### KIF25 Gene Overview

**Gene Symbol:** KIF25  
**Function:** KIF25 encodes a kinesin-like protein that belongs to the motor protein family known for its role in microtubule-based transport and movement during cell division. While its exact function is still being elucidated, it has been implicated as a negative regulator of centrosome separation and is critical in maintaining nuclear centering during mitosis.

### 1. Associated Genes

Although specific associations of KIF25 with other genes were not elaborated in the summaries provided from NCBI and UniProt, kinesins often interact with other proteins involved in microtubule dynamics, cell division, and intracellular transport. Some genes typically associated with kinesin activity include:

- **KIF5B**, Kinesin Family Member 5B, known for its role in mitochondrial transport.
- **KIF1A**, Kinesin Family Member 1A, vital for neuronal transport.
- **KIF2A**, Kinesin Family Member 2A, linked to chromosome movement during cell division.

### 2. Aging and Age-Related Diseases

While direct studies linking KIF25 to aging or age-related diseases are sparse, there is general interest in the role of kinesins in cellular processes that impact aging. Impairments in mitotic spindle orientation and centrosome function can lead to aneuploidy and other cellular dysfunctions associated with aging. 

Moreover, as KIF25 may be involved in regulating autophagy upon amino acid starvation, any disruption in this function could potentially relate to age-related diseases, such as neurodegenerative disorders where autophagy plays a critical maintenance role. The potential involvement in centrosome dynamics suggests a role in conditions like cancer, where aging is a risk factor for tumorigenesis.

### 3. Drug Interactions

Currently, there is limited information specifically regarding drug interactions with KIF25. However, as a kinesin protein, it might interact indirectly with drugs that target microtubule dynamics, such as:

- **Taxanes** (e.g., Paclitaxel), which stabilize microtubules and are used in cancer therapy.
- **Vinca Alkaloids** (e.g., Vincristine), which disrupt microtubule polymerization.

Potential off-target effects may also arise with other agents impacting cellular transport and mitotic function.

### 4. Pathways and Biological Processes

KIF25 is involved in several critical cellular processes and pathways, including:

- **Microtubule cycling and dynamics:** Essential for intracellular transport and stabilization of the mitotic spindle.
- **Centrosome regulation:** Prevents premature centrosome separation during interphase, ensuring proper cell division.
- **Mitotic spindle orientation:** Ensuring the spindle apparatus is correctly aligned at mitosis onset, essential for proper chromosome segregation.
- **Autophagy regulation:** May play a role in response to cellular nutrient status, influencing cellular homeostasis and metabolism.

### Summary

KIF25 is a yet-to-be fully characterized kinesin-like protein with roles in microtubule dynamics, centrosome function, and possibly autophagy. Its associations with other kinesin proteins, the implications in aging and age-related diseases, potential drug interactions, and significant biological processes highlight its importance in cellular function and integrity. Further studies would be beneficial to explore the specific mechanisms by which KIF25 influences these pathways and its relevance to disease states.