### PCNT Gene Overview

**Gene Symbol:** PCNT  
**Chromosomal Location:** Human chromosome 21q22.3  
**Gene Functions:** The PCNT gene encodes the protein pericentrin, which is a crucial component of the centrosome, particularly the pericentriolar material (PCM). Its primary functions include:

- Binding to calmodulin.
- Involvement in microtubule organization and nucleation through its interaction with γ-tubulin.
- Regulation of centrosome stability and preventing premature centrosome splitting during interphase.

### 1. Associated Genes
While the summary mentions interactions with gamma-tubulin and DISC1, other genes and molecular partners known to associate with PCNT include:

- **NEK2**: A kinase that PCNT regulates to prevent centrosome splitting.
- **TUBG1**: Another protein involved in microtubule nucleation.
- **CEP250**: A protein that interacts with PCM proteins and is involved in the structural integrity of centrosomes.
- **KIF2A**: A kinesin involved in microtubule dynamics, which may also interact with PCNT in some capacity.
  
### 2. Aging and Age-Related Diseases
While not directly studied, the proper functioning of PCNT and its role in centrosome integrity are critical throughout cellular division. Dysregulation or mutations in PCNT are associated with syndromes characterized by various developmental defects, which could also correlate with age-related processes:

- **Seckel Syndrome-4** and **Microcephalic Osteodysplastic Primordial Dwarfism Type II** have implications for aging because they involve neurodevelopmental delays and abnormal cell cycle regulation.
- Centrosome dysfunction has been broadly implicated in various age-related diseases, including **cancer**, due to its role in cell division and genomic stability.

### 3. Drug Interactions
While no specific drugs directly targeting the PCNT gene have been validated, classes of compounds that may influence centrosomal activity or microtubule dynamics could affect PCNT functions indirectly:

- **Microtubule-targeting agents (e.g., Taxanes and Vinca alkaloids)**: These drugs typically influence overall microtubule stability and dynamics, thereby potentially interacting with centrosomal and microtubular functions where PCNT is an integral component.
- Investigation of **Calmodulin antagonists** may also reflect changes in PCNT binding and localization, given its known calmodulin-binding characterization.

### 4. Pathways and Biological Processes
PCNT is involved in several key cellular processes and signaling pathways, including:

- **Centrosome Cycle Regulation**: Essential for normal cell cycle progression, particularly during mitosis and meiosis.
- **Microtubule Organization**: Facilitating the organization of microtubules into functional arrays.
- **Cellular Development**: Integral in the development and stability of neuroepithelial cells, impacting overall organismal development.
- **Signal Transduction**: Interacting with various cellular signals influencing the centrosomal cycle and associated processes.

### Conclusion
The PCNT gene plays a crucial role in centrosome functionality, cell cycle regulation, and microtubule organization. Mutations in this gene can lead to significant developmental disorders. While its role in aging and potential drug interactions necessitate further exploration, it remains a pivotal element in cellular biology and related pathologies.