The PELI2 gene (Pellino E3 Ubiquitin Protein Ligase 2) encodes a protein that functions primarily as an E3 ubiquitin ligase involved in key cellular signaling events. Here is a detailed overview based on your requests:

### 1. Genes Associated with PELI2:
PELI2 interacts and is associated with several other genes and proteins, particularly those involved in immune response and signaling pathways. Some notable genes include:
- **IRAK1**: Interleukin-1 receptor-associated kinase 1, a member of the IL-1 receptor signaling complex. PELI2 mediates the polyubiquitination of IRAK1.
- **TRAF6**: TNF receptor-associated factor 6, which is part of the signaling pathways downstream of IL-1 and TLRs (Toll-like receptors).
- **MAP3K7**: Also known as TAK1, which is key in mediating signals leading to NF-κB activation and the MAPK pathways.
- **IL1B**: Interleukin 1 beta, which is involved in inflammatory responses.
- **MAPKAPK2**: Mitogen-activated protein kinase-activated protein kinase 2, involved in the MAPK signaling pathway.

### 2. Aging and Age-Related Diseases:
While direct associations between the PELI2 gene and aging or specific age-related diseases may not be extensively characterized in the literature, its involvement in inflammatory pathways suggests potential relevance. Aberrant regulation of inflammatory responses has been linked to various age-related conditions, such as:
- **Autoimmune Diseases**: Given PELI2’s role in immune signaling, alterations in its activity could contribute to autoimmune diseases that are more prevalent in the elderly.
- **Chronic Inflammation**: Aging is often associated with chronic low-grade inflammation, sometimes referred to as "inflammaging," where PELI2 could play a role in modulating the inflammatory response.
- **Cancer**: Alterations in ubiquitination processes can influence tumorigenesis, and chronic inflammation is a known risk factor for cancer development in older adults.

### 3. Drug Interactions:
As of the latest information, specific drugs directly targeting PELI2 were not prominently highlighted, but given its role in the immune response, pathways associated with the interleukin and TNF superfamilies may be influenced by:
- **Monoclonal Antibodies**: Drugs targeting IL-1β (such as canakinumab) affect pathways involving PELI2.
- **NF-κB Inhibitors**: Drugs affecting NF-κB signaling, which is influenced by PELI2-mediated pathways, may indirectly interact with PELI2’s functions.

### 4. Pathways and Biological Processes:
PELI2 is significantly involved in several key biological processes and pathways, including:
- **TLR Signaling Pathway**: Essential for the innate immune response, where it plays a role in activating downstream signaling of toll-like receptors.
- **IL-1 Signaling Pathway**: Particularly through the engagement of IL-1 receptors and the associated signaling cassette including IRAK and TRAF6.
- **Regulation of Protein Phosphorylation**: It acts upstream in processes that lead to the phosphorylation of various proteins.
- **MAPK Cascade**: Activating the MAPK signaling pathways, which are vital for cellular responses to growth signals.
- **Ubiquitin-Protein Ligase Activity**: Catalyzing the attachment of ubiquitin moieties, which can alter protein stability and activity, influencing various cellular processes.

In summary, PELI2 participates in crucial signaling pathways that govern immune responses and inflammation, and while direct links to aging and specific drugs may require further research, its regulatory functions in cell signaling imply important roles in health and disease.