### AURKBP1 Gene Overview

**Gene Symbol:** AURKBP1  
**Chromosomal Location:** Human chromosome 17  
**Function:** AURKBP1, or Aurora kinase B-binding protein 1, is primarily involved in cell cycle regulation, specifically during mitosis. It is believed to assist in the stabilization and regulation of Aurora kinase B, an important enzyme that controls chromosomal segregation and cytokinesis.

### 1. Associated Genes

While specific associations may not always be explicitly mentioned, AURKBP1 may interact and be functionally related to several other genes involved in the cell cycle and mitotic processes. Some of the genes that are often referenced within the context of AURKBP1 include:

- **AURKB** (Aurora kinase B): Directly functions with AURKBP1 in the modulation of cell cycle processes.
- **CENP-A** (Centromere protein A): Associated with chromosomal functions.
- **PLK1** (Polo-like kinase 1): Plays a role in cell division and is often intertwined with mitotic spindle assembly.

### 2. Aging and Age-Related Diseases

Currently, there is limited specific direct information linking AURKBP1 to aging or age-related diseases. However, Aurora kinases like AURKB are broadly implicated in various processes of cell division and could play indirect roles in age-related cellular processes, like the maintenance of genome integrity, cellular senescence, and the overall aging of tissues. Disruption in such processes can contribute to the development of age-related diseases, including cancer, as they affect the regulation of cell proliferation and apoptosis.

### 3. Drug Interactions

Aurora kinase inhibitors are a class of compounds known to interact with proteins like AURKBP1, given its role in modulating Aurora kinase B activity. Specific drugs targeting this pathway include:

- **ZM447439**: An Aurora kinase inhibitor known to interfere with the function of Aurora kinases, hence affecting AURKBP1 activity indirectly.
- **MK-0457** (also known as VX-689): Another small-molecule inhibitor targeting Aurora kinases.

These drugs are mainly under research for their roles in cancer therapy, as aberrations in these pathways often lead to tumorigenesis.

### 4. Pathways and Biological Processes

AURKBP1 is involved in several important biological pathways and processes:

- **Cell Cycle Regulation:** Particularly during the M phase, where it influences processes related to mitosis.
- **Chromosome Segregation:** It helps in the proper alignment and separation of chromosomes during cell division, thereby contributing to genomic stability.
- **Cytokinesis:** AURKBP1 aids in the final separation of daughter cells after mitosis.
- **Signal Transduction Pathways:** Some studies suggest involvement in pathways related to cellular signaling mechanisms during mitosis.

This involvement in crucial pathways underscores its potential significance in both normal cell biology and disease contexts. Given emerging insights into cellular aging, ongoing research may further delineate how AURKBP1 influences aging and cellular senescence processes.