**NTMT1 Gene Overview**

The NTMT1 (N-terminal methyltransferase 1) gene encodes an enzyme that plays a vital role in the post-translational modification of proteins through N-terminal methylation. This modification can impact protein stability, localization, and interactions, making it crucial for various cellular processes.

### 1. Associated Genes

In addition to the genes mentioned in the NCBI and UniProt summaries (e.g., KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A, SET), NTMT1 may also be functionally or physically associated with the following genes:

- **NTMT2**: Another methyltransferase that may prime substrates for NTMT1-mediated methylation.
- **CENPA**: While mentioned in the summary, it's worth noting that CENPA is a histone variant critical for centromere function and chromosome segregation.
- **Others**: Potential indirect associations may exist with genes involved in chromosomal stability, cell cycle regulation, and spindle assembly.

### 2. Aging and Age-Related Diseases

Ties between NTMT1 and age-related conditions or aging processes are still under investigation. However, several known implications include:

- **Cancer**: Aberrant regulation of NTMT1 activity or expression may contribute to tumorigenesis via the improper methylation of oncogenes or tumor suppressor genes (e.g., RB1).
- **Neurodegenerative Diseases**: Alterations in methylation patterns are observed in diseases like Alzheimer's disease, though specific direct associations with NTMT1 need further study.
- **Cellular Aging**: Proper methylation regulation by NTMT1 may be essential for maintaining cellular homeostasis and preventing senescence.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes documented to directly interact with NTMT1. However, drugs that affect methylation processes more broadly, such as:

- **S-Adenosylmethionine (SAMe)**: A common methyl donor in biological reactions.
- **Inhibitors of methyltransferases**: For example, drugs that inhibit other methyltransferase enzymes may indirectly impact NTMT1 activity or expression.

Future studies might reveal more focused interactions, especially as therapeutic strategies targeting methyltransferases emerge in cancer treatment.

### 4. Pathways and Biological Processes

NTMT1 is involved in multiple biological pathways and processes, including:

- **Mitosis and Cell Division**: Through its role in N-terminal methylation of RCC1, NTMT1 is critical for normal bipolar spindle formation and chromosome segregation.
- **Protein Methylation**: Specifically, it is part of the broader category of protein modification processes that influence protein-protein interactions and stability.
- **Regulation of Gene Expression**: By modifying transcriptional regulators and factors, NTMT1 may influence gene expression dynamics.
- **Cell Cycle Progression**: Given its involvement in the mitotic process and chromosome dynamics, NTMT1 plays a role in the overall regulation of the cell cycle.

### Summary

The NTMT1 gene encodes a key enzyme in protein N-terminal methylation, influencing critical cellular processes, including mitosis and gene expression regulation. While there is a growing interest in its association with aging and age-related diseases, further research will elucidate its role in these areas, as well as any potential therapeutic implications. Current knowledge of direct drug interactions remains limited, highlighting the potential for future discovery in targeted therapeutic strategies involving NTMT1.