### Overview of GSTM2 Gene

**Gene Symbol:** GSTM2  
**Location:** Chromosome 1p13.3  
**Gene Family:** Glutathione S-transferase (GST) mu class  
**Function:** Detoxification of electrophilic compounds through conjugation with glutathione  

### 1. Associated Genes
GSTM2 is part of a larger gene cluster on chromosome 1 that includes several other members of the mu class of glutathione S-transferases. Notable associated genes include:
- **GSTM1:** Another member of the mu class that is implicated in detoxification processes.
- **GSTM3:** Also part of the mu class, which plays similar roles in detoxifying reactive compounds.
- **GSTM5:** Another gene in the same family with functions pertaining to xenobiotic metabolism.

### 2. Aging and Age-Related Diseases
Various studies have indicated that polymorphisms in GSTM2 and associated GST genes may influence susceptibility to age-related diseases such as:
- **Cancer:** Variations in GSTM2 may affect the metabolism of carcinogens, potentially impacting the risk of developing various types of cancer, particularly those associated with aging.
- **Neurodegenerative Disorders:** Some studies have suggested a link between GST polymorphisms, including those of GSTM2, and the risk of diseases like Alzheimer's and Parkinson's, given their role in detoxifying oxidative stress-inducing agents.

### 3. Drug Interactions
GSTM2 is known to interact with a variety of drugs as well as drug classes, including:
- **Anti-cancer drugs:** GST enzymes, including GSTM2, can affect the metabolism of chemotherapeutic agents, which may influence drug efficacy and toxicity.
- **Non-steroidal anti-inflammatory drugs (NSAIDs):** GSTM2 may play a role in the metabolism of these drugs, potentially affecting their side effects.
- **Antidepressants and analgesics:** There is evidence that GSTM2 can influence the pharmacokinetics of these medications.

### 4. Pathways and Biological Processes
GSTM2 is involved in several key biological pathways and processes:
- **Detoxification pathway:** It plays a critical role in the detoxification of drugs, pollutants, and endogenous compounds by conjugating reactive electrophiles with glutathione.
- **Oxidative stress response:** GSTM2 contributes to the cellular defense against oxidative stress, protecting against damage caused by reactive oxygen species (ROS).
- **Biosynthesis of lipid mediators:** GSTM2 has been implicated in the metabolism of hepoxilins, which are involved in various cellular signaling pathways, including inflammation.

In summary, the GSTM2 gene plays a significant role in detoxifying harmful compounds and protecting the body from oxidative stress, with implications for aging and susceptibility to various diseases, as well as interactions with a range of pharmaceuticals. Its paralogs and polymorphisms contribute to an individual's response to toxins and medication metabolism.