**HIRA Interacting Protein 3 (HIRIP3) Gene Overview**

**Gene Symbol:** HIRIP3

**Summary:**  
The HIRIP3 gene encodes a protein believed to interact with the HIRA protein, itself a transcriptional co-repressor involved in histone regulation. Given its role in chromatin function and histone metabolism, HIRIP3 may form part of a multiprotein complex that influences histone dynamics and chromatin remodeling pathways. Several alternative splicing events result in various isoforms of the HIRIP3 protein, each potentially having diverse functional roles.

### 1. Associated Genes:
While specific genes associated with HIRIP3 beyond HIRA and histones H2B and H3 aren't deeply elaborated in standard summaries, potential gene interactions within chromatin remodeling and histone metabolism could include genes involved in:
- HIRA itself (which HIRIP3 interacts with)
- Other HIRA-interacting proteins (HIRIPs)
- Genes involved in post-translational modifications of histones (e.g., histone methyltransferases like SETD1A, SETD2).

### 2. Aging and Age-related Diseases:
The role of HIRIP3 in chromatin function implies it may be implicated in processes related to aging and age-related diseases, potentially through the following mechanisms:
- **Chromatin Remodeling:** Given the importance of chromatin structure in gene expression regulation, alterations in HIRIP3 or its interactions may influence aging processes and cellular senescence.
- **Cancer:** Histone-modification pathways, which HIRIP3 is involved in, are often dysregulated in age-associated cancers. Though specific links are necessary for verification, overexpression of histone gene regulators may contribute to oncogenesis in an aging context.

### 3. Drug/Drug Classes Interactions:
As of the current literature, specific small molecules or drug classes directly interacting with HIRIP3 have not been firmly established. However, drugs targeting chromatin remodeling complexes, histone deacetylases (HDACs), or histone-modifying enzymes could potentially affect HIRIP3 due to its role in histone metabolism. Research is needed to elucidate any direct interactions with pharmacological compounds.

### 4. Pathways and Biological Processes:
HIRIP3 is involved in several essential biological pathways and processes:
- **Histone Metabolism:** Contributing to the assembly and disassembly of nucleosomes, thereby regulating gene expression.
- **Chromatin Remodeling:** Influencing the accessibility of DNA for transcription factors and RNA polymerase.
- **Nuclear Processes:** Possible involvement in gene silencing and transcriptional regulation through histone modifications.

Overall, future research might reveal more precise interactions involving HIRIP3, especially concerning age-related changes and therapeutic implications. Studies relating to its specific role in cellular aging and the development of age-associated diseases will be especially valuable for understanding its significance in health and disease.