### LRRC49 Gene Overview

**Gene Symbol**: LRRC49  
**Aliases**: (if applicable) - Additional aliases were not provided in the summaries.

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### 1. Associated Genes 
While specific gene associations can vary, LRRC49 is believed to be involved with several related genes known to participate in ciliary and flagellar function, outer dynein arm assembly, and tubulin modification processes. Related genes that may interact with LRRC49 include:
- **TUBB** (Tubulin Beta Class I)
- **DYN** (Dynein Cytoplasmic 1 Heavy Chain 1)
- **TTC** (Tetratricopeptide Repeat Domain)
- **GAPDH** (Glyceraldehyde-3-Phosphate Dehydrogenase) – While not directly related to motility, involved in metabolic processes important for cellular function.

Further exploration of protein-protein interactions through databases like STRING or BioGRID may yield additional potential interactions that are not captured in simple associations.

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### 2. Aging and Age-Related Diseases
Current literature indicates that cilia and flagella function is critical for various physiological processes, and impaired cilial function has been linked to age-related diseases. Although there could be avenues of research connecting LRRC49 to aging or related pathologies (such as neurodegeneration, kidney disease, and certain forms of ciliopathy), specific associations have not been extensively characterized in the literature as of the last available data. Any indirect findings suggest that the dysregulation of ciliary proteins may lead to reduced cellular signaling efficiency and contribute to senescence. Further studies are needed to corroborate any direct effects of LRRC49 on aging mechanisms.

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### 3. Drug Interactions
Currently, there is insufficient detailed information directly linking specific drugs or drug classes with interactions with the LRRC49 gene. However, since LRRC49 is implicated in ciliary function, it would be prudent to consider drugs aimed at treating ciliopathies, as they may indirectly interact with the pathways involving LRRC49. The pharmacological modulation of ciliary functions might involve:
- **Antioxidants**: As oxidative stress can affect ciliary function.
- **Microtubule Stabilizers** (e.g., Taxanes): Could affect structures associated with the action of genes like LRRC49.

Ongoing research is required to fully elucidate drug interactions with this gene.

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### 4. Pathways and Biological Processes
LRRC49 is implicated in several biological pathways, including:
- **Ciliary Assembly**: Integral to the structure and function of motile cilia and flagella.
- **Dynein Complex Assembly**: Involved specifically in the outer dynein arm assembly which is crucial for ciliary movement.
- **Tubulin Polyglutamylation**: Participates in the tubulin polyglutamylase complex, which is vital for the post-translational modifications of tubulin proteins that are essential for cytoskeletal integrity and function.

Moreover, the LRRC49 gene may be associated with:
- **Intraflagellar Transport**: Supporting the transport processes necessary for constructing and maintaining cilia and flagella.
- **Ciliopathies**: Given its involvement in structural components of cilia, mutations or dysregulations could have implications in various ciliopathies.

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### Conclusion
In summary, the LRRC49 gene is a critical component in cilia and flagella motility, with its functions spanning multiple biological processes and potential interactions with other genes. The nexus between LRRC49, aging, and drug interactions remains an area worthy of further exploration, as it may reveal targeted therapeutic opportunities for diseases associated with ciliary dysfunction.