### UBR4 Gene Overview

- **Gene Symbol**: UBR4
- **Protein Function**: UBR4 encodes an E3 ubiquitin-protein ligase that plays a crucial role in the ubiquitin-proteasome system, particularly through the N-end rule pathway. It recognizes proteins with destabilizing N-terminal residues, leading to their ubiquitination and degradation.

#### 1. Associated Genes

While the summaries provided do not explicitly detail other genes associated with UBR4, it is involved in various pathways and processes that include interaction with several genes/proteins such as:
- **FAK (Focal Adhesion Kinase)**: Involved in cellular signaling and response to the extracellular matrix, where UBR4 may regulate its activation.
- **ACLY (ATP Citrate Lyase)**: Mediated ubiquitination leading to the degradation of ACLY implicates UBR4 in metabolic processes.
- **Calmodulin**: Involved in calcium signaling and is an interaction partner in the cytoplasm.
- **Calmodulin-dependent proteins**: Due to UBR4's calmodulin interactions, it may indirectly associate with other calmodulin-dependent signaling proteins.

#### 2. Aging and Age-related Diseases

While specific research directly linking UBR4 to aging has not been extensively documented, its roles in cellular processes often tied to aging pathways warrant consideration:

- **Cell Cycle Regulation**: As UBR4 interacts with the retinoblastoma protein, which is crucial in cell cycle control, its function may impact age-related cellular senescence.
- **Cancer**: UBR4's involvement with the HPV type 16 E7 oncoprotein indicates a role in oncogenesis, which has implications in aging as cancer risk generally increases with age.
- **Metabolism and Stress Response**: Its regulation of ACLY may influence metabolic homeostasis, which is often disrupted in age-related diseases like obesity and diabetes.

#### 3. Drug Interactions

As of the last training data until October 2023, specific drugs or drug classes directly interacting with UBR4 are not well documented. However, considering its role in protein degradation and cellular signaling, potential interactions may emerge as follows:

- **Proteasome Inhibitors**: Drugs targeting the proteasome system, such as bortezomib, could indirectly affect UBR4's function by altering the ubiquitin-proteasome pathway overall.
- **Calmodulin Inhibitors**: Since UBR4 interacts with calmodulin, drugs affecting calcium signaling might influence its activity.
- **Antineoplastic Agents**: Given UBR4’s role in cancer biology, agents targeting pathways related to dysfunctional ubiquitination and degradation may indirectly relate to UBR4's function.

#### 4. Pathways and Biological Processes

UBR4 is associated with several biological processes and pathways, some of which include:

- **Ubiquitin-Proteasome Pathway**: Central to protein homeostasis and regulated degradation of proteins.
- **N-end Rule Pathway**: Specific to recognizing and degrading proteins based on their N-terminal residues.
- **Integrin Signaling Pathway**: Involved in cell adhesion and signaling mechanisms in response to the extracellular environment.
- **Cytoskeletal Organization**: Forming meshwork structures with clathrin, UBR4 is integral to cytoskeletal dynamics and function.
- **Cell Migration and Adhesion**: Participating in processes critical for tissue regeneration and morphogenesis.

Overall, UBR4 is a multifunctional protein important in several cellular processes, with intersecting roles in cancer biology, metabolic pathways, and potentially aging-related mechanisms. Further studies would be beneficial to understand deeper implications of UBR4 in aging and age-associated diseases.