### RHOBTB1 Gene Overview

**Gene Symbol:** RHOBTB1  
**Location:** Chromosome 14q32.2  
**Protein Family:** Small GTPase superfamily, specifically within the Rho family.  

#### Key Functional Features
- The RHOBTB1 protein consists of a GTPase domain, a proline-rich region, two BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region.
- It is involved in regulating signal transduction pathways mediated by small GTPases and plays a significant role in the organization of the actin cytoskeleton.

### 1. Associated Genes
The RHOBTB1 gene has been studied in relation to several other genes and pathways, including but not limited to:
- **RHOB**: Another member of the Rho family, often in signaling pathways. 
- **RHOA, RHOC**: Other Rho GTPases that are involved in cellular signaling and cytoskeletal organization.
- **BTB-Kelch proteins**: Given the presence of BTB domains, these associated proteins might participate in similar pathways.

### 2. Aging and Age-Related Diseases
Research has suggested a link between RHOBTB1 expression and aging as well as various age-related diseases:
- **Neurodegenerative Diseases:** Some studies have implicated RHOBTB1 in the regulation of pathways associated with neurodegeneration, potentially affecting processes like synaptic formation and stability.
- **Cancer:** Altered expression of RHOBTB1 has been observed in different cancers, indicating a potential role in tumorigenesis, possibly linked to the aging process.
- **Cardiovascular Diseases:** Changes in actin organization mediated by RHOBTB1 may also contribute to age-related heart conditions.

### 3. Drug Interactions
While no specific drugs are universally associated with RHOBTB1, the following classes may interact indirectly through pathways involving small GTPases:
- **Chemotherapeutic agents:** Given the association with cancer, understanding how these drugs might affect RHOBTB1-mediated pathways is an area of study.
- **Cytoskeletal inhibitors:** Drugs that modify actin dynamics could influence the pathways or processes that RHOBTB1 regulates.

### 4. Pathways and Biological Processes
RHOBTB1 is involved in numerous biological processes and signaling pathways, including:
- **Cell Migration and Adhesion:** Associated with the organization of the cytoskeleton leading to altered cellular movement and adhesion capabilities.
- **Signal Transduction:** Plays a key role in GTPase-mediated signaling pathways, affecting cellular responses to various stimuli.
- **Developmental Processes:** Involved in tissue development, as indicated by its expression in various fetal and adult tissues.

### Conclusion
The RHOBTB1 gene encodes a protein that contributes significantly to cellular signal transduction and cytoskeletal dynamics. Its involvement in various biological processes, potential connections to age-related diseases, and expression across multiple tissues highlight its relevance in both normal physiology and pathophysiology. Understanding RHOBTB1's interactions and functions will further elucidate its role in health, disease, and aging.