### RBM28 Gene Overview

**Gene Symbol:** RBM28  
**Description:** The RBM28 gene encodes a nucleolar protein that is an essential component of the spliceosomal small nuclear ribonucleoprotein (snRNP) complexes. It plays a critical role in the biogenesis and functioning of various snRNPs, including U1, U2, U4, U5, and U6, which are involved in mRNA splicing.

### 1. Associated Genes:
While the summaries provided do not list specific associated genes, RBM28 has shown interactions or associations with a variety of genes involved in splicing and RNA processing. Potentially associated genes that could be in the same pathways or functional networks as RBM28 include:

- **PRPF31** and **PRPF8:** Genes involved in pre-mRNA splicing, often associated with spliceosomal complexes.
- **SF3B1:** A gene linked to the splicing process and known for mutations associated with certain cancers.
- **SNRNP70:** One of the core components of the U1 snRNP complex, interacting closely with RBM28.
  
These associations highlight RBM28's role within the larger context of RNA splicing and ribonucleoprotein complex formation.

### 2. Aging or Age-related Disease Associations:
The RBM28 gene has not been explicitly linked to aging per se, but given its pivotal role in mRNA splicing and ribonucleoprotein function, there may be indirect implications on age-related diseases. Disruptions in splicing mechanisms are often implicated in:

- **Neurodegenerative Diseases:** Impaired RNA processing can exacerbate conditions such as Alzheimer's or frontotemporal dementia.
- **Cancer:** Age-related accumulation of mutations and alterations in gene expression driving tumorigenesis may involve pathways associated with splicing machinery.

Research into specific polymorphisms or mutations in RBM28 as they relate to aging is limited, but its functional role connects it to critical processes affected during aging.

### 3. Drug Interactions:
As of now, there are no specific drugs or drug classes directly known to interact with RBM28. However, general RNA splicing modifiers or small molecules that affect spliceosome function, such as:

- **Splicing Modulators:** These may indirectly affect RBM28 activity, though research into specific interactions with this gene is still developing.

### 4. Pathways and Biological Processes:
RBM28 is involved in several biological processes and signaling pathways, including:

- **mRNA Splicing:** A core function of RBM28 is facilitating the process of removing introns from precursor mRNA during transcription.
- **Ribonucleoprotein Complex Biogenesis:** RBM28 is essential for the assembly and stability of spliceosomal complexes, which are crucial for efficient and accurate gene expression.
- **Nuclear RNA Processing:** RBM28 plays a role in the post-transcriptional modification and processing of nuclear RNAs.

### Conclusion:
In summary, the RBM28 gene encodes a critical nucleolar component of spliceosomal snRNPs and has significant implications in RNA processing, with potential connections to broader pathways in cellular function, neurodegenerative diseases, and developmental syndromes. Continued research may shed light on its roles and interactions in health and disease, particularly in the context of aging and associated disorders.