### SEPTIN14 Gene Overview

**Gene Symbol**: SEPTIN14  
**Location**: Human Chromosome 8q23.1

**Protein Summary**: The SEPTIN14 gene encodes a member of the septin family of proteins, which are filament-forming GTPases that play key roles in various cellular processes, including cytoskeletal organization, intracellular compartmentalization, and cell division. This specific protein is likely involved in the migration of cortical neurons and the formation of leading processes during embryonic development. Furthermore, it is suggested to play a role in spermiogenesis, particularly in sperm head formation by possibly facilitating the localization of ACTN4—a protein associated with actin filaments.

### 1. Associated Genes
SEPTIN14 interacts with and is often studied in relation to several other genes, including:
- **ACTN4**: Alpha-actinin-4, associated with actin filaments.
- **SEPTIN6**, **SEPTIN7**, **SEPTIN9**, and **SEPTIN11**: Other members of the septin family, which work together in forming complexes.
- **RHOA**: A Rho family GTPase involved in various signaling pathways related to the cytoskeleton.
- **CRMP1**: Collapsin response mediator protein 1, which is involved in neuronal development.

### 2. Aging and Age-Related Diseases
Details specific to SEPTIN14 in the context of aging or age-related diseases are less established than for some other genes. However, abnormal functioning of septins, including SEPTIN14, has been implicated in neurodegenerative diseases. For example:
- *Neurodegeneration*: Variations or dysfunctions in septins may disrupt neuronal migration and may be associated with certain neurodevelopmental disorders.
- *Cancer*: Some septins have been identified as potential biomarkers in cancer development, indicating that SEPTIN14 could also play roles in tumorigenesis.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes that have been directly linked to SEPTIN14. However, potential research into cytoskeletal modulators or developmental biology drugs may yield insights into how medications impact the pathways involving SEPTIN14.

### 4. Pathways and Biological Processes
SEPTIN14 is involved in several biological processes and pathways including:
- **Cytoskeleton Organization**: As a filament-forming GTPase, SEPTIN14 is engaged in the overall structure and dynamics of the cytoskeleton.
- **Neurite Morphogenesis**: Critical in the development and differentiation of neurons.
- **Cell Division**: Participates in organizing the cytoskeleton during mitosis and cytokinesis.
- **Spermiogenesis**: A process specifically linked to male gamete formation and maturation.

#### Additional Processes Include:
- **Regulation of GTPase Activity**: SEPTIN14 may affect GTPase signaling pathways.
- **Cell Migration**: Important for both developmental and possibly pathological processes.

In summary, SEPTIN14 is a significant gene within the SEPTIN family, with diverse roles, particularly in neuronal and reproductive health, while still being an active area of investigation relative to its implications in various biological and pathological contexts.