### PPP1CC Gene Summary

**Gene Symbol:** PPP1CC  
**Description:** The PPP1CC gene encodes the gamma isoform of protein phosphatase 1 (PP1 gamma), a vital serine/threonine phosphatase involved in numerous cellular processes, including cell division, glycogen metabolism, and synaptic plasticity.

### 1. Associated Genes
In addition to the mentioned activities, there are several other genes and proteins associated with PPP1CC that are crucial for various biological functions:

- **RPS6KB1:** Regulates protein synthesis via mTOR signaling.
- **FOXP3:** Involved in regulatory T-cell function, crucial for immune tolerance.
- **CSNK1D and CSNK1E:** Kinases that phosphorylate PER proteins and are significant in circadian rhythms.
- **AKT1:** Involvement in multiple signaling pathways including cell growth and survival, which might be regulated via dephosphorylation by PPP1CC.

### 2. Aging and Age-Related Diseases
PPP1CC has been implicated in several mechanisms relevant to aging and age-related diseases:

- **Cellular Senescence:** Dysregulation of phosphorylation processes may lead to cellular aging due to impaired cell cycle regulation.
- **Age-related Cognitive Decline:** PPP1CC's role in synaptic plasticity suggests it may influence cognitive aging, particularly through its actions on proteins linked to memory and learning.
- **Autoimmune Disorders:** Alterations in the function of regulatory T-cells due to FOXP3 modification by PPP1CC dephosphorylation may contribute to age-related autoimmune disease susceptibility, such as rheumatoid arthritis.

### 3. Drug Interactions
Several drug classes and compounds may interact with PPP1CC, either through its enzymatic activity or by modifying its regulatory pathways:

- **Antineoplastic Agents:** Some cancer therapies target pathways involving PP1 to influence tumor cell division and survival, given the role of PP1 in regulating key oncogenic pathways.
- **Immunosuppressants:** Drugs that impact T-cell function and phosphatase activity might be relevant, especially targeting the dephosphorylation of FOXP3.
- **Protein Kinase Inhibitors:** Agents that modulate kinases may indirectly affect PPP1CC's activity by altering phosphorylation dynamics of its substrates.

### 4. Pathways and Biological Processes
PPP1CC is involved in a variety of pathways and processes, including:

- **Cell Cycle Regulation:** Facilitating progression during cell division by dephosphorylating key substrates involved in the transition between mitosis and interphase.
- **Glycogen Metabolism:** PP1 plays a critical role in the regulation of glycogen synthesis and breakdown.
- **Neuronal Signaling:** Modulating synaptic efficacy and plasticity over long-term, impacting learning and memory through its actions on calcium/calmodulin-dependent pathways.
- **Circadian Rhythm:** In conjunction with CSNK1 kinases, PPP1CC participates in the regulation of circadian clocks by influencing the phosphorylation state of key circadian proteins such as PER1 and PER2.

### Conclusion
The PPP1CC gene is a crucial element in a plethora of cellular processes. Its role as a serine/threonine phosphatase renders it significant not only for basic cellular functions but also for its potential implications in aging, age-related diseases, and therapeutic interactions with various drug classes. Understanding the full spectrum of its actions and interactions is vital for leveraging its functions in biomedical research and therapeutic applications.