### RABGAP1L Gene Overview

**Gene Symbol:** RABGAP1L  
**Chromosomal Location:** The RABGAP1L gene is located on human chromosome 1.  

### Functional Roles
RABGAP1L is primarily known for its role as a GTPase-activating protein (GAP) for the small GTPase RAB22A. By converting the active RAB22A-GTP to its inactive form, RAB22A-GDP, RABGAP1L regulates intracellular processes, particularly endocytosis and protein localization. The gene is involved in:

- **GTPase Activator Activity:** RABGAP1L facilitates the hydrolysis of GTP bound to RAB22A.
- **Small GTPase Binding Activity:** It binds to and modulates the activity of small GTPases.
- **Protein Localization Regulation:** It influences the positioning of proteins within cells.

### Cellular Localization
RABGAP1L is found in:
- Golgi apparatus
- Early endosome
- Nucleus

### Interactions
RABGAP1L is recruited to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes by the protein ANK2. It is part of the ANK2/RABGAP1L complex, which is essential for the polarized recycling of fibronectin receptors (ITGA5 and ITGB1) to the plasma membrane, supporting directional cell migration.

### Associated Genes
While specific additional genes associated with RABGAP1L were not mentioned in the summary provided, its interactions with proteins such as ANK2 and RAB22A are crucial for its function. Further exploration in gene association databases may reveal connections with other genes involved in cellular transport and migration.

### Age-Related Insights
While the summaries provided do not include direct references to aging or age-related diseases, the role of RABGAP1L in cellular localization and trafficking of receptors such as ITGA5 and ITGB1 could suggest implications in age-related processes. Alterations in cellular trafficking often accompany aging, potentially affecting stem cell function, tissue regeneration, and the pathology of age-related diseases (such as cancer and neurodegenerative diseases).

### Drug Interactions
Currently, there are no specific drugs or drug classes listed in the literature directly interacting with RABGAP1L. However, given its role in cellular signaling and transport, it may be pertinent to explore inhibitors of RAB GTPases or modulators of endocytosis for therapeutic avenues that may indirectly involve RABGAP1L.

### Pathways and Biological Processes
RABGAP1L is involved in several biological pathways, including:

- **Endocytosis:** Involved in the internalization of membrane proteins, affecting nutrient uptake and receptor recycling.
- **Intracellular Protein Transport:** Facilitates the movement of proteins to the appropriate cellular locations, impacting signaling pathways and cellular function.
- **Cell Migration:** By promoting the recycling of receptors crucial for cell motility, RABGAP1L plays a significant role in processes such as wound healing and immune response.

For more detailed information, research into specific protein-protein interactions, and current studies regarding RABGAP1L may offer additional insights, particularly in the context of its potential roles in disease mechanisms and therapeutic strategies.