### NAA80 Gene Overview

**Gene Symbol**: NAA80  
**Location**: Chromosome 3p21.3  
**Family**: N-acetyltransferase (NAT) family  
**Functions**: Catalyzes the acetylation of N-terminal methionine of proteins, especially beta-actin (ACTB) and gamma-actin (ACTG). This modification is crucial for regulating actin dynamics and overall cytoskeletal organization.

### 1. Associated Genes
While the summarised information primarily focuses on NAA80 interacting with beta-actin and gamma-actin, other associated genes and proteins that may have functional or regulatory implications include:

- **ACTB (Beta-actin)**: Central to cell structure and motility.
- **ACTG (Gamma-actin)**: Plays a role in cell shape and motility.
- **Hyaluronoglucosaminidase 3 (HYAL3)**: Overlapping gene on the same strand, potentially sharing regulatory mechanisms or expression patterns.
- Additional genes involved in actin regulation or processing may be considered, especially those related to the cytoskeletal dynamics, but specific associations with NAA80 beyond those listed may require more targeted research.

### 2. Aging and Age-Related Diseases
Currently, there is limited direct literature specifically linking NAA80 to aging or age-related diseases. However, deregulation of actin dynamics and its post-translational modifications have been implicated in:

- **Cancer**: Alterations in cytoskeletal dynamics can promote cancer cell motility and metastasis. Given that NAA80 may behave as a tumor suppressor, its dysregulation could indirectly influence oncogenesis as part of the aging process.
- **Neurodegenerative Diseases**: Changes in actin acetylation could affect neuronal function and resilience, with implications for diseases such as Alzheimer's and Parkinson's, where cytoskeletal integrity is disrupted.

To date, more detailed studies would be beneficial to conclusively tie NAA80 to specific aging processes or diseases.

### 3. Drug Interactions
As with many genes involved in cellular processes such as acetylation, direct drug interactions specifically with NAA80 are not prominently documented. However, potential indirect interactions may exist through:

- **Histone Deacetylase Inhibitors (HDACi)**: Since these compounds influence acetylation processes broadly, they could potentially affect NAA80-related pathways.
- **Chemotherapeutics**: Drugs that influence actin dynamics, such as cytochalasins or latrunculins, may indirectly engage with the functional network surrounding NAA80.

### 4. Involvement in Pathways and Biological Processes
NAA80 is known to be involved in several biological processes, including:

- **Actin Cytoskeleton Organization**: Facilitates proper assembly and dynamics of actin filaments.
- **Protein Acetylation**: Specifically, it participates in N-terminal acetylation of proteins, influencing their stability and function.
- **Cell Motility and Adhesion**: Changes in actin modifications can impact how cells interact with one another and their extracellular matrix.
- **Tumor Suppression Pathways**: Acts as a modulator in cancer-related pathways, possibly impacting pathways involved in cell cycle regulation and apoptosis.

### Conclusion
The NAA80 gene plays a crucial role in protein acetylation, particularly regarding actin dynamics and cellular architecture. Although direct associations with aging are currently less defined, its cancer-related implications and association with cytoskeletal processes suggest a significant biological impact potentially relevant to age-associated pathologies. Further studies are warranted to elucidate its full scope of function and therapeutic potential.