### RNF223 Gene Overview

**Gene Symbol:** RNF223  
**Alternative Names:** None specifically mentioned  

**Predicted Functions:**  
The RNF223 gene is predicted to have metal ion binding activity and to be an integral component of the membrane, indicating that it may play a role in cellular structure and signaling through the modulation of metal ion concentrations.

### Associated Genes
While specific genes associated with RNF223 were not mentioned in the provided summaries, related genes can often be identified through various methods, such as co-expression analysis or functional pathways. In studies involving metal ion binding and signaling pathways, genes encoding metal transporters or those involved in cellular stress responses may be associated with RNF223. However, specific names would require further literature exploration or interaction network analysis.

### Aging and Age-Related Diseases
As of the current understanding, there may be limited direct studies linking RNF223 with aging or age-related diseases such as Alzheimer's or cardiovascular diseases. However, given its predicted role in metal ion binding, one might hypothesize a potential involvement in neurodegenerative diseases where metal ion dysregulation is a noted factor. Detailed investigations will be necessary to substantiate these claims.

### Drug Interactions
Currently, there is no extensive, readily available information regarding specific drugs or drug classes that directly interact with RNF223. Potential interactions could be mined from databases such as DrugBank or STITCH, but comprehensive investigations from experimental assays or clinical studies would provide more accurate biochemical interactions.

### Pathways and Biological Processes
RNF223 is associated with several critical biological processes:

1. **Metal Ion Homeostasis**: Involvement in the maintenance and regulation of intracellular metal ion levels, possibly influencing metal-mediated signaling pathways.
2. **Cell Signaling**: Given its predicted membrane localization, RNF223 might partake in signal transduction pathways that utilize metal ions as secondary messengers.
3. **Membrane Integrity**: As an integral component of the membrane, it may contribute to maintaining cellular structure and integrity.

### Summary
Overall, the RNF223 gene's functional annotations suggest it might play roles in cellular homeostasis and signaling mediated by metal ions. To enrich our understanding of RNF223, further experimental data and literature reviews are needed to clarify its interactions, biological significance, and implications in aging or disease contexts.