### PLCE1-AS1 Gene Overview

**Gene Symbol**: PLCE1-AS1  
**Gene Type**: Long non-coding RNA (lncRNA)  
**Chromosomal Location**: Human chromosome 10 (10q26.3)

### General Functions

PLCE1-AS1 is an antisense long non-coding RNA associated with the PLCE1 gene (Phospholipase C epsilon 1). It plays a regulatory role in various cellular processes and may influence the expression of nearby genes, particularly those involved in cell signaling and developmental processes.

### 1. Associated Genes

While specific associations beyond PLCE1 may not be extensively documented, lncRNAs often interact with multiple gene pathways and can influence the expression of various genes. Some related genes that may exhibit functional associations with PLCE1-AS1 might include:

- **PLCE1**: As an antisense RNA, it likely has a direct regulatory effect on this gene.
- Other genes involved in similar signaling pathways, including but not limited to genes in the phospholipase family or those linked with phosphoinositide signaling.

### 2. Aging and Age-Related Diseases

Research on PLCE1-AS1 directly relating to aging or age-related diseases is limited but it has been noted in some studies that lncRNAs, including PLCE1-AS1, can be involved in the regulation of pathways affected during aging. Potential connections include:

- **Cellular Senescence**: Some lncRNAs play roles in the cellular senescence process, which is closely related to aging and age-associated pathologies.
- **Cancer**: PLCE1-AS1 may be implicated in cancer biology, as lncRNAs often have roles in tumorigenesis and could impact age-related cancer developments. Specifically, associations have been observed with certain cancers, but further research is necessary to clarify its function.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes directly associated with PLCE1-AS1. However, given the gene's potential role in cancer biology:

- **Anticancer Drugs**: Since lncRNAs are often potential biomarkers and therapeutic targets in cancer, drugs used in oncological settings may interact indirectly through pathways influenced by PLCE1-AS1.

### 4. Pathways and Biological Processes

PLCE1-AS1 is known to be involved in several biological processes and pathways:

- **Signal Transduction**: It may influence signaling pathways associated with phospholipase activity, particularly those mediated by phosphoinositides.
- **Developmental Processes**: Given its regulatory role, it could play a part in various developmental pathways and influences in cellular differentiation.
- **Cell Cycle Regulation**: lncRNAs often have regulatory roles affecting the cell cycle which could be relevant in contexts of cellular growth and proliferation.

### Conclusion

PLCE1-AS1 is a long non-coding RNA with essential roles linked primarily to gene regulation, especially concerning its nearby gene PLCE1. While more research is necessary to fully elucidate the gene's functions, its potential relevance to aging, cancer, and broader biological processes highlights its importance in the field of molecular biology. Further studies could provide deeper insights into its roles, especially in age-related contexts and therapeutic implications.