### SLC10A2 Gene Overview

#### Basic Information
- **Gene Symbol:** SLC10A2
- **Function:** Sodium/bile acid cotransporter primarily responsible for the uptake of bile acids in the distal ileum, contributing to cholesterol homeostasis.

### 1. Associated Genes
While the provided summaries mention the Na⁺-taurocholate cotransporting polypeptide (NTCP), organic solute transporter (OST), and bile salt export pump (BSEP), other genes may also be associated or interact with SLC10A2 include:
- **SLC10A1:** Another sodium-dependent bile acid transporter that works in conjunction with SLC10A2.
- **ABCB11:** Bile salt export pump involved in the transport of bile acids into the bile.
- **SLC22A4:** Organic cation transporters which may interact with bile acid transport processes.

### 2. Aging and Age-Related Diseases
Research has indicated that improper functioning of the SLC10A2 gene may contribute to age-related conditions such as:
- **Cholesterol-related disorders:** Impaired bile acid recycling can influence lipid metabolism and increase the risk for conditions such as atherosclerosis, which is more prevalent with aging.
- **Non-alcoholic fatty liver disease (NAFLD):** Age-related changes in bile acid homeostasis can predispose individuals to liver diseases.

In older adults, there is increased susceptibility to bile acid malabsorption, potentially leading to nutritional deficiencies and gastrointestinal symptoms, which can worsen alongside the aging process.

### 3. Drugs and Drug Classes
While no specific drugs directly target SLC10A2, its function may be influenced by:
- **Bile acid sequestrants:** Such as colesevelam, which may impact the enterohepatic recirculation of bile acids and, indirectly, the activity of SLC10A2.
- **Cholesterol-lowering medications:** Statins and other lipid-altering drugs may have indirect effects due to the gene’s role in cholesterol homeostasis.

### 4. Pathways and Biological Processes
SLC10A2 is involved in several important biological pathways and processes:
- **Bile Acid Metabolism:** Acts in the enterohepatic circulation of bile acids, ensuring efficient recycling from the intestine to the liver.
- **Cholesterol Metabolism:** Participates in the regulation of cholesterol levels by facilitating bile acid reabsorption.
- **Transport Processes:** Contributes to sodium ion transport and active transport mechanisms in the intestine and kidneys.
- **Homeostasis Maintenance:** Plays a role in maintaining the balance of bile acids and cholesterol levels within the body, crucial for digestive health and metabolic processes.

The gene is a critical component in the metabolism of lipids and plays a significant role in gastrointestinal health and nutrient absorption. Understanding the function of SLC10A2 can yield insights into various metabolic disorders and their connection with aging.