### Overview of KRT73-AS1 Gene

**Gene Symbol**: KRT73-AS1  
**Location**: Chromosome 17  
**Type**: Long non-coding RNA (lncRNA)

KRT73-AS1 is an antisense non-coding RNA gene that is located adjacent to the KRT73 gene, which encodes keratin 73, a member of the keratin protein family involved in the structural integrity of epithelial cells. The role of KRT73-AS1 is less well-defined, but like many lncRNAs, it may play critical regulatory roles in gene expression, chromatin remodeling, and the modulation of cellular processes.

### 1. Associated Genes

While specific associations may not be well-documented, KRT73-AS1 is closely linked to the keratin gene family, particularly:

- **KRT73**: Keratin 73 - involved in maintaining the structural integrity of keratinocytes.
- **KRT7** and **KRT17**: Other keratin genes, which may have collaborative functions in epithelial health and disease.

### 2. Aging and Age-related Diseases

Research into the specific roles of KRT73-AS1 in aging or age-related diseases is limited. However, in a broader perspective of lncRNAs:

- **Senescence**: Some lncRNAs are known to be implicated in cellular senescence, a process often associated with aging.
- **Cancer**: Alterations in lncRNA expression, including those surrounding keratin genes, have been associated with cancer progression, which can correlate with age-related disease incidence.

### 3. Drug Interactions

Currently, there is no established list of specific drugs or drug classes that directly interact with KRT73-AS1. However, given that lncRNAs can influence drug responses and modulate pathways targetable by therapeutics, this gene's products may indirectly affect therapeutic outcomes through their regulatory roles.

### 4. Pathways and Biological Processes Involved

KRT73-AS1 may be involved in various biological processes typically associated with lncRNAs and keratins, including:

- **Regulation of Gene Expression**: As a long non-coding RNA, KRT73-AS1 may regulate the transcription of nearby genes, impacting keratinocyte biology.
- **Epithelial Cell Differentiation**: It likely plays a role in the differentiation and function of epithelial cells through the regulation of keratin gene expression.
- **Cellular Responses to Stress**: Keratins are involved in cellular responses to mechanical stress; thus, KRT73-AS1 might also participate in signaling pathways related to stress responses.

### Conclusion

Though KRT73-AS1 is primarily recognized as a long non-coding RNA associated with the keratin family, existing research does not yet provide comprehensive insights into its specific molecular roles, particularly concerning aging, drug interactions, and pathways. Further studies are needed to delineate its functions and clinical relevance comprehensively.