### Overview of the KDM1A Gene

**Gene Symbol:** KDM1A  
**Function:** The KDM1A gene encodes a histone demethylase enzyme that plays a critical role in the regulation of gene expression through the modification of histones. It contains several important protein domains including a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. KDM1A demethylates specific lysine residues on histone H3 (H3K4 and H3K9), acting as either a coactivator or a corepressor depending on the cellular context. 

**Protein Activity:** 
- **Demethylation of Histones:** KDM1A can demethylate mono- and di-methylated H3K4 (H3K4me1, H3K4me2) and di-methylated H3K9. 
- **Interplays with Other Proteins:** Functions with the corepressor complex RCOR1/CoREST to demethylate H3K4me on nucleosomes.
- **Role in Transcription Regulation:** Acts as a coactivator for androgen receptor-dependent transcription by mediating demethylation of H3K9me, which is linked to transcriptional repression contexts.

### 1. Associated Genes
While specific genes that directly interact with KDM1A are not fully exhaustive, the following genes and factors are known to have significant relationships with KDM1A:
- **RCOR1 (REST Corepressor 1):** A critical component for KDM1A demethylation activity on nucleosomes.
- **DNMT1 (DNA Methyltransferase 1):** Interacts with KDM1A to regulate DNA methylation status.
- **TP53 (Tumor Protein p53):** KDM1A demethylates p53 at specific lysines, impacting its regulation and activity.
- **SOX2 (SRY-Box Transcription Factor 2):** Methylation states on SOX2 are also modulated by KDM1A, affecting stem cell pluripotency.

### 2. Aging and Age-Related Diseases
KDM1A has been implicated in various aspects of aging and age-related diseases:
- **Cellular Senescence:** KDM1A's role in regulating gene expression and histone methylation may influence cellular aging, impacting processes such as senescence.
- **Cancer:** Dysregulation of KDM1A has been observed in various cancers, where overexpression can facilitate oncogenesis through the repression of tumor suppressor genes.
- **Neurodegenerative Diseases:** Its role in neuronal gene repression may associate KDM1A with the pathogenesis of age-related neurodegenerative diseases.

### 3. Drug Interactions
Several drug classes and compounds have been reported to interact with KDM1A:
- **Histone Demethylase Inhibitors:** Small molecule inhibitors designed to target KDM1A, such as those developed for clinical use in cancer therapy (e.g., LYS6).
- **Anticancer agents:** Drugs that perturb histone modifications or engage epigenetic reprogramming, indirectly affecting KDM1A functionality.
- **Hormonal Therapies:** Agents that target androgen receptor signaling may also influence KDM1A activity due to its role in AR-mediated transcription.

### 4. Pathways and Biological Processes
KDM1A is involved in several critical pathways and biological processes:
- **Epigenetic Regulation:** KDM1A plays a pivotal role in modifying chromatin structure, which influences transcriptional activation and silencing.
- **Gastrulation:** Essential for embryonic development and the regulation of key developmental transcription factors.
- **Hematopoiesis:** Part of the RCOR/GFI/KDM1A/HDAC complex that influences blood cell development and lineage specification.
- **Cell Cycle Regulation:** Potential involvement in the control of cell proliferation and differentiation.

Overall, KDM1A’s dual roles in transcriptional activation and repression, as well as its regulatory control over various key signaling pathways, makes it a critical factor in normal development, aging, and disease processes.