The HDGFL3 gene (also known as “Homeobox Domain Containing Gene 3-Like 3”) encodes a protein predicted to function in several cellular activities. Here’s an expanded description based on your queries:

### 1. Associated Genes
While specific genes directly associated with HDGFL3 in literature may vary, studies have indicated that HDGFL3 may share pathways and interactions with genes involved in similar biological processes. These could include genes such as:
- **MAPT** (Microtubule Associated Protein Tau): Involved in microtubule stability, which may overlap with HDGFL3's predicted microtubule-related functions.
- **TP53**: Known as the tumor protein p53, which plays roles in cell cycle regulation and apoptosis.
- **CDK2**: Cyclin-dependent kinase 2, involved in cellCycle regulation and DNA replication.

### 2. Aging and Age-Related Diseases
Current research highlighting HDGFL3 in the context of aging is limited. However, its roles in DNA synthesis and cell proliferation imply potential involvement in age-related processes:
- **Cellular Senescence**: Changes in microtubule dynamics and regulation of cell proliferation can impact senescence, which is observed in aging tissues.
- **Neurodegenerative Diseases**: Given its suggested involvement in neuron projection development, HDGFL3 may also be implicated in age-related neurodegenerative conditions; however, direct links remain to be established.

### 3. Known Drug Interactions
There is currently no specific information regarding direct drug interactions with HDGFL3; however, as a transcription regulator and promoter of cell proliferation, drugs targeting cellular pathways, such as:
- **Chemotherapeutic Agents**: Drugs affecting cell cycle and proliferation may indirectly relate to its function.
- **Microtubule Stabilizers**: Such as Paclitaxel, which affect microtubule dynamics, may have indirect interactions, given HDGFL3's predicted functions.

### 4. Pathways and Biological Processes
HDGFL3 is predicted to participate in several key pathways and biological processes, including:
- **Microtubule Polymerization**: As a regulator of microtubule dynamics, which are critical for cell structure and division.
- **Neuron Projection Development**: Important for neural growth and connectivity.
- **Regulation of Cell Cycle**: Implicated in cell proliferation through effects on DNA synthesis.
- **Developmental Processes**: Potential involvement in various aspects of organism development due to its regulatory roles.

Overall, HDGFL3 appears to play multifaceted roles in cellular processes, particularly in relation to microtubule dynamics, DNA synthesis, and potential implications for growth and development. Future research may further elucidate its functions and associations, especially concerning aging and disease.