### CTNNAL1 Gene Overview

**Gene Symbol:** CTNNAL1  
**Gene Location:** Cytosol  
**Predicted Functions:** 
- Actin filament binding activity 
- Cadherin binding activity  
**Biological Role:** CTNNAL1 is believed to play a significant role in modulating Rho GTPase signaling pathways, particularly via acting as a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

### 1. Associated Genes
CTNNAL1 has been found to relate to various other genes involved in similar pathways or functions. Some of the important associated genes include:
- **ARHGEF1** (Lbc): The guanine nucleotide exchange factor that interacts directly with CTNNAL1 in Rho signaling.
- **CTNNA1**: Encodes alpha-catenin, a protein that may interact with CTNNAL1 in cell adhesion and cytoskeletal arrangement.
- **RhoA, Rac1, and Cdc42**: Members of the Rho family of GTPases that are integral to cell signaling pathways that regulate various cellular functions.

### 2. Aging and Age-Related Diseases
While specific studies directly linking CTNNAL1 to aging or age-related diseases are limited, its influence on Rho signaling pathways suggests potential connections. Rho GTPases are known to play roles in:
- Cellular senescence
- Tumorigenesis
- Cardiovascular diseases

Given the impact of these pathways on cellular functions like proliferation and apoptosis, abnormalities in CTNNAL1 expression or function could be implicated in age-related decline or disease.

### 3. Drug Interactions
As CTNNAL1 is primarily associated with regulating signaling pathways rather than being a direct drug target, there may not be specific drugs that target CTNNAL1 directly. However, drugs that modulate the Rho signaling pathways, such as:
- **Rho Kinase inhibitors (e.g., Y-27632, Fasudil)**: These affect Rho GTPase activity and may indirectly influence CTNNAL1 function.
  
Research is ongoing into more specific interactions, particularly involving therapeutic compounds that impact cytoskeletal arrangements and signaling.

### 4. Pathways and Biological Processes
CTNNAL1 is involved in several key biological pathways and processes:
- **Rho protein signal transduction**: It modulates signals carried by Rho GTPases, which are central to many cellular processes.
- **Cell adhesion**: By interacting with cadherins and beta-catenins, CTNNAL1 plays a role in maintaining cellular structure and integrity.
- **Actin cytoskeleton organization**: It influences the dynamics and organization of the actin filament structure, essential for cell shape and mobility.
- **Regulation of gene expression**: Indirectly through its role in shaping cellular signaling environments.

Further research could unveil additional details regarding its involvement in specific cellular processes, disease mechanisms, and potential therapeutic targets.