### KIF14 Gene Overview

**Gene Symbol**: KIF14  
**Location**: Chromosome 1q42.13  
**Gene Description**: KIF14 encodes a member of the kinesin-3 superfamily of microtubule motor proteins, crucial for various cellular processes, including vesicle transport, chromosome segregation, and cytokinesis. 

### 1. Genes Associated with KIF14

In addition to the mentioned interactions with PRC1 and CIT during cytokinesis, KIF14 has been associated with several other genes, including:

- **CDKN1B (p27Kip1)**: KIF14 regulates the degradation of CDKN1B, which is involved in cell cycle control.
- **CCNE1, CCND1, CCNB1**: Cyclins that are regulated in the cell cycle progression influenced by KIF14.
- **RADIL**: A protein that interacts with KIF14, influencing cell spreading and migration.

These associations underline KIF14's role in various signaling pathways and cellular functions.

### 2. Aging and Age-Related Diseases

Research has suggested that KIF14 may be involved in processes related to aging and age-related diseases, particularly through its role in:

- **Cell Cycle Regulation**: Dysregulation of cell cycle progression can lead to age-related cellular dysfunction and contribute to the aging process, particularly through its interactions with tumor suppressor genes.
- **Cancers**: KIF14 has been identified as a likely oncogene in multiple cancers, including breast, lung, ovarian cancers, retinoblastomas, and gliomas. Cancer development is often associated with aging, as mutations accumulate over time.
- **Neurogenesis**: Its regulation of neural development and proliferation may play a role in cognitive decline associated with aging.

### 3. Drug Interactions

Currently, there is no specific list of drugs targeting KIF14 directly reported in the literature. However, the following drug classes may indirectly impact its function through pathways it is involved in:

- **Microtubule-targeting Agents**: Drugs like paclitaxel and vincristine, which impact microtubule dynamics, could effectively interfere with the functions of kinesin motor proteins, including KIF14.
- **Antineoplastic Agents**: Given KIF14's role in oncogenesis, compounds that target cancer pathways may also affect its activity indirectly, though specific interactions remain to be fully elucidated.

### 4. Pathways and Biological Processes

KIF14 is involved in several biological processes and signaling pathways:

**Biological Processes**:
- **Cytokinesis**: Essential for successful cell division, targeting to spindle midbody.
- **Microtubule Dynamics**: Involved in chromosome congression, alignment, and regulation of spindle formation.
- **Cell Proliferation**: Influencing development and tumorigenesis via cell cycle modulation.

**Pathways**:
- **Cell Cycle Regulation Pathways**: Through interactions that regulate cyclins and CDKN1B degradation.
- **Apoptotic Signaling Pathways**: Regulating cell survival and proliferation during neurogenesis.
- **Integrin Activation and Cell Migration Pathways**: Through interactions with RADIL, modulating focal adhesions and cell movement.

### Summary

KIF14 is a vital gene implicated in various cellular processes, particularly those governing cell division and proliferation. Its potential role in age-related diseases and cancer emphasizes its importance in ongoing research, particularly in therapeutic targeting and understanding its mechanisms in cellular and developmental biology.