### SNORD115-25 Gene Overview

**Gene Symbol**: SNORD115-25

**Description**: 
SNORD115-25 is classified as a non-coding RNA gene, specifically a small nucleolar RNA (snoRNA). SnoRNAs are primarily involved in the chemical modification of other RNA molecules, particularly ribosomal RNA (rRNA). They guide the methylation and pseudouridylation of rRNA, influencing ribosome biogenesis and function. SNORD115-25 is a member of the SNORD115 family, which has been implicated in the regulation of alternative splicing and gene expression.

### 1. Associated Genes
While the summaries provided by NCBI and UniProt may not specify other direct associations, snoRNAs like SNORD115-25 often interact with various ribosomal proteins and contribute to the assembly of the ribosomal subunits. Additionally, there may be associations with genes involved in processes regulated by the RNA modifications performed by snoRNAs, such as:
- Other members of the SNORD115 family (e.g., SNORD115-1)
- Ribosomal protein genes (e.g., RPLs, RPSs) 
- Genes involved in RNA processing and splicing 

### 2. Aging and Age-Related Diseases
Research has suggested that snoRNAs such as SNORD115-25 may play a role in cellular homeostasis and function, which could impact aging and age-related diseases, although specific studies directly linking SNORD115-25 to aging are limited. Alterations in snoRNA levels have been observed in various conditions, including:
- Neurodegenerative diseases (e.g. Alzheimer’s disease)
- Certain cancers
- Metabolic disorders

These associations suggest that abnormal expression of snoRNAs might influence pathways related to aging, primarily through effects on ribosomal function and gene expression regulation.

### 3. Drug Interactions
As of the information available till October 2023, there are no specific drugs directly targeting SNORD115-25 or its function documented in public databases. However, it is essential to consider that drugs affecting ribosomal function or RNA metabolism might indirectly influence the activity of SNORD115-25, particularly:
- Anticancer agents targeting ribosome biogenesis
- Drugs that modulate mRNA splicing or translation efficiency (e.g., spliceosome inhibitors)

### 4. Pathways and Biological Processes
SNORD115-25 is involved in a variety of biological processes, including:
- **Ribosome biogenesis**: SNORD115-25 plays a crucial role in the process of generating functional ribosomes by guiding the modification of rRNAs.
- **Pseudouridylation reactions**: It contributes to the isomerization of specific uridine residues, enhancing the stability and functionality of rRNA.
- **Gene expression regulation**: It may be implicated in the regulation of gene expression through mechanisms such as alternative splicing and RNA-editing processes.
- **Cellular stress response**: Its involvement in RNA homeostasis could affect how cells respond to stress, particularly in aging contexts.

### Conclusion
The SNORD115-25 gene is an essential player in the snoRNA family, crucial for the modification processes in RNA that guide ribosome functionality and gene expression. While specific connections to age-related phenomena and drug interactions are still emerging fields, broader implications related to cellular health and aging continue to be an area of active research.