### ITGA9-AS1 Gene Summary

**Gene Symbol**: ITGA9-AS1

**General Overview**:
ITGA9-AS1 is a long non-coding RNA (lncRNA) gene that has been implicated in various biological processes. Long non-coding RNAs play crucial roles in the regulation of gene expression and cellular processes.

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### 1. Associated Genes
While the specific summaries from NCBI and UniProt may not detail all associated genes, common associations with ITGA9-AS1 can include:

- **ITGA9**: As a natural antisense transcript, ITGA9-AS1 is often closely linked to the ITGA9 gene, which encodes the integrin alpha 9 protein involved in cell adhesion.
- Other genes that may exhibit transcriptional or regulatory interplay with ITGA9-AS1 depending on experimental contexts include genes in pathways related to cell adhesion, tissue remodeling, and tumorigenesis.

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### 2. Aging and Age-Related Diseases
Although specific studies directly linking ITGA9-AS1 to aging or age-related diseases may be limited, lncRNAs are generally implicated in cellular processes associated with aging, such as:

- Regulation of senescence
- Modulation of inflammation
- Influence on cellular differentiation and apoptosis

Research suggests that lncRNAs can play roles in age-related pathologies, including cancer, cardiovascular diseases, and neurodegenerative disorders. Any contributions of ITGA9-AS1 would likely be linked to these overarching themes.

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### 3. Drug Interaction
Currently, there is limited specific data regarding drugs or drug classes that interact directly with ITGA9-AS1. However, given that lncRNAs often influence gene expression and cellular pathways related to drug metabolism and efficacy, potential indirect interactions may occur through general mechanisms, especially in the context of cancer therapeutics, where integrins (like ITGA9) can play roles in metastasis and treatment resistance.

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### 4. Pathways and Biological Processes
ITGA9-AS1 is involved in several biological pathways and processes, including:

- **Cell Adhesion**: As it is associated with the ITGA9 gene, it plays a role in the modulation of integrin-mediated adhesion.
- **Tumor Microenvironment Interaction**: Regulation of cellular interactions within the tumor microenvironment, influencing tumor growth and metastasis.
- **Inflammatory Response**: May be implicated in the regulation of inflammatory pathways, although direct evidence is context-dependent.

Specific molecular pathways that might involve ITGA9-AS1 include:

- **ECM-receptor interaction**: Involves cell adhesion and migration.
- **Regulation of transcription**: As a lncRNA, it may influence the transcription of its neighboring genes or other target genes by acting as a scaffold or regulator in transcriptional complexes.

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### Conclusion
The ITGA9-AS1 gene represents a significant area of interest within the study of long non-coding RNAs, particularly in contexts related to cell adhesion and tumor dynamics. Further research is needed to delineate its specific roles in aging and its interactions with therapeutic modalities.