The PTGES2-AS1 gene, also known as Prostaglandin E Synthase 2 - Antisense RNA 1, is a gene that encodes a long non-coding RNA that is predicted to have important regulatory functions. Here are the details based on your queries:

### 1. Associated Genes:
PTGES2-AS1 has been linked to several other genes; however, specifics can vary based on biological context and literature updates. Commonly associated genes include:
- **PTGES2 (Prostaglandin E Synthase 2)**: As an antisense RNA, it may play a role in regulating the expression of its counterpart.
- Genes involved in prostaglandin biosynthesis and signaling pathways could also be relevant, including those in the COX (cyclooxygenase) pathway.

### 2. Aging and Age-Related Diseases:
Research surrounding PTGES2-AS1 and its potential implications in aging or age-related diseases is limited, but there are certain aspects to consider:
- **Inflammation**: Since PTGES2 influences prostaglandin synthesis, which is linked to inflammatory responses, it may play a role in age-related inflammatory conditions (e.g., arthritis, atherosclerosis).
- **Cancer**: Some studies suggest a link between prostaglandins and cancer progression, and the expression level of related non-coding RNAs could have implications in tumor biology and metastasis during aging.

### 3. Drug Interactions:
While direct drug interactions specific to PTGES2-AS1 have not been clearly defined in available literature, related prostaglandin pathways are targeted by:
- **Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)**: These drugs generally inhibit cyclooxygenase enzymes and might indirectly affect PTGES2 expression.
- **Prostaglandin E Receptor Antagonists**: Drugs targeting the receptors of prostaglandins (e.g., EP receptors) could also impact the pathways regulated by PTGES2.

### 4. Pathways and Biological Processes:
PTGES2-AS1 is implicated in various biological processes, primarily through its role in regulating PTGES2 and overall prostaglandin synthesis. The key pathways may include:
- **Prostaglandin Biosynthesis**: Involved in the conversion of arachidonic acid to prostaglandins, which are critical mediators in inflammation, pain, and physiological homeostasis.
- **Cellular Response to Stress**: Prostaglandins are known to play roles in how cells respond to diverse stress stimuli, including oxidative stress.
- **Regulation of Gene Expression**: As a long non-coding RNA, PTGES2-AS1 may influence the transcriptional landscape of associated genes, possibly through chromatin remodeling or recruitment of transcription factors.

In summary, while PTGES2-AS1 primarily relates to the regulation of prostaglandin synthesis via its association with PTGES2, its precise roles in aging and disease, direct drug interactions, and specific pathways need further exploration for more comprehensive insights.