### ENPEP Gene Overview

**Gene Symbol:** ENPEP  
**Function:** The ENPEP gene encodes the enzyme glutamyl aminopeptidase, which is a type II integral membrane protein with an extracellular zinc-binding domain. It plays a crucial role in regulating blood pressure by cleaving the N-terminal aspartate from angiotensin II. Additionally, ENPEP is implicated in blood vessel formation and has been associated with enhanced tumorigenesis in various tissues.

### 1. Associated Genes
Beyond ANPEP and DPP4, which were mentioned in the summaries, ENPEP has been studied in the context of several other genes, including but not limited to:

- **ACE (Angiotensin I Converting Enzyme):** Involved in the renin-angiotensin system which regulates blood pressure.
- **AGT (Angiotensinogen):** The precursor protein for the active angiotensin peptides.
- **CAV1 (Caveolin 1):** Involved in signal transduction pathways and may influence the functioning of ENPEP.

### 2. Aging and Age-related Diseases
- **Hypertension:** As ENPEP is involved in blood pressure regulation, alterations in its activity can contribute to hypertension, which is a significant risk factor for age-related diseases, including cardiovascular diseases, stroke, and renal failure.
- **Cognitive Decline:** Research indicates that the renin-angiotensin system, modulated by enzymes like ENPEP, could play a role in neurodegenerative disorders, with potential connections to cognitive decline and Alzheimer’s disease.
- **Cancer:** The involvement of ENPEP in tumorigenesis may have implications in aging, as the risk of cancer increases with age.

### 3. Drug Interactions
Known drugs or drug classes interacting with ENPEP include:

- **Angiotensin II Receptor Antagonists (ARBs):** Such as losartan, which may impact pathways regulated by angiotensin II.
- **ACE Inhibitors:** Such as enalapril or lisinopril, which indirectly influence the function of ENPEP by altering angiotensin II levels.
- **Zinc supplements:** Since ENPEP has an extracellular zinc-binding domain, alterations in zinc levels may affect its enzymatic activity.

### 4. Pathways and Biological Processes
ENPEP is involved in several pathways and biological processes, including:

- **Renin-angiotensin system:** Critical for the regulation of blood pressure and fluid balance.
- **Peptide metabolism:** Modulates various bioactive peptides through its aminopeptidase function.
- **Neurobiology:** May be implicated in central nervous system processes that involve blood pressure regulation and neuroprotection.
- **Pathways related to cancer:** Suggested involvement in angiogenesis and tumor growth processes.

Overall, ENPEP is a significant gene with broad implications in cardiovascular health, aging, and cancer biology, and its study continues to provide insight into potential therapeutic targets for age-related diseases and hypertension. Further research is still needed to fully elucidate all the pathways and biological processes associated with ENPEP and its interaction with other genes and compounds.