### TBL3 Gene Overview

**Gene Symbol**: TBL3  
**Location**: Chromosome 3  
**Description**: The TBL3 gene encodes a protein that is a member of the WD40 repeat-containing protein family. This family is characterized by proteins that mediate protein-protein interactions, playing crucial roles in several cellular processes, including signal transduction, RNA processing, gene regulation, and ribosome biogenesis.

### 1. Associated Genes

While the NCBI and UniProt summaries don't specify direct associations, TBL3 is believed to interact with other genes involved in ribosome biogenesis and RNA processing. Notably, genes encoding ribosomal proteins such as RPS and RPL families may co-function with TBL3 during the assembly of ribosomal subunits. Other potential interacting partners might include:

- **NOC** (Nuclear Organelle/Cytoskeleton gene)
- **RRP** proteins (Ribosome biogenesis factors like RRP1, RRP5)
- **TAP** (Translation-associated protein)
  
These associations, however, need further functional validation and detailed studies to ascertain their significance.

### 2. Aging and Age-related Diseases

The direct relation between TBL3 and aging or age-related diseases is not extensively documented. However, defects in ribosome biogenesis, in which TBL3 is involved, have been associated with aging. Dysregulation of ribosomal protein genes has been observed in age-related disorders such as:

- **Neurodegenerative diseases**: Altered ribosomal processes can lead to neurodegeneration.
- **Cancer**: Aberrant ribosome biogenesis is often observed in cancer cells, and since TBL3 is involved in ribosomal assembly, changes in its expression or function might contribute to cancer progression or sensitivity.
- **Mitochondrial dysfunction**: As ribosomal activities decline with age, mitochondrial function may also be affected, linking TBL3 to mitochondrial-related age-related disorders.

### 3. Drug Interactions

As of now, there are no specific drugs or drug classes directly known to interact with TBL3 mentioned in the literature. However, drugs that target general processes of ribosome biogenesis or function, such as:

- **Antibiotics** (e.g., aminoglycosides and macrolides) that inhibit ribosomal function could indirectly influence the activity of TBL3.
- **Chemotherapeutics** that target rapidly dividing cells may also affect TBL3 due to its role in ribosome assembly, potentially making cancer cells hypersensitive to treatments.

### 4. Pathways and Biological Processes

TBL3 is involved in various key biological processes and pathways:

- **Ribosome Biogenesis**: Central role in the assembly of the small subunit processome in the nucleolus.
- **RNA Processing**: Involvement in the maturation of pre-rRNA.
- **Cytoplasmic RNA Processing Body (p-body) Regulation**: Functions that may intersect with general RNA stability and processing.
- **Cell Cycle Regulation**: Contributing to cellular growth and proliferation via ribosomal activities.
- **Response to Cellular Stress**: Its role in ribosome biogenesis is profoundly tied to how cells respond under various stress conditions, which can relate to aging and disease.

### Conclusion

The TBL3 gene plays a vital role in ribosome biogenesis and cellular regulation through its involvement in various processes. While precise details regarding direct drug interactions and aging-related implications are limited, the overall functionality aligns TBL3 with critical cellular mechanisms that may influence aging and age-related pathologies. Further research is warranted to better elucidate these aspects.