### RELA-DT Gene Overview

**Gene Symbol:** RELA-DT

The RELA-DT gene is known to be associated with the RELA gene, which encodes a subunit of the NF-κB transcription factor, crucial in various biological pathways including inflammation, immune responses, and cell survival. RELA-DT is a long non-coding RNA (lncRNA) that may be involved in regulating the expression and activity of nearby genes, particularly targeting inflammatory and immune response pathways.

### 1. Associated Genes
Besides RELA, RELA-DT may be associated with other genes including:

- **NF-κB subunits** such as RELB, NFKB1, and NFKB2, which are integral components of the NF-κB signaling pathway.
- **Cytokine genes**, due to its role in immune-related gene regulation. These may include TNF, IL-6, and IL-1β, which are pivotal in inflammation.

### 2. Aging and Age-Related Diseases
While direct studies linking RELA-DT with aging or specific age-related diseases are limited, the RELA gene itself has been implicated in several pathways that are critical in age-related conditions:

- **Chronic Inflammatory Diseases:** Given that NF-κB signaling is a key regulator of inflammation, RELA-DT may play a role in sustaining chronic inflammation often seen in aging.
- **Cancer:** The NF-κB pathway, through the activity of RELA, has ties to tumorigenesis, making RELA-DT of interest in understanding cancer progression in older adults.
- **Neurodegenerative Diseases:** Aberrant NF-κB signaling has been linked to neuroinflammation, which is a common hallmark of diseases like Alzheimer's.

### 3. Drug Interactions
While specific drug interactions directly targeting RELA-DT are not extensively cataloged, drugs and drug classes interacting with the NF-κB pathway may indirectly influence the expression of this lncRNA. Notable drug classes include:

- **Corticosteroids:** Anti-inflammatory drugs that may suppress NF-κB activity.
- **Non-steroidal anti-inflammatory drugs (NSAIDs):** These also influence inflammatory pathways in which RELA is involved.
- **Immunomodulatory agents:** Such as DMARDs (Disease-Modifying Anti-Rheumatic Drugs) that might influence the activity of NF-κB signaling and potentially RELA-DT as a downstream effect. 

### 4. Pathways and Biological Processes
The RELA-DT gene is involved in various biological processes, primarily related to:

- **NF-κB Signaling Pathway:** Central to the regulation of immune responses, cell proliferation, and survival.
- **Inflammatory Response:** This includes the regulation of pro-inflammatory cytokines and mediators.
- **Cell Survival and Proliferation:** RELA-DT's potential roles in modulating apoptosis and promoting survival in certain contexts.
- **Response to Stress:** Involved in cellular responses to oxidative stress and other forms of cellular damage.

### Conclusion
The RELA-DT gene, associated with RELA and the broader NF-κB signaling pathway, highlights the intersection between inflammation, immune responses, and age-related pathologies. The complexity of its interactions warrants further investigation to elucidate its precise roles in health and disease.