### Summary of NUSAP1 Gene

**Gene Symbol:** NUSAP1  
**Function:** The NUSAP1 gene encodes a microtubule-associated protein involved in the stabilization and bundling of microtubules. It also has a role in the organization of the mitotic spindle during cell division, which is critical for proper chromosome segregation.

### 1. Associated Genes
NUSAP1 is linked to several other genes, particularly those involved in cell division, microtubule organization, and cancer biology. Some associated genes include:
- **TPX2:** Involved in microtubule organization and spindle assembly.
- **Aurora Kinases (AURKA, AURKB, AURKC):** Key regulators of the mitotic process.
- **CENP-E (Centromere-associated protein E):** Important for chromosome alignment and segregation.
- **KIF2C (Kinesin Family Member 2C):** A motor protein involved in the movement of chromosomes.

### 2. Aging and Age-related Diseases
While specific aging-related studies directly linking NUSAP1 to aging processes are limited, its involvement in cell division and microtubule dynamics suggests potential implications in:
- **Cancer:** Alterations in NUSAP1 expression or function may contribute to cancer progression, which is often associated with aging.
- **Cellular Senescence:** Disruption in microtubule integrity can influence cellular aging and senescence, possibly implicating NUSAP1 in aging-related cellular changes.

### 3. Drug Interactions
Currently, there are no specific drugs or drug classes widely recognized for direct interaction with NUSAP1. However, the following categories may have indirect effects:
- **Antineoplastic Agents:** Drugs targeting microtubules such as taxanes (e.g., Paclitaxel) or vinca alkaloids can indirectly influence the pathways where NUSAP1 is active due to its role in stabilizing microtubules.
- **Small Molecule Inhibitors:** Compounds that affect microtubule dynamics or modulate the functions of associated proteins in the spindle apparatus may also impact NUSAP1 activity.

### 4. Pathways and Biological Processes
NUSAP1 is involved in several key biological pathways and processes, including but not limited to:
- **Mitosis:** Vital for proper cell division and ensuring accurate chromosome segregation.
- **Microtubule Organization:** Contributes to the assembly and stability of microtubules.
- **Cell Cycle Regulation:** Plays a role in cells progressing through various phases of the cell cycle, particularly during mitosis.
- **Cytoskeleton Dynamics:** Involved in maintaining cellular structure and function through interactions with microtubules.

In summary, NUSAP1 appears to play a significant role in cellular function and organization during mitosis, which may have implications in aging and cancer pathology. Research continues to better understand its complete biological roles and potential therapeutic targets.