### CENPK Gene Overview

#### Gene Symbol:
- **CENPK**

#### Protein Summary:
CENPK is a component of the CENPA-CAD (CENPA-Centromere-Associated Domain) complex, which plays a critical role in centromere function. This gene is involved in the assembly of kinetochore proteins, which are essential for mitotic progression and the proper segregation of chromosomes during cell division. CENPK is thought to facilitate the incorporation of newly synthesized CENPA (Centromere Protein A) into centromeres through its interaction with the CENPA-NAC (CENPA-Nucleosome-Associated Complex). Additionally, CENPK collaborates with KNL1 to recruit the NDC80 complex to the outer kinetochore, an essential step for ensuring proper chromatid separation.

### 1. Associated Genes:
CENPK is associated with several other genes, especially those involved in the formation and functioning of the kinetochore and centromere. Some notable associated genes include:
- **CENPA** (Centromere Protein A)
- **CENPB** (Centromere Protein B)
- **KNL1** (Kinetochore Scaffold Protein 1)
- **NDC80** (NDC80 Complex Component)
- **BUB1** (BUB1 Mitotic Checkpoint Serine/Threonine Kinase)
- **SPC24** (Spindle Pole Component 24)

### 2. Aging and Age-Related Diseases:
Current research has not directly linked CENPK to aging or specific age-related diseases in a prominent manner. However, given its role in cell division and chromosome segregation, any dysfunction could hypothetically contribute to age-related pathologies, particularly those involving genomic instability, such as cancer. Further investigation into its expression and mutation in aged populations or age-related diseases may reveal more about its potential association with these health issues.

### 3. Drug Interactions:
As of the latest data, no specific drugs or drug classes are widely reported to interact directly with the CENPK gene/protein; however, given its role in the cell cycle, drugs that target mitotic processes, such as microtubule inhibitors (e.g., paclitaxel, vincristine), might indirectly affect the cellular functions where CENPK is involved. 

### 4. Pathways and Biological Processes:
CENPK is implicated in several key biological processes, including:
- **Cell Cycle Regulation**: Essential for proper progression through mitosis.
- **Chromosome Segregation**: Ensuring accurate distribution of chromosomes to daughter cells.
- **Kinetochore Assembly**: Critical for the function of the kinetochore during cell division.
- **Centromere Assembly**: Plays a role in the assembly and maintenance of the centromere structure.

CENPK is also part of pathways involving cellular responses to DNA damage and checkpoint signaling, which are crucial for maintaining genomic stability.

### Conclusion:
CENPK is fundamental to centromere function and chromosome segregation during cell division. Future research may uncover more detailed associations with aging and specific diseases, alongside potential therapeutic targets involving this gene.