The ITGA5 gene encodes the integrin alpha-5 subunit, which plays a key role in various cellular processes, including adhesion, signaling, and extracellular matrix interactions. Below are additional details on the gene, including associations, implications in aging, drug interactions, and pathways.

### 1. Associated Genes
In addition to its association with ITGB1 (integrin beta-1), the following genes are known to interact with or are associated with ITGA5:
- **ITGB3**: Forms a heterodimer with ITGA5, involved in cell adhesion and signaling.
- **FBN1**: Fibrillin-1, which is a ligand for ITGA5:ITGB1.
- **FN1**: Fibronectin, another ligand for the integrin complex.
- **PLA2G2A**: Phospholipase A2 Group IIA, interacting with integrin and influencing cell adhesion.
- **IL1B**: Interleukin 1 beta, which involves ITGA5 interactions in signaling pathways.

### 2. Aging and Age-Related Diseases
Research indicates that integrins, including ITGA5, may play roles in aging and age-related diseases:
- **Cellular Senescence**: Alterations in integrin signaling can affect cell migration and adhesion properties, leading to the accumulation of senescent cells, which are linked to aging.
- **Cancer**: Increased expression of ITGA5 has been correlated with tumor progression and metastasis in various cancers, including lung cancer. Older individuals often have a higher risk for cancers, potentially due to increased expression of tumor-promoting genes like ITGA5.
- **Fibrosis**: ITGA5 is implicated in fibrotic diseases, which is more prevalent in aging populations, as extracellular matrix remodeling becomes dysregulated.

### 3. Drug Interactions
While there may not be specific drugs that target ITGA5 directly, there are classes of drugs that can influence integrin function or are related to pathways involving ITGA5:
- **Integrin Inhibitors**: Specific small molecules and monoclonal antibodies that target integrins are being developed for therapeutic use in cancer and inflammatory diseases.
- **Nonsteroidal anti-inflammatory drugs (NSAIDs)**: These can indirectly affect integrin signaling pathways associated with inflammation.
- **Chemotherapeutic agents**: Some cancer treatments seek to target pathways involving integrins, including those associated with tumor invasion and metastasis.

### 4. Pathways and Biological Processes
ITGA5 is involved in several important biological processes and signaling pathways:
- **Cell Adhesion**: Mediates connections between cells and between cells and the extracellular matrix, essential for tissue integrity.
- **Signal Transduction**: Engages in intracellular signaling cascades that regulate cell proliferation and migration.
- **Wound Healing**: Contributes to processes necessary for tissue repair following injury.
- **Focal Adhesion Formation**: Integrates signals from the extracellular environment influencing cellular responses.
- **Inflammatory Response**: Interacts with immune signaling molecules like IL1B, affecting the overall immune response.

In summary, ITGA5 is a significant player in cellular adhesion and signaling, with implications in cancer progression, aging, and potential therapeutic targets in various diseases.