### AMFR Gene Overview

**Gene Symbol**: AMFR  
**Entrez Gene ID**: 26993  
**Location**: Chromosome 1 (1q21.3)

The AMFR (Autocrine Motility Factor Receptor) gene encodes a glycosylated transmembrane receptor that plays a role in various cellular processes, primarily through its involvement in tumor motility, protein ubiquitination, and degradation pathways.

### 1. Associated Genes
In addition to the targets mentioned in the summaries (CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2, APOB, HMGCR), AMFR is also associated with the following genes involved in similar or related pathways:

- **UBE2G2**: Ubiquitin-conjugating enzyme, involved in the ubiquitination process alongside AMFR.
- **RNF139**: Another ubiquitin ligase that may interact with AMFR in regulating protein degradation.
- **BAG6**: A component of the BAG6 complex, which is implicated in the ER-associated degradation pathway.
- **TAB3**: Part of the signaling pathways influenced by AMFR, particularly in relation to MAP3K7 activity.

### 2. Aging and Age-Related Diseases
While specific studies linking AMFR directly to aging or age-related diseases are limited, there are some associations worth noting:

- **Somatic Mutations and Aging**: Altered ubiquitination pathways, such as those mediated by AMFR, can influence cellular senescence and the accumulation of damaged proteins over time, which is a hallmark of aging.
- **Cancer**: AMFR's role in tumor invasion and metastasis suggests its potential relevance in age-related cancer progression.
- **Metabolic Disorders**: As AMFR is involved in lipid metabolism through its role in the degradation of key enzymes like HMGCR, it may be implicated in age-related metabolic disorders.

### 3. Drug Interactions
There are no specific drugs or drug classes uniquely known to interact with AMFR reported in the literature. However, as it plays a key role in pathways that manage cell signaling and degradation:

- **Statins**: These drugs, which inhibit HMGCR, might indirectly relate to AMFR's signaling due to roles in cholesterol metabolism and degradation of HMGCR.
- **Proteasome Inhibitors**: Since AMFR is involved in ubiquitin-proteasome degradation pathways, drugs affecting the proteasome might indirectly interact with the pathways that involve AMFR.

### 4. Pathways and Biological Processes
The AMFR gene is involved in a variety of biological processes and pathways, including:

- **Endoplasmic Reticulum-Associated Degradation (ERAD)**: AMFR is a key player in ERAD, facilitating the degradation of misfolded proteins and membrane proteins like HMGCR.
- **Ubiquitin-Proteasome System**: As an E3 ubiquitin ligase, AMFR participates in the ubiquitination of substrates for proteasomal degradation.
- **Wnt Signaling Pathway**: AMFR, along with LMBR1L and UBAC2, negatively regulates canonical Wnt signaling by mediating the degradation of Wnt receptors and the β-catenin transcriptional regulator CTNNB1.
- **NF-kappa-B Signaling Pathway**: It influences NF-kappa-B pathway by controlling the polyubiquitination of TAB3 and other signaling proteins.
- **Cell Migration and Invasion**: Associated with tumor motility via its role in mediating the effects of the autocrine motility factor.

Overall, AMFR is a multifaceted protein with implications in cancer biology, metabolic regulation, protein homeostasis, and potentially the aging process through its various interactions and regulatory functions. Continued research may further clarify its roles in health and disease, particularly in the context of aging and age-related conditions.