**Gene Overview: TOM1L1**

The TOM1L1 gene encodes a probable adapter protein that plays a significant role in various cellular signaling pathways. It is primarily known for its activities related to clathrin binding and protein kinase binding, indicating its involvement in endocytosis and intracellular signaling processes.

### Additional Information:

1. **Associated Genes:**
   While the summaries provided do not mention specific genes associated with TOM1L1, in the context of functional interactions, TOM1L1 may interact with proteins involved in signal transduction pathways, such as:
   - **FYN**: A member of the Src family of protein tyrosine kinases that it may help activate.
   - **Other signaling proteins** bearing SH2 or SH3 domains, which often include:
     - GRB2 (Growth factor receptor-bound protein 2)
     - SOS1 (Son of sevenless homolog 1)
     - Other Src family kinases
   The specific associations may depend on the study context and cellular conditions.

2. **Aging and Age-Related Diseases:**
   As of October 2023, specific studies directly linking TOM1L1 to aging processes or age-related diseases are limited. However, due to its role in signal transduction and mitotic regulation, it might play an indirect role in processes associated with cellular aging, such as:
   - Regulation of apoptosis, which can have implications in cancer development.
   - Influence on cellular proliferation and senescence, processes that are critically important in aging.
   Exploring genomic databases and recent literature for possible implications in conditions like cancer or neurodegenerative diseases could yield more information.

3. **Drug Interactions:**
   Currently, direct drug interactions specific to TOM1L1 are not well-documented in the literature or databases. However, since it is involved in signal transduction pathways, it may be affected by drugs targeting kinases or signaling pathways:
   - **Kinase Inhibitors**: Drugs that inhibit Src family kinases or related pathways might indirectly influence TOM1L1's function through alteration in kinase signaling.
   - General antineoplastic agents that affect signaling pathways may also have upstream effects involving TOM1L1.

4. **Pathways and Biological Processes:**
   TOM1L1 is implicated in several biological processes, including but not limited to:
   - **Signal Transduction**: It acts as an adapter protein facilitating interactions in signaling cascades.
   - **Mitotic Nuclear Division**: TOM1L1 is involved in the negative regulation of this process.
   - **Protein Phosphorylation**: It positively regulates pathways involved in protein phosphorylation, a critical mechanism for cellular signaling.
   - **Endocytosis**: The clathrin-binding activity suggests its involvement in endocytotic processes, facilitating internalization of receptors and other proteins.
   - **Cellular Response to Growth Factors**: As it interacts with signaling proteins, it may play a role in the cellular response to stimuli.

In summary, while some functional roles and interactions of TOM1L1 are clear, the gene's specifics related to aging, drug interactions, and pathway involvement warrant further investigation, especially considering ongoing research and evolving knowledge in genetics and molecular biology.