### RBM45 Gene Overview

**Gene Symbol**: RBM45  
**Description**: RBM45 (RNA Binding Motif Protein 45) encodes a member of the RNA recognition motif (RRM)-type RNA-binding protein family. It is involved in the regulation of RNA metabolism and exhibits preferential binding to poly(C) RNA.

#### 1. Associated Genes
While specific associations with other genes can vary based on studies, RBM45 has been implicated in several pathways and may interact with genes involved in neurodegenerative diseases and RNA processing. Potentially related genes include:
- **TDP-43**: TAR DNA-binding protein 43, which plays a role in neurodegenerative conditions like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
- **FUS**: Fused in sarcoma, another RNA-binding protein involved in similar diseases.
- **SOD1**: Superoxide dismutase 1, which is linked to familial ALS.
- **MAPT**: Microtubule-associated protein tau, involved in Alzheimer's disease.

#### 2. Aging and Age-Related Diseases
RBM45 has been localized to inclusion bodies in the brains and spinal cords of patients with amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. This suggests a potential role in the pathology of age-related neurodegenerative diseases, possibly through its involvement in RNA processing and mis-splicing mechanisms that are often observed in aging. In experiments, increased levels of RBM45 have been correlated with certain dysfunctions in neural-specific RNA binding under stress conditions, which may also be relevant in the context of aging and the maintenance of neural tissue function.

#### 3. Drug Interactions
As of the latest information, there are no specific drugs or drug classes directly linked to the RBM45 gene in terms of pharmacological targeting. However, the proteins and pathways RBM45 is associated with, especially in neurodegenerative contexts, may be impacted by medications or treatments aimed at modifying RNA metabolism or reducing neuroinflammation (e.g., neuroprotective agents or RNA-targeted therapies).

#### 4. Pathways and Biological Processes
RBM45 is involved in several biological processes, including:
- **Molecular Function**: RNA binding, specifically to poly(C) RNA.
- **Cellular Component**: It is primarily localized in the nucleus, and its presence in inclusion bodies in affected neural tissues indicates a potential role in abnormal RNA processing in degenerative contexts.
- **Biological Processes**: It participates in processes such as:
  - RNA splicing regulation.
  - RNA stability and localization.
  - Neural development and differentiation.
  
Additionally, RBM45 may also be engaged in cellular stress responses, which can be crucial in the context of neurodegeneration and aging.

### Summary
Overall, RBM45 plays a significant role in RNA metabolism, particularly in neural tissues. Its association with age-related diseases like Alzheimer's and ALS, as well as other RNA-binding proteins, signals its potential importance in understanding the molecular underpinnings of neurodegeneration and age-related neural dysfunction. Further studies are necessary to fully elucidate its role and potential therapeutic implications.