### GPRC5C Gene Overview

**Gene Symbol**: GPRC5C  
**Location**: Human chromosome 12q13.3  
**Protein Information**: The GPRC5C gene encodes a member of the type 3 G protein-coupled receptor (GPCR) family, characterized by a distinct seven-transmembrane domain motif. It is classified as a retinoic acid-inducible G-protein coupled receptor, indicating a potential role in mediating the cellular effects of retinoic acid in G protein signal transduction. There are two known transcript variants that encode different isoforms of the protein.

### 1. Associated Genes

While GPRC5C has not been extensively characterized in literature regarding specific gene associations, it is relevant to note that GPCRs typically interact with several genes involved in signaling pathways. Some associated genes in terms of GPCR signaling that might also relate to GPRC5C include:

- **RHOA**, involving Rho GTPase signaling
- **GNAQ** and **GNA11**, which are related to signaling pathways downstream of GPCRs
- Other retinoic acid responsive genes like **RARB** (retinoic acid receptor beta) and **RARA** (retinoic acid receptor alpha)

### 2. Aging and Age-Related Diseases

The precise role of GPRC5C in aging and age-related diseases is still under investigation. Some general details include:

- **Retinoic Acid Signaling**: Retinoic acid signaling has been implicated in various aspects of cellular differentiation and proliferation, which may influence aging processes and adaptions.
- **Possible Links to Cancer**: Given its role in GPCR signaling, alterations in GPRC5C may theoretically influence pathways related to cancer development, which is a significant age-related disease.
- **Neurodegenerative Conditions**: Some studies have suggested that retinoic acid signaling impacts neurogenesis and could potentially play a role in neurodegenerative diseases, though specific links to GPRC5C have not yet been robustly established.

### 3. Drug Interactions

As of the last knowledge update in October 2023, there are no specific drugs or drug classes directly known to interact with the GPRC5C gene listed in the literature. However, given its potential involvement in retinoic acid signaling, it might theoretically interact with:

- **Retinoids**: These compounds are known to modulate retinoic acid signaling.
- **Antagonists or Agonists of GPCRs**: Due to its classification as a GPCR, varying GPCR-targeting drugs may indirectly affect GPRC5C signaling.

### 4. Pathways and Biological Processes

GPRC5C is involved in several key biological pathways and processes, including:

- **Retinoic Acid Receptor Signaling Pathway**: GPRC5C may participate in the signaling cascade stimulated by retinoic acid.
- **G Protein-Coupled Receptor Signaling Pathway**: This encompasses a vast range of cell signaling mechanisms through the activation of G proteins.
- **Cellular Response to Retinoic Acid**: Involved in regulating gene expression in response to retinoids, which can impact development and cellular differentiation.
- **Regulation of Cell Proliferation and Differentiation**: Implicated in modulating pathways that control these essential cellular functions.

### Conclusion

While GPRC5C is an intriguing gene with a potentially significant role in retinoic acid signaling and GPCR pathways, its full functional implications, particularly in aging and drug interaction contexts, require further research to elucidate potential therapeutic or pathological connections.