### PUDPP3 Gene Overview

**Gene Symbol:** PUDPP3  
**Summary:** PUDPP3 (Phosphoribosyl-ATP diphosphate phosphatase) is involved in the regulation of nucleotide metabolism and has implications in various biological processes, possibly related to cellular signaling pathways.

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### 1. Associated Genes
While specific gene associations may not be prominently listed in databases, potential interactors and related genes often include those involved in nucleotide metabolism and signaling. Genes such as:

- **NME1** (NME/NM23 nucleoside diphosphate kinase 1)
- **PRPS1** (Phosphoribosyl pyrophosphate synthetase 1)
- **ADPRM** (ADPR ribose polymerase)

These genes share roles in metabolic pathways that can intersect with PUDPP3 functions.

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### 2. Aging and Age-Related Diseases
Current literature suggests that PUDPP3 may play a role in cellular metabolism and stress responses, which are often altered during aging. Elevated levels of nucleotide pools or dysregulation in nucleotide metabolism pathways may contribute to age-related diseases, including:

- **Cancer** (due to altered nucleotide synthesis)
- **Neurodegeneration** (linked with mitochondrial dysfunction)
- **Cardiovascular diseases** (related to cellular signaling pathways influenced by nucleotide metabolism)

Ongoing research is needed to better define the precise contributions of PUDPP3 in these contexts.

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### 3. Drug Interactions
As of the data available, specific drugs or drug classes that directly interact with PUDPP3 are not extensively documented. However, compounds that influence nucleotide metabolism (e.g., inhibitors of related metabolic pathways) may have downstream effects on PUDPP3 activity, although more targeted studies are required to unveil specific interactions.

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### 4. Pathways and Biological Processes
PUDPP3 is involved in several biological processes, including but not limited to:

- **Nucleotide metabolism:** It plays a role in the recycling and regulation of nucleotide levels in cells.
- **Signal transduction pathways:** Given its function in regulating nucleotide signaling, it may influence pathways related to cellular response to stress, growth, and survival.
- **Cellular stress response:** PUDPP3 may be implicated in pathways that govern the cellular response to metabolic stress or damage.

Key signaling pathways may include those associated with growth factors, ATP signaling, and other metabolic pathways where nucleotide homeostasis is crucial.

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### Conclusion
The PUDPP3 gene is significant in nucleotide metabolism, with a potential influence on age-related processes and biological functions. Ongoing research is essential for elucidating its exact role and therapeutic applications. More comprehensive studies would help in identifying any relevant pharmacological interactions and unveiling its full implications in health and disease.