### Gene Overview: RPL13AP25

**Gene Symbol:** RPL13AP25  
**Description:** RPL13AP25 is a pseudogene related to ribosomal protein L13 (RPL13). Pseudogenes are often non-functional sequences that resemble functional genes but typically do not encode proteins.

### 1. Associated Genes

RPL13AP25 is associated with several other genes within the ribosomal protein family and pseudogene complexes, including:

- **RPL13** - The functional gene encoding the ribosomal protein L13.
- Other ribosomal protein genes such as RPL13A, RPL12, RPL14, and potentially non-coding RNAs that participate in ribosome biogenesis.

### 2. Aging and Age-related Diseases

While RPL13AP25 itself is a pseudogene and may not directly contribute to disease mechanisms, disruptions in ribosomal protein synthesis and pseudogene function have been implicated in various age-related conditions. Ribosomopathy, a class of diseases stemming from defects in ribosomal proteins, can influence cell proliferation and contribute to diseases such as cancer and neurodegenerative disorders.

Reviewing literature related to RPL13 and its associated pathways may provide insights into its potential indirect roles in aging and associated diseases, although explicit links to RPL13AP25 specifically remain underexplored and not well-documented.

### 3. Drug Interactions

There are currently no specific drugs or drug classes directly associated with RPL13AP25, likely due to its pseudogene status. However, drugs that target ribosomal function or protein synthesis, such as:

- Antibiotics (e.g., tetracyclines or aminoglycosides)
- Chemotherapy agents (e.g., those targeting ribosome biogenesis in cancer cells)

may have indirect interactions as they affect the overall ribosomal activity in which RPL13 and related ribosomal proteins are involved.

### 4. Pathways and Biological Processes

RPL13AP25 is not directly involved in any defined biological pathways due to its classification as a pseudogene. Nevertheless, it is associated with several biological processes that involve ribosomal functions:

- **Ribosome biogenesis:** The process of assembling ribosomes from rRNA and ribosomal proteins.
- **Translation:** The synthesis of proteins from messenger RNA (mRNA) templates, in which the functional ribosomal processes, including those involving RPL13, participate.

The role of pseudogenes like RPL13AP25 in regulating their homologous functional genes and influencing gene expression may also have implications in cellular processes, even though they are not directly involved.

**Note:** The exploration of pseudogenes, including RPL13AP25, is an evolving field. Its functional implications may become clearer with further research.