### Overview of CPQ Gene
- **Gene Symbol:** CPQ
- **Gene Function:** The CPQ gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein primarily functions as a carboxypeptidase that hydrolyzes dipeptides with unsubstituted terminals, facilitating their conversion into amino acids. One significant role of this enzyme is involved in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor, which is crucial in thyroid hormone regulation.

### 1. Associated Genes
The CPQ gene may be functionally linked or associated with several other genes involved in peptide metabolism, thyroid function, or general metabolic pathways. Although specific genes are not often highlighted in summarized databases, here are some genes known to be functionally related:
- **TPO (Thyroid Peroxidase)**: Involved in thyroid hormone synthesis.
- **TG (Thyroglobulin)**: The precursor of thyroid hormones, which CPQ may help process by cleaving it.
- **ACE (Angiotensin-Converting Enzyme)**: Another peptidase involved in the metabolism of circulating peptides.
- **DPP4 (Dipeptidyl Peptidase 4)**: Involved in peptide metabolism and immune response, although not directly related, it functions in a parallel pathway of peptide hydrolysis.

### 2. Aging and Age-Related Diseases
- **Aging:** The role of CPQ in hormone release, specifically thyroxine, can be crucial in metabolic regulation during aging. Thyroid hormones significantly influence metabolic rates, and alterations in peptide processing could contribute to age-related changes in metabolism.
- **Age-Related Diseases:** Dysregulation of thyroid hormones is implicated in various age-related diseases such as hypothyroidism and associated conditions like cardiovascular diseases, which may correlate to altered CPQ expression or activity. Research exploring the relationship between CPQ and neurodegenerative diseases such as Alzheimer's could also be significant, given the role of peptides and hormones in cognitive function.

### 3. Known Drug Interactions
While specific drugs directly targeting CPQ are not prominently featured in common databases, the enzyme's involvement in peptide metabolism suggests potential interactions with:
- **Angiotensin II Receptor Blockers (ARBs)**: Drugs such as losartan may influence peptide levels in the bloodstream.
- **ACE Inhibitors**: Agents like lisinopril can impact numerous peptide pathways, including those in which CPQ may be involved.
- **Thyroid Hormone Medications**: Levothyroxine could indirectly affect CPQ activity given its role in thyroid function.

### 4. Pathways and Biological Processes
The CPQ gene is implicated in several critical biological pathways and processes:
- **Thyroid hormone synthesis**: By processing thyroglobulin to release thyroxine.
- **Peptide metabolism**: Participating in the degradation of circulating peptides, which can affect various signaling pathways.
- **Regulation of blood pressure**: Due to its relationship with angiotensin peptides and potential interactions within the renin-angiotensin system.
- **Nutrient absorption and metabolism**: Contributing to the breakdown and utilization of dietary proteins.

### Conclusion
The CPQ gene plays a multifaceted role in metabolic peptide processing, particularly within the context of thyroid hormone regulation. Its implications in aging, potential drug interactions, and associations with other genes highlight its significance in both fundamental biology and clinical contexts. Further research may illuminate more direct associations with various diseases, especially related to metabolic and hormonal balance in aging populations.