### TMEM8B Gene Overview

**Gene Symbol:** TMEM8B  
**Location:** Cell surface and plasma membrane  
**Function:** TMEM8B is involved in cell-matrix adhesion and may act as a regulator of the Epidermal Growth Factor Receptor (EGFR) pathway. It is characterized as a probable tumor suppressor that may play significant roles in cell growth, proliferation, and adhesion.

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### 1. Associated Genes

While the summaries provided do not list specific genes directly associated with TMEM8B, it is known to interact with various signaling pathways and molecules related to cell adhesion and growth. Some potentially relevant genes to study in association with TMEM8B could include:

- **EGFR:** As TMEM8B is implicated in the EGFR pathway, it is important to consider its relationship with this gene.
- **STAT3:** Involved in cell signaling pathways that regulate numerous cellular processes, including cell growth and apoptosis.
- **Integrin genes (e.g., ITGA and ITGB family members):** Given TMEM8B’s role in cell adhesion, integrins may play a role in its function.

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### 2. Aging and Age-Related Diseases

Research on TMEM8B specifically related to aging or age-related diseases remains limited. However, given its role in tumor suppression, cell proliferation, and matrix adhesion, it may play indirect roles in cancer, which is a significant age-related disease. Notably:

- **Tumor Suppression:** As a probable tumor suppressor, alterations in TMEM8B expression or function might influence cancer susceptibility and progression in older adults.
- **Cellular Senescence:** Any gene involved in proliferation may affect cellular senescence, contributing to age-related cellular dysfunction.

Further empirical research is needed to delineate explicit associations between TMEM8B and aging or age-related diseases.

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### 3. Drug Interactions

While specific drugs directly acting on TMEM8B are not well-documented, potential interactions with therapies targeting the EGFR pathway could be inferred, given TMEM8B’s involvement:

- **EGFR Inhibitors:** Drugs like Erlotinib, Gefitinib, and Osimertinib that inhibit EGFR signaling may indirectly interact with the function of TMEM8B, especially in the context of cancers where EGFR is dysregulated.

Investigating specific clinical trials or studies focusing on TMEM8B within the context of drug interactions would provide more relevant information on this matter.

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### 4. Pathways and Biological Processes

TMEM8B is involved in several key biological processes and pathways, including:

- **Cell Adhesion:** Contributing to how cells bind to the extracellular matrix, affecting structure and integrity of tissues.
- **EGFR Signaling Pathway:** Influencing downstream effects of EGFR stimulation, including proliferation, survival, and differentiation of cells.
- **Tumor Suppression Pathways:** Regulatory mechanisms controlling cell growth, division, and response to stress, which can be critical in cancer progression.

Additional studies on TMEM8B may reveal more insights into its specific pathways and associated biological processes.

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#### Conclusion

TMEM8B serves as an important gene within the cellular framework, with implications in adhesion, regulation of key signaling pathways, and potential roles in tumor suppression. Nevertheless, additional studies are required to understand fully its implications in aging, drug interactions, and specific associated genes.