### CDH17 Gene Overview

**Gene Symbol:** CDH17  
**Gene Description:** The CDH17 gene encodes a member of the cadherin superfamily, which comprises calcium-dependent glycoproteins instrumental in cell adhesion. Unlike typical cadherins, the protein lacks a cytoplasmic domain, containing instead seven extracellular cadherin-like domains and a transmembrane region. Predominantly expressed in the gastrointestinal tract and pancreatic ducts, it operates as a proton-dependent peptide transporter, underscoring its role in nutrient absorption and homeostasis.

### Associated Genes

While the NCBI and UniProt summaries do not mention specific associated genes, cadherins often function in complex networks of cell adhesion proteins. Therefore, related cadherin genes (e.g., **CDH1**, **CDH2**, and **CDH5**) or genes involved in similar signaling pathways (such as **BETA-CATENIN** and **ADHERENS JUNCTIONS** related genes) may demonstrate some functional interaction or association.

### Aging and Age-Related Diseases

1. **Aging:** Research indicates that the expression and function of CDH17 could be influenced by the aging process, especially in the context of gastrointestinal morphology and function. Changes in peptide transport efficiency may be noted in older populations, which could reflect altered nutrient absorption capabilities as one ages.
   
2. **Age-related Diseases:** As CDH17 is involved in intestinal health, it may be associated with age-related gastrointestinal disorders, such as atrophic gastritis or gastroesophageal reflux disease (GERD). The degeneration in the functionality of gastrointestinal transport systems may correlate with age-related changes in the anatomy and histology of the GI tract.

### Drug Interactions

There is limited direct information available regarding specific drug interactions with CDH17. However, because this gene plays a significant role in the absorption of peptide-based drugs, any medication designed to be absorbed through peptide transport mechanisms (e.g., some peptide hormones, insulin analogs, or certain antidiabetic drugs) could indirectly relate to CDH17 activity.

### Pathways and Biological Processes

CDH17 is implicated in:

1. **Cell Adhesion:** Contributing to cell-cell adhesion processes critical in maintaining tissue integrity and function in the gastrointestinal tract and pancreas.
2. **Intestinal Transport:** Participating in the transport of peptides across the intestinal epithelium, indicating its role in nutrient absorption.
3. **Morphological Organization:** Potentially influencing the structural organization within liver and intestinal tissues, which could affect organ morphology and function.

**Biological Pathways:**  
While specific pathways may not be extensively detailed, CDH17 can be connected to general pathways related to cell adhesion and junction formation, as well as metabolic pathways concerning nutrient absorption and transport.

### Summary

The CDH17 gene encodes an important protein in the gastrointestinal system, influencing both cell adhesion and nutrient transport. Its role may extend to implications in aging and age-related diseases, although specific associations require further research. The absence of a cytoplasmic domain, alongside a transmembrane region characterized by cadherin-like domains, highlights its functional uniqueness in the cadherin family. Further studies could elucidate the broader spectrum of this gene's physiological relevance and possible interactions with drug therapies.