### TLNRD1 Gene Overview

**Gene Symbol:** TLNRD1  
**Description:** TLNRD1 (Talin-Related Protein 1) encodes a protein thought to have a role in oncogenic processes, particularly in human bladder cancer. It acts as an actin-binding protein involved in cell proliferation, migration, and invasion.

### 1. Associated Genes
While specific genes directly co-regulated or functionally associated with TLNRD1 may not be fully delineated in the summaries provided, potential interactions may involve:

- **MiR-574-3**: As a microRNA that regulates TLNRD1 expression.
- **Oncogenes and tumor suppressors**: Given its oncogenic role, TLNRD1 may interact with genes involved in the cell cycle and apoptosis, such as *TP53* and *MYC*.
- **Genes involved in cytoskeletal dynamics**: Other actin-binding proteins and those with similar functions, such as *Talin (TLN1)* and *Vinculin (VCL)*.

### 2. Aging and Age-related Diseases
Currently, there are no specific, well-documented associations between TLNRD1 and the aging process or age-related diseases in the literature. However, its role in cell proliferation, migration, and cancer suggests it may indirectly have implications in:
- **Cancer progression in older adults**: As incidence of many cancers increases with age, the function of TLNRD1 in malignancies might connect it to age-related tumorigenesis.
- **Cardiovascular diseases**: Its implication in mesoderm differentiation could suggest roles in heart development and repair, potentially linking it to age-related cardiovascular issues.

### 3. Drug Interactions
While specific drugs or drug classes that interact with TLNRD1 are not universally documented, its involvement in cancer suggests potential interactions with:
- **Chemotherapy agents**: Drugs that may target pathways involving cell proliferation (e.g., taxanes, antimetabolites).
- **mRNA inhibitors**: Targeting miR-574-3 could be relevant as it directly regulates TLNRD1 expression.

### 4. Pathways and Biological Processes
TLNRD1 is involved in several important cellular pathways and biological processes, including:

- **Cell adhesion and migration**: Modulating interactions between cells and extracellular matrices through actin dynamics.
- **Signal transduction pathways**: Potential involvement in pathways that regulate cell growth and differentiation.
- **Cancer-related pathways**: Particularly those involved in tumorigenesis, metastasis, and cellular response to stress.

### Summary
The TLNRD1 gene is of significant interest in cancer research, particularly bladder cancer, and its actin-binding properties suggest a broader role in cell dynamics. Its exact interactions, aging-related associations, and pharmacological connections merit further exploration to unravel the full biological significance of TLNRD1.