### SART3 Gene Overview

**Gene Symbol:** SART3  
**Description:** The SART3 gene encodes an RNA-binding nuclear protein that serves multiple roles in the cellular environment, notably acting as a tumor-rejection antigen and a critical player in splicing machinery. 

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### 1. Associated Genes
While the summaries primarily focus on SART3's interactions within spliceosomal complexes and immune response mechanisms, it may also be associated with the following:

- **MYC:** This is a well-known oncogene, and SART3 is thought to potentially influence its transcription, indicating a relationship between SART3 and MYC in tumor biology.
- **PRPF3:** Critical in spliceosomal function, PRPF3 interacts with SART3 within the U4/U5/U6 tri-snRNP complex, linking splicing activities directly to SART3's role.
- **USP4 and USP15:** These deubiquitinases are linked to SART3 in pathways regulating the stability and function of various proteins, including histones and spliceosomal components.

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### 2. Aging and Age-Related Diseases
Research related to SART3 and aging or age-related diseases is limited, but a few associations can be considered:

- **Tumor Suppression and Cancer:** As SART3 is involved in a tumor-rejection response, its function in the immune system could relate to age-associated changes in cancer susceptibility or progression.
- **Gene Expression Regulation:** The role of SART3 in mRNA splicing suggests it might impact gene expression changes observed during aging, although specific studies are required to validate this hypothesis.

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### 3. Drug Interactions
As of my last knowledge update, no specific drugs or drug classes are widely recognized to interact directly with the SART3 gene. However, due to its potential role in cancer immunotherapy, research may yield treatments that target antigenic properties related to SART3, especially in HLA-A24 positive tumors. 

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### 4. Pathways and Biological Processes
The SART3 gene is involved in several biological pathways and processes, including:

- **mRNA Splicing:** As a U6 snRNP-binding protein, SART3 is crucial in the recycling of spliceosomal components during mRNA processing.
- **Establishment of Spliceosomal Complexes:** It plays a role in assembling U12-type spliceosomes, which are vital for splicing non-canonical intron sequences.
- **Immune Response:** SART3’s identity as a tumor-rejection antigen links it to pathways involved in cellular immunity and response to cancer.
- **Regulation of Gene Expression:** Through its interactions with USP4 and USP15, SART3 has a regulatory role in deubiquitination processes that can modulate gene expression, histone modification, and possibly DNA repair mechanisms.

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These insights into the SART3 gene demonstrate its multifaceted roles in both cellular processes and potential implications in cancer and post-transcriptional regulation. Further research can clarify its specific associations with age-related diseases, drug interactions, and network interactions with other genes.