### KLHL15 Gene Overview

**Gene Symbol:** KLHL15  
**Function:** The KLHL15 gene encodes a protein that is a member of the kelch-like family, featuring a characteristic domain structure with an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain, and C-terminal kelch repeat motifs. The KLHL15 protein functions as a substrate-specific adapter for the CUL3 E3 ubiquitin-protein ligase complex, engaging in ubiquitination processes relevant for protein turnover and cellular regulation.

### Associated Genes
While the summaries provided focus on PPP2R5B (a component of protein phosphatase 2A) and RBBP8 (Ctd|b-factor involved in DNA-end resection), other notable genes that have been associated with KLHL15 include:
- **CUL3:** As the primary partner in the E3 ubiquitin ligase complex.
- **RBBP8 (CtIP):** Specifically mentioned in relation to DNA damage response but can be linked to other proteins involved in DNA repair pathways.
- **Other potential miRNA or protein ubiquitination targets may indirectly associate with KLHL15 but may not be explicitly documented.**

### Aging and Age-Related Diseases
Although direct research on KLHL15 in the context of aging is limited, the gene’s role in the DNA damage response suggests potential implications in age-related diseases:
- **DNA Damage Accumulation:** As cells age, DNA damage can accumulate, leading to functional decline and age-related diseases, including cancer. KLHL15’s involvement in ubiquitination and the regulation of proteins like RBBP8, which influences DNA repair pathways, suggests it may play a role in cellular aging processes.
- **Neurodegenerative Diseases:** Age-related deficits in DNA repair mechanisms are often implicated in neurodegenerative diseases, offering a potential indirect link to KLHL15.

### Drug Interactions
As of the latest data, specific drugs or drug classes directly targeting KLHL15 have not been extensively documented. However:
- **Proteasome Inhibitors:** Given KLHL15's involvement in ubiquitination and proteasomal degradation, classes of drugs like bortezomib, which inhibit proteasomes, might indirectly relate to the pathways involving KLHL15.
- Ongoing research may uncover specific targetable interactions.

### Pathways and Biological Processes
KLHL15 is involved in several critical biological processes and pathways:
1. **Ubiquitin-Mediated Proteolysis:** Essential for protein degradation and regulation of cellular homeostasis.
2. **DNA Damage Response:** Particularly involved in the non-homologous end joining (NHEJ) repair pathway, promoting survival during DNA damage events.
3. **Cell Cycle Regulation:** Implicit due to its role in regulating key proteins associated with cell division and repair mechanisms.
4. **Cytoskeletal Organization:** Functions that may imply roles in cellular structure and motility through interactions with cytoskeletal components.

In summary, the KLHL15 gene plays an integral role in cellular regulation through its functions in ubiquitination and DNA damage response, potentially impacting aging and related diseases. While direct pharmacological targets are undefined, its pathways of involvement provide a fertile area for research into therapeutic interventions.