### RNA5SP387 Gene Overview

**Gene Symbol:** RNA5SP387

RNA5SP387 is classified within the family of small nucleolar RNAs (snoRNAs), particularly within the H/ACA box snoRNA class. These snoRNAs are primarily involved in the biogenesis and modification of ribosomal RNA (rRNA) and other RNA molecules through pseudouridylation and methylation.

### 1. Associated Genes

While specific genes directly associated with RNA5SP387 may not be explicitly listed in NCBI and UniProt summaries, snoRNAs often have functional associations with genes involved in ribosome biogenesis and RNA modification. Some potential associated genes within the context of human biology might include:

- **FBL (Fibrillarin)**: Involved in the modification of rRNA, to which snoRNAs like RNA5SP387 contribute.
- **NOP10**: Another snoRNP component involved in rRNA modification processes.
  
### 2. Aging and Age-Related Diseases

To date, specific studies directly associating RNA5SP387 with aging or age-related diseases are limited, but there are general themes in the literature surrounding snoRNAs and their potential roles in cellular aging:

- **Alterations in snoRNA expression**: Changes in the expression levels of various snoRNAs, including potentially RNA5SP387, have been linked with age-related declines in ribosome biogenesis and increases in cellular senescence.
- **Cellular stress response**: Some studies indicate that the dysregulation of snoRNAs may correlate with stress responses related to age-related diseases, though this remains an active area of research.

### 3. Drug Interactions

As of the latest information up to October 2023, there are no specific drugs or drug classes known to interact directly with the RNA5SP387 gene. However, it is important to understand that snoRNAs do play subsidiary roles in cellular processes, which may be indirectly affected by drugs targeting pathways involved in RNA processing or ribosomal function. 

### 4. Pathways and Biological Processes

RNA5SP387 is involved in several biological processes, primarily:

- **Ribosome biogenesis**: It is essential for the processing and modification of rRNA, contributing to the assembly of ribosomal subunits.
- **rRNA pseudouridylation**: RNA5SP387, like other H/ACA box snoRNAs, is involved in the specific modification of ribosomal RNA, which is crucial for ribosome function.
- **RNA modification**: Beyond rRNA, snoRNAs also participate in other forms of RNA modification processes.

### Conclusion

Understanding the role of RNA5SP387 within the broader context of cellular function and gene regulation is crucial, particularly as research continues to elucidate how non-coding RNAs like snoRNAs contribute to cellular aging and overall organism health. The potential for interactions with pathways linked to disease could present new avenues for exploring therapeutic targets in age-related conditions.