### INO80E Gene Overview

**Gene Symbol:** INO80E  
**Predicted Functions:** DNA recombination, DNA repair, chromatin remodeling.  
**Cellular Localization:** Nucleus (nucleolus and nucleoplasm).  
**Complex Association:** Part of the INO80 chromatin remodeling complex, which plays a crucial role in transcriptional regulation, DNA replication, and potentially in DNA repair processes.

### 1. Associated Genes
The INO80E gene is primarily known for its role within the INO80 complex. While specific genes directly associated with INO80E may not be detailed in the summaries provided, the following genes are generally implicated in the function of the INO80 complex or related chromatin remodeling processes:
- **INO80**: The core component of the INO80 complex.
- **SWR1**: Another chromatin remodeling complex that interacts with INO80 pathways.
- **ARP5**, **ARP8**, **CDC31**, and **SNF2**: Other members of the chromatin remodeling complexes or pathways that may interact or have relationships with INO80E.

### 2. Aging and Age-Related Diseases
While direct associations of the INO80E gene with aging or specific age-related diseases are less commonly reported, chromatin remodeling complexes, including INO80, are known to be involved in processes that can influence cellular senescence, genomic stability, and aging. Key points include:
- **Genomic Stability**: Alterations in INO80 function may result in decreased genomic stability, which is a hallmark of aging and may contribute to age-related diseases.
- **Cancer**: Given that DNA repair mechanisms are crucial for preventing mutations that can lead to cancer, dysfunctions in INO80E may increase susceptibility to age-related cancers, although direct evidence is limited.
- **Cellular Senescence**: Chromatin remodeling is critical for regulating gene expression changes that occur with cellular senescence, potentially linking INO80E to aging processes.

### 3. Drug Interactions
As of the latest available data, there are no specific drugs or drug classes widely reported to interact directly with the INO80E gene. However, potential avenues for research include:
- **Histone Deacetylase Inhibitors (HDACi)**: Given that INO80E functions in chromatin remodeling, some HDAC inhibitors could have effects on its activity indirectly through modulation of chromatin structure.
- **Antineoplastic Agents**: Some cancer treatments that target DNA repair mechanisms may indirectly affect INO80E function.

### 4. Pathways and Biological Processes
The INO80E gene is involved in several important biological processes and pathways, including:
- **DNA Repair Pathways**: Particularly in homologous recombination and other DNA damage repair pathways.
- **Chromatin Remodeling**: Essential for modifying chromatin structure to facilitate transcription regulation and DNA replication.
- **Gene Expression Regulation**: Influences transcription factor accessibility to DNA by remodeling chromatin.

#### Additional Pathways
- **Cell Cycle Regulation**: Participation in pathways controlling cell cycle progression and ensuring genomic integrity during cell division.
- **Nucleotide Excision Repair**: Some evidence suggests involvement in pathways related to the repair of DNA lesions.

### Conclusion
The INO80E gene plays a pivotal role in critical cellular processes like DNA repair and chromatin remodeling through its association with the INO80 complex. While various genes and pathways relate to INO80E, further research is needed to clarify its role in aging and age-related diseases and to identify any direct therapeutic interactions.