### SULT1C3 Gene Overview

The **SULT1C3** gene is part of the sulfotransferase family and encodes an enzyme that catalyzes the transfer of sulfate groups to various substrates, utilizing 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as the sulfonate donor. The protein product of SULT1C3 is particularly involved in the sulfation of several endogenous compounds, including bile acids and thyroid hormones, as well as the metabolism of various xenobiotic compounds.

#### 1. Associated Genes
While specific genes consistently associated with **SULT1C3** are not always directly identified in databases, sulfotransferase genes within the SULT family often exhibit functional interrelationships. Related genes in the SULT family include:
- **SULT1A1**
- **SULT1A2**
- **SULT2A1**
- **SULT2B1**
- **SULT1C2** (closely related and may have overlapping functions)

#### 2. Aging and Age-Related Diseases
While direct associations of **SULT1C3** with aging and age-related diseases have not been extensively characterized, sulfotransferases, including SULT1C3, can play a role in hormonal regulation and detoxification processes that are crucial as organisms age. Alterations in sulfation pathways can affect the metabolism of hormones and drugs, which may influence senescence, age-related metabolic disorders, and susceptibility to certain age-related conditions, although specific studies linking SULT1C3 to these processes are limited.

#### 3. Drug Interactions
**SULT1C3** is known to interact with various drugs and compounds, particularly those that it sulfates during metabolism. Drugs and drug classes that may involve SULT1C3 include:
- **Non-steroidal anti-inflammatory drugs (NSAIDs)** (specific interactions need to be further studied)
- **Hormonal therapies** (potential interactions with thyroid hormones)
- **Certain chemotherapeutics** (e.g., some agents may be metabolized by sulfation)

Specific drug interactions remain to be characterized in clinical studies, but drugs that contain phenol or similar functional groups may undergo sulfation through the action of SULT1C3.

#### 4. Pathways and Biological Processes
**SULT1C3** is involved in multiple metabolic processes, including:
- **Cholesterol metabolism**: influences the sulfation of bile acids which are derived from cholesterol.
- **Xenobiotic metabolism**: contributes to the detoxification of environmental and dietary chemicals.
- **Endocrine regulation**: participating in the metabolism of thyroid hormones.

The gene is predicted to be active in the **cytoplasm**, aligning with its function in metabolic reactions. Key pathways associated with SULT1C3 include:
- **Bile Acid Metabolism**: responsible for modifying and detoxifying bile acids.
- **Drug Metabolism**: involved in phase II metabolism wherein drugs are conjugated to facilitate excretion.
- **Steroid Hormone Metabolism**: participating in the sulfation of steroid hormones, impacting their activity and clearance.

### Summary
In summary, **SULT1C3** is a key enzyme in the sulfation pathway with diverse roles in metabolism, particularly concerning bile acids and xenobiotics. While its direct associations with aging and specific age-related diseases require further elucidation, it remains a significant player in the metabolic landscape with potential implications in pharmacology and toxicology.