The DLGAP2-AS1 gene, which stands for "DLGAP2 antisense RNA 1," is a long non-coding RNA (lncRNA) located on chromosome 4. DLGAP2-AS1 is believed to have regulatory roles in gene expression, influencing various biological processes and pathways.

### 1. Associated Genes
While comprehensive interaction lists may vary, DLGAP2-AS1 has been linked to the following genes:
- **DLGAP2**: A primary gene of interest, as DLGAP2-AS1 acts in relation to its sense counterpart. It is involved in synaptic interactions and neuronal signaling.
- **Neurodevelopment-related genes**: Other genes related to neural development and function may exhibit regulatory relationships or expression co-dependencies with DLGAP2-AS1, including genes like **NRXN1** (neurexins) and **PSD-95**.

### 2. Aging and Age-Related Diseases
Research regarding DLGAP2-AS1 in the context of aging or age-related diseases specifically is limited; however, lncRNAs generally play roles in cellular senescence and the regulation of stem cell functions. Dysregulation of long non-coding RNAs can occur with aging and is implicated in age-related disorders such as:
- **Neurodegenerative diseases**: Given DLGAP2's involvement in neuronal function, alterations in lncRNA expression might impact conditions like Alzheimer's disease and other forms of dementia.
- **Cancer**: Some studies suggest that changes in the expression of lncRNAs, including DLGAP2-AS1, might contribute to various cancers, informed by their roles in cell proliferation and apoptosis.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes that are directly known to interact with DLGAP2-AS1. However, because it is involved in pathways that may be altered in cancer and neurodegenerative diseases, it could potentially influence responses to therapeutics in those contexts (e.g., chemotherapeutic agents or neuroprotective drugs) indirectly through the modulation of relevant signaling pathways.

### 4. Pathways and Biological Processes
DLGAP2-AS1 is associated with several biological processes:
- **Neuronal development and maintenance**: As an antisense RNA of DLGAP2, it is assumed to influence synaptic plasticity, neural signaling, and cognitive functions.
- **Cell Adhesion and Synaptic Transmission**: It may participate in pathways important for synaptic organization and function, promoting appropriate neuronal connections and communication.
- **Gene Regulation**: Being a long non-coding RNA, DLGAP2-AS1 might contribute to the regulation of gene expression at the transcriptional or post-transcriptional levels.
- **Cellular Response to Stimuli**: Its expression may respond to various physiological and pathological stimuli, impacting cellular stress responses.

Overall, while DLGAP2-AS1 has functional roles, the understanding of its implications in aging, age-related diseases, and drug interactions remains an area of active research and may evolve as more studies are conducted.