ZFHX4-AS1 is a long non-coding RNA (lncRNA) gene located on chromosome 16. It is primarily implicated in gene regulation and has been noted for its potential role in various biological processes, particularly those related to gene expression modulation.

### 1. Associated Genes
ZFHX4-AS1 has been found to be associated with several genes, including but not limited to:
- **ZFHX4**: The primary protein-coding gene located near ZFHX4-AS1, where it is believed that ZFHX4-AS1 may regulate the expression of ZFHX4.
- **PTEN**: In some studies, ZFHX4-AS1 has been shown to have regulatory roles influencing the expression of PTEN, a well-known tumor suppressor gene.
- **TP53**: There might be indirect associations where ZFHX4-AS1 impacts the pathways involved in the activity of TP53 via its influence on ZFHX4 or other regulatory genes.

### 2. Aging and Age-related Diseases
Research suggests that lncRNAs like ZFHX4-AS1 may be involved in developmental processes and the regulation of cellular senescence. Overexpression or downregulation of certain lncRNAs has been linked to age-related diseases, including various cancers and degenerative diseases. Though specific studies focusing solely on ZFHX4-AS1 in the context of aging are limited, its involvement in pathways that influence cellular behavior could suggest a role in the aging process and related disorders.

### 3. Drug Interactions
Currently, there is no comprehensive list of specific drugs that directly interact with ZFHX4-AS1 reported in the literature. However, due to its regulatory role over genes like PTEN, it is plausible that compounds or therapies targeting these pathways (like PI3K inhibitors or others affecting the PTEN signaling pathway in cancer therapy) may indirectly interact with the expression or activity of ZFHX4-AS1.

### 4. Pathways and Biological Processes
ZFHX4-AS1 is involved in several biological processes and signaling pathways, mainly those related to:
- **Regulation of gene expression**: It acts as a regulatory element, influencing the transcription of nearby genes including its sense transcript (ZFHX4).
- **Cell differentiation and development**: Some studies suggest a role in the regulation of stem cell differentiation pathways.
- **Onco-suppressor pathways**: By influencing the expression of tumor suppressor genes, it may be a player in cancer progression pathways.

In summary, ZFHX4-AS1 is a lncRNA with potential regulatory roles linked to other genes such as ZFHX4 and PTEN, with implications in aging processes and possible interactions with cancer therapies. However, research is still developing, and more studies will help clarify its precise functions and therapeutic targets.