### TMEM95 Gene Overview

**Gene Symbol:** TMEM95  
**Location:** Integral membrane protein that is thought to play a crucial role in reproduction, particularly in the process of fertilization. It is located in the sperm plasma membrane and is specifically active in the acrosomal membrane.

### 1. Associated Genes
While the primary function of TMEM95 is related to sperm-egg membrane fusion, there are no direct or well-documented associations with specific other genes widely recognized in the literature. However, genes involved in similar reproductive processes or sperm functionality, such as **SPACA1, IZUMO1**, and **TNP1**, may have functional overlaps or regulatory interactions during fertilization. Further studies are necessary to delineate specific interactions.

### 2. Aging and Age-related Diseases
Currently, there are no comprehensive studies explicitly linking TMEM95 to aging or age-related diseases. Its involvement in reproductive processes, specifically in male fertility, suggests that anomalies in its function could indirectly affect fertility as individuals age. Infertility is often associated with aging, particularly in males, due to factors affecting sperm quality and function. More research is needed to explore any direct connections of TMEM95 with aging processes or age-related reproductive decline.

### 3. Drug Interactions
As of the latest information, there are no specific drugs or drug classes identified that directly interact with the TMEM95 gene product. Research into reproductive health and fertility treatments may lead to implications for TMEM95, but further evidence is required to establish any formal drug-gene interactions.

### 4. Pathways and Biological Processes
TMEM95 is primarily involved in the following biological processes:
- **Fertilization**: It plays a pivotal role in the fusion of sperm with the egg plasma membrane, essential for the successful completion of fertilization.
- **Membrane dynamics**: Its localization and function suggest involvement in membrane fusion events which are critical during acrosome reaction and sperm-egg interactions.

### Conclusion
TMEM95 is an important gene in the context of male fertility, specifically in the process of sperm-egg fusion. While current knowledge highlights its role in reproductive biology, there is an opportunity for future research to uncover more extensive interactions, potential implications in aging or reproductive decline, and any relevant therapeutic targets or interactions with drugs.