### CD83 Gene Overview

**Gene Symbol**: CD83

**Gene Description**: The CD83 gene encodes a single-pass type I membrane protein classified as a member of the immunoglobulin superfamily of receptors. This protein is predominantly expressed on the surface of activated dendritic cells, B cells, and T lymphocytes. CD83 is important for the regulation of antigen presentation and plays a significant role in the interactions that occur following lymphocyte activation, which are crucial for the adaptive immune response.

#### 1. Associated Genes
CD83 is associated with several other genes involved in immune function and signaling pathways, including:
- **CD80 and CD86**: Costimulatory molecules that enhance T-cell activation.
- **CD40**: A molecule involved in B-cell activation and dendritic cell maturation.
- **IL-10 and IL-12**: Cytokines involved in regulating immune responses.
- **MHC Class II genes (e.g., HLA-DRA, HLA-DRB1)**: Genes critical for the presentation of antigens to T cells.

#### 2. Aging and Age-Related Diseases
While specific studies directly linking CD83 to aging and age-related diseases are somewhat limited, there is evidence suggesting that CD83 may play a role in:
- **Immunosenescence**: The gradual deterioration of the immune system associated with aging. Changes in CD83 expression can affect the activation and function of dendritic cells, which may influence the age-related decline in immune responses.
- **Neurodegenerative Diseases**: CD83 has been implicated in inflammatory responses, which may have a connection to diseases such as Alzheimer’s. Increased CD83 expression has been observed in the brains of Alzheimer's patients, suggesting a role in neuroinflammation.
- **Autoimmune Disorders**: Dysregulation of CD83 expression may contribute to autoimmunity, conditions that often have age-related onset.

#### 3. Drug Interactions
Currently, there are no specific drugs that are widely known to directly interact with the CD83 protein itself. However, immunomodulatory drugs may indirectly influence CD83 expression or function, such as:
- **Monoclonal Antibodies**: Some therapies designed to modulate immune responses may affect CD83 signaling.
- **Immunosuppressants** (e.g., corticosteroids, calcineurin inhibitors): These drugs may alter the immune landscape and affect CD83 expression, particularly as CD83 is involved in immune cell activation.

#### 4. Pathways and Biological Processes
CD83 is involved in several significant biological processes and pathways, including:
- **Antigen Presentation**: CD83 is critical for the proper functioning of dendritic cells and their ability to present antigens to T cells.
- **T Cell Activation**: CD83’s expression is upregulated during T cell activation, and it helps facilitate interactions between T cells and antigen-presenting cells.
- **Cytokine Production**: It influences the secretion of various cytokines by immune cells, shaping the overall immune response.
- **Immune Regulation**: CD83 can act as a regulatory molecule influencing the maturation of dendritic cells and modulating adaptive immune responses.

In summary, CD83 is a key player in immune regulation, particularly in the context of dendritic cell function and T cell activation. Its involvement in various pathways highlights its significance in both normal immune processes and potential implications in aging and immunological disorders.