### TUBAL3 Gene Overview

**Gene Symbol:** TUBAL3  
**Function:** The TUBAL3 gene encodes a protein that is predicted to play a significant role in cytoskeletal organization, particularly influencing microtubule dynamics. It is believed to engage in GTP binding and is a structural constituent of cytoskeleton elements.

### Additional Associated Genes
The TUBAL3 gene can be associated with various other genes that are involved in microtubule dynamics and cytoskeleton organization. Some related genes include:
- **TUBA1A, TUBA1B, TUBB**: These are tubulin family genes that encode α- and β-tubulin, which are key components of microtubules.
- **TPX2**: Involved in microtubule spindle assembly and stability.
- **KIF family genes** (Kinesin and Dynein): These motor proteins transport cellular components along microtubules.

### Age-Related Information
While specific associations between TUBAL3 and aging or age-related diseases may not be extensively documented, altered microtubule dynamics and impaired cytoskeletal function have been implicated in various age-related conditions, including:
- **Neurodegenerative diseases**: Alterations in microtubule stability can contribute to diseases like Alzheimer's and Parkinson's.
- **Cancer**: Changes in mitotic spindle formation and function due to microtubule instability may age-related increasing cancer risk.
- **Cellular senescence**: Defects in mitotic processes can affect tissue regeneration, often exacerbated in aged tissues.

### Drug Interactions
TUBAL3's involvement with microtubule dynamics makes it relevant in the context of certain chemotherapeutic drugs:
- **Taxanes (e.g., Paclitaxel)**: These drugs stabilize microtubules and inhibit their depolymerization, often used in cancer treatment.
- **Vinca alkaloids (e.g., Vincristine, Vinblastine)**: Act by disrupting the assembly of microtubules.
- **Colchicine**: Inhibits microtubule polymerization and can affect cell division.

### Pathways and Biological Processes
TUBAL3 is involved in several critical cellular pathways and processes, including:
- **Microtubule Cytoskeleton Organization**: Vital for maintaining cell shape and intracellular transport.
- **Mitotic Cell Cycle**: Essential during cell division for chromosome segregation.
- **Cellular Response to Stress**: Microtubules play a role in maintaining cell integrity under stress.
- **Intracellular Transport**: Facilitates movement of organelles and vesicles along microtubules.

### Summary
The TUBAL3 gene encodes a crucial component of the microtubule cytoskeleton, playing a significant role in cellular structure, mitosis, and potentially influencing age-related health. It interacts with various drugs primarily used in cancer therapy, highlighting its importance in both normal cellular function and pathological conditions. Further research may reveal more about its specific roles in aging and disease.