### EPHB2 Gene Overview
The EPHB2 gene encodes a member of the Eph receptor family, specifically categorized as an Eph tyrosine kinase receptor. It plays a significant role in numerous developmental processes and cellular interactions through its unique binding to ephrin-B family ligands.

### 1. Associated Genes
While the summaries provided do not specifically list associated genes, EPHB2 is known to interact with several other genes and pathways. Notable associations include:

- **EFNB1 and EFNB2**: These are the primary ligands that interact with EPHB2 to initiate bidirectional signaling.
- **ARHGEF15**: Identified as a downstream effector whose negative regulation on excitatory synapse formation is modulated by EPHB2 signaling.
- Other Eph receptors and ephrins, including **EPHA5, EPHB3** and **EPHB6**, which may play synergistic roles in cellular processes coordinated by EPHB2.

### 2. Aging and Age-related Diseases
Research indicates that EPHB2 has implications in aging, particularly concerning neuronal development and function:

- **Neurodegenerative Diseases**: Changes in EPHB2 signaling have been linked to the progression of neurodegenerative conditions such as Alzheimer's disease. Abnormalities in axon guidance and synaptic plasticity suggest a role for EPHB2 in age-related cognitive decline.
- **Cancer**: The association between EPHB2 and susceptibility to cancers (like prostate and brain cancers) may become significant with aging as cancer risk generally increases in older populations.
- **Platelet Activation and Coagulation**: Aging often affects hemostatic function, and disruptions in EPHB2 pathways could thus potentially contribute to age-related changes in clotting.

### 3. Drug Interactions
While specific drug interactions with the EPHB2 protein are not extensively characterized, potential drug targets related to this gene include:

- **Ephrin mimetics and EPHB2 inhibitors**: These could include small molecules that modulate Eph/ephrin interactions, particularly in the context of cancer and regenerative medicine.
- **Tyrosine Kinase Inhibitors**: As EPHB2 is a receptor tyrosine kinase, inhibitors targeting kinases could theoretically have effects on EPHB2 signaling pathways.

### 4. Pathways and Biological Processes
EPHB2 is involved in various critical biological processes and signaling pathways:

- **Neuronal Development**: It plays a crucial role in **axon guidance** and the maturation of synapses in the central nervous system.
- **Angiogenesis**: EPHB2 is involved in vascular development and the regulation of blood vessel formation.
- **Cell Adhesion and Movement**: EPHB2 signaling influences cell migration and adhesion, particularly important in developmental processes such as urethral and cloacal development.
- **Immune Regulation**: EPHB2 may have a regulatory role in immune cell interactions and platelet function, influencing blood coagulation pathways.

In summary, the EPHB2 gene has multifaceted roles extending beyond simple signaling to encompass critical developmental processes, particularly in neuronal guidance, cell adhesion, and potentially influencing age-related health conditions and diseases. Further research continues to elucidate its various interactions and implications in health and disease.