### RABL2A Gene Overview

**Gene Symbol**: RABL2A  
**Gene Type**: Protein-coding  
**Chromosomal Location**: Located in a subtelomeric region, associated with an ancestral telomere fusion event.  
**Gene Family**: Member of the RAB gene family within the Ras GTPase superfamily.  

**Function**:
The RABL2A gene encodes a small GTPase protein involved in intracellular transport processes, particularly within sperm cells. It plays a crucial role in:
- Male fertility.
- Sperm intra-flagellar transport (IFT), which is vital for the proper assembly and function of the flagellum.
- Binding GTP-regulated effector proteins that are involved in the development and functioning of cilia.

### 1. Associated Genes
While specific associated genes are not explicitly mentioned in the summaries, RABL2A might have functional associations with:
- **RABL2B**: A closely related paralog in humans, sharing similar functions.
- **RAB Proteins**: Other members of the RAB gene family, which are involved in various trafficking pathways.
- Genes involved in cilia assembly and function, such as **IFT genes** (including IFT88, IFT140, and IFT20), which are critical for ciliary structure and motility.

### 2. Aging and Age-Related Diseases
The function and regulation of RABL2A may have implications for aging due to its roles in ciliary activity and sperm function. Disruptions in ciliary function have been linked to a variety of age-related conditions, particularly in contexts such as:
- **Ciliopathies**: Disorders stemming from ciliary dysfunction may develop with age.
- **Fertility Issues**: Age-related decline in male fertility could be linked to mutations or dysregulation in genes involved in sperm motility and transport.
- **Neurodegenerative Diseases**: Cilia have been linked to signaling pathways involved in neurodegeneration; therefore, indirect associations may exist.

### 3. Drug Interactions
As of the information available, no specific drugs or drug classes are directly associated with the RABL2A gene. However, potential research directions could include:
- Therapeutics targeting ciliary signaling pathways may indirectly affect the function of proteins and processes influenced by RABL2A.
- Drugs that modify GTPase activity or affect interactions of Rab proteins could be relevant in research contexts.

### 4. Pathways and Biological Processes
RABL2A is involved in several crucial biological processes and pathways, including:
- **Intraflagellar Transport (IFT)**: Essential for the assembly and maintenance of cilia and flagella.
- **GTPase Activity**: Regulates cellular signaling by cycling between GTP-bound and GDP-bound states; integral in various signaling pathways.
- **Cellular Location**: Functions in intracellular transport, particularly relevant in the transport of proteins necessary for sperm motility.
- **Cilia Function**: Important in the development of cilia and their associated signaling pathways, influencing processes such as cell signaling and sensing.

### Conclusion
RABL2A is a multifunctional gene integral to reproductive health and cellular transport mechanisms. Its role in ciliary function binds it to fundamental biological processes with implications for age-related physiology and potential therapeutic interventions in male infertility and ciliopathies. Further research may provide deeper insights into the pathophysiology related to aging and disease.