### Overview of KCNJ2-AS1 Gene

**Gene Symbol:** KCNJ2-AS1  
**Description:** KCNJ2-AS1 is a long non-coding RNA (lncRNA) that is known to be an antisense transcript associated with the KCNJ2 gene, which encodes a potassium ion channel subunit involved in cardiac repolarization.

### Other Genes Associated with KCNJ2-AS1

While the specific summaries from NCBI and UniProt may not detail the associated genes, KCNJ2-AS1 is likely linked to the following:

1. **KCNJ2:** The primary gene of interest, coding for the potassium ion channel and directly associated with cardiac electrophysiology.
2. **KCNQ1:** Another potassium channel gene implicated in cardiac function and arrhythmia.
3. **ANK3:** This gene is associated with neuronal excitability and cardiovascular health, showing potential links with potassium channels.
4. **CALM1:** This gene encodes calcium binding protein that can influence cardiac function and arrhythmias.

Additional interactions could be inferred through analyses of co-expression or in pathways involving potassium channels and cardiac function.

### Aging or Age-Related Disease Details

- **Cardiovascular Diseases:** Alterations in potassium ion channels, particularly KCNJ2, have been linked to arrhythmias and atrial fibrillation, which may have age-related implications.
- **Neurodegenerative Disorders:** KCNJ2 and its regulatory mechanisms could be involved in pathways affecting neuronal health and diseases that increase incidence with age, although direct links to KCNJ2-AS1 remain lesser-known.
- **Potential Role in Heart Aging:** Dysregulation of ion channels may contribute to age-related decline in cardiac function, with KCNJ2-AS1 possibly playing a regulatory role, though further research is needed for concrete connections.

### Drug or Drug Classes that Interact with KCNJ2-AS1

- **Antiarrhythmic Drugs:** Given its association with KCNJ2 and cardiac function, various antiarrhythmics (e.g., Class I and III drugs) may have indirect interactions through gene modulation or expression regulation.
- **Potassium Channel Blockers:** Medications like amiodarone that affect potassium channels might also impact KCNJ2 and its regulatory RNAs.

### Pathways and Biological Processes Involved

- **Ion Transport:** KCNJ2-AS1 is involved in processes that regulate potassium ion transport across membranes, crucial for maintaining cellular excitability.
- **Cardiac Action Potential Regulation:** The activity of KCNJ2 and its interaction with KCNJ2-AS1 plays an essential role in the repolarization phase of cardiac action potentials.
- **Cell Signaling Pathways:** The gene may participate in broader signal transduction pathways, especially those regulating cellular responses to electrophysiological stimuli.

In summary, KCNJ2-AS1 is crucial as a regulatory non-coding RNA associated with KCNJ2 gene function, primarily affecting potassium ion transport and cardiac health, with implications in aging and related diseases that warrant further investigation. Research continues to identify direct interactions and pathways to better understand its role in physiological and pathological processes.