### NFYA Gene Overview

**Gene Symbol:** NFYA  
**Location:** Chromosome 6 (Human)

**Function:**
The NFYA gene encodes a protein that is a subunit of the NF-Y transcription factor complex, which is pivotal in binding to CCAAT motifs in promoter regions of various genes. NF-Y consists of three subunits—NF-YA, NF-YB, and NF-YC—forming a heterotrimeric complex. The NF-YA subunit is primarily responsible for recognizing specific DNA sequences, making it crucial for transcriptional regulation. NF-Y has roles as both an activator and a repressor depending on its interactions with other cofactors, allowing it to modulate gene expression in various biological contexts.

### Additional Information:

1. **Associated Genes:**
   - NF-YB (NFYB)
   - NF-YC (NFYC)
   - BMAL1 (related to circadian rhythm)
   - Other target genes influenced by NF-YA may include those involved in cell cycle regulation, apoptosis, and stress responses. Specific lists are often context-dependent and can vary based on experimental conditions.

2. **Aging and Age-related Diseases:**
   - **Cell Proliferation and Senescence:** NF-YA is involved in the regulation of genes associated with cell proliferation. Dysregulation of NF-YA has been linked to cellular senescence and age-related decline in tissue function.
   - **Age-related Diseases:** The NF-Y complex is implicated in disorders such as cancer, where aberrant expression of NF-Y subunits, including NFYA, can contribute to tumorigenesis. Additionally, NF-YA's role in regulating the circadian clock through BMAL1 may influence age-related circadian rhythm disorders.

3. **Drug Interactions:**
   - While there are no specific drugs that target NFYA directly, it can be seen as a potential target for therapeutic interventions in various conditions where NF-Y dysregulation is implicated, such as cancer. Research into small molecules or compounds that can modulate NF-Y activity or expression indirectly could provide avenues for treatment.

4. **Pathways and Biological Processes:**
   - **Gene Expression Regulation:** NF-Y participates in transcriptional regulation by binding specific DNA sequences.
   - **Circadian Rhythm:** NF-YA positively regulates BMAL1, a core component of the circadian clock, influencing processes governed by circadian rhythms.
   - **Cell Cycle Regulation:** NF-YA is involved in the transcription of genes important for cell cycle progression.
   - **Cellular Response to Stress:** NF-Y complex is implicated in stress response pathways, including heat shock responses and hypoxia.
   - **Apoptosis:** Certain target genes regulated by NF-YA can be involved in apoptotic signaling pathways.

### Summary
NFYA is a crucial transcription factor with pivotal roles in various cellular processes, including the regulation of the cell cycle, stress responses, and circadian rhythms. Its involvement in aging and age-related diseases, particularly through its connection to cellular senescence and tumorigenesis, underscores its potential as a therapeutic target. Understanding its regulatory networks and interactions with other genes remains essential for elucidating its full biological significance.