### RRP15 Gene Overview

**Gene Symbol**: RRP15  
**Description**: The RRP15 gene encodes a protein involved in nucleolar activity and ribosomal maturation. It co-purifies with human nucleoli and shares homology with a yeast protein that is part of the pre-60S ribosomal particles, indicating a conserved role in ribosome biogenesis.

### 1. Associated Genes
While specific gene associations for RRP15 are not extensively documented, it is generally associated with other genes involved in ribosome biogenesis and nucleolar function. Such genes include:
- **RPS28**: A component of the ribosomal 40S subunit.
- **RPL11**: A ribosomal protein component of the 60S subunit.
- **NPM1**: Nucleophosmin, a nucleolar protein implicated in ribosome biogenesis and tumorigenesis.
- **RPL3**: Another ribosomal protein involved in 60S subunit biogenesis.

### 2. Aging & Age-Related Diseases
Research connecting RRP15 directly to aging or age-related diseases is limited. However, due to its role in ribosome biogenesis, disruptions in its function might be implicated in age-related cellular degradation. Problems in ribosomal assembly have been associated with:
- **Cancer**: Altered ribosomal function and increased ribosome production in cancer cells.
- **Neurodegenerative Diseases**: Ribosomal dysfunction is also noted in conditions such as Alzheimer's disease, though specific links with RRP15 have not been established.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes documented that directly interact with RRP15. However, it is important to consider that compounds affecting general ribosome biogenesis or nucleolar function could indirectly influence the activity of RRP15. Examples include:
- **Antibiotics (e.g., Aminoglycosides)**: Target bacterial ribosomal function but could potentially inform studies about eukaryotic ribosome dynamics.
- **Citrullination inhibitors**: Since PADI4 modifies proteins through citrullination, inhibitors of PADI4 could alter RRP15 activity, but this is indirect.

### 4. Pathways and Biological Processes
RRP15 is involved in several key biological processes and pathways:
- **Ribosome Biogenesis**: Crucial for the assembly and maturation of ribosomal subunits, specifically the 60S subunit, as indicated by its yeast homolog.
- **RNA Metabolism**: Plays a role in processes related to rRNA processing and modification.
- **Nucleolar Function**: Contributes to the formation of nucleolar structures and the regulation of nucleolar stress responses.

### Summary
The RRP15 gene encodes a nucleolar protein essential for ribosomal biogenesis and may indirectly influence aging and age-related diseases due to its functional role in ribosome assembly. It possibly interacts with various ribosomal and nucleolar-associated proteins, and while direct drug interactions remain unclear, its involvement in fundamental cellular processes like ribosome biogenesis makes it a relevant subject for research in cellular aging and cancer biology.