### ADGRL4 Gene Summary

**Gene Symbol:** ADGRL4  
**Description:** The ADGRL4 gene encodes a member of the adhesion G protein-coupled receptor (GPCR) family, specifically referred to as the endothelial orphan receptor. It plays a vital role in several physiological and pathological processes, notably angiogenesis, which is the formation of new blood vessels from pre-existing ones. This gene is implicated in the G protein-coupled receptor signaling pathways, leading to the activation of adenylate cyclase.

### 1. Other Associated Genes
ADGRL4 has been associated with several other genes that are involved in angiogenesis, cell signaling, and other cellular processes. Some of these may include:
- **VEGFA**: Vascular Endothelial Growth Factor A, involved in angiogenesis.
- **FZD4**: Frizzled class receptor 4, associated with Wnt signaling.
- **TEK (TIE2)**: A receptor tyrosine kinase that mediates endothelial cell survival and angiogenesis.
- **KDR (VEGFR2)**: The primary receptor for VEGFA, important for vascular development.

### 2. Aging and Age-Related Diseases
While specific studies on ADGRL4 directly related to aging are limited, it has been implicated in conditions like glioblastoma—an age-related cancer—and hypertrophic cardiomyopathy, which can affect older individuals. Impaired angiogenesis, a process regulated by ADGRL4, is known to correlate with aging and can lead to reduced tissue regeneration and increased incidences of age-related diseases, such as cardiovascular diseases.

### 3. Drug Interactions
Currently, there are no specific drugs known to interact directly with the ADGRL4 gene product. However, there are general classes of drugs that could potentially modulate GPCR pathways, such as:
- **Angiogenesis inhibitors**: Drugs that block pathways involved in angiogenesis (e.g., Bevacizumab, a monoclonal antibody targeting VEGFA).
- **G protein-coupled receptor antagonists**: These could influence GPCR signaling and might have downstream effects on ADGRL4 activity.

### 4. Pathways and Biological Processes
ADGRL4 is involved in several critical biological pathways, including:
- **G protein-coupled receptor signaling pathway**: Plays a role in the mediation of intracellular signaling and various physiological responses.
- **Adenylate cyclase-activating GPCR signaling pathway**: Involves the stimulation of adenylate cyclase, leading to increased levels of cAMP, a secondary messenger in signaling.
- **Angiogenesis**: Critical for blood vessel formation, with implications in various conditions, including cancer and cardiovascular diseases.
- **Regulation of endothelial cell function**: Influences processes such as permeability, migration, and proliferation of endothelial cells.

Overall, ADGRL4 is a significant gene that integrates various cellular processes and has potential implications in both normal physiology and pathological conditions, especially concerning angiogenesis and cancer biology. Further research could elucidate its precise roles in aging and age-related diseases.