### GMPR Gene Overview

**Gene Symbol**: GMPR  
**Full Name**: Guanosine monophosphate reductase

**Function**: The GMPR gene encodes an enzyme that plays a critical role in purine metabolism. It specifically catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). This process is essential for the conversion and recycling of purines, as it helps maintain the balance of adenine (A) and guanine (G) nucleotides within cells.

### Associated Genes
While specific associative genes may not be universally acknowledged, GMPR is involved in several metabolic pathways that include:

- **ADA** (Adenosine deaminase): Involved in the purine salvage pathway.
- **AMPD1** (Adenosine monophosphate deaminase 1): A key enzyme in purine metabolism that works closely with GMPR's functions.
- **NME1** (NME/NM23 nucleoside diphosphate kinase 1) and other nucleotides-linked genes may also interact metabolically, especially in cellular energy processes.

### Known Details Related to Aging or Age-Related Diseases
While there is limited direct evidence linking GMPR to aging or age-related diseases, disturbances in purine metabolism are known to be involved in several conditions associated with aging, including:

- **Cardiovascular diseases**: Altered nucleotide metabolism can affect vascular function.
- **Neurodegenerative disorders**: Metabolite perturbations may contribute to diseases like Alzheimer’s and Parkinson’s which have been linked to changes in nucleotide concentrations.
- **Cancer**: Since GMPR is involved in maintaining nucleotide balance, dysregulation may lead to uncontrolled cell proliferation characteristic of cancer.

### Drug Interactions
As of the last update, specific drugs directly interacting with GMPR are not commonly specified in literature. However, its involvement in the purine metabolism pathways implies that substrates of the enzyme (like GMP or IMP) might influence or be affected by treatment with purine analogs or drugs that affect nucleotide metabolism, such as:

- **Purine analogs**: e.g., Azathioprine, Mercaptopurine used in cancer or autoimmune disease treatment.
- **Allopurinol**: Often used for gout can indirectly affect GMPR function by reducing purine breakdown products.

### Pathways and Biological Processes Involved
The GMPR gene is involved in several critical biological pathways, including:

1. **Purine metabolism**: Specifically, the purine salvage pathway where it helps convert GMP to IMP, playing a vital role in recycling nucleotides.
2. **Nucleotide biosynthesis**: GMPR contributes to the maintenance of nucleotide pools necessary for DNA and RNA synthesis.
3. **Metabolic pathways of nucleotides**: It interacts with various metabolic pathways crucial for cellular energy and signaling functions.

### Summary
The GMPR gene is crucial for maintaining the balance of purine nucleotides through the reduction of GMP to IMP. Its involvement in purine metabolism suggests significant implications for cellular functions related to aging, cancer, and potential drug interactions that may alter nucleotide metabolism. More research may provide insights into its specific roles in these contexts.