### RNU6-658P Gene Overview

**Gene Symbol:** RNU6-658P

**Description:** RNU6-658P is a gene that is part of the non-coding RNA (ncRNA) category, specifically a member of the U6 small nuclear RNA (snRNA) family. The U6 snRNAs are primarily involved in the splicing of pre-mRNA in the nucleus through their role in forming the spliceosomal complex, crucial for the removal of introns and the joining of exons.

#### 1. Associated Genes

While specific associated genes for RNU6-658P are not typically highlighted in Eukaryotic databases like NCBI or UniProt, it is known that snRNAs and their processing components can interact with various other genes involved in the spliceosome machinery. Some key associated genes that may be involved in pre-mRNA splicing and associated pathways include:

- **SNRNP70**: Encodes a core component of the spliceosome.
- **SNRNP200**: Involved in the unwinding of RNA during splicing.
- **PRPF8**: Plays a crucial role in the spliceosome assembly and function.

#### 2. Aging and Age-related Diseases

Currently, there is limited direct information regarding RNU6-658P's association with aging or specific age-related diseases. However, as an ncRNA involved in the splicing process, alterations in snRNA processing have been implicated in various age-related conditions, particularly those involving gene expression and regulation. Changes in splicing patterns over time have been associated with:

- Neurodegenerative diseases (e.g., Alzheimer's disease)
- Cardiovascular diseases

Research into the broader impacts of small nuclear RNAs on cellular aging and disease processes continues to evolve, and future studies may clarify the age-related relevance of RNU6-658P specifically.

#### 3. Drug Interactions

As of October 2023, there are no specific drugs or drug classes that are documented to interact directly with the RNU6-658P gene. However, drugs that target the splicing process or modulate splicing machinery broadly may, as a secondary effect, influence the expression or function of snRNAs, including RNU6-658P.

#### 4. Pathways and Biological Processes

RNU6-658P is mainly involved in the following biological processes:

- **mRNA Splicing:** Acts as a core component in catalyzing the excision of introns from pre-mRNA.
- **Gene Expression Regulation:** By participating in mRNA processing, it indirectly regulates gene expression levels in the cell.

Particularly, as a part of the U6 snRNA family, it participates in the broader **spliceosome assembly** and function pathways critical for ensuring accurate and efficient splicing of pre-mRNA, crucial for normal cell function and maintaining cellular homeostasis.

### Summary

RNU6-658P is an important non-coding RNA that plays a crucial role in mRNA splicing and gene expression regulation. Its associations with aging and age-related diseases require further study to elucidate its functional implications fully. Currently, it does not have documented interactions with specific drugs, highlighting its niche role in fundamental cellular processes.