### CDK14 Gene Overview

**Gene Symbol:** CDK14  
**Description:** The CDK14 gene encodes a serine/threonine protein kinase that is involved in regulating the eukaryotic cell cycle, particularly during the G2/M transition. CDK14 exhibits cyclin-dependent activity, and its kinase activity is modulated by its associating cyclins. The protein plays a significant role in the canonical Wnt signaling pathway and is known to phosphorylate LRP6 at 'Ser-1490', facilitating Wnt pathway activation.

### 1. Associated Genes
Although not exhaustive, the following genes may also be associated with CDK14 based on various biological functions and regulatory networks:

- **CCDN3 (Cyclin D3):** A cyclin that interacts with CDK14 to regulate cell cycle progression.
- **RB1 (Retinoblastoma 1):** A tumor suppressor gene that CDK14 may phosphorylate.
- **LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6):** A component of the Wnt signaling pathway affected by CDK14 activity.

### 2. Aging and Age-Related Diseases
While specific studies directly linking CDK14 to aging or age-related diseases may be limited, here are general associations:

- **Cell Cycle Regulation:** Dysregulation of cell cycle proteins, including CDK14, can lead to increased cellular senescence, which is a hallmark of aging.
- **Cancer:** Given its role in regulating the cell cycle and the Wnt pathway, aberrant function of CDK14 has been investigated in various cancers. Tumorigenesis is often associated with age, making CDK14 a potential contributor to age-related cancer development.
- **Neurodegenerative Diseases:** Considering its role in neuron differentiation, dysregulation of CDK14 may also have implications in neurodegenerative disorders, which are more prevalent in elderly populations.

### 3. Drug Interactions
While direct interactions of drugs with CDK14 may not be extensively characterized, the following types of drugs could theoretically influence its activity due to their roles in kinase inhibition or modulation within the cell cycle context:

- **CDK Inhibitors:** Given its kinase activity, CDK14 may be inhibited by drugs targeting CDKs, such as flavopiridol or AT7519. The detailed, specific interactions may need further investigation.
- **Wnt Signaling Modulators:** Drugs that impact the Wnt signaling pathway may indirectly affect CDK14 activity, particularly within cancer therapies.

### 4. Pathways and Biological Processes
CDK14 is involved in several key biological processes and signaling pathways, including:

- **Cell Cycle Regulation:** Primarily influences the G2/M transition during mitosis.
- **Wnt Signaling Pathway:** Mediates phosphorylation events that activate components of this pathway.
- **Meiotic Cell Cycle Regulation:** Possibly plays a role in meiosis, particularly in the context of germ cell development.
- **Cell Proliferation:** Works alongside other cyclins and regulators to influence cellular proliferation rates.
- **Neuron Differentiation:** May be implicated in the differentiation pathways of neuronal cells.

In summary, CDK14 serves as a crucial regulator in several key pathways related to the cell cycle and Wnt signaling, with potential implications for aging and age-related diseases, as well as interactively modulating drug responses in therapeutic contexts. Further research is required to elucidate the full spectrum of its roles.