### PPFIBP2 Gene Overview

**Gene Symbol**: PPFIBP2  
**Gene Description**: PPFIBP2 encodes a protein that is part of the liprin family, specifically a beta liprin. This protein interacts with LAR protein-tyrosine phosphatases and plays a crucial role in axon guidance and the development of neuronal synapses by recruiting these phosphatases to the plasma membrane. The gene exhibits alternative splicing, resulting in multiple isoforms.

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### 1. Associated Genes

PPFIBP2 is known to interact with various other genes, some of which prominently include:

- **LAR (Leukocyte common antigen-related phosphatase)**: A key interaction in the context of synaptic development and function.
- **PTPδ (Protein Tyrosine Phosphatase Delta)**: Involved in neuronal signaling and may interact in synapse formation.
- **LAR PTPS (e.g., PTPRS)**: Related phosphatases that might interact with PPFIBP2 in signaling pathways underlying synaptic function and development.

### 2. Aging and Age-related Diseases

Although specific studies directly linking PPFIBP2 to aging or age-related diseases may be limited, proteins involved in axon guidance and neuronal synapse development are often critical in the context of neurodegenerative disorders. Altered function of synapses is implicated in conditions such as:

- **Alzheimer's Disease**: Synaptic failure and cognitive decline are key features, and PPFIBP2 may indirectly influence these processes through its role in axon guidance.
- **Age-related cognitive decline**: Proteins essential for proper neuronal function can be affected by aging, suggesting that PPFIBP2 could be an area of interest in studies investigating age-related cognitive impairments.

### 3. Drug Interactions

As of the latest data available, specific drugs or drug classes that directly interact with PPFIBP2 are not well-characterized. However, drugs that affect neuronal signaling pathways, such as certain antipsychotics or cognitive enhancers targeting synaptic function, might indirectly modulate pathways involving PPFIBP2. Additional research is necessary to explore this area thoroughly.

### 4. Pathways and Biological Processes

**Biological Processes**:
- **Neuronal Development**: PPFIBP2 is crucial for proper development and maturation of neurons.
- **Axon Guidance**: It assists in directing growing axons to their appropriate targets.
- **Synapse Formation**: Involved in the assembly and regulation of presynaptic complexes, facilitating synaptic transmission.

**Pathways**:
- **Neuroactive Ligand-Receptor Interaction**: Through its involvement in synaptic signaling, PPFIBP2 may play a role in signaling cascades initiated by neuroactive ligands.
- **Focal Adhesion Regulation**: PPFIBP2 may regulate focal adhesion disassembly, impacting cell migration and adhesion dynamics.

### Conclusion

In summary, the PPFIBP2 gene encodes a protein that plays a significant role in neuronal development, particularly concerning axon guidance and synapse formation. It is associated with key interacting genes and pathways relevant to neuronal signaling. Further investigation into its role in aging and associated therapies may offer additional insights into its biological significance.