### Overview of CASK-AS1 Gene

**Gene Symbol:** CASK-AS1  
**Gene Type:** Long non-coding RNA (lncRNA)  
**Description:** CASK-AS1 (CASK antisense RNA 1) is a long non-coding RNA that is known for its role in various biological processes, including gene regulation. It is located in the vicinity of the CASK gene, which encodes a protein involved in synaptic functioning and neuronal signaling.

### 1. Associated Genes
While the summaries provided by NCBI and UniProt may list specific genes, additional associations can include:
- **CASK (Calcium/calmodulin-dependent serine protein kinase):** The protein that CASK-AS1 is closely associated with and may regulate through antisense mechanisms.
- **Other nearby lncRNAs and protein-coding genes:** There may be intergenic influences and regulatory interactions with other genes located on chromosome 17, but specific interactions need to be further characterized through current literature.

### 2. Aging and Age-Related Diseases
Research indicates that long non-coding RNAs like CASK-AS1 may play roles in aging and age-related diseases. Some relevant points include:
- **Regulatory Role in Aging:** Long non-coding RNAs are involved in regulating genes associated with cellular senescence, which could implicate CASK-AS1 in the aging process.
- **Associations with Neurodegenerative Disorders:** Given that CASK is linked to neuronal functions, CASK-AS1 may indirectly influence pathways related to age-related diseases such as Alzheimer's and other neurodegenerative diseases through its regulatory effects.

### 3. Drug Interactions
Currently, there is limited information regarding direct drug interactions with CASK-AS1. However, lncRNAs can influence the efficacy of certain drugs indirectly through regulatory networks. Some potential drug classes could include:
- **Antineoplastic agents:** Since some evidence suggests lncRNAs may be implicated in cancer pathways, CASK-AS1 might play a role in modulating responses to cancer therapies.
- **Neuroprotective drugs:** If CASK-AS1 is involved in neurodegenerative processes, substances aimed at protecting neurons may relate to its expression changes.

### 4. Pathways and Biological Processes
CASK-AS1 has been implicated in several important biological processes, although detailed pathways specifically highlighting this lncRNA are still being elucidated. Some known pathways include:
- **Neuronal Signaling:** Interaction and modulation of gene expression related to synaptic activity and neural development due to its association with the CASK gene.
- **Gene Regulation:** Acting primarily in a regulatory capacity, influencing chromatin remodeling and transcriptional processes.
- **Cellular Proliferation and Apoptosis:** Involvement in pathways that regulate these fundamental processes, possibly influencing development and responses to stress or damage.

### Conclusion
The CASK-AS1 gene is a long non-coding RNA with a role in gene regulation, particularly in neuronal contexts. As research progresses, our understanding of its associations with other genes, its implications in aging and diseases, and interactions with pharmacological agents will continue to evolve, necessitating continual updates from scientific literature.