 249
rs193236081
rs4938021
rs139237746
rs12903563
rs12938775
rs1557341
rs1296196917q21.31
11q23.2
11p15.4
15q24.3
17p13.3
18q12.2
18q12.2>10 genesav
DRD2
ADM, AMPD3
LINGO1
PAFAH1B1
CELF4
CELF4
Lo et al. 
(2017)Big Five Neuroticism
Extraversion
Openness to experience
Agreeableness
Conscientiousness122,886b
122,886
 76,600c
 76,600
 76,600rs6981523
rs9611519
rs57590327
rs2164273
rs6481128
rs1426371
rs7498702
—
rs38144248p23.1
22q
3p
8p
10q
12q
16p
—
5qXKR6
L3MBTL2, CHADL
GBE1
MTMR9
PCDH15
WSCD2
RBFOX1
—
—
LINC00461
Nagel et al. 
(2018)(Latent scores based on) 
NEO-PI-R/FFI, TCI and 
EPQ, and EPQ(Harmonized) 
neuroticism449,484d136 loci (of 
which 122 
were new 
at time of 
analysis)Several 
chromosomes; 
see article 
for more 
information.599 genes; see article for more 
information.
Note.  EPQ, Eysenck Personality Questionnaire; FFI, Five-Factor Inventory; SNP, single-nucleotide polymorphism; TCI, Temperament and Character Inventory.
aThis sample is a combination of the GPC samples (de Moore et al., 2015) and the U.K. Biobank sample (Smith et al., 2016).
bThis sample is a combination of the GPC-2 (de Moor et al., 2015) and the 23andMe sample.
cThis sample is a combination of the GPC-1 (de Moor et al., 2012) and the 23andMe sample.
dThis sample is a combination of the GPC-2 (de Moor et al., 2015), the 23andMe sample and the U.K. Biobank sample.