### FMNL3 Gene Overview

**Gene Symbol**: FMNL3  
**Chromosomal Location**: Human chromosome 3q26.1  

**Function**: The FMNL3 gene encodes a protein that is a member of the formin family, which is involved in the regulation of the cytoskeleton. It primarily plays roles in maintaining cell morphology, cell migration, and organizing actin filament assembly. FMNL3 is also crucial for developmental angiogenesis, where it contributes to microtubule reorganization and endothelial cell elongation.

### 1. Associated Genes

FMNL3 is associated with various genes involved in cytoskeletal dynamics, cellular signaling, and endothelial function. Some notable associated genes include:

- **Rho GTPases (e.g., RHOA, RAC1)**: Both RhoA and Rac1 are critical regulators of the actin cytoskeleton and are known to interact with formins, including FMNL3, to facilitate actin polymerization and organization.
- **VEGF (Vascular Endothelial Growth Factor)**: As FMNL3 is involved in angiogenesis, it may work alongside VEGF signaling pathways which are crucial for endothelial cell function and blood vessel formation.
- **PDGFRB (Platelet-Derived Growth Factor Receptor Beta)**: This receptor is implicated in signaling pathways that promote angiogenesis and could interact with FMNL3 in endothelial cells.

### 2. Aging and Age-Related Diseases

Although specific studies directly linking FMNL3 to aging or age-related diseases might be limited, its role in angiogenesis and cytoskeletal dynamics suggests implications in age-related vascular changes:

- **Cardiovascular Diseases**: With aging, the efficiency of angiogenesis diminishes, which may involve FMNL3's functions in endothelial cell morphology and migration. Disruption in these processes can lead to age-related cardiovascular complications.
- **Cancer**: FMNL3 has been implicated in tumorigenesis through its role in cell migration and invasion, which might contribute to the increased risk of cancer with advancing age.

### 3. Drug Interactions

There are no specific drugs solely targeting FMNL3 reported. However, certain classes of drugs that influence Rho GTPase signaling pathways (e.g., Rho inhibitors) may indirectly affect FMNL3 activity. As a wider categorization, potential drug classes could include:

- **Rho-kinase inhibitors (e.g., Y-27632)**: Rho-kinase plays a significant role in cytoskeletal dynamics and may influence downstream signaling affecting FMNL3.

### 4. Pathways and Biological Processes

FMNL3 is involved in several critical biological pathways and processes:

- **Actin Cytoskeleton Organization**: FMNL3 directly influences the polymerization of actin filaments, critical for various cellular functions including motility and morphology.
- **Endothelial Tube Formation**: FMNL3 is necessary for the formation of blood vessels during angiogenesis, including mechanisms like tubular morphogenesis.
- **Cell Migration**: It regulates cell movement, particularly within endothelial cells, important for processes like wound healing and development.
- **Cancer Metastasis**: By promoting cell migration, FMNL3 may play a role in cancer progression and metastasis.

### Summary

The FMNL3 gene is integral to cytoskeletal organization, angiogenesis, and cell migration. It interacts with multiple signaling pathways and is associated with a variety of genes that influence vascular health and cellular dynamics. While there is a need for further investigation into its specific roles in aging and drug interactions, its importance in cell shape regulation and migration highlights its potential relevance in age-related diseases and cancer.