### CDC14C Gene Overview

**Gene Symbol:** CDC14C  
**Chromosomal Location:** Chromosome 9

The CDC14C gene is a retrogene derived from the CDC14B gene. It has undergone a process that removed introns from its coding sequence. While it shares a common ancestry with CDC14B, CDC14C has a truncated open reading frame, which results in the absence of certain N-terminal sequences, including a nuclear localization signal. This modification contributes to a distinct subcellular localization pattern: CDC14C localizes to the endoplasmic reticulum (ER) instead of displaying microtubular localization like its parental gene product, suggesting a potential new functional role in cellular physiology.

**Protein Function:** CDC14C encodes a dual-specificity phosphatase, primarily known for preferentially dephosphorylating proteins that are modified by proline-directed kinases.

### Additional Information

1. **Associated Genes:**
   - **CDC14A and CDC14B:** These are its direct homologs and are involved in cell cycle regulation. They share common roles in dephosphorylation processes and are part of the larger CDC14 family of phosphatases.
   - **Other genes:** While the NCBI and UniProt summaries do not specify additional genes, other cell cycle-related genes such as those involved in the mitotic spindle could potentially be associated due to shared biological pathways.

2. **Aging and Age-Related Diseases:**
   - Although specific age-related associations are not well characterized in widely available literature, CDC14 family members have been implicated in processes that influence cell cycle regulation and apoptosis. Dysregulation of cell cycle proteins is a common feature in aging and age-related diseases, including cancer. Future research may elucidate direct connections between CDC14C and age-related cellular processes.

3. **Drug Interactions:**
   - As of the latest data, specific drugs or drug classes that interact directly with CDC14C have not been well-documented. However, given its role in phosphatase activity, drugs targeting phosphorylation pathways or kinase inhibitors (e.g., targeted cancer therapies that inhibit proline-directed kinases) may indirectly influence the action of CDC14C.

4. **Pathways and Biological Processes:**
   - **Cell Cycle Regulation:** As a member of the CDC14 family, CDC14C is involved in regulating various stages of the cell cycle.
   - **Protein Dephosphorylation:** Its dual-specificity phosphatase activity allows it to remove phosphate groups from proteins, particularly those modified by proline-directed kinases.
   - **Endoplasmic Reticulum Stress Response:** Given its localization, CDC14C may play a role in the ER stress response and may be involved in maintaining cellular homeostasis under stress conditions.
   - **Potential Role in Cellular Signaling:** The dephosphorylation activity could downregulate signaling pathways, influencing processes such as apoptosis or cell differentiation.

### Conclusion

The CDC14C gene represents an interesting evolution of the CDC14 family, with modifications that suggest novel functions—particularly in the context of the endoplasmic reticulum. Its potential implications in aging, disease, and therapeutic interactions offer avenues for further research and clinical exploration.