### PHACTR3 Gene Overview

**Gene Symbol:** PHACTR3  
**Location:** Human Chromosome 10 (10q25.3)  
**Protein Product:** Phosphatase and Actin Regulator 3

PHACTR3 belongs to the phosphatase and actin regulator protein family, which implicates its role in the regulation of protein phosphatases and actin dynamics. The protein product plays critical roles in cellular processes related to cytoskeleton organization, cell proliferation, and signal transduction due to its interactions with actin and phosphatases.

### 1. Associated Genes

While specific gene associations were not detailed in the summaries provided, other genes and proteins that may have functional links to PHACTR3 include:

- **PPP1CA (Protein Phosphatase 1 Catalytic Subunit Alpha):** As PHACTR3 binds to the catalytic subunit of protein phosphatase-1, this connection is significant for understanding its role in dephosphorylation pathways.
- **ACTB (Beta-Actin):** The interaction with actin suggests a functional relationship with other cytoskeletal proteins, including actin itself.
- **RHOA (Ras Homolog Family Member A):** As a GTPase that regulates the cytoskeleton, it may interact indirectly through pathways that involve actin remodeling.
- **PAX6 (Paired Box 6):** Alteration in PHACTR3 expression has been studied in the context of neurodevelopment, where PAX6 is also implicated.

### 2. Aging and Age-Related Diseases

Current research surrounding PHACTR3 has indicated its potential roles in age-related processes, although specific gene ontology for aging may not be well characterized. Some points of interest include:

- **Cellular Senescence:** PHACTR3's association with nuclear scaffolds suggests a role in maintaining genome integrity, which is essential for cellular stability through aging.
- **Cancer:** Alterations in PHACTR3 expression can be linked to various cancers. As aging is a prominent risk factor for many forms of cancer, this gene may play a role in age-related tumorigenesis through its regulatory functions in cell proliferation and actin dynamics.

### 3. Drug Interactions

As of the most current data available, no specific drugs or drug classes have been broadly documented to target PHACTR3 directly. However, given its involvement in pathways involving protein phosphatase-1, it could hypothetically be implicated indirectly in the following broader classes:

- **Phosphatase Inhibitors:** Some of the intervention strategies targeting protein phosphatase-1 may affect PHACTR3 indirectly, with potential modulatory effects on its activity.
- **Chemotherapeutic agents:** Drugs targeting actin dynamics may alter the cellular functions of PHACTR3, but specific interactions require further research.

### 4. Pathways and Biological Processes

PHACTR3 is involved in various pathways and biological processes, which include but are not limited to:

- **Cytoskeleton Organization:** Influencing actin polymerization and function as it interacts with β-actin.
- **Cell Proliferation:** Acting as a regulator of phosphatase activity, it is likely involved in controlling cell cycle progression and survival.
- **Regulation of Protein Dephosphorylation:** By modulating the activity of protein phosphatase-1, it plays an integral role in phospho-regulatory networks impacting diverse cellular functions.
- **Cell Communication and Signal Transduction:** Given PHACTR3's involvement in scaffolding complexes, it is also likely relevant in cellular signaling processes and transcriptional regulation within the nucleus.

### Conclusion

PHACTR3 serves an essential function in cellular processes related to actin dynamics and phosphatase regulation. Ongoing research may uncover deeper insights into its role in aging and disease, as well as potential therapeutic avenues associated with its regulatory functions.