### NAA15 Gene Summary

#### Gene Details
- **Gene Symbol**: NAA15
- **Function**: The NAA15 gene encodes an auxiliary subunit of the N-terminal acetyltransferase A (NatA) complex, which catalyzes the acetylation of the N-terminal amino group of nascent polypeptides. This post-translational modification is crucial for various cellular functions, including protein stability, localization, and interaction with other biomolecules.

### 1. Associated Genes
While the gene summaries primarily focus on NAA15 without listing many specific associated genes, NAA15 is known to interact with several proteins including:
- **NAT1 (N-terminal acetyltransferase 1)**: This is part of the NatA complex that includes NAA15, central to the acetylation of protein substrates.
- **XRCC5 (Ku80)** and **XRCC6 (Ku70)**: These proteins are known for their role in DNA repair and have been mentioned to co-operate with NAA15 in transcriptional regulation.
  
Other genes potentially associated with NAA15 through biological pathways or protein-protein interactions include those involved in signaling pathways, cell growth and development, but more specific information may depend on particular studies or databases.

### 2. Aging and Age-Related Diseases
Research has indicated that proper N-terminal acetylation is vital for various aspects of cellular function, and dysregulation of this process has been linked to certain age-related conditions. While direct associations of the NAA15 gene to aging are still under investigation, several points arise:
- **Cellular Senescence**: Changes in protein acetylation status have been implicated in cellular senescence and aging. If NAA15 expression or function declines with age, it could contribute to the aging process.
- **Neurodegenerative Diseases**: The role of NAA15 and N-terminal acetylation in neuronal development and function suggests a potential connection to neurodegenerative diseases, which often have age-related prevalence.
- **Retinal Disorders**: Given its role in controlling retinal neovascularization, NAA15 may also be implicated in age-related eye diseases such as diabetic retinopathy or macular degeneration.

### 3. Drug Interactions
Currently, there may not be well-established specific drugs targeting NAA15 directly. However, certain general approaches or classes may influence its activity or associated pathways, including:
- **HDAC Inhibitors**: Since histone deacetylation impacts acetylation pathways indirectly, these agents could modify the expression of NAA15 or its associated pathways in treating various conditions, especially cancer.
- **Anti-angiogenic drugs**: Given NAA15's involvement in neovascularization, drugs targeting pathways in angiogenesis may functionally relate to NAA15, especially in the context of retinal issues.

### 4. Pathways and Biological Processes
NAA15 is involved in several biological processes, including:
- **N-terminal Acetylation**: As part of the NatA complex, it plays a role in the post-translational modification of proteins.
- **Cell Growth and Development**: Its activity is essential for proper cellular functions in vascularization, hematopoiesis, and neurogenesis.
- **Gene Regulation**: Through interactions with XRCC5 and XRCC6, NAA15 is implicated in the regulation of transcription, influencing the osteocalcin promoter among others.
- **DNA Repair and Maintenance**: Interaction with components involved in DNA repair links NAA15 to pathways necessary for maintaining genomic stability.

The NAA15 gene thus plays a multi-faceted role in cellular physiology and pathology, with connections to broader biological processes that could impact health in the context of aging and disease. Further research continues to elucidate its functions and potential therapeutic targets.