### PCNPP2 Gene Overview

**Gene Symbol:** PCNPP2  
**Aliases:** Not widely known by additional aliases in the literature  
**Location:** Chromosome 2p23.3  

**Description:**  
PCNPP2 (Prolylcarboxypeptidase 2) is implicated in the regulation of bioactive peptides by removing the C-terminal proline residues from peptide substrates. This activity suggests a role in various physiological processes involving peptide signaling. The gene is part of a family of prolylcarboxypeptidases that are often involved in the metabolism of neuropeptides and other signaling molecules.

### 1. Associated Genes

While specific gene associations can vary, PCNPP2 may be co-expressed or functionally related to genes involved in neuropeptide signaling and metabolism. Other genes connected through various biological pathways may encompass:

- **PCNPP**: The gene closely related to prolylcarboxypeptidases.
- **NPPB**: Involved in the cardiac function and may be relevant in peptide signaling networks.
  
These genes could be influenced by the same signaling pathways or regulatory mechanisms. 

### 2. Aging and Age-Related Diseases

Research on PCNPP2 directly linking it to aging or age-related diseases is limited. However, given its role in processing neuropeptides, which are involved in numerous neurodegenerative conditions and age-related physiological changes (such as cognitive decline), it is conceivable that variations in PCNPP2 might influence susceptibility to these diseases.

To further elucidate any specific roles, additional research regarding gene expression changes with age or in age-related contexts would be needed.

### 3. Drug Interactions

As of the latest data, there is no direct evidence linking specific drugs or drug classes to PCNPP2. Due to its functional role in cleaving peptides, it may interact indirectly with drugs affecting neuropeptide levels or functions, but specific interactions have not been well established in current literature.

### 4. Pathways and Biological Processes

PCNPP2 is associated with several biological pathways including:

- **Neuropeptide signaling pathways**: Given its potential role in processing neuropeptides, it may affect pathways involved in neural communication, stress response, and metabolic regulation.
- **Peptide metabolism and signaling**: This includes influence over a variety of biological functions such as hormone signaling, pain modulation, and homeostasis.
  
At a molecular level, the biological processes may also include:

- **Protein processing and modification**: PCNPP2 likely plays a role in the post-translational modification of proteins, particularly those involved in peptide signaling.
  
### Conclusion

While the PCNPP2 gene is part of a broader network of genes involved in peptide metabolism, specific associations, roles in aging, and drug interactions warrant further investigation. Ongoing studies may help clarify any direct implications of this gene in health and disease, especially concerning neurodegenerative conditions.