### COX6CP14 Gene Overview

**Gene Symbol:** COX6CP14  
**Official Name:** Cytochrome c oxidase assembly factor 14

The COX6CP14 gene is involved in the assembly and regulation of cytochrome c oxidase (complex IV of the mitochondrial electron transport chain), which is critical for ATP production through oxidative phosphorylation.

### Additional Gene Associations

While specific associations were not highlighted in the summaries provided, COX6CP14 may be linked with other genes involved in mitochondrial function and oxidative phosphorylation, including:

1. **COX1, COX2, COX3:** These are the core components of cytochrome c oxidase.
2. **COX6C:** This gene codes for a subunit of cytochrome c oxidase.
3. **NDUFAF1:** Involved in the assembly of electron transport chain complexes.
4. **SURF1:** Known for its role in cytochrome c oxidase assembly.

### Aging and Age-related Diseases

Involvement of COX6CP14 in aging and age-related diseases can be indirect, through its role in mitochondrial function and energy metabolism. Mitochondrial dysfunction has been implicated in various age-related pathologies, including:

- **Neurodegenerative Diseases:** Such as Alzheimer's and Parkinson's, potentially linked to impaired mitochondrial respiratory chain activity.
- **Metabolic Disorders:** Age-related declines in energy metabolism could involve dysregulation of nuclear-encoded mitochondrial genes such as COX6CP14.
- **Aging Process:** Mitochondrial dysfunction accumulates with age, contributing to cellular senescence.

### Drug Interactions

As of October 2023, specific drugs that directly interact with the COX6CP14 gene are not well-characterized. However, certain general classes of drugs that impact mitochondrial function could have indirect effects, including:

- **Mitochondrial-targeted antioxidants:** Such as MitoQ, which may mitigate oxidative stress related to mitochondrial dysfunction.
- **Statins:** These can affect mitochondrial function, though their primary target is cholesterol synthesis.

### Pathways and Biological Processes

COX6CP14 is involved in various critical biological pathways and processes, which include:

1. **Oxidative phosphorylation:** Central to ATP production in mitochondria.
2. **Mitochondrial respiratory chain assembly:** Specifically in the assembly of cytochrome c oxidase.
3. **Apoptosis Regulation:** Through its role in mitochondrial function and energy metabolism.
4. **Response to oxidative stress:** Given the role of cytochrome c oxidase in cellular respiration and reactive oxygen species (ROS) generation.

In summary, COX6CP14 is a vital gene for mitochondrial function and energy production, with implications for aging and various diseases, especially those with a mitochondrial component, though direct interactions and relationships may require further research.