The NEPRO gene, also referred to as "Neprilysin-related protein," is primarily associated with neuronal differentiation and the Notch signaling pathway, as you noted. Here’s a more detailed overview, including the requested additional information:

### 1. Other Genes Associated with NEPRO
While specific genes directly co-regulated or functionally linked to NEPRO might not be widely documented, several pathways and biological processes involving Notch signaling inherently suggest interactions with key genes, such as:
- **NOTCH1**: Plays a critical role in the Notch signaling pathway and neuronal differentiation.
- **HES1**: A transcription factor that is targetable by Notch signaling, involved in maintaining progenitor cells.
- **DLL1**: A ligand for the Notch receptor, contributing to signal activation and cellular communication in development.
- Other proneural genes, which NEPRO is predicted to repress.

### 2. Age and Age-related Diseases
While specific studies explicitly linking NEPRO to aging or age-related diseases may be limited, its role in neuronal differentiation implies potential connections to neurodegenerative conditions. Age-related diseases, such as Alzheimer’s disease, could benefit from understanding NEPRO's function in neural progenitor maintenance and differentiation. As interactions might exist between Notch signaling and the aging process, NEPRO could be implicated in diseases where neurogenesis and neural maintenance become dysregulated with age.

### 3. Drug Interactions
Currently, there is no widely documented or specific class of drugs that target NEPRO directly. However, since the protein is involved in the Notch signaling pathway, drugs that modulate this pathway might indirectly affect NEPRO activity:
- **Notch Pathway Modulators**: 
  - Gamma-secretase inhibitors (like **DAPT**) used in the context of cancer therapies or Alzheimer’s disease could influence the pathway's dynamics, potentially affecting NEPRO's activity.
  
### 4. Pathways and Biological Processes
NEPRO is involved in several key biological processes and pathways:
- **Notch Signaling Pathway**: Central for cell fate determination, especially in the regulation of neural progenitor cells.
- **Neurogenesis**: Maintains a balance between neuronal progenitor cell cycling and differentiation to neurons.
- **Embryonic Development**: Particularly in regulating early stages of development in pre-implantation embryos.
- **Negative Regulation of Neuron Differentiation**: Via repression of proneural genes, it is crucial for sustaining the neural progenitor pool.

In conclusion, NEPRO plays a vital role in multiple regulatory pathways associated with neural development and differentiation, and potential links to aging and age-related disorders could open avenues for further research. Understanding interactions with other genes and signaling pathways may also unveil its broader implications in health and disease.