### CD247 Gene Overview

**Gene Symbol:** CD247  
**Location:** Chromosome 1 (1q23.3)  
**Entrez Gene ID:** 916  
**Function:** The CD247 gene encodes the T-cell receptor zeta (ζ) subunit, which is essential for T-cell receptor (TCR) signaling and the immune response. It forms part of the TCR-CD3 complex alongside other glycoproteins CD3E, CD3G, and CD3D.

### 1. Associated Genes
The CD247 gene is associated with several other genes in the immune signaling pathway, including, but not limited to:
- **CD3G** (CD3 gamma)
- **CD3E** (CD3 epsilon)
- **CD3D** (CD3 delta)
- **ZAP70** (Zeta-chain-associated protein kinase 70)
- **LCK** (Lymphocyte-specific protein tyrosine kinase)
- **FYN** (FYN proto-oncogene, Src family tyrosine kinase)

### 2. Aging and Age-related Diseases
Research has suggested that alterations in T-cell receptor signaling may impact aging and age-related diseases, including:
- **Immunosenescence:** Reduced expression and function of CD247 and related components leads to a decline in T-cell function, contributing to the diminished immune response observed in older adults.
- **Autoimmune Disorders:** Dysregulation of CD247 signaling can contribute to the pathogenesis of age-related autoimmune diseases, such as rheumatoid arthritis or systemic lupus erythematosus.
- **Cancer:** CD247 has been implicated in the immune evasion mechanisms of tumors, where age-related changes in T-cell functionality may impair anti-cancer immune responses.

### 3. Drug Interactions
While specific drugs targeting CD247 directly might not be well-characterized, several drug classes modulate T-cell responses through pathways involving CD247:
- **Monoclonal antibodies:** Therapies such as anti-PD-1/PD-L1 and anti-CTLA-4 agents (e.g., Pembrolizumab, Nivolumab) can have effects downstream of TCR-CD3 complex signaling, indirectly influencing CD247 activity.
- **Immunosuppressants:** Drugs like ciclosporin A and tacrolimus may affect T-cell activation, indirectly impacting the signaling pathway CD247 is involved in.

### 4. Pathways and Biological Processes
The CD247 gene is involved in several critical biological pathways and processes, including but not limited to:
- **T-cell Signaling Pathway:** Works with upstream molecules in TCR-mediated signal transduction.
- **Immune System Development:** Crucial for the proper differentiation and maturation of T-cells in the thymus.
- **Activation of T-lymphocytes:** Plays a vital role in transducing signals initiated by TCR engagement with antigens presented by MHC molecules.
- **Cytokine Production:** Indirectly influences the production of various cytokines following T-cell activation.

### Conclusion
The CD247 gene plays a fundamental role in adaptive immunity through its function in T-cell receptor signaling. Its associated genes and involvement in various pathways highlight its importance in immune response, while age-related effects and potential therapeutic targets illustrate the clinical significance of this gene in health and disease. Further research into CD247 may provide insights into immune dysfunction associated with aging and inform therapeutic strategies in age-related diseases.