### ENTPD8 Gene Overview

**Gene Symbol**: ENTPD8  
**Function**: The ENTPD8 gene encodes a member of the ecto-nucleotide triphosphate diphosphohydrolase (NTPDase) family. The protein is predicted to have guanosine diphosphatase and uridine diphosphatase activities, facilitating the hydrolysis of nucleotides such as ATP, ADP, UTP, and UDP while not acting on AMP. As a canalicular ectonucleoside NTPDase, it primarily relates to the hydrolysis of extracellular nucleotides, playing a crucial role in maintaining nucleotide homeostasis in the liver.

### 1. Associated Genes
The ENTPD8 gene might interact with other genes involved in nucleotide metabolism, cell signaling, and liver function, although specific gene relationships are not detailed in the provided summaries. However, it is important to note that in biological systems, genes such as those coding for ecto-5'-nucleotide triphosphate diphosphohydrolase (ENTPDase family members) and other enzymes involved in nucleotide metabolism may be related. Examples may include:
- **ENTPD1**: Engaged in similar ecto-nucleoside diphosphate activities.
- **ENTPD2**: Also involved in hydrolytic activities of nucleotides.
- Genes involved in ATP metabolism or purinergic signaling pathways.

### 2. Aging and Age-Related Diseases 
There are limited direct associations specified in the literature specific to the ENTPD8 gene and aging or age-related diseases. However, because ectonucleoside NTPDases play pivotal roles in cellular signaling and nucleotide metabolism, their dysregulation could hypothetically contribute to age-related processes such as:
- **Cellular senescence**: Changes in nucleotide concentrations may influence cellular aging and senescence pathways.
- **Metabolic disorders**: Since ENTPD8 is involved in metabolic processes in the liver, dysfunction could relate to age-associated metabolic syndromes.

### 3. Drug Interactions
As of my latest knowledge update in October 2023, specific drug interactions with the ENTPD8 gene are not well-documented. However, drugs that influence nucleotide metabolism or purinergic signaling, either by targeting ectonucleotidases or by modulation of ATP levels, could potentially interact with its functions. Some categories may include:
- **Nucleotide analogs**: Used in cancer or viral infections that may impact nucleotide metabolism.
- **Purinergic signaling inhibitors**: Potentially affecting pathway dynamics that involve ENTPD8.

### 4. Pathways and Biological Processes
The ENTPD8 gene is involved in several biological processes and metabolic pathways, including:
- **Nucleoside Diphosphate Catabolic Process**: Catabolism of nucleotide diphosphates to maintain nucleotide pool.
- **Nucleoside Monophosphate Biosynthetic Process**: Participates upstream in pathways converting diphosphates to monophosphates.
- **Nucleotide Metabolism**: Overall involvement in purinergic signaling pathways and metabolism of extracellular nucleotides.
- **Cellular Signaling**: Impacts signaling pathways through the regulation of nucleotide availability.

In conclusion, ENTPD8 serves a critical role in nucleoside metabolism, specifically in the hydrolysis of nucleotides in the liver, and while its implications in aging and drug interactions are limited, it is essential for overall cellular functions and metabolic homeostasis. Further research may elucidate more specific roles within age-related conditions and pharmacological contexts.