### NUP210L Gene Overview

**Gene Symbol:** NUP210L  
**Gene Type:** Protein-coding gene  
**Chromosomal Location:** Human chromosome 1

NUP210L is a member of the NUP210 family known for its involvement in nuclear pore complex assembly and function. It is integral to Sertoli cell and spermatid development in the male reproductive system.

### 1. Associated Genes

NUP210L may be associated with several genes that also play roles in reproductive functions and cellular transport mechanisms. The following genes may be related:

- **NUP210:** The closely related NUP210 gene is involved in nuclear pore functions and could be a relevant comparative gene.
- **NUP93, NUP188, and NUP155:** These genes all belong to the nuclear pore complex and may have functional connections to NUP210L in nuclear transport functions.
- **DAZL (Deleted in Azoospermia-Like):** Involved in spermatogenesis, it may interact with pathways modulated by NUP210L.
- **SMPD1 (Sphingomyelin Phosphodiesterase 1):** Could be associated owing to its role in signaling pathways in Sertoli and germ cells.

### 2. Aging or Age-Related Diseases

Research regarding NUP210L specifically related to aging or age-related diseases is limited. However, any alterations in nuclear pore complex proteins like NUP210L could potentially affect cellular processes related to aging. Dysregulation of nuclear transport can contribute to cellular senescence and age-related diseases. More studies are needed to elucidate specific links between NUP210L and the aging process or diseases like cancer, which can involve changes in spermatogenesis.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes directly indicated as interacting with NUP210L. However, since it is a component of the nuclear pore complex, drugs targeting cellular transport mechanisms or certain oncological therapies may indirectly influence its expression or function, given that many such agents act on cellular signaling associated with nuclear transport.

### 4. Pathways and Biological Processes

NUP210L is primarily involved in the following biological processes:

- **Nuclear Transport:** As an integral component of the nuclear pore complex, NUP210L is critical for the facilitation of nuclear transport, regulating the movement of proteins and RNA between the nucleus and cytoplasm.
- **Development:** It plays a significant role in Sertoli cell development and spermatogenesis, contributing to male fertility.
- **Signal Transduction:** Participation in pathways associated with cellular signaling, particularly those affecting reproductive development and related hormonal signaling.

Overall, NUP210L is pivotal in maintaining the integrity and function of the nuclear pore complex and by extension, is important for normal development, particularly in male reproductive biology. Further research will be essential to fully understand the connections of this gene to aging, disease, and pharmacology.