### CORO1C Gene Overview

**Gene Symbol:** CORO1C  
**Full Name:** Coronin-1C  
**Gene Locus:** Chromosome 2 (2q31.1)

#### Summary:
CORO1C encodes a member of the WD repeat protein family and is involved in various cellular processes, such as directed cell migration, cytoskeletal organization, and organelle dynamics. The protein plays a critical role in signaling through RAC1, endosome dynamics, and cellular proliferation.

#### 1. Associated Genes:
CORO1C has been linked to several other genes and pathways through various interactions. These may include, but are not limited to:

- **RAC1:** A Rho GTPase involved in cell migration and cytoskeletal dynamics.
- **TMCC1:** A protein involved in endoplasmic reticulum (ER) and endosome interactions.
- **ACTB (β-actin):** Key component of the cytoskeleton.
- **VIM (Vimentin):** An intermediate filament protein that provides structural support.
- **MTSS1 (Metastasis Suppressor 1):** Can interact with the cytoskeleton and modulate migration.

#### 2. Aging and Age-Related Diseases:
While direct associations of CORO1C with aging or specific age-related diseases have not been extensively characterized, its role in cell migration, proliferation, and cytoskeletal organization suggests potential implications in age-related conditions such as cancer, neurodegenerative diseases, and tissue degeneration, where cell migration and organization are crucial for maintaining tissue integrity. Additionally, alterations in its function may affect the overall cellular response to senescence and influence age-related cellular decline.

#### 3. Drug Interactions:
As of the current data available, there are limited direct pharmacological interactions specifically targeting CORO1C. However, drugs or drug classes that may indirectly affect the functions of CORO1C through pathways involving RAC1 or cytoskeletal dynamics include:

- **Rho-kinase inhibitors:** Drugs that target signaling pathways involving Rho family GTPases, potentially impacting CORO1C's functions in cell migration (e.g., Y-27632).
- **Microtubule inhibitors:** Drugs like taxanes (e.g., paclitaxel) that may indirectly influence the overall cytoskeletal dynamics in which CORO1C is involved.

#### 4. Pathways and Biological Processes:
CORO1C is implicated in several biological pathways and processes, including, but not limited to:

- **Regulation of the cytoskeleton:** Involvement in polymerization and organization of actin filaments.
- **Endocytosis:** Plays a role in the fission of endosomal membranes, essential for sorting materials.
- **Cellular migration:** Enhance the localization and activation of RAC1 at the leading edge of cells, facilitating motility.
- **Cell proliferation:** Essential for maintaining normal cellular growth and function.
- **Immune response:** Potential roles in the behavior of immune cells regarding migration and phagocytosis.
- **Signal transduction:** Participation in cellular signaling pathways influenced by GTPases.

### Summary
In summary, CORO1C is a multifunctional gene part of essential cellular processes, particularly cell migration and cytoskeletal organization. Its interactions with other key proteins underline its significance in various signaling pathways, and though its implications in aging are not extensively studied, its roles in cell dynamics suggest it may influence age-related physiological changes. Further research may clarify its role as a potential target in therapeutic avenues related to age-associated diseases.