### Overview of the PRAG1 Gene

**Gene Symbol**: PRAG1  
**Location**: Chromosome 2q35  
**Function**: The PRAG1 gene encodes a protein that belongs to the tyrosine protein kinase family. While it is catalytically inactive, it functions as a scaffold protein, facilitating the assembly of signaling complexes. It is involved in several important cellular processes, particularly those related to neuronal development and signaling.

### 1. Associated Genes
While the summaries mention the association with RND2 (Rho family GTPase 2) and RhoA (Ras homolog gene family, member A), other genes that PRAG1 may interact with include:
- **CSK** (C-terminal Src kinase): Negative regulator of Src family kinases.
- **NOTCH**: Involvement in Notch signaling pathways.
- **Src family kinases (SFK)**: A group of non-receptor tyrosine kinases involved in various signaling pathways.

Additional potential interactions may involve proteins relevant to neuronal signaling, cytoskeletal dynamics, and cell motility. Specific interaction data from tools such as STRING or BioGRID could provide insights into further associated genes.

### 2. Aging and Age-Related Diseases
Current research has implicated PRAG1 in various age-related mechanisms, primarily through its roles in neuron function and signaling pathways that are modulated during aging. Some aspects include:
- **Neurite Outgrowth**: Alterations in neurite outgrowth can affect neural plasticity, influencing learning and memory, which tend to decline with age.
- **Notch Signaling**: Changes in Notch signaling have been associated with aging and age-related neurodegenerative diseases, such as Alzheimer's disease, where aberrations in cellular signaling pathways contribute to disease progression.
- **Cell Morphology and Motility**: Aging can impact cell morphology and motility, affecting tissue regeneration and maintenance, potentially linked to PRAG1's functions in these areas.

### 3. Drug Interactions
Currently, there are no specific drugs directly targeting PRAG1; however, it may be subject to modulation by drugs that affect:
- **Src-family Kinase Inhibitors**: Since PRAG1 influences SFK signaling, inhibitors of these kinases may indirectly affect PRAG1-related signaling pathways. Examples include Dasatinib and Bosutinib.
- **Notch Pathway Modulators**: Given PRAG1's role as a coactivator of Notch signaling, drugs that modulate Notch signaling (like gammasecretase inhibitors) could potentially interact with the functional pathways involving PRAG1.

### 4. Pathways and Biological Processes
PRAG1 is involved in several critical biological pathways and processes, including:
- **RhoA signaling pathway**: Regulates cytoskeletal dynamics and cell morphology.
- **Notch Signaling**: Impacts cell fate determination, particularly during development and differentiation.
- **Neuronal signaling**: Influences neurite outgrowth and neuronal development, which are crucial for maintaining neural networks.
- **Cell Motility**: Plays a role in processes that affect how cells move and interact, relevant for wound healing and tissue maintenance.

Overall, PRAG1's function as a scaffolding protein underscores its importance in various signaling pathways, particularly those linked to neuronal health and potentially aging processes. Continued study of PRAG1 may elucidate further its role in health and disease, especially in the context of neurodegeneration and aging.