### TTLL12 Gene Overview

Gene Symbol: **TTLL12**

**Functions:**
- TTLL12 encodes a protein that possesses H4K20me3 modified histone binding activity and tubulin binding activity.
- It plays a role in negatively regulating type I interferon-mediated signaling pathways and in the regulation of the mitotic cell cycle.
- Primarily localized in the cytoplasm, TTLL12 is involved in the post-translational modifications of tubulin and histone proteins.
- The protein negatively regulates the detyrosination of tubulin's C-terminus and polyglutamylation of glutamate residues.
- TTLL12 also influences histone H4 trimethylation at 'Lys-20' (H4K20me3), indirectly promoting this post-translational modification.
- It plays a vital role in mitotic processes and maintaining chromosome number stability.
- During RNA virus-mediated infections, TTLL12 negatively regulates the RIG-I pathway by preventing the binding of MAVS to TBK1 and IKBKE.

### Associated Genes
TTLL12 has been linked to several other genes involved in similar biological pathways, including but not limited to:
- **MAVS** (Mitochondrial antiviral signaling protein): Interaction affects viral signaling pathways.
- **TBK1** (TANK-binding kinase 1): Plays a role in antiviral defense and autoinflammatory diseases.
- **IKBKE** (Inhibitor of nuclear factor kappa B kinase subunit epsilon): Involved in inflammation and cancer pathways.
- **DDX58** (Dead box helicase 58): A gene that plays a critical role in the immune response.

### Aging and Age-Related Diseases
There are currently no direct studies linking TTLL12 explicitly to aging or age-related diseases. However, given its roles in cellular processes such as mitotic regulation and response to viral infections, alterations in TTLL12 expression or function could hypothetically impact aging processes. In general, the regulation of protein modifications that TTLL12 influences may contribute to age-related cellular dysfunctions, particularly in tissues impacted by chronic inflammation or cancer.

### Drug Interactions
Currently, there are no specific drugs or drug classes widely reported that directly interact with TTLL12. However, its involvement in regulatory pathways suggests that targeting the pathways impacting TTLL12 (such as antiviral therapies or mitotic regulators) might provide indirect therapeutic avenues.

### Biological Pathways and Processes
TTLL12 is involved in various biological pathways, including:
- **Microtubule dynamics**: Regulation of tubulin post-translational modifications affects the cytoskeleton's stability and function.
- **Histone modification pathways**: Involvement in the regulation of chromatin structure and gene expression via histone methylation.
- **Interferon signaling pathways**: Negative regulation of type I interferons aligns with antiviral responses.
- **Cell cycle regulation**: Implications in proper progression through the mitotic phases, which is crucial for maintaining genomic integrity.

### Conclusion
TTLL12 is an important gene involved in mitotic regulation, tubulin modifications, and antiviral responses. While it has significant roles in cellular processes and potential links to disease mechanisms, further research is needed to fully elucidate its functional implications in aging and drug interactions.