### THOC3 Gene Overview
**Gene Symbol:** THOC3  
**Location:** Human chromosome 6, band p21.32

The THOC3 gene encodes a protein that is an integral component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex. This complex is crucial for coupling mRNA transcription, processing, and nuclear export, particularly for spliced and polyadenylated mRNA. THOC3 specifically associates with spliced mRNAs, playing a critical role in mRNA export through the TAP/NFX1 pathway.

### 1. Associated Genes
While the summaries did not list associated genes, THOC3 is functionally related to several other genes involved in the transcription and export processes. These may include:

- **THOC1**: Another component of the THO complex, which is involved in similar transcription and export mechanisms.
- **THOC4 and THOC5**: Additional members of the THO complex that play roles in transcription elongation and mRNA export.
- **NXF1 (Nuclear RNA Export Factor 1)**: Part of the mRNA export pathway that interacts with components of the TREX complex.

### 2. Aging and Age-Related Diseases
As of my last knowledge update in October 2023, specific studies linking THOC3 directly to aging or age-related diseases have not been prominent. However, the role of THOC3 in mRNA export and cell differentiation suggests potential implications in cellular aging processes. Dysregulation of mRNA processing and export can be associated with various diseases, including neurodegeneration, cancer, and other age-related pathologies. 

### 3. Drug and Drug Class Interactions
Direct interactions between drugs and the THOC3 protein have not been extensively documented. However, given its role in mRNA processing and export, it may interact indirectly with drugs that target RNA processing or gene expression pathways. Some drugs classically known to modulate RNA metabolism (such as certain antiviral agents that target mRNA synthesis) may have secondary effects on the THOC complex, although specific drugs interacting directly with THOC3 are not well characterized.

### 4. Pathways and Biological Processes
THOC3 is involved in several biological processes and pathways:

- **mRNA Processing**: Facilitates the maturation of mRNA following transcription.
- **RNA Export**: Assists in the transport of mRNA from the nucleus to the cytoplasm.
- **Regulation of Transcription**: Possibly involved in transcriptional elongation and regulation of gene expression.
- **Cell Differentiation and Development**: Based on animal models, THOC3 might play roles in developmental processes.
- **HIV and KSHV Biology**: The TREX complex involving THOC3 is essential in the context of certain viruses (e.g., KSHV, HIV), impacting viral RNA export and production.

### Summary
THOC3 is an essential player in the nuclear processes of mRNA maturation and export, with broader implications in gene regulation, development, and potentially aging-related mechanisms. Understanding the precise interactions and pathways of THOC3 continues to be a topic of investigation in bioinformatics and gene studies.

### References
Further research articles should be consulted to explore the latest findings regarding THOC3 and its functional implications in specific diseases and biological pathways.