### SNORD28 Gene Overview

The SNORD28 gene, also known as Small Nucleolar RNA, C/D Box 28, is a member of the C/D box small nucleolar RNA (snoRNA) family. snoRNAs play crucial roles in the biogenesis of ribosomal RNA (rRNA) and modification processes such as methylation and pseudouridylation. They primarily function through base-pairing with target rRNAs, guiding the modification enzymes to specific sites.

#### 1. Associated Genes

While specific associations with other genes may not be directly detailed in the NCBI and UniProt summaries, SNORD28 is generally associated with other snoRNAs in the C/D box family, such as:

- SNORD29
- SNORD30
- SNORD31

These snoRNAs can interact in regulatory networks and may have overlapping functions in rRNA modification.

#### 2. Aging and Age-Related Diseases

As a snoRNA, SNORD28 is involved in the regulation of rRNA processing and maturation, which is crucial for ribosome function and overall cellular health. While specific research may be limited regarding the direct role of SNORD28 in aging or age-related diseases, alterations in snoRNA expression have been implicated in processes related to:

- **Cellular senescence:** Dysregulation of ribosome biogenesis and modification has been observed in aging cells.
- **Cancer:** Aberrant snoRNA expression profiles, including members of the C/D box family, have been linked to various cancers due to their impact on cellular proliferation and survival.

There may also be associations with age-related conditions due to the fundamental role of snoRNAs in maintaining cellular function and integrity over time.

#### 3. Drug Interactions

Currently, there are no specific drugs or drug classes that are reported to directly interact with SNORD28. However, since snoRNAs like SNORD28 are involved in fundamental processes such as ribosome biogenesis, any agents that influence ribosomal function or RNA synthesis (e.g., antibiotics that target ribosomes) could indirectly affect the activity or expression of snoRNAs, including SNORD28.

#### 4. Pathways and Biological Processes

SNORD28 is involved in several key biological processes including:

- **Ribosome biogenesis:** SNORD28 plays a role in the modification of rRNA, essential for the formation of functional ribosomes.
- **RNA modification:** The primary function of SNORD28, as with other C/D box snoRNAs, involves guiding enzymes to specific sites on rRNA for 2'-O-methylation, contributing to the stability and functionality of the ribosome.
- **Gene expression regulation:** Through its role in rRNA modification, SNORD28 influences the overall protein synthesis capacity of the cell, impacting various cellular processes.

In summary, the SNORD28 gene is integral to the proper functioning of ribosomes through its role in rRNA modification. While direct links to aging or drug interactions are sparse, its overall involvement in ribosome biogenesis underpins many cellular processes that are crucial across the lifespan. Further research could elucidate more specific roles in aging and disease contexts.