### Gene Overview: GAS2L3

**Gene Symbol**: GAS2L3  
**Function**: GAS2L3 encodes a cytoskeletal linker protein that exhibits actin and microtubule binding activity and is important in the organization of the cytoskeleton. It is implicated in promoting and stabilizing the formation of the actin and microtubule networks, which are crucial for various cellular processes including cell shape, motility, and division.

### 1. Associated Genes
GAS2L3 is part of the GAS2 family of genes, which includes:
- **GAS2**: Another member of the GAS2 family, involved in cytoskeletal regulation.
- **GAS2L1**: A gene that shares some functional properties with GAS2L3.
- **GAS2L2**: Also a member of the GAS2 family, associated with similar cellular functions.
Additionally, GAS2L3 may interact with other genes in the cytoskeletal regulatory network, specifically those involved in actin dynamics (e.g. **CFL1**, **ACTB**) and microtubule stability (e.g. **MAPT**, **TUBB**).

### 2. Aging and Age-related Diseases
Currently, specific studies linking GAS2L3 directly to aging or age-related diseases remain limited. However, given its role in cytoskeletal organization, it may play a part in cellular processes that are affected by aging, such as cellular senescence and the maintenance of cell structure. Alterations in the cytoskeletal components are often observed in aging tissues and age-related diseases, including neurodegenerative disorders like Alzheimer's disease, where microtubule dysfunction is a prominent feature. Further studies might elucidate a more direct connection between GAS2L3 and specific aging processes or age-related pathological states.

### 3. Drug Interactions
As of the latest updates, there are currently no specific drugs or drug classes that have been definitively associated with GAS2L3. However, understanding its role in actin and microtubule dynamics suggests potential interactions with drugs that target these structures. For example:
- **Colchicine**: Inhibits microtubule polymerization and could indirectly affect GAS2L3 function through the disruption of microtubule-associated processes.
- **Cytochalasins**: Actin-disrupting agents that may influence the functions of proteins like GAS2L3.

### 4. Pathways and Biological Processes
GAS2L3 is involved in several significant biological processes, including but not limited to:
- **Actin Cytoskeleton Organization**: It supports the assembly and maintenance of the actin filaments.
- **Microtubule Cytoskeleton Organization**: Facilitates the stabilization and organization of microtubules, crucial for cellular shape and intracellular transport.
- **Cell Adhesion**: By stabilizing cytoskeletal networks, GAS2L3 may influence how cells adhere to one another and to extracellular matrices.
- **Cell Migration and Division**: Given its role in cytoskeletal dynamics, it is likely important in processes that involve cell movement and division, which are vital for development and tissue repair.

In conclusion, GAS2L3 serves a critical role in cytoskeletal integrity and organization, influencing various cellular processes. While its specific associations with aging and therapeutic implications remain to be explored further, its functional architecture suggests potential areas of significance in both developmental biology and age-related studies.