### LYPLA2 Gene Summary

**Gene Symbol:** LYPLA2  
**Function:** The LYPLA2 gene encodes a member of the lysophospholipases family, which are involved in hydrolyzing lysophospholipids and acylating proteins. Specifically, it exhibits acyl-protein thioesterase activity, which removes fatty acids from S-acylated cysteine residues in proteins, influencing the function of these proteins, including signal transduction proteins.

### Additional Information

1. **Associated Genes:**
   - While the summaries provided primarily mention specific proteins and direct interactions, the broader context of LYPLA2 involvement may include associations with genes involved in lipid metabolism, signal transduction, and neurodegeneration. For instance:
     - **GAP43** (Growth-Associated Protein 43): Known for its role in neuronal growth.
     - **HRAS** (Harvey Rat Sarcoma Viral Oncogene Homolog): A member of the RAS gene family, involved in cell growth and differentiation.

2. **Aging and Age-Related Diseases:**
   - There is relatively limited specific data available on LYPLA2's connection to aging or age-related diseases. However, given its involvement in lipid metabolism and signal transduction pathways, potential implications might include:
     - **Neurodegenerative diseases:** Since LYPLA2 interacts with proteins relevant to neuronal function and signaling (e.g., GAP43), dysregulation may contribute to neuronal decline observed in conditions like Alzheimer's disease.
     - **Cardiovascular diseases:** Alterations in lysophospholipid metabolism can influence inflammatory pathways, which are critical in age-related cardiovascular conditions.

3. **Drug Interactions:**
   - Specific drug or drug class interactions with LYPLA2 are not extensively documented. However, enzymes with similar functions may be targeted by:
     - **Anti-inflammatory drugs:** Compounds that modulate lysophospholipid pathways may indirectly influence LYPLA2 activity.
     - **Cannabinoids:** Since LYPLA2 is known to hydrolyze 1-arachidonoylglycerol, its modulation may be relevant to cannabis-derived compounds affecting endocannabinoid signaling.

4. **Pathways and Biological Processes:**
   - **Lipid metabolism:** LYPLA2 plays a critical role in the metabolism of lysophospholipids, potentially influencing membrane dynamics and cellular signaling.
   - **Signal transduction:** Through its interaction with various proteins, LYPLA2 contributes to signaling pathways involved in growth and differentiation, particularly in neuronal contexts.
   - **Inflammatory response:** Its action on prostaglandin glycerol esters suggests a role in modulating inflammation and related responses.
   - **Neurobiology:** Interaction with GAP43 and potentially other neuronal proteins situates LYPLA2 within pathways related to neural development, repair, and plasticity.

These details illustrate the multifaceted role of LYPLA2 in biological processes and its potential implications in health and disease, especially concerning lipid signaling and neuronal function. Further research may illuminate its precise functions and associations in various biological contexts.