### RPL35AP22 Gene Overview

**Gene Symbol:** RPL35AP22  
**Location:** Human chromosome 3

The RPL35AP22 gene encodes a member of the ribosomal protein family. Specifically, it represents a pseudogene of ribosomal protein L35, a component of the ribosome that is essential for protein synthesis. Although it is classified as a pseudogene, its regulatory functions and potential involvement in disease processes continue to be investigated.

### 1. Associated Genes

RPL35AP22's pseudogene status indicates that while it may have evolutionary sequences derived from RPL35, it does not code for a functional protein. However, it may still exhibit associations with functional genes in regulatory networks or chromosomal regions. Direct associations to other specific genes are not well characterized in current databases; however, it may be part of networks involving other ribosomal proteins due to its homology to RPL35. Additionally, other genes on chromosome 3 may show co-regulation or linkage but are not specifically highlighted in the current literature.

### 2. Aging and Age-related Diseases

While specific studies linking RPL35AP22 directly to aging or age-related diseases are limited, it is known that ribosomal proteins play crucial roles in cellular processes such as protein synthesis, which can decline with age. Impairment in these processes can contribute to age-related diseases, including various forms of cancer, neurodegeneration, and metabolic disorders. Research has indicated that dysregulation of ribosomal proteins can influence cellular senescence and the aging phenotype, suggesting a potential indirect role for RPL35AP22 in these mechanisms.

### 3. Known Drug Interactions

As of October 2023, there is limited information regarding direct drug interactions specifically targeting RPL35AP22 due to its pseudogene status. However, drugs that affect ribosome biogenesis or function may have an indirect effect on the pathways involving RPL35AP22. Drug classes such as antibiotics (e.g., aminoglycosides) that inhibit ribosomal function might also influence the overall protein synthesis machinery where RPL35AP22 is situated.

### 4. Pathways and Biological Processes

RPL35AP22 is likely involved in pathways related to:

- **Ribosome Biogenesis**: Even as a pseudogene, it may play a regulatory role in the interplay of ribosomal structure and function.
- **Cell Growth and Proliferation**: Ribosomal proteins are critical for the translation processes that support cellular growth.
- **Response to Stress**: Some studies on ribosomal proteins suggest involvement in stress response pathways, which could link to cellular aging dynamics.

Its involvement in these pathways emphasizes its potential regulatory indirect influence rather than a direct mechanistic action on cellular or developmental processes.

### Summary

RPL35AP22 remains an area of active investigation with respect to its role in gene regulation and potential implications in aging and disease. Further studies are needed to elucidate the functional roles and interactions of this gene, given its pseudogene nature and the evolving understanding of ribosomal protein dynamics within cellular systems.