### FBXO2 Gene Overview

**Gene Symbol: FBXO2**  
**Gene Description:** The FBXO2 gene encodes a member of the F-box protein family, important components of the SCF (SKP1-Cullin-F-box) ubiquitin ligase complex, which is essential for the ubiquitination and targeted degradation of proteins. 

### 1. Associated Genes
FBXO2 is known to interact with various other genes through functional and biochemical pathways, although specific genes may not be explicitly mentioned in the provided summaries. Some genes known to have association through the ubiquitination pathway include:
- **SKP1:** Part of the SCF complex, crucial for F-box protein functioning.
- **CUL1:** Also part of the SCF ligase complex.
- **UBE2E1:** A ubiquitin-conjugating enzyme involved in ubiquitination pathways.

Additionally, genes involved in the endoplasmic reticulum-associated degradation (ERAD) pathway may be indirectly associated. 

### 2. Aging and Age-Related Diseases
FBXO2 has been implicated in various cellular processes that are linked to aging and age-related diseases:
- **Cellular Senescence:** FBXO2 may participate in regulating cellular senescence through protein degradation mechanisms, which are crucial for maintaining cellular function and longevity.
- **Neurodegenerative Disorders:** Given its similarity to the rat NFB42 protein, FBXO2 could potentially influence neurodegenerative processes, as misfolded proteins play a role in diseases like Alzheimer’s and Parkinson’s.
- **Cancer:** Aberrant expression of FBXO2 has been linked to various cancers, suggesting its role in tumorigenesis possibly due to deregulation of the cell cycle or apoptosis pathways.

### 3. Interacting Drugs or Drug Classes
Specific drugs or drug classes that interact with FBXO2 are not well-defined in the literature since FBXO2 functions primarily as a substrate recognition component in ubiquitination. However, general classes of drugs that might influence ubiquitin-proteasome pathways include:
- **Proteasome Inhibitors:** Such as Bortezomib, which may affect the degradation of proteins targeted by FBXO2.
- **Histone Deacetylase Inhibitors:** Such as Vorinostat, which could modulate the expression of genes involved in the ubiquitination process.

### 4. Pathways and Biological Processes
FBXO2 is involved in several critical biological processes and pathways:
- **Ubiquitin-Proteasome Pathway:** FBXO2 is a crucial part of the SCF complex facilitating ubiquitination of target proteins for proteasomal degradation.
- **Endoplasmic Reticulum-Associated Degradation (ERAD):** FBXO2 mediates the recognition and ubiquitination of misfolded glycoproteins in the ER for degradation.
- **Cellular Response to Stress:** Involved in pathways responding to cellular stress by controlling the degradation of misfolded or damaged proteins.
- **Neuronal Function:** Potentially aids in maintaining the postmitotic state of neurons and thus is essential in neuronal development and function.

### Conclusion
FBXO2 plays a pivotal role in protein quality control via ubiquitination, impacting various biological processes and potentially influencing aging and age-related diseases. While its specific interactions with drugs are less documented, it is implicated in several pathways critical for cellular health and function.