### NAA60 Gene Overview

**Gene Symbol:** NAA60  
**Location:** The NAA60 gene encodes an enzyme that functions primarily in the Golgi apparatus, where it is involved in the N-terminal acetylation of free proteins and transmembrane proteins, impacting key biological processes such as chromatin assembly and chromosome integrity.

### 1. Associated Genes

While NAA60 is primarily studied on its own, it may show interactions with several other genes involved in similar processes, particularly those related to histone modification and chromatin structure. Some associated genes include:

- **NAA10**: NAA60 and NAA10 belong to the N-terminal acetyltransferase family, which is involved in protein modification.
- **HIST1H4A** and **HIST3H3**: As NAA60 may also exhibit histone acetyltransferase activity, genes encoding histones could be functionally related.
- **KAT2A (GCN5)** and **KAT2B (PCAF)**: These genes encode lysine acetyltransferases that are also involved in histone modifications and could interact with NAA60 in chromatin regulation.

### 2. Aging and Age-related Diseases

The NAA60 gene's role in chromatin integrity and segregation during cell division suggests potential connections to aging and age-related diseases, though research is limited. Its dysfunction may impact genomic stability, which is known to contribute to cancer and other age-associated pathologies. Altered acetylation states of proteins can influence cellular aging mechanisms, particularly in stem cell function and maintenance. However, specific studies directly linking NAA60 to aging or age-related diseases are currently sparse and would benefit from further investigation.

### 3. Drug Interactions

As of the latest update in October 2023, there are no well-established drug interactions specifically targeting the NAA60 gene or its encoded protein. However, because it functions in protein acetylation, compounds affecting histone acetylation (such as HDAC inhibitors, e.g., Vorinostat and Romidepsin) might indirectly influence NAA60's activity or pathways in which it is involved.

### 4. Pathways and Biological Processes

NAA60 is implicated in several biological processes and pathways:

- **N-terminal Acetylation**: This is the main enzymatic activity of NAA60, essential for the modification of proteins that impacts their stability and function.
- **Chromatin Assembly and Integrity**: NAA60's role in histone modification and chromatin structure plays a crucial part in DNA replication and repair.
- **Cell Cycle Regulation**: NAA60 is necessary for normal chromosomal segregation during anaphase, implicating it in the proper progression of the cell cycle.
- **Transmembrane Protein Function**: By mediating acetylation of cytosolic N-termini of transmembrane proteins, NAA60 may influence signaling pathways and cellular communication.

**Note:** Further research may reveal additional roles and interactions of NAA60 in various biological contexts, including development, immune responses, and disease models.