### CEP112 Gene Overview

**Gene Symbol**: CEP112  
**Location**: Chromosome 3  
**Function**: CEP112 encodes a coiled-coil domain-containing protein that is involved in cellular organization and division, particularly in centriolar function and cell cycle regulation.

#### 1. Associated Genes
While the summaries provided do not explicitly list associated genes, CEP112 is notably involved or interacts with the following:

- **Maf1**: Involved in the regulation of RNA polymerase III and thereby influences GABA_A receptor surface expression.
- **Centrosomal proteins (e.g., CEP63, CEP152)**: Since CEP112 is a component of the centrosome, it may interact functionally with other centrosomal components.
- **GABA_A receptor genes (various subunits like GABRA1, GABRA2, etc.)**: Given its role in regulating GABA_A receptor expression, there's an indirect association here.
- **Cdc42**: As a member of the cell division control pathway, CEP112 is contextually related to genes controlling the cell cycle and cytoskeletal dynamics.

#### 2. Aging and Age-Related Diseases
While specific studies directly linking CEP112 to aging or age-related diseases may be limited, several possible connections include:

- **Senescence**: As with many centrosomal proteins, alterations or dysfunction in CEP112 may influence cellular senescence, impacting tissue homeostasis.
- **Neurodegenerative Diseases**: Given its role in neurons and dendritic development, disruptions in CEP112 function could theoretically contribute to synaptic dysfunction associated with conditions like Alzheimer’s disease.
- **Cellular Stress Responses**: As the cell cycle is affected by aging, mutations or dysregulation in genes like CEP112 could be implicated in age-related cellular integrity loss.

#### 3. Drug Interactions
Currently, the specific details surrounding drugs or drug classes that directly interact with CEP112 are not well established. However, due to its functional connections with GABA_A receptors, the following may be relevant:

- **GABA_A Receptor Modulators**: Drugs such as benzodiazepines (e.g., diazepam, lorazepam), which act on GABA_A receptors could theoretically exhibit effects influenced by the expression levels of these receptors regulated by CEP112.
- **Cancer therapeutics**: Since CEP112 is involved in the cell cycle, certain chemotherapeutics that target cell division could exhibit indirect effects.

#### 4. Pathways and Biological Processes
CEP112 participates in several critical biological processes, including:

- **Cell Cycle Regulation**: As a centrosomal protein, it plays a role in ensuring proper mitotic spindle formation and function.
- **Neurodevelopment**: In neurons, CEP112 is involved in dendritic development and GABA_A receptor trafficking, affecting neurotransmission and synaptic plasticity.
- **Centrosome Organization**: Helps maintain the structural integrity and function of centrosomes, crucial for mitosis and cellular organization.
- **Stress Response**: Interacts with pathways involved in cellular responses to stress, given its involvement with Maf1 and RNA polymerase regulation.

In conclusion, the CEP112 gene plays a multifaceted role in cellular functions, particularly in the context of cell division, neurodevelopment, and potentially in aging and age-related pathologies. While research directly tying it to specific drugs or pathways is ongoing, its importance in maintaining cellular integrity is clear. Further studies will enhance understanding of its implications in health and disease.