### HAUS7 Gene Overview

**Gene Symbol:** HAUS7  
**Location:** Chromosome 3 (specifically, 3q26.31)  
**Function:** This gene encodes a subunit of the augmin complex, which is essential for maintaining centrosome and mitotic spindle integrity and plays a crucial role in the completion of cytokinesis. The protein interacts with ubiquitin C-terminal hydrolase 37 (USP37) and is necessary for proper mitotic spindle assembly.

### 1. Associated Genes
HAUS7 is part of the augmin complex and is associated with other genes that encode elements of this complex, including:
- **HAUS1**: Another subunit of the augmin complex involved in microtubule organization.
- **HAUS2**: Also a component of the augmin complex.
- **HAUS3**: Functions with HAUS7 and is involved in the regulation of microtubule dynamics during mitosis.
- **HAUS4**: A component that helps to anchor the augmin complex.
- **HAUS5** and **HAUS6**: Additional subunits essential for the function of the complex.
- **USP37**: The ubiquitin C-terminal hydrolase with which HAUS7 interacts.

### 2. Aging and Age-Related Disease Associations
While specific studies directly linking HAUS7 to aging or aging-related diseases may be limited, there is a broader context to consider:
- Cell division and integrity of cellular components are crucial for biological processes relevant to aging.
- Impairment in mitosis and cytokinesis can lead to cellular senescence, which is a hallmark of aging.
- Alterations in centrosome function have been noted in age-related diseases like cancer, where mitotic errors can lead to genomic instability.
- Further research into the augmin complex may shed light on its role in age-related cellular dysfunctions, particularly in relation to cancer and neurodegenerative diseases.

### 3. Drugs or Drug Classes Interacting with HAUS7
Currently, the direct pharmacological interaction with HAUS7 is not well-documented in major databases. However, since HAUS7 is part of pathways involved in cell division:
- **Antineoplastic agents**: Drugs that target cell division pathways could potentially affect HAUS7 activity indirectly.
- Investigational chemical compounds that modulate the activity of the augmin complex or associated pathways may be explored in ongoing research, particularly in oncology.

### 4. Pathways and Biological Processes
HAUS7 is involved in several key biological pathways and processes:
- **Cell Cycle**: Specifically, it plays a critical role during mitosis in the organization and stabilization of the mitotic spindle.
- **Cytokinesis**: Essential for the successful division of cells at the end of mitosis, avoiding aneuploidy.
- **Microtubule Dynamics**: HAUS7 contributes to the regulation of microtubules, crucial for maintaining cellular structure and transport.
- **Centrosome Regulation**: Participates in the integrity and function of centrosomes, impacting various cellular functions, including signaling pathways and cellular organization.

**Conclusion**: Continued research into HAUS7 and its complex interactions can provide insight into cell division dynamics and potential therapeutic targets, particularly in age-related diseases and cancers.