### PRICKLE2-AS3 Gene Overview

**Gene Symbol:** PRICKLE2-AS3  
**Type:** Long Non-Coding RNA (lncRNA)  

The PRICKLE2-AS3 gene is associated with various regulatory functions in gene expression and may be involved in biological processes that contribute to cellular function and development.

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### 1. Associated Genes

While the NCBI and UniProt summaries provide essential insights into PRICKLE2-AS3, it's crucial to explore related genes. PRICKLE2-AS3 is associated with:

- **PRICKLE2:** A protein-coding gene implicated in the planar cell polarity pathway and development, which plays a role in neural and cardiac development.
- **Other members of the Prickle family:** Such as PRICKLE1 and PRICKLE3, these genes also participate in cellular polarity and signaling pathways.
- **Wnt signaling pathway genes:** Genes associated with this pathway may intersect with PRICKLE2-AS3 function, enhancing the understanding of its role in developmental processes and potential disease implications.
- **CROSS-SPECIES ASSOCIATIONS:** PRICKLE2-AS3 may also be associated with non-coding RNAs or regulatory elements in other species relevant for comparative genomics studies.

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### 2. Aging and Age-Related Diseases

Research exploring the link between PRICKLE2-AS3 and aging or age-related diseases is limited. However, some potential associations include:

- **Developmental Implications:** Given the role of PRICKLE-family genes in development, dysregulation of PRICKLE2-AS3 may contribute to age-related decline in tissue regeneration or in neurodegenerative diseases.
- **Cancer Associations:** Long non-coding RNAs, including those in the Prickle family, have been implicated in the regulation of tumorigenesis, suggesting that PRICKLE2-AS3 may be indirectly involved in age-related cancers.
- **Neurodegeneration:** Genetic dysregulation in pathways associated with PRICKLE2 has been linked to disorders like Alzheimer's disease, highlighting potential pathways connecting PRICKLE2-AS3 with age-related neurodegenerative processes.

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### 3. Drug Interactions

As of the last updates, specific drugs or drug classes directly targeting PRICKLE2-AS3 have not been established in the scientific literature. However, research on lncRNA functions is ongoing, and their modulation could influence:

- **Targeting pathways influenced by PRICKLE2:** Drugs affecting Wnt signaling or gene expression modulators may indirectly interact with the pathways associated with PRICKLE2-AS3.
- **Potential future classifications can include:** Antisense oligonucleotides or small molecule inhibitors that might target the regulatory pathways or molecular interactions involving PRICKLE2-AS3.

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### 4. Pathways and Biological Processes

PRICKLE2-AS3 may be involved in:

- **Planar Cell Polarity:** This pathway is crucial for developmental processes, particularly in the orientation of cells within the tissue.
- **Neural Development:** Given its association with the PRICKLE gene family, this lncRNA may play a role in neural patterning and function.
- **Wnt Signaling Pathway:** This crucial pathway for cell-to-cell communication during embryonic development may be influenced by the activity of PRICKLE2-AS3.
- **Cell Growth and Differentiation:** Contributions to cellular processes such as proliferation, differentiation, and apoptosis could also be mediated through regulatory interactions.

### Summary

The PRICKLE2-AS3 gene represents a compelling area of study in the field of genetics and molecular biology. Ongoing research may provide further insights into its regulatory roles, clinical relevance in aging and disease, and potential therapeutic interactions. Close examination of the associated genes, biological pathways, and possible connections to pharmacological agents will enrich our understanding of this lncRNA's significance in health and disease.