**ZFP91 Gene Overview**

- **Gene Symbol**: ZFP91 
- **Protein**: Zinc finger protein 91 
- **Function**: ZFP91 is a member of the zinc finger family of proteins characterized by C2H2-type zinc finger domains. It acts as a regulator of the non-canonical NF-kappaB (NF-κB) signaling pathway, particularly in lymphotoxin-beta receptor signaling, through its role as an atypical E3 ubiquitin-protein ligase that contributes to the 'Lys-63'-linked ubiquitination of MAP3K14/NIK, promoting its stability and activation.

### 1. Associated Genes
While the summaries provided focus on ZFP91 without citing specific interacting genes, ZFP91 is known to have interactions with:
- **MAP3K14 (also known as NIK)**: Target of ZFP91's ubiquitination effects.
- **NFKB2**: A downstream effector in the non-canonical NF-kB signaling pathway.
- **CNTF**: The downstream gene mentioned in the context of read-through transcription.

### 2. Aging and Age-Related Diseases
Research directly linking ZFP91 to aging or specific age-related diseases is limited. However, as ZFP91 influences the NF-kB signaling pathway, which is often implicated in inflammatory responses and cellular stress—a contributor to age-related diseases such as cancer, neurodegeneration, and cardiovascular diseases—there may be indirect associations worth further exploration. Dysregulation of NF-kB has been observed in various aging processes and age-related changes in cellular function, suggesting a potential role for ZFP91 in these contexts.

### 3. Drug and Drug Class Interactions
Specific drugs or drug classes directly interacting with ZFP91 may not be well-characterized. However, compounds affecting the NF-kB pathway (including proteasome inhibitors and various anti-inflammatory drugs) could theoretically modulate ZFP91 functions. These include:
- **Proteasome inhibitors**: These affect pathways involving ubiquitination.
- **NF-kB inhibitors**: Such as pyrrolidine dithiocarbamate (PDTC) or specific IKK inhibitors that could influence the downstream NF-kB signaling regulated by ZFP91.

Future studies may provide concrete pharmacological links.

### 4. Pathways and Biological Processes
ZFP91 is involved in several key biological pathways and processes:
- **Non-canonical NF-kB signaling pathway**
- **Signal transduction**: Particularly concerning lymphotoxin-beta receptor signaling.
- **Regulation of apoptosis**: Influencing cell survival and proliferation.
- **Ubiquitination**: As an E3 ligase, it mediates the modification of substrates for proteasomal degradation or functional stabilization.

In summary, ZFP91 serves vital roles in regulating immune responses and may influence cellular homeostasis and signaling within contexts that could link to wider biological implications, including aging and disease. Continued research will likely elucidate further associations and mechanisms of action.