The EDN2 gene (endothelin 2) encodes a member of the endothelin protein family, which includes powerful vasoconstrictive peptides. Below is a detailed description based on your request.

### 1. Associated Genes
The EDN2 gene is associated with several other genes, particularly those involved in cardiovascular functions and endothelial responses. Some of these include:
- **EDN1 and EDN3**: Other members of the endothelin family, which also participate in similar signaling pathways.
- **ETA and ETB receptors (EDNRA and EDNRB)**: Receptors that bind endothelins and mediate their effects.
- **ACE (Angiotensin-Converting Enzyme)**: Involved in the regulation of blood pressure and fluid balance.
- **NOS3 (Nitric Oxide Synthase 3)**: Plays a role in vasodilation, countering the effects of vasoconstrictors like endothelins.

### 2. Aging and Age-Related Diseases
Alterations in the expression of the EDN2 gene can be linked to:
- **Hypertension**: Increased levels of endothelins like EDN2 can lead to elevated blood pressure, common in aging populations.
- **Cardiovascular diseases**: Dysregulation of endothelin pathways is observed in conditions such as heart failure, which commonly affects older adults.
- **Cancer**: Given that altered expression levels of EDN2 are implicated in tumorigenesis, there may be connections between aging and cancer through the regulation of this gene.
- **Neurodegenerative diseases**: Endothelins may contribute to vascular changes affecting neural health, which can be associated with age-related neurodegeneration.

### 3. Drug Interactions
Drugs that are known to interact with EDN2 or its pathways include:
- **Endothelin Receptor Antagonists (ERAs)**: Such as Bosentan and Ambrisentan, which are used primarily in the treatment of pulmonary arterial hypertension by blocking endothelin receptor activity.
- **Vasodilators**: Such as Nitroglycerin and other nitric oxide donors, which may counteract the vasoconstrictive effects of endothelins.

### 4. Pathways and Biological Processes
EDN2 is involved in several critical biological processes and signaling pathways, including:
- **Vasoconstriction and Blood Pressure Regulation**: The binding of EDN2 to its receptors leads to vasoconstriction, thereby regulating blood pressure.
- **Cell Proliferation and Migration**: Endothelins can stimulate proliferation and migration of vascular smooth muscle cells, an important process in atherosclerosis.
- **Inflammation**: Involvement in inflammatory responses through signaling pathways that can be activated by endothelins.
- **Reproductive Processes**: Specifically indicated in ovulation, where EDN2 may influence ovarian function and follicular development.

Overall, the EDN2 gene plays a multifaceted role in key physiological processes and is involved in various pathological conditions, particularly those related to vascular and cardiovascular health. Its interactions and regulatory mechanisms underscore its significance in both health and disease.