### IDH1-AS1 Gene Summary

**Gene Symbol:** IDH1-AS1  
**Gene Description:** IDH1-AS1 is a long non-coding RNA (lncRNA) that is associated with the regulation of gene expression. It is situated near the IDH1 gene, which encodes an enzyme involved in the metabolism of isocitrate to alpha-ketoglutarate. While IDH1-AS1 does not code for a protein, its expression can influence the transcriptional activity of nearby genes.

### 1. Associated Genes
In addition to the IDH1 gene, IDH1-AS1 has been implicated in the regulation of several other genes and molecular pathways. Though specific additional genes directly associated with IDH1-AS1 may not be well-documented, it's common for lncRNAs to interact with various transcription factors, chromatin remodeling complexes, and signaling pathways. Some candidates based on its expression profile may include:
- **IDH2:** Similar to IDH1, it also encodes isocitrate dehydrogenase and is relevant in metabolic pathways.
- **TP53:** The tumor suppressor gene may interact indirectly due to the cancer-related roles of IDH1 and encoding RNAs like IDH1-AS1.
- **AKT1:** Involved in cellular metabolism and survival pathways, which could be affected by lncRNA expression.

### 2. Aging and Age-Related Diseases
Research indicates a potential role for IDH1-AS1 in age-related diseases, particularly in oncology:
- **Cancer:** LncRNAs like IDH1-AS1 have been implicated in tumorigenesis. Alterations in lncRNA expression profiles have been associated with various cancers, such as glioma and acute myeloid leukemia (AML). IDH1, in particular, is frequently mutated in gliomas, affecting cell metabolism and signaling pathways critical for both tumor initiation and progression.
- **Neurological Disorders:** Given its relation to IDH1 and the importance of metabolic processes in brain aging, dysregulation of IDH1-AS1 might contribute to age-related neurodegenerative conditions.

### 3. Drug Interactions 
Currently, there are no specific drugs or drug classes directly interacting with IDH1-AS1, given its classification as a long non-coding RNA. Nevertheless, mutations in IDH1 have led to the development of targeted therapies in cancers, like:
- **IDH Inhibitors (e.g., Ivosidenib, Enasidenib):** These small molecules specifically inhibit mutant IDH1/IDH2 enzymes and may indirectly relate to lncRNA expressions like IDH1-AS1 in therapeutic contexts.
- **General anticancer drugs:** The overall regulatory pathways affected by lncRNAs can influence the responsiveness of cancer treatments, though IDH1-AS1 isn't a direct target.

### 4. Pathways and Biological Processes
IDH1-AS1 is involved in various biological processes and pathways:
- **Regulation of Gene Expression:** As a lncRNA, IDH1-AS1 likely has a role in chromatin remodeling and transcriptional regulation of associated genes.
- **Metabolic Pathways:** Directing effects on the metabolism related to the IDH1/IDH2 pathway implicates it in key metabolic processes like the citric acid cycle.
- **Cell Growth and Proliferation:** Due to its association with tumor-related processes, IDH1-AS1 likely participates in signaling pathways important for cellular proliferation and survival.
- **Tumorigenesis:** Its role in modulating cancer-associated genes makes it a potential player in tumor development and progression.

In summary, IDH1-AS1 plays a significant role as a long non-coding RNA with regulatory functions likely tied to cancer development and related metabolic pathways. Further studies are needed to elucidate its full spectrum of interactions and implications in aging and disease.