### MAGI2-AS3 Gene Overview

**Gene Symbol:** MAGI2-AS3  
**NCBI Gene ID:** 29167  
**UniProt ID:** A6NDF8  

**Description:**  
MAGI2-AS3 is an antisense RNA transcript associated with the MAGI2 gene, which encodes a member of the membrane-associated guanylate kinase (MAGUK) family. These proteins are involved in the assembly of multiprotein complexes at cell junctions, playing essential roles in cell signaling, adhesion, and polarization.

### 1. Associated Genes
MAGI2-AS3 is primarily related to the MAGI2 gene, but it may also be functionally associated with other genes involved in cellular signaling and structural organization, particularly those in the MAGUK family such as:

- **MAGI1** (Membrane Associated Guanylate Kinase Inverted 1)
- **MAGI3** (Membrane Associated Guanylate Kinase Inverted 3)
- **DLG1** (Discs Large Homolog 1)
- **DLGAP1** (Discs Large-Associated Protein 1)

### 2. Aging and Age-Related Diseases
Current research has not directly connected MAGI2-AS3 with specific aging mechanisms or diseases; however, it is noteworthy that MAGUK family proteins, including MAGI2, have been implicated in processes such as synaptic plasticity, cell signaling, and tumorigenesis. These processes can be altered during aging and are associated with age-related diseases, including neurodegenerative disorders and cancers. Further research may reveal more explicit links between MAGI2-AS3 and aging.

### 3. Drugs or Drug Classes Interacting with MAGI2-AS3
As of now, there are no specific drugs or drug classes directly associated with MAGI2-AS3. However, research has highlighted that dysregulation of MAGUKs can lead to conditions that might be influenced by various pharmaceuticals, including those targeting signaling pathways in cancer. Future pharmacogenomic studies may discover specific interactions.

### 4. Pathways and Biological Processes
MAGI2-AS3 is likely involved in several biological processes and signaling pathways, primarily due to its association with MAGI2 and related proteins:

- **Cell Adhesion:** MAGUKs play critical roles in cell-cell adhesion.
- **Signaling Pathways:** They are involved in the regulation of various signaling pathways including the PI3K/AKT pathway and Wnt signaling.
- **Neurotransmitter Receptor Clustering:** MAGUKs assist in the clustering of synaptic receptors, which is foundational for synaptic function and plasticity.
- **Development and Differentiation:** They may be implicated in various developmental processes due to their role in maintaining cell polarity and junction integrity.

### Summary
MAGI2-AS3 is an antisense transcript closely related to the MAGI2 gene, which plays significant roles in cellular structure and signaling. While explicit associations of MAGI2-AS3 with aging, drugs, and other genes need more research, its connection to vital biological processes related to signaling and adhesion sets the stage for understanding its broader implications.