### CPSF7 Gene Overview

**Gene Symbol:** CPSF7  
**Gene Function:** The CPSF7 gene encodes a subunit of the cleavage factor Im (CFIm) complex. It plays a critical role in the cleavage and polyadenylation of pre-mRNAs, necessary for the maturation of pre-mRNAs into functional mRNAs. It acts as an activator within the cleavage and polyadenylation processing machinery, binding to specific nucleotide sequences in the pre-mRNA 3'-end.

### 1. Associated Genes

CPSF7 is part of the CFIm complex, which includes several other associated genes:
- **CPSF1:** Cleavage and Polyadenylation Specificity Factor 1
- **CPSF3:** Cleavage and Polyadenylation Specificity Factor 3
- **CPSF6:** Cleavage and Polyadenylation Specificity Factor 6
- **CPSF2:** Cleavage and Polyadenylation Specificity Factor 2
- **HNRNPD:** Heterogeneous Nuclear Ribonucleoprotein D (also interacts with splicing factors)
- **U2AF1 & U2AF2:** U2 Small Nuclear RNA Auxiliary Factor 1 and 2 (involved in splicing and regulation of polyadenylation)

### 2. Aging or Age-Related Diseases

Recent studies have suggested a role of polyadenylation mechanisms in the regulation of gene expression that may influence aging and age-related diseases, such as:
- **Cancer:** Alternative cleavage and polyadenylation (APA) can affect tumor suppressors and oncogenes, possibly leading to dysregulated expression in aging processes or cancer development.
- **Neurodegenerative Diseases:** Research indicates that dysregulation of pre-mRNA processing, including polyadenylation, may be implicated in diseases like Alzheimer’s and other neurodegenerative disorders.

While direct evidence linking CPSF7 to aging or specific age-related diseases might not be abundantly documented, its fundamental role in RNA processing implicates it in broader cellular aging processes.

### 3. Drug or Drug Class Interactions

As of the latest updates:
- **Specific Drugs:** No specific drugs have been directly documented to target CPSF7; however, drugs that affect mRNA processing or splicing, such as **spliceosome modulators** (e.g., E7107), may indirectly influence the activity of CPSF7.
- **Drug Classes:** Potential interactions exist with small molecule inhibitors that target RNA processing pathways and other transcriptional regulatory mechanisms.

### 4. Pathways and Biological Processes

CPSF7 is notably involved in the following pathways and biological processes:
- **mRNA Splicing:** Interacts with U2AF proteins, linking splicing and polyadenylation.
- **Cleavage and Polyadenylation of Pre-mRNA:** Essential in the correct 3’-end processing of pre-mRNAs.
- **Regulation of Gene Expression:** Modulates the stability and localization of mRNA through alternative polyadenylation.
- **Cellular Response to RNA damage:** May be implicated in cellular responses to stress where RNA stability and turnover are essential.

In summary, CPSF7 is a central player in the regulation of mRNA processing and may have indirect roles in aging and disease through its influence on gene expression. Further studies are needed to fully elucidate the extent of its associations and regulatory roles in health and disease.