### CETN3 Gene Overview

**Gene Symbol**: CETN3  
**Location**: Chromosome 16q24.3  
**Protein**: Calcium-binding protein, involved in microtubule organizing center structure and function.

#### 1. Associated Genes
CETN3 has been associated with several other genes involved in cellular processes, particularly those related to the centrosome and microtubule functions. Some of these include:

- **CETN1 and CETN2**: Other members of the centrin family involved in similar structural and regulatory roles at the centrosome.
- **CDK5**: A serine/threonine kinase that may interact with centrins in the context of cell cycle regulation.
- **TPX2**: A protein that assists in microtubule organization and spindle assembly, which might interact with centrin proteins during cell division.
- **TUBG1**: A gamma-tubulin protein that plays a critical role in microtubule nucleation and has been associated with centrosomal functions.

#### 2. Aging and Age-related Diseases
While there is limited direct evidence specifically linking CETN3 to aging or age-related diseases, centrins, including CETN3, are essential for proper spindle formation and chromosome segregation. Dysregulation of these processes can lead to age-related cellular dysfunctions and may be implicated in conditions such as cancer. Some studies suggest that alterations in centrosome structure and function can contribute to aging by affecting cell division and genomic stability.

#### 3. Drug Interactions
There are currently no specific drugs known to target CETN3 directly. However, potential drug classes that could affect the function of centrins or indirectly modulate CETN3 activity may include:

- **Antitubulin agents**: Such as Paclitaxel and Vincristine, which disrupt microtubule dynamics and may influence centrin functions indirectly.
- **Kinase inhibitors**: Agents that target kinases involved in cell cycle regulation and centrosome function may also be relevant due to regulatory interactions with centrin proteins.

#### 4. Pathways and Biological Processes
CETN3 is involved in several important biological pathways and processes, including:

- **Cell Cycle Regulation**: Plays a crucial role in the duplication and separation of centrosomes, which are vital for proper mitosis.
- **Microtubule Organization**: Functions in the organization of microtubules, influencing mitotic spindle assembly.
- **Ciliary Organization**: Centrin proteins, including CETN3, are often involved in the formation and maintenance of cilia, which are important for various signaling pathways.
- **Calcium Signaling Pathways**: Given its EF-hand calcium-binding domains, CETN3 may play a role in calcium signaling cascades within cells impacting various physiological responses.

Overall, CETN3 is a critical player in cellular processes associated with the centrosome, microtubule organization, and potentially in the maintenance of genomic stability, which could have implications in age-related cellular dysfunctions. Further studies would be necessary to explore its full range of interactions and implications in health and disease.