### FGFBP3 Gene Overview

**Gene Symbol:** FGFBP3  
**Location:** Extracellular region  
**Function:** FGFBP3 (Fibroblast growth factor-binding protein 3) is a heparin-binding protein known for its role in binding fibroblast growth factor 2 (FGF2). It prevents FGF2 from binding to heparin, which likely inhibits its immobilization on the extracellular matrix glycosaminoglycans. This action allows for the release of FGF2 and subsequently activates fibroblast growth factor receptor (FGFR) signaling pathways, contributing to processes such as increased vascular permeability.

### 1. Associated Genes

The FGFBP3 gene is mainly associated with other genes involved in fibroblast growth factor signaling and pathology related to vascularity and permeability. Although specific gene associations are not highlighted in the provided summaries, it is known to interact with several genes in the FGF signaling pathway, including but not limited to:
- **FGF2 (Fibroblast Growth Factor 2):** As a direct binding partner.
- **FGFR1, FGFR2, FGFR3, FGFR4:** Members of the fibroblast growth factor receptor family involved in signaling pathways influenced by FGF2.

### 2. Aging and Age-related Diseases

FGFBP3 has been implicated in various biological processes relevant to aging and age-related diseases. While specific studies directly correlating FGFBP3 with aging are limited, its role in vascular permeability and FGF signaling can have implications in age-associated conditions such as:
- **Atherosclerosis:** Impaired FGF signaling could impact vascular health.
- **Wound healing:** FGF signaling plays a key role in tissue repair, which can decline with age.
- **Cancer:** Abnormal FGF signaling is often associated with tumor development and metastasis, which may relate to age-related increases in cancer risk.

### 3. Drug Interactions

Currently, there are no specific drugs listed that are directly known to interact with FGFBP3 in a pharmacological context. However, drugs that influence the fibroblast growth factor pathways or vascular permeability might indirectly affect its activity. This may include:
- **FGF inhibitors:** Such as those targeting FGFRs.
- **Anticoagulants or anti-inflammatory drugs:** That may modulate vascular permeability processes.

### 4. Pathways and Biological Processes

FGFBP3 is involved in several critical biological processes and pathways:
- **Positive Regulation of FGFR Signaling Pathway:** Enhancing fibroblast growth factor receptor activity.
- **Vascular Permeability Regulation:** Modulating the movement of fluids and solutes across blood vessels.
- **Cell Migration and Proliferation:** As part of wound healing and tissue repair associated with FGF signaling.
- **Angiogenesis:** Facilitating new blood vessel formation which is often regulated by FGF signaling.

### Summary

FGFBP3 is an essential player in the regulation of FGF signaling pathways and vascular health. Given its potential role in various biological processes and interactions with other genes, research continues into its implications for aging, disease states, and the development of therapeutic interventions.