### RNF152 Gene Overview

**Gene Symbol**: RNF152  
**Function**: RNF152 encodes an E3 ubiquitin-protein ligase that plays crucial roles in regulating protein stability and signaling pathways through ubiquitination, specifically targeting small GTPases and participating in the cellular response to nutritional status.

### 1. Associated Genes
While the summaries provided mention the involvement of RNF152 with the target protein RRAGA, other genes that may be associated, particularly in the context of the mTOR signaling pathway, include:
- **RAG proteins (RRAGA, RRAGB, RRAGC, RRAGD)**: These are part of the GTPase family involved in amino acid sensing.
- **MTOR**: The mechanistic target of rapamycin, which is key in cellular growth and metabolism.
- **ULK1**: Involved in autophagy regulation, which can interact with mTOR signaling.
- **ATG genes**: Related to autophagy and cellular stress responses.

### 2. Aging and Age-Related Diseases
Although specific studies directly linking RNF152 to aging processes are limited, its role in regulating TORC1 signaling is significant, as the mTOR pathway is implicated in aging and age-related diseases, including:
- **Age-related muscle wasting (sarcopenia)**: mTOR signaling is essential for muscle regeneration and maintenance.
- **Neurodegenerative diseases**: Dysregulation of protein homeostasis due to impaired ubiquitination can contribute to conditions like Alzheimer's and Parkinson's disease.

### 3. Drug Interactions
While comprehensive interaction data for specific drugs might not be extensively documented, pathways involving RNF152 may respond to:
- **mTOR inhibitors (e.g., Rapamycin)**: These could mediate effects linked to RNF152's regulatory role in TORC1 signaling under nutrient deprivation.
- **Proteasome inhibitors (e.g., Bortezomib)**: By altering protein degradation pathways, these drugs might influence the activity of ubiquitination mediated by RNF152.

### 4. Pathways and Biological Processes
RNF152 is involved in multiple key biological pathways and processes, including but not limited to:
- **Amino Acid Starvation Response**: RNF152 mediates cellular adaptation to limited nutrient availability.
- **Regulation of mTORC1 Signaling**: RNF152's action on RRAGA is critical for modulating mTOR activity based on nutritional cues.
- **Protein Polyubiquitination**: It plays a role in both Lys-48-linked and Lys-63-linked polyubiquitination, influencing protein degradation via the proteasome and various cellular responses.
- **Apoptosis Induction**: When overexpressed, it can lead to programmed cell death, highlighting its role in cellular stress responses.

### Conclusion
The RNF152 gene encodes a critical E3 ligase with significant functions in cellular nutrient sensing and signaling. Its role in various biological processes, including apoptosis and protein homeostasis, ties it to pathways that have implications in aging and age-related diseases. Further research could elucidate additional roles and interactions that enhance our understanding of RNF152’s implications in health and disease.