### EHBP1 Gene Overview

**Gene Symbol**: EHBP1  
**Function**: Encodes an Eps15 homology domain-binding protein involved in endocytic trafficking, actin reorganization, and vesicle transport.

#### 1. Associated Genes
While the summaries provided do not explicitly mention associated genes, the EHBP1 gene has been linked to various cellular processes that involve other genes, particularly those related to endocytosis and vesicle trafficking. Some genes that may be associated with EHBP1 based on functional pathways include:
- **RAB family genes (e.g., RAB10, RAB8A)**: These are involved in vesicle trafficking and may function as partners or effectors along with EHBP1.
- **SLC2A4/GLUT4**: This gene is crucial for glucose transport and is influenced by EHBP1 in adipose tissue.
- **Eps15**: As EHBP1 is an Eps15 homology domain-containing protein, it might have functional relevance with this gene involved in clathrin-mediated endocytosis.
- **ACTB**: The actin-coding gene may also be functionally connected due to EHBP1's role in actin reorganization.

#### 2. Aging and Age-Related Diseases
There is potential significance for EHBP1 in aging and age-related diseases, particularly given its connection with endocytic trafficking and insulin-regulated processes:
- **Metabolic Disorders**: Dysregulation of glucose transport (GLUT4) is associated with insulin resistance and diabetes, which are age-related conditions.
- **Neurodegenerative Diseases**: The altered endocytic pathways may impact neuronal health and contribute to diseases such as Alzheimer’s, although specific associations have not been well characterized.
- **Cancer**: The association of a single nucleotide polymorphism (SNP) in EHBP1 with aggressive prostate cancer suggests potential links to age-related cancer risk.

#### 3. Drug or Drug Classes
Currently, there are no well-defined drugs or drug classes published that specifically interact with the EHBP1 gene or its protein product directly. However, given its role in insulin signaling and glucose metabolism, drugs aimed at insulin sensitivity (e.g., Metformin) or glucose-lowering therapies may indirectly influence pathways involving EHBP1.

#### 4. Pathways and Biological Processes
EHBP1 is implicated in several biological processes and signaling pathways, which include:
- **Clathrin-Mediated Endocytosis**: Involvement in the internalization of membrane receptors and the trafficking of vesicles.
- **Actin Cytoskeleton Organization**: Plays a role in the dynamics of the actin cytoskeleton, influencing cellular shape and movement.
- **Insulin Signaling Pathway**: Involvement in the insulin-regulated trafficking of GLUT4 to the plasma membrane in adipocytes, essential for glucose uptake.
- **Vesicle Transport**: Functions as a Rab effector protein, important in various membrane trafficking processes.

### Conclusion
The EHBP1 gene plays a crucial role in endocytic trafficking and actin dynamics, with implications in metabolism and potentially in age-related conditions such as diabetes and cancer. Associated genes and pathways highlight its importance in cellular processes that maintain homeostasis, and ongoing research may further elucidate its role in aging and disease mechanisms.