### CRTC3-AS1 Gene Overview

**Gene Symbol:** CRTC3-AS1  
**Gene Type:** Long non-coding RNA (lncRNA)  
**Location:** Chromosome 19

CRTC3-AS1 (cAMP responsive element binding protein regulated transcript 3 antisense RNA 1) is a long non-coding RNA that plays a significant role in various regulatory pathways at the transcriptional level. Although its primary function is still under investigation, it is mainly thought to be involved in the regulation of gene expression associated with metabolic processes.

### Associated Genes

CRTC3-AS1 has been linked to several genes, including:

- **CRTC3:** As the name implies, it is an antisense transcript related to the CRTC3 gene, which encodes a protein critical for transcriptional regulation.
- **CREB1:** A key transcription factor and a potential target of CRTC3 activity.
- **CYP1A1:** A gene involved in drug metabolism and associated with xenobiotic responses.

Other genes that may be associated or co-expressed with CRTC3-AS1, based on functional studies or bioinformatics approaches, include those involved in cell metabolism, growth, and stress responses.

### Aging and Age-Related Diseases

Research has suggested that changes in the expression levels of long non-coding RNAs, including CRTC3-AS1, may play roles in age-related diseases such as:

- **Cancer:** Alterations in lncRNA expression have been associated with tumor progression and metastasis.
- **Cardiovascular Diseases:** Potential involvement in pathways related to lipid metabolism and inflammation which are critically linked to age-related cardiovascular conditions.
- **Neurodegenerative Disorders:** lncRNAs have been implicated in neuroinflammation and stress response mechanisms that may contribute to conditions like Alzheimer's disease.

As of now, specific mechanisms directly linking CRTC3-AS1 to aging and age-related diseases remain to be fully elucidated.

### Drug Interactions

There are no specific drugs or drug classes that are historically known to have a direct interaction with CRTC3-AS1 as of the current knowledge base. However, the gene's involvement in cellular processes may influence cellular responses to certain pharmacological agents, especially those targeting metabolism and signaling pathways in cancer or metabolic diseases.

### Pathways and Biological Processes

CRTC3-AS1 is suggested to partake in several biological processes, including:

- **Regulation of Gene Expression:** It may modulate the expression of neighboring genes, particularly those involved in metabolic pathways.
- **cAMP Signaling Pathway:** Given its relationship to CRTC3, which is regulated by the cAMP cascade, CRTC3-AS1 might play a role in this critical signaling pathway.
- **Cellular Response to Stress:** Its potential involvement in metabolic responses suggests a role in how cells adapt to various stressors.

### Conclusion

While CRTC3-AS1 is a long non-coding RNA with emerging roles in gene expression regulation, its full functional implications in aging, drug interactions, and specific biological pathways are still major areas of ongoing research. More studies are needed to clarify CRTC3-AS1’s exact regulatory mechanisms and its potential therapeutic implications.