### KDM5C Gene Overview

**Gene Symbol**: KDM5C  
**Location**: X chromosome  
**Function**: The KDM5C gene encodes a histone demethylase that modulates transcription and chromatin structure by specific demethylation of histone H3 at lysine 4 (H3K4). It is involved in regulating gene expression and maintaining transcriptional repressiveness for certain neuronal genes.

#### 1. Associated Genes 
While the summary predominantly focuses on KDM5C, it is important to note that KDM5C interacts with or is functionally related to several other genes and proteins, including:

- **REST** (RE1 Silencing Transcription Factor) - involved in neuronal repression.
- **HDAC1 and HDAC2** (Histone Deacetylases) - recruited to exert repressive functions.
- **CLOCK** and **BMAL1** - transcription factors that play a role in circadian rhythms and potentially influence KDM5C's activity on genes such as PER2.

#### 2. Aging and Age-Related Diseases
Recent studies have indicated that alterations in KDM5C activity may impact aging processes and contribute to age-related pathologies:

- **Cognitive Decline**: Mutations in KDM5C are associated with cognitive disabilities, primarily affecting learning and memory, suggesting that its regulatory role on neuronal genes can influence neural aging.
- **Cancer**: As a regulator of chromatin and transcription, KDM5C has also been implicated in the development of certain cancers, highlighting its potential role in the aging process through its effects on tumorigenesis.
- **Neurodevelopmental Disorders**: Abnormalities in KDM5C function are linked to conditions like intellectual disability, which can have longstanding effects into older age, emphasizing its relevance in neurodevelopment.

#### 3. Known Drug Interactions
As of the current reviews, direct pharmacological interactions specifically with KDM5C have not been extensively characterized. However, drugs influencing histone modifications or targeting HDACs or similar pathways may indirectly interact with KDM5C function. Some related drug classes may include:

- **Histone Deacetylase Inhibitors (HDACi)**: These can affect the recruitment and function related to KDM5C.
- **Epigenetic Modifiers**: Any agents that alter histone methylation might impact KDM5C activity indirectly.

#### 4. Pathways and Biological Processes
KDM5C is involved in several critical biological pathways including:

- **Histone Modification**: This gene is crucial in the histone code regulation, specifically modulating histone methylation states.
- **Transcriptional Regulation**: It plays a key role in repressing transcription at neuronal genes.
- **Neuronal Development**: Implicated in differentiation and maturation processes of neurons.
- **Circadian Rhythm Regulation**: It affects the expression of genes involved in circadian clocks, highlighting its broader implications in homeostatic regulation.

Overall, KDM5C stands as a critical player in chromatin dynamics, transcriptional regulation, cognition, and potentially, in processes associated with aging and neurodevelopmental health.