### NCOA7-AS1 Gene Summary

**Gene Symbol**: NCOA7-AS1  
**Description**: NCOA7-AS1 (Nuclear Receptor Coactivator 7 Antisense RNA 1) is a long non-coding RNA (lncRNA) that is involved in regulating gene expression. LncRNAs like NCOA7-AS1 play vital roles in chromatin remodeling, transcriptional regulation, and modulation of various cellular pathways.

### 1. Associated Genes
While specific genes directly associated with NCOA7-AS1 may not be comprehensively documented in only NCBI or UniProt summaries, lncRNAs often interact with or regulate various protein-coding genes, dependent on their function and context in specific biological processes. Potential associated genes based on functional studies may include:

- **NCOA7**: The protein-coding gene for which NCOA7-AS1 serves as an antisense RNA. It is involved in regulating transcription by nuclear hormone receptors.
  
Other genes potentially associated through regulatory networks or co-expressed patterns might include:
- **Nuclear receptor family genes**: A general class that includes various members which NCOA7 may regulate.
- **Cell cycle regulators**: As many lncRNAs are involved in cell proliferation.
  
Specific associations may be highly context-dependent or vary based on particular tissues or experimental conditions.

### 2. Aging and Age-related Diseases
Current research suggests that many lncRNAs, including NCOA7-AS1, could play roles in aging and age-related diseases, predominantly through their regulatory effects on gene expression involved in metabolic processes, inflammation, and cellular senescence. 

While direct studies linking NCOA7-AS1 to specific aging mechanisms or pathological conditions may be limited, its association with NCOA7 highlights its possible involvement in metabolic regulation and potentially in age-related metabolic disorders, such as obesity or diabetes. 

### 3. Drug Interactions
Currently, specific drugs or drug classes that interact with NCOA7-AS1 are not well-characterized. However, knowing that NCOA7-AS1 interacts with nuclear receptors implies potential relevance to:
- **Hormonal therapies**: Drugs that target nuclear hormone receptors, including corticosteroids and sex hormones.
- **Anticancer agents**: As nuclear receptor signaling can influence tumorigenesis, agents targeting these pathways may indirectly modulate NCOA7-AS1 expression.

There may be ongoing research examining NCOA7 or its interactions in the context of drugs used for metabolic or age-related diseases that require further exploration.

### 4. Pathways and Biological Processes
NCOA7-AS1 is involved in several biological processes, including:
- **Regulation of transcription**: Particularly in responses to nuclear hormone signaling.
- **Chromatin remodeling**: Impacting gene accessibility and expression.
- **Cellular growth and proliferation**: Through interactions with various signaling pathways relevant to metabolism and functionality.

Specific pathways that NCOA7-AS1 may impact include:
- **Nuclear receptor signaling pathways**: Since it is an antisense RNA of a nuclear coactivator, it likely has a role in pathways driven by steroid hormones, thyroid hormones, and retinoic acid.
- **Cell cycle regulation**: Given the lncRNA's potential influence on cellular proliferation.

### Conclusion
Overall, NCOA7-AS1 is emerging as a significant player in gene regulation with potential implications for aging and disease, although more research is necessary to clarify its roles and interactions fully. Continued exploration in this area could illuminate its significance in therapeutic contexts and its exact mechanisms within cellular biology.