### DRG1 Gene Summary

**Gene Symbol**: DRG1  
**Description**: DRG1 (Developmentally Regulated GTP Binding Protein 1) is involved in several cellular functions, notably GTPase activity, protein binding, and potassium ion binding. It plays a critical role in microtubule polymerization and mitotic spindle assembly, essential for proper cell division.

### Additional Information

1. **Associated Genes**:
   - **ZC3H15/DFRP1**: It is known to stimulate the GTPase activity of DRG1 and may facilitate its binding to potassium ions.
   - Other genes potentially associated with DRG1 through pathways involving microtubule dynamics and cellular regulations include genes involved in the wider mitosis and cytokinesis processes, such as **TPX2**, **BUB1**, and **KIF2C**. However, specific literature may help identify any direct interactions or associations beyond functional gene sets.

2. **Aging and Age-Related Diseases**:
   - While there are no direct studies linking DRG1 specifically to aging processes, its roles in microtubule dynamics and cell division suggest a potential involvement in age-related cellular phenomena, such as cellular senescence and the malignancy of age-related diseases. Altered microtubule function has been noted in neurodegenerative diseases like Alzheimer's disease, where proper mitotic spindle assembly and cellular integrity are crucial.
   - Studies show that proteins involved in GTPase activity often influence pathways related to aging and cancer, highlighting indirect connections between DRG1 and age-related pathological conditions.

3. **Drug Interactions**:
   - Currently, there are no specific FDA-approved drugs that target DRG1 directly. However, since DRG1 is implicated in cellular proliferation and microtubule dynamics, it may be affected by drugs that influence these pathways, such as:
     - **Taxanes** (e.g., Paclitaxel) - disrupt microtubule dynamics.
     - **Vinca alkaloids** (e.g., Vincristine) - affect microtubule assembly.
   - Future studies may reveal more specific interactions or implications for therapeutics targeting pathways involving DRG1.

4. **Pathways and Biological Processes**:
   - **Mitotic Spindle Assembly**: DRG1 is critical for assembling the mitotic spindle, impacting proper chromosome segregation during cell division.
   - **Microtubule Dynamics**: Enhances microtubule polymerization and stability, which is vital for various cellular processes.
   - **Regulation of Translation**: When hydroxylated, DRG1 may interact with RNA, suggesting a role in regulating protein synthesis.
   - **GTP Hydrolysis**: Facilitates processes requiring GTP binding and hydrolysis, which may contribute to various signal transduction pathways.

### Conclusion
The DRG1 gene is essential for cellular proliferation and microtubule activities, which may indirectly impact aging and diseases such as cancer. Further research into its interactions and potential drug targets could offer insights into therapeutic interventions for age-related and proliferative diseases.