### SEMA3E Gene Overview

**Gene Symbol:** SEMA3E  
**Gene Type:** Protein-coding  
**Location:** Human chromosome 7 (7q21.11)

#### General Function
SEMA3E is a member of the semaphorin family, which includes proteins that play critical roles in axon guidance and cellular signaling. The encoded protein is known for its involvement in the reorganization of the actin cytoskeleton, modulation of cell adhesion, and regulation of angiogenesis during both embryonic development and postnatal life. The SEMA3E protein binds to receptors such as plexins, particularly PLXND1, facilitating various signaling pathways essential for vascular and neuronal development.

### 1. Associated Genes
SEMA3E has functional associations with several other genes, although many specifics may depend on individual contexts and studies. Some notable associated genes include:
- **PLXND1 (Plexin D1)**: A primary receptor for SEMA3E involved in its signaling.
- **VEGFA (Vascular Endothelial Growth Factor A)**: Influences angiogenesis and can be affected by SEMA3E signaling.
- **CFL1 (Cofilin 1)**: Involved in actin filament dynamics, potentially interacting in processes regulated by SEMA3E.
- **RAP1A (RAS-related protein Rap-1A)**: May have roles in cell adhesion and signaling pathways impacted by SEMA3E.

### 2. Aging and Age-Related Diseases
Research suggests that SEMA3E may be implicated in age-related diseases primarily due to its role in angiogenesis and neural development:
- **Neurological disorders**: The SEMA3E signaling pathway has been studied in the context of neurodegenerative diseases such as Alzheimer's disease, where impaired synaptic formation and maintenance is a concern.
- **Vascular diseases**: Ineffective regulation of angiogenesis can contribute to age-related conditions such as atherosclerosis and retinopathy.

### 3. Drug Interactions
As of now, there are no specific drugs that directly target SEMA3E itself, but certain drug classes may modulate pathways influenced by SEMA3E:
- **Angiogenesis inhibitors**: Such as anti-VEGF agents could indirectly affect the pathways SEMA3E is involved in, impacting tumor growth and treatment.
- **Neuroprotective agents**: Some compounds studied in neurodegenerative settings may modulate semaphorin signaling pathways.

### 4. Involved Pathways and Biological Processes
**Biological Processes:**
- **Angiogenesis**: SEMA3E is known to regulate both the initiation and remodeling of blood vessels.
- **Neuronal development**: Plays a crucial role in axon guidance and synapse formation.
- **Cell adhesion**: Impacts the dynamics of focal adhesion and cell migration.
  
**Pathways:**
- **Semaphorin-plexin signaling**: A key pathway that includes SEMA3E in regulating cell communication and guidance.
- **VEGF signaling pathway**: SEMA3E has been implicated in modulating this pathway affecting angiogenesis.
- **Actin cytoskeleton organization**: Engaging pathways that re-organize the cytoskeleton leading to cellular responses.

### Conclusion
SEMA3E is an essential player in various physiological processes, particularly in neuronal development and angiogenesis. Its nuanced roles suggest potential implications in both developmental biology and the pathology of age-related diseases. Further studies are needed to establish its exact mechanisms and how it can be a therapeutic target for such conditions.