### RNA5SP135 Gene Overview

**Gene Symbol:** RNA5SP135

RNA5SP135 is a small nucleolar RNA (snoRNA) that is part of the class of RNA molecules involved in guiding the chemical modification of other RNAs, predominantly ribosomal RNA (rRNA). It is often categorized within the broader family of small nucleolar RNAs due to its role in processing and modifying rRNAs.

### 1. Associated Genes
While specific associations of RNA5SP135 with other genes are typically limited, snoRNAs, in general, have been connected to various ribosomal genes and genes implicated in cellular stress responses and ribosomopathies. However, comprehensive lists of associated genes for RNA5SP135 specifically may not be readily available, given its relatively specialized role.   

### 2. Aging and Age-Related Diseases
Current literature predominantly associates snoRNAs with cellular regulation and ribosome biogenesis rather than directly linking RNA5SP135 to aging or age-related diseases. Nevertheless, snoRNAs play general roles in regulating cellular homeostasis, and perturbations in snoRNA expression may influence the pathways leading to age-related diseases such as cancer, neurodegeneration, or cardiovascular diseases. 

Aging processes may impact the expression levels and functional efficacy of RNA5SP135 and other snoRNAs. Furthermore, dysregulation in snoRNA functioning has been implicated in disorders like Alzheimer's disease where ribosomal dysfunction may play a role.

### 3. Drug Interactions
As for direct drug interactions, RNA5SP135 does not have well-documented associations with specific drugs or drug classes. However, because snoRNAs like RNA5SP135 are involved in the post-transcriptional modification of ribosomal RNA, any therapies affecting ribosome biogenesis, such as those used in the treatment of cancers or other proliferative disorders, may indirectly influence the functioning of RNA5SP135.

### 4. Pathways and Biological Processes
RNA5SP135 is primarily involved in:

- **Ribosome Biogenesis:** RNA5SP135 is a component of the machinery responsible for the maturation and modification of rRNA, crucial for the formation of functional ribosomes.
- **Nucleolar Function:** As a snoRNA, it resides within the nucleolus and is involved in the assembly of ribonucleoprotein complexes.
- **Post-transcriptional Modifications:** It may guide methylation or pseudouridylation of specific rRNA residues, affecting ribosomal integrity and function.

### Conclusion
The RNA5SP135 gene represents a vital component in the world of small nucleolar RNAs, serving important functions in ribosome assembly and modification. While its role in aging and disease is less directly defined, continued exploration in this area may yield insight into its potential contributions to ribosomal biogenesis and cellular health.