### PPRC1 Gene Overview

**Symbol:** PPRC1  
**Function:** The PPRC1 gene encodes a protein that acts as a coactivator for transcription factors involved in mitochondrial biogenesis, particularly interacting with Nuclear Respiratory Factor 1 (NRF1). This protein plays a crucial role in the regulation of genes related to energy metabolism and cell growth in response to various proliferative signals.

### 1. Associated Genes
While PPRC1 has known associations with NRF1 and CREB as mentioned, it is also indirectly associated with genes involved in:
- **PPARGC1A (PPAR-gamma coactivator 1 alpha)**: A direct relative of PPRC1, crucial in the regulation of mitochondrial biogenesis.
- **NRF2 (Nuclear factor erythroid 2-related factor 2)**: Involved in antioxidant response and cellular redox state regulation.
- **TFAM**: Mitochondrial transcription factor A, essential for mitochondrial DNA maintenance and function.

### 2. Aging and Age-related Diseases
PPRC1 is implicated in age-associated processes and diseases due to its role in mitochondrial function and energy metabolism. Key details include:
- **Mitochondrial Dysfunction**: Impaired mitochondrial function is a hallmark of aging and is associated with age-related diseases such as Alzheimer’s and Parkinson’s disease. PPRC1's influence on mitochondrial biogenesis suggests that it may play a role in the maintenance of cellular energy levels and prevention of age-related decline.
- **Metabolic Disorders**: Dysregulation of genes associated with PPRC1 can contribute to metabolic disorders, including type 2 diabetes and obesity, conditions that are often exacerbated by aging.

### 3. Drug Interactions
Currently, specific drugs or drug classes that directly interact with PPRC1 have not been extensively characterized in the literature. However, general classes of compounds that influence mitochondrial biogenesis, and may de facto interact with PPRC1 pathways, include:
- **PPAR Agonists**: Such as thiazolidinediones (e.g., rosiglitazone), which may indirectly affect PPRC1 activity through pathways involving energy metabolism.
- **Activator Compounds**: Compounds that target AMPK (AMP-activated protein kinase) may influence mitochondrial function and hence PPRC1 activity, although this has not been directly proven.

### 4. Pathways and Biological Processes
PPRC1 is involved in numerous biological processes and pathways, including:
- **Mitochondrial Biogenesis**: Through activation of NRF1 target genes, facilitating DNA transcription and replication required for mitochondrial replication.
- **Response to Energy Stress**: Participating in cellular responses to increasing energy demands, linking signals from the metabolic state of the cell to mitochondrial function.
- **Regulation of Cell Growth**: Involvement in the signaling pathways required for growth and proliferation, likely through CREB-mediated transcriptional activation.
- **Oxidative Stress Response**: Potential involvement in pathways that manage cellular responses to oxidative stress due to its relationship with NRF factors that also influence antioxidant gene expression.

In summary, PPRC1 is a significant player in mitochondrial biogenesis and energy metabolism, with implications in aging, metabolic diseases, and interactions with other signaling pathways that regulate cellular health. Further research could elucidate more detailed drug interactions and functional relationships with other genes in the context of health and disease.