### RPEP3 Gene Overview

**Gene Symbol**: RPEP3
**Full Name**: Ribosomal Peptidyl-prolyl Isomerase RPEP3

The RPEP3 gene encodes a protein that is classified as a peptidyl-prolyl cis-trans isomerase. These types of enzymes play a crucial role in protein folding by catalyzing the isomerization of prolyl bonds in polypeptides. 

### Associated Genes

RPEP3 is known to interact with various genes through various biological pathways and processes. Here are some examples:

1. **RPS (Ribosomal Protein S)** - Proteins involved in ribosome structure and function.
2. **HSP (Heat Shock Proteins)** - Molecular chaperones that stabilize and refold denatured proteins.
3. **CYP (Cytochrome P450 Family)** - Enzymes involved in metabolizing drugs and other substances.
4. **P53** - A well-known tumor suppressor involved in cell cycle regulation.
5. **HSP90B1** - Another heat shock protein that may have interactions with RPEP3 in the context of protein folding and stability.

### Aging and Age-Related Diseases

The role of RPEP3 in aging and age-related diseases is not extensively documented, but as a peptidyl-prolyl isomerase, it may contribute indirectly to cellular processes that are affected with age, such as:

- **Protein misfolding diseases**: Given its role in protein folding, any dysfunction or decreased expression of RPEP3 could potentially lead to increased occurrence of misfolded proteins, which are associated with age-related diseases like Alzheimer's.
- **Cellular Stress Response**: Alterations in isomerase activity may influence stress responses necessary for longevity and maintenance of cell function.

Research is ongoing to establish a more direct relationship between RPEP3 and aging mechanisms, although specific findings related to this gene in the context of aging remain limited.

### Drug Interactions

As of the latest updates, there are no specific drugs directly targeting RPEP3 mentioned in the available literature. However, given its role in protein folding, it is conceivable that drugs that impact cellular stress responses or those that target protein homeostasis might engage pathways where RPEP3 functions are significant. Some classes of drugs that could potentially relate indirectly include:

- **Heat Shock Protein Modulators**: Drugs that influence the activity of HSPs could affect the function of RPEP3.
- **Proteostasis Regulators**: Compounds that improve protein folding and prevent aggregation might have an impact on RPEP3 functions.

### Pathways and Biological Processes

RPEP3 is associated with several critical biological processes, including:

- **Protein Folding**: As a peptidyl-prolyl isomerase, it helps in the proper folding of proteins, which is essential for their function.
- **Cellular Response to Stress**: RPEP3 may play a role in how cells respond to various stressors by facilitating proper protein folding under stress conditions.
- **Ribosome Biogenesis and Function**: The gene may have implications in the assembly and function of ribosomal proteins involved in translation.

### Summary

In summary, RPEP3 is a crucial protein-coding gene involved in protein folding and is likely connected to various cellular stress responses. While the direct association of RPEP3 with age-related diseases and particular drugs may need further clarification and research, its interactions with other proteins and genes underscore its importance in maintaining cellular function.