### ING5 Gene Overview

**Gene Symbol**: ING5  
**Location**: Located on chromosome 2q37.3, the ING5 gene is part of the inhibitor of growth (ING) family, which are crucial for regulating cell proliferation and apoptosis.

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### 1. Associated Genes
Aside from its interaction with p53 and p300, ING5 has been linked with the following genes and proteins:

- **INCA1**: As mentioned, ING5 enhances Fas-induced apoptosis in an INCA1-dependent manner, highlighting its role in apoptosis regulation.
- **MOZ/MORF**: Involvement in the MOZ/MORF complex indicates potential interactions with other regulators of histone acetylation.
- **HBO1**: Related to histone acetylation, suggesting that it may interact with other components of the HBO1 complex and participate in epigenetic regulation.

### 2. Aging and Age-Related Diseases
While specific studies may be limited, some potential associations include:

- **Tumor Suppression and Aging**: The tumor suppressor functions of ING5 imply a role in age-related cancer development. Abnormal regulation of cell growth and apoptosis is often linked to aging.
- **Cell Cycle Regulation**: Disruption in cell cycle regulation has been observed in age-related degenerative diseases, indicating that alterations in ING5 expression may affect these processes.
- **DNA Repair**: The role of histone modification in DNA damage response can also correlate with aging, as the efficiency of DNA repair mechanisms declines with age.

### 3. Drugs and Drug Classes
While specific drugs directly targeting ING5 are not well-documented, the following classes may impact pathways influenced by ING5:

- **Histone Deacetylase Inhibitors (HDACi)**: Since ING5 is involved in histone acetylation, compounds in this class may indirectly affect its activity by altering chromatin accessibility and modifying gene expression patterns.
- **Chemotherapeutic Agents**: Given its role as a tumor suppressor, treatments impacting cell proliferation might interact indirectly or could be more effective in tissues where ING5 is normally expressed.
  
### 4. Pathways and Biological Processes
ING5 is implicated in several critical biological processes and pathways:

- **Cell Cycle Regulation**: ING5 inhibits cell growth and induces delays in S-phase progression, crucial for cancer biology.
- **Apoptosis**: Enhances Fas-induced apoptosis, linking it to programs governing programmed cell death.
- **Transcription Regulation**: Functioning as a transcriptional coactivator, especially through interactions with p53 and complexes associated with histone acetylation.
- **Histone Modification**: As part of HBO1 and MOZ/MORF complexes, ING5 is directly involved in histone acetylation processes affecting chromatin structure and gene expression.
- **DNA Repair and Replication**: Through modulation of chromatin structure, ING5 may play roles in facilitating efficient DNA repair and regulating DNA replication processes.
  
### Summary
The ING5 gene encodes a protein with significant roles in tumor suppression, transcription regulation, and apoptosis. Its involvement in various complexes and pathways ties it to critical cellular processes that could have implications for cancer research, along with potential indirect roles in aging-related conditions and therapies.