### KDM2B Gene Overview

**Gene Symbol:** KDM2B  
**Location:** Chromosome 19  
**Gene Type:** Protein Coding  
**Protein Class:** F-box family, Histone demethylase  

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#### 1. Associated Genes

While the summaries provided do not specifically enumerate associated genes, KDM2B is known to interact with several proteins and regulatory networks:

- **SKP1**: A key component of the SCF E3 ubiquitin ligase complex in which KDM2B acts as the substrate-recognition component.
- **Cul1**: Part of the SCF complex, linked to cell cycle regulation.
- **SETDB1**: A histone methyltransferase that may have antagonistic roles to KDM2B in the regulation of histone methylation.
- **MYC**: KDM2B is known to repress MYC target genes, which are important in cell growth and proliferation.

Additionally, other histone demethylases in the JmjC domain family may also have functional relationships or pathways shared with KDM2B.

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#### 2. Aging and Age-Related Diseases

KDM2B has implications in several aging-related processes:

- **Cell Proliferation**: As KDM2B can repress ribosomal RNA gene transcription, its regulation is linked to cellular aging and senescence, contributing to reduced cell growth.
- **Tumorigenesis**: Dysregulation of KDM2B has been observed in various cancers, such as breast cancer and other malignancies where it may contribute to the progression and maintenance of cancer stem cells, which are often linked to aging.
- **Neurodegenerative Diseases**: Alterations in histone demethylation have been implicated in the pathology of neurodegenerative disorders, including Alzheimer's disease, suggesting that KDM2B might play a role in these age-related diseases.

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#### 3. Drug Interactions

Currently, there are no specific drugs directly targeting KDM2B itself; however, this gene is implicated in several signaling pathways that are influenced by broad classes of drugs:

- **Histone Deacetylase Inhibitors (HDACi)**: Compounds that affect chromatin remodeling could indirectly influence KDM2B activity through modifications on histones that interact with it.
- **Cancer Therapeutics**: Drugs targeting pathways involving MYC or the SCF ubiquitin ligase complex may have indirect effects on KDM2B expression or function.

Ongoing research may lead to the identification of specific inhibitors targeting the demethylase activity of KDM2B or its role within the E3 ligase complex.

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#### 4. Pathways and Biological Processes

KDM2B is involved in several biological processes, including:

- **Histone Modification**: It participates in chromatin remodeling through demethylation of specific lysine residues on histones, primarily H3 'Lys-4' and H3 'Lys-36'.
- **Gene Transcription Regulation**: KDM2B binds to and represses the transcription of rRNA genes, thus playing a role in ribosome biogenesis.
- **Ubiquitination Pathways**: As part of the SCF-type E3 ubiquitin ligase complex, it contributes to substrate recognition and protein degradation pathways.
- **Cell Cycle Regulation**: Influencing genes associated with cellular proliferation, it plays a role in cell cycle progression and potentially impacts cancer development.

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This comprehensive overview illustrates KDM2B's multifaceted role in cell biology, links to disease, and its regulatory mechanisms influencing gene expression and chromatin structure. Further research continues to uncover the complexities of its functions and interactions within cellular contexts.