The FAM83A-AS1 gene, also referred to as "FAM83A antisense RNA 1," is a long non-coding RNA (lncRNA) that plays a significant role in various biological processes. Below are detailed insights into this gene, including associations, implications for aging, drug interactions, and related pathways.

### 1. Associated Genes

While the NCBI and UniProt summaries may not explicitly mention associations, FAM83A-AS1 is often studied in the context of the FAM83A gene, which encodes a protein involved in signaling pathways. Research suggests that FAM83A-AS1 may influence the expression of FAM83A and other nearby genes in its chromosomal location, such as:

- **FAM83B**: Another gene in the FAM83 family, known to participate in signaling and developmental processes.
- **FAM83C**: Similar functions as FAM83A, potentially in cell signaling pathways.

Additionally, it may interact with genes involved in cancer progression, which can also relate to metastasis or tumor growth regulation.

### 2. Details on Aging and Age-Related Diseases

FAM83A-AS1 has been associated with various cancers, and its expression may correlate with tumor stages, indicating its role in oncogenesis. There is emerging research suggesting lncRNAs, including FAM83A-AS1, may have implications in age-related diseases such as:

- **Cancer**: Studies have shown that FAM83A-AS1 may correlate with the progression of different types of cancer, including breast and colorectal cancer. The changes in expression levels with age may impact cellular senescence and the overall tumor microenvironment.
  
- **Neurodegenerative Diseases**: While not directly proven, lncRNAs are increasingly recognized for their roles in neural regulation, which may implicate FAM83A-AS1 in age-related neural degeneration.

### 3. Drug Interactions

Currently, there is limited direct information on specific drugs targeting FAM83A-AS1. However, its involvement in cancer pathways can imply interaction with various cancer therapeutics including:

- **Chemotherapeutic agents**: Since FAM83A-AS1 is associated with cancer, treatments that target the pathways involving oncogenes and tumor suppressor genes may indirectly impact the function or expression of FAM83A-AS1.

- **Pathway inhibitors**: Drugs targeting signaling pathways (e.g., MAPK, PI3K/AKT) may affect FAM83A-AS1's role in cancer progression.

### 4. Pathways and Biological Processes

FAM83A-AS1 is involved in several critical biological processes and pathways:

- **Cell Proliferation**: It may play a role in regulating cell cycle progression and proliferation, influencing tumor growth.

- **Signal Transduction**: The gene is associated with multiple signaling pathways, particularly those related to cancer development, including the RAS pathway, which is crucial for transducing growth signals.

- **Gene Expression Regulation**: FAM83A-AS1 likely functions as a regulator of gene expression, impacting downstream genes involved in cancer and possibly other cellular functions.

- **Epigenetic Modification**: Long non-coding RNAs like FAM83A-AS1 often interact with chromatin-modifying complexes and play a role in epigenetic regulation.

In summary, FAM83A-AS1 is a relevant gene in the context of oncogenesis, aging, and potentially age-related diseases. Its interactions with other genes and pathways strengthen its importance in biological processes that require further research for deeper understanding.