### Overview of the PPIL1 Gene

**Gene Symbol**: PPIL1  
**Location**: Chromosome 2 (2q31.1)  
**Function**: The PPIL1 gene encodes a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). These proteins are involved in the folding of proteins, catalyzing the cis-trans isomerization of proline imidic peptide bonds in polypeptides, and play roles in various cellular processes, including pre-mRNA splicing as a component of the spliceosome.

### Additional Information

1. **Associated Genes**:
   - **CDC40/PRP17**: Known to be involved in pre-mRNA splicing, where PPIL1 catalyzes the prolyl peptide bond isomerization.
   - Other spliceosome components and genes involved in RNA processing may also show interactions, but specific interactions can depend on experimental contexts and conditions.

2. **Aging and Age-Related Diseases**:
   - Although not extensively studied, cyclophilin family members, including PPIL1, are implicated in cellular processes that could be linked to aging, such as protein homeostasis and transcriptional regulation.
   - Dysregulation of splicing factors has been observed in age-related diseases, including neurodegenerative disorders and cancers. The role of PPIL1 in embryonic brain development may have implications for age-related cognitive decline and neurodevelopmental diseases.

3. **Drug Interactions**:
   - **Cyclosporin A**: A well-known immunosuppressant drug that interacts with cyclophilins, including PPIL1, by inhibiting their isomerase activity.
   - **Drugs targeting splicing processes**: While direct drugs for PPIL1 are not well-characterized, therapies that modulate splicing might indirectly affect the function of PPIL1 due to its role in the spliceosome.
   - Various other drugs may interact with cyclophilin family proteins in general, which can include those developed for antiviral and anti-inflammatory purposes.

4. **Pathways and Biological Processes**:
   - **Spliceosomal Assembly and Function**: Involved in the assembly and function of the spliceosome, facilitating pre-mRNA splicing.
   - **Protein Folding**: Plays a crucial role in the proper folding of proteins, significantly contributing to cellular protein homeostasis.
   - **Embryonic Development**: Involvement in embryonic brain development suggests a role in neural differentiation and patterning.
   - **Response to Stress**: Like other cyclophilins, PPIL1 may play a role in cellular response mechanisms to various stresses, including oxidative stress.

### Summary
The PPIL1 gene encodes a pivotal protein for pre-mRNA splicing and protein folding. Its role within the spliceosome may connect it to various neurodevelopmental processes and potentially link it to age-related conditions through splicing dysregulation. Moreover, while PPIL1 interacts with some known drugs like cyclosporin A, the broader implications of cyclophilins and drug interactions warrant further exploration in clinical contexts.