### Overview of CCDC140 Gene

**Gene Symbol:** CCDC140

**Function:** The CCDC140 gene encodes a protein that appears to be restricted to select higher primate species. Its protein product features a C-terminal coiled-coil domain, which is known for facilitating protein-protein interactions, contributing to various cellular functions including structural integrity and organization within the cell. Coiled-coil motifs are typically involved in the assembly of multi-protein complexes and may play roles in cellular signaling pathways.

### 1. Associated Genes

While specific gene associations are not detailed in the summaries you've provided, genes of interest that may correlate with CCDC140 include those involved in similar cellular processes or pathways. Genes related to the structural framework of cells, coiled-coil proteins, or those involved in higher primate evolution may be relevant for further exploration. Potential associated genes may include:

- **CCDC family members** (e.g., CCDC12, CCDC122) as they share similar structural features.
- **Genes involved in primate evolution** such as genes associated with spectrin or other cytoskeletal proteins.

Genetics research databases may also show co-expression patterns with other genes in relevant tissues and conditions.

### 2. Aging or Age-Related Disease Associations

As of the data available until October 2023, there is limited direct information linking CCDC140 to aging or age-related diseases. However, proteins with structural and signaling roles are generally considered vital in cellular processes that may be affected by aging. Dysregulation of coiled-coil proteins has implications in cellular aging, potentially influencing cell stability and organization over time.

Further studies may be needed to investigate whether mutations or expression changes in CCDC140 contribute to age-related diseases, particularly in the context of higher primates.

### 3. Drug Interactions

Currently, there are no specific drugs or drug classes explicitly documented to interact with the CCDC140 gene product in the available literature. Nonetheless, drugs targeting pathways involving coiled-coil proteins, signaling pathways, or related cellular mechanisms could have indirect effects. More comprehensive pharmacogenomic databases and ongoing research could provide additional insights.

### 4. Pathways and Biological Processes

The CCDC140 gene may participate in several biological processes, though specific pathways may not be well delineated in the current literature. Given its structural role and occurrence in higher primates, notable areas may include:

- **Cytoskeleton organization:** The coiled-coil domain suggests involvement in forming or maintaining cellular structures and scaffolding.
- **Protein-protein interactions:** Implicated in facilitating communication and complex formation among proteins.
- **Cellular signaling pathways:** May participate in various signaling cascades due to its structural capabilities.

### Conclusion

CCDC140 is a gene encoding a coiled-coil protein relevant to structural and possibly signaling functions in higher primates. While associations with specific genes, age-related effects, drug interactions, and pathways require further study, the emphasis on its structural features suggests substantial biological significance. Ongoing research is critical to illuminate further its functional roles and implications in health and disease.