### GPD1L Gene Overview

**Gene Symbol**: GPD1L  
**Location**: Human Chromosome 3 (3p23)  
**Function**: The GPD1L gene encodes for glycerol-3-phosphate dehydrogenase 1-like protein, which is primarily involved in the conversion of sn-glycerol 3-phosphate to glycerone phosphate. It has significant roles in cardiac function through its association with sodium channels, specifically the voltage-gated sodium channel SCN5A.

### 1. Associated Genes
Beyond SCN5A, GPD1L has been linked or associated with other genes in studies related to cardiac function and disorders, including:
- **PKP2 (Plakophilin 2)**: Associated with arrhythmogenic right ventricular cardiomyopathy (ARVC).
- **ANK2 (Ankyrin 2)**: Involvement in cardiac signaling and rhythm regulation.
- **SCN10A and SCN1B**: Other sodium channel subunits often studied in relation to cardiac electrical activity and arrhythmias.

### 2. Aging and Age-Related Diseases
While direct associations between GPD1L and aging have not been extensively characterized, the role of GPD1L in cardiac health implies potential links to age-related conditions, especially:
- **Cardiovascular Diseases**: As cardiac function declines with age, any alterations in sodium channel regulation due to GPD1L mutations could exacerbate age-related cardiac issues.
- **Sudden Cardiac Death**: Given its involvement in syndromes like Brugada syndrome and SIDS, the gene is relevant in studies pertaining to age-related risk factors for sudden cardiac events.

### 3. Interactions with Drugs
Currently, specific drugs known to directly interact with GPD1L have not been extensively documented; however, indirectly, drugs that target the sodium channels, such as:
- **Class I antiarrhythmics**: These may influence the activity of SCN5A and thus, potentially have secondary effects via GPD1L interactions.
- **Cardiac glycosides**: Such as digoxin, which can impact sodium currents and might influence pathways involving GPD1L.

### 4. Pathways and Biological Processes
GPD1L is involved in several biological pathways and processes, including:
- **Sodium Ion Transport**: Regulating sodium influx in cardiomyocytes.
- **Cardiac Electrical Activity**: Influences cardiac action potential through sodium channel modulation.
- **Lipid Metabolism**: Its enzymatic function directly affects glycerolipid metabolism, feeding into broader metabolic pathways.
- **Regulation of Intracellular Glycerophosphate Levels**: Plays a significant role in cellular energy metabolism and signaling.

Overall, GPD1L is a critical gene in cardiac physiology with implications in various diseases, making it a significant focus of research in cardiology and genetics.