### KLHL36 Gene Overview

**Gene Symbol**: KLHL36  
**Genomic Location**: Chromosome 17  
**Protein Summary**: KLHL36 encodes a protein that is predicted to function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex, facilitating the ubiquitination and proteasomal degradation of target proteins.

#### 1. Associated Genes
While specific gene associations for KLHL36 may not be extensively detailed in standard annotations, it is known to interact with several other cullin proteins and components involved in ubiquitin-proteasome pathways, including:
- **CUL3** (Cullin 3)
- **RBX1** (RING-box protein 1)
- **GSK3B** (Glycogen synthase kinase 3 beta)
- Other cullin-family proteins and multiple SKP1, BTB-domain containing proteins, and various substrates involved in signal transduction pathways.

#### 2. Aging and Age-Related Diseases
Currently, there is limited direct evidence linking KLHL36 to aging or specific age-related diseases in the literature. However, since KLHL36 is involved in protein ubiquitination, which is essential for regulating the degradation of damaged or misfolded proteins, alterations in its function could contribute to cellular stress responses and the accumulation of such proteins. This dysfunction is commonly observed in age-related diseases such as:
- Neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s)
- Cancer (where the deregulation of protein degradation pathways can lead to tumorigenesis)

Further research is required to elucidate specific roles of KLHL36 in the context of aging.

#### 3. Drug Interactions
Currently, there are no direct drug interactions documented specifically with KLHL36. However, drugs targeting the ubiquitin-proteasome system, such as:
- **Proteasome inhibitors** (e.g., Bortezomib)
may indirectly affect the pathways in which KLHL36 participates, given its role in ubiquitination processes. Future investigations might reveal more clinically relevant interactions.

#### 4. Pathways and Biological Processes
KLHL36 is primarily linked with the following biological processes and pathways:
- **Ubiquitin-Proteasome Pathway**: Involvement in the tagging of proteins for degradation.
- **Protein Catabolic Process**: Related to the breakdown of proteins within the cell.
- **Response to Cellular Stress**: Via the regulation of protein turnover and quality control processes.
- **Cell Cycle Regulation**: Potential impact on cell cycle progression through the degradation of regulatory proteins.

KLHL36 may also contribute to various signaling pathways associated with apoptosis and cell survival, though specific pathway assignments require more focused studies.

### Conclusion
KLHL36 is a potentially important gene in cellular protein regulation through its role in ubiquitination. Further research could provide greater insight into its interactions with aging, age-related diseases, and therapeutic implications.