### DDX52 Gene Overview

The **DDX52** gene encodes a member of the DEAD-box family of RNA helicases, which are characterized by the presence of a conserved DEAH (Asp-Glu-Ala-His) motif. This gene plays a crucial role in ribosome biogenesis and is involved in the maturation of small subunit ribosomal RNA (SSU-rRNA).

#### 1. Associated Genes
Some genes that have been identified as associated with DDX52, in the context of ribosome biogenesis and translational regulation, include:
- **GTPBP4**: A GTP-binding protein involved in ribosome biogenesis.
- **RPS19**: A ribosomal protein associated with ribosome assembly.
- **DDX1**: Another DEAD-box RNA helicase that has been implicated in the regulation of ribosomal RNA processing.
- **U6**, **U1**: Small nuclear RNAs that participate in pre-mRNA splicing and are important for ribonucleoprotein complex assembly.
- **RPL5** and **RPL11**: Ribosomal proteins that are part of the large subunit and play roles in the assembly and maturation of ribosomes.

#### 2. Aging and Age-related Diseases
While specific studies on DDX52 and aging are limited, its role in ribosome biogenesis and translational control may implicate it in aging processes, as ribosome biogenesis generally decreases with age. The reduced protein synthesis capacity in aging cells can lead to cellular senescence, which is a hallmark of age-related diseases. Aberrations in ribosome biogenesis or translation regulation have been associated with various forms of cancer, neurodegenerative diseases, and other age-related disorders. Further research may be necessary to elucidate the direct impact of DDX52 on aging and specific age-related pathologies.

#### 3. Drug Interaction
Currently, there are no specific drugs or drug classes that are widely recognized to interact directly with DDX52. However, as a part of ribosome biogenesis and related to translational processes, certain drugs that impact protein synthesis (antibiotics like puromycin or inhibitors of translation) may indirectly affect the function of DDX52 by interfering with the ribosome assembly process.

#### 4. Pathways and Biological Processes
DDX52 is involved in several critical pathways and biological processes, including:
- **Ribosome Biogenesis**: Responsible for the processing and assembly of ribosomal RNA components and ribosomal proteins.
- **RNA Processing**: Facilitates various RNA metabolic processes, including splicing and maturation.
- **Regulation of Gene Expression**: DDX52 may be involved in controlling the expression of mRNAs with specific features, such as those containing terminal oligo pyrimidine (TOP) motifs.
- **Cell Cycle Regulation**: Through its function in the translation of certain mRNAs, DDX52 may contribute to the regulation of the cell cycle, particularly in response to growth signals and cellular stress.

#### Conclusion
DDX52 is a multifunctional gene with vital roles in ribosome biogenesis and potential implications in cellular aging and processes related to age-associated diseases. Further investigation into its interactions, regulation, and impact on health may provide valuable insights into its broader biological significance.