### NUP43 Gene Overview

**Gene Symbol**: NUP43  
**Location**: This gene is located on chromosome 10 in humans.

**Description**:  
The NUP43 gene encodes a protein that is a component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The nuclear pore complex is essential for nucleocytoplasmic transport, allowing for the regulated passage of molecules between the nucleus and cytoplasm. The Nup107-160 subcomplex is crucial for assembling a functional NPC and ensuring proper kinetochore microtubule attachment, mitotic progression, and chromosome segregation during cell division.

### 1. Associated Genes
While specific genes directly associated with NUP43 may not be explicitly mentioned in the provided summaries, the following are known to interact or function in pathways related to NPC and mitosis:

- **NUP37**: Another nucleoporins member that collaborates with NUP43 in the assembly of the nuclear pore.
- **NUP107**: A core member of the Nup107-160 complex, which suggests functional interactions within the NPC.
- **NDC1**: A nucleoporin that plays a role in the assembly of the nuclear pore complex.
- **KIF2A**: Involved in the regulation of microtubule dynamics and has a direct impact on chromosome segregation.

### 2. Aging and Age-Related Diseases
The NUP43 gene, as part of the nuclear pore complex, has implications in cellular aging and age-related diseases. Some known associations include:

- **Cellular Senescence**: Altered nuclear pore composition and function are observed in senescent cells. Anomalies in nucleocytoplasmic transport have been linked to the aging process.
- **Cancer**: Dysregulation of components of the nuclear pore complex, including NUP43, has been implicated in tumorigenesis, suggesting that alterations in its function may contribute to cancer progression.
- **Neurodegenerative Diseases**: Changes in nucleocytoplasmic transport efficiency can contribute to neurodegenerative conditions, as proteins may not be effectively shuttled between the nucleus and cytoplasm. Research indicates that nucleoporins, including NUP43, may play roles in diseases like Alzheimer's and Huntington's.

### 3. Drug Interactions 
Currently, there is no specific information regarding drugs or drug classes that directly interact with the NUP43 gene or its protein product. However, as NUP43 is part of critical cellular processes, frameworks targeting the nuclear pore complex for drug delivery systems or cancer therapies may indirectly affect its function.

### 4. Pathways and Biological Processes
NUP43 is involved in several critical biological processes and pathways, including:

- **Nucleocytoplasmic Transport**: Functions primarily as part of the nuclear pore complex, facilitating the transport of proteins and RNA.
- **Cell Division**: Integral to mitotic processes, ensuring proper attachment of microtubules to kinetochores and timely chromosome segregation during cell division.
- **SPP1 (Signal Peptide Peptidase) Pathway**: Studies suggest involvement in pathways affecting immune responses and other cellular signaling.
- **Assembly of Nuclear Pore Complex**: NUP43 plays a role in the formation and maintenance of nuclear pores, vital for maintaining cellular homeostasis.

### Summary
NUP43 is an essential gene playing a critical role in nuclear pore complex assembly, mitosis, and cellular transport processes. Further research continues to elucidate its roles in aging and various disease contexts, providing a deeper understanding of its biological significance.