The MTOR-AS1 gene (MTOR Antisense RNA 1) is a non-coding RNA gene that plays a significant role in the regulation of various cellular processes through its interaction with the MTOR (mechanistic target of rapamycin) pathway. Here’s a detailed overview based on your request:

### 1. Associated Genes
While specific genes associated with MTOR-AS1 might not be explicitly detailed in all sources, it is important to note its functional relationship with the **MTOR** gene, as MTOR-AS1 is an antisense RNA to the MTOR gene itself. Additionally, due to its role in the regulation of the MTOR signaling pathway, MTOR-AS1 may indirectly associate with genes involved in:
- **AKT (Protein Kinase B)**: Plays a role in the PI3K-AKT signaling pathway that is closely intertwined with the MTOR pathway.
- **RAPTOR (Regulatory-associated protein of mTOR)**: Part of the mTOR complex that is critical for its function.
- **S6K1 (Ribosomal protein S6 kinase 1)**: Involved in protein synthesis and cell growth mediated by mTOR signaling.
- **ULK1 (Unc-51 like autophagy activating kinase 1)**: Involved in autophagy regulation downstream of mTOR.

### 2. Aging and Age-related Diseases
MTOR-AS1, through its regulation of the MTOR pathway, is implicated in various processes related to aging and age-related diseases. The MTOR pathway is known to affect:
- **Cellular senescence**: It plays a critical role in the life span of cells by managing cell growth and proliferation.
- **Metabolic syndrome**: Dysregulation in this pathway can lead to obesity and type 2 diabetes, which are commonly seen in older populations.
- **Neurodegenerative diseases**: Increased mTOR signaling has been associated with diseases like Alzheimer's, where protein aggregation and cellular stress are prevalent.
- **Cancer**: Age is a significant risk factor for many types of cancer, and the MTOR pathway is frequently activated in tumors, leading to enhanced growth and survival.

### 3. Drug Interactions
While MTOR-AS1 is a non-coding RNA and does not have a direct pharmacological target, it is associated with drugs that target the mTOR signaling pathway. These include:
- **Rapamycin (Sirolimus)**: An mTOR inhibitor that is commonly used in transplant medicine and research related to aging.
- **Everolimus**: Another mTOR inhibitor that is used to inhibit tumor growth and has applications in immunology.
- **Temsirolimus**: A treatment for renal cell carcinoma, which also targets mTOR.

### 4. Pathways and Biological Processes
MTOR-AS1 is chiefly involved in:
- **Regulation of mTOR signaling pathways**: Its expression and regulatory functions help modulate mTOR activity, influencing cell growth and metabolism.
- **Cellular metabolism and growth**: Participates in the regulation of anabolic pathways and nutrient sensing.
- **Autophagy**: Related to cellular recycling processes, where it has roles in the regulation of autophagy through mTOR signaling.
- **Response to stress**: It may be involved in the cellular response to various forms of stress, including nutritional deprivation and oxidative stress.

### Conclusion
The MTOR-AS1 gene is crucial in regulating the MTOR pathway, influencing various cellular processes linked to growth, metabolism, and aging. Through its interactions, it plays a part in aging mechanisms and the pathogenesis of age-related diseases, while it is also associated with several drugs that target mTOR signaling. Understanding the precise functions of MTOR-AS1 can shed light on its potential roles in health and disease, particularly in the context of aging.