### CDKN1C Gene Overview

**Gene Symbol**: CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C)  
**Location**: Chromosome 11p15.5  
**Function**: The CDKN1C gene encodes a potent inhibitor that regulates the cell cycle by inhibiting cyclin-dependent kinases (CDKs), particularly those involved in the G1 phase of the cell cycle. It plays a crucial role in controlling cell proliferation and maintaining the non-proliferative state of cells.

### 1. Associated Genes
CDKN1C is associated with several other genes that play roles in cell cycle regulation, tumor suppression, and imprinted gene regulation. Notably, the following genes might be mentioned in relation to CDKN1C:
- **CDK2**: A cyclin-dependent kinase, which is inhibited by CDKN1C.
- **CDK4**: Another cyclin-dependent kinase impacted by CDKN1C.
- **CDKN2A**: This gene also encodes a cyclin-dependent kinase inhibitor and shares functional linkages in relation to cell cycle regulation.
- **IGF2**: Insulin-like growth factor 2, which is associated with the imprinting region of the 11p15 locus and is known to be involved in growth and development, showing interaction within the same genomic imprinting cluster.

### 2. Aging and Age-Related Diseases
While the primary role of CDKN1C is within cell proliferation and tumor suppression, its involvement in aging comes from its function as a negative regulator of the cell cycle. Dysregulation of CDKN1C can lead to uncontrolled cell proliferation, which is a hallmark of many age-related diseases, particularly cancer. Furthermore, CDKN1C has been noted for its involvement in the regulation of stem cell populations and differentiation, which could be of relevance in aging research. 

Mutations or epigenetic changes in CDKN1C have been linked to various cancers, which are often age-related.

### 3. Drug Interactions
As of the last update, specific drugs that directly target CDKN1C are not well defined. However, agents that influence cell cycle regulation (like certain chemotherapeutic agents) may indirectly affect CDKN1C or pathways involving it. Drug classes known to affect cell cycle dynamics include:
- **CDK inhibitors**: These drugs may interact with the pathways regulated by CDKN1C, although they are not direct inhibitors of CDKN1C itself.
- **Chemotherapeutics**: Such as taxanes and vinca alkaloids that prevent cell division. 

Research around more specific small molecules targeting CDKN1C-related pathways is ongoing, particularly in tumor biology.

### 4. Pathways and Biological Processes
CDKN1C is involved in several key biological pathways and processes, including:
- **Cell Cycle Regulation**: Particularly the transition from G1 to S phase, where it inhibits CDK activity.
- **Regulation of Apoptosis**: By controlling the growth and maintenance of cellular populations.
- **Developmental Processes**: Its imprinting and expression patterns are involved in growth and development.
- **Cancer Pathways**: Dysregulation of CDKN1C is implicated in various oncogenic processes and tumorigenesis.
- **Imprinting Control**: CDKN1C is part of the imprinted gene cluster on chromosome 11p15, directly linked to genomic imprinting mechanisms.

Overall, CDKN1C functions as a critical regulatory hub in cell cycle control, developmental processes, and the maintenance of cellular homeostasis, with significant implications for aging, cancer, and other diseases.