### PRICKLE2-DT Gene Overview

**Gene Symbol:** PRICKLE2-DT  
**Gene Type:** Long non-coding RNA (lncRNA)  
**Location:** Chromosome 12

The PRICKLE2-DT gene is a long non-coding RNA that originates from the PRICKLE2 genomic locus. Long non-coding RNAs are increasingly recognized for their roles in regulating gene expression and influencing various biological processes.

### 1. Associated Genes:
PRICKLE2-DT is known to be associated with the following genes:

- **PRICKLE2**: The protein-coding gene from which PRICKLE2-DT is derived. It plays roles in the Wnt signaling pathway and is involved in the establishment of cell polarity.
- **DVL2**: Involved in the Wnt signaling pathway, which is crucial for various developmental processes.
- **CTNNB1**: Also involved in Wnt signaling, encoding β-catenin, which is a key player in the pathway.
- **SNAI1**: This gene encodes the protein snail, which is involved in epithelial-mesenchymal transition (EMT), critical for development and metastasis in cancer.
- **WNT3A**: A signaling molecule active in the Wnt pathway.

### 2. Aging and Age-Related Diseases:
Research suggests that lncRNAs, including PRICKLE2-DT, may be involved in processes related to aging and age-related diseases. While specific findings directly linking PRICKLE2-DT to aging are limited, the associated gene PRICKLE2 has been implicated in neurodevelopment and may play a role in neurodegenerative diseases such as Alzheimer’s, which are often age-related. The dysregulation of the Wnt signaling pathway (involving PRICKLE2) can affect cellular processes such as proliferation, differentiation, and survival—all of which are relevant to aging.

### 3. Drug/Drug Classes Interaction:
Currently, there are no specific drugs or drug classes explicitly listed as known interactions with PRICKLE2-DT. However, as it is linked to pathways such as Wnt signaling, drugs that target components of this pathway (e.g., Wnt pathway inhibitors or activators) may indirectly influence the expression or function of PRICKLE2-DT through their actions on associated genes like PRICKLE2 or DVL2.

### 4. Pathways and Biological Processes:
PRICKLE2-DT is implicated in several biological processes, often via its association with the PRICKLE2 gene and the Wnt signaling pathway. Key pathways and processes include:

- **Wnt Signaling Pathway**: Critical for various developmental processes and regulation of gene expression, cell proliferation, and differentiation.
- **Cell Polarity Establishment**: Involves processes that determine the spatial organization of cells and their architecture in tissues.
- **Neuronal Development**: Involvement in neural patterning and morphogenesis.

Understanding the precise roles and mechanisms of PRICKLE2-DT, along with its interacting partners and implications in health and disease, remains an active area of research. The functional analysis of this lncRNA and its interplay with other molecules will advance the understanding of complex biological processes and disease states related to aging.