### KLHDC8B Gene Overview

**Symbol**: KLHDC8B  
**Function**: This gene encodes a protein that has a unique beta-propeller structure formed by kelch domains, which mediates protein-protein interactions. It plays a significant role in essential cellular processes, particularly in cytokinesis and maintaining chromosomal stability during cell division.

### 1. Associated Genes
KLHDC8B may interact or be associated with various genes, particularly those involved in cell division, chromosomal stability, and oncogenesis. Some examples of such genes include:

- **TP53**: A critical tumor suppressor involved in cell cycle regulation and apoptosis.
- **BRCA1/BRCA2**: Genes involved in DNA repair mechanisms; mutations can lead to increased cancer risk.
- **AURKB**: Aurora kinase B, which is essential for chromosome segregation during mitosis.
- **MKLP1**: A protein involved in the late stages of cytokinesis.

It’s important to note that many of these associations might depend on the context of studies related to cancer research, particularly in the context of Hodgkin lymphoma.

### 2. Aging and Age-Related Diseases
Research on KLHDC8B's involvement in aging or age-related diseases is relatively limited. However, due to its crucial role in maintaining chromosomal stability and preventing aneuploidy, its dysfunction could theoretically contribute to age-related diseases or an increase in cancer susceptibility as cellular mechanisms fail with aging. The accumulation of mitotic errors and impaired cytokinesis can lead to genomic instability, which is a hallmark of many age-related disorders, including cancer.

### 3. Drug Interactions
As of the latest information until October 2023, there are no specific drug interactions directly associated with KLHDC8B. However, since it plays a role in cancer biology, it may be indirectly influenced by chemotherapeutic agents targeting cellular pathways involved in mitotic regulation. Drugs that target proteins associated with cell division or mitotic processes might interact with KLHDC8B's functions. Examples of these drug classes include:

- **Antineoplastic agents**: Such as taxanes (e.g., paclitaxel) and vinca alkaloids (e.g., vincristine) which disrupt microtubule function, therefore affecting mitosis.

### 4. Pathways and Biological Processes
KLHDC8B is involved in several key pathways and biological processes, including:

- **Cytokinesis**: The physical process of cell division, particularly ensuring proper separation of daughter cells.
- **Cell Cycle Regulation**: Involved in the transition through various stages of the cell cycle, ensuring chromosomal integrity.
- **Chromosomal Stability**: Helps prevent aneuploidy and maintains genomic integrity during cell division.
- **Mitotic Error Correction**: Plays a protective role against errors during mitosis, including centrosomal amplification and the formation of micronuclei.
- **Midbody Formation**: Involved in the structures formed during the final stages of cell division (i.e., the midbody) that lead to the abscission of daughter cells.

In conclusion, KLHDC8B is an important gene implicated in essential cell division processes and potentially in oncogenesis, particularly in relation to Hodgkin lymphoma. Further research may provide more insights into its role in aging and identify specific drug interactions.