The gene **EPHA5-AS1** is a long non-coding RNA (lncRNA) associated with the EPHA5 gene, which encodes a member of the ephrin receptor family. This family of receptors plays critical roles in various biological processes, particularly in development, neural patterning, and angiogenesis.

### 1. Associated Genes
While specific associations are primarily derived from literature and databases, EPHA5-AS1 may be functionally related to other genes involved in neuronal signaling and development due to its association with the EPHA5 gene. Some genes that are often mentioned in relation to EPHA5 include:
- **EPHA5**: The primary associated gene that EPHA5-AS1 is known to regulate.
- **Ephrin-A1 (EFNA1)**: A ligand that interacts with EPHA5 and influences developmental processes.
- **Other Eph receptors (e.g., EPHA4)**: As members of the same receptor family, they may exhibit overlapping functions and regulatory networks.

### 2. Aging and Age-Related Diseases
Though direct research into EPHA5-AS1 in the context of aging or age-related diseases is scarce, Eph receptors, including EPHA5, have been implicated in several age-related processes and diseases. Examples include:
- **Neurodegeneration**: Alterations in the Eph/ephrin signaling pathway have been associated with neurodegenerative diseases.
- **Cancer**: Important in tumor angiogenesis, and aberrant Eph signaling has been linked to various cancers, which are notably more prevalent with advancing age.

EPHA5-AS1's regulatory role could suggest it plays a part in these processes, though specific studies are warranted to elucidate its impact on aging.

### 3. Drug Interactions
Currently, there is limited information available directly linking drugs or drug classes to EPHA5-AS1 specifically. However, drugs that target the Eph/ephrin pathway are of interest:
- **Ephrin receptor inhibitors**: These are being studied for their role in cancer treatment, which may indirectly affect the expression or function of EPHA5-AS1.
- **Tyrosine kinase inhibitors (TKIs)**: As EPHA5 is a receptor-type tyrosine kinase (RTK), some TKIs may have downstream effects involving EPHA5 signaling.

No specific drugs have been documented to target EPHA5-AS1 directly at this time.

### 4. Pathways and Biological Processes
EPHA5-AS1 is known to be involved in various biological processes and pathways, primarily through its relationship with EPHA5. These include:
- **Neural Development**: EPHA5 participates in nervous system development, particularly in axon guidance.
- **Cell Migration and Adhesion**: The ephrin signaling pathway influences cell movement and tissue architecture.
- **Angiogenesis**: Eph receptors are crucial for vascular development and stabilization.
- **Signaling Pathways**: It may play a role in signaling pathways such as the MAPK/ERK and Rho GTPase pathways, which are involved in growth factor signaling and cytoskeletal organization.

In summary, while EPHA5-AS1's specific functions and associations require further research, its regulation of the EPHA5 gene links it to critical developmental and pathological processes. Exploration into its roles in aging and drug interactions is still in nascent stages, indicating a potential area for future investigation.