### CT83 Gene Overview

**Gene Symbol:** CT83  
**Location:** Nucleus  
**Expression:** Specifically expressed in testis and by various cancer cell lines.

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### 1. Associated Genes

While the NCBI and UniProt summaries do not specify other directly associated genes, CT83 may be linked to other cancer-testis (CT) genes or genes involved in tumorigenesis and immune response, including:

- **MAGE (Melanoma Antigen Gene) Family**: Other CT antigens like MAGEA1, MAGEA3, etc.
- **NY-ESO-1**: Another CT antigen often expressed in various tumors.
- **SSX (Skeletal Muscle and Connective Tissue Antigen)**: Relevant in some cancers due to their tumor-specific expression.

These genes may participate in similar pathways or regulatory networks related to tumor immune recognition and testicular germ cell functions.

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### 2. Aging and Age-related Disease Associations

As of the latest updates until October 2023, specific literature linking CT83 to aging or age-related diseases is limited. However, considerations include:

- **Cancer Incidence with Age**: As CT83 is expressed in cancer cell lines, its expression may correlate with age-related malignancies. Studies show that the incidence of certain cancers increases with age, and CT antigens are often re-expressed in malignancies in older individuals.
- **Testicular Function**: CT83's expression in the testis implies potential roles in spermatogenesis, which can be affected by age, leading to issues related to fertility or the development of germ cell tumors.

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### 3. Drug Interactions

Currently, specific drugs or drug classes directly linked to CT83 have not been extensively documented. However, the broader category of immunotherapies that target CT antigens, or cancer therapies focused on tumor antigens for personalized medicine might be relevant. Potential agents affecting pathways in which CT83 is involved include:

- **Monoclonal Antibodies**: Therapies or clinical trials involving CT antigens may engage CT83.
- **Cancer Vaccines**: Experimental therapies targeting CT antigens to induce immune responses against cancer cells.

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### 4. Pathways and Biological Processes

CT83 is primarily associated with several biological processes, notably:

- **Immune Response**: Its expression pattern suggests a role in eliciting immune responses against tumors due to its limited expression in normal tissues besides the testis.
- **Oncogenesis**: As a cancer-testis antigen, it's potentially involved in processes related to tumorigenesis, allowing cancer cells to evade immune detection.
- **Germ Cell Development**: Involvement in processes related to male germ cell differentiation and spermatogenesis due to its expression in the testis.

### Summary

CT83 remains an important gene of interest, particularly in cancer research due to its unique expression patterns and potential roles in immune evasion within tumors. Further research may elucidate its exact mechanisms, additional interactions, and implications for treatment strategies, especially as they pertain to age-related changes in tumor biology.