### DLG3 Gene Overview

**Gene Symbol**: DLG3  
**Location**: Xq27.1 (X chromosome)  
**Gene Type**: Protein-coding gene  
**Protein**: Discs large homolog 3 (DLG3)  

DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) family, primarily involved in the regulation of synaptic transmission and plasticity, particularly at excitatory synapses, where it plays a critical role in clustering NMDA receptors. It is also connected to cellular signaling pathways and may act as a tumor suppressor by interacting with the adenomatous polyposis coli (APC) protein.

### 1. Associated Genes
DLG3 has been shown to interact with and be associated with several other genes, including:
- **GRIN2B**: Involved in NMDA receptor signaling.
- **APC**: Involved in Wnt signaling and cellular proliferation.
- **SHANK3**: Crucial for synaptic function and implicated in neurodevelopmental disorders.
- **PSD95**: A key protein in post-synaptic density and synaptic signaling.
- **NF1**: Associated with neurofibromatosis, playing a role in neuronal signaling pathways.

### 2. Aging and Age-Related Diseases
While specific studies targeting DLG3 in the context of aging are limited, its role in synaptic plasticity and cognitive function suggests that it may have implications for age-related cognitive decline and disorders such as Alzheimer's disease. Altered NMDA receptor signaling and synaptic dysfunction are well-established features of cognitive decline associated with aging. Variants in DLG3 may contribute to the risk of age-related cognitive dysfunction, although more research is needed in this area.

### 3. Known Drug Interactions
Currently, there are no specific drugs that directly interact with DLG3 in well-documented pharmacological databases. However, given its role in NMDA receptor signaling, it could theoretically be influenced by drugs targeting NMDA receptors, such as:
- **Glutamate receptor modulators**: Drugs that modulate NMDA receptor activity.
- **Antipsychotic medications**: Some act on glutamatergic systems and might affect synaptic pathways involving DLG3.

### 4. Pathways and Biological Processes
DLG3 is involved in several important biological processes:
- **Cell Signaling**: Participates in receptor signaling pathways, including those involving NMDA receptors.
- **Synaptic Plasticity**: Critical for mechanisms underlying memory and learning, particularly through synaptic strengthening or weakening processes.
- **Cell Proliferation Regulation**: May negatively regulate proliferation via APC interactions, linking it to tumor biology.
- **Neurodevelopment**: Plays a role in neuronal differentiation and organization during development.

### Conclusion
The DLG3 gene is essential for proper synaptic function and cognitive processes. Its interactions, potential pathways, and roles in neurodevelopment and proliferation underscore its significance in both normal biology and disease states. Further research is warranted to elucidate its role in aging and neurodegenerative conditions.