**INTS6L-AS1 Gene Overview:**

The INTS6L-AS1 gene, also known as Intronic Non-Coding RNA for INTS6, is a long non-coding RNA (lncRNA) that is primarily known for its regulatory roles in gene expression and involvement in certain biological processes. The gene is located on chromosome 11 and may play a role in modulating the expression of genes involved in various cellular functions.

### 1. Associated Genes:
While specific associations with other genes may not be explicitly mentioned in NCBI or UniProt databases, lncRNAs like INTS6L-AS1 often interact with multiple gene networks and can influence the expression of nearby or related protein-coding genes. Some genes in proximity, or those that may share pathways with INTS6L-AS1, could include:

- **INTS6**: Although INTS6L-AS1 is a long non-coding RNA, it can have regulatory interactions with its neighboring gene INTS6, which is involved in the integrator complex that processes small nuclear RNAs (snRNAs).
- **MIR205**: MicroRNA genes often interact with lncRNAs to regulate various cellular processes.

### 2. Aging and Age-Related Diseases:
While direct studies specifically linking INTS6L-AS1 to aging or age-related diseases are limited in current literature, lncRNAs are increasingly being studied for their roles in cellular senescence and the aging process. Review of literature may reveal:

- **Cancer**: LncRNAs, including INTS6L-AS1, can be involved in tumorigenesis and metastasis, potentially linking them to age-related cancers.
- **Neurodegenerative Diseases**: Some lncRNAs play roles in neuronal survival and differentiation, which may affect age-related neurodegenerative disorders such as Alzheimer's disease.

### 3. Drug Interactions:
As of now, specific drugs or drug classes interacting directly with INTS6L-AS1 are not widely documented in the literature. However, since lncRNAs can influence drug metabolism, resistance, and efficacy:

- **Cancer Therapeutics**: Since some lncRNAs are implicated in cancer pathways, their expression might alter the response of tumors to chemotherapy agents.
- **Targeted Therapies**: Research is ongoing regarding the modulation of lncRNAs to improve the pharmacodynamics of targeted therapies.

### 4. Pathways and Biological Processes:
INTS6L-AS1 is involved in several biological pathways and processes:

- **Gene Regulation**: It may act by interaction with chromatin and transcription factors, influencing the transcription of target genes.
- **Cell Cycle Regulation**: Associations may exist where INTS6L-AS1 plays a role in cell cycle progression or senescence.
- **Response to Stress**: Long non-coding RNAs have been implicated in cellular responses to various stressors, which may relate to aging.

### Conclusion:
The INTS6L-AS1 gene represents an emerging field of study in the realm of long non-coding RNAs, particularly regarding their regulatory functions and potential associations with aging and disease. Further research could elucidate more precise functions, interactions, and therapeutic implications related to this gene.