### NBEA Gene Overview

**Gene Symbol**: NBEA (Neurabin-2/Neurobeachin)

#### 1. Associated Genes
While the summaries specify certain roles for the NBEA gene, it has been implicated in interactions with various partners in biological processes, including:
- **AKAPs**: The NBEA protein is related to A-kinase anchoring proteins and may have functional ties with various subunits of protein kinase A (PKA), such as AKAP5.
- **Other A-kinase Anchoring Proteins (AKAPs)**: These proteins facilitate the spatial organization of PKA signaling and interactions with proteins such as AKAP9 and AKAP1, which may also influence pathways involving synaptic plasticity and cognition.
- **Neuronal Marker Genes**: Genes related to neuronal function and structure, such as *MAPT* (Microtubule-associated protein tau) and *SNCA* (alpha-synuclein), may also be associated with NBEA, given its expression pattern in the brain.

#### 2. Aging and Age-Related Diseases
- **Neurodevelopmental Disorders**: NBEA mutations have been associated with autism spectrum disorders (ASD), indicating a role in synaptic development and neuronal function. Such dysregulation can also potentially affect cognitive aging processes.
- **Multiple Myeloma**: The gene's expression changes in patients with multiple myeloma suggest a potential link to age-related conditions that demonstrate dysregulated protein trafficking and cellular signaling.
- **Neurodegenerative Diseases**: Given its association with neuronal functions, NBEA may be implicated in neurodegenerative diseases, where aging plays a crucial role in the pathophysiology.

#### 3. Drug Interactions
While specific drugs targeting NBEA have yet to be identified, its association with PKA and its regulatory functions suggest that drugs influencing PKA signaling pathways could indirectly impact NBEA activity. For example:
- **PKA Inhibitors**: Such as H89 or PKI (PKA inhibitor) could affect downstream processes regulated by NBEA.
- **Anticancer drugs**: Given the gene's implication in multiple myeloma, treatments used for this condition might affect genes associated with pathways where NBEA is active.

#### 4. Pathways and Biological Processes
NBEA is involved in several important biological processes and pathways:
- **Protein Kinase A Signaling**: Primarily involved in targeting PKA to specific cellular locales, aiding in spatial signaling.
- **Synaptic Transmission**: Modulating neuronal signaling pathways, essential for synaptic function and plasticity.
- **Neuronal Development and Maintenance**: It plays a role in post-Golgi trafficking, ensuring proper distribution of proteins to cellular membranes in neurons.
- **Endosome-Mediated Transport**: Suggesting a role in intracellular transport processes particularly relevant in neurons.

Overall, NBEA is a critical gene for neuronal function and signaling, with implications for developmental disorders and potentially age-related conditions, although specific connections remain an area of ongoing research.