### PARP10 Gene Overview

**Gene Symbol**: PARP10  
**Location**: Chromosome 1  
**Allowable Synonyms**: PARP-like protein 10, poly(ADP-ribose) polymerase family member 10

### 1. Associated Genes
In addition to GSK3B, PARP10 is associated with several proteins and genes involved in various cellular processes. Some notable associated genes include:
- **PCNA** (Proliferating Cell Nuclear Antigen): Involved in DNA replication and repair processes.
- **XRCC1** (X-ray Repair Cross Complementing 1): Plays a critical role in the base excision repair pathway.
- **BRCA1** (Breast Cancer 1): Involved in the repair of DNA double-strand breaks, which links to PARP10's involvement in DNA repair mechanisms.
- **TP53** (Tumor Protein p53): Falls within pathways regulated by PARP10, particularly in response to DNA damage.

### 2. Aging and Age-Related Diseases
PARP10 has been implicated in various biological processes that can influence aging and age-related diseases. While specific studies directly correlating PARP10 with aging are limited, its roles in DNA damage response and repair suggest potential associations with:
- **Cancer**: Dysregulation of DNA repair mechanisms is a known risk factor for cancer, indicating that PARP10 may participate in tumorigenesis through its role in DNA repair.
- **Neurodegenerative diseases**: By regulating cellular stress responses, including those related to oxidative stress and DNA repair, PARP10 might contribute to age-associated cognitive decline or neurodegeneration, although direct evidence is still required.

### 3. Drug Interactions
Currently, specific drugs or drug classes directly targeting PARP10 have not been widely reported. However, because PARP10 is involved in DNA repair processes similar to other PARP family members, drugs targeting the broader PARP family, such as PARP inhibitors (like Olaparib or Niraparib) used in cancer therapy, may have overlapping pathways involving PARP10.

### 4. Pathways and Biological Processes
PARP10 is involved in several critical pathways and biological processes:
- **DNA Damage Response and Repair**: PARP10 plays an essential role in the cellular response to DNA damage, predominantly through its action in translesion DNA synthesis, which allows DNA replication machinery to bypass damaged DNA sites.
- **Cell Cycle Regulation**: By regulating GSK3B activity, PARP10 is involved in maintaining appropriate cell cycle progression, especially following DNA damage.
- **Transcriptional Regulation**: PARP10 is implicated in transcription regulation, potentially influencing gene expression in response to cellular stress.
- **Cellular Stress Responses**: Engages in responses to various forms of cellular stress, indicating a broad role in maintaining cellular homeostasis.

Overall, while the PARP10 gene may not be as extensively studied as other members of the PARP family, it plays a crucial role in various cellular processes that can impact cancer biology and potentially influence aging and age-related diseases through its involvement in DNA repair mechanisms.