### GSK3B Gene Overview

**Gene Symbol**: GSK3B  
**Location**: Chromosome 3 (3q13.3)  
**Gene Type**: Protein-coding gene  

#### Other Associated Genes:
1. **NFKB1**: GSK3B regulates NF-kappa-B, influencing its transcriptional activity.
2. **MCL1**: Phosphorylation of MCL1 by GSK3B regulates apoptosis.
3. **AMPK**: GSK3B potentially interacts with AMPK signaling pathways, which are crucial for energy homeostasis.
4. **PTEN**: GSK3B may influence pathways involving PTEN, which is a critical tumor suppressor.
5. **AKT**: Interplays with the Akt signaling pathway, affecting cellular glucose metabolism and survival pathways.

#### Aging and Age-Related Diseases:
- **Neurodegenerative Diseases**: GSK3B has been linked to Alzheimer’s disease and Parkinson’s disease, with its role in tau phosphorylation contributing to neurofibrillary tangles, a hallmark of Alzheimer's disease.
- **Diabetes**: The negative regulation of insulin signaling by GSK3B may contribute to insulin resistance, often exacerbated in aging populations.
- **Cancer**: Dysregulation of GSK3B activity has been implicated in cancer progression and metastasis. As aging can increase the risk of cancer, GSK3B's role in cell cycle regulation could have implications in age-related oncogenesis.

#### Drug Interactions:
- **Lithium**: A common treatment for bipolar disorder that inhibits GSK3B activity, affecting neuroprotective pathways that have potential applications in treating age-related neurodegenerative diseases.
- **Investigational Inhibitors**: Ongoing research into GSK3B inhibitors may lead to therapeutic options for Alzheimer’s disease or diabetes.
  
#### Pathways and Biological Processes:
- **Energy Metabolism**: GSK3B is critical in regulating glucose and lipid metabolism.
- **Wnt Signaling Pathway**: Negative regulation of beta-catenin is vital for proper cell signaling and development.
- **Apoptosis**: Regulating apoptotic pathways through phosphorylation of pro-apoptotic and anti-apoptotic proteins.
- **Cell Cycle Regulation**: Influences transition through the cell cycle via various interactions with the cell cycle machinery.
- **Inflammatory Responses**: Plays a role in the activation and regulation of inflammatory responses, which are central to many chronic diseases that become prevalent with age.
- **Circadian Rhythm**: Regulates the expression of key clock proteins, contributing to circadian rhythm maintenance.

### Summary
GSK3B is an integral serine-threonine kinase involved in multiple cellular processes essential for maintaining glucose homeostasis and regulating apoptosis, inflammatory responses, and the cell cycle. Its dysregulation has significant implications in aging and age-related diseases, particularly neurodegenerative disorders and metabolic syndrome. Understanding its interactions with various pathways and potential drug targeting is crucial for developing therapeutic strategies for related conditions.