The CDCA3 gene (Cell Division Cycle Associated 3) is an important player in the regulation of the cell cycle, particularly during the transition from the G2 phase to mitosis. Below are additional details regarding the gene, including its associations, involvement in aging and diseases, interactions with drugs, and associated biological pathways:

### 1. Associated Genes
While the summaries provided do not list specific genes directly associated with CDCA3, several genes involved in cell cycle regulation may be highlighted in relation to its function:

- **WEE1**: As mentioned, CDCA3 mediates the ubiquitination and degradation of WEE1 kinase, a crucial regulator of the G2/M checkpoint.
- **CDK1**: Cyclin-dependent kinase 1 is a primary controller of the cell cycle, particularly at the G2/M checkpoint.
- **Cyclins**: Cyclins, especially Cyclin B, may also interact with CDCA3 in the context of cell cycle progression.
- **Anaphase Promoting Complex/Cyclosome (APC/C)**: This complex contributes to ubiquitination processes during the mitotic phase.

### 2. Aging and Age-Related Diseases
While specific direct associations between CDCA3 and aging are not extensively characterized, its role in cell division implicates it in processes that could affect aging and age-related diseases:

- **Tumorigenesis**: Dysregulation of CDCA3 may lead to aberrant cell cycle progression, potentially resulting in uncontrolled cell growth and cancer. Cancer risk tends to increase with aging.
- **Cellular Senescence**: Alterations in cell cycle regulation and protein degradation mechanisms can impact cellular senescence, thereby influencing aging processes.

### 3. Drug Interactions
Currently, there are no specific drugs directly targeting CDCA3 reported in literature. However, drugs that affect the cell cycle and are used in cancer therapy may indirectly impact pathways associated with CDCA3:

- **Anticancer drugs**: Many chemotherapeutic agents target mitosis (e.g., paclitaxel, vincristine) and may affect pathways involving CDCA3 due to its role in regulating cell division.
- **CDK Inhibitors**: Drugs like palbociclib (a CDK4/6 inhibitor) indirectly relate to CDCA3's functions as they alter cell cycle progression.

### 4. Pathways and Biological Processes
CDCA3 is involved in several important biological processes and pathways:

- **Cell Cycle**: CDCA3 is critical for the progression of the cell cycle, particularly in the transition from G2 to M phase.
- **Ubiquitin-Mediated Proteolysis**: As it participates in E3 ligase complexes, CDCA3 plays a role in the ubiquitination of target proteins, especially for the degradation of WEE1 during the G2/M transition.
- **Mitotic Regulation**: It is linked to the regulation and timing of mitosis, ensuring that cells correctly transition into the division phase.

CDCA3 thus emerges as an essential player in cell cycle regulation, with implications in cancer biology and potentially influencing aging mechanisms, although more research is required to elucidate its comprehensive role in these contexts.