### RUVBL1 Gene Overview

**Gene Symbol:** RUVBL1  
**Location:** Chromosome 17q25.3

**Description:**  
RUVBL1 encodes a protein with DNA-dependent ATPase and helicase activities, belonging to the AAA+ protein family. The protein plays crucial roles in transcription regulation, DNA repair, chromatin remodeling, and various cellular processes by interacting with several multiprotein complexes.

### 1. Associated Genes
RUVBL1 interacts with various genes/proteins, including but not limited to:
- **RUVBL2:** It forms a hetero-hexamer with RUVBL2 which is important in chromatin remodeling and transcription regulation.
- **EP400:** A component of the NuA4 complex that interacts with RUVBL1/2 for ATPase and helicase activities.
- **MYC:** It is implicated in transcriptional activation promoted by the oncogene MYC.
- **CTNNB1 (β-catenin):** Important in Wnt signaling; RUVBL1 modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
- **HIST1H4A** and **HIST2H2AA:** Associated with histone acetylation and chromatin remodeling processes.

### 2. Aging and Age-related Diseases
RUVBL1 has been implicated in various aspects associated with aging and age-related diseases, such as:
- **Cancer:** RUVBL1 is associated with oncogenesis and is overexpressed in several cancers (e.g., breast cancer, lung cancer), contributing to tumor proliferation and survival. Its roles in the regulation of transcription programs by oncogenes and tumor suppressors may link it to age-related tumorigenesis.
- **Replicative Senescence:** Research suggests RUVBL1 might impact cellular senescence, a critical aging process.
- **Alzheimer's Disease:** Elevated levels of RUVBL1 have been suggested in neurodegenerative conditions, including Alzheimer’s Disease, linking it to neuroinflammatory processes.

### 3. Drug Interactions
Currently, there are no specific drug classes universally recognized to directly interact with RUVBL1. However, it has been studied in the context of:
- **Histone Deacetylase Inhibitors (HDACi):** Given its role in the NuA4 complex, inhibitors that affect histone acetylation and deacetylation could modulate its activity indirectly.
- **Antineoplastic Agents:** Drugs targeting pathways involved in cellular proliferation and oncogenesis may impact RUVBL1 function, even if indirectly.

### 4. Pathways and Biological Processes
RUVBL1 is involved in multiple biological pathways:
- **Chromatin Remodeling and Histone Modification:** Component of NuA4 and SWR1-like complexes facilitating gene expression regulation through histone acetylation and the removal of histone variants.
- **DNA Repair Pathways:** Acts in recruiting repair machinery to sites of DNA damage, highlighting its role in maintaining genomic stability. 
- **Cell Cycle Regulation and Proliferation:** Essential for cell proliferation, implicating it in cell cycle progression and cancer development.
- **Transcription Regulation:** Modulates transcriptional activation processes connected to oncogenesis, apoptosis, and cellular stress response mechanisms.

In summary, RUVBL1 is a multifaceted protein that plays critical roles in fundamental biological processes, particularly related to transcription regulation, DNA repair, and cancer biology. Its involvement in age-related processes and interactions with other genes underscore its significance in both health and disease.