### ARHGAP36 Gene Overview

**Gene Symbol:** ARHGAP36  
**Function:** ARHGAP36 encodes a protein that functions as a GTPase-activating protein (GAP) for Rho-type GTPases, which are critical regulators of various cellular processes by cycling between an active GTP-bound state and an inactive GDP-bound state. The gene is predicted to play roles in signal transduction and in the regulation of catalytic activity.

### 1. Associated Genes
While specific associations may not be detailed in the provided summaries, ARHGAP36 is part of a larger family of RhoGAPs. Therefore, it may be functionally linked with other Rho-family GTPases like **RHOA, RHOB, RHOC** as well as other GAPs like **ARHGAP1, ARHGAP5**, and **ARHGAP11A**. These proteins often interact in signaling pathways related to cell migration, cytoskeletal dynamics, and other cellular functions.

### 2. Aging and Age-related Diseases
Research on ARHGAP36 in the context of aging or age-related diseases is still emerging. However, studies on RhoGAPs generally have indicated a possible role in cellular senescence and the modulation of signaling pathways relevant to cancer and neurodegenerative diseases. Dysregulation of Rho GTPases, for which ARHGAP36 is a GAP, has been implicated in various conditions, including:

- **Cardiovascular Diseases**: Alterations in Rho signaling have been linked with hypertension and vascular remodeling.
- **Neurodegeneration**: Modulation of Rho-GTPase activity may be involved in neuronal signaling and apoptosis, implicating potential roles in conditions like Alzheimer's disease.

### 3. Drug Interactions
As of the latest information available, specific drugs or drug classes that directly target ARHGAP36 have not been widely identified. However, it may have indirect interactions via the modulation of pathways involving Rho GTPases. Some general drug classes that have been noted to affect Rho GTPase signaling, which ARHGAP36 regulates, can include:

- **Rho-kinase inhibitors**: These drugs target pathways downstream of Rho family GTPases and may indirectly influence the functions of ARHGAP36-mediated signaling.

### 4. Pathways and Biological Processes
ARHGAP36 is implicated in several biological processes and pathways, including:

- **Signal Transduction**: Plays a vital role in the intracellular signaling pathways regulated by Rho GTPases.
- **Cytoskeletal Organization**: Involvement in the regulation of cytoskeletal dynamics, affecting both cell shape and motility.
- **Cell Adhesion and Migration**: Influences processes involved in cell adhesion and migration, which are critical in development and wound healing.
- **Regulation of Neuronal Activity**: Involvement in processes such as synaptic plasticity and neuronal growth, although further investigation is needed in this area.

Overall, ARHGAP36 is an important gene with implications in various cellular processes, and its role in pathology is an area of ongoing investigation. To obtain the most comprehensive insights, further studies focusing on ARHGAP36's interactions, age-related effects, and specific drug targets may be warranted.