The KCTD20 gene encodes a member of the potassium channel tetramerization domain (KCTD) family, which is known for its role in various cellular functions through protein-protein interactions. Below is a more comprehensive overview of the KCTD20 gene, addressing your specific requests:

### 1. Associated Genes:
KCTD20 has been studied in context with several other genes, including but not limited to:
- **AKT (also known as PKB)**: KCTD20 promotes the phosphorylation of AKT family members.
- **GSK3 (Glycogen synthase kinase 3)**: Involved in signaling pathways that intersect with AKT.
- **PTEN**: Tumor suppressor gene that may have functional interactions with the pathways that KCTD20 influences.
- **FOXO1**: Forkhead box protein associated with the regulation of metabolism and longevity, possibly influenced by KCTD20 activity.

### 2. Aging and Age-Related Diseases:
While specific studies directly linking KCTD20 to aging or age-related diseases are limited, its role in the AKT pathway—known to be significant in processes like cell survival, metabolism, and growth—suggests potential implications in:
- **Cancer**: As KCTD20 is involved in the phosphorylation of AKT, alterations in this pathway have been linked to tumorigenesis.
- **Neurodegenerative diseases**: Changes in phosphorylation cascades (including AKT pathways) can impact neurodegeneration and cognitive decline with age.
- **Metabolic disorders**: Dysregulation of AKT signaling is closely associated with insulin signaling, obesity, and type 2 diabetes, conditions prevalent in older populations.

### 3. Drug Interactions:
KCTD20 itself may not have direct drug targets known in therapeutic contexts; however, its involvement in the AKT signaling pathway indicates that it could indirectly interact with drugs that affect AKT or related signaling pathways. Some classes of drugs include:
- **PI3K inhibitors**: Since the PI3K/AKT pathway is a critical cancer target, drugs that inhibit this pathway may affect KCTD20-associated processes.
- **Mtor inhibitors**: Targeting mTOR, which is downstream of AKT, could also have implications for KCTD20's activity.

### 4. Pathways and Biological Processes:
KCTD20 is implicated in various biological processes and pathways, including:
- **Regulation of cellular signaling pathways**: Particularly those relating to the AKT pathway, influencing cellular proliferation and survival.
- **Membrane-related processes**: As predicted to be an integral component of membranes, it may participate in membrane trafficking or signaling.
- **Phosphorylation events**: Positive regulation of phosphorylation processes linked to various substrates like AKT, which modulates a variety of cellular responses.

### Summary:
In summary, KCTD20 plays an essential role in various cellular mechanisms, particularly through its involvement in AKT phosphorylation. Its associations with other genes, potential implications in age-related diseases, and metabolic disorders make it a gene of interest in the realms of cancer research and aging-related studies. However, ongoing research is necessary to fully elucidate its functions and therapeutic potentials.