### DIAPH3-AS1 Gene Overview

The **DIAPH3-AS1** gene is classified as an antisense RNA gene and is located on chromosome 5. It is thought to be involved in the regulation of gene expression through mechanisms such as RNA interference or possibly by acting as a competing endogenous RNA. 

### 1. Associated Genes

While the specific NCBI and UniProt summaries do not explicitly mention other associated genes, DIAPH3-AS1 may have functional relationships with nearby genes or those involved in similar biological pathways. Typically, genes in proximity can have regulatory interactions, and genes that regulate cytoskeletal dynamics and cellular signaling may also be of interest considering the role of DIAPH proteins in actin dynamics. Examples may include:
- **DIAPH3 (Diaphanous-related formins)**
- **DIAPH1**
- **DIAPH2**
- Other genes involved in cellular processes like cytoskeletal organization and cell signaling.

### 2. Aging and Age-related Diseases

While there is limited direct evidence available specifically linking DIAPH3-AS1 to aging or age-related diseases, some indirect associations can be considered:
- Antisense RNAs, like DIAPH3-AS1, may play roles in the regulation of genes associated with aging or stress responses.
- Alterations in gene expression patterns of long non-coding RNAs (lncRNAs), which may include DIAPH3-AS1, have been observed in various age-related diseases and conditions, including neurodegenerative diseases and cancers.
- Some research has indicated a connection between DIAPH-related signaling pathways and processes like cell migration (which can be critical in age-related tissue repair) and angiogenesis, which may be relevant in the context of diseases like Alzheimer's.

### 3. Drug Interactions

As of October 2023, there are no specific drugs or drug classes directly known to interact with **DIAPH3-AS1** documented in public databases. However, drugs affecting the signaling pathways associated with its functions (such as those targeting actin dynamics, similar to those targeting RhoGTPase signaling, e.g., cytochalasins) could indirectly relate to the gene’s role in cellular processes. Further research may clarify potential associations.

### 4. Pathways and Biological Processes

The DIAPH3-AS1 gene likely participates in several biological pathways and processes, such as:
- **Regulation of Actin Cytoskeleton**: Given its association with the DIAPH family of proteins, it may play a role in the dynamics of the actin cytoskeleton.
- **Cell Proliferation and Differentiation**: Potentially involved in processes that govern cell cycle regulation and cellular responses to external stimuli.
- **Cell Migration**: Important in wound healing and tissue repair mechanisms.
- **Signal Transduction**: May influence various signaling pathways involved in cellular responses.

In summary, DIAPH3-AS1 acts as an important player in gene regulatory networks potentially influencing cell function, and while its direct links to aging and diseases require further elucidation, it is associated with fundamental cellular processes that are vital for maintaining cellular health throughout the lifespan.