### FBXO45 Gene Overview

**Gene Symbol:** FBXO45  
**Location:** The FBXO45 gene is located on chromosome 13 in humans.

**Protein Summary:** 
FBXO45 is a member of the F-box protein family, which is involved in the ubiquitin-proteasome pathway, specifically as a component of E3 ubiquitin ligase complexes. It recognizes specific substrates for ubiquitination, a post-translational modification that typically targets proteins for degradation. FBXO45 is particularly noted for its role in the nervous system, including:

- Neuromuscular synaptogenesis
- Axon pathfinding
- Neuronal migration
- Regulation of neurotransmission

FBXO45 interacts with proteins involved in cell signaling and cellular structure, including N-cadherin (CDH2), TP73, NMNAT2, and FBXW7, impacting functions ranging from neuronal stability to cell cycle regulation.

### 1. Associated Genes
FBXO45 interacts and is associated with several other genes, which have not been explicitly mentioned in the provided summaries, including:

- **N-Cadherin (CDH2):** For neuronal migration and synaptogenesis.
- **TP73:** Targeted for ubiquitination and degradation.
- **NMNAT2:** Involved in axon maintenance and stability.
- **FBXW7:** An important regulator in the cell cycle, particularly during mitosis.
- **IFNLR1:** Associated with immune response post-influenza infection.

### 2. Aging and Age-Related Diseases
- **Neurodegenerative Diseases:** Given its role in neuronal migration and synaptic activity, dysregulation of FBXO45 could be implicated in neurodegenerative conditions such as Alzheimer's disease.
- **Cancer:** Alterations in FBXO45's function may contribute to oncogenesis by affecting the stability of tumor suppressors like FBXW7.
- **Muscular Disorders:** Due to its participation in neuromuscular synaptogenesis, FBXO45 might be involved in age-related muscular degeneration and disorders.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes widely recognized to directly target FBXO45. However, since FBXO45 is involved in the ubiquitin-proteasome pathway, drugs that regulate proteasomal functions, such as proteasome inhibitors (e.g., bortezomib, carfilzomib), might indirectly affect its activity.

### 4. Pathways and Biological Processes
FBXO45 is involved in several key biological pathways:

- **Ubiquitin-Mediated Protein Catabolism:** Plays a central role in the degradation of proteins through the proteasome.
- **Cell Cycle Regulation:** Particularly during mitotic phases, contributing to processes like mitotic slippage.
- **Neuronal Development and Synaptic Function:** Implicated in neurogenesis and maintaining synaptic integrity.
- **Immune Response:** Involved in the regulation of the antiviral response to influenza by mediating the degradation of IFNLR1.

**Additional Pathways:**

- **N-Cadherin Signaling Pathway:** Affecting neural crest cell migration and synaptic formation.
- **TP73 Pathway:** Modulating cell death and survival mechanisms.

### Conclusion
The FBXO45 gene plays a multifaceted role in neuronal functions and cell cycle regulation, with implications in neurodevelopmental processes and potential associations with aging and diseases. This underscores the importance of ongoing research to elucidate its functions and interactions in greater detail within various biological contexts.