### NXF3 Gene Overview

**Gene Symbol:** NXF3  
**Gene Type:** Protein-coding

The NXF3 gene encodes a member of the nuclear RNA export factor family. This family is characterized by several important domains that are necessary for RNA export, including a noncanonical RNA-binding domain, leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain facilitating interaction with export proteins, and a ubiquitin-associated domain for nucleoporin interactions. Despite its role in RNA export, the specific encoded protein from NXF3 features a shortened LRR and ubiquitin-associated domain, leading to an inability to bind RNA via its RBD. NXF3 is localized in the nucleoplasm, yet does not associate with the nuclear envelope or nucleolus and is hypothesized to function as a tissue-specific mRNA export factor.

### 1. Associated Genes
While specific genes directly associated with NXF3 are not extensively detailed in the provided summaries, it is related to other nuclear RNA export factors such as:

- **NXF1**: Another member of the NXF family that plays a crucial role in mRNA export.
- **NXT1**: Works in heterodimerization processes with NXF3 for nuclear export functions.
- **RNAP2**: RNA polymerase II, which synthesizes mRNA and must be closely coordinated with RNA export.

Additional interactions may be noted through functional proteomics studies or gene expression analyses, though details might be limited in publicly available databases.

### 2. Aging and Age-Related Diseases
Current literature does not provide extensive direct evidence linking NXF3 to aging or age-related diseases. However, disruptions in mRNA export are thought to contribute to cellular senescence and the aging process due to altered gene expression. Aberrant regulation of nuclear RNA export factors is implicated in various neurodegenerative diseases, which are often associated with age. Researchers are investigating whether dysfunctional RNA export mechanisms involving genes like NXF3 may play a role in disorders such as:

- Alzheimer's Disease
- Amyotrophic Lateral Sclerosis (ALS)
- Other age-associated neurodegenerative disorders

These studies are ongoing and more targeted research is necessary to establish specific associations.

### 3. Drug Interactions
Currently, there are no widely recognized drugs or drug classes specifically interacting with the NXF3 gene explicitly listed in major pharmacological resources. However, as NXF3 is involved in mRNA export pathways, compounds that influence RNA polymerase activity, nucleocytoplasmic transport, or those targeting nuclear export processes (for instance, antiviral therapies or cancer treatments) may indirectly affect gene function.

### 4. Pathways and Biological Processes
The NXF3 gene is implicated in several important biological processes and pathways, including:

- **mRNA Export**: As a nuclear export factor, it is integral to the nuclear-cytoplasmic transport of mRNA, crucial for proper gene expression.
- **Gene Expression Regulation**: By facilitating mRNA transport, it plays a role in the regulation of gene expression.
- **Nucleocytoplasmic Transport**: Part of the broader category of processes that regulate the movement of molecules in and out of the nucleus.

### Conclusion
The NXF3 gene is an important component of the nuclear RNA export machinery, particularly in a tissue-specific context. Future research may reveal a deeper understanding of its implications in aging, disease, and potential therapeutic targets. As new findings emerge, particularly regarding associations with diseases and drug interactions, continued attention to this gene's role in cellular function and pathology will be paramount.