### TMEM105 Gene Overview

**Gene Symbol:** TMEM105  
**Location:** Human Chromosome 4  
**Predicted Function:** TMEM105 is predicted to be an integral component of the membrane, implied to play a role in cellular processes due to its localization and structural characteristics.

### 1. Associated Genes

While TMEM105 has not been extensively characterized in terms of interactions with specific genes, some genes and protein complexes that may be associated include:

- **TMEM family members:** Other genes in the TMEM (Transmembrane) family, such as TMEM106A, TMEM14A, may exhibit functional similarities and potential interaction due to structural domains.
- **Pathway-related genes:** Depending on pathways that TMEM105 might be involved in, there could be indirect associations with genes participating in similar biological processes or networks, such as those involved in membrane trafficking, cell adhesion, or immune responses.

### 2. Aging and Age-related Diseases

Currently, there is limited direct literature specifically linking TMEM105 to aging or age-related diseases. However, based on the function of other TMEM family members, potential associations might exist with:

- **Tissue integrity and homeostasis:** Altered TMEM functions can lead to cellular dysfunction, which is often a hallmark of aging.
- **Role in immune responses:** Aging is linked with immune senescence, and TNF signaling pathways can also regulate TMEM proteins.

Further research is needed to determine whether TMEM105 has specific interactions or effects via physiological changes related to aging or age-related pathologies such as Alzheimer's disease, cardiovascular diseases, or other chronic inflammatory conditions.

### 3. Drug Interactions

Presently, there are no specific drugs or drug classes universally known to directly interact with TMEM105. However, as part of continued research, drugs targeting pathways such as inflammation or cellular signaling that might involve TMEM proteins could cross-react or influence the expression levels or activity of TMEM105 indirectly. For example:

- **Immunomodulatory drugs:** Given its potential role in immune response, drugs like corticosteroids or other immunosuppressant medications could affect the activity of transmembrane proteins in immune cells.

### 4. Pathways and Biological Processes

TMEM105 may be involved in several biological processes, often dependent on its interactions within cellular systems:

- **Membrane trafficking:** Integral membrane proteins like TMEM105 likely play roles in vesicle formation, movement, or fusion processes.
- **Cell signaling pathways:** Depending on activators or interactions, TMEM105 might influence or be influenced by signaling cascades, such as those related to inflammation or cell cycle.
- **Cell adhesion and migration:** As it is a membrane-associated protein, it might also be implicated in processes governing cell-to-cell interactions or migration pathways.

### Conclusion

The TMEM105 gene is an integral membrane protein with potential implications in several biological processes. Research into its function, particularly regarding associations with aging, age-related diseases, and interactions with pharmacological agents is ongoing, and results may emerge as more studies are conducted in this area. Current literature exhibits a need for further investigation to better understand the functional significance and clinical relevance of TMEM105.