### HAUS8 Gene Overview

**Gene Symbol:** HAUS8  
**Function:** The HAUS8 gene encodes a protein that is a component of the HAUS augmin-like complex. This protein is crucial for several cellular processes, including mitotic spindle assembly, maintenance of centrosome integrity, and the completion of cytokinesis. 

### Associated Genes
- **HAUS6:** Another component of the HAUS complex, involved in mitotic spindle assembly.
- **HAUS3:** Also part of the HAUS complex; plays a role in the same pathways as HAUS8.
- **HAUS4:** This gene encodes a protein that interacts with HAUS8 and is necessary for augmin function.
- **TUBG1:** While not immediately part of the HAUS complex, it is involved in microtubule organization and may indirectly interact with HAUS8's functions.

### Aging and Age-Related Diseases
There is limited specific data connecting HAUS8 directly to aging or age-related diseases. However, improper function or dysregulation of genes involved in mitotic spindle assembly and cell division—including HAUS8—may contribute to cellular senescence and genomic instability, which are associated with aging and age-related diseases like cancer. Potential roles in cancer due to their involvement in cell division may suggest an indirect association with age-related malignancies.

### Drug Interactions
Currently, there is no well-established drug specifically targeting HAUS8 or any known drug classes that interact directly with HAUS8. Research in the context of its role in cell division may suggest potential avenues for drug development, particularly in the context of cancer therapies aimed at mitotic fidelity and targeting mitotic spindle assembly. However, such connections remain largely hypothetical at this stage.

### Pathways and Biological Processes
HAUS8 is involved in several key pathways and biological processes, including:
- **Mitotic Spindle Assembly:** A critical process for accurate cell division and segregation of chromosomes.
- **Cytokinesis:** The final step in cell division, where the cytoplasm is divided to form two daughter cells.
- **Centrosome Integrity:** Maintenance of centrosome structure and function, which is important for microtubule organization.
- **Augmin Complex Function:** Contributing to the action of the augmin complex which promotes microtubule nucleation in the spindle.

Overall, the HAUS8 gene plays a significant role in ensuring proper mitotic processes, which are crucial for healthy cellular function and division. Further research may elucidate its implications in aging and disease states, expanding the understanding of its biological importance.