The **SCAPER** gene (S-phase cyclin A2-associated protein, also known as S-phase cyclin A2-associated protein in humans) is involved in the regulation of the cell cycle, specifically in the transition from G1 to S phase. Below are further details related to your query on this gene:

### 1. Associated Genes
SCAPER has several interactions and associations with other genes, particularly those involved in cell cycle regulation and cancer biology. Some notable genes associated with SCAPER include:
- **CCNA2** (Cyclin A2): The primary interacting partner that SCAPER regulates by retaining it in the cytoplasm to control cell cycle progression.
- **CDK2** (Cyclin-dependent kinase 2): An important partner of cyclins in driving the cell cycle.
- **MCM proteins** (e.g., MCM2-7): These proteins are critical for DNA replication and have been noted in association with SCAPER in the context of S-phase regulation.
- Other cell cycle regulators such as **AURKA** (Aurora kinase A) and **CDC6** (Cell Division Cycle 6).

### 2. Aging and Age-related Diseases
There is emerging evidence suggesting a potential role for SCAPER in aging and age-related diseases, particularly in the context of cancer. Alterations in cell cycle regulation, including those involving SCAPER, contribute to cellular senescence and tumorigenesis. Dysregulation of SCAPER expression has been associated with:
- **Cancer**: Overexpression of SCAPER has been implicated in multiple cancers, suggesting it may play a role in tumor proliferation and survival.
- **Cellular senescence**: Changes in SCAPER regulation could influence the onset of cellular aging and senescence-associated phenotypes, potentially impacting tissue repair mechanisms and age-related degenerative diseases.

### 3. Drug and Drug Classes Interaction
While there are no specific drugs that target SCAPER directly, its involvement in the cell cycle and cancer suggests that:
- **CDK inhibitors** (e.g., Palbociclib, Ribociclib) that target CDK2-cyclin complexes may affect SCAPER-related pathways indirectly.
- Research into targeted therapies in cancers (especially treatments involving cell cycle modulation) may lead to further discoveries regarding SCAPER interactions.

### 4. Pathways and Biological Processes
SCAPER is involved in several key biological processes, including but not limited to:
- **Cell cycle regulation**: Specifically, it plays a crucial role in controlling the activity of cyclin A2 and thus contributes to the regulation of the passage through S-phase.
- **DNA replication**: As part of its function in the cell cycle, SCAPER is indirectly involved in DNA replication processes.
- **Cell proliferation**: Through its regulatory actions, SCAPER influences overall cell proliferation rates and integrity.
- **Response to stress**: Some studies suggest involvement in cellular responses to DNA damage and stress, thereby linking it to processes of genomic stability.

Overall, SCAPER serves as a significant regulatory protein within the cell cycle, with implications in cancer biology and the potential influence on aging-related processes. Further research is needed to fully elucidate its roles and therapeutic potentials.