### RABL3 Gene Overview

**Gene Symbol:** RABL3

**Function and Characteristics:**  
RABL3 is predicted to enable GTP binding, GTPase activity, and protein homodimerization. It plays a crucial role in the regulation of Ras protein signal transduction and influences the lipidation of proteins. RABL3 is functionally active within the endomembrane system and has been implicated in pancreatic cancer. Its primary roles include regulation of KRAS signaling, modulation of cell proliferation, and influencing the prenylation of KRAS, as well as potentially other small GTPases. Furthermore, it is required for lymphocyte development and function, but not for myeloid cell development.

### 1. Associated Genes
While specific additional genes directly associated with RABL3 may not be explicitly mentioned in the summaries, it is commonly linked to the following genes due to its role in the KRAS signaling pathway:

- **KRAS**: Key player in many signaling pathways related to cell growth and proliferation.
- **NRAS** and **HRAS**: Other members of the RAS family that may interact or be regulated in conjunction with RABL3.
- **BRAF**: Often involved in pathways that intersect with RAS signaling.

### 2. Aging and Age-Related Diseases
While there is no direct mention in the summaries provided, the involvement of RABL3 in KRAS signaling can impact cellular processes related to aging. Dysregulation of Ras signaling is known to contribute to age-related diseases, including cancer, particularly because aberrant signaling can lead to uncontrolled cell growth and proliferation. Impairment in lymphocyte function due to age could also be influenced by changes in RABL3 activity, possibly impacting immune responses in aging.

### 3. Known Drug Interactions
RABL3 itself does not have direct drug interactions documented in major pharmacological databases; however, considering its role in KRAS signaling, it may indirectly affect responses to treatments involving:

- **Small-molecule inhibitors targeting the KRAS pathway**: These can include drugs that specifically target KRAS or downstream effectors like MEK inhibitors (e.g., Trametinib) or RAF inhibitors (e.g., Vemurafenib).
- **Immunotherapy approaches**: As it plays a role in lymphocyte function, modulation of its activity could impact the effectiveness of certain immunotherapies.

### 4. Pathways and Biological Processes
RABL3 is involved in several key biological processes and signaling pathways:

- **Ras Protein Signal Transduction**: Central to many growth and differentiation pathways in cells.
- **Regulation of Protein Prenylation**: Important for membrane localization and function of various proteins, particularly small GTPases.
- **Cell Proliferation**: Modulates processes essential for cellular growth and division.
- **Lymphocyte Development and Function**: Plays a role in the immune response, promoting lymphocyte maturation.

### Summary
Overall, RABL3 is a multifunctional gene primarily involved in the regulation of RAS signaling, with implications in cancer biology and immune function. Its interactions and roles in age-related processes further emphasize the importance of studying this gene in both cancer and immune aging contexts.