### PI4KA Gene Overview

**Gene Symbol**: PI4KA  
**Gene Description**: The PI4KA gene encodes a phosphatidylinositol (PI) 4-kinase, playing a crucial role in lipid metabolism and signaling pathways. It catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a key signaling molecule.

### 1. Associated Genes
While the specific mentions of associated genes might not be present in the provided summaries, PI4KA is generally associated with several other genes involved in phosphoinositide metabolism and signaling, including:

- **PTEN**: A phosphatase that regulates lipid signaling and is involved in the same pathways affecting PI(4,5)P2.
- **PIK3CA**: Part of the phosphoinositide 3-kinase (PI3K) family, which is involved in downstream signaling from PI(4,5)P2.
- **ITGB3**: A gene encoding the integrin beta-3 subunit which can interact with PI(4,5)P2 in various cellular processes.
- **PLCG1**: Phospholipase C gamma 1, which is activated by receptor engagement and generates inositol-1,4,5-trisphosphate from PI(4,5)P2.

### 2. Aging and Age-Related Diseases
Research indicates that disturbances in phosphoinositide signaling pathways, including those involving PI4KA, can contribute to age-related diseases, particularly neurodegenerative disorders like Alzheimer’s disease. Dysregulation in PI(4,5)P2 levels and its downstream signaling might affect synaptic plasticity and neuronal health. While direct links between PI4KA and aging may not be fully established, its involvement in critical signaling pathways implies potential roles in:

- Neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s)
- Metabolic syndromes
- Altered cellular signaling affecting stem cell function and regeneration

### 3. Drug Interactions
While detailed pharmacological data specific to PI4KA may not be comprehensively documented, the PI4K family and its pathways are of increasing interest in drug development. There are ongoing studies targeting PI4K for:

- **Anti-cancer agents**: Since PI4K pathways are implicated in tumorigenesis and cancer progression.
- **Neuroprotective drugs**: Targeting pathways associated with neurodegeneration.
- **Antiviral therapies**: Certain inhibitors of PI4K may be investigated due to their effects on viral replication.

### 4. Pathways and Biological Processes
PI4KA is involved in various critical cellular processes and pathways, including:

- **Phosphoinositide signaling pathways**: Central to various cellular signaling processes.
- **Endocytosis and vesicular transport**: PI(4,5)P2 plays important roles in the function of clathrin-coated pits and endocytosis.
- **Regulation of cell proliferation and differentiation**: Through its role in PI(4,5)P2 synthesis and downstream signaling pathways.
- **Calcium signaling**: PI(4,5)P2 is a precursor for inositol trisphosphates (IP3), which release intracellular calcium.

### Summary
The PI4KA gene is integral to the metabolism of phosphoinositides and plays a significant role in cell signaling pathways governing a variety of biological functions. It has potential implications in aging and age-related diseases, primarily due to its influence on neuronal health and cellular signaling processes. Its interactions with other genes and potential drug targets highlight its importance in both health and disease contexts. Further research is essential for elucidating its complete roles and therapeutic potentials.