### ZNF91 Gene Overview

**Gene Symbol:** ZNF91  
**Gene Type:** Protein-coding  
**Chromosomal Location:** Human chromosome 19p12  

### Protein Summary
The ZNF91 gene encodes a transcription factor that plays a crucial role in repressing the expression of SINE-VNTR-Alu (SVA) retrotransposons. ZNF91 specifically recognizes and binds to SVA sequences, inhibiting their expression by recruiting a repressive complex that includes TRIM28/KAP1. There is also evidence suggesting that ZNF91 may bind to the promoter region of the FCGR2B gene, potentially repressing its expression, although further research is needed to confirm this in vivo.

### 1. Associated Genes
ZNF91 is primarily associated with the following genes:
- **TRIM28 (also known as KAP1)**: A core component of the repressive complex that ZNF91 recruits for regulating retrotransposons.
- **FCGR2B**: The gene that encodes Fc receptor for immunoglobulin G, which ZNF91 may influence as a potential target.

### 2. Aging and Age-Related Diseases
While specific studies focusing directly on ZNF91 in the context of aging and age-related diseases are limited, its role in regulating retrotransposon activity may contribute to genomic stability, which is often compromised during aging. Uncontrolled retrotransposon activity has been implicated in various age-related conditions, including neurodegenerative diseases and certain cancer types. The potential link between ZNF91 and cellular senescence through its involvement in transcriptional repression also emphasizes its relevance in aging research.

### 3. Drug Interactions
As of the latest data, there are no specific drugs or drug classes that are established to interact directly with the ZNF91 gene. However, given its role in transcriptional regulation and potential implications in diseases, broader therapeutic strategies targeting transcription factors or retrotransposon regulation might indirectly influence ZNF91 activity.

### 4. Pathways and Biological Processes
ZNF91 is involved in several critical biological processes:
- **Gene Regulation**: Functions as a transcription repressor, particularly of retrotransposons.
- **Transcriptional Repression**: Helps maintain genomic integrity by keeping retrotransposon expression in check.
- **Chromatin Remodeling**: Engages with chromatin-modifying complexes to facilitate repression of target genes.
- **Cellular Response to Stress**: May be involved in cellular pathways that respond to factors disrupting genomic integrity.

### Summary
The ZNF91 gene is an essential transcription factor involved in repressing SVA retrotransposons and potentially influencing other genes' expression, such as FCGR2B. Its role in maintaining genome stability underscores its importance in aging and disease. Further research is warranted to uncover its complete functional landscape and potential therapeutic implications.