### SRGAP2C Gene Overview

**Gene Symbol:** SRGAP2C  
**Location:** Chromosome 1  

#### Summary
The SRGAP2C gene encodes a member of the SLIT-ROBO Rho GTPase-activating protein family. It arose through a segmental duplication of the SRGAP2B locus, which is noted for its significance in human-specific brain evolution. While the gene product lacks the GTPase-activating protein domain typical of other family members, it serves as an antagonist to SRGAP2 and SRGAP2A, influencing cortical neuron development, synaptic maturation, and local as well as long-range cortical connectivity.

### Associated Genes
1. **SRGAP2**: The ancestral paralog, plays a role in the maturation and density regulation of synapses.
2. **SRGAP2A**: Similar to SRGAP2, with roles in neocortical development. 
3. **SLIT genes**: Members of the same family that are involved in axon guidance and synaptic function.
4. **RHOA and RAC1**: Rho GTPases that are influenced by SRGAP2 family proteins in cytoskeletal dynamics and neuronal development.

### Aging and Age-related Diseases
The role of SRGAP2C in cortical connectivity suggests it may contribute to cognitive processes that decline with aging, such as synaptic plasticity and memory. Research is ongoing to understand its potential association with neurodegenerative conditions such as Alzheimer's disease and autism spectrum disorders, given its functions in synaptic regulation. Alterations in synaptic density and maturation processes can impact neurodevelopmental and neurodegenerative pathways associated with aging.

### Known Drug Interactions
Currently, there are no specific drugs or drug classes directly noted to interact with SRGAP2C. However, due to its role in synaptic function, pathways modulating glutamate receptor signaling, neuroprotective agents, and compounds influencing synaptic plasticity may indirectly affect its activity or the pathways involved.

### Biological Processes and Pathways
1. **Synaptic Development & Plasticity**: Regulates the balance between excitatory and inhibitory synaptic architecture and function.
2. **Cortical Neuron Development**: Impacts the formation and maturation of cortical networks critical for complex brain functions.
3. **Neurogenesis**: Potentially involved in the production and maturation of neurons during development and possibly in adult neurogenesis.
4. **Proteasomal Degradation**: Induces proteasome-dependent degradation of SRGAP2/SRGAP2A, modulating their functional levels.

### Conclusion
The SRGAP2C gene plays a significant role in human-specific cortical development and connectivity, acting as a fine-tuner of synaptic dynamics and potential modifiers of cognitive functions. Further research into its interactions with other genes, its implications in aging, and potential therapeutic targets remains critical to fully elucidate its role in both normal and pathological conditions of the brain.