### FKBP1A Gene Overview

**Gene Symbol:** FKBP1A  
**Location:** Chromosome 1  
**Protein Name:** FK506-binding protein 12 (FKBP12)

#### Function and Role
The FKBP1A gene encodes a member of the immunophilin protein family. This protein possesses the function of a cis-trans prolyl isomerase, critically involved in the acceleration of protein folding by catalyzing the isomerization of proline imidic peptide bonds. Notably, FKBP1A plays a significant role in immunoregulation and is associated with several essential cellular functions.

#### Interactions
- FKBP1A interacts with and modulates various intracellular signaling pathways, particularly relating to the TGF-beta receptor and calcium channels.
- It binds immunosuppressants like FK506 and rapamycin, which are important in therapeutic contexts.
- It is known to interact with:
  - Type I TGF-beta receptor (TGFBR1)
  - SMAD7
  - ACVR1B (Activin A receptor)
  - Ryanodine receptor RYR1 complex
  - Various calcium release channels

#### Gene Associations
In addition to interactions with the TGF-beta and activin signaling pathways, FKBP1A is also associated with the following genes (not included in the summary):
- **CALM1 (Calmodulin 1)** - involved in calcium signaling.
- **RYR2 (Ryanodine Receptor 2)** - another calcium channel closely related to FKBP1A functions in muscle contraction and cardiac function.

#### Aging and Age-Related Diseases
Research has indicated that alterations in FKBP1A expression or function may have implications for age-related diseases, particularly cardiovascular conditions. Specific details include:
- **Noncompaction of Left Ventricular Myocardium:** In mouse models, deletion of FKBP1A has been linked to congenital heart defects, which may mirror changes seen in aging populations or in patients with heart diseases. 
- **Protein Homeostasis:** Dysregulation in the protein folding and trafficking functions of FKBP1A may contribute to age-related cellular stress and degenerative diseases.

#### Drug Interactions
FKBP1A interacts with drugs, notably:
- **Immunosuppressants:**
  - FK506 (Tacrolimus)
  - Rapamycin (Sirolimus)
  
These drugs target FKBP1A for their immunosuppressive properties and are widely used in transplant medicine and the treatment of autoimmune diseases.

#### Biological Pathways and Processes
The FKBP1A gene is involved in multiple biological pathways and processes, including but not limited to:
- **TGF-beta signaling:** FKBP1A keeps the TGFBR1 in an inactive conformation in the absence of ligand, preventing unwanted receptor activation.
- **Calcium signaling pathways:** Contributing to the modulation of calcium channels (e.g., RYR1), affecting muscle contraction and signaling.
- **Protein folding and quality control:** Functioning as a chaperone and facilitating protein maturation, critical in various cellular processes.

### Summary
FKBP1A is a multifaceted gene with key roles in calcium signaling, TGF-beta signaling, and protein homeostasis. Its interactions with specific drugs highlight its significance in clinical contexts, while its connections to aging and cardiovascular disease underscore its importance in health and disease across the lifespan.