### Overview of the PPP4R3C Gene

**Gene Symbol:** PPP4R3C  
**Protein Summary:** The PPP4R3C gene encodes a member of the protein phosphatase 4 regulatory subunit 3 family, which is part of the SMEK family. This protein plays a critical role in the regulation of protein phosphatase 4 (PP4), which is involved in various cellular functions including the cell cycle, DNA damage response, and controlling apoptosis.

### 1. Associated Genes
While specific gene associations may vary between studies and databases, PPP4R3C has been implicated in interactions with:

- **PPP4C**: the catalytic subunit of protein phosphatase 4, which PPP4R3C is known to regulate.
- **SMEK1/SMEK2**: as additional members of the SMEK family that may have overlapping or related functions.
- **ANXA2**: associated with PP4 complex interactions.
  
### 2. Aging and Age-Related Diseases
Research indicates that PPP4R3C may play a role in cellular processes affecting aging, such as:

- **DNA Damage Response**: It is important for the maintenance of genomic stability, which can influence aging.
- **Regulation of Apoptosis**: Perturbations in apoptotic pathways are commonly noted in age-related diseases, including neurodegeneration and cancer.
- **Cellular Senescence**: Emerging data suggest that proteins involved in phosphatase activity could influence cellular senescence, thereby impacting aging processes.

### 3. Drug Interactions
While there may not be specific drugs directly targeting PPP4R3C, it is known that:

- **Cancer therapies**: Given its role in cell cycle regulation and apoptosis, PPP4R3C may interact with drugs that affect these pathways, such as kinase inhibitors and chemotherapeutic agents. 
- **Phosphatase inhibitors**: General phosphatase inhibitors may indirectly influence PPP4R3C activity.

Note: Specific drugs for PPP4R3C are not typically highlighted in the literature, and the exploration of small molecule modulators is ongoing.

### 4. Pathways and Biological Processes
PPP4R3C is involved in multiple key pathways and biological processes, such as:

- **Cell Cycle Regulation**: Facilitating control over various phases of the cell cycle.
- **DNA Damage Repair**: Critical in sensing and repairing DNA lesions, thus maintaining genomic integrity.
- **Apoptosis**: Regulating programmed cell death, which is crucial in development and disease prevention.
- **Gene Expression Regulation**: Involved in the dephosphorylation processes that affect transcription factors and gene expression.

### Conclusion
The PPP4R3C gene and its associated protein are crucial for several biological functions related to cell regulation and maintenance. Emerging studies may further elucidate its roles in aging and disease, highlighting its potential as a therapeutic target in Pathologies linked with deregulated cell cycle dynamics and DNA repair mechanisms.