**TTC3 Gene Overview:**

- **Gene Symbol:** TTC3
- **Function:** TTC3 encodes an E3 ubiquitin-protein ligase which is involved in the ubiquitination processes, particularly forming K48-linked polyubiquitin chains. It plays a pivotal role in mediating the ubiquitin-proteasome pathway for targeted protein degradation, primarily of phosphorylated Akt proteins and SMURF2, influencing various cellular processes including signaling pathways, epithelial-mesenchymal transition, and differentiation.

### 1. Associated Genes:
While the summaries primarily reference phospho-Akt (AKT1, AKT2, AKT3) and SMURF2, other genes that may be related to TTC3 through pathways of ubiquitination or signaling include:

- **RHOA**: Involved in actin cytoskeleton organization.
- **CIT (Citron Rho-interacting kinase)**: Involved in cell division and actin organization.
- **ROCK (Rho-associated protein kinase)**: Key regulator of the cytoskeleton and involved in many cellular functions.
- **TGFB1 (Transforming Growth Factor Beta 1)**: Regulates various cellular functions related to cell growth and differentiation.

### 2. Aging and Age-Related Diseases:
While specific studies directly linking TTC3 to aging are limited, the gene's involvement in the regulation of signaling pathways associated with cell proliferation and differentiation suggests that it may play a role in the aging process or in age-related diseases, such as:

- **Cancer:** As TTC3 is associated with the regulation of Akt signaling (which is often dysregulated in cancers), it has implications in tumorigenesis.
- **Neurodegenerative diseases:** Its role in neuronal differentiation underscores its potential in neurodevelopment and neurodegenerative processes, possibly influencing conditions like Alzheimer’s disease.

Emerging research might provide more conclusive links to specific age-related diseases as the understanding of its regulatory mechanisms in aging progresses.

### 3. Known Drug Interactions:
Currently, no specific drugs or drug classes are widely recognized in public databases as interactants with TTC3. However, since it has roles in cellular signaling pathways, some drugs targeting pathways involving AKT (such as AKT inhibitors) might indirectly affect TTC3's activity:

- **AKT inhibitors** (e.g., MK-2206, GSK690693): Aimed at inhibiting the Akt signaling pathway, potentially affecting TTC3 activity and function indirectly.
- **Proteasome inhibitors** (e.g., Bortezomib): While not directly interacting with TTC3, their mechanism targets proteasome-mediated degradation pathways where TTC3 is active.

Further investigations might be necessary to specifically map drug interactions to TTC3.

### 4. Pathways and Biological Processes:
TTC3 is involved in several key biological processes, including:

- **Ubiquitin-mediated proteolysis:** Particularly its role as an E3 ligase connecting target proteins to ubiquitin for degradation.
- **Regulation of Akt signaling:** Coordinates the protein levels of Akt (AKT1, AKT2, and AKT3) post-activation.
- **Epithelial-mesenchymal transition (EMT):** Facilitates processes related to cellular differentiation during development and in response to TGFB1 signaling.
- **Neuronal differentiation:** Plays a role in neuronal development through actin cytoskeletal remodeling.
- **Cell proliferation regulation:** Acts as a negative regulator of cellular growth and division.

**Conclusion:**
Understanding the functional role of the TTC3 gene has significant implications for research in cellular signaling, cancer biology, and potential therapeutic interventions. Further studies may reveal more connections, especially concerning age-related diseases and therapeutic potentials in targeting related signaling pathways.