### TEX10 Gene Overview

**Gene Symbol:** TEX10  
**Location:** Mitochondrion and nucleoplasm.

**Function:** TEX10 has been characterized as part of the MLL1 (Mixed lineage leukemia 1) complex and plays a crucial role in the Five Friends of Methylated CHTOP (5FMC) complex. It is involved in recruiting the 5FMC complex to ZNF148 (also known as ZNF148), leading to the desumoylation of ZNF148, which is essential for the transactivation of ZNF148 target genes. Additionally, TEX10 is part of the PELP1 complex, which is implicated in nucleolar processes related to 28S rRNA maturation and the transit of the pre-60S ribosomal subunit to the nucleoplasm.

### 1. Associated Genes

While the provided summaries mention the ZNF148 and PELP1 components, TEX10 may also be associated with other genes within regulatory and cellular processes. Some potential genes include:
- **MLL1 (KMT2A)** – As part of the MLL1 complex, TEX10 is connected with genes involved in histone methylation and transcription regulation.
- **CHTOP** – An important interacting protein that is substrates for methylation and is a part of the 5FMC.
- **rRNA processing genes**, as TEX10 is implicated in the maturation of rRNA.

### 2. Aging or Age-Related Diseases

There is not extensive literature directly linking TEX10 to aging or age-related diseases specifically. However, as a component of complex biological processes such as gene regulation and ribosome biogenesis, disruptor or dysregulation of TEX10 might indirectly influence cellular aging and associated pathways. Alterations in ribosomal function and transcriptional regulation are often correlated with age-related decline in cell function and may contribute to diseases like cancer and neurodegeneration, where dysregulation of gene expression features prominently. Further research could elucidate any direct roles TEX10 might have in these contexts.

### 3. Drug Interactions

Currently, there is limited direct information concerning specific drugs or drug classes that interact with the TEX10 gene or its protein product. However, potential interactions may be inferred based on its involvement in cellular processes:
- **Inhibitors of methylation** (e.g., a class of drugs targeting DNA methyltransferases), as TEX10 functions in the context of methylation via the 5FMC.
- **Compounds that affect ribosome biogenesis** could indirectly impact TEX10 activity due to its role in rRNA maturation.

As the research landscape evolves, more targeted studies may uncover specific drugs impacting TEX10-related pathways.

### 4. Pathways and Biological Processes

TEX10 is involved in:
- **Histone Methylation Regulation**: Being a part of the MLL1 complex, it participates directly in modifying chromatin structure and regulating gene expression through histone modification.
- **Ribosomal RNA Processing**: As part of the PELP1 complex, involved in steps essential for the proper maturation and function of ribosomal RNA, which is crucial for protein synthesis.
- **Gene Transactivation**: Through the 5FMC complex, TEX10 enhances transcriptional activation of genes regulated by ZNF148, indicating its role in broader gene regulation networks.

In summary, TEX10 is an important gene with implications in transcriptional regulation, rRNA processing, and possibly in age-related biological changes, although more studies are required to elucidate its full significance in these areas.