**KRT8P37 Gene Overview:**

- **Gene Symbol:** KRT8P37
- **Description:** KRT8P37 is a pseudogene located on chromosome 12, related to the keratin family of genes. Keratins are a group of fibrous structural proteins that are key components of the cytoskeleton in epithelial cells. Pseudogenes are segments of DNA that resemble functional genes but have lost their protein-coding ability, often due to mutations.

### 1. Associated Genes:
While the summaries may not mention specific associated genes, it's common for keratin genes to be linked together in pathways related to cytoskeletal structure and function. Keratins that may be closely related to KRT8P37 include:
- **KRT8**: Functional keratin that plays a role in forming intermediate filaments in the cytoskeleton of epithelial tissues.
- **KRT18**: Often co-expressed with KRT8 in simple epithelial cells.
- **KRT19**: Another keratin that may be implicated in similar biological processes.

There are numerous other keratin genes that may also be relevant, considering the extensive family of keratins involved in epidermal and mucosal integrity (e.g., KRT7, KRT14).

### 2. Aging and Age-Related Diseases:
Currently, there is limited specific information on KRT8P37’s direct involvement in aging or age-related diseases, as it is a pseudogene and likely not actively expressed. However, the keratin family, including functional keratins like KRT8 and KRT18, has been linked to aging and age-related skin conditions (like wrinkles and reduced elasticity) and diseases such as cancer. Altered expression of keratin genes can indicate cellular stress responses that are relevant in aging.

### 3. Drug Interactions:
Since KRT8P37 is a pseudogene, there are no known direct drug interactions with this specific gene. However, functional keratin genes (like KRT8 and KRT18) have been studied in the context of drug response, especially in epithelial cancers, where expression levels can affect tumor behavior and response to chemotherapy.

### 4. Pathways and Biological Processes:
- **Keratinization:** Pseudogenes don't participate directly in biological processes but are often involved in regulatory mechanisms surrounding their functional counterparts.
- **Cellular Structure Maintenance:** Keratins contribute to the structural integrity of epithelial cells.
- **Response to Stress:** Functional keratins are involved in cellular responses to various stresses, influencing cell survival and function.

In summary, while KRT8P37 is a pseudogene and may not be directly involved in biological processes, it is associated with the broader context of keratin gene expression and its implications in cellular biology. For additional investigations, focusing on functional keratin genes like KRT8 may yield more insights into aging, disease, and drug interactions.