### UHRF2 Gene Overview

The **UHRF2** gene (Ubiquitin-like with PHD and RING finger domains 2) encodes a nuclear protein that plays critical roles in cellular processes, notably in cell cycle regulation, DNA repair, and maintaining epigenetic states. It is characterized by its ability to act as an E3 ubiquitin ligase, targeting specific substrates for ubiquitination, which is integral for proteasomal degradation.

### Other Associated Genes
In addition to known interactions with **PCNP**, **CCND1**, **CCNE1**, and **CDKN1A**, UHRF2 has been associated with the following genes:
- **UHRF1**: Often studied together due to overlapping functions in DNA maintenance and repair processes.
- **FANCD2**: Involved in the DNA damage repair pathway and interstrand crosslink repair.
- **ATR**: Engages in the DNA damage response mechanism related to UV damage.

### Age-Related Details
Research has suggested possible roles for UHRF2 in aging and age-related diseases, particularly:
- **Cellular Senescence**: UHRF2-mediated regulation of cell cycle proteins may influence cellular senescence and contribute to age-related decline in tissue function.
- **Neurodegenerative Disorders**: Epigenetic modifications linked to UHRF2 involvement in maintaining neuronal gene expression have implications for diseases such as Parkinson’s and Alzheimer’s.

Alterations in UHRF2's function can lead to dysregulated cell cycle progression and increased susceptibility to DNA damage, processes often implicated in aging and age-related pathologies.

### Drug Interactions
While specific drugs tailored to directly target UHRF2 have not been extensively documented, compounds that influence ubiquitin ligases or DNA repair pathways could indirectly affect UHRF2 functions. Notable drug classes include:
- **Histone Deacetylase Inhibitors (HDACi)**: Compounds like Vorinostat and Romidepsin, which can lead to epigenetic modifications.
- **Proteasome Inhibitors**: Such as Bortezomib, which may intersect with the ubiquitin-proteasome system where UHRF2 plays a role.

### Involved Pathways and Biological Processes
UHRF2 has been linked to various biological processes and signaling pathways, including:
- **DNA Repair Mechanisms**: Critical for maintaining genomic integrity, particularly in the context of interstrand crosslink repair through interaction with FANCD2.
- **Cell Cycle Regulation**: UHRF2 ubiquitinates key cell cycle proteins, particularly cyclins, impacting transitions such as G1 phase arrest.
- **Epigenetic Regulation**: Involvement in maintaining DNA methylation and histone modification patterns, particularly concerning 5-hydroxymethylcytosine (5hmC) recognition and substrate recruitment.
- **Response to DNA Damage**: Participation in pathways activated by DNA damage, including initiating repair mechanisms after UV damage through interaction with ATR.

### Conclusion
The UHRF2 gene is a multifaceted player in cell cycle regulation, DNA repair, and epigenetic maintenance, with implications that stretch from cancer biology to neurodegeneration and aging. Continued exploration of its interactions, regulatory mechanisms, and potential drug targets will be crucial for therapeutic advancements.