### ZIM2 Gene Overview

**Gene Symbol:** ZIM2  
**Gene ID:** 25730  
**Chromosomal Location:** Human chromosome 19

### 1. Associated Genes
In addition to **PEG3**, other genes that may be associated with ZIM2, particularly in relation to the imprinting domain, include:
- **ZIM1**: Another member of the ZIM gene family that may share regulatory roles.
- **DLK1**: A gene that is involved in growth regulation and also expressed from the paternal allele in the imprinted domain.
- **MEG3**: Engaged in transcriptional regulation and potentially linked to ZIM2 in the context of the imprinted gene cluster.

### 2. Aging and Age-Related Diseases
While direct associations between ZIM2 and aging or specific age-related diseases are less established compared to some other genes, there are a few insights:
- **Imprinting and Epigenetics:** Given its parental imprinting and role in transcriptional regulation, ZIM2 may be implicated in diseases where epigenetic factors play a significant role, such as certain cancers or neurological disorders. Changes in imprinted gene expression have been noted in age-related conditions.
- **Cancer Research:** As ZIM2 may be involved in cellular growth and differentiation, aberrations in its expression could be relevant in cancer biology, which is often linked to aging.

### 3. Drug Interactions
There are no specific drugs or drug classes directly associated with ZIM2 as of the latest information. However, since ZIM2 is suggested to be involved in transcriptional regulation, compounds that affect gene expression, such as certain cancer therapies targeting epigenetics or histone modification, may have indirect effects.

### 4. Pathways and Biological Processes
ZIM2 is considered to be involved in several biological processes, including:
- **Transcription Regulation:** The gene is likely engaged in the modulation of transcription for various genes, particularly those involved in growth and development.
- **Imprinting:** Its role within the imprinted gene network suggests a significant function in maintaining imprinting patterns and expression profiles during development.
- **Cell Growth and Differentiation:** Given its potential interactions with other imprinted genes, ZIM2 may influence cellular pathways related to growth and differentiation processes.

### Summary
The ZIM2 gene exemplifies the complexities of genomic imprinting and transcriptional regulation. While it shares common features with PEG3 in humans, differences in murine and bovine models highlight species-specific gene behavior and imprinting. Further studies are necessary to elucidate its exact roles, particularly in the context of aging and age-related conditions. To date, specific pharmacological agents directly targeting ZIM2 remain to be characterized, although its involvement in gene regulation positions it within broader therapeutic contexts, especially those targeting epigenetic mechanisms.