### Overview of DDX11L5 Gene

**Gene Symbol:** DDX11L5  
**Gene Description:** The DDX11L5 gene encodes a member of the DEAD (Asp-Glu-Ala-Asp) box protein family, which are RNA helicases involved in various aspects of RNA metabolism, including splicing, translation, and ribosome biogenesis. DEAD box proteins are characterized by the presence of a conserved DEAD motif. They play critical roles in cellular processes such as RNA unwinding, ribonucleoprotein complex remodeling, and transcription regulation.

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### 1. Associated Genes

While the specific gene summary from NCBI and UniProt may not have detailed associated genes, DDX11L5 is often studied in conjunction with:

- **DDX11:** A paralog involved in processes critical for DNA replication and repair.
- **DDX5:** Implicated in RNA metabolism and potentially linked with cancer processes.
- **DDX20:** Associated with transcription regulation and implicated in cancer.

Additionally, being part of the DEAD box family, DDX11L5 may also interact functionally with many other RNA metabolism-related genes and proteins.

### 2. Aging and Age-Related Diseases

Research directly implicating DDX11L5 in aging or age-related diseases is limited. However, given the role of helicases in genome stability and cellular stress responses, alterations or mutations in DEAD box proteins can potentially impact:

- **Cancer:** Defects in helicases might lead to genomic instability, a hallmark of cancer, which tends to increase with age.
- **Neurodegenerative diseases:** Dysregulation of RNA metabolism is often observed in age-related neurodegenerative diseases.
  
Any age-related implications for DDX11L5 are likely to stem from its general roles in RNA metabolism, DNA repair, and cellular stress responses rather than specific studies directly correlating this gene with aging.

### 3. Drug Interactions 

As of the latest update in October 2023, specific drugs or drug classes that interact directly with DDX11L5 have not been well characterized. However, general classes of drugs that might interact with helicase activity include:

- **Antiviral drugs:** Some act through mechanisms that involve RNA helicases.
- **Chemotherapeutic agents:** These may impact RNA metabolism and helicase function indirectly.

Further research may be required to pinpoint specific drugs affecting DDX11L5.

### 4. Pathways and Biological Processes

DDX11L5 is involved in several key biological processes:

- **RNA Metabolism:** It plays a role in RNA unwinding and processing, which is critical for mRNA splicing and ribosome assembly.
- **Regulation of Gene Expression:** By facilitating interactions between RNA and protein complexes, it influences the stability and translation of mRNAs.
- **Cell Cycle Regulation:** RNA helicases are often implicated in regulating progression through the cell cycle, reflecting their importance in cellular proliferation.

While specific pathways involving DDX11L5 may not be fully characterized, it can be inferred that it would interact within various cellular networks, especially those regulating mRNA dynamics, ribosomal biogenesis, and possibly stress response pathways.

### Conclusion

The DDX11L5 gene encodes an essential RNA helicase with potential implications in various cellular processes, and while research is ongoing, its precise role in aging, disease, drug interactions, and specific pathways warrants further investigation.