### ART5 Gene Overview

**Gene Symbol**: ART5  
**Family**: ARG-specific ADP-ribosyltransferase family  

The ART5 gene encodes a protein that participates in post-translational modifications of target proteins by transferring ADP-ribose moieties to specific amino acid residues. This process can regulate the function of the target proteins, potentially influencing various cellular processes.

### 1. Associated Genes
While no specific genes are explicitly mentioned in the summaries from NCBI and UniProt, ART5 may have connections with genes involved in the ADP-ribosylation process, cellular signaling, or stress responses. Possible associated genes may include:

- **PARP family genes (e.g., PARP1)**: Involved in DNA repair and cellular responses to stress, potentially influenced by the ADP-ribosylation state.
- **ADPRT family genes**: Genes that code for various ADP-ribosyltransferases may function in overlapping pathways and biological processes.

### 2. Aging and Age-related Diseases
Research indicates that ADP-ribosylation may be involved in age-related processes and diseases:

- **Cellular Stress Responses**: Dysregulation in ADP-ribosylation pathways, including those mediated by ART5, can contribute to the aging process by affecting cellular stress responses, apoptosis, and senescence.
- **Neurodegenerative Diseases**: Altered ADP-ribosylation patterns have been associated with neurodegenerative diseases, suggesting potential links between ART5 activity and these conditions.
- **Cancer**: ADP-ribosylation has been implicated in cancer cell biology, including proliferation and survival, which may be influenced by ART5 gene expression.

### 3. Known Drug Interactions
While specific drugs directly targeting ART5 may not be well defined, certain classes of drugs and compounds interacting with ADP-ribosylation pathways include:

- **PARP Inhibitors**: Such as Olaparib and Rucaparib, which could theoretically impact ART5 activity indirectly by affecting the broader ADP-ribosylation landscape.
- **Calmodulin inhibitors**: These may influence signaling pathways tied to ADP-ribosylation and subsequently ART5 activity.

### 4. Pathways and Biological Processes
ART5 is involved in various biological processes, which may include:

- **Signal Transduction**: As a regulator of protein function through ADP-ribosylation, ART5 influences various signaling pathways, particularly those associated with stress responses.
- **Cell Proliferation and Survival**: ADP-ribosylation serves as a regulatory mechanism in cellular processes such as mitosis and apoptosis, possibly influenced by ART5.
- **DNA Damage Response**: Given its involvement in modifying proteins linked to DNA repair mechanisms, ART5 may be part of pathways responding to cellular damage and maintaining genome integrity.

### Conclusion
The ART5 gene plays a crucial role in the regulation of protein functions through ADP-ribosylation, with potential implications in aging, age-related diseases, and therapeutic interactions. Further exploration of its molecular pathways could yield insights into its functions and associations with various biological processes.