### DPF2 Gene Overview

**Gene Symbol**: DPF2  
**Location**: This gene is located on chromosome 3 in humans (3q21.1).

#### Summary
The DPF2 (Double PHD Finger 2) gene encodes a protein that is part of the d4 domain family, characterized by a zinc finger-like motif. The protein functions as a transcription factor involved in the apoptotic response following deprivation of survival factors and is critical for the rapid growth and turnover of hematopoietic cells. Additionally, DPF2 plays a role in modulating myeloid differentiation and possibly influences lymphoid cell development and maturation. The gene has been proposed as a candidate for multiple endocrine neoplasia type I, a hereditary cancer syndrome.

#### 1. Associated Genes
While the provided summaries do not specify other genes directly associated with DPF2, some relevant gene relationships based on gene interaction networks and pathways include:
- **NF-kappa-B** pathway related genes (like **IKBKB**, **REL**, **NFKB1**) that are involved in the immune response.
- **RUNX1**, a critical transcription factor in hematopoiesis, where DPF2 may have regulatory interactions.
- **HIST1H3** and **HIST1H4**, which have modified histones that DPF2 binds to for transcription regulation.

#### 2. Aging and Age-Related Diseases
Research has suggested that alterations in transcription factors, including DPF2, might influence cellular aging, particularly through mechanisms affecting apoptosis and cell turnover. While direct associations of DPF2 with aging or age-related diseases have not been definitively established, its role in hematopoietic cell regulation could suggest implications in age-related hematological conditions or decline in immune function with age. 

#### 3. Drug Interactions
Specific drugs or drug classes that interact with DPF2 are not explicitly well-documented in the literature. However, as DPF2 is involved in transcriptional regulation and pathways related to hematopoiesis and cancer, it may affect or be affected by:
- **Histone deacetylase inhibitors (e.g., Vorinostat)**, which can impact global gene expression, including that regulated by DPF2 due to its interaction with histones.
- **Antineoplastic agents** targeting pathways associated with NF-kappa-B could also have indirect effects on the gene's regulatory mechanisms.

#### 4. Pathways and Biological Processes
DPF2 is involved in several key biological processes and pathways:

- **Regulation of gene expression**: Through binding to histones, it modulates transcription of target genes.
- **Apoptosis**: DPF2 is implicated in regulating apoptotic pathways, especially during cell survival factor deprivation.
- **Hematopoiesis**: The regulation of myeloid lineage cell differentiation is a key role, suggesting its importance in blood cell development.
- **Immune response**: DPF2 has been linked to the regulation of non-canonical NF-kappa-B signaling, which is important for immune responses.
  
In summary, DPF2 plays a multifaceted role in transcriptional regulation, apoptosis, and hematopoiesis while also holding potential links to oncology and possibly aging mechanisms. Further research is necessary to elucidate the full scope of its functions and implications in various conditions.