The **SLC39A14** gene encodes a member of the solute carrier family that primarily functions as a divalent metal transporter. The following additions provide a comprehensive overview of the gene beyond the provided summaries:

### 1. Associated Genes
While the summaries mention its role with various metal ion transport processes, specific genes directly associated with SLC39A14 include:
- **SLC39A8** and **SLC39A7**: These members of the SLC39 family are also involved in metal transport, potentially showing overlapping functions with SLC39A14.
- **FPN1 (SLC40A1)**: Known for iron export, FPN1 may interact indirectly with SLC39A14 in regulating iron homeostasis in the body.
- **TF (Transferrin)**: As SLC39A14 can import nontransferrin-bound iron, there is an interaction within iron metabolism pathways.
- **CBD (Cytokine Binding Domain Integrated Pathways)**: Various cytokines regulated by macrophages, such as IL-6 and TNF-alpha, can be morphologically linked to immune signaling pathways influenced by the transport regulation by SLC39A14.

### 2. Aging and Age-Related Diseases
SLC39A14 has been investigated within the context of:
- **Neurodegeneration**: Mutations in SLC39A14 are linked to neurodegenerative disorders like neurodegeneration with brain iron accumulation (NBIA), which can manifest symptoms reminiscent of normal aging processes in the nervous system.
- **Parkinsonism-Dystonia**: Early-onset forms of these diseases, potentially presenting additional risks as aging progresses, suggest a disruption in manganese and iron homeostasis, which are critical for neurological health.
- **Oxidative Stress**: Dysregulation of metal ions, particularly when involving their transport mechanisms, can lead to increased oxidative stress over time, potentially contributing to aging-related cellular dysfunctions.

### 3. Drug Interactions
While there are currently no specific FDA-approved drugs that directly target SLC39A14, here are the categories of compounds observed to interact:
- **Metal Chelators**: Drugs designed to bind metal ions (e.g., deferoxamine, EDTA) may indirectly affect the functioning of SLC39A14 by influencing the bioavailability of manganese and iron.
- **Zinc Supplements**: Over-the-counter zinc supplements could theoretically alter the dynamics of cellular zinc levels and the functioning of SLC39A14, emphasizing its role in maintaining zinc homeostasis.

### 4. Pathways and Biological Processes
SLC39A14 is involved in several critical biological processes and pathways, including:
- **Metal Ion Transport**: The primary function as a transporter of divalent metal ions (manganese, zinc, and iron) is central to various metabolic pathways.
- **Innate Immunity Pathways**: By modulating cytokine release from macrophages, it plays a role in innate immune responses, critical for combating infections and inflammatory responses.
- **Regulation of G Protein-Coupled Receptor Signaling**: Via its action on zinc-dependent pathways which influence processes such as gluconeogenesis.
- **Endocrine Functions**: Involved in the modulation of insulin receptor signaling and consequently glucose metabolism, linking metal ion transport with metabolic disorders.
- **Cellular Stress Responses**: Plays a part in how cells adapt to endoplasmic reticulum stress, a contributor to various age-related diseases.

### Summary
SLC39A14 plays a vital role in divalent metal ion transport, with implications in metal ion homeostasis, immunity, and age-related diseases like neurodegeneration. The interplay between this gene and other transporters, metal chelators, and metabolic processes underscores its importance in both health and disease states. Ongoing research continues to elucidate its multifaceted roles across biological systems and their relevance to aging.