### KIFC3 Gene Overview

**Gene Symbol**: KIFC3  
**Gene Function**: The KIFC3 gene encodes a member of the kinesin-14 family of microtubule motor proteins, which are crucial for the dynamics of the mitotic spindle during cell division. Specifically, KIFC3 functions as a minus-end motor, facilitating the transport of cellular components along the microtubules and playing a role in the organization and maintenance of the cytoskeleton. It is involved in the final stages of cytokinesis and has been suggested to have additional roles in interphase cells related to cellular trafficking.

### 1. Associated Genes
KIFC3 may show associations with other genes involved in cell cycle regulation, spindle assembly, and cytokinesis, although specific gene interactions or associations are not clearly documented in the summaries provided. Some additional genes related to kinesin function or those involved in cytokinesis include:

- **KIF2A / KIF2B** (Kinesin-13 family): Involved in microtubule dynamics.
- **MKLP1** (Mitotic Kinesin-Like Protein 1): Plays a role in cytokinesis.
- **KIF4A**: Another kinesin that contributes to chromosomal segregation.
- **AURKA / AURKB** (Aurora Kinases): Involved in mitosis and cytokinesis.

### 2. Aging and Age-Related Diseases
Currently, direct associations between KIFC3 and aging or specific age-related diseases are less studied. However, since kinesins, including KIFC3, are essential during cell division and maintaining cellular function, any dysregulation in their activity could potentially contribute to age-related conditions such as:

- **Cancer**: As misregulation of spindle dynamics could lead to chromosomal instability, which is a hallmark of many cancers.
- **Neurodegenerative Diseases**: Impairments in transport mechanisms by motor proteins, including kinesins, may impact neuronal health and function over time.

Research focused on the role of KIFC3 in these contexts is still emerging, and further exploration is necessary to establish any clear links.

### 3. Drug Interactions
As of October 2023, there are no specific drugs directly targeting KIFC3 documented in major databases. However, drugs that affect microtubule dynamics, often used in cancer treatment, can indirectly influence the function of kinesin motors:

- **Taxanes (e.g., Paclitaxel)**: Stabilize microtubules and affect mitotic spindle function.
- **Vinca Alkaloids (e.g., Vincristine)**: Inhibit microtubule polymerization.
- **Colchicine**: Disrupts microtubules, which may impact kinesin motor activities.

### 4. Pathways and Biological Processes
KIFC3 is involved in several key biological processes, including:

- **Cytokinesis**: Key role in the final stages of cell division, ensuring proper cleavage of the cytoplasm.
- **Spindle Assembly**: Contributes to the formation and maintenance of the mitotic spindle during cell division.
- **Microtubule-Based Movement**: Functions in the transport of vesicles and organelles within cells.
- **Cell Adhesion**: Has been implicated in maintaining zonula adherens, a type of cell junction crucial for epithelial cell integrity.

The pathways that KIFC3 may be associated with include:

- **Cell Cycle**: Especially involving the transition through mitosis.
- **Signaling Pathways that Regulate Cell Growth and Division**: Potentially through interactions with signaling molecules or structures involved in cell adhesion and the cytoskeletal organization.

### Conclusion
KIFC3 plays critical roles in cell division and intracellular transport. While specific links to aging or drug interactions are limited, its function in maintaining spindle dynamics and cellular organization implies potential relevance in cancer and other conditions related to cell division dysregulation. Further investigations may clarify its roles in aging and the therapeutic implications in age-related diseases.