### Gene Summary: PHKA1-AS1

**Gene Symbol:** PHKA1-AS1

**General Description:** PHKA1-AS1 is a long non-coding RNA (lncRNA) that is an antisense transcript of the PHKA1 gene. The biological functions of lncRNAs like PHKA1-AS1 are still being explored, but they are known to be involved in various regulatory processes, including gene expression modulation, chromatin remodeling, and interaction with transcription factors.

### Associations with Other Genes

1. **PHKA1 (Phosphorylase Kinase, Alpha 1)**: As an antisense transcript, PHKA1-AS1 is directly associated with the PHKA1 gene.
2. **Potential interactions with other lncRNAs and coding genes** have been indicated in some studies, although specific gene names may vary and research is ongoing.

### Aging and Age-Related Diseases

- **Aging Associations**: The specific role of PHKA1-AS1 in aging is still being researched, but lncRNAs have been implicated in processes related to cellular senescence and longevity.
- **Age-Related Diseases**: Potential associations with metabolic disorders (especially those affecting glucose metabolism, given the role of PHKA1) may have implications in conditions such as diabetes, which can be considered age-related given population age dynamics.

### Drug Interactions

Currently, specific drugs or drug classes that interact explicitly with PHKA1-AS1 are not well-documented in available resources. However, it is noted that lncRNAs can modulate drug responses and resistance mechanisms, particularly in cancer treatment, which could be an area for future exploration.

### Pathways and Biological Processes

- **Metabolic Pathway Involvement**: Given its association with PHKA1, PHKA1-AS1 may be involved in pathways related to glycogen metabolism and signaling pathways associated with insulin and glucose regulation.
- **Regulatory Processes**: As a lncRNA, PHKA1-AS1 is likely involved in the regulation of transcription and gene expression, epigenetic regulation processes, and interactions with various protein complexes.
- Potential involvement in **cellular signaling pathways** that govern cell growth, metabolism, and response to external stressors.

### Summary

In conclusion, while specific functional details regarding PHKA1-AS1 are still emerging, its association with the PHKA1 gene aligns it with critical metabolic functions and potentially, the regulation of pathways related to aging and age-related diseases. Further research is essential to clarify the exact roles of lncRNAs like PHKA1-AS1 in health and disease.