### SNORD113-3 Gene Overview

**Gene Symbol**: SNORD113-3

**Description**: SNORD113-3 is a small nucleolar RNA (snoRNA) gene that belongs to the C/D box snoRNA class. It is primarily involved in guiding the methylation of rRNA, leading to modifications crucial for ribosome biogenesis and function.

### Associated Genes

As of the last update, specific additional genes directly associated with SNORD113-3 may include other snoRNA genes or genes involved in the processing of rRNA. Examples could be:

- **RPLP0** (ribosomal protein, large, P0): A key component of the ribosomal machinery.
- **RRP1B** (rRNA processing 1B): Involved in ribosomal RNA processing and modification.

Furthermore, some studies indicate associations with genes related to RNA modification pathways.

### Aging and Age-Related Diseases

- **Aging**: The function of snoRNAs, including SNORD113-3, has been implicated in cellular aging processes due to their roles in rRNA modification and ribosome function. Impaired ribosome biogenesis can lead to cellular senescence, which is a notable characteristic of aging.
- **Age-Related Diseases**: While specific direct correlations of SNORD113-3 with age-related diseases may not be conclusively established, dysregulation of snoRNAs has been linked to conditions such as cancer and neurodegenerative diseases, which are closely associated with aging.

### Drug Interactions

Currently, there are no specific drugs or drug classes known to directly interact with SNORD113-3. However, it is important to note that treatments that affect overall RNA processing or ribosome biogenesis could indirectly impact the function of this snoRNA.

### Pathways and Biological Processes

SNORD113-3 is implicated in several biological processes and pathways:

1. **Ribosome Biogenesis**: It plays a role in the processing and modification of ribosomal RNAs, which is essential for the assembly of ribosomes.
2. **rRNA Methylation**: The primary known function of SNORD113-3 involves the guide activity for 2'-O-methylation of specific rRNA residues, which is a critical post-transcriptional modification.
3. **Cell Proliferation**: By facilitating proper ribosome function, SNORD113-3 may contribute to cellular growth and proliferation.

### Summary

SNORD113-3 is a small nucleolar RNA involved in ribosome biogenesis through guiding rRNA methylation. While its relationships with other genes, pathways, aging, and disease conditions are pertinent, further research is essential for a deeper understanding of its implications in health and disease.