### Overview of ATP1B3-AS1 Gene

**Gene Symbol**: ATP1B3-AS1  
**Location**: This gene is situated on chromosome 1, and it is classified as a long non-coding RNA (lncRNA), which means it does not code for a protein but is involved in the regulation of gene expression and other biological processes.

ATP1B3-AS1 is an antisense RNA associated with the ATP1B3 gene, which encodes the beta-3 subunit of the sodium/potassium ATPase enzyme. This enzyme is crucial for maintaining the electrochemical gradients across the plasma membranes of cells, playing vital roles in various physiological processes such as neuronal signaling and muscle contraction.

### 1. Associated Genes
ATP1B3-AS1 is predominantly associated with the following gene:

- **ATP1B3**: The primary associated gene, which it regulates. ATP1B3 encodes the beta-3 subunit of the Na+/K+ ATPase enzyme.

Other association information may vary, and novel findings on associations involving other genes linked to the function or regulation of ATP1B3-AS1 may not be extensively characterized in the literature.

### 2. Aging and Age-Related Diseases
Research linking ATP1B3-AS1 to aging and age-related diseases is still emerging. However, the underlying mechanism in maintaining ionic homeostasis through the Na+/K+ ATPase system is critical for cellular function, particularly in neurodegenerative diseases, cardiovascular diseases, and other conditions associated with aging. Dysregulation of sodium-potassium ATPase activity has been observed in age-related diseases, suggesting a potential indirect role for ATP1B3-AS1 in these processes through modulation of ATP1B3 expression or activity.

### 3. Drug Interactions
Currently, there are no specific drugs directly known to interact with the ATP1B3-AS1 gene itself, as it is a long non-coding RNA. However, drugs that affect sodium/potassium ATPase activity might indirectly influence the regulatory roles of ATP1B3-AS1.

Some general classes of drugs potentially interacting include:

- **Cardiac Glycosides**: Such as digoxin, which inhibit Na+/K+ ATPase and might influence expression levels of related genes, including those involved in signaling pathways where ATP1B3-AS1 is implicated.

### 4. Pathways and Biological Processes
ATP1B3-AS1 is involved in several biological processes and pathways:

- **Ion Transport**: Regulates sodium and potassium ion gradients across cell membranes.
- **Cell Signaling**: Influences various signaling pathways, particularly neuronal signaling pathways due to ATP1B3’s expression in neuronal cells.
- **Homeostasis**: Plays a crucial role in maintaining cellular homeostasis, which is vital for normal cellular functions.

**Pathways**: While specific pathways for ATP1B3-AS1 may not be extensively cataloged, it can affect downstream signaling pathways related to sodium/potassium homeostasis and potential regulatory networks implicated in cellular stress responses.

### Conclusion
ATP1B3-AS1 is a lncRNA linked with the ATP1B3 gene, playing a significant role in modulating the expression of this critical enzyme subunit and impacting cellular processes related to ion transport and cellular homeostasis. The gene may also correlate with aging and the pathophysiology of age-related diseases, although further studies are necessary to elucidate these relationships fully. Drug interactions remain primarily indirect, and its functions in various pathways highlight the importance of non-coding RNAs in gene regulation and cellular health.