### CPSF3 Gene Overview

**Official Gene Symbol**: CPSF3

**Location**: The CPSF3 gene is located on human chromosome 14.

**Function**: The CPSF3 gene encodes a protein that is a crucial component of the cleavage and polyadenylation specificity factor (CPSF) complex. This protein functions primarily as an endonuclease responsible for recognizing pre-mRNA cleavage sites, facilitating the post-transcriptional processing of mRNA, and is involved in the maturation of histone mRNAs and regulatory RNAs such as microRNAs (miRNAs). 

### 1. Associated Genes

CPSF3 is known to interact with several other genes and proteins, both directly and indirectly, particularly in the context of pre-mRNA processing and miRNA biogenesis. While the provided summary already mentioned some interactions, here are a few other genes/proteins associated with CPSF3:

- **ISY1**: Interacts in miRNA processing and embryonic stem cell differentiation.
- **U7 snRNP**: Involved in histone pre-mRNA processing.
- **CPSF1 and CPSF2**: Other components of the CPSF complex involved in polyadenylation.
- **MCPH1**: A gene associated with microcephaly that may interact in developmental processes.
- **DCP1A and DCP2**: Components of the decapping complex which may interact with the downstream cleavage products of mRNA.

### 2. Aging and Age-related Diseases

While specific studies directly linking CPSF3 to aging or age-related diseases may be limited, its functions suggest potential implications:

- **Cell Cycle Regulation**: CPSF3 is required for progression through S-phase, which is crucial for DNA replication and cell division. Disruptions in the cell cycle are often linked to aging and cancer.
- **MicroRNA Processing**: Since CPSF3 plays a role in the regulation of miRNAs, alterations in its function could affect gene expression profiles associated with aging and longevity as well as age-related pathologies, including neurodegenerative diseases.
- **Possible Cancer Link**: Given the essential role of CPSF3 in RNA processing and mRNA stability, dysregulation of CPSF3 has been associated with various cancers, particularly in the context of tumorigenesis and metastasis.

### 3. Drug Interactions

Currently, specific drugs or drug classes that directly interact with CPSF3 are not well characterized in detail. However, due to its role in essential cellular processes, several classes of compounds may indirectly affect CPSF3 activity:

- **Antineoplastic agents**: Chemotherapeutic drugs that target RNA synthesis or processing may affect CPSF3's activity due to its central role in mRNA maturation.
- **RNA polymerase inhibitors**: Drugs that modulate transcription may influence the processing functions of CPSF3 indirectly.
- **Potential targeting in gene therapies** or small molecules aimed at modulating splicing or RNA processing pathways might target components of the CPSF complex, including CPSF3.

### 4. Pathways and Biological Processes

CPSF3 is involved in a variety of critical biological pathways and processes, including:

- **mRNA Processing**: Key player in cleavage and polyadenylation of pre-mRNA, which is fundamental for mRNA maturation.
- **Histone mRNA 3'-end Processing**: Involved in the maturation of histone mRNAs that are essential for DNA packaging and regulation of gene expression during the cell cycle.
- **MicroRNA Biogenesis**: Essential for processing primary miRNAs, regulating gene expression in various developmental contexts.
- **Cell Cycle Regulation**: Participation in cellular mechanisms governing entry and progress through the cell cycle, specifically S-phase.

### Conclusion

CPSF3 is a pivotal gene for RNA processing, and its functions extend beyond mere pre-mRNA processing to encompass critical roles in gene regulation, cell cycle progression, and potentially, implications in aging and cancer. Continued research may reveal further insights into its clinical relevance and therapeutic targeting.