### CCDC28B Gene Overview

**Gene Symbol:** CCDC28B  
**Location:** The CCDC28B gene is located on chromosome 8q24.3.

#### 1. Related Genes

CCDC28B is associated with several other genes and proteins, particularly those related to cilia function and Bardet-Biedl syndrome (BBS). Some notable genes include:

- **BBS proteins (BBS1, BBS2, BBS4, etc.):** These are part of the BBSome complex involved in ciliary trafficking and function.
- **ARL6:** A small GTPase that is also implicated in Bardet-Biedl syndrome.
- **MAPKAP1 (also known as SIN1):** Interacts with CCDC28B concerning cilia length regulation.
- **AKT1:** A key protein in the mTOR signaling pathway that CCDC28B may enhance phosphorylation of.

#### 2. Association with Aging or Age-Related Diseases

While specific aging-related functions are not explicitly detailed in the available literature for CCDC28B, there are some relevant associations:

- **Ciliary Dysfunction and Aging:** Cilia play crucial roles in various cellular processes, including signal transduction pathways. Dysregulation of ciliary function is known to be associated with aging and several age-related diseases.
- **Ciliopathies:** Given the involvement of CCDC28B in ciliogenesis and its association with Bardet-Biedl syndrome, mutations or dysregulation might predispose individuals to metabolic syndrome, which has links to aging and age-related conditions.

#### 3. Drug Interactions

Currently, there are no specific drugs or drug classes directly cited to interact with the CCDC28B gene. However, given that the protein product participates in pathways influenced by mTOR signaling, drugs affecting the mTOR pathway, such as:

- **Rapamycin:** This drug inhibits mTOR and might have indirect implications in CCDC28B's function regarding cilia length and assembly.
- **Metformin:** Commonly used in metabolic disorders, its interaction with ciliary signaling and regulation via the mTOR pathway might indirectly connect to CCDC28B's functions.

#### 4. Pathways and Biological Processes

CCDC28B is involved in several critical biological processes and pathways, including:

- **Ciliogenesis:** CCDC28B regulates the assembly and function of cilia, particularly influencing ciliogenesis and ciliary length.
- **mTOR Signaling Pathway:** While not directly involved with mTOR complex 1 (mTORC1), it modulates mTORC2 assembly and function, playing a role in cell growth and metabolic regulation.
- **Ciliary Function and Signal Transduction:** Cilia are critical for transmitting signals, particularly Hedgehog and Wnt pathways, which are vital for development and cellular communication.
- **Bardet-Biedl Syndrome Pathway:** As contributions to complex BBS proteins indicate a role in cilia-related syndromic conditions.

### Conclusion

CCDC28B is a ciliated-related gene with significant involvement in cilium formation and maintenance, playing essential roles in cellular signaling pathways, including the mTOR pathway. Although more research is needed to fully elucidate its functions and implications in age-related diseases, its connections with ciliopathies and related proteins underline its potential importance in both health and disease.