### ENTPD3 Gene Overview

**Gene Symbol**: ENTPD3  
**Location**: Human genome, located on chromosome 1  
**Function**: ENTPD3 encodes a plasma membrane-bound E-type nucleotidase that hydrolyzes extracellular nucleotides, particularly ATP, and plays a role in nucleotide metabolism and purinergic signaling. The enzyme preferentially hydrolyzes ATP over ADP, suggesting its importance in regulating ATP levels in the extracellular space.

### 1. Associated Genes
While specific gene associations may not be exhaustively described in public databases, ENTPD3 has been noted to interact with other genes involved in nucleotide metabolism and purinergic signaling, including:
- **ENTPD1 (NTPDase1)**: Another ecto-nucleotide triphosphate diphosphohydrolase involved in the hydrolysis of nucleotides.
- **ABCC1 (Multidrug Resistance Protein 1)**: Involved in ATP transport and may exhibit functional relations to nucleotide homeostasis.
- **P2RY receptors** (such as **P2RY1**, **P2RY2**): Purinergic receptors that mediate signals triggered by nucleotides like ADP and ATP.

### 2. Aging and Age-Related Disease Associations
Research suggests that extracellular ATP and purinergic signaling can influence cellular aging and modulate age-related processes. Although direct associations of ENTPD3 with aging are not extensively documented, deregulation of ATP levels due to compromised ENTPD3 function may contribute to age-related diseases such as:
- Neurodegenerative diseases
- Cardiovascular disorders
- Cancer

Altered ATP metabolism can influence cellular survival, apoptosis, and inflammatory processes often observed in aging.

### 3. Drug Interactions
Specific drugs or drug classes that interact with ENTPD3 are not typically highlighted in literature; however, potential interactions may include:
- **Purinergic signaling inhibitors**: These may target enzymes involved in nucleotide metabolism and could influence ENTPD3 activity.
- **Nonsteroidal anti-inflammatory drugs (NSAIDs)**: These may impact purinergic signaling pathways indirectly through modulation of inflammation.

The therapeutic targeting of purinergic signaling pathways is an emerging area in pharmacology, which may indirectly involve the modulation of ENTPD3 activity.

### 4. Pathways and Biological Processes
ENTPD3 is involved in several biological processes and pathways, including:
- **Purine metabolism**: Hydrolysis of ATP and other nucleotides, affecting energy homeostasis.
- **ATP metabolic process**: Key role in regulating levels of ATP and ADP in the extracellular environment.
- **Signal transduction**: Serves as a purinergic receptor signaling facilitator through ATP hydrolysis.
- **Inflammation**: Participation in modulating inflammatory responses via ATP signaling.
- **Cell proliferation and apoptosis**: Influencing cellular survival and death pathways through the manipulation of extracellular ATP levels.

**Key Pathways**:
- **Purinergic signaling pathway** 
- **Metabolism of nucleotides** 

Overall, ENTPD3 plays a crucial role in regulating extracellular nucleotide levels, influencing numerous biological processes and potentially impacting longevity and disease states. Further research may elucidate specific therapeutic opportunities targeting this gene.