### Overview of the MANCR Gene

**Gene Symbol**: MANCR  
**Full Name**: Mitochondrial Antisense Non-coding RNA  
**Location**: The MANCR gene is located on chromosome 16.

### Additional Associations

1. **Associated Genes**: 
   - MANCR has been associated with several genes involved in various cellular processes. Some notable genes that have been reported in the literature include:
     - **MIR21**: A microRNA involved in cancer regulation which has been linked to MANCR's function in modulating gene expression.
     - **PTEN**: A tumor suppressor gene that is often involved in pathways associated with cancer.
     - **BCL2**: This gene is known for its role in the regulation of apoptosis, and MANCR may have implications in this pathway.

2. **Aging and Age-related Diseases**:
   - Research has indicated that non-coding RNAs, including MANCR, could play roles in aging and age-related diseases. MANCR may influence mitochondrial function, oxidative stress, and metabolic processes, all of which are critical in the aging process.
   - There is emerging evidence suggesting that MANCR levels can be altered in various cancers, which are often more prevalent with age, suggesting it could have a role in oncogenesis in older adults.

3. **Drug Interactions**:
   - As of now, specific drugs targeting MANCR directly have not yet been well-documented in existing literature. However, its involvement in cellular pathways relevant to cancer (like the PI3K/AKT pathway), suggests potential for indirect interactions with drugs that target these pathways, such as:
     - **PI3K inhibitors**: These drugs are used in cancer treatment and may influence MANCR expression indirectly.
     - **Chemotherapeutics**: Given its association with tumorigenesis, compounds that alter non-coding RNA expression profiles could be explored in relation to MANCR expression.

4. **Pathways and Biological Processes**:
   - **Mitochondrial Function**: MANCR appears to be involved in maintaining mitochondrial functions and may regulate apoptosis via its activities within mitochondria.
   - **Cell Proliferation and Survival**: Studies suggest that MANCR can influence cellular proliferation and may be implicated in cancer cell survival.
   - **Regulation of Gene Expression**: MANCR is known to partake in the regulation of genes associated with various cellular processes, potentially acting as a scaffold for transcription factors or interacting with proteins involved in chromatin remodeling.

### Conclusion

The MANCR gene is an intriguing component of the regulatory landscape of non-coding RNAs, particularly concerning mitochondrial function, gene expression regulation, and potential implications in aging and cancer. While more studies are needed to fully understand the extent of its roles and possible therapeutic avenues, the current knowledge posits MANCR as a significant player in several biological processes and disease states.