### CCDC181 Gene Summary

**Gene Symbol:** CCDC181  
**Function:** CCDC181 is a predicted microtubule-binding protein that plays a crucial role in the development of sperm cells, particularly during the elongation phase of spermatids. It localizes to the microtubular manchette, a structure involved in the assembly and maturation of the sperm tail.

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### 1. Associated Genes

CCDC181 may share functional relationships with various genes, especially those involved in spermatogenesis and microtubule dynamics. While specific directly-associated genes are not frequently highlighted, genes such as **TUBA1A** (tubulin alpha 1a) and **KIF5A** (kinesin family member 5A), which are involved in microtubule assembly and transport, might be indirectly related due to their shared roles in microtubule function in cells.

### 2. Aging and Age-Related Diseases

As of my last knowledge update in October 2023, specific aging-related studies directly focusing on CCDC181 are limited. However, disruptions in spermatogenesis and related processes can have implications for fertility as males age. A decline in spermatogenic function can lead to age-related infertility, though it should be noted that a direct link between CCDC181 and distinct age-related diseases has not been established explicitly in the literature. Investigating functional mutations or expression levels of CCDC181 in relation to age-related decline in male reproductive health is an area worth exploring.

### 3. Drug Interactions

Currently, there are no well-documented drugs or drug classes explicitly known to interact with CCDC181. However, drugs that affect cellular microtubule dynamics, such as **taxanes** (e.g., Paclitaxel) or **vinca alkaloids** (e.g., Vincristine), could potentially affect the pathways where CCDC181 is involved. Investigation into specific interactions will require further empirical studies.

### 4. Pathways and Biological Processes

CCDC181 is believed to be involved in the following biological processes:

- **Spermatogenesis:** It plays a vital role in the development and maturation of sperm cells.
- **Microtubule Organization:** Its predicted microtubule binding activity suggests a role in microtubule dynamics and organization within cellular structures, particularly in the manchette.
  
Overall, CCDC181 represents a specialized protein with significant implications in male fertility. Continued research may yield insights into its associations with various reproductive processes as well as its potential relevance in male age-related reproductive decline.