### SNORD116-25 Gene Overview

**Gene Symbol:** SNORD116-25  
**Type:** Small nucleolar RNA (snoRNA) gene  
**Location:** This gene is part of the SNORD116 gene cluster, located on chromosome 15 in humans. 

**Function:** SNORD116-25 is involved in the modification of ribosomal RNA (rRNA), which is a critical component of the ribosome, the cellular machinery responsible for protein synthesis. SnoRNAs like SNORD116-25 guide the methylation and pseudouridylation of rRNA.

### 1. Associated Genes
While the summaries provided by NCBI and UniProt may not detail specific associations, research has indicated that SNORD116-25 is part of a larger snoRNA cluster that is often studied in the context of related snoRNAs, including:

- **SNORD116-1**
- **SNORD116-2**
- **SNORD116-3**
- **SNORD116-7**
- **SNORD116-8**

These snoRNAs may have overlapping functions or regulatory importance, particularly in the context of cellular processes like RNA modification and processing.

### 2. Aging and Age-Related Diseases
SNORD116-25 belongs to a region of the genome that has been implicated in Prader-Willi Syndrome (PWS), a genetic disorder that can lead to obesity, intellectual disability, and developmental delays. Individuals with PWS often experience complications associated with aging, such as obesity-related metabolic disorders. 

Research into the broader implications of the SNORD116 gene cluster suggests potential roles in neurodevelopment and metabolism, which are critical aspects of both aging and age-related diseases. For instance, alterations in snoRNA function can contribute to dysregulation of gene expression patterns that might exacerbate age-related decline or vulnerability to certain diseases.

### 3. Drug Interactions
As of my latest knowledge, there are no specific drugs or drug classes explicitly documented to interact with SNORD116-25. However, given its role in fundamental cellular processes, there may be indirect implications through therapies targeting pathways involved with nucleolar functions, RNA processing, or disorders like Prader-Willi Syndrome. 

More research into the effects of specific compounds on snoRNA function and associated pathways is warranted, especially in related disease contexts.

### 4. Pathways and Biological Processes
SNORD116-25 is primarily involved in the following biological processes:

- **Ribosome Biogenesis:** It plays an important role in the processing and modification of rRNA, crucial for the formation of ribosomes.
- **RNA Modification:** The gene is involved in guiding methylation and other modifications of rRNA, impacting ribosomal function and protein synthesis.
- **Regulation of Gene Expression:** SnoRNAs are known to have roles in modulating gene expression, possibly influencing various cellular processes and development.

In terms of signaling pathways, while direct interactions with canonical pathways are less defined, discrepancies in snoRNA function can lead to alterations in cellular stress responses, developmental cues, and metabolic pathways.

### Summary
The SNORD116-25 gene is a small nucleolar RNA that plays a critical role in rRNA modification and ribosome formation. It is associated with neurodevelopmental disorders, particularly those impacting metabolism, like Prader-Willi Syndrome. There is an ongoing interest in its implications for aging and potential interactions with therapeutic regimens, although no direct drug interactions have been clearly established. Further studies continue to elucidate its intricate roles in cellular function and disease.