### FLRT2 Gene Overview

**Gene Symbol:** FLRT2  
**Location:** Chromosome 3 (3p14.3)  
**Protein Length:** The protein consists of approximately 507 amino acids.

### 1. Associated Genes

In addition to its interactions with ADGRL3 (latrophilin 3) and UNC5D, FLRT2 has been associated with several other genes and proteins that play roles in neurodevelopment and cellular signaling:

- **FLRT1:** A related member of the FLRT family that may have overlapping functions.
- **FLRT3:** Another homologue that could share functional pathways.
- **UNC5 family:** Other members like UNC5A and UNC5B, which also mediate cell guidance.
- **Fibroblast Growth Factor Receptor (FGFR):** Components in FGF signaling pathways.
- **Neogenin:** A receptor that functions in axon guidance and cellular adhesion.

### 2. Aging and Age-Related Diseases

Although specific studies directly linking FLRT2 to aging or age-related diseases are limited, several aspects can be noted:

- **Neurodevelopment:** FLRT2’s role in neuron migration and guidance during development raises concerns about its implications in neurodegeneration, as improper signaling could lead to age-related neurodevelopmental disorders or cognitive decline.
- **Vascular Development:** Established functions in vascular development suggest FLRT2 might play a role in age-related vascular diseases, such as atherosclerosis or hypertension, where vascular homeostasis becomes disrupted over time.
- **Cardiac Development:** Since FLRT2 is important for cardiac basement membrane organization, dysregulation may contribute to age-associated cardiac conditions, such as heart failure or hypertrophy.

### 3. Drug Interactions

Currently, no specific drugs or drug classes are directly associated with FLRT2 interactions in pharmacological databases. However, drugs modulating fibroblast growth factor (FGF) signaling could indirectly affect FLRT2 functions given its involvement in FGF-mediated pathways. Some examples include:

- **FGF Receptor Inhibitors:** These may influence the pathways FLRT2 is involved in, given its interactions with the FGF signaling cascade.
- **Neuroprotective Agents:** Drugs targeting neurodegenerative pathways could potentially have downstream effects on FLRT2 functions due to its role in neuronal growth and guidance.

### 4. Pathways and Biological Processes

FLRT2 is involved in several key pathways and biological processes:

- **Cell-Cell Adhesion:** FLRT2 mediates homophilic and heterophilic adhesion, critical for neural and vascular development.
- **Neuronal Development:** Plays key roles in neuron migration and axon guidance, especially during embryogenesis.
- **WNT Signaling Pathways:** May be involved in non-canonical WNT signaling, influencing cell fate and migration.
- **Cardiac Development:** Necessary for the proper organization of the cardiac basement membrane and morphogenesis of the heart.
- **FGF Signaling:** Participates in cellular responses to fibroblast growth factors, which are crucial for a variety of developmental processes.

### Conclusion

Overall, FLRT2 plays essential roles in cellular adhesion, neuron development, and cardiac morphogenesis. Continued research may elucidate further connections to aging and potential drug interactions for therapeutic developments.