### SEPTIN1 Gene Overview

**Gene Symbol**: SEPTIN1  
**Gene Family**: Septins, a family of GTPases involved in various cellular processes.

**Function**: The SEPTIN1 gene encodes a protein that forms filamentous structures within the cytoskeleton and plays a crucial role in cytokinesis, which is the process of cell division. The protein is known for its ability to form both homo- and heterooligomeric structures, contributing to cellular morphology and organization. Additionally, SEPTIN1 has been implicated in neurofibrillary tangle formation, notably in the context of Alzheimer's disease.

### 1. Associated Genes
SEPTIN1 has been associated with several other genes and proteins involved in cytoskeletal dynamics, cellular division, and neurodegenerative processes, including:
- **SEPTIN2 and SEPTIN5**: Other members of the septin family that may interact or form complexes with SEPTIN1.
- **MAPT (Microtubule-associated protein tau)**: Tau protein is involved in the formation of neurofibrillary tangles in Alzheimer's disease, linking it to the potential role of SEPTIN1 in neurodegeneration.
- **RHOA**: A key regulator in actin organization that interacts with septin proteins during cytokinesis.

### 2. Aging and Age-Related Diseases
- **Neurodegenerative Disorders**: SEPTIN1's role in the formation of neurofibrillary tangles suggests a connection to Alzheimer's disease, a condition that predominantly affects older adults. Its involvement in the maintenance of cellular morphology and function may implicate its significance in other age-related cognitive decline or neurodegenerative processes.
- **Cytokinesis and Cell Aging**: As a critical component in cell division, altered function of SEPTIN1 or related pathways may influence cellular aging and senescence, potentially impacting tissue regeneration and repair mechanisms, which tend to deteriorate with age.

### 3. Drug Interactions
As of now, there are no specific drugs or drug classes that are directly known to interact with SEPTIN1; however, given its involvement in cellular processes and diseases, research into small molecules that can modulate septin function (either inhibiting or enhancing its activity) could be of interest, especially in the context of drug development for neurodegenerative diseases.

### 4. Pathways and Biological Processes
SEPTIN1 is involved in several critical pathways and biological processes:
- **Cytokinesis**: Essential for the proper division of cells during reproduction.
- **Cell Morphogenesis**: Influences the shape and organization of cells, essential for maintaining the structure of tissues.
- **Cytoskeletal Organization**: Contributes to the dynamics and stabilization of cytoskeletal elements like actin and microtubules.
- **Neurodegenerative Disease Pathways**: Involved in processes leading to the formation of neurofibrillary tangles, primarily associated with Alzheimer's pathology.

### Summary
SEPTIN1 is a multifaceted gene encoding a filament-forming GTPase that plays vital roles in cell division and maintenance of cell structure. As research continues, a clearer understanding of its connections with aging, age-related diseases, and potential therapeutic avenues will likely be uncovered.