### PRMT2 Gene Overview

**Gene Symbol:** PRMT2  
**Location:** Cytosol and nucleoplasm  
**Functions:**  
- **Nuclear receptor binding activity**
- **Peroxisome proliferator-activated receptor binding activity**
- **Protein homodimerization activity**

**Involved processes:**  
- Histone methylation
- Regulation of androgen receptor signaling pathway
- Regulation of transcription, DNA-templated

**Protein Summary:**  
PRMT2 encodes an arginine methyltransferase that specifically methylates the guanidino nitrogens of arginyl residues in various proteins, including STAT3, FBL, and histone H4. It serves as a coactivator for androgen receptors and estrogen receptors, enhancing their transcriptional activities. In addition, PRMT2 might inhibit NF-kappa-B transcription and promote apoptosis, along with repressing E2F1 transcriptional activity in an RB1-dependent manner, indicating a potential role in growth regulation.

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### 1. Associated Genes
While the summaries provided mention significant interaction with androgen and estrogen receptors (AR, ER) along with other proteins like STAT3, there may be associations with other genes related to pathways in cancer and cellular signaling. Some notable genes associated with PRMT2 include:
- **NCOA2** (nuclear receptor coactivator)
- **RB1** (retinoblastoma gene)
- Various genes involved in the NF-kappa-B signaling pathway.

### 2. Aging and Age-Related Diseases
Research has suggested a potential role for PRMT2 in aging and age-related diseases, particularly due to its involvement in the regulation of transcription and possible interactions with pathways linked to cancer, cellular growth, and apoptosis. Dysregulation of PRMT2 has been linked to:
- Cellular senescence
- Tumor progression or development due to its role in transcriptional regulation
- Potential implications in neurodegenerative diseases where arginine methylation is altered

### 3. Drug Interactions
While specific small molecules or drugs targeting PRMT2 directly might not be extensively documented, its functions indicate potential interactions with:
- **Anti-cancer agents:** Cisplatin and other chemotherapeutics may interact with PRMT2 due to its role in apoptosis and cell growth control pathways.
- **Hormonal therapies:** Drugs acting on androgen receptors or estrogen receptors could indirectly affect PRMT2’s function as a coactivator.
- **Histone methylation modifiers:** Since PRMT2 is involved in histone methylation, certain epigenetic-modifying drugs that target histone methyltransferases might also interact with the pathways influenced by PRMT2.

### 4. Pathways and Biological Processes
PRMT2 is involved in several key biological processes and pathways:
- **Gene Transcription Regulation:** Involved in DNA-templated transcription regulation, specifically through its roles in modulating the activity of nuclear receptors like AR and ER.
- **Oncology Pathways:** May have implications in cancer biology via modulation of transcription factors like NF-kappa-B and E2F1, affecting cell proliferation and apoptosis.
- **Stress and Apoptotic Response:** PRMT2 is implicated in apoptosis regulation, enhancing or inhibiting various stress responses within the cell.
- **Developmental Pathways:** The gene may influence developmental processes mediated by nuclear receptors through early developmental signaling pathways.

In summary, PRMT2 is a multifaceted gene with significant roles in transcriptional regulation, receptor signaling, and possibly impacts on aging and various diseases, especially cancer. Its interactions with other genes, influence by drugs, and involvement in critical biological processes underscore its potential importance in both fundamental biology and therapeutic targeting.