### NPBWR2 Gene Overview

**Gene Symbol**: NPBWR2  
**Entrez Gene ID**: 11486  
**Location**: Chromosome 1q31.3  

The NPBWR2 gene encodes an integral membrane protein that functions as a G protein-coupled receptor (GPCR). It is primarily involved in signaling pathways related to neuropeptides, with specificity for neuropeptides B and W. This receptor displays structural similarities to some opioid and somatostatin receptors, indicating functional diversity within the GPCR family.

### 1. Associated Genes

While NPBWR2 may have functional associations with several genes due to its involvement in signaling pathways, specific genes directly linked or co-regulated with NPBWR2 are not widely documented beyond GPR7 (which is structurally similar). However, related signaling partners may include other neuropeptide receptors or GPCRs such as:

- **GPR7**: Similar receptor often involved in similar neuropeptide signaling.
- **OPRD1** (opioid receptor delta 1): Related due to the GPCR family's involvement in neuropeptide signaling.
- **SSTR** (somatostatin receptors): Involved in various neuroendocrine functions.

### 2. Aging and Age-Related Diseases

Research on the role of NPBWR2 in aging and age-related disorders is still limited; however, some indirect associations infer that since it is involved in the regulation of the neuroendocrine system and food intake, variations in NPBWR2 function could potentially play a role in:

- **Metabolic syndromes**: Given its role in food intake regulation, variations in NPBWR2 may be linked to obesity and its associated metabolic issues as individuals age.
- **Neurodegenerative diseases**: Alterations in neuropeptide signaling pathways during aging may implicate NPBWR2 in conditions such as Alzheimer's disease and other cognitive disorders.
- **Mood disorders**: Given the regulation of stress and appetite, there could be implications for age-related depression and anxiety disorders.

### 3. Drug Interactions

Drugs or drug classes that may interact with pathways involving NPBWR2 could include:

- **Opioids**: Given the receptor's interaction with opioid ligands.
- **Antidepressants**: Certain antidepressants acting on GPCRs may have downstream effects on NPBWR2 signaling.
- **Neuropeptide modulators**: Research might indicate potential therapeutic agents aimed at modulating neuropeptides B and W interactions.

### 4. Pathways and Biological Processes

NPBWR2 is involved in several biological pathways and processes, which can include:

- **Neurotransmission and signal transduction**: As a GPCR, it plays a part in transmitting signals from neuropeptides influencing neuronal activities.
- **Regulation of neuropeptides**: Interfering with the processing and signaling of neuropeptides related to appetite and energy homeostasis.
- **Behavioral pathways**: Contributing to processes related to mood regulation and stress response.

### Summary

The NPBWR2 gene encodes an integral membrane G protein-coupled receptor playing a crucial role in neuropeptide signaling, affecting metabolic regulation and possibly age-related health contexts. While specific associations with other genes, aging, and drug interactions warrant further research, this receptor's functional implications are significant within neurobiology and related therapeutic potentials.