### NIFKP8 Gene Overview

**Gene Symbol**: NIFKP8  
**Description**: NIFKP8 (Nuclear Import Factor Karyopherin 8) encodes a protein that typically plays a role in the nuclear transport system, facilitating the import of proteins into the nucleus.

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### 1. Associated Genes
While specific interactions or associations outside the key literature are limited, NIFKP8 may interact with several other genes as part of its function within the nuclear transport machinery. Potentially associated genes based on known nuclear transport components could include:

- **KPNB1 (Karyopherin Beta 1)**: Involved in transporting proteins into the nucleus.
- **RAN (RAN Oncogene)**: A small GTPase critical for the directionality of nuclear transport.
- **NUTF2 (Nuclear Transport Factor 2)**: Partner in nuclear transport processes.
- **KPNC1 (Karyopherin Alpha 1)**: Participates in the nuclear import of proteins.

These potential associations are based on functional pathways typically regulated by karyopherins and nuclear transport factors.

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### 2. Age-Related Details
Currently, there is limited literature explicitly linking NIFKP8 to aging or age-related diseases. However, given its involvement in nuclear transport, it may indirectly influence cellular aging through roles in gene expression regulation, DNA repair, and maintaining genomic integrity. Any potential connection to age-related diseases might stem from disruptions in nuclear transport mechanisms or misregulation of gene expression linked to aging.

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### 3. Drug Interactions
As of the latest data until October 2023, specific drugs or drug classes known to interact with the NIFKP8 gene are not explicitly detailed in the available literature. However, it is reasonable to hypothesize that drugs targeting karyopherins or nuclear transport pathways may influence the function or regulation of NIFKP8. Drugs acting on the pathways governing cell cycle regulation or DNA repair might also indirectly impact NIFKP8 activity.

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### 4. Pathways and Biological Processes
NIFKP8 is involved in several critical biological processes and pathways, including:

- **Nuclear Import**: It plays a vital role in the import of proteins containing nuclear localization signals (NLS) into the nucleus.
- **Nuclear Transport**: Participates in the transport of macromolecules between the cytoplasm and nucleus.
- **RNA Processing**: May interact in pathways related to RNA export or processing given its role in nucleocytoplasmic transport.
- **Cell Cycle Regulation**: Implications in the regulation of the cell cycle may occur due to the role of nuclear transport in transcriptional regulation.

### Summary
Overall, the NIFKP8 gene is crucial for nuclear transport processes. Its broader implications regarding aging, drug interactions, and pathways reveal the complex functions it may serve within cellular biology. Additional research might clarify its specific roles in age-related phenomena and provide insights into therapeutic potentials for diseases linked to nuclear transport dysregulation.