The PLS3-AS1 gene, or PLS3 antisense RNA 1, is a long non-coding RNA (lncRNA) that plays regulatory roles in gene expression and may be involved in various biological processes. Here’s a detailed overview based on the requested aspects:

### Overview of PLS3-AS1

- **Gene Symbol**: PLS3-AS1
- **Function**: As a long non-coding RNA, PLS3-AS1 primarily functions in the regulation of transcription and impacts various cellular processes by modulating the expression of neighboring genes or influencing the transcriptional landscape.

### 1. Associated Genes

PLS3-AS1 is in proximity to and potentially regulates neighboring genes, particularly:

- **PLS3**: This gene encodes for Plastin 3, a cytoskeletal protein implicated in cell motility and proliferation. PLS3 primarily acts as a regulator of actin dynamics.
  
Additional research may reveal other associated genes through functional studies or expression analyses.

### 2. Aging and Age-Related Diseases

Current literature highlights potential associations of PLS3-AS1 with aging and age-related diseases:

- **Osteoporosis**: Variants in the PLS3 gene, which is linked to PLS3-AS1, have been implicated in osteoporosis susceptibility. PLS3-AS1 could contribute to the regulation of gene expression pathways affecting bone density.
- **Cellular Senescence**: Non-coding RNAs like PLS3-AS1 may play roles in cellular senescence and age-related cellular changes, although specific direct associations are still being elucidated.

While detailed studies connecting PLS3-AS1 explicitly to aging are limited, its association with PLS3 suggests that it could impact age-related processes through its regulatory functions.

### 3. Drug Interactions

As of now, there is limited information regarding specific drugs or drug classes that directly interact with PLS3-AS1. However, since it is involved in pathways relevant to cellular functions and disease states, it is plausible that therapeutic agents targeting related pathways may indirectly influence its expression or activity. Additional studies focusing on lncRNA interactions with therapeutics are needed for a more comprehensive understanding.

### 4. Pathways and Biological Processes

PLS3-AS1 is involved in several biological processes and pathways, including but not limited to:

- **Regulation of Gene Expression**: As an lncRNA, PLS3-AS1 may modulate transcription of nearby genes (e.g., PLS3).
- **Cytoskeletal Dynamics**: Its association with PLS3 suggests a role in actin dynamics and cell shape regulation.
- **Cell Motility and Proliferation**: Given its relationship with PLS3, it may impact processes linked to cellular movement and growth.

### Summary

PLS3-AS1 is a regulatory lncRNA tied closely to the PLS3 gene, which is known for its role in cytoskeletal dynamics. Though the gene may have implications in age-related conditions like osteoporosis, direct associations with aging and therapeutic interactions require further validation. Its involvement in regulatory processes underscores the importance of lncRNAs in genetic complexity, particularly concerning cellular function and disease mechanisms.