### GABRG3-AS1 Gene Overview

**Gene Symbol:** GABRG3-AS1  
**Type:** Antisense RNA  

The GABRG3-AS1 gene is an antisense RNA gene that is located adjacent to the GABRG3 gene, which encodes a subunit of the gamma-aminobutyric acid (GABA) receptor. The GABA receptor is critical in neurotransmission and plays a significant role in modulating neuronal excitability and inhibition within the central nervous system.

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### 1. Associated Genes

GABRG3-AS1 is primarily associated with the following gene:
- **GABRG3:** This is the primary gene that it is associated with, as GABRG3-AS1 is positioned in an antisense orientation to GABRG3. Additionally, it has been suggested that the activity of GABRG3-AS1 may influence the expression of GABRG3.

While specific associations with other genes may not be well-characterized, regulatory and expression studies often examine lnc RNA (long non-coding RNAs) like GABRG3-AS1 concerning various genes within the GABAergic system and neurodevelopmental disorders.

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### 2. Aging or Age-Related Diseases

There is limited direct evidence linking GABRG3-AS1 explicitly with aging or age-related diseases in the literature. However, since it is involved in the GABA signaling pathway, it may have indirect implications for age-related neurological conditions, such as:
- **Alzheimer’s Disease:** Changes in GABAergic signaling have been associated with cognitive decline.
- **Neurodegenerative Diseases:** Alterations in neurotransmitter systems with age may impact diseases such as Parkinson's disease.

Further research would be requisite to elucidate direct roles of GABRG3-AS1 in aging and related pathologies.

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### 3. Drug or Drug Classes

Currently, there are no specific drugs or drug classes that directly target GABRG3-AS1. However, since it is associated with the GABRG3 gene, which encodes a component of the GABA receptors, any medications that interact with the GABAergic system may indirectly relate to the function of GABRG3-AS1. This includes:
- **Benzodiazepines:** Drugs used to enhance the effect of GABA at the GABA-A receptor.
- **Barbiturates:** Another class of drugs that act as CNS depressants via GABA modulation.
- **Anti-seizure medications:** Such as valproate and others that modify GABA levels or receptor activity.

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### 4. Pathways and Biological Processes

GABRG3-AS1 is involved in several biological processes, primarily through its regulatory role on GABRG3. It may influence:
- **Neurotransmission:** By modulating gene expression related to GABA receptors.
- **Neurological function:** As GABA is crucial for inhibitory neurotransmission, the GABRG3-AS1 is thought to play a role in aspects such as anxiety, epilepsy, and overall neural circuit function.
- **Stress response and neurodevelopment:** It may be implicated in developmental processes of the nervous system and in responses to various stressors.

While the precise pathways involving GABRG3-AS1 directly are still under exploration, it can be positioned within the broader context of GABA signaling pathways and neuronal communication processes.

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In summary, GABRG3-AS1 is an antisense RNA gene affiliated with the GABRG3 gene, influencing GABA receptor dynamics with potential implications in neurological function and possibly in age-related diseases and therapeutic contexts that involve the GABAergic system. Further studies are required to determine its functionalities and relevance comprehensively.