### CALM3 Gene Overview

**Gene Symbol:** CALM3  
**Location:** Chromosome 19  
**Function:** The CALM3 gene encodes calmodulin, a calcium-binding protein that plays a crucial role in various calcium-dependent cellular processes. 

### 1. Associated Genes

Beyond the involvement of CCP110 and centrin in the centrosome cycle and cytokinesis, CALM3 is associated with several other genes and proteins, including:

- **MYLK (Myosin Light Chain Kinase):** Myosin light chain phosphorylation is mediated via calmodulin, which is activated in a calcium-dependent manner.
- **CAMK2 (Calmodulin-Dependent Protein Kinase II):** Another key target activated by CALM3 in the presence of calcium, involved in learning and memory in neurons.
- **PP2B (Calcineurin):** A calcium/calmodulin-dependent serine/threonine protein phosphatase.
- **NOS (Nitric Oxide Synthase):** Activation of nitrous oxide production can be mediated by the calmodulin/calcium complex.
- **AQP (Aquaporins):** A family of water channel proteins regulated via calmodulin.

### 2. Aging and Age-Related Diseases

While the direct involvement of CALM3 in aging and age-related diseases is not extensively characterized, its role in cellular processes such as signal transduction, cell cycle regulation, and cytokinesis may contribute to these areas. Some general points related include:

- **Cardiovascular Aging:** Altered calcium signaling is associated with aging in cardiac tissues, potentially implicating calmodulin pathways in age-related cardiac dysfunction.
- **Neurodegeneration:** Given its role in signaling pathways important for synaptic plasticity and memory through CAMK2, dysregulation of CALM3 may participate in neurodegenerative diseases such as Alzheimer’s disease.
- **Cancer:** Changes in calmodulin expression and function can disrupt normal cell cycle regulation, contributing to tumorigenesis as organisms age.

### 3. Known Drug Interactions

CALM3 interacts with several classes of drugs, including:

- **Calcium Channel Blockers:** These may indirectly affect calmodulin activity by altering calcium concentrations. Examples include Verapamil and Diltiazem.
- **Immunosuppressants:** Such as Cyclosporine A, which inhibits calcineurin activation by calmodulin, affecting T-cell activation.
- **Potentially Other Molecules:** Some small molecule inhibitors and activators that modulate calcium signaling pathways may also interact indirectly with CALM3 activity.

### 4. Pathways and Biological Processes

The CALM3 gene is involved in multiple biological pathways and processes, including but not limited to:

- **Calcium Signal Transduction Pathway:** Essential for various cellular responses to calcium concentrations.
- **Cell Cycle Regulation:** Participates in the control of the cell cycle and progression through mitosis and cytokinesis.
- **ECM-receptor Interaction:** Modulating responses to extracellular matrix components.
- **Neurotransmitter Release:** Involved in the signaling pathways of neuronal cells, impacting synaptic functions.
- **Muscle Contraction:** Through its role in myosin light chain kinase activation.

In summary, the CALM3 gene is a vital component in calcium signaling pathways, interacting with multiple proteins and being implicated in various physiological processes essential for cellular function. Its associations with aging, age-related diseases, and drug interactions further demonstrate its importance in health and disease.