**NYAP2 Gene Overview:**

The NYAP2 gene (Neuronal, cytosolic protein with a high proportion of asparagines 2) is associated with neuron projection morphogenesis and is known to activate phosphatidylinositol 3-kinase (PI3K), playing a crucial role in the recruitment of the WAVE1 complex which is essential for regulating neuronal morphogenesis.

### 1. Associated Genes:
While the summaries provided do not mention other specific genes, the following genes are known to be functionally related to NYAP2 by virtue of their involvement in similar signaling pathways and biological processes:
- **PIK3CA** and **PIK3CB** - both encode catalytic subunits of the phosphoinositide 3-kinase, participating in the PI3K signaling pathway.
- **WAVE1** - a component of the WAVE complex involved in actin polymerization and neuronal morphogenesis.
- **RAC1** - a small GTPase that activates the WAVE complex, enhancing its role in actin dynamics during neuron development.
- **AKT (also known as Protein Kinase B)** - a downstream effector in the PI3K signaling pathway, linking NYAP2 activity to important neuroprotective and growth-promoting pathways.

### 2. Aging and Age-Related Diseases:
There is limited specific information regarding direct associations between NYAP2 and aging or age-related diseases. However, disruptions in neuronal morphogenesis have been implicated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Given that NYAP2 is involved in signaling pathways that affect neuronal structure and function, it might play a role in these conditions. Further studies are required to clarify any specific contributions of NYAP2 to aging or age-related neurological disorders.

### 3. Drug Interactions:
At the time of this summary, there are no specific FDA-approved drugs directly targeting the NYAP2 gene. However, potential drugs that could modulate the PI3K signaling pathway, such as PI3K inhibitors (e.g., idelalisib, copanlisib), may impact the functional outcomes associated with NYAP2 activity. Additionally, drugs that influence neuronal growth and plasticity may indirectly relate to NYAP2's functions.

### 4. Pathways and Biological Processes:
NYAP2 is implicated in several key biological processes and cellular pathways, including:
- **Neuronal Projection Morphogenesis:** Involvement in shaping neuronal structures.
- **PI3K Signaling Pathway:** A crucial signaling cascade involved in regulating cell growth, proliferation, survival, metabolism, and neuronal responses.
- **Actin Cytoskeleton Organization:** NYAP2's role in recruiting the WAVE complex links it to actin dynamics crucial for cell shape and motility in neurons.
- **Regulation of Gene Expression:** Indirectly through the activation of downstream effectors of the PI3K pathway, influencing cell fate and survival.

These pathways contribute to diverse physiological processes such as neurodevelopment, synaptic plasticity, and potentially neuronal resilience or susceptibility to damage. Further elucidation of NYAP2's roles in these processes is necessary through experimental research.