### Gene Overview

**Gene Symbol:** SNORD116-13  
**Gene Type:** Small nucleolar RNA (snoRNA)  
**Location:** Located in the Prader-Willi syndrome (PWS) locus on chromosome 15q11.2  

SNORD116-13 is one of the multiple small nucleolar RNAs (snoRNAs) involved in the biogenesis of ribosomes by facilitating the modification of rRNA. 

### 1. Associated Genes

SNORD116-13 is part of a cluster of related snoRNAs in the PWS locus, which includes several other snoRNAs, such as:

- **SNORD116-1 to SNORD116-12:** Part of the SNORD116 gene family, which is implicated in similar functions concerning rRNA modification and processing.
- **SNRPN (Small Nuclear Ribonucleoprotein N)**: This gene is also located in the PWS region and is known to be involved in RNA splicing and associated with PWS when deleted.

### 2. Aging and Age-Related Diseases

While there is limited direct information linking SNORD116-13 specifically to aging or age-related diseases, disturbances in the expression of genes in the PWS region, including SNORD116 snoRNAs, have been associated with various cellular aging mechanisms. Given that PWS affects various physiological processes, research suggests potential implications of snoRNAs in neurodevelopmental and metabolic regulation, which could correlate with age-related changes.

### 3. Drug Interactions

As of October 2023, there are no specific drugs or drug classes publicly known to interact directly with SNORD116-13. However, understanding epigenetic modification and the targeting of RNA processes may relate to general therapeutic approaches in diseases tied to PWS which could include the development of targeted drugs for RNA mechanisms.

### 4. Pathways and Biological Processes

SNORD116-13 is involved in multiple biological processes including:

- **Ribosome Biogenesis**: It is critical for the correct processing and modification of pre-rRNA.
- **RNA Modification**: SNORD116-13 is involved in the methylation of ribosomal RNA, which is crucial for the assembly of ribosomes and protein synthesis.
- **Cellular Response to Stress**: While further research is needed, snoRNAs have been implicated in the regulation of cellular response mechanisms, which might connect to stress responses in cells.

### Conclusion

Overall, SNORD116-13 is an essential part of the PWS-regulating snoRNA cluster and plays a critical role in RNA biogenesis and modification processes. It is part of broader cellular processes, potentially influencing age-related biological mechanisms despite a lack of direct links to aging or specific therapeutic targets as of the latest information available. Further research is necessary to fully elucidate its involvement in health and disease contexts.