### RASSF8-AS1 Gene Overview

**Gene Symbol:** RASSF8-AS1

RASSF8-AS1 is a long non-coding RNA (lncRNA) gene associated with the RASSF8 gene. Non-coding RNAs like RASSF8-AS1 are increasingly recognized for their regulatory roles in gene expression and cellular processes.

#### 1. Associated Genes
RASSF8-AS1 is known to have a relationship with the following genes:
- **RASSF8:** The primary gene with which RASSF8-AS1 is directly associated, known to be involved in tumor suppression mechanisms.
- Other genes that may show expression correlations or interactions through various biological pathways could include:
  - **RASSF1:** Another member of the RASSF family, involved in cancer biology.
  - **RASSF6:** Potentially linked in the context of cellular signaling pathways.
  
The interactions and associations can sometimes extend based on context, cellular conditions, and specific tissue types, so experimental validation may be required for definitive associations.

#### 2. Aging and Age-Related Diseases
While specific studies focusing solely on RASSF8-AS1 in relation to aging are limited, its association with the RASSF family, some of which are implicated in tumor suppressor activity, suggests potential roles in age-related diseases, particularly cancers. Alterations in lncRNA expressions—including RASSF8-AS1—are often linked to age-related pathologies like:
- **Cancer:** Age is a considerable risk factor for many types of cancer, and the expression of non-coding RNAs, including lncRNAs, fluctuates with age. Disruptions in the regulatory functions of lncRNAs like RASSF8-AS1 may contribute to tumorigenesis.
- **Cellular Senescence:** Non-coding RNAs have roles in cellular senescence, which is a significant aspect of aging and age-related phenotypes.

#### 3. Drug Interactions
As of October 2023, there are limited specific drug interactions documented with RASSF8-AS1. However, its role as a lncRNA implies potential indirect interactions with pharmacological agents involved in:
- **Cancer therapies:** Drugs aimed at targeting pathways related to RASSF family proteins, such as those involved in apoptosis or cell cycle regulation, could influence or be influenced by the expression of RASSF8-AS1.
- General lncRNA-targeting drugs (more of a theoretical framework, as specific approved drugs targeting RASSF8-AS1 are not available at this time).

#### 4. Pathways and Biological Processes
RASSF8-AS1 has been implicated in several biological processes and pathways, principally through its relationships with other coding genes and their pathways:

- **Cell Cycle Regulation:** It may play a role in mediating cell cycle checkpoints, especially in the contexts of neoplasm.
- **Apoptosis:** Through regulatory interactions with cell signaling pathways linked to apoptosis (programmed cell death).
- **Cancer Pathways:** RASSF8-AS1, through its association with the RASSF8 gene, likely has functional importance in various cancer-related signaling pathways, affecting growth and proliferation.
- **Cytoskeletal Organization:** There could be implications in processes related to cell morphology and structure.

In conclusion, while RASSF8-AS1 is still under investigation, understanding its role in cellular functions and how it mediates relationships with other genes will be crucial for elucidating its significance in aging and cancer pathologies. Further research will clarify its involvement in pharmacological contexts and specific disease mechanisms.