### SNORD115-33 Gene Overview

**Gene Symbol**: SNORD115-33  
**Type**: Small nucleolar RNA (snoRNA)  
**Location**: Chromosome 15, within the SNORD115 gene cluster, which contains multiple snoRNAs.

#### 1. Associated Genes:

SNORD115-33 is part of the SNORD115 gene cluster, which includes other snoRNA genes, notably:
- **SNORD115-1**
- **SNORD115-2**
- **SNORD115-3**
- **SNORD115-4**
- **SNORD115-5**  
These snoRNA genes are known to participate in the modification of ribosomal RNA (rRNA) and contribute to ribosome biogenesis and function.

While direct associations with other genes are not typically highlighted, the broader interplay of snoRNAs with ribosomal proteins and other RNA processing factors may indirectly involve various transcription and translation-related genes.

#### 2. Aging and Age-Related Diseases:

Research on the specific role of SNORD115-33 in aging or age-related diseases is limited. However, snoRNAs have been implicated in various cellular processes that are relevant to aging, including:
- **Regulation of ribosome biogenesis**: As organisms age, ribosomal function often declines, which can impact overall cellular function and contribute to age-related diseases.
- **Neurological Conditions**: Some studies suggest that the SNORD115 gene cluster may be associated with neurological disorders, including those related to abnormal developmental regulation, potentially impacting age-related cognitive decline.

#### 3. Drug Interactions:

As of now, there are no specific drugs or drug classes known to directly target SNORD115-33. However, because snoRNA functions can influence mRNA splicing and ribosome function, alterations in these pathways may indirectly affect how cells respond to certain drugs that target cell growth, cancer pathways, or other cellular functions.

#### 4. Pathways and Biological Processes:

SNORD115-33 is primarily involved in:
- **Ribosomal RNA (rRNA) modification**: It modifies precursor rRNA, which is essential for the production of mature rRNA components of ribosomes.
- **Ribosome biogenesis**: The functioning of snoRNAs like SNORD115-33 is crucial for the synthesis and processing of rRNA, a key process in cellular growth and function.
- **Nuclear processing of RNA**: It may also play a role in the broader context of RNA processing and modification within the nucleolus.

In summary, while SNORD115-33 primarily serves a role in RNA processing and ribosomal function, its specific involvement in aging and drug interactions is an area that may benefit from further research to elucidate its roles in health and disease contexts.