### CCDC116 Gene Overview

**Gene Symbol**: CCDC116  
**Location**: Chromosome 10, with a specific emphasis on being located at the centrosome, which highlights its potential role in cellular organization and function related to microtubule assembly and mitosis.

**Protein Summary**: The CCDC116 gene encodes a protein, and there is one potential isoform mapped to this entry. It is associated with structural roles in cellular components, particularly linked to ciliary function and the centrosome.

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### Associated Genes

Although specific genes associated with CCDC116 were not mentioned in the provided summaries, genes involved in similar functional pathways or genetic networks may include:

1. **CCDC65** - Similar in terms of being associated with ciliary structure and function.
2. **IFT88** - Involved in intraflagellar transport, critical for ciliary assembly.
3. **TCTN1** - Associated with cilia and signaling pathways.
4. **KIF3A** - A kinesin involved in transport mechanisms related to cilia and centrosome dynamics.

### Aging and Age-Related Diseases

The CCDC116 gene may have implications in aging and age-related diseases, particularly due to its involvement in ciliary function, which is known to decline with age. Disruptions in ciliary structure and function have been linked to several age-related diseases such as:

1. **Ciliopathies**: Disorders resulting from dysfunctional cilia, which can impact kidneys, eyes, and the brain, some of which display age-related onset.
2. **Neurodegenerative Diseases**: Alterations in cilia dynamics can be associated with diseases such as Alzheimer’s and Parkinson’s, which exhibit age-related prevalence.

### Drug Interactions

As of October 2023, specific drug interactions for CCDC116 have not been well characterized in publicly available databases. However, it is possible that certain drugs affecting microtubule dynamics (e.g., taxanes that stabilize microtubules) could indirectly affect CCDC116 function due to its role in the centrosome. Further research or specific clinical trials may elucidate clearer interactions.

### Pathways and Biological Processes

CCDC116 is involved in several important biological processes, primarily related to:

1. **Cilium Assembly**: Given the gene's association with the centrosome and ciliary function, CCDC116 likely plays a role in the formation and maintenance of cilia, which are essential for various signaling pathways.
2. **Cell Cycle Regulation**: Linked to centrosomal function, it may participate in processes that govern cellular division and the integrity of the mitotic spindle.
3. **Intracellular Transport**: Through interactions with other centrosomal proteins and cytoskeletal components, CCDC116 may influence the trafficking of organelles and vesicles within the cell.

Overall, CCDC116 appears to be a gene with pivotal roles in cellular architecture and function, with emerging associations to both disease pathology and mechanisms ofaging. Continued research is needed to elucidate its complete range of functional interactions and implications for health and disease.