### Gene Summary

**Gene Symbol**: SNORD116-4

SNORD116-4 is a small nucleolar RNA (snoRNA) gene located within the imprinted region of the 15q11-q13 chromosome, which is known to be associated with Prader-Willi Syndrome and other neurodevelopmental disorders. SnoRNAs are primarily involved in the biogenesis of ribosomal RNA through methylation and pseudouridylation processes, playing essential roles in the processing and modification of ribosomal RNA.

### Associated Genes

While specific associations can vary, SNORD116-4 is known to be part of a cluster of snoRNAs located in the same genomic region, primarily affecting genes involved in ribosomal function and cellular growth. Some genes that could be related or affected by genetic interactions with SNORD116-4 include:

1. **SNORD116** (the larger snoRNA cluster associated with Prader-Willi Syndrome).
2. **UBE3A** - another gene associated within the imprinted region of 15q11-q13 that plays a role in synaptic function and is related to Angelman Syndrome.

### Aging and Age-Related Diseases

There has not been extensive research directly linking SNORD116-4 to aging or age-related diseases. However, given its involvement in the regulation of cell growth and ribosomal function, disruptions in the function of snoRNAs have been implicated in various age-related conditions and neurodegenerative diseases. Some conditions like Alzheimer's Disease (AD) may potentially connect to altered expression of snoRNAs, but specific associations with SNORD116-4 are yet to be determined.

### Drug Interactions

Currently, there are no well-established drugs or drug classes known to directly interact with SNORD116-4. However, because of the role of snoRNAs in cellular processes, compounds that modify RNA processing or transcription may indirectly affect the function of this gene. Future research might uncover therapeutic pathways or pharmacological agents that could target the pathways involving SNORD116-4.

### Pathways and Biological Processes

SNORD116-4 is involved in several biological processes, including:

1. **Ribosomal RNA processing** – as a snoRNA, it participates in the methylation and pseudouridylation of ribosomal RNAs.
2. **Regulation of gene expression** – snoRNAs often play roles in the epigenetic regulation of nearby genes due to their localization and potential regulatory function on transcriptional machinery.
3. **Precursor rRNA metabolic process** – contributing to the maturation of ribosomal RNA molecules essential for protein synthesis.

### Summary

SNORD116-4 is a snoRNA located in a genomic region associated with neurodevelopmental disorders. While its direct connections to age-related diseases and specific drug interactions remain limited, it is crucial for cellular growth and ribosomal RNA maturation. Future studies are required to elucidate its roles more precisely in aging and various diseases.