### RBMXL3 Gene Overview

**Gene Symbol:** RBMXL3  
**Location:** Encoded within an intron of the LRCH2 gene, located on chromosome 21.

#### Function and Characteristics:
RBMXL3 (RNA binding motif protein, extra-long 3) is characterized by its predicted roles in RNA biology, particularly:
- mRNA binding activity.
- snRNA binding activity.
- Involvement in mRNA splicing via the spliceosome.
- Part of the U12-type spliceosomal complex.

#### Associated Genes:
RBMXL3 is not frequently reported to be directly associated with specific genes outside of its primary role. However, given its function in the spliceosomal process, it may have indirect relationships with genes undergoing alternative splicing. Investigation into spliceosomal complex components such as:
- U5 snRNP components (e.g., RNU5A, RNU5B)
- U12 snRNP components.

Furthermore, as spliceosomal dysfunction is a feature in several diseases, it may indirectly be associated with genes implicated in cancer, neurodegenerative diseases, and other conditions linked to impaired RNA processing.

#### Aging and Age-Related Diseases:
While there are no specific, well-defined studies directly attributed to RBMXL3 regarding aging or age-related diseases, general spliceosome activity has implications in cellular aging. Abnormalities in mRNA splicing have been shown to contribute to the pathogenesis of various age-related diseases, including cancer and neurodegeneration. Therefore, RBMXL3 may play a role in mediating such processes indirectly through its function in splicing.

#### Drug Interactions:
As of now, there are no specific drug interactions exclusively associated with RBMXL3 reported in major databases. However, drugs targeting splicing alterations (e.g., spliceosome modulators) may have a global impact on genes like RBMXL3, particularly in disease contexts such as cancer.

#### Pathways and Biological Processes:
RBMXL3 is primarily involved in:
- mRNA splicing: Essential for the correct processing and maturation of pre-mRNA.
- RNA processing: A fundamental aspect of gene expression regulation.
- U12-type spliceosome function: Involvement in the rare class of spliceosomes, specifically handling non-canonical introns in some gene transcripts.

In summary, while specifically tailored information on RBMXL3 in relation to associated genes, aging, drug interactions, and pathways is limited, its role in spliceosomal activity places it within a broader context of RNA biology and potential implications in health and disease. Further research may elucidate its functional impact more thoroughly.