### GPR182 Gene Overview

**Gene Symbol:** GPR182  
**Description:** The GPR182 gene encodes a seven-transmembrane G-protein coupled receptor that is suggested to act as a receptor for the vasodilator peptide adrenomedullin. It is classified as an orphan receptor, meaning that its endogenous ligand has yet to be definitively identified. 

### 1. Associated Genes
GPR182 may be functionally associated with various other genes, particularly those involved in cardiovascular function and G-protein signaling. Possible associated genes include:

- **ADM (Adrenomedullin):** The peptide ligand implicated in the function of GPR182.
- **GPR1:** Another G-protein coupled receptor that might share pathways or regulatory mechanisms.
- **GNAQ and GNA11:** G-protein subunits that could serve roles in signal transduction mediated by GPR182.

While specific associations may vary based on the context of the study (cell type, differentiation state, etc.), these genes are particularly relevant to GPR182's function.

### 2. Aging and Age-related Diseases
The direct implications of GPR182 in aging or age-related diseases are not as extensively documented. However, given its role in cardiovascular function, there are several potential links:

- **Cardiovascular Aging:** GPR182's association with adrenomedullin suggests a role in vascular health, which may decline with age, contributing to conditions such as hypertension or heart failure.
- **Inflammation:** Changes in G-protein signaling related to aging could influence age-associated inflammatory processes, suggesting a broader role in healthspan and diseases associated with aging, although specific research directly linking GPR182 to these processes remains limited.

### 3. Drug Interactions
Currently, there are no well-documented drugs specifically targeting GPR182 listed in major databases like DrugBank or ChEMBL. However, given its potential role in cardiovascular dynamics, indirect interactions with classes of drugs such as:

- **Vasodilators:** Possible indirect effects through pathways involving endogenous ligands.
- **Antihypertensive agents:** Drugs that affect vascular reactivity and influence adrenomedullin levels could also interact with GPR182 functionality.

### 4. Pathways and Biological Processes
GPR182 is involved in several biological processes and signaling pathways:

- **G-protein Coupled Receptor Signaling Pathway:** As a GPCR, GPR182 participates in numerous downstream signaling cascades once activated.
- **Vasodilation:** Due to its proposed interaction with adrenomedullin, it is likely involved in mediating vascular smooth muscle relaxation and thus plays a critical role in blood pressure regulation.
- **Cell Proliferation and Inflammation:** GPCRs are often involved in modulating cellular responses to external stimuli; thus, GPR182 may influence inflammatory responses and cellular growth processes.

In summary, GPR182 is a G-protein coupled receptor implicated in cardiovascular regulation, with potential associations with other relevant genes, and while it has unexplored connections with age-related mechanisms and therapeutics, its exact role in these areas merits further study.