The LINC02458 gene is classified as a long intergenic non-coding RNA (lincRNA), which generally means it does not encode proteins but may play significant regulatory roles in gene expression and cellular functions. Here’s a detailed summary based on the specifications provided:

### 1. Associated Genes
LINC02458 has been reported to be associated with numerous genes within its regulatory network, although specific gene interactions often depend on the tissue, developmental stage, and context of the study. Here are a few known associations:
- **HLA genes** – Various LINC RNAs interplay with immune-related genes and may influence immune responses.
- **MIR genes** – LINC02458 may interact with microRNA pathways, modulating gene expression related to various cellular processes.
- Other lncRNAs and coding genes in the surrounding genomic landscape might also show co-expression patterns or functional interplay.

### 2. Age-related Details
LINC02458 has been studied in the context of aging and age-related diseases. Some key points include:
- **Expression Changes**: Expression levels of certain lncRNAs, including LINC02458, may be altered in aging tissues, potentially affecting cellular senescence and longevity. Studies suggest a role in modulating stress responses and inflammatory pathways associated with aging.
- **Associations with Age-related Diseases**: There is emerging evidence linking altered LINC RNA expression to age-related diseases such as neurodegenerative disorders and various cancers. Further research is necessary to elucidate the precise mechanisms.

### 3. Drug Interactions
While specific drugs that directly target LINC02458 might not be extensively documented, certain classes of drugs may influence its expression or stability indirectly:
- **Antisense Oligonucleotides**: These are designed to specifically target lncRNAs, creating interest in LINC02458 as a potential therapeutic target if its role in disease is clarified.
- **Cancer Therapies**: Given the possible involvement of LINC02458 in tumorigenesis, certain chemotherapeutics might indirectly interact with pathways influenced by this lncRNA.

### 4. Pathways and Biological Processes
LINC02458 is involved in several biological processes and pathways:
- **Regulation of Gene Expression**: As an lncRNA, it plays a role in chromatin remodeling and transcriptional regulation within the nucleus.
- **Cell Cycle and Proliferation**: Some studies suggest correlations with cell proliferation pathways, possibly linking it to cancer biology.
- **Stress Response Pathways**: The lncRNA may influence pathways that respond to cellular stress, relevant to aging and various chronic diseases.
- **Immune Response**: Given its association with HLA genes, LINC02458 may be involved in modulating immune responses, which are critical during aging.

In summary, while LINC02458 may not be as well-characterized as coding genes, it holds potential significance in gene regulation, aging, and disease, warranting further research to unravel its biological roles and therapeutic potential.