### NEURL1-AS1 Gene Overview

**Gene Symbol:** NEURL1-AS1  
**Gene Type:** Long non-coding RNA (lncRNA)  
**Location:** Chromosome 18

#### 1. Associated Genes
While the NCBI and UniProt summaries often highlight certain associations, NEURL1-AS1 has been implicated in regulatory networks involving various genes. Some notable associations include:

- **NEURL1:** This gene is closely related and it encodes a neuronal-specific protein that is thought to be involved in neuronal development and function.
- **ZEB1:** This gene is involved in epithelial-mesenchymal transition and has been associated with tumor progression. NEURL1-AS1 may be implicated in pathways affecting epithelial-mesenchymal transitions by regulating ZEB1.

There could be additional associations with genes involved in neuronal function and development, as well as potential regulatory targets associated with cancer and neurological diseases.

#### 2. Aging and Age-Related Diseases
There’s emerging evidence associating NEURL1-AS1 with aging and neurodegenerative diseases. Specifically:

- **Neurodegeneration:** Since NEURL1-AS1 is expressed in the nervous system, changes in its expression levels may affect neuronal health and contribute to conditions such as Alzheimer's disease and other forms of dementia.
- **Cell Senescence:** lncRNAs, including NEURL1-AS1, have been found to play roles in cellular senescence, which is a key factor in aging and the associated decline in cellular function.

Studies indicate that altered expression of NEURL1-AS1 correlates with age-related changes in gene expression, highlighting its potential role in cellular aging processes.

#### 3. Interacting Drugs or Drug Classes
Currently, there are no specific drugs documented to interact directly with NEURL1-AS1. However, the following drug classes may show relevance based on its functional associations:

- **Antineoplastic agents:** Given its potential links to cancer through regulatory pathways involving ZEB1, agents targeting tumor growth might indirectly influence NEURL1-AS1 expression.
- **Neuroprotective agents:** Drugs targeting neurodegenerative diseases could impact the pathways where NEURL1-AS1 is involved.

Further investigation into specific pharmacological interactions is needed for a more detailed understanding.

#### 4. Pathways and Biological Processes
NEURL1-AS1 is involved in several biological processes and pathways:

- **Regulation of Gene Expression:** As a long non-coding RNA, it likely functions as a regulator of gene expression, modulating transcriptional activities.
- **Neuronal differentiation and development:** Its expression in neurons suggests a role in neuronal function, development, and potentially in synaptic plasticity.
- **Cell signaling pathways:** It has been suggested that NEURL1-AS1 plays a role in cell signaling by interacting with pathways involved in cell growth and differentiation, particularly in neuronal cells and possibly in cancer.

#### Conclusion
Overall, NEURL1-AS1 remains an intriguing gene with potential implications in neurobiology and aging. Further research is essential to fully elucidate its role, particularly the complex regulatory mechanisms and its impact on age-related diseases and various therapeutic areas.