### ENTPD6 Gene Overview

**Gene Symbol:** ENTPD6  
**Gene Type:** Protein-coding  
**Chromosomal Location:** Human chromosome 18q12.3  
**Function:** The ENTPD6 gene encodes a member of the E-type nucleotidases, which are enzymes that hydrolyze nucleotides, playing critical roles in nucleotide metabolism and signaling.

### 1. Associated Genes
ENTPD6 may have associations with several genes related to nucleotide metabolism and signaling pathways. Some of these genes include:

- **ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)**: Another ecto-nucleotide triphosphate diphosphohydrolase involved in controlling extracellular nucleotide levels.
- **CD39 (ENTPD1)**: Known for hydrolyzing ATP and ADP, it is integral in immune regulation and also mediates catabolism of extracellular nucleotides.
- **NPTN (nucleoside triphosphate diphosphohydrolase)**: Related in function, as both involve nucleotide metabolism.

### 2. Aging and Age-Related Diseases
Although specific studies directly linking ENTPD6 to aging or age-related diseases may be limited, alterations in nucleotide metabolism have been implicated in:

- **Immune system modulation** during aging: As ENTPD6 regulates nucleotide levels, it could influence immune responses, which tend to decline with age.
- **Neurodegenerative diseases**: Dysregulation in nucleotide metabolism can affect ATP levels and energy homeostasis, factors closely associated with diseases like Alzheimer’s and Parkinson's.

### 3. Drug Interactions
As of now, there are few specific drugs directly known to interact with ENTPD6. However, drugs that target nucleotide metabolism or those that modulate immune responses could potentially impact the activity of ENTPD6. For instance:

- **Anticoagulants**: Given the role of ATP and ADP in platelet function, drugs like clopidogrel, which impact ADP signaling, might indirectly affect the activity of nucleotide-digesting enzymes like ENTPD6.
- **Immunomodulators:** Drugs like adenosine receptor agonists may influence pathways involving extracellular nucleotide metabolism, which can be indirectly related to ENTPD6 function.

### 4. Pathways and Biological Processes
ENTPD6 is involved in several key biological processes and pathways:

- **Nucleotide Metabolism**: It plays a crucial role in the hydrolysis of nucleoside triphosphates and diphosphates, regulating extracellular nucleotide levels.
- **Purine Metabolism**: Although primarily known for hydrolyzing nucleoside diphosphates, its activity can affect pathways implicated in purine metabolism.
- **Cellular Signaling**: Interacting with ATP and ADP can influence associated signaling pathways, such as those involving purinergic receptors.
- **Glycosylation Processes**: The membrane-bound form of ENTPD6 might participate in glycosylation reactions in the Golgi apparatus, affecting protein modification and trafficking.

### Summary
The ENTPD6 gene is essential for maintaining nucleotide homeostasis and influences critical biological processes. Its associations with other nucleotidases, potential implications in aging, and involvement in nucleotide metabolism underline its importance in cellular functions and possibly age-related health considerations. Further research may elucidate more specific drug interactions and precise roles in pathophysiological conditions.