### SNORD67 Gene Overview

**Gene Symbol:** SNORD67

**Description:** SNORD67 (Small Nucleolar RNA, C/D Box 67) is a member of the C/D box class of small nucleolar RNAs (snoRNAs) that are primarily involved in the modification of ribosomal RNA (rRNA), specifically guiding the 2’-O-methylation of rRNA and potentially other RNA substrates. This modification is crucial for the proper folding and function of rRNA, which plays a key role in ribosome assembly and function.

### 1. Associated Genes

While specific associations are not typically outlined for snoRNAs, small nucleolar RNAs like SNORD67 are often interconnected with genes involved in ribosome biogenesis and rRNA processing. Some potential genes associated with SNORD67 include:

- **NOP58 (Nucleolar Protein 58)**: A component of the snoRNP complex that might interact with SNORD67 during rRNA modification.
- **FBL (Fibrillarin)**: A protein involved in the modification of snoRNA that may also be associated with mechanistic processes involving SNORD67.
  
Additionally, since snoRNAs can regulate other genes through alternative RNA processing or modification pathways, an extensive list of direct associations would typically involve comprehensive expression and functional studies.

### 2. Aging and Age-Related Diseases

Though direct research linking SNORD67 specifically to aging or age-related diseases is sparse, small nucleolar RNAs, in general, have been implicated in the regulation of gene expression and cellular senescence. Dysregulation of snoRNAs can contribute to:

- **Cancer**: Abnormal expression patterns of various snoRNAs have been observed in different types of cancer, suggesting a role in oncogenesis and tumor progression.
- **Neurodegenerative Disorders**: Some studies have indicated that changes in snoRNA expression profiles may be associated with disorders like Alzheimer’s disease and other forms of dementia, possibly linked to ribosomal dysfunction and the global protein synthesis machinery in aging cells.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes directly known to interact with the SNORD67 gene. However, compounds that modulate the expression of snoRNAs or RNA modifying enzymes could theoretically impact the function of SNORD67 indirectly. For more targeted therapeutic interventions, research into compounds affecting ribosome biogenesis, RNA methylation, or cellular stress responses could provide insight.

### 4. Pathways and Biological Processes

SNORD67 is involved in several biological pathways related to:

- **rRNA Modification**: Facilitating the methylation of specific ribosomal RNA nucleotides.
- **Ribosome Biogenesis**: Contributing to the assembly and function of ribosomes, which is essential for protein synthesis.
- **Cellular Growth and Proliferation**: Given its role in ribosome function, SNORD67 may influence general cellular growth processes.

### Conclusion

SNORD67 is a crucial small nucleolar RNA that plays a significant role in rRNA methylation and ribosome assembly. While specific associations with other genes, age-related diseases, drug interactions, and detailed biological pathways are still areas needing further exploration, its importance in cellular function underscores the role of snoRNAs in development, disease, and cellular aging processes.