**SNORD114-28 Gene Overview**

The SNORD114-28 gene (small nucleolar RNA, C/D box 114-28) is a member of the C/D box small nucleolar RNA (snoRNA) family. These RNAs are primarily involved in the modification of other RNAs, such as ribosomal RNA (rRNA), through methylation and pseudouridylation processes. The SNORD114-28 gene is located on chromosome 14 and is part of the SNORD114 cluster, which consists of several closely related snoRNAs.

### 1. Associated Genes
The SNORD114-28 gene is associated with several other genes, particularly those involved in RNA modification and processing. While specific associations can depend on individual studies and data sets, some genes that may be relevant include:
- **SNORD114** cluster genes (e.g., SNORD114-1, SNORD114-2)
- **NOP56** and **NOP58**: These genes encode core components of the snoRNP complexes that are involved in the function of snoRNAs.
- **RPL5**, **RPL11**: Genes encoding ribosomal proteins, which may be influenced or targeted by the modifications facilitated by snoRNAs.

### 2. Aging and Age-related Diseases
While direct studies specifically associating SNORD114-28 with aging or age-related diseases are limited, snoRNAs and their modifications are essential for the proper function of ribosomes and consequently protein synthesis. Impairments in these processes have been linked to:
- **Cellular senescence**: Changes in RNA processing machinery can contribute to the cellular aging process.
- **Neurodegenerative diseases**: Some studies suggest that disruptions in RNA modification (which could involve snoRNAs) may contribute to age-related neurodegeneration, although specific links to SNORD114-28 await direct investigation.
- **Cancer**: Alterations in snoRNAs have been implicated in various cancers, suggesting a potential role of SNORD114-28 in tumorigenesis with age.

### 3. Drug Interactions
At present, there are no specific drugs or drug classes directly known to interact with SNORD114-28. However, several classes of drugs affecting general RNA metabolism (like those targeting RNA polymerase or involved in epigenetic regulation) can indirectly act upon snoRNA functions. Further research is needed to identify any specific pharmacological interactions.

### 4. Pathways and Biological Processes
The SNORD114-28 gene is involved in several important biological processes:
- **Ribosomal RNA modification**: As a snoRNA, it plays a role in guiding the methylation of rRNA, which is crucial for the assembly and function of ribosomes.
- **RNA processing**: Involvement in maturation of rRNA and possibly other RNA transcripts.
- **Nuclear function**: It participates in the nucleolar processes, helping to ensure proper ribosome biogenesis, which is critical for cellular protein synthesis.

SNORD114-28, like other snoRNAs, functions as part of the larger snoRNP (small nucleolar ribonucleoprotein) complexes, which are necessary for the proper processing and modification of rRNA. 

In conclusion, while SNORD114-28 itself may not have extensive direct associations with aging or drug interactions, it plays an important functional role in RNA modification processes and is associated with genes involved in ribosome function, which are relevant in the context of cellular aging and disease. Further studies are necessary to elucidate its specific roles in these processes.