### PSMA2P3 Gene Overview

**Gene Symbol:** PSMA2P3

The PSMA2P3 gene is a pseudogene belonging to the proteasome subunit alpha type family. As a member of the paralogous genes from the PSMA gene family, it shares sequence similarity with an active gene, PSMA2, which encodes a subunit of the 20S core of the proteasome.

#### 1. Associated Genes
While the PSMA2P3 gene is a pseudogene and does not encode a functional protein, it is associated with several other genes that might share similar functions or belong to related families. Notably, **PSMA2** (the functional counterpart) is directly associated. In addition to this, genes such as **PSMA1**, **PSMB1**, and other subunits in the proteasome complex may also bear relevance due to their involvement in the same proteasomal degradation pathways.

#### 2. Details Related to Aging or Age-related Diseases
The PSMA2P3 pseudogene itself may not have direct associations with aging or age-related diseases. However, the proteasome system, of which PSMA2 is a part, is crucial for protein homeostasis. Dysregulation of proteasomal function is known to contribute to the pathophysiology of age-related diseases such as neurodegeneration (e.g., Alzheimer’s disease, Parkinson’s disease) and various cancers. Any potential effects of PSMA2P3 may be inferred indirectly through its more functional homologs and their involvement in age-related processes.

#### 3. Drug or Drug Classes Interaction
PSMA2P3, being a pseudogene, does not have known drug interactions itself. However, drugs that target the proteasome, like **Bortezomib** (a proteasome inhibitor used primarily in cancer therapy) may affect the functionality of its functional counterparts. This may suggest an indirect involvement, especially in the context of diseases where proteasome inhibitors are relevant.

#### 4. Pathways and Biological Processes
While PSMA2P3 does not encode a functional protein and does not participate directly in biological pathways, the related functional gene, PSMA2, plays a critical role in the **proteasome-mediated protein degradation pathway** which is vital for maintaining cellular protein homeostasis, modulating numerous biological processes such as:

- **Protein Catabolism:** Degradation of unneeded, misfolded, or damaged proteins.
- **Cell Cycle Regulation:** Regulating proteins involved in cell cycle progression.
- **Antigen Processing and Presentation:** Involved in the degradation of proteins for MHC class I presentation.

Further studies may shed light on the more precise roles of PSMA2P3, but as of the last update, the gene appears to serve predominantly as a genetic relic rather than an active participant in biological functions.