### KLHL12 Gene Overview
**Gene Symbol:** KLHL12  
**Function:** KLHL12 encodes a member of the kelch-like protein family, playing a critical role in substrate specificity for the Cullin-3 ubiquitin ligase complex, regulating various biological processes through ubiquitylation.

### 1. Associated Genes
While the NCBI and UniProt summaries do not explicitly list other genes associated with KLHL12, it is known to interact with:
- **DVL3 (Dishevelled segment polarity protein 3):** Involved in the Wnt signaling pathway and negatively regulated by KLHL12.
- **SEC31A/B (SEC31 homolog A/B):** Part of the COPII vesicle coating complex which is regulated for ER-Golgi transport.
- **PEF1 (Peptidylprolyl isomerase F1):** Involved in neural crest specification and has a role in KLHL12 complex interactions.
- **PDCD6 (Programmed cell death 6):** Can form a complex with KLHL12 in response to calcium signaling.
- **DRD4 (Dopamine receptor D4):** Regulated by KLHL12 through ubiquitination.
  
### 2. Aging and Age-Related Diseases
- **Autoimmune Disease:** KLHL12 has been identified as an autoantigen in Sjögren's syndrome, which can have age-related prevalence as autoimmune diseases often increase in older populations.
- **Liver Disease:** As a potential biomarker in primary biliary cirrhosis (an age-related liver disease), KLHL12 could be linked to mechanisms of liver aging and pathogenesis of diseases that manifest with age.

### 3. Known Drug or Drug Classes
Currently, there is limited direct evidence regarding specific drugs or drug classes that interact with KLHL12. However, insights can be drawn from its role in the ubiquitin-proteasome system, suggesting interactions with compounds that modulate proteasomal degradation, such as:
- **Proteasome Inhibitors:** These can influence the broader processes involving the ubiquitin-proteasome system in which KLHL12 is involved.
- **Wnt Pathway Modulators:** Given KLHL12's negative regulation of Wnt signaling, drugs affecting this pathway could have indirect effects.

### 4. Pathways and Biological Processes
**Key Involvement:**
- **Ubiquitin-Mediated Proteolysis:** KLHL12 is integral in the ubiquitination process, impacting protein degradation.
- **Wnt Signaling Pathway:** Acts as a negative regulator, involved in the modulation of pathways crucial for development and cellular differentiation.
- **ER-Golgi Transport:** By regulating COPII vesicle coat size, KLHL12 is key in protein trafficking between the endoplasmic reticulum and Golgi apparatus, affecting transport of collagen.
- **Neural Crest Specification:** Involved in embryonic development processes and responses to calcium signaling, linking cellular mechanisms to developmental biology.

### Conclusion
KLHL12 is a versatile gene with significant implications in various cellular processes, disease mechanisms, especially autoimmune conditions, and potential links to age-related diseases. Its interactions with other proteins position it as a valuable target for understanding the role of ubiquitylation in health and disease.