### Gene Overview: OR1E3

**Gene Symbol:** OR1E3  
**Function:** OR1E3 encodes an olfactory receptor involved in the detection of odorant molecules, which initiates a neuronal response to enable the perception of smell. The gene belongs to a large family of G-protein-coupled receptors (GPCRs) that share a common structure characterized by seven transmembrane domains.

### 1. Associated Genes
Olfactory receptor genes, including OR1E3, have limited direct associations with other specific genes in the context of pathway or interaction analysis. However, they are part of a vast family of about 400 olfactory receptor genes in humans, typically categorized as follows:
- **Olfactory Receptor Genes (e.g., OR1E1, OR2A2, OR1E2)**
  
While not directly linked in function, these genes may exhibit overlapping expression patterns or contribute to similar sensory pathways.

### 2. Age-Related Associations
- **Olfactory Function and Aging:** Olfactory receptors, including OR1E3, have been studied in the context of aging; the sensory perception of smell can decline with age. Research indicates that degradation of olfactory receptor function is one of the earliest signs of neurodegenerative diseases, such as Alzheimer’s disease.
- **Potential Involvement in Age-Related Disorders:** While there may not be direct associations between OR1E3 and specific age-related diseases documented in databases, the overall sensory decline, involving olfactory receptors, could be indicative of broader neurodegenerative processes, highlighting the importance of olfactory function in maintaining cognitive health in aging populations.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes explicitly documented in association with the OR1E3 gene. However, it is worth noting that certain compounds that affect olfactory function may indirectly influence or modulate olfactory receptor activity. 

### 4. Pathways and Biological Processes
**Biological Processes Involved:**
- **Olfaction:** As a critical component of the olfactory system, OR1E3 plays a primary role in the recognition of volatile compounds and contributes to the signaling pathways responsible for odor perception.
- **Signal Transduction:** OR1E3 is involved in G-protein coupled receptor signaling pathways related to sensory perception, which includes activation of downstream signaling cascades upon binding of odorants.

**Involvement in Pathways:**
- **G-Protein Coupled Receptor Signaling Pathway:** This pathway covers the diverse roles of GPCRs in transmitting signals from outside the cell to the inside, involving various downstream effects that facilitate perception and response to external stimuli.
- **Sensory perception of smell (olfactory signaling pathway):** This pathway encompasses the molecular processes initiated by the binding of odorants to olfactory receptors, leading to neuronal activation and the eventual perception of smell.

### Summary
The OR1E3 gene is an essential component of the olfactory receptor family, contributing to the complex process of olfaction and sensory perception. Though direct associations with aging and specific diseases or drugs are less documented, its role in olfactory function and cognitive health amid aging remains an area of interest for ongoing research. Its participation in GPCR signaling pathways underscores its importance in sensory biology.