### RNF213 Gene Overview:

**Gene Symbol:** RNF213
**Chromosomal Location:** 17q25.3
**Protein Function:** Atypical E3 ubiquitin ligase involved in protein and lipid ubiquitination.

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### 1. Associated Genes
In addition to the genes mentioned in the summaries (ALK and MYC), RNF213 has associations with the following genes:

- **FLNA (Filamin A):** Involved in cytoskeletal organization and is regulated by RNF213 in the context of Wnt signaling.
- **NFATC2 (Nuclear Factor of Activated T-cells):** Regulated by RNF213 during non-canonical Wnt signaling and is involved in immune response.
- **RSPO3 (R-spondin 3):** Elicits Wnt signaling and is important for vascular development.
- **P62/SQSTM1:** Known to be involved in autophagy processes affected by RNF213-mediated ubiquitination pathways.

### 2. Aging and Age-Related Diseases
- **Moyamoya Disease:** RNF213 has been linked to Moyamoya disease, a progressive cerebrovascular disorder commonly associated with aging and vascular risks.
- **Neurodegenerative Diseases:** There is emerging evidence that mutations in RNF213 may play a role in cerebrovascular dysfunction and contribute to conditions such as Alzheimer’s disease.
- **Metabolic Disorders:** RNF213’s role in lipid metabolism and fat storage suggests its potential involvement in age-related metabolic syndromes such as obesity and type 2 diabetes, conditions that often exacerbate with age.

### 3. Drug and Drug Classes
Currently, there are no specific drugs directly targeting RNF213, but due to its involvement in various biological processes, it may interact indirectly with:

- **Immunomodulatory drugs:** Drugs that alter immunity may impact pathways involving RNF213, considering its role in autophagy and immune response.
- **Antibiotics:** Since RNF213 is involved in cell-autonomous immunity against bacterial infections, modulation of its activity may influence the efficacy of certain antibiotics against intracellular bacteria.

### 4. Pathways and Biological Processes
RNF213 is involved in various pathways and biological processes, including:

- **Ubiquitin-mediated proteolysis:** Regulation of protein stability and degradation through ubiquitin tagging.
- **Angiogenesis:** Plays a critical role in blood vessel development, influenced by the non-canonical Wnt signaling pathway.
- **Cell-autonomous immunity:** Ubiquitinates lipopolysaccharides (LPS), regulating antibacterial responses and influencing autophagy.
- **Lipid metabolism:** Involves regulation of lipid droplet formation and fat storage, impacting physiological functions related to metabolism.

### Summary
The RNF213 gene plays significant roles in both basic cellular functions and specific diseases, particularly in the vascular system and during inflammatory responses. Its involvement in aging and metabolism highlights its potential as a target for understanding age-related diseases and developing therapeutic interventions. Further research is necessary to explore the interactions with drugs and detailed mechanisms of associated pathways.