### SMARCC1 Gene Overview

**Gene Symbol**: SMARCC1  
**Chromosomal Location**: Human chromosome 9 (9p21.3)  

The SMARCC1 gene encodes a protein that is a member of the SWI/SNF chromatin remodeling complexes, which play essential roles in regulating gene transcription by altering the chromatin structure around specific genes. The protein is essential for neural development and switches from a progenitor to a postmitotic chromatin remodeling mechanism during nerve cell differentiation.

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### 1. Associated Genes

- **ACTL6A/BAF53A**: A subunit involved in the npBAF complex.
- **ACTL6B/BAF53B**: A homolog of ACTL6A, part of the nBAF complex.
- **PHF10/BAF45A**: Component of the npBAF complex, exchanged during differentiation.
- **DPF1/BAF45B**: Subunit in the nBAF complex.
- **DPF3/BAF45C**: Another alternative subunit in the nBAF complex.

Additionally, other proteins interacting with SMARCC1 might include:
- **BRG1 (SMARCA4)**: The ATPase component of the SWI/SNF complex.
- **BRM (SMARCA2)**: Another ATPase component of the homologous complexes.
- **CREST**: Involved in dendrite growth regulation during neural differentiation.

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### 2. Aging and Age-Related Diseases

While direct associations of SMARCC1 with aging or age-related diseases are limited, chromatin remodeling plays a critical role in gene expression regulation associated with aging. Dysregulation of chromatin remodeling complexes, including SWI/SNF, has been implicated in various age-related diseases. Potentially relevant connections include:

- **Neurodegenerative diseases**: Altered chromatin remodeling may affect the expression of genes related to neuronal health and function, potentially contributing to conditions such as Alzheimer's disease or other dementias.
- **Cancer**: Mutations or alterations in chromatin remodeling components, including those in SWI/SNF complexes like SMARCC1, are commonly seen in various tumors. Age is a critical factor in cancer development, where chromatin dynamics change with potential epigenetic changes.

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### 3. Drug Interactions

While there are no specific drugs directly targeting SMARCC1 documented, drugs that impact chromatin remodeling or histone deacetylase inhibitors (HDAC inhibitors) may indirectly affect SMARCC1 functions. 

**Drug Classes**:
- **Histone Deacetylase Inhibitors**: Such as Vorinostat and Romidepsin can influence chromatin structure and gene expression, thereby possibly affecting the action of SWI/SNF complexes.
- **ATPase inhibitors**: Though none are directly mentioned for SMARCC1, broader SWI/SNF activity may relate to compounds that modulate ATPase activities in chromatin remodeling contexts.

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### 4. Pathways and Biological Processes

The SMARCC1 gene is involved in several important biological pathways and processes:

- **Chromatin remodeling**: Adjusting DNA-histone interactions in a manner dependent on ATP usage, crucial for gene expression regulation.
- **Neurogenesis**: Involvement in the transition of neural progenitors to fully differentiated neurons.
- **Regulatory transcription**: Plays roles in both transcriptional activation and repression, affecting cellular responses and differentiation.
- **Developmental signaling pathways**: Interacts with pathways regulating neuronal differentiation and plasticity, which may include Wnt, Notch, and others.

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In conclusion, the SMARCC1 gene plays a multifaceted role in transcriptional regulation through chromatin remodeling, particularly crucial during neural development. Its interactions with other chromatin remodelers point to a complex network influencing cell fate and gene expression across developmental stages and potentially implicating it in age-related processes and diseases.