### NKAIN3 Gene Overview

**Gene Symbol**: NKAIN3  
**Chromosomal Location**: Human Chromosome 11 (specifically at 11q13.5)  
**Protein Summary**: NKAIN3 is a member of the sodium-potassium ATPase interacting protein family and is known to interact with ATP1B1, the beta subunit of the Na+/K+ ATPase pump. This interaction suggests a potential role in modulating the activity of this important ion pump, which is essential for maintaining cellular ion homeostasis.

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### 1. Associated Genes

While the NCBI and UniProt summaries primarily mention the interaction with ATP1B1, NKAIN3 may also be associated with other genes involved in ion transport and signaling. However, specific gene associations beyond ATP1B1 are not well-characterized in current literature. Future studies may reveal further molecular partners or pathways involving NKAIN3.

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### 2. Aging and Age-Related Diseases

The information directly linking NKAIN3 to aging or age-related diseases is sparse. However, given that ion homeostasis is crucial for various physiological functions and alterations in ion transport mechanisms have been implicated in neurodegenerative diseases and cardiac disorders, NKAIN3 could indirectly influence age-related conditions. Research exploring the role of NKAIN3 in cellular stress responses or longevity mechanisms would be valuable.

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### 3. Drug Interactions

Currently, specific drugs or drug classes that directly interact with NKAIN3 have not been prominently characterized in the literature. However, given its functional relationship with the Na+/K+ ATPase complex, drugs that target this pathway, such as cardiac glycosides (e.g., digoxin) that inhibit Na+/K+ ATPase, might influence NKAIN3 activity in a broader pharmacological context.

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### 4. Pathways and Biological Processes

NKAIN3 is believed to participate in the following pathways and biological processes:

- **Ion Transport**: Involvement in processes that regulate ion exchange mechanisms, particularly in relation to sodium and potassium ions due to its interaction with Na+/K+ ATPase.
- **Cellular Homeostasis**: It may play a role in maintaining cellular ion balance and overall homeostasis.
- **Signal Transduction**: Given its potential interactions, NKAIN3 may be implicated in pathways related to cellular signaling processes influenced by ion gradients.

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Further experimental studies would provide more insight into NKAIN3's functional relevance in the proposed pathways and its possible roles in aging and disease contexts.