**ANKRD13C Gene Overview**

**Gene Symbol**: ANKRD13C  
**Location**: Perinuclear region of the cytoplasm; colocalizes with the endoplasmic reticulum (ER).

### 1. Associated Genes
ANKRD13C is known to interact with and affect the functioning of several other genes, especially those encoding for G protein-coupled receptors (GPCRs) due to its role as a chaperone. Some genes potentially associated with ANKRD13C include:

- **GPCRs**: Many GPCRs themselves, like those in the dopamine receptor family or adrenergic receptor family, may depend on ANKRD13C for proper folding and trafficking.
- **ANKRD13 Gene Family Members**: Other members of the ANKRD13 gene family, such as ANKRD13A and ANKRD13B, are functionally related and may have overlapping functions in receptor signaling or trafficking.

### 2. Aging and Age-related Diseases
There is limited direct data connecting ANKRD13C specifically to aging or age-related diseases; however, given its role in protein retention and regulation of receptor activity, it could theoretically influence pathways related to cellular stress responses, which are often implicated in aging. Alterations in GPCR signaling have been noted in age-related pathologies, such as neurodegenerative diseases (Alzheimer's, Parkinson's) and metabolic conditions, indicating that ANKRD13C may have indirect implications in these areas by regulating the proper signaling mechanisms affected during aging.

### 3. Drug Interactions
While specific drugs directly interacting with ANKRD13C may not be well-documented, it could influence the efficacy of drugs that target GPCRs, given its role in the chaperoning and signaling of these receptors. Classes of drugs or therapeutic approaches that may be affected include:

- **Antipsychotics**: Many of which act on dopaminergic or serotonergic pathways involving GPCRs.
- **Beta-blockers**: Targeting adrenergic receptors which are also GPCRs.
- **Angiotensin II Receptor Blockers (ARBs)**: Targeting the angiotensin pathway via GPCRs.

Given its potential involvement with GPCR networks, compounds targeting GPCR signaling pathways long-term may be relevant to consider in studies involving ANKRD13C.

### 4. Pathways and Biological Processes
ANKRD13C is involved in several key biological processes and signaling pathways:

- **Protein Retention in the ER**: Participates in ensuring that misfolded proteins do not exit the ER, thus maintaining cellular homeostasis.
- **Regulation of Anoikis**: Implicated in the process of programmed cell death that occurs when cells detach from the surrounding extracellular matrix, which is critical for various tissue remodelings and cancer progression.
- **Signal Transduction**: Given its role in GPCR biogenesis, ANKRD13C is involved in modulating various signaling pathways related to sensory perception (e.g., taste, smell) and hormonal responses.
- **Molecular Chaperoning**: Acts to prevent aggregation and misfolding of newly synthesized GPCRs and assists their proper maturation and transportation to the cell surface.

Overall, ANKRD13C plays a significant role in the cellular response mechanisms through its chaperoning functions, directly implicating it in receptor signaling regulation and, by extension, influencing numerous physiological processes.