### Gene Overview: RASSF1-AS1

**Gene Symbol:** RASSF1-AS1  
**NCBI Entrez Gene ID:** 80113  
**UniProt ID:** Q6P1F0

**Description:**  
RASSF1-AS1 (RASSF1 Antisense RNA 1) is a long non-coding RNA that is considered to have regulatory roles in cancer biology and other cellular processes. It is involved in various signaling pathways and has been implicated in the modulation of gene expression, particularly in the context of tumor suppression and cell growth regulation.

### 1. Associated Genes
While RASSF1-AS1 may influence the expression or activity of several genes due to its regulatory role, it is particularly associated with the following genes:
- **RASSF1**: The primary associated gene, involved in apoptotic signaling pathways and tumor suppression.
- **TP53**: Often influences stress response and cell cycle regulation.
- **CDKN1A**: A cyclin-dependent kinase inhibitor associated with cell cycle regulation and senescence pathways.

### 2. Aging and Age-Related Diseases
Research indicates a potential role of RASSF1-AS1 in aging and age-related diseases:
- **Cancer**: Aberrant expression of RASSF1-AS1 has been observed in various cancers. Tumor suppressive functions may decline with age, potentially thereby increasing susceptibility to malignancies.
- **Cellular Senescence**: Altered expression of long non-coding RNAs like RASSF1-AS1 is often noted in aging-related cellular senescence.
- **Neurological Disorders**: There is some emerging evidence suggesting associations with neurodegenerative diseases, though it is an area of ongoing research.

### 3. Drug Interactions
Specific drugs or drug classes that directly interact with RASSF1-AS1 have not been definitively established. However, recognizing its role in tumor suppression:
- **Chemotherapeutic agents**: Since RASSF1-AS1 is involved in cancer pathways, treatments targeting proliferative pathways (e.g., doxorubicin or paclitaxel) may indirectly affect its expression or functional dynamics.
- **Targeted Therapies**: Emerging therapies focused on reactivating tumor suppressor genes might affect RASSF1 and, by extension, RASSF1-AS1's regulation.

### 4. Pathways and Biological Processes
RASSF1-AS1 is involved in several important biological pathways, including:
- **Tumor Suppression Pathways**: Its association with RASSF1 suggests involvement in pathways that control cell cycle and apoptosis.
- **Cell Growth Regulation**: Influences signaling pathways related to cell proliferation, such as the Ras-MAPK pathway.
- **Epithelial-to-Mesenchymal Transition (EMT)**: Involved in processes targeted during tumor metastasis and the regulation of RNA networks in cancer.

### Summary
RASSF1-AS1 serves as a regulatory long non-coding RNA with implications in cancer biology, aging, and cellular processes. Further research is necessary to elucidate detailed mechanisms, particularly regarding its roles in aging and therapeutic interactions. Given its function, RASSF1-AS1 could provide potential insights into therapeutic strategies targeting age-related diseases and cancers.

For the most current and specific details regarding RASSF1-AS1, further literature searches and updates in biomedical databases are recommended, as new findings may have emerged since the last data cutoff.