### DCLRE1A Gene Overview

**Gene Symbol:** DCLRE1A  
**Chromosomal Location:** Human chromosome 10

#### General Function
The DCLRE1A gene encodes a protein that plays a critical role in the repair of DNA interstrand cross-links, which can impede crucial cellular processes such as transcription and replication. In addition to its function in DNA repair, it is also involved in the regulation of the mitotic cell cycle checkpoint. This ensures the cell does not divide improperly in the presence of DNA damage. The protein exhibits beta-lactamase activity, hydrolyzing compounds such as penicillin G, but shows no activity toward certain other beta-lactam antibiotics.

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### 1. Associated Genes
DCLRE1A is associated with several other genes, particularly in the context of DNA damage response and repair mechanisms. While the specific names of these genes may not have been mentioned in the summaries you provided, commonly associated genes in the same pathways include:
- **BRCA1/BRCA2:** Tumor suppressor genes involved in DNA repair.
- **RAD51:** Key protein in homologous recombination and DNA repair.
- **ATM:** Involved in the detection of DNA damage and activation of the DNA repair pathway.

### 2. Aging and Age-Related Diseases
Although specific studies directly linking DCLRE1A to aging or age-related diseases are limited, the involvement of DNA repair mechanisms in aging is well-established. Deficiencies in DNA repair, including interstrand cross-link repair, can lead to genomic instability, which is a hallmark of aging and contributes to age-related diseases, including cancer and neurodegenerative disorders. The functionality of DCLRE1A may thus have implications for longevity and age-related health.

### 3. Drug Interactions
Drugs or drug classes known to interact with DCLRE1A primarily relate to its role in DNA damage response and repair:
- **Antineoplastic agents:** Drugs that induce DNA damage (e.g., cisplatin, doxorubicin) may interact with the pathways involving DCLRE1A as the protein plays a role in DNA repair.
- **Beta-lactam antibiotics:** While DCLRE1A has beta-lactamase activity specifically towards penicillin G, resistance mechanisms can influence treatment outcomes involving various beta-lactam drugs.

### 4. Pathways and Biological Processes
DCLRE1A is involved in several crucial biological processes and pathways:
- **DNA Damage Repair:** Specifically, it is involved in the repair of DNA interstrand cross-links, contributing to maintaining genomic stability.
- **Cell Cycle Regulation:** It plays a role in the mitotic checkpoint response to DNA damage, facilitating cell cycle arrest in the presence of mitotic spindle poisons.
- **Apoptosis and Cell Death:** Involvement in DNA repair pathways can influence apoptotic pathways when damage is irreparable.
- **Response to DNA Damage Stimuli:** DCLRE1A contributes to cellular responses to both intrinsic and extrinsic DNA damage signals.

### Conclusion
The DCLRE1A gene holds substantial importance in DNA repair mechanisms and cell cycle regulation, with implications for cancer biology and potentially age-related diseases. Its interactions with a variety of genes and pathways highlight its role as a pivotal component in maintaining genomic integrity. Further research may elucidate additional functional roles and therapeutic opportunities related to this gene.