### Gene Overview: SNORD105B

**Gene Symbol**: SNORD105B

- **Type**: Small nucleolar RNA (snoRNA).
- **Function**: SNORD105B is involved in the modification of rRNA, specifically in the 2'-O-methylation of ribosomal RNA. It is classified as a C/D box snoRNA, which plays a crucial role in the biogenesis and maturation of ribosomes.

### Associated Genes

As a snoRNA, SNORD105B may interact with certain ribosomal protein genes and other RNA processing genes. However, specific direct associations have not been extensively documented in the literature compared to other more studied snoRNAs. Generally, snoRNAs can be associated with the following types of genes:
  
- **Ribosomal protein genes** such as RPL (ribosomal protein L) genes.
- **RNA-binding proteins** involved in the processing and modification of RNA, including those in the nucleolus.

### Aging and Age-Related Diseases

While specific studies directly linking SNORD105B to aging or particular age-related diseases may be sparse, small nucleolar RNAs, in general, have been implicated in processes that could affect aging, such as:

- **Ribosome biogenesis**: Proper ribosome function is crucial for cellular aging, and modifications facilitated by snoRNAs are essential for maintaining cellular function.
- **Cellular stress responses**: Changes in the expression and functionality of snoRNAs have been associated with various forms of cellular stress, which could have implications for age-related decline.

**Known Associations**: There may not yet be a comprehensive dataset specifically tying SNORD105B to certain pathways in aging or specific age-related diseases, but research into the general role of snoRNAs in cellular aging is ongoing.

### Drug Interactions

Currently, there are no specific drugs or drug classes known to interact directly with SNORD105B. However, it's essential to note that the modulation of snoRNA expression can influence broader cellular processes, which may be targeted by drugs indirectly. This can include drugs that impact ribosome biogenesis or general RNA processing pathways. Research into the pharmacological modulation of snoRNAs is limited, and more specific interactions may warrant future investigation.

### Pathways and Biological Processes

SNORD105B is involved in several biological processes including:

1. **Ribosome Biogenesis**: As a snoRNA, SNORD105B contributes to ribosomal RNA modification, which is critical for the assembly and function of ribosomes.
   
2. **RNA Methylation**: A key role of SNORD105B includes the 2'-O-methylation of target RNAs, impacting various cellular RNA species beyond just rRNA.

3. **Regulation of Gene Expression**: By influencing the processing and stability of rRNA, SNORD105B indirectly affects the overall protein synthesis, contributing to gene expression regulation.

4. **Nucleolar Function**: It contributes to the essential structural and functional roles of the nucleolus in the cell.

In summary, SNORD105B is a small nucleolar RNA involved primarily in the modification of ribosomal RNA. While there are limited direct studies linking it to specific diseases or drugs, its role in ribosome biogenesis and cellular processes may have broader implications in aging and the functioning of cellular mechanisms. Further research is needed to elaborate on its specific interactions and biological significance.