The PHKBP1 gene, also known as "PH domain and leucine-rich repeat protein PhkBp1," is a protein-coding gene that has garnered attention for its potential roles in various biological processes.

### 1. Associated Genes
While the NCBI and UniProt summaries may focus on PHKBP1, studies involving co-expression or protein interactions may indicate relationships with other genes involved in similar pathways or functions. Some genes that have been associated with PHKBP1 in various contexts include:
- **PIK3CG**: Phosphatidylinositol 3-kinase, gamma variant.
- **AKT1**: Thymoma viral proto-oncogene 1.
- **RAPGEF2**: Rap guanine nucleotide exchange factor 2.
- **FBXW7**: F-box and WD repeat domain containing 7, implicated in ubiquitination and degradation processes.

### 2. Aging and Age-Related Diseases
Current research has begun to delve into the implications of PHKBP1 in aging and age-related diseases, though specific studies might be limited. Some points to consider may include:
- PHKBP1's involvement in cellular signaling and metabolic processes could suggest a role in age-related cellular dysfunction.
- Alterations in phosphoinositide signaling or related pathways in which PHKBP1 participates may be linked to age-related pathologies such as cancer, neurodegeneration, or metabolic syndromes.
- Certain translational studies may highlight variations in the expression levels of PHKBP1 in aged tissues compared to younger controls.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly interact with PHKBP1 may not be well-characterized in the literature. However, considering its involvement in signaling pathways, gene functions, and potential roles in metabolism:
- **PI3K Inhibitors**: Since PHKBP1 may interact with PIK3CG and the AKT signaling pathway, pharmacological agents targeting this pathway could indirectly be relevant.
- **mTOR Inhibitors**: Given the association of phosphoinositide signaling with mTOR pathways, drugs affecting mTOR signaling may also be of interest.

### 4. Pathways and Biological Processes
PHKBP1 is involved in several critical biological processes, including but not limited to:
- **Phosphoinositide Signaling**: Acts in pathways that modulate cellular responses to growth factors and environmental stimuli via phosphoinositides.
- **Cellular Growth and Proliferation**: Trends toward mediating signals that affect cell division, survival, and growth.
- **Regulation of Metabolism**: Potential involvement in pathways that regulate lipid metabolism and energy homeostasis.

Research continues to elucidate the full scope of functions and interactions of PHKBP1, particularly in the context of its biological significance across various health domains. Further studies are necessary to establish more details about its involvement in aging and potential therapeutic targets for age-related diseases.