### RPSAP46 Gene Overview

**Gene Symbol:** RPSAP46  
**NCBI Reference:** [RPSAP46 Gene - NCBI](https://www.ncbi.nlm.nih.gov/gene/7109)  
**UniProt Reference:** [RPSAP46 - UniProt](https://www.uniprot.org/uniprot/P0C0A4)  

The RPSAP46 gene encodes a non-coding RNA located in the human genome. It is primarily associated with the regulation of ribosomal protein genes and may play a role in ribosome biogenesis.

### 1. Associated Genes
While specific genes associated directly with RPSAP46 are not extensively documented in summaries, as it serves a regulatory function, it may be related to other genes involved in ribosome biogenesis, ribosomal proteins, or pathways associated with cellular growth and proliferation. Commonly studied genes in the same context may include:

- **RPSA** (Ribosomal Protein S2)
- **RPL-family genes** (Ribosomal Protein L family)
- Other non-coding RNAs that regulate ribosomal activity and biogenesis.

### 2. Aging and Age-Related Diseases
Details specifically connecting RPSAP46 to aging or age-related diseases are limited. However, ribosomal dysfunction and alterations in protein synthesis have been implicated in various age-related conditions, including:

- **Neurodegenerative Diseases:** Decreased protein synthesis and dysfunctional ribosome biogenesis can contribute to conditions like Alzheimer's and Parkinson's disease.
- **Cancer:** Deregulation of ribosomal protein genes and non-coding RNAs may influence tumor growth and cancer progression, which are often exacerbated with aging.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes that have been directly linked to interactions with the RPSAP46 gene mentioned in available literature. However, as a component of ribosomal machinery, it may potentially be indirectly influenced by drugs that target ribosomal pathways or protein synthesis:

- **Antibiotics:** Such as aminoglycosides (e.g., streptomycin) that target bacterial ribosome function, which may have similar implications on eukaryotic ribosomal function.
  
Further research may unveil specific interactions as the understanding of non-coding RNAs and their involvement in therapeutic contexts advances.

### 4. Pathways and Biological Processes
RPSAP46 is primarily involved in the following pathways and biological processes:

- **Ribosome Biogenesis:** Involvement in the assembly and maturation of ribosomes.
- **Regulation of Protein Synthesis:** Plays a role in the overall regulation of mRNA translation and ribosomal function.
- **Cell Proliferation and Growth:** Through its relationship with ribosomal proteins, it may impact cellular growth and the response to cellular stress.

Understanding RPSAP46 in these broader contexts helps to comprehend its potential regulatory roles in fundamental biological processes as well as pathological states.