### SHROOM1 Gene Overview

**Gene Symbol:** SHROOM1  
**Protein Summary:** The SHROOM1 gene encodes a protein that is believed to play a significant role in the organization of microtubule arrays during cell elongation. It is crucial for proper cell shape and movement, which are essential processes during development and tissue morphogenesis.

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### 1. Associated Genes

The SHROOM1 gene is associated with several other genes, particularly those involved in cytoskeletal organization, cell signaling, and development. Some of the notable genes associated with SHROOM1 include:

- **ACTB** (Actin Beta): Involved in cell structure and motility.
- **RHOA** (Ras Homolog Family Member A): Plays a role in cell migration and cytoskeletal dynamics.
- **MYO9B** (Myosin IXB): Involved in actin filament organization and regulation.
- **TGFBR1** (Transforming Growth Factor Beta Receptor 1): Involved in TGF-beta signaling and various developmental processes.

### 2. Aging and Age-Related Diseases

While there is limited direct research linking SHROOM1 to aging, its role in cell morphogenesis suggests that it may contribute to age-related tissue remodeling and degeneration. Abnormalities in microtubule organization and cytoskeletal integrity have been linked to various age-related diseases, including neurodegenerative diseases. Impaired cell signaling and morphology can affect processes like wound healing and tissue regeneration, which tend to decline with age.

### 3. Drug Interactions

As of my last knowledge update in October 2023, there are limited direct interactions between SHROOM1 and specific drugs available in the literature. Though drugs that target pathways associated with cytoskeletal dynamics (e.g., microtubule-targeting agents like taxanes) may indirectly affect SHROOM1 function, direct pharmacological interactions have not been extensively characterized. More research is likely needed to identify any potential therapeutic agents that modulate SHROOM1 activity.

### 4. Pathways and Biological Processes

SHROOM1 is involved in several pathways and biological processes, including:

- **Cytoskeleton Organization:** SHROOM1 contributes to microtubule organization and stability, which is essential for cell shape.
- **Cell Morphogenesis:** It plays a key role in processes that require cells to change shape, especially during development.
- **Cell Division and Migration:** By influencing cytoskeletal dynamics, SHROOM1 is critical for normal cell division and migration.
- **Wnt Signaling Pathway:** SHROOM1 is believed to have a role in the Wnt signaling pathway, which is important for cell fate determination and coordination of morphology during embryogenesis.

### Conclusion

SHROOM1 is a critical gene involved in maintaining cellular structure and function, particularly through its role in microtubule dynamics. While its direct involvement in aging and age-related diseases remains an area for further exploration, its impact on cellular processes highlights its importance in development and potential implications in tissue homeostasis over a lifetime. Further studies are warranted to elucidate the interactions and pathways pertinent to SHROOM1 in both health and disease contexts.