**PSMG3-AS1 Gene Overview**

The PSMG3-AS1 gene is located on chromosome 21 and is categorized as a non-coding RNA gene, potentially characterized as an antisense RNA associated with the PSMG3 (Proteasome Assembly Chaperone 3) gene. Given the description as a “dubious CDS prediction,” the biological function and implications of PSMG3-AS1 remain somewhat uncertain and are under investigation.

### 1. Associated Genes

While specific direct associations of PSMG3-AS1 with other genes may not be prominently documented in the literature, its proximity to the PSMG3 gene suggests a potential regulatory relationship, as non-coding RNAs often have roles in the regulation of adjacent gene expression. Additional genes in proximity or within the same genomic neighborhood may also show some association but require experimental validation.

### 2. Aging and Age-Related Diseases

Currently, there is limited specific information linking PSMG3-AS1 directly to aging or age-related diseases. Non-coding RNAs, including long non-coding RNAs (lncRNAs) such as PSMG3-AS1, have been implicated in various cellular processes that can influence aging. However, the precise involvement of PSMG3-AS1 in these processes or diseases is not well characterized and will likely require further research to elucidate any potential associations.

### 3. Drug Interactions

As of my last knowledge update in October 2023, there are no specific drugs or drug classes that have been widely documented to interact with the PSMG3-AS1 gene. Due to the non-coding nature of the gene, direct pharmacological interactions are less common compared to protein-coding genes. However, compounds that modulate RNA expression or signaling pathways where PSMG3-AS1 might play a role could potentially influence its activity, although specific interactions remain to be explored.

### 4. Pathways and Biological Processes

Given the non-coding RNA status of PSMG3-AS1, clear functional annotation regarding specific pathways may be sparse. However, non-coding RNAs are generally involved in diverse biological processes, including:

- **Gene Regulation:** As an antisense RNA, PSMG3-AS1 could potentially play a role in regulating gene expression, particularly of the nearby PSMG3 gene.
- **Cellular Growth and Differentiation:** Many non-coding RNAs are involved in pathways associated with cellular proliferation and differentiation, which may indirectly link to processes affected by PSMG3-AS1.
- **Stress Responses:** Non-coding RNAs are often implicated in responses to cellular stress and could play roles in metabolic regulation, although specific pathways for PSMG3-AS1 are not well defined.

### Conclusion

While PSMG3-AS1 is recognized as a non-coding RNA gene, much about its functional implications, interactions, and specific roles in aging or disease remains uncertain and in need of further investigation. Its involvement with the PSMG3 gene indicates a potential regulatory role, though more detailed research is essential to clarify its biological significance.