### GPR65 Gene Summary

**Gene Symbol:** GPR65  
**Location:** Plasma Membrane  
**Function:** G protein-coupled receptor activity.  
**Key Roles:**
- Receptor for glycosphingolipids (e.g., psychosine, PSY).
- Involved in immune responses and maintaining lysosomal function.
- Supports phagocytosis-mediated clearance of intracellular bacteria.
- Potential role in the activation-induced cell death and differentiation of T-cells.

### 1. Associated Genes
GPR65 is known to potentially interact or be associated with several other genes, particularly those involved in immune functions and T-cell signaling pathways. Some relevant genes include:

- **CD28:** A costimulatory molecule that plays an important role in T-cell activation.
- **PTEN:** Involved in regulating cell survival and apoptosis, may interact in pathways influenced by GPR65 signaling.
- **RhoA:** A small GTPase that regulates actin cytoskeleton reorganization, which GPR65 is known to influence.
- **IL2:** Interleukin-2, involved in T-cell proliferation and differentiation, which may be regulated in part by GPR65 activity.

### 2. Aging and Age-Related Diseases
Research on GPR65 in the context of aging is less pronounced, but there are a few relevant points:

- **Immune Function:** GPR65's role in T-cell differentiation and apoptosis could implicate it in age-related declines in immune function, a phenomenon known as immunosenescence.
- **Neurodegenerative Diseases:** Dysregulation of the glycosphingolipids’ metabolism, which is related to GPR65, has been associated with conditions like Alzheimer's disease. Psychosine is implicated in certain forms of neurodegeneration, especially in disorders affecting lysosomal function.

### 3. Drug Interactions
While specific drug interactions directly targeting GPR65 are not extensively documented, the receptor being part of G protein-coupled receptors suggests potential links to certain drug classes:

- **Immunomodulators:** Drugs that modify the immune response may indirectly influence GPR65 activity due to its role in immune cell function.
- **Lysosome Stabilizers:** Compounds that stabilize lysosomal function or enhance clearance mechanisms in cells could be relevant, considering GPR65's contribution to maintaining lysosome function.

### 4. Pathways and Biological Processes
GPR65 is involved in several pathways and biological processes, including:

- **Glycosphingolipid metabolism:** Participating in the signaling and metabolism of glycosphingolipids.
- **Immune system:** Involvement in T-cell development and activation, as well as broader immune response regulation.
- **Actin cytoskeleton organization:** Influencing processes like cell migration and shape through stress fiber assembly and reorganization.
- **Phagocytosis:** Playing a role in the cellular process of engulfing pathogens and debris.

### Conclusion
The GPR65 gene encodes a G protein-coupled receptor crucial for various immune responses, particularly in T-cell function and lysosomal maintenance. Ongoing research may provide further insights into its connections with aging, disease, and therapeutic targeting.