### TBL1XR1-AS1 Gene Overview

**Gene Symbol:** TBL1XR1-AS1

TBL1XR1-AS1 is an antisense long non-coding RNA (lncRNA) gene that is associated with the TBL1XR1 gene, which encodes a protein involved in various cellular functions including transcriptional regulation and protein-protein interactions. As an antisense RNA, TBL1XR1-AS1 may have regulatory roles affecting the expression of TBL1XR1 and possibly other adjacent genes.

### 1. Associated Genes
While NCBI and UniProt may not specifically list associated genes, lncRNAs like TBL1XR1-AS1 often interact with multiple genetic elements. Based on functional studies of lncRNAs, TBL1XR1-AS1 may be associated with:

- **TBL1XR1** (target gene): The directly associated coding gene.
- **Other genes located proximally or distally on the same chromosome** that may be influenced in expression due to the regulatory effects of TBL1XR1-AS1.

### 2. Aging and Age-related Diseases
Research surrounding lncRNAs, including TBL1XR1-AS1, is ongoing. Here are some potential associations relevant to aging and age-related diseases:

- **Regulation of Senescence:** Emerging evidence suggests that lncRNAs can play roles in cellular senescence, a state associated with aging and age-related diseases.
- **Cancer:** Elevated levels of certain lncRNAs, potentially including TBL1XR1-AS1, have been implicated in oncogenesis and cancer progression, indicative of their involvement in age-related diseases where cancer incidence increases with age.
- **Metabolic Disorders:** Some lncRNAs are linked to metabolic regulation, and dysregulation may play a role in conditions such as type 2 diabetes and obesity, which are related to age.

### 3. Drug Interactions
As a long non-coding RNA, TBL1XR1-AS1 does not directly code for proteins, thus drugs do not typically target lncRNAs directly. However, the following contexts may apply:

- **Targeted Therapies/Drugs:** Some drugs may modulate the pathways regulated by the TBL1XR1 gene, which in turn may influence TBL1XR1-AS1 expression indirectly.
- **Epigenetic Modulators:** Compounds that affect the epigenome, such as histone deacetylase inhibitors, could potentially alter the expression of TBL1XR1-AS1.

No specific drug classes have been definitively linked to TBL1XR1-AS1.

### 4. Pathways and Biological Processes
TBL1XR1-AS1 is thought to be involved in various pathways and biological processes relevant to cancer biology and gene regulation, including:

- **Gene Regulation:** It potentially influences the transcriptional activity of TBL1XR1 and surrounding genes.
- **Nuclear Processes:** As many lncRNAs are involved in nuclear architecture and function, TBL1XR1-AS1 may play a role in nuclear organization.
- **Cell Proliferation and Differentiation:** Interactions with other molecular components may affect cell growth pathways, particularly in cancer.

### Conclusion
TBL1XR1-AS1 is a long non-coding RNA that may interact with various genetic and cellular pathways, particularly in relation to the functioning of TBL1XR1. Its involvement in aging and diseases, while not extensively characterized, connects it to broader biological themes including cancer and cellular regulation. Further research is warranted to elucidate its specific functions and therapeutic implications.