### GPBP1 Gene Overview

**Gene Symbol**: GPBP1  
**Full Name**: GC-rich promoter-binding protein 1  
**Location**: Human chromosome 14 (14q24.3)

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### 1. Associated Genes

While the NCBI and UniProt summaries do not mention specific associated genes, GPBP1 has been implicated in pathways related to vascular health and inflammation, which may connect it to various other genes involved in these processes, including:

- **SRF (Serum Response Factor)**: A transcription factor involved in smooth muscle cell differentiation and vascular development.
- **MYH9 (Myosin Heavy Chain 9)**: Associated with smooth muscle cell function and migration.
- **TNF (Tumor Necrosis Factor)**: Involved in systemic inflammation and a signaling molecule in many vascular diseases.

### 2. Aging and Age-Related Diseases

GPBP1 has been linked to atherosclerosis, and since this condition is closely associated with aging, the presence of GPBP1 may have implications in age-related vascular diseases. Additionally, changes in its expression levels may contribute to cellular senescence and dysfunction that are characteristic features of aging.

- **Atherosclerosis**: GPBP1 is involved in the transcriptional regulation of genes that play roles in lipid metabolism and inflammatory responses, suggesting a pathophysiological role in the progression of atherosclerosis with age. 
- **Cardiovascular Diseases**: Given its vascular smooth muscle cell-specific expression, it may also have ramifications in other cardiovascular conditions that are exacerbated by aging.

### 3. Drug Interactions

As of the latest data available, there are no direct drugs or drug classes specifically known to interact with GPBP1. However, since it is implicated in atherosclerosis and vascular function, drugs commonly used for cardiovascular health, such as statins, may have secondary interactions with GPBP1 through their impact on vascular smooth muscle cells and inflammation.

### 4. Pathways and Biological Processes

GPBP1 is involved in various biological processes and pathways, including:

- **Transcription Regulation**: Functions as a GC-rich promoter-specific transactivating transcription factor, suggesting its role in gene expression and regulation.
- **Vascular Development**: Plays a role in the differentiation and proliferation of vascular smooth muscle cells.
- **Atherosclerosis Pathway**: Directly linked to the biological pathway involved in the development and progression of atherosclerosis.
- **Apoptotic Processes**: May be involved in processes that govern cell survival and apoptosis in vascular tissues.

### Conclusion

GPBP1 is a significant gene with a specialized role in vascular smooth muscle function and the regulation of transcriptional activity through GC-rich promoter binding. Its implications in aging, atherosclerosis, and cardiovascular disease underscore its importance in vascular biology and potential therapeutic targets in age-related diseases. Further studies are essential to fully elucidate its interactions and regulatory networks.