### TBL1XR1 Gene Overview

The **TBL1XR1** gene (Transducin Beta-Like 1 X-Linked Related 1) encodes a protein that plays important roles in transcription regulation, particularly in the context of nuclear receptor signaling and gene expression modulation. 

#### Summary of Information:

1. **Associated Genes**:
   - Other genes closely associated with TBL1XR1 include:
     - **TBL1X**: As mentioned, TBL1X shares sequence similarity and functions similarly in the context of nuclear receptor interaction.
     - **NCOA3 (Nuclear Receptor Coactivator 3)**: A coactivator that interacts with nuclear receptors and may work functionally with TBL1XR1 in transcriptional activation.
     - **HDAC3 (Histone Deacetylase 3)**: Works in concert with TBL1XR1 as the latter is part of deacetylase complexes.
     - **AKAP9 (A-kinase anchor protein 9)**: Known to interact with various signaling complexes and potentially with TBL1XR1.
     - Other genes include those involved in the components of the proteasome complex, as TBL1XR1 is implicated in ubiquitin-proteasome activity.

2. **Aging and Age-Related Diseases**:
   - While specific studies directly linking TBL1XR1 to aging are limited, the role of TBL1XR1 in transcription regulation may suggest potential implications in age-related processes such as cellular senescence and the efficiency of DNA damage repair mechanisms.
   - Given the association of mutations in TBL1XR1 with autism and intellectual disability, there may also be indirect implications regarding cognitive decline and neurodevelopmental aspects that become more relevant with aging.

3. **Drug Interactions**:
   - Currently, specific drugs directly targeting TBL1XR1 are not well-established in the literature. However, drug classes that may interact through the modulation of nuclear receptor pathways or histone deacetylation processes may indirectly influence its activity. These could include:
     - **Histone Deacetylase Inhibitors (HDACi)**: Used in cancer therapy and other conditions, these drugs can potentially affect the pathways regulated by TBL1XR1 and associated complexes.
     - **Nuclear Receptor Agonists/Antagonists**: These may influence the activity of TBL1XR1 by altering the function of nuclear receptors it associates with.

4. **Pathways and Biological Processes**:
   - TBL1XR1 is involved in several key biological pathways and processes:
     - **Transcription Regulation**: Integral in modulating the transcriptional activity of nuclear receptors.
     - **Proteasomal Degradation**: It plays a role in recruiting the 19S proteasome complex, thereby regulating the stability of transcriptional machinery components.
     - **Signal Transduction Pathways**: Participates in various signal transduction pathways that involve nuclear receptors.
     - **Ubiquitin-Proteasome System**: Essential for the ubiquitin-mediated degradation of proteins, which includes factors necessary for transcription and signal transduction.

Overall, TBL1XR1 is an important gene involved in transcriptional regulation, with mutations impacting neurological conditions and possibly linking to various biological pathways related to cellular signaling and proteostasis.