### SLC52A2 Gene Overview

**Gene Symbol**: SLC52A2  
**Located On**: Chromosome 20

### Summary
The SLC52A2 gene encodes a membrane protein that is part of the riboflavin transporter family. It is crucial for the intestinal absorption of riboflavin (vitamin B2), which is essential for various biochemical pathways as it is converted into key coenzymes like flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Unlike other members of the riboflavin transporter gene family, SLC52A2 exhibits higher expression in the brain than in the small intestine. Mutations in this gene have been linked to Brown-Vialetto-Van Laere syndrome 2, associated with symptoms affecting the nervous system.

### 1. Associated Genes
While SLC52A2 itself is primarily characterized by its role as a riboflavin transporter, it, like other transporter proteins, may show interactions or functional associations with other genes involved in nutrient transport or metabolism, including:

- **SLC52A1**: Another member of the riboflavin transporter family that is involved in riboflavin uptake, though located on chromosome 17.
- **SLC22A5 (OCTN2)**: Involved in the transport of carnitine, which is linked to energy metabolism and may also be influenced by riboflavin status.
- **ABCB1**: While this gene encodes an efflux transporter, it may interact in the context of drug metabolism and absorption influenced by riboflavin levels.

### 2. Aging and Age-related Diseases
There is limited direct evidence linking SLC52A2 to aging or age-related diseases. However, since riboflavin plays a role in cellular metabolism and energy production, deficiencies in riboflavin transport could potentially affect aging-related health issues, such as mitochondrial dysfunction and neurodegenerative diseases, particularly since SLC52A2 is expressed in the brain.

Research on riboflavin as an antioxidant might also offer insights into its role in aging, as it helps in reducing oxidative stress. However, further studies are needed to elucidate any specific direct roles SLC52A2 might play in aging or related diseases.

### 3. Drug Interactions
While there may not be direct pharmacological agents known specifically to target or interact with the SLC52A2 gene, compounds or drugs involved in the regulation of riboflavin levels may be indirectly related. Some considerations include:

- **Riboflavin Supplements**: As a direct interaction since supplementation could theoretically alleviate effects of SLC52A2 mutations.
- **Drugs affecting nutrient absorption**: Any medication that alters gastrointestinal function may indirectly affect riboflavin uptake mediated by SLC52A2.

### 4. Pathways and Biological Processes
SLC52A2 is involved in pathways related to:

- **Vitamin B2 Metabolism**: Uptake of riboflavin for conversion into FMN and FAD.
- **Oxidative Phosphorylation**: Riboflavin coenzymes are vital for energy production in mitochondria.
- **Metabolism of Carbohydrates, Lipids, and Proteins**: Through its role in supplying coenzymes needed for various metabolic pathways.
- **Neurotransmitter Metabolism**: Due to its expression in brain tissue, affecting neurotransmitter synthesis and metabolism.

Overall, SLC52A2 is critical for nutrient uptake and plays a role in several metabolic processes that are essential for cellular function, particularly in the nervous system. Further research could shed more light on its full range of implications in health and disease.