### MTHFD2P3 Gene Overview

**Gene Symbol:** MTHFD2P3  
**Location:** MTHFD2P3 is a pseudogene related to the MTHFD2 gene, which is located on the human genome. Pseudogenes generally do not encode functional proteins but may have regulatory roles or be involved in RNA gene regulation mechanisms.

#### 1. Associated Genes
MTHFD2P3 is linked with several other genes, primarily within the folate metabolism pathway, including:
- **MTHFD2**: This is the primary gene of interest in the context of folate metabolism, encoding a key enzyme involved in converting tetrahydrofolate derivatives.
- **MTHFD1**: This gene also encodes for a methylenetetrahydrofolate dehydrogenase, which plays a significant role in folate metabolism.
- **MTHFR**: Methylenetetrahydrofolate reductase is crucial for various metabolic pathways in the body, particularly in converting dietary folate into a usable form.

#### 2. Aging and Age-Related Diseases
While there may be limited direct studies specifically focusing on MTHFD2P3 and its role in aging or age-related diseases due to its classification as a pseudogene, its associated gene MTHFD2 is known to contribute to folate metabolism, which is vital for DNA synthesis and repair. Deficiencies in folate metabolism have been implicated in various age-related diseases such as:
- **Neurodegenerative Disorders:** Impaired methylation processes linked to folate deficiency can influence neurological health.
- **Cardiovascular Diseases:** Homocysteine metabolism (influenced by folate levels) has a well-established connection to cardiovascular health in aging populations.

#### 3. Drug Interactions
Due to the nature of MTHFD2P3 as a pseudogene with no known functional protein product, direct drug interactions are not well documented. However, drugs affecting folate metabolism might indirectly relate:
- **Methotrexate**: An antimetabolite and antifolate drug.
- **Folic Acid Supplements**: Used to prevent folate deficiency and to support reproductive health.

#### 4. Pathways and Biological Processes
MTHFD2P3, as a pseudogene, does not directly participate in biological processes. However, its associated gene MTHFD2 is involved in several critical pathways, including:
- **Folate Metabolism**: Involvement in converting dietary folate into bioactive forms necessary for nucleotide synthesis and methylation reactions.
- **One-carbon Metabolic Pathway**: Essential in amino acid synthesis and nucleotide metabolism.
- **Cellular Responses to Oxidative Stress**: As it relates to maintenance of DNA integrity and repair processes.

MTHFD2P3 potentially acts as a regulatory element that may influence MTHFD2 expression and its associated pathways indirectly, but more research would be required to explore these associations fully. 

### Conclusion
Overall, MTHFD2P3 is a pseudogene associated primarily with the MTHFD2 gene and its pathway in folate metabolism, with potential implications in age-related health and drug interactions surrounding folate pathways. However, findings remain limited due to its classification as a pseudogene with indirect functional significance.