### DYNC2LI1 Gene Overview

**Gene Name:** DYNC2LI1  
**Gene Symbol:** DYNC2LI1  
**Chromosomal Location:** Human chromosome 14q24.1  

### Function and Role
The DYNC2LI1 gene encodes a protein that is an integral component of the dynein-2 microtubule motor protein complex. This protein is essential for retrograde transport of cargo in primary cilia through the intraflagellar transport (IFT) system. Its functions include:

1. **Microtubule Transport:** The dynein-2 complex, of which DYNC2LI1 is a part, facilitates the movement of various cargoes along microtubules, which is vital for maintaining ciliary function and integrity.
2. **Cilia Regulation:** DYNC2LI1 plays a role in regulating ciliary length and assembly, critical for physiological processes that involve sensory cilia.

### Associated Genes
While specific associated genes are not commonly highlighted in basic summaries, DYNC2LI1 is part of the larger dynein complex:

- **DYNC2H1** (Cytoplasmic dynein 2 heavy chain 1) - interacts directly with DYNC2LI1.
- **IFT complex genes** (such as IFT88, IFT20) - associated with intraflagellar transport mechanisms in cilia.

### Aging and Age-Related Diseases
Currently, there is no direct linkage between DYNC2LI1 and aging or age-related diseases described in literature. However, defects in ciliary function and the resultant ciliopathies can contribute to conditions that may manifest or worsen with age, such as:

1. **Ciliopathies:** Mutations in DYNC2LI1 are associated with several ciliopathies, including Short Rib Thoracic Dysplasia 15 with Polydactyly (SRTD15). While the direct correlation with aging is not established, ciliopathies may have complications that require consideration with age.

### Drug Interactions
As of now, no specific drugs or drug classes that directly interact with DYNC2LI1 have been documented. However, because the pathways involving this gene are connected to various cellular processes, it’s reasonable to assume potential indirect interactions may arise through therapies targeted at related dysfunctions.

### Pathways and Biological Processes
The DYNC2LI1 gene is involved in various biological processes and signaling pathways, including:

1. **Intraflagellar Transport (IFT):** Essential for ciliary function and structure.
2. **Cilia Assembly and Maintenance:** Plays a crucial role in the regulation of cilia structure.
3. **Motor Activity:** Integral to the functioning of motor protein complexes that aid in cargo transport along microtubules.
4. **Cellular Processes:** General cellular transport mechanisms, especially in neurodevelopment and organogenesis.

### Summary
The DYNC2LI1 gene encodes a pivotal component of the dynein-2 complex, facilitating ciliary transport essential for proper cellular function. While it has been linked to specific ciliopathies, further research is required to elucidate its broader implications in aging and pharmacological interactions. The gene's involvement in IFT and ciliary dynamics underscores its biological significance across various physiological processes.