### EPS15-AS1 Gene Overview

**Gene Symbol:** EPS15-AS1  
**Full Name:** Epidermal growth factor receptor pathway substrate 15 antisense RNA 1

**Summary:**
EPS15-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various biological processes, particularly those related to cancer biology, cell proliferation, and cellular response to stress. The gene is situated on chromosome 1 and is transcribed from the opposite DNA strand of the EPS15 gene, which encodes a protein involved in the regulation of receptor-mediated endocytosis.

### 1. Associated Genes

While detailed associations can be complex, EPS15-AS1 is known to be associated with several other genes, including:

- **EPS15**: The protein-coding counterpart linked to various cellular processes.
- **EGFR**: As part of signaling pathways influencing cellular growth and survival.
- **PTEN**: Involved in regulating the cell cycle and preventing tumor formation.
- **TP53**: A well-known tumor suppressor associated with regulation of the cell cycle and apoptosis.

### 2. Aging and Age-Related Diseases

Research indicates that lncRNAs such as EPS15-AS1 may play significant roles in the processes of aging and age-related diseases. Some potential associations include:

- **Cancer**: The expression levels of EPS15-AS1 have been linked to various cancers, suggesting a role in tumor progression and metastasis, which are often influenced by aging.
- **Inflammation and Metabolism**: Age-related changes in cellular functions, particularly inflammatory pathways and metabolic regulation, may be influenced by the modulation of this lncRNA.
- **Neurodegenerative Diseases**: Early studies have suggested correlations between lncRNA expression profiles in aging individuals and conditions like Alzheimer's disease, where EPS15-AS1 may contribute to disease pathogenesis.

### 3. Drug Interactions

As of my last update, EPS15-AS1 itself is a non-coding RNA, meaning it does not encode a protein that serves as a direct drug target. However, due to its role in cancer and various biological pathways, it might interact indirectly with drugs that target those pathways. Some potential drug classes that may be affected by the regulatory effects of EPS15-AS1 include:

- **Chemotherapy agents** (due to its involvement in cancer progression)
- **Targeted molecular therapies** (particularly those targeting EGFR or pathways influenced by PTEN and TP53)

Specific drugs directly targeting lncRNA EPS15-AS1 are currently not well characterized.

### 4. Pathways and Biological Processes

EPS15-AS1 is involved in several key pathways and biological processes, including:

- **EGFR Signaling Pathway**: Plays critical roles in cell differentiation, proliferation, and survival. EPS15-AS1 modulation may alter responses to EGFR-targeted therapies.
- **Endocytosis**: Given its association with the EPS15 gene, it is likely involved in receptor-mediated endocytosis processes.
- **Cell Cycle Regulation**: Involvement in progression and checkpoint control, influencing apoptosis and growth signaling.
- **Apoptosis**: There are indications of its role in influencing apoptotic pathways, which are crucial in cancer biology.

Overall, EPS15-AS1 represents a significant area of interest for ongoing research, particularly in understanding its role in gene regulation, cancer biology, and potential implications for aging and age-related diseases. Further studies are essential to fully elucidate the breadth of its functions and interactions.