### RHOQ-AS1 Gene Overview

**Gene Symbol:** RHOQ-AS1

**Summary:**  
RHOQ-AS1 encodes a long non-coding RNA (lncRNA) that is antisense to the RHOQ gene, which encodes for the Rho family GTPase, RHOQ. LncRNAs are involved in the regulation of gene expression and are implicated in various biological processes and diseases.

### 1. Associated Genes

While RHOQ is the primary gene associated with RHOQ-AS1 due to its antisense nature, other potential associations (through pathways or co-expression) may include:

- **RHOQ (Rho family GTPase)**: As the target of the antisense transcript.
- **Other Rho family genes**: Such as RHOA, RHOB, RHOC, which may be involved in similar signaling pathways.
- **Genes involved in lncRNA regulatory functions**: These might include epigenetic modifiers or transcription factors influenced by the RHOQ-AS1 expression.

### 2. Aging and Age-Related Diseases

**Known Details Related to Aging:**
Research on lncRNAs in general suggests that they play roles in cellular homeostasis and may influence aging processes through modulation of gene expression. Although specific studies on RHOQ-AS1 may be limited, lncRNAs have been implicated in various age-related phenomena such as:

- **Cellular senescence**: Regulation of pathways linked to cellular aging.
- **Tissue regeneration**: Potential roles in pathways that affect tissue repair and stem cell function.

RHOQ itself has been noted in certain studies to be involved in cancer and cardiovascular diseases, which are often diseases associated with aging. More research is needed to specifically elucidate any direct connections of RHOQ-AS1 with aging or age-related diseases.

### 3. Drug Interactions

As of the latest data (up to October 2023), direct interactions of drugs or drug classes specifically targeting RHOQ-AS1 are not well documented. However, the following classes of drugs may indirectly interact through pathways influenced by RHOQ, particularly in the context of cancer treatment:

- **Chemotherapeutic agents**: As changes in RHOQ expression can affect cancer cell signaling.
- **Targeted therapies**: During investigations into the modulation of Rho GTPases in cancer therapies.

### 4. Pathways and Biological Processes

**Pathways and Processes:**
RHOQ-AS1 might be involved in several key biological processes, including but not limited to:

- **Cell migration and adhesion**: Due to its association with Rho GTPase function, which is critical for cytoskeletal rearrangements.
- **Regulation of gene expression**: As an antisense lncRNA, it may modulate the transcriptional activity of its sense gene (RHOQ) or neighboring genes.
- **Involvement in signaling pathways**: Such as those mediating cell proliferation, survival, and differentiation.

**Specific Pathways**:
- **Rho GTPase signaling**: Including pathways related to cancer progression and metastasis.
- **Cell cycle regulation and apoptosis**: Potential influence through modulation of RHOQ and other related signaling pathways.

### Conclusion

RHOQ-AS1 is an important lncRNA that may have significant implications in gene regulation related to the RHOQ protein, and it might play roles in cellular processes relevant to aging and disease. Further research is essential to illuminate its precise functions, associated genes, interactions, and implications in health and disease.