### GMPSP1 Gene Overview

**Gene Symbol:** GMPSP1

**Description:** GMPSP1 (Guanylate monophosphate synthetase pseudogene 1) is a pseudogene located on chromosome 1. As a pseudogene, it is generally considered to be a non-functional counterpart to the functional gene GMPS, which is involved in nucleotide synthesis pathways.

### 1. Associated Genes
GMPSP1 is closely related to its parental gene GMPS, which encodes a protein responsible for converting GMP to GDP as part of purine metabolism. Other genes that might be relevant in this context include:

- **GMPS:** The functional guanylate monophosphate synthetase.
- **NME1 and NME2:** Genes involved in related nucleotide metabolic processes.
- **GMPPB:** Involved in the metabolism of nucleotides and linked with similar pathways.

### 2. Aging and Age-related Diseases
While specific studies directly linking GMPSP1 to aging or age-related diseases are limited, the functional GMPS gene has been implicated in metabolic processes that could affect cellular longevity and proliferation. Dysregulation of nucleotide synthesis pathways, of which GMPS is a key player, might contribute to cellular senescence and age-related pathologies. However, specific associations with GMPSP1 remain under-investigated.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes directly associated with GMPSP1 due to its status as a pseudogene. However, drugs targeting GMPS may indirectly affect cellular processes wherein GMPSP1 is situated. Classes of drugs or compounds that could theoretically impact nucleoside metabolism include:

- **Antivirals (e.g., Acyclovir, Ganciclovir):** These often target nucleotide synthesis.
- **Chemotherapeutics:** Drugs used in cancer treatment may also interact with nucleotide metabolism.

### 4. Pathways and Biological Processes
GMPSP1 itself does not actively participate in biological pathways due to being a pseudogene. However, the pathways related to its functional counterpart, GMPS, include:

- **Purine Nucleotide Metabolism:** Involves synthesis and degradation of purine nucleotides.
- **Nucleotide Salvage Pathway:** Helps recycle nucleotides from catabolism of nucleic acids.
- **Cellular Metabolism:** Impacts cell proliferation, survival, and DNA synthesis.

### Summary
The GMPSP1 gene, while non-functional, exists in the context of purine metabolism through its association with GMPS and potentially other related genes. Its direct implications on aging, disease, and drug interactions are minimal due to its pseudogene status, yet the mechanisms of metabolism it is associated with are critical in various biological contexts including cancer and cellular aging. More targeted studies are needed to explore the implications of GMPSP1 in greater detail.