### CEP83-DT Gene Overview

**Gene Symbol:** CEP83-DT

The CEP83-DT gene is a long non-coding RNA (lncRNA) that is expressed in various tissues. It is associated with the regulation of cilia formation and function, which plays a critical role in cellular signaling pathways.

### 1. Associated Genes

While specific gene interactions can be context-dependent, CEP83 and its associated non-coding RNA (CEP83-DT) are often linked with several other genes primarily involved in cilia formation and function. Some of these include:

- **CEP83**: This gene plays a central role in cilia biogenesis, and its product is essential for the organization of the microtubule structure in cilia.
- **TUBA1A**: This gene encodes a tubulin protein that is an important component of microtubules and is involved in cilia structure.
- **IFT genes (e.g., IFT88, IFT20)**: These are integral components of the intraflagellar transport machinery critical for cilia assembly.

### 2. Aging and Age-Related Diseases

While direct associations between CEP83-DT and aging or age-related diseases are still being investigated, cilia dysfunction has been implicated in several age-related conditions, including:

- **Neurodegenerative Diseases**: Impairment of cilia function has been linked to various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Altered expression of genes involved in ciliary function may contribute to the neuropathological processes in these disorders.
- **Ciliopathies**: Many diseases characterized by syndromic manifestations, such as Bardet-Biedl syndrome, are associated with cilium dysfunction, which can affect aging and lead to multi-organ issues.

### 3. Drug Interactions

As of the latest data, there are no specific drugs or drug classes directly known to interact with CEP83-DT. However, since it is linked to cilia function, potential modulation could occur via treatments affecting ciliary function or pathways involving ciliary assembly or signaling. 

Research continues on developing drug therapies targeting cilia-related pathways, which may indirectly involve CEP83-DT due to its role in cilia biology.

### 4. Pathways and Biological Processes

CEP83-DT is primarily involved in:

- **Cilia Biogenesis**: Contributing to the formation and stability of primary cilia.
- **Cell Signaling**: Playing a role in signaling pathways that are essential for several cellular processes, including development and homeostasis.
- **Cell Cycle Regulation**: Potential contribution to the regulation of processes that involve the cell cycle, reflecting the importance of cilia in cellular growth and differentiation.

### Conclusion

The CEP83-DT gene, as a long non-coding RNA, is implicated significantly in the formation and maintenance of cilia, which is critical for various signaling processes and cellular functions. While more specific details regarding its role in aging and clinical implications are still emerging, its involvement in cilia-associated pathways indicates potential intersections with various age-related diseases and disorders. Further research is necessary to elucidate the precise functions and interactions associated with CEP83-DT.