**Gene Summary of SNORD114-14**

**Gene Symbol:** SNORD114-14  
**Type:** Small nucleolar RNA (snoRNA)  

**Overview:**  
The SNORD114-14 gene is a member of the C/D box small nucleolar RNA (snoRNA) family. These RNA molecules are part of the snoRNA family that primarily perform roles in the modification and processing of ribosomal RNA (rRNA). Specifically, snoRNAs guide the chemical modification of rRNA and assist in pre-rRNA processing, which is essential for the biogenesis of ribosomes.

### 1. Associated Genes
While specific gene associations are often determined by functional studies and large-scale genomic data analyses, SNORD114-14 is known to be associated with various genes involved in rRNA processing and ribosome biogenesis indirectly via its role in guiding modifications of rRNA. Additionally, interactions related to gene expression processes may involve:

- Other SNORD114 family members (like SNORD114-1, SNORD114-2, etc.)
- Genes involved in the biogenesis of the snoRNAs themselves (e.g., DKC1, which is associated with dyskeratosis congenita).

### 2. Aging and Age-Related Diseases
While specific studies focusing on SNORD114-14 directly in relation to aging or age-related diseases are scarce, snoRNAs, in general, have been implicated in cellular processes that could be related to aging. Alterations in snoRNA expression and function may be observed in age-related diseases such as cancer or neurodegenerative disorders. Further research is necessary to clarify the specific role of SNORD114-14 in these contexts.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes directly known to interact with SNORD114-14 as it primarily functions in the regulation of rRNA processing rather than a direct target for drug action. Nonetheless, compounds that influence overall ribosome biogenesis, protein synthesis, or that interact with other components of the RNA processing machinery may have downstream effects on targets like SNORD114-14. For specific drug interactions, further research in pharmacogenomics may clarify potential indirect effects.

### 4. Pathways and Biological Processes
SNORD114-14 is involved in several critical biological processes, including:
- **Ribosome biogenesis:** Acting as a guide for the modification of rRNA, which is critical for the assembly of ribosomes.
- **Regulation of RNA processing:** Participating in pre-rRNA processing and maturation.
- **rRNA methylation:** Facilitating the 2'-O-methylation of rRNA, which is an important modification that affects ribosome function.

**Relevant Pathways:**
- **Ribosome Biogenesis in eukaryotes**
- **SnoRNA-mediated modification of rRNA**
- **Regulation of gene expression**

Further studies continue to explore the nuanced roles that snoRNAs, including SNORD114-14, play across various cell types, developmental processes, and disease states, particularly in the context of RNA biology and post-transcriptional regulation.