### Gene Summary: ENO1-AS1

**Gene Symbol:** ENO1-AS1  
**Species:** The ENO1-AS1 gene is present in various species including humans (Homo sapiens) and plays a role in the cellular processes associated with energy metabolism and stress response. 

#### 1. Associated Genes
ENO1-AS1 (also known as ENO1 antisense RNA 1) is primarily associated with the following genes:
- **ENO1 (Enolase 1)**: The main target and antisense gene of ENO1-AS1, involved in glycolysis.
- **HIF1A (Hypoxia-inducible factor 1-alpha)**: Involved in responses to low oxygen levels.
- **VEGFA (Vascular Endothelial Growth Factor A)**: Connected to angiogenesis.
- Other genes may include those involved in metabolic pathways or under hypoxic conditions.

#### 2. Aging and Age-related Diseases
Research has implicated ENO1-AS1 in several aspects related to aging:
- **Cancer**: This gene has been linked to several types of malignancies, including lung and colorectal cancer. It may play a role in tumor metabolism and the cancer progression environment.
- **Metabolic Disorders**: Abnormalities in ENO1, and by extension ENO1-AS1, can influence metabolic pathways that are disrupted in age-related diseases such as diabetes and obesity.
- **Cellular Senescence**: There is emerging data suggesting involvement of ENO1-AS1 in cellular senescence processes, which are tied to aging and various degenerative diseases.

#### 3. Drug Interactions
Currently, specific drugs or drug classes that directly target or interact with ENO1-AS1 are not well-established. However, understanding its function may provide insights into:
- **Anticancer Therapies**: Compounds affecting glucose metabolism could indirectly interact due to the regulatory role of ENO1-AS1 on ENO1, which is integral in cancer cell metabolism.
- **Metabolic Modulators**: Drugs that influence metabolic pathways may interact with the cellular functions mediated by ENO1 and ENO1-AS1.

#### 4. Pathways and Biological Processes
ENO1-AS1 is involved in several key biological pathways, including but not limited to:
- **Glycolysis and Gluconeogenesis**: ENO1-AS1 plays a role in regulating ENO1, a critical enzyme in the glycolytic pathway.
- **Hypoxia Pathway**: Associated with the regulation of genes under low oxygen conditions.
- **Cellular Metabolic Processes**: Plays a role in the regulation of various metabolic pathways, impacting overall cellular energy homeostasis.
- **Apoptosis and Cell Proliferation**: Impacts cancer cell behavior through regulation of metabolic adaptation during aggressive growth.

### Summary
The ENO1-AS1 gene has notable associations with various other genes, particularly involved in metabolism and hypoxic responses. Its involvement in aging and age-related diseases, though still under investigation, indicates pathways relevant to cancer and metabolic processes. While direct drug interactions remain unspecific, the gene plays a potential role in the context of therapies targeting cancer metabolism and metabolic disorders. Further research is needed to fully understand its implications in these areas.