The CPS1-IT1 gene, also known as CPS1 intronic transcript 1, is a long non-coding RNA located within an intron of the CPS1 gene, which encodes carbamoyl-phosphate synthetase 1, an enzyme critical for the urea cycle.

### 1. Associated Genes
While the primary association is with the CPS1 gene, there may be indirect associations with other genes involved in metabolic pathways related to urea metabolism or disorders. A few potential genes to consider include:
- **OTC (Ornithine Transcarbamylase)**: Another gene involved in the urea cycle.
- **ASL (Argininosuccinate Lyase)**: Also involved in urea cycle metabolism.
- **ARG1 (Arginase 1)**: Plays a role in the final step of the urea cycle.

Additionally, other non-coding RNAs may have regulatory relationships with CPS1-IT1.

### 2. Aging and Age-Related Diseases
CPS1-IT1, as a long non-coding RNA, may play regulatory roles in gene expression and be involved in processes tied to metabolism and disease. Research indicates that altered levels of non-coding RNAs can impact aging and age-related diseases.

While specific studies directly linking CPS1-IT1 to aging-related conditions are limited, the urea cycle's regulation is critical in metabolic health. Impairments in urea cycle can lead to conditions such as:
- Hyperammonemia
- Hepatic encephalopathy

Alterations in ammonia detoxification processes have been associated with aging-related cognitive decline and neurological issues.

### 3. Drug Interactions
While no specific drugs target the CPS1-IT1 gene directly, there may be associations with drugs that influence the urea cycle. Some classes of drugs that impact metabolic processes relevant to urea cycle disorders include:
- **Nitrogen scavengers**: Such as sodium benzoate and phenylbutyrate, which are used to help reduce ammonia levels in metabolic disorders.
- **Hepatic supplements**: Such as L-arginine or L-citrulline, which might be beneficial for managing symptoms of urea cycle disorders.

### 4. Pathways and Biological Processes
CPS1-IT1 is involved primarily in regulatory pathways rather than traditional metabolic pathways since it does not encode a protein. However, it does interact with processes tied to:
- **Urea Cycle Regulation**: By being placed within the CPS1 intron, it may influence the expression of the CPS1 gene itself.
- **Cellular Response to Metabolic Stress**: Non-coding RNAs including CPS1-IT1 can play roles in cellular responses to altered metabolic states.
- **Gene Expression Regulation**: As a long non-coding RNA, it may interact with transcription factors or other RNA molecules to modulate gene expression.

Further studies are needed to clarify specific roles of CPS1-IT1 within these pathways and identify any direct associations with aging or response to therapeutic interventions in related metabolic disorders.