The **INSRR** (Insulin Receptor Related Receptor) gene encodes a protein that plays a role in several cellular processes, particularly in actin cytoskeleton reorganization and sensing changes in extracellular pH through its receptor tyrosine kinase activity. Below are detailed insights into the gene based on your requests:

### 1. Associated Genes
**INSRR** is known to be functionally associated with several other genes, including:
- **IRS1 (Insulin Receptor Substrate 1)**: A critical mediator of insulin signaling involved in glucose metabolism.
- **AKT1 (RAC-alpha serine/threonine-protein kinase)**: Part of the signaling pathway activated by INSRR, involved in regulating cell growth and survival.
- Other potential interacting partners may include various components of the insulin signaling pathway, though specific associations beyond IRS1 and AKT1 often require experimental validation.

### 2. Aging and Age-Related Diseases
While direct associations between INSRR and aging or age-related diseases are not extensively documented, its involvement in metabolic pathways suggests a potential role:
- **Type 2 Diabetes**: Altered insulin signaling is a hallmark of type 2 diabetes, and since INSRR is related to insulin receptor activity, it may be implicated in the pathophysiology of metabolic disorders.
- **Neurodegeneration**: Changes in insulin signaling have been implicated in neurodegenerative diseases like Alzheimer's disease, hinting at a potential indirect role for INSRR in age-related cognitive decline.
- Studies exploring the expression levels of INSRR in aging tissues may provide further insights into its relevance.

### 3. Drug Interactions
Currently, there is limited specific information on drugs that interact directly with INSRR. However, drugs affecting insulin signaling, such as:
- **Insulin**: Used for managing diabetes.
- **Metformin**: An antidiabetic medication that may have effects on insulin signaling pathways.
- **GLP-1 receptor agonists**: These enhance insulin secretion and may interact with insulin signaling pathways.

Research into targeted therapies for diseases associated with insulin signaling will be vital in uncovering direct drug-gene interactions.

### 4. Pathways and Biological Processes
**INSRR** is involved in several biological pathways and processes, including:
- **Insulin signaling pathway**: Supports cellular glucose uptake and metabolic regulation.
- **Actin cytoskeleton organization**: Implicated in cell shape and movement.
- **Cellular response to pH**: Responds to changes in extracellular pH, influencing cellular behavior.
- **Protein autophosphorylation**: Modulates receptor activity and signal transduction.
- **Signal transduction pathways influencing metabolism**: Particularly through modulation of downstream targets like IRS1 and AKT1.

Overall, the INSRR gene plays a multifaceted role in cellular signaling, particularly in relation to insulin and pH, and warrants further research to uncover more associations, particularly in aging and metabolic diseases.