### DIAPH1-AS1 Gene Summary

**Gene Symbol:** DIAPH1-AS1  
**Type:** Long non-coding RNA (lncRNA)  
**Location:** Chromosome 5

#### 1. Associated Genes
DIAPH1-AS1 is an antisense transcript of the DIAPH1 gene, which encodes a formin involved in actin nucleation and polymerization. While comprehensive associations may vary, genes and pathways linked to DIAPH1-AS1 and DIAPH1 include:

- **DIAPH1:** The primary gene it is associated with, involved in cytoskeletal dynamics.
- **RhoA/RhoGTPases:** Related signaling pathways that may interact with DIAPH1 function.
- Other genes involved in actin dynamics or regulatory networks could also be considered indirectly associated.

#### 2. Aging and Age-related Diseases
Research has suggested roles for DIAPH1 and its associated lncRNA in cellular processes relevant to aging and age-related conditions such as:

- **Cell Migration and Adhesion:** Alterations in DIAPH1 may impact cellular movement, which can influence tissue repair, regeneration, and, consequently, aging.
- **Neurodegenerative Diseases:** Variants in DIAPH1 have been investigated concerning diseases like Amyotrophic Lateral Sclerosis (ALS), suggesting potential links between this gene and mechanisms of neurodegeneration with age.
  
These connections are an area of active investigation, often reflecting the complex interplay between cytoskeletal dynamics, cellular aging, and disease.

#### 3. Drug Interactions
As of the latest data (up to October 2023), specific drug interactions directly targeting DIAPH1-AS1 are not well characterized. However, in the context of the DIAPH1 protein, drugs that target cytoskeletal dynamics (e.g., cytochalasins) might indirectly influence the expression or function of the lncRNA through modulation of related pathways.

Additionally, ongoing research into targeted cancer therapies may indirectly relate to the expression of lncRNAs, including those that influence DIAPH1, although direct FDA-approved drugs interacting with DIAPH1-AS1 have not been specified.

#### 4. Pathways and Biological Processes
DIAPH1-AS1 participates in several biological processes and pathways, primarily through its association with DIAPH1 and related mechanisms:

- **Actin Cytoskeleton Organization:** As an antisense RNA of DIAPH1, it likely contributes to the regulation of cytoskeletal dynamics crucial for cell motility, division, and signal transduction.
- **Cell Cycle Regulation:** The regulatory network involving DIAPH1 may be associated with cell proliferation and growth control mechanisms.
- **Signal Transduction:** Given its involvement in cytoskeletal integrity, DIAPH1-AS1 potentially interacts with signaling pathways like the Rho signaling pathway, which regulates various cellular processes including stress response and migration.

In summary, DIAPH1-AS1 is a long non-coding RNA associated with the DIAPH1 gene and implicated in cytoskeleton organization, potential neurodegenerative mechanisms, and various cellular processes influencing aging and disease. Further research is necessary to fully elucidate its roles and interactions, particularly in pharmacology and aging-related pathways.