Certainly! Here is a detailed overview of the NKX2-1-AS1 gene along with additional information.

### Gene Overview: NKX2-1-AS1

- **Gene Symbol**: NKX2-1-AS1
- **Location**: Located on chromosome 14, this gene is a long non-coding RNA (lncRNA) associated with the NKX2-1 gene, which encodes a transcription factor involved in the development of the thyroid, lung, and forebrain.

### 1. Associated Genes
While the NCBI and UniProt summaries may not list specific genes, the NKX2-1-AS1 gene has been implicated in regulatory networks involving several genes, particularly those related to lung function and development. Notable associated genes include:
- **NKX2-1**: The gene it is an antisense transcript to, which plays critical roles in lung and thyroid development.
- **SFTPA1, SFTPB, SFTPC**: Genes related to surfactant production in alveolar cells.
- **CAV1**: Associated with various pathway interactions that may involve NKX2-1-AS1.

### 2. Aging and Age-related Diseases
There is emerging evidence linking NKX2-1-AS1 to various age-related diseases, particularly those affecting lung function and neurodegenerative diseases. Research suggests that:
- **Pulmonary Diseases**: Impaired function of NKX2-1 due to regulatory alterations from NKX2-1-AS1 may contribute to age-related pulmonary disorders such as Chronic Obstructive Pulmonary Disease (COPD) and idiopathic pulmonary fibrosis.
- **Alzheimer's Disease**: NKX2-1 may be involved in cognitive decline mechanisms, and its regulatory lncRNA might also have implications in neurodegenerative changes observed in aging.

### 3. Drug Interactions
While specific drug interactions are currently less well-documented, there are ongoing studies investigating the role of lncRNAs in the response to various drug treatments. There is no current definitive list of specific drugs or drug classes known to interact with NKX2-1-AS1; however, it can be important in the following contexts:
- **Targeting Lung Disorders**: Potential for drugs aimed at regulating lung function.
- **Neurological Therapeutics**: Drugs enhancing cognitive function may indirectly interact with pathways involving NKX2-1-AS1.

### 4. Pathways and Biological Processes
NKX2-1-AS1 is involved in several pathways and biological processes, including:
- **Lung Development**: It plays a crucial role in the regulation of genes involved in pulmonary development.
- **Thyroid Hormone Signaling**: There is a link between NKX2-1 and thyroid hormone regulation processes, impacting metabolic processes.
- **Regulation of Gene Expression**: As a lncRNA, NKX2-1-AS1 can modulate gene expression; it serves as a regulatory element affecting transcriptional activity of associated genes.
- **Cell Cycle Regulation**: There is some evidence for involvement in pathways related to cell proliferation and differentiation.

### Conclusion
Overall, NKX2-1-AS1 is a non-coding RNA with significant implications in developmental biology and disease mechanisms. Its associations with aging-related pulmonary disorders and potential roles in neurodegeneration are areas of active research. Further studies could elucidate the molecular mechanisms of action and possible therapeutic avenues targeting NKX2-1-AS1 and its regulatory networks.