### PRKAR2A-AS1 Gene Overview

**Gene Symbol:** PRKAR2A-AS1  
**Type:** Long Non-Coding RNA (lncRNA)

#### Summary
PRKAR2A-AS1 is an antisense RNA that is associated with the PRKAR2A gene, which encodes a regulatory subunit of protein kinase A (PKA). The lncRNA is known to play a role in the regulatory functions concerning gene expression.

### 1. Associated Genes
While the summaries provided from NCBI and UniProt primarily focus on the PRKAR2A gene association, PRKAR2A-AS1 may also interact or be associated with other genes involved in signaling pathways, transcription regulation, and cellular processes. These might include:
- **PRKAR2A**: Directly associated, as the antisense lncRNA is complementary to this gene.
- **PIK3CA**: Altered in various cancers and may interact with signaling pathways affected by PRKAR2A-AS1.
- Any other target genes involved in PKA signaling, such as **AKT1** and genes in the cAMP pathway.

### 2. Aging and Age-Related Diseases
While direct studies focusing on PRKAR2A-AS1 specifically in the context of aging or age-related diseases may be limited, the PRKAR2A gene itself is implicated in various cellular processes that are essential for tissue homeostasis and response to stress. Dysregulation of PKA signaling is linked with age-related diseases such as:
- **Cancer**: Alterations in the PRKAR2A signaling pathway can lead to growth and apoptosis resistance.
- **Cardiovascular Diseases**: Age-related changes in cardiac signaling are influenced by regulatory mechanisms involving PKA.
- **Neurodegenerative Diseases**: Implications in neuroprotective signaling pathways.

### 3. Drug Interactions
Information specific to drug interactions with PRKAR2A-AS1 is sparse, but potential areas of pharmacological interest may include:
- **PKA Inhibitors**: Given the association with PRKAR2A, drugs that modulate PKA signaling could indirectly affect the expression or function of this lncRNA.
- **cAMP Modulators**: Compounds that alter cAMP signaling pathways may also affect the regulatory networks involving PRKAR2A-AS1.

### 4. Pathways and Biological Processes
PRKAR2A-AS1 is implicated in several pathways and biological processes, primarily due to its regulation of the PRKAR2A gene and PKA signaling, including:
- **cAMP signaling pathway**: Involvement in the modulation of signaling cascades.
- **Regulation of Gene Expression**: As an antisense RNA, it could play a role in transcriptional regulation and chromatin modification.
- **Cell Growth and Differentiation**: As part of signaling networks, it may influence cellular proliferation and differentiation processes.

**Note:** Further research and more concrete studies would be necessary to fully elucidate the specific roles and mechanisms of PRKAR2A-AS1 in these processes, particularly regarding its influence in aging and disease contexts.