solidified, its role in metabolic processes suggests it could have downstream effects on age-related health.

#### 3. **Drug Interactions:**
Currently, there are no specific drugs or drug classes widely documented to directly interact with ADPGK-AS1. As the understanding of lncRNAs in pharmacology is evolving, it's notable that lncRNAs may affect the expression of genes that can interact with various drugs indirectly. Further research is warranted to elucidate any potential pharmacological interactions.

#### 4. **Pathways and Biological Processes:**
ADPGK-AS1 is thought to be involved in several biological processes, primarily due to its association with the related ADPGK gene and its metabolic activities. Some potential pathways and processes include:

- **Carbohydrate Metabolism:** Regulating intermediates in sugar metabolism and energy production.
- **Cellular Resilience and Response to Stress:** Implicated in pathways that help cells respond to metabolic stressors or changes in energy demand.
- **Gene Regulation Networks:** As a lncRNA, ADPGK-AS1 may interact with chromatin and various transcription factors to modulate the expression of genes involved in metabolism and cellular functions.

### Conclusion
ADPGK-AS1 is a long non-coding RNA that appears to play a multifaceted role in regulating metabolic processes and potentially influencing age-related cellular mechanisms. However, research is ongoing, and more studies are needed to conclusively determine its full spectrum of functions and interactions in the context of aging and disease.