### WDR82 Gene Overview

**Gene Symbol**: WDR82  
**Location**: Chromosome 12 (12q24.31)  
**Gene Type**: Protein-coding  

**Protein Summary**: WDR82 is a regulatory component of the SET1 complex, implicated in chromatin remodeling and transcription regulation. It plays a key role in histone modification, particularly through histone H3 'Lys-4' methylation (H3K4me), facilitating the recruitment of SETD1A or SETD1B to actively transcribing gene loci. This process is critical for gene expression as it ensures the appropriate modification of histones, affecting DNA accessibility and transcription factor recruitment. WDR82 is also a component of the PTW/PP1 phosphatase complex, which is involved in chromatin structure control and cell cycle regulation, especially during the transition from mitosis to interphase. Additionally, WDR82 collaborates with ZC3H4 in a transcription termination checkpoint that influences the degradation of long non-coding RNAs (lncRNAs) through the exosome complex.

### Association with Other Genes

1. **SETD1A** - Histone methyltransferase, recruits to sites of active transcription.
2. **SETD1B** - Another histone methyltransferase implicated in gene regulation.
3. **ZC3H4** - Component of the transcription termination checkpoint for lncRNAs.
4. **POLR2A** - The large subunit of RNA polymerase II, which is crucial for mRNA synthesis.

### Details Related to Aging or Age-Related Diseases

- While specific direct associations of WDR82 with aging or particular age-related diseases are not extensively documented, its role in chromatin remodeling and transcriptional regulation suggests a potential influence on cellular senescence and age-related transcriptional dysregulation.
- Dysregulation of gene expression due to aberrant histone modifications (like H3K4me) can be linked to various age-related disorders, including cancer and neurodegenerative diseases.
- Further studies might explore WDR82's potential contribution to cellular aging processes, but concrete findings are still developing.

### Drug Interactions

- Currently, specific drugs or drug classes that directly interact with the WDR82 gene are not well-defined in the literature. However, drugs that target epigenetic modifications (e.g., histone deacetylase inhibitors, and histone methyltransferase inhibitors) may indirectly influence the activity of pathways involving WDR82.
- Additionally, some cancer therapeutics that affect transcriptional machinery might influence expression or function related to WDR82.

### Pathways and Biological Processes

1. **Transcription Termination** - Involvement in the checkpoint that facilitates transcription termination of lncRNAs.
2. **Chromatin Remodeling** - Key role in regulating chromatin structure, influencing gene expression.
3. **Cell Cycle Control** - Participates in transitions from mitosis to interphase.
4. **Histone Methylation** - Mediates H3K4 methylation, a mark of active transcription.
5. **RNA Polymerase II Transcription Activation** - Recruitment to actively transcribing genes.

WDR82 is an important gene referring to mechanisms that underlie transcriptional control and chromatin dynamics. Ongoing research may reveal more about its role in health, disease, and aging.