### SNORD115-35 Gene Overview

**Gene Symbol:** SNORD115-35  
**Gene Type:** Small nucleolar RNA (snoRNA)  
**Location:** The SNORD115 gene is located in the 15q11.2 region of chromosome 15 in humans.

### 1. Associated Genes

The SNORD115 gene family, which includes SNORD115-35, is part of a more extensive gene cluster also known as the **SNORD115** (or **C/D box snoRNA**) family. Other genes within this region include:

- **SNORD115-1 to SNORD115-35** (multiple snoRNAs belonging to the SNORD115 cluster)
- **SNORD116**, which is also associated with similar functions in ribosomal RNA modification.

**Note:** Besides the immediate family members, there may not be direct associations with other genes. However, snoRNAs are commonly linked to genes involved in the modification of rRNA and the assembly of ribonucleoprotein complexes.

### 2. Aging and Age-Related Diseases

- Although primary research specifically detailing SNORD115-35 in the context of aging or age-related diseases is limited, snoRNAs in general have been implicated in cellular processes critical for brain function and neurodevelopment.
- Dysregulation of snoRNAs, including those in the SNORD115 family, has been associated with disorders such as **Prader-Willi syndrome**, which can involve aspects of aging and metabolic dysfunctions.
- The potential links to neurodegenerative diseases are a growing area of research, considering that alterations in RNA processing and gene expression regulation can contribute to age-related changes in cognitive functions.

### 3. Drug Interactions

- Currently, there are no specific drugs or drug classes directly known to interact with the SNORD115-35 gene. The snoRNAs serve primarily as components of ribonucleoprotein complexes that are involved in rRNA modification rather than as drug targets.
- However, drugs that affect RNA biology (like antisense oligonucleotides or RNA manipulation therapies) could potentially exert indirect effects on the expression or function of snoRNAs like SNORD115-35.

### 4. Pathways and Biological Processes

- **Biogenesis of Ribonucleoproteins:** SNORD115-35 is involved in the biogenesis of ribonucleoprotein particles, where it plays a role in the modification of pre-rRNA substrates into mature rRNA forms.
- **Ribosome Biogenesis:** As a member of the snoRNA family, SNORD115-35 is involved in the maturation and assembly of ribosomes, which are crucial for protein synthesis.
- **Nuclear RNA Processing:** It plays a role in the processing of RNA within the nucleolus, participating in the modification of rRNA transcripts.

### Conclusion

SNORD115-35 is an essential small nucleolar RNA involved in critical processes related to ribosomal RNA modification and ribosome biogenesis, with broader implications that may intersect with aging and neurodevelopmental disorders. However, direct relationships to specific aging-related diseases, drugs, or external gene interactions remain areas for further research.