### CEP350 Gene Overview

**Gene Symbol**: CEP350  
**Location**: The gene is located on chromosome 4 in humans, spanning approximately 80 kb.  
**Protein Product**: The CEP350 gene encodes a large protein primarily localized at the centrosome, characterized by the presence of a CAP-Gly domain involved in interactions with microtubules.

### 1. Associated Genes
In addition to its interactions with SASS6 and CENPJ for centriole growth, CEP350 might be associated with other genes and proteins involved in centrosomal function and integrity. Notably, these may include:

- **TUBG1**: A gene encoding the gamma-tubulin complex component that plays a key role in microtubule nucleation.
- **KIFC1**: Codes for a kinesin family member involved in microtubule dynamics and centrosomal function.
- **PCNT**: Codes for pericentrin, a centrosome-associated protein essential for microtubule organization.
- **AURKA**: Aurora kinase A involved in mitotic regulation, which interacts with centrosomes.

### 2. Aging and Age-Related Diseases
Research has suggested potential associations between CEP350 and several aspects of aging and age-related diseases:

- **Cellular Senescence**: Dysfunction of centrosomal proteins can lead to altered cellular senescence, which is a hallmark of aging.
- **Neurodegenerative Disorders**: Abnormalities in microtubule dynamics and centrosome function linked to CEP350 may be implicated in neurodegenerative diseases such as Alzheimer’s disease.
- **Cancer**: Given its role in microtubule organization and cell division, abnormal expression or function of CEP350 may contribute to tumorigenesis and cancer progression. 

### 3. Drug Interactions
Although specific drugs targeting CEP350 are not extensively documented, the gene's involvement in centrosomal stability and microtubule dynamics suggests potential interactions with drug classes that influence:

- **Microtubule inhibitors**: Such as taxanes (e.g., Paclitaxel), which stabilize microtubules.
- **Aurora kinase inhibitors**: These might impact cellular pathways involving CEP350.

Further studies may clarify whether targeting pathways involving CEP350 could impact therapeutic strategies in cancers or related disorders.

### 4. Pathways and Biological Processes
CEP350 is involved in several important biological processes and pathways:

- **Microtubule Organization**: Essential for the anchoring and stabilization of microtubules at the centrosome, playing a critical role in the formation of the mitotic spindle during cell division.
- **Centrosome Assembly**: Involved in centriole biogenesis and the maintenance of centrosomal integrity.
- **Ciliogenesis**: Plays a role in the formation and function of cilia, which are important for various signaling pathways and cell motility.
- **Regulation of Nuclear Hormone Receptors**: Particularly in modulating the activity of PPARA (peroxisome proliferator-activated receptor alpha).

Collectively, the functions of CEP350 establish its importance in maintaining cellular integrity, division, and response to various cellular signals, linking it to potential therapeutic targets in diseases related to centrosomal dysfunction. Further research will help in elucidating the precise role of CEP350 and its clinical relevance.