### OBSL1 Gene Overview

**Gene Symbol:** OBSL1  
**Location:** Human Chromosome 6 (6q26)

The OBSL1 gene encodes a cytoskeletal adaptor protein that is important for linking the cytoskeleton to the cell membrane. It is a member of the Unc-89/obscurin family and contains numerous immunoglobulin-like domains, along with a central fibronectin type 3 domain. This protein plays a pivotal role in the assembly of the 3M complex, which is critically involved in regulating microtubule dynamics and maintaining genomic integrity.

### 1. Associated Genes
OBSL1 has been linked to several other genes, particularly those involved in cellular processes and signaling pathways. Notably:
- **CUL7**: Encodes a E3 ubiquitin ligase, which interacts with OBSL1 and is vital for processes such as Golgi morphogenesis.
- **FBXW8**: Part of the ubiquitin-protein ligase complex that OBSL1 regulates, impacting various cellular functions.
- **MPTP**: Potential involvement with microtubule-associated proteins as OBSL1 regulates microtubule dynamics.

### 2. Aging and Age-Related Diseases
Research has indicated that mutations in OBSL1 are linked to **3M syndrome type 2**, which is characterized by growth delays, distinctive facial features, and skeletal abnormalities. Although specific studies directly connecting OBSL1 to aging-related diseases are limited, the protein's role in regulating microtubule dynamics and maintaining genomic integrity suggests potential implications in age-associated cellular senescence and diseases characterized by genomic instability, such as cancer.

### 3. Drug Interaction
As of the latest data, there are no specific drugs or drug classes directly documented to interact with OBSL1. However, given its involvement in key cellular processes related to microtubule dynamics, it is plausible that agents which target microtubule stabilization (e.g., taxanes) may indirectly affect the pathways where OBSL1 is involved.

### 4. Pathways and Biological Processes
OBSL1 is involved in several critical cellular pathways and biological processes, including:
- **Microtubule Dynamics**: OBSL1 is a core component of the 3M complex, suggesting an essential role in microtubule stabilization and organization.
- **Ubiquitin-Proteasome Pathway**: As a regulator of the Cul7-RING(FBXW8) ubiquitin ligase, OBSL1 plays a vital function in protein ubiquitination processes that control various cellular functions.
- **Golgi Apparatus Morphogenesis**: It is required for proper localization of CUL7 to the Golgi apparatus, which is critical for maintaining its structure and function.
- **Neuronal Development**: OBSL1 influences dendritic patterning, suggesting a role in neuronal architecture and function.

### Conclusion
The OBSL1 gene encodes a crucial cytoskeletal adaptor protein integral for cellular integrity and function. While its primary association is with 3M syndrome, further investigation into its role in aging and possible therapeutic interactions remains a significant area for ongoing research.