### FBXO28 Gene Overview

**Gene Symbol**: FBXO28  
**Gene Description**: FBXO28 (F-box protein 28) is a member of the F-box protein family, which is characterized by the presence of an F-box motif. F-box proteins function in ubiquitination and regulate the degradation of specific proteins by the proteasome. FBXO28 is believed to primarily recognize and bind certain phosphorylated proteins, promoting their ubiquitination and subsequent degradation, thereby playing a crucial role in cellular signaling and homeostasis.

### 1. Associated Genes
While specific gene associations beyond the primary function of FBXO28 might not be extensively documented, it may interact with other components in the ubiquitin-proteasome pathway or target proteins. Examples may include:

- **Cyclin D1 (CCND1)**: Known to be regulated by F-box proteins, possibly involving FBXO28.
- **p53 (TP53)**: As a protein involved in cell cycle regulation, there may be indirect associations.
- **REST (RE1-silencing transcription factor)**: Regulates various F-box proteins including FBXO28.

### 2. Aging and Age-related Diseases
The role of FBXO28 in aging and age-related diseases is not extensively characterized. However, the ubiquitin-proteasome system is critical for maintaining cellular homeostasis and protein quality control, which have implications in age-related disorders. Some potential associations include:

- **Neurodegenerative diseases**: Dysregulation of protein degradation is implicated in disorders such as Parkinson's and Alzheimer's diseases, where FBXO28 could potentially play a role in modulating the levels of misfolded or damaged proteins.
- **Cancer**: As proteostasis becomes less efficient with age, FBXO28's role in targeting specific proteins for degradation may influence oncogenic processes.

### 3. Drug Interactions
Currently, there is limited direct knowledge of drug classes specifically targeting FBXO28. However, drugs that modulate the ubiquitin-proteasome system may indirectly impact the functions involving FBXO28, such as:

- **Proteasome inhibitors (e.g., Bortezomib)**: Used in cancer therapy, which may alter the degradation dynamics of proteins, including those that interact with FBXO28.
- **Antineoplastic agents**: Some agents may influence the cellular pathways that involve F-box proteins, including FBXO28, particularly in cancer treatment contexts.

### 4. Pathways and Biological Processes
FBXO28 is involved in various biological processes, including:

- **Ubiquitin-mediated proteolysis**: FBXO28 is a part of the E3 ubiquitin ligase complex, which is responsible for targeting specific proteins for degradation through ubiquitination.
- **Cell cycle regulation**: Proteins regulated by FBXO28 may play roles in controlling the cell cycle.
- **Signal transduction**: By regulating the stability of phosphorylated substrates, FBXO28 could influence various signaling pathways.

### Conclusion
FBXO28 is a significant player in the ubiquitin-proteasome system, critical for protein turnover and cellular homeostasis. While further research is needed to completely elucidate its roles in aging and disease, its interactions with several key cellular processes underscore its potential impact in health and disease.