### CREBBP Gene Overview

**Gene Symbol:** CREBBP  
**Gene Name:** CREB binding protein (CREBBP)  
**Location:** Chromosome 16p13.3  
**Function:** Transcriptional coactivation, histone acetylation, coupling chromatin remodeling to transcription.

### 1. Associated Genes
Besides those mentioned in the NCBI and UniProt summaries, CREBBP is associated with several other genes, including, but not limited to:

- **TP53:** CREBBP interacts with the TP53 tumor suppressor, influencing its transcriptional activity.
- **MYC:** The MYC oncogene, which is involved in cell proliferation, also interacts with CREBBP.
- **FOXO3:** A member of the Forkhead box protein family, which is involved in stress resistance and metabolism.
- **SMAD3:** A signaling protein in the TGF-beta pathway that interacts with CREBBP.
- **SP1:** A transcription factor that also associates with CREBBP for gene regulation.
  
### 2. Aging and Age-Related Diseases
CREBBP has been implicated in various processes related to aging and age-associated diseases:

- **Aging Process:** Since CREBBP is involved in chromatin remodeling and transcriptional regulation, its activity is thought to affect cellular senescence and lifespan.
- **Rubinstein-Taybi Syndrome:** This genetic disorder, caused by mutations in CREBBP, has implications for neurodevelopmental disorders and can influence longevity and quality of life.
- **Cancer:** Chromosomal translocations involving CREBBP are noted in acute myeloid leukemia (AML) and other cancers, where alterations in gene expression may lead to increased cell proliferation and reduced apoptosis.
- **Neurodegenerative Diseases:** The involvement of CREBBP in various signaling pathways suggests it may play a role in neurodegenerative diseases, characteristically associated with aging.

### 3. Drug Interactions
- **Histone Deacetylase Inhibitors (HDACi):** These drugs can inhibit the action of enzymes that remove acetyl groups; thus influencing the acetylation status mediated by CREBBP.
- **Acetylation Modulators:** Compounds that change acetylation patterns of histones or non-histone proteins could have indirect effects on CREBBP function.
- **Oncologic Therapeutics:** Given its role in cancer, drugs targeting signaling pathways disrupted by mutations in CREBBP may also interact or show effects through this gene.

### 4. Pathways and Biological Processes

CREBBP is involved in several critical biological pathways and processes:

- **Transcription Regulation:** CREBBP primarily functions as a transcriptional coactivator for various transcription factors, including CREB, c-Myc, and NF-kB, enhancing their transcriptional activity.
- **TGF-beta Signaling Pathway:** It acts as a coactivator of SMAD proteins in the TGF-beta signaling, influencing processes such as cell growth and differentiation.
- **Circadian Rhythm Regulation:** CREBBP plays a role in enhancing circadian rhythms through its interaction with NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers.
- **Cell Growth and Division:** Through regulating the expression of genes involved in cell cycle progression and apoptosis, CREBBP indirectly contributes to growth control.
- **DNA Repair Mechanisms:** Its role in the acetylation of proteins such as PCNA highlights its involvement in DNA damage repair processes.

### Concluding Remarks
As a multifaceted gene, CREBBP is critical for various transcription-dependent processes and has implications in development, cancer biology, and potentially aging. Understanding its interactions and regulatory mechanisms can provide insights into therapeutic strategies for associated disorders.