### ADGRL3 Gene Summary

**Gene Symbol**: ADGRL3  
**Location**: Chromosome 3  
**Gene Type**: Protein-coding gene  
**Protein Family**: Latrophilins, a subfamily of G-protein coupled receptors (GPCRs)  

**Function**:  
ADGRL3 is involved in cell adhesion and signal transduction, particularly in the nervous system. It interacts with FLRT2 and FLRT3, which are important for neuron guidance and the development of glutamatergic synapses. This gene is crucial for determining connectivity rates among principal neurons in the cortex.

### Additional Information

1. **Associated Genes**:
   - **FLRT2 (Fibronectin Leucine-Rich Transmembrane Protein 2)**: Involved in cell adhesion and signal transduction processes.
   - **FLRT3 (Fibronectin Leucine-Rich Transmembrane Protein 3)**: Shares functional roles similar to FLRT2.
   - **ADGRL1** and **ADGRL4**: Other members of the latrophilin family, which may also have interacting pathways.
   - **NLGN1 (Neuroligin 1)**: Involved in synaptic function and could have overlapping roles in synapse development.
  
2. **Aging and Age-Related Diseases**:
   - There is increasing evidence that alterations in neuronal connectivity, possibly mediated by ADGRL3, may be involved in neurodegenerative diseases such as Alzheimer's disease. Diminished synaptic connectivity is a hallmark of aging and age-related cognitive decline, suggesting that ADGRL3 could play a role in age-related neuronal plasticity.
   - ADGRL3 also may impact processes related to neurodevelopmental and psychiatric disorders, which could be affected by aging.

3. **Drug Interactions**:
   - Although specific drug interactions with ADGRL3 are not well-documented, as it is a GPCR, it could theoretically interact with classes of drugs that target GPCR pathways, such as:
     - Antidepressants (like SSRIs)
     - Antipsychotics
     - Neuromodulators that interact with synaptic pathways may affect its function indirectly.
   - Further studies would be required to identify specific agents or modulators that target ADGRL3 directly.

4. **Pathways and Biological Processes**:
   - **Cell Adhesion**: Critical for establishing connections between neurons.
   - **Neurogenesis**: Involved in neuronal development and differentiation.
   - **Glutamatergic Synapse Development**: Key to proper synaptic function, particularly in the cortex.
   - **Signal Transduction via GPCR pathways**: Plays a role in transmitting signals from outside the cell to elicit appropriate cellular responses.
   - **Neuronal Guidance during Development**: Involved in directing neurons to their proper locations during development.

### Conclusion

ADGRL3 is an essential gene in the context of neuroscience, contributing to cell adhesion, neuronal connectivity, and the development of synapses specifically in the cortex. Its broader implications in aging, neurodevelopmental disorders, and potential connections to drug mechanisms underscore its importance within both normal physiological processes and pathological conditions. Continued research may elucidate further functional interactions and clinical significance related to ADGRL3.