### GPR183 Gene Overview

**Gene Symbol**: GPR183  
**Location**: Chromosome 13 (specific location varies by species)  
**Gene Type**: Protein-coding gene encoding a G protein-coupled receptor.  

GPR183, also known as Epstein-Barr virus-induced gene 2 (EBI2), plays a key role in the immune response, particularly within lymphocytes. It is activated upon Epstein-Barr virus infection and is primarily expressed in B cells and certain dendritic cells. 

### 1. Associated Genes

While GPR183 itself has many interactions, it is primarily associated with the following genes:

- **CXCR5**: As mentioned, GPR183 collaborates with CXCR5 to mediate B-cell migration and positioning during immune responses.
- **IL-10**: GPR183 may indirectly influence the IL-10 signaling pathway, significant in regulatory T-cell functions and inflammatory responses.
- **CD4**: GPR183's interaction with CD4+ T-cells facilitates the migration of and communication with B-cells in lymphoid tissues.
- **CXCL13**: The chemokine CXCL13 binds to CXCR5, and GPR183 is suggested to facilitate this interaction, influencing the localization of B-cells.

### 2. Aging and Age-Related Diseases

Currently, minimal direct association exists linking GPR183 to aging or age-related diseases explicitly; however, its role in immune system regulation may have indirect implications:

- **Age-Related Immune Dysfunction**: Changes in GPR183 signaling could affect the overall migratory capacity of B-cells and T-cells in the aging immune system, contributing to reduced efficacy in immune responses observed in elderly individuals.
- **Autoimmune Diseases**: GPR183 has been implicated in certain autoimmune diseases, affecting aged populations more prominently (potentially as a function of changing immune responsiveness and inflammation). 

### 3. Drug Interactions

As of the latest updates, no specific drugs have been conclusively identified as targeting GPR183 directly. However, certain compounds and drug classes may impact its signaling pathway indirectly:

- **Immunosuppressants**: General immunomodulatory treatments may influence pathways involving GPR183 due to its role in immune responses.
- **Ligands**: Identified ligands like oxysterols (notably 7-alpha,25-dihydroxycholesterol) are essential for GPR183 activation and expression, though these are not classified as traditional drugs.

### 4. Involved Pathways and Biological Processes

GPR183 is implicated in several pathways and processes:

- **Chemokine Signaling Pathway**: Mediates the migration of immune cells, particularly B-cells and dendritic cells.
- **B Cell Receptor Signaling Pathway**: GPR183 influences B-cell movement during immune response coordination.
- **Antigen Processing and Presentation**: Positively influences T-cell activation by positioning activated cells appropriately in lymph nodes.
- **Inflammation and Immune Response**: Participates in the regulation and positioning of immune cells during inflammation and response to pathogens.

In summary, GPR183 is a vital component of the immune system, primarily functioning in the positioning and migratory responses of B-cells, T-cells, and dendritic cells. Its expression and function could have meaningful implications for health concerning immune response efficacy, particularly in aging and autoimmune contexts. Further research may elucidate the direct connections and therapeutic uses related to GPR183.