### SNORD115-1 Gene Overview

**Gene Symbol**: SNORD115-1  
**Location**: Found on chromosome 15, within the Prader-Willi/Angelman syndrome (PWS) region.  

#### General Features
SNORD115-1 is a member of the small nucleolar RNA (snoRNA) gene family, and it plays a role in the regulation of RNA metabolism. It forms part of a larger cluster of snoRNAs, often involved in guiding modifications of other RNAs, particularly ribosomal RNAs and small nuclear RNAs.

### 1. Associated Genes
In addition to the serotonin receptor 2C (HTR2C), SNORD115-1 may also interact or have regulatory implications with the following genes:
- **SNRPN** (Small Nuclear Ribonucleoprotein Polypeptide N): Part of the same IC-SNURF-SNRPN transcript and involved in RNA processing.
- **SNURF** (SNURF-SNRPN gene): Another snoRNA gene within the cluster that exhibits similar imprinting effects.
- **PRPF8**: Involved in the spliceosome assembly; when considering RNA splicing in general.
- Other members of the SNORD family and various serotonin-related genes may also be indirectly impacted.

### 2. Aging and Age-Related Diseases
While specifically researching aging associations has not pinpointed direct correlations with SNORD115-1, snoRNAs in general have been implicated in the regulation of cell growth and differentiation, which may suggest roles in the aging process. Dysregulation of snoRNA functions has been observed in various age-related diseases, including:
- Cancer: Altered expression of snoRNAs, including those clustered with SNORD115-1, has been associated with tumorigenesis and progression.
- Neurodegeneration: Some studies suggest that snoRNAs can influence synaptic function and may play roles in conditions like Alzheimer's disease.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes directly known to interact with SNORD115-1 based on existing literature. However, alterations in serotonin signaling (via HTR2C) can be influenced by various psychotropic medications (e.g., SSRIs) that target serotonin pathways. Given SNORD115-1's potential role in HTR2C alternative splicing, drugs affecting these pathways might indirectly influence SNORD115-1 activity.

### 4. Pathways and Biological Processes
SNORD115-1 is involved in several cellular processes which include:
- **RNA Processing**: Guided modification of rRNA and potentially influencing the splicing of pre-mRNA transcripts.
- **Alternative Splicing**: May affect the splicing patterns of the serotonin receptor HTR2C, which is significant in neurobiological contexts like mood regulation.
- **Imprinting**: Part of the paternally imprinted region associated with Prader-Willi and Angelman syndromes; though its role in PWS manifestation is limited.
- **Nucleolar Activity**: Participates in the biogenesis and regulation of ribonucleoprotein complexes.

In summary, while SNORD115-1 is primarily recognized for its role in snoRNA pathways, its implications in aging, disease association, drug interactions, and specific biological processes are still under investigation and warrant further research for conclusive understanding.