### TENT4A Gene Overview

**Gene Symbol:** TENT4A  
**Ensembl ID:** ENSG00000148203  
**NCBI Gene ID:** 7610  
**Location:** Chromosome 3

The TENT4A gene encodes a protein primarily identified as a terminal nucleotidyltransferase. This enzyme plays a significant role in RNA metabolism, specifically in the post-transcriptional modification of mRNAs. The TENT4A protein is involved in polyadenylation, adding adenine nucleotides to the 3' ends of RNA molecules, which is essential for mRNA stabilization and protection from degradation.

### Additional Information:

1. **Associated Genes:**
   - TENT4A has been noted in association with various genes involved in RNA metabolism and cellular processes related to gene regulation. Some notable genes that may interact with or be functionally related to TENT4A include:
     - **TRF4**: Involved in poly(A) tail addition.
     - **EXOSC**: Part of the exosome complex involved in RNA degradation.
     - **PABPN1**: Poly(A) binding protein that stabilizes poly(A) RNA.

2. **Aging and Age-Related Diseases:**
   - While specific studies directly linking TENT4A to aging are limited, the role of RNA metabolism and mRNA stability is crucial in the context of cellular senescence and age-related degeneration. Disruption in RNA processing and stability is commonly observed in age-related diseases such as neurodegeneration and cancer. Moreover, genes involved in RNA quality control (including TENT4A) may have implications in age-related conditions like Alzheimer’s disease.

3. **Drugs or Drug Classes:**
   - There are no specific drugs or drug classes widely reported to interact explicitly with TENT4A. However, compounds that modulate RNA metabolism (like those interfering with RNA polymerases, nucleotidyltransferases, or polyadenylation processes) may indirectly affect TENT4A activity and pathways. It is essential to consult updated pharmacogenomic data as new research emerges.

4. **Pathways and Biological Processes:**
   - TENT4A is involved in several significant biological pathways, including:
     - **RNA polyadenylation**: Adding poly(A) tails to mRNA, crucial for mRNA stability and export from the nucleus.
     - **mRNA stabilization**: Protecting mRNA from degradation, which influences gene expression levels.
     - **mRNA processing**: Involvement in the maturation and quality control of RNA.
     - **Post-transcriptional regulation**: Contributing to the regulation of gene expression at the RNA level.
     - **DNA repair**: Functioning in pathways related to maintaining genomic stability, although its role here may be less direct.

### Conclusion

TENT4A is an integral component of cellular processes particularly related to RNA metabolism and stability, and while research is ongoing, its potential implications in aging and certain diseases make it a candidate of interest for future studies. Further investigation into associated genes, pathways, and drug interactions may provide deeper insights into its functional role.