### PPIAL4C Gene Overview

**Gene Symbol:** PPIAL4C  
**Location:** Human chromosome 2q37.3  
**Function:** The PPIAL4C gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which plays a crucial role in protein folding by catalyzing the isomerization of proline imidic peptide bonds. This activity is essential for proper protein conformation and functionality.

### Additional Gene Associations

Although the gene summaries from NCBI and UniProt do not provide specific associations, PPIAL4C may be connected to other genes functioning in similar pathways or biological processes. Other potential associated genes may include, but are not limited to:

- **PPIA** (Peptidylprolyl Isomerase A): Another member of the PPIase family known for its role in protein folding and function.
- **PPIB** (Peptidylprolyl Isomerase B): Involved in protein folding in the endoplasmic reticulum.
- **PPIL1**: Involved in RNA splicing, it could have functional links through shared pathways of protein regulation.

### Aging and Age-Related Diseases

Research directly linking PPIAL4C to aging or age-related diseases is limited. However, prolyl isomerases are generally recognized for their involvement in:

- **Neurodegenerative diseases**: Since misfolded proteins contribute to conditions like Alzheimer's, Parkinson's, or Huntington's disease, it is plausible that PPIAL4C could play a role in these processes.
- **Cellular stress responses**: Aging is often accompanied by oxidative stress and misfolded proteins, which may lead to increased expression or altered regulation of PPIases, including PPIAL4C.
- **Inflammatory processes**: Some PPIases are linked with inflammatory signaling pathways, which can change with age.

### Drug/Drug Classes Interactions

PPIAL4C is predicted to enable cyclosporin A binding activity. **Cyclosporin A** is a well-known immunosuppressant used in organ transplant cases, as well as in certain autoimmune conditions. Other potential interactions with drugs in this class may include:

- **Macrolide antibiotics**: Some have been noted to interact with PPIases.
- **FK506 (Tacrolimus)**: Another immunosuppressant whose actions are mediated via PPIases.

### Pathways and Biological Processes

PPIAL4C is associated with the following pathways and processes:

1. **Protein Folding**: Fundamental for maintaining cellular homeostasis and function.
2. **Peptidyl-prolyl Isomerization**: A key enzymatic activity in modifying protein conformation.
3. **Vesicle-mediated transport**: Localized in exosomes, it may have roles in cellular communication.
4. **Response to Pathogens**: Potential involvement in immune response mechanisms through modulation of protein activity.

Research into the specific pathways and roles of PPIAL4C is ongoing, and further studies could elucidate its broader functional relevance in human health and disease.