### PSMD10 Gene Overview

**Gene Symbol**: PSMD10  
**Role**: Encodes a regulatory subunit of the 26S proteasome's PA700/19S complex, vital for ubiquitin-dependent protein degradation.

#### 1. Associated Genes
PSMD10 interacts with several genes relevant to the proteasome pathway and tumorigenesis, including:
- **PSMC1, PSMC2, PSMC4**: Other subunits involved in the 26S proteasome's structure and function.
- **PSMD5**: Another regulatory subunit of the 19S complex.
- **EGFR**: In the context of EGF-induced AKT activation.
- **AKT1**: Involved in cell survival and proliferation pathways related to oncogenesis.
- **RHOA**: As part of the signaling pathway affected by PSMD10 regulating AKT activation.

#### 2. Aging and Age-Related Diseases
Abnormal expression of PSMD10 has been implicated in several age-related phenomena, such as:
- **Tumorigenesis**: Dysregulation is linked to cancer pathways, particularly due to the role of PSMD10 in the assembly of the proteasome complex, contributing to the degradation of tumor suppressors and regulators of cell cycle.
- **Cellular Senescence**: Proteasome function is essential in maintaining cellular homeostasis; poorly regulated proteasomal activity can lead to accumulation of damaged proteins, a hallmark of aging.
- **Neurodegenerative Diseases**: While specific studies linking PSMD10 to neurodegenerative diseases are limited, its role in proteasome function could suggest implications in disorders such as Alzheimer's and Parkinson's diseases.

#### 3. Drug Interactions
There are no specific drugs that interact directly with PSMD10 itself; however, drugs that modulate proteasome activity may indirectly affect the function of PSMD10, including:
- **Proteasome Inhibitors**: Such as Bortezomib (used in multiple myeloma treatment) may influence the components of the proteasome complex and reveal the roles of subunits like PSMD10.
- **Anticancer Drugs**: Some therapies targeting oncogenic signaling pathways may indirectly affect PSMD10's activity due to its role in tumor promotion through AKT activation.

#### 4. Pathways and Biological Processes
PSMD10 is involved in several critical biological pathways:
- **Ubiquitin-Proteasome, Proteolysis Pathways**: Critical for the degradation of ubiquitin-tagged proteins, regulating cell cycle, apoptosis, and stress responses.
- **Signaling Pathways**: Particularly those involved in AKT regulation, including:
  - *EGF receptor signaling pathway*: Influences cell proliferation and survival.
  - *RHOA/ROCK/PTEN pathway*: Alters the signaling cascade modulating AKT activation.
- **Tumorigenesis Pathway**: Plays a pivotal role in oncogenesis via RAS signaling pathways, indicating its importance in cancer development.

### Conclusion
PSMD10 is a multifaceted gene that encodes for crucial components integral to the 26S proteasome's regulation, involved in protein degradation, cancer pathways, cellular aging, and potentially neurodegenerative processes. Its interactions and functions implicate it in various cellular mechanisms, making it a significant focus for further research in both oncology and aging-related studies.