### GPR83 Gene Overview

**Gene Symbol**: GPR83  
**Type**: G-protein coupled receptor (GPCR)  
**Location**: Cilium  
**Known Functions**: 
- Acts as a receptor for the neuropeptide PEN, derived from the proSAAS precursor protein (encoded by PCSK1N).
- Involved in neuropeptide signaling pathways.
- Plays a regulatory role in food intake and body weight management.
- May influence anxiety-related behaviors.

### 1. Associated Genes
GPR83 has known associations with several other genes and proteins, including:
- **PCSK1N (ProSAAS)**: This gene encodes the precursor protein from which PEN is derived, directly linking GPR83 to the processing and signaling of neuropeptides.
- **LEPR (Leptin Receptor)**: Involved in energy regulation and may interact with neuropeptides and pathways affected by GPR83.
- **CRH (Corticotropin-Releasing Hormone)**: This gene plays a significant role in stress responses, which may be co-regulated in pathways involving GPR83.
- Other GPCRs and neuropeptide receptor genes may also be functionally related to GPR83 but the specific associations vary with different contexts.

### 2. Aging and Age-Related Diseases
While direct associations between GPR83 and aging or age-related diseases are still being explored, some relevant observations include:
- **Neurodegeneration**: Given that GPR83 is implicated in neuropeptide signaling, which can impact neural health, alterations in its expression or function might influence neurodegenerative processes.
- **Stress Responses**: Since GPR83 shows involvement in anxiety-related behaviors, dysregulation may be relevant to age-related anxiety disorders or depression, commonly observed in older populations.
- **Metabolic Regulation**: Changes in food intake and body weight regulation mediated by GPR83 may contribute to obesity and metabolic dysfunction, both of which can influence aging.

### 3. Drug Interactions
Although specific drugs are not typically listed in major databases concerning GPR83, the GPCR family often interacts with a wide range of pharmacological agents:
- **Antidepressants**: Some antidepressants that affect serotonin and norepinephrine systems may indirectly influence GPR83-related pathways.
- **Antipsychotics**: Given their interaction with neuropeptide signaling, certain antipsychotic drugs could modulate the effects of GPR83.
- **Leptin and insulin sensitizers**: Drugs that enhance metabolic processes regulated by neuropeptide signaling may also affect or target pathways involving GPR83.

### 4. Pathways and Biological Processes
GPR83 is involved in several key biological processes:
- **Neuropeptide Signaling Pathway**: As a receptor for PEN, GPR83 influences signaling mechanisms critical for neural communication and regulation.
- **Regulation of Food Intake and Energy Homeostasis**: GPR83 plays a role in the mechanisms that govern appetite and weight management.
- **Stress Response Mediation**: Potential involvement in pathways governing stress, anxiety, and emotional behaviors.
- **Involvement in Inflammatory Response**: GPCRs often engage in regulating inflammation, suggesting GPR83 could have a role in modulating inflammatory processes.

### Conclusion
The GPR83 gene is crucial in neuropeptide signaling and is involved in several physiological responses and pathways. Its associations with food intake, weight regulation, and potential influences on physiological responses to stress and anxiety make it an important focus for research, particularly in contexts related to aging and metabolic disorders. Understanding its interactions with other genes and pathways can pave the way for targeted therapeutic strategies in related conditions.