### MAN2C1 Gene

**Gene Symbol:** MAN2C1  
**Location:** Nucleoplasm  
**Predicted Function:** The MAN2C1 gene encodes a protein predicted to have alpha-mannosidase activity, facilitating the cleavage of specific mannose residues from oligosaccharides. This process plays a vital role in the oligosaccharide catabolic pathway, particularly in the degradation of N-glycoproteins.

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### 1. Associated Genes:
MAN2C1 may have functional associations with several other genes involved in glycan degradation and related pathways. While specific genes are not typically cataloged, manually curated biogenesis pathways suggest that this gene might interact with the following:

- **MAN1A1:** Involved in the processing of N-glycans.
- **MAN2A1:** Another alpha-mannosidase involved in oligosaccharide processing.
- **HRAS:** Gene implicated in signaling pathways possibly relevant to metabolism or glycan degradation.

Additionally, other genes in the glycosylation or protein degradation pathways may also show interaction or co-regulation.

### 2. Aging and Age-Related Diseases:
While direct associations of MAN2C1 with aging are scarce, alterations in glycosylation patterns are often observed in age-related diseases, including:

- **Neurodegenerative Diseases:** Abnormal glycan processing can contribute to amyloid plaque formation in diseases such as Alzheimer’s.
- **Diabetes:** Impaired glycoprotein metabolism may impact insulin signaling and contribute to complications of diabetes.
- **Cancer:** Changes in glycosylation can influence tumor progression and metastasis.

In general, disruptions in oligosaccharide catabolism might correlate with aging by affecting cellular signaling and metabolism.

### 3. Drug Interactions:
Currently, there is limited direct information on specific drugs that interact with the MAN2C1 gene or its encoded protein. However, drugs targeting glycosylation pathways or involved in metabolic syndromes might indirectly affect MAN2C1 function:

- **Enzyme Replacement Therapies:** In the case of lysosomal storage disorders related to glycan metabolism (e.g., mannosidosis).
- **Immunomodulators:** Some immunotherapeutic drugs target glycosylation patterns to enhance efficacy against cancer.

It’s worth noting that experimental compounds or inhibitors related to glycosylation may indirectly affect MAN2C1 activity.

### 4. Pathways and Biological Processes:
MAN2C1 is involved in several primary biological processes and pathways, including:

- **Oligosaccharide Metabolism:** Critical for proper glycoprotein degradation and recycling.
- **Glycoprotein Catabolism:** Participates in the lysosomal degradation of glycoproteins, facilitating the removal of misfolded proteins.
- **Protein Modifications:** Contributes to the post-translational modifications essential for protein functionality and stability.
- **Cellular Stress Responses:** May play a role in clearing protein aggregates during cellular stress conditions.

Understanding the full range of functions and interactions related to MAN2C1 is an ongoing field of research, and new discoveries may further elucidate its role in health and disease.