### ABCC10 Gene Overview

**Gene Symbol**: ABCC10

**Location**: The ABCC10 gene is located on human chromosome 16q12.1.

**Protein Features**: The ABCC10 protein is primarily characterized as an ATP-dependent transporter, which belongs to the ABC (ATP-Binding Cassette) transporter superfamily, specifically the MRP (Multidrug Resistance Protein) subfamily. It mediates the transport of various physiological and xenobiotic compounds across cell membranes.

### 1. Associated Genes

While the NCBI and UniProt summaries do not explicitly mention other genes, ABCC10 is often studied in relation to other transporters and genes involved in drug metabolism and resistance, such as:

- **ABCC1** (also known as MRP1): This gene encodes another Member of the MRP subfamily involved in the extrusion of drugs and endobiotics.
- **ABCB1** (P-glycoprotein): This is another well-studied multidrug resistance transporter that works synergistically with ABCC10 in drug disposition mechanisms.
- **UGT2B7**: This gene may have interactions with ABCC10 in the context of glucuronidation processes.
  
### 2. Age-Related Associations

While direct associations of ABCC10 with aging or age-related diseases are still under investigation, some potential connections include:

- **Cancer**: As ABCC10 plays a role in multidrug resistance, its expression may impact the efficacy of chemotherapy in older adults, who often experience higher rates of cancer and may be more susceptible to drug-related toxicity.
- **Metabolic Diseases**: Alterations in transporters, including ABCC10, can influence drug metabolism and disposition in the aging population, possibly affecting the management of chronic conditions, including cardiovascular diseases.
- **Neurodegeneration**: Limited studies suggest that transporters like ABCC10 might have roles in the movement of molecules tied to neurodegenerative processes, but further specific research is needed to clarify these links.

### 3. Drug Interactions

ABCC10 is notably implicated in conferring resistance to several chemotherapeutic agents, including:

- **Docetaxel**: A widely used cancer treatment, particularly in breast and prostate cancer.
- **Paclitaxel**: Another chemotherapeutic agent that is subject to resistance mediated by ABCC10.
Additionally, ABCC10 may interact with other drug classes or compounds but does not transport certain substances including glycocholic acid, taurocholic acid, methotrexate (MTX), folic acid, cyclic AMP (cAMP), or cyclic GMP (cGMP).

### 4. Pathways & Biological Processes

ABCC10 is associated with several key biological processes:

- **Transport**: As an ABC transporter, it is involved in both the transport of metabolites such as ions and drugs across membranes.
- **Drug Resistance**: It plays an essential role in multi-drug resistance mechanisms in various cancers.
- **Detoxification**: ABCC10 is involved in the detoxification processes by extruding harmful compounds from cells, which is crucial for cellular homeostasis.
- **Glucuronidation**: The transporter is vital for the movement of glucuronide conjugates, influencing the metabolism of steroid hormones like estradiol.

### Conclusion

The ABCC10 gene encodes a critical protein for the transport of numerous endogenous and exogenous compounds, primarily influencing drug resistance mechanisms in cancer treatment. Its interactions and potential implications in aging and age-related diseases underscore the need for further studies to elucidate its full biological significance.