### DHX58 Gene Overview

The **DHX58** gene encodes a cytoplasmic helicase that plays a critical role in the innate immune response against various viruses. It is known for its ability to bind to both double-stranded RNA (dsRNA) and single-stranded RNA (ssRNA), with a higher affinity for dsRNA, particularly 5'-triphosphorylated RNA. DHX58 acts as a regulator of antiviral signaling pathways mediated by RIG-I (retinoic acid-inducible protein I) and IFIH1/MDA5 (interferon-inducible helicase 1). 

### 1. Genes Associated with DHX58

While the summaries provided mention its interactions primarily with RIG-I and IFIH1/MDA5, the following additional genes may also be associated with DHX58 based on its regulatory functions in viral immunity:

- **MAVS (Mitochondrial Antiviral Signaling Protein)**: DHX58 regulates MAVS-dependent signaling pathways.
- **IRF3 (Interferon Regulatory Factor 3)**: DHX58's inhibitory action can affect IRF3 activation through its interactions with MAVS.
- **IKBKE (Inhibitor of Nuclear Factor Kappa B Kinase Subunit ε)**: Competitive interactions with IKBKE may also implicate this gene in DHX58's regulatory role.

### 2. Aging and Age-Related Disease Associations

Current research directly linking DHX58 to aging or age-related diseases is limited. However, the following points can offer insight into potential associations:

- **Inflammation and Immune Function**: As individuals age, immune responses often become less effective (immunosenescence). Given DHX58's role in immune regulation, it could be influenced by age-related changes in immune function.
- **Viral Infections and Disease**: Age-related increases in susceptibility to viral infections, such as influenza and SARS-CoV-2, may involve dysregulation of pathways in which DHX58 is active.
- **Chronic Inflammatory Diseases**: As chronic inflammation is a hallmark of many age-related diseases, including neurodegenerative disorders, there may be an indirect connection through the modulation of inflammatory responses.

### 3. Known Drug Interactions

As of now, specific drug interactions with DHX58 have not been extensively characterized. However, some classes of drugs that may have indirect interactions through influencing immune responses include:

- **Antivirals**: Drugs targeting viral replication processes could potentially modulate the function of proteins, including DHX58, as part of a broader immune response.
- **Immunomodulators**: Drugs that alter immune system activity may impact the functionality of DHX58, particularly in the context of treating viral infections.

Be aware that specific interactions may still require further validation via experimental data or clinical studies.

### 4. Pathways and Biological Processes

DHX58 is involved in several key pathways and biological processes, including:

- **Innate Immune Response**: DHX58 plays an integral role in pathogen recognition and triggering the innate immune response to RNA viruses.
- **Interferon Signaling Pathway**: It is critical in modulating type I interferon signaling in response to viral infections.
- **RNA Metabolism**: The gene is involved in RNA unwinding and processing, which is crucial for effective immune surveillance.
- **Negative Regulation of Defense Responses**: Besides its positive roles, DHX58 can also act negatively to fine-tune immune signaling and prevent excessive inflammation.

Overall, DHX58 stands as an important player in the antiviral immune response, with roles that may vary based on the specific viral context and host cell environment. As research continues, its potential implications in health, disease, and aging may become clearer.