### ASPSCR1 Gene Overview

**Gene Symbol:** ASPSCR1  
**Location:** Chromosome 17 (17q25)  
**Protein Product:** The protein encoded by the ASPSCR1 gene is known to contain a UBX domain, which facilitates interactions with other proteins, specifically the glucose transporter GLUT4. 

### 1. Associated Genes
The ASPSCR1 gene is primarily noted for its interaction with the glucose transporter type 4 (GLUT4) and the TFE3 transcription factor, particularly in the context of the fusion protein formed in specific cancers. While the summaries mention ASPSCR1 and TFE3, other relevant genes may include those involved in metabolic processes and signal transduction, including:
- **GLUT4 (SLC2A4):** Directly interacts with ASPSCR1 for glucose transport regulation.
- **VCP (Valosin-Containing Protein):** Involved in protein degradation and also interacts with ASPSCR1.
- **Various signaling molecules:** ASPSCR1 participates in insulin signaling pathways, which may involve other related genes such as IR (Insulin Receptor) and IRS (Insulin Receptor Substrate).

### 2. Aging and Age-Related Diseases
Research linking ASPSCR1 explicitly to aging or age-related diseases is currently limited. However, given its role in GLUT4 regulation and glucose metabolism, it could be inferred that dysfunctions in ASPSCR1 may contribute to insulin resistance, which is a significant risk factor for age-related conditions such as:
- Type 2 Diabetes: As aging progresses, decreased insulin sensitivity impacts glucose uptake, where ASPSCR1 may play a role.
- Obesity: Impaired GLUT4 translocation can contribute to increased fat accumulation, which is often more prevalent with age.
- Cardiovascular Diseases: Since insulin resistance is a precursor to several cardiovascular conditions, ASPSCR1 may be indirectly involved.

### 3. Drug Interactions
As ASPSCR1 itself is not a direct drug target, specific known drugs may not be indicated. However, therapeutics that affect glucose metabolism and insulin signaling may indirectly influence ASPSCR1 function, such as:
- **Insulin:** Modulates GLUT4 translocation, which ASPSCR1 is involved in.
- **Thiazolidinediones (e.g., Rosiglitazone, Pioglitazone):** Enhance insulin sensitivity, possibly impacting ASPSCR1's role.
- **Metformin:** Although primarily known for AMPK activation, it can influence GLUT4 pathways indirectly, thus affecting ASPSCR1's regulatory effect.

### 4. Pathways and Biological Processes
ASPSCR1 is implicated in several key metabolic and cellular processes, including:
- **Insulin Signaling Pathway:** Facilitates GLUT4 vesicle translocation to the plasma membrane following insulin stimulation.
- **GLUT4 Trafficking:** Sequestration and redistribution of GLUT4 containing vesicles in adipose and muscle tissues.
- **Protein Ubiquitination and Degradation:** Participation in the ubiquitin-proteasome pathway due to its interaction with VCP and the UBX domain facilitating protein complex activities.
- **Regulation of Methylation:** Involvement in the enhancement of VCP methylation by VCPKMT, highlighting a potential role in chromatin remodeling.

### Conclusion
The ASPSCR1 gene is crucial for the regulation of glucose uptake through its interaction with GLUT4 and plays potential roles in metabolic diseases, particularly those related to insulin signaling. Although direct links to aging are less established, its functions suggest a contributory role in age-related metabolic dysregulation. Further exploration could elucidate its relevance in both health and disease as individuals age.