### IL23R Gene Overview

**Gene Symbol**: IL23R  
**Location**: Chromosome 1 (1q32.2)  
**Gene Family**: Cytokine receptor family

The IL23R gene encodes a subunit of the interleukin-23 receptor, which is critical for the immune response. The interleukin-23 signaling pathway plays a significant role in the pathogenesis of several inflammatory and autoimmune diseases, as well as in certain cancers.

### 1. Associated Genes
While the NCBI and UniProt summaries mention IL12RB1, other genes that are associated with IL23R include:

- **JAK2**: Janus kinase 2, which interacts with IL23R for downstream signaling.
- **STAT3**: Signal transducer and activator of transcription 3, which is recruited in a ligand-dependent manner.
- **IL12A and IL12B**: Both are involved in IL-12 signaling and may indirectly relate to the function and regulation of IL-23 signaling.
- **TNF**: Tumor necrosis factor, as IL-23 can influence TNF production.

### 2. Aging and Age-Related Diseases
Research indicates possible links between the IL23R gene and age-related inflammation, which could contribute to conditions like:

- **Aging**: The IL-23 signaling pathway has been implicated in age-related systemic inflammation, contributing to the phenomenon known as "inflammaging."
- **Autoimmune Diseases**: Diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease (IBD), which can have increased prevalence with age and may be exacerbated by IL-23 signaling.
- **Cancer**: Certain age-related cancers could be influenced by the IL-23 mediated pathways as chronic inflammation can promote tumorigenesis.

### 3. Known Drug Interactions
Clinical applications targeting IL23R include:

- **Monoclonal Antibodies**: 
  - **Ustekinumab (Stelara)**: Targets IL-12 and IL-23, widely used in the treatment of psoriasis and Crohn's disease.
  - **Guselkumab (Tremfya)**: Specifically targets IL-23.
  - **Tildrakizumab (Ilumya)**: Another IL-23 inhibitor used for psoriasis.

- **Drug Classes**:
  - **Biologics** used for autoimmune diseases often target the IL-23/IL-17 axis (e.g., IL-23 inhibitors) that include monoclonal antibody therapeutics.

### 4. Pathways and Biological Processes
The IL23R gene is involved in a variety of biological pathways and processes, including:

- **Jak-Stat Signaling Pathway**: Activation of JAK2 leads to phosphorylation and activation of STAT3, which translocates to the nucleus to regulate gene expression.
- **Cytokine Signaling**: Plays a role in the interleukin-23 signaling pathway that is essential for T-cell differentiation, particularly Th17 cells.
- **Adaptive and Innate Immunity**: Modulates the immune response involving T-helper cells, natural killer (NK) cells, and possibly macrophages.
- **Inflammatory Response**: Associated with the response to infections and influencing the development of inflammatory diseases.

### Summary
The IL23R gene is a crucial component of the immune system, particularly in inflammatory and autoimmune responses. Its interactions with other genes and pathways highlight its importance in not only normal immune functions but also in the pathology of several age-related diseases and cancer. Targeting IL23R through specific drug interventions represents a significant advancement in treating related health conditions.