### EEF1AKMT2 Gene Overview

- **Gene Symbol**: EEF1AKMT2
- **Function**: EEF1AKMT2 encodes a protein-lysine methyltransferase that is responsible for the trimethylation of the lysine residue at position 318 on the elongation factor 1-alpha (EEF1A). This methylation is significant for various cellular functions, including modulating protein interactions and stability.

### 1. Associated Genes

While EEF1AKMT2's primary focus is its interaction with EEF1A, other genes that may be related to its function or express in similar pathways could include:

- **EEF1A1 (Elongation Factor 1 Alpha 1)**: The primary substrate for EEF1AKMT2, involved in protein synthesis.
- **PRMT1 (Protein Arg Methyltransferase 1)**: Another methyltransferase that may work in tandem with lysine methylation processes.
- **NONO (Non-POU Domain Containing Octamer Binding Protein)**: Involved in RNA processing and possibly in association with EEF1A.

### 2. Aging and Age-Related Diseases

Research has suggested that methylation of lysines plays a significant role in various cellular processes, including gene expression, and cellular aging. Direct connections to age-related diseases that involve EEF1AKMT2 are less documented, but potential links may involve:

- **Alzheimer's disease and other neurodegenerative disorders**: Dysregulation of protein methylation has implications in protein aggregation and dysfunction in neurons, linked to age-related cognitive decline.
- **Cancer**: Abnormal methylation patterns, including those involving proteins like EEF1A, have been implicated in oncogenesis and tumor progression, with age being a significant risk factor for most cancers.

### 3. Drug Interactions

As of the latest data, specific drugs or drug classes directly targeting EEF1AKMT2 are not commonly discussed in literature. However, substances that may impact lysine methylation or overall epigenetic regulation could be of interest, including:

- **Histone deacetylase inhibitors (HDAC inhibitors)**: These drugs can influence the methylation landscape indirectly, which might involve EEF1AKMT2 activity.
- **Methyltransferase inhibitors**: Emerging compounds that inhibit protein methyltransferases are being investigated in cancer and may affect EEF1AKMT2 indirectly.

### 4. Pathways and Biological Processes

EEF1AKMT2 is involved in various biological processes and signaling pathways:

- **Protein Translation**: Its primary role affecting EEF1A directly links it to the translation elongation process during protein synthesis.
- **Regulation of Gene Expression**: By modifying EEF1A and potentially other substrates, EEF1AKMT2 plays a role in influencing transcriptional and translational control.
- **Cell Cycle Regulation**: Methylation processes involving EEF1A can affect cell cycle dynamics, potentially linking EEF1AKMT2 to processes associated with tumorigenesis and cell proliferation.
- **Response to Cellular Stress**: Methylation modifications may be involved in the cellular response to oxidative stress or other stressors, impacting aging processes.

### Summary

The EEF1AKMT2 gene plays a crucial role in post-translational modifications through lysine methylation, specifically targeting EEF1A. While there are connections to cellular aging and diseases, the broader implications of this gene in pharmacology and biological processes continue to be an area of active research. Further studies may elucidate its role in age-related mechanisms and potential therapeutic avenues.