248 
TABLE 10.1.  Overview of Meta-Analyses of Genomewide Association Studies for Personality
Study Personality test Personality traitsSample size 
discovery 
setSample size 
replication 
setGenomewide significant hits
Index SNP Location Associated gene
de Moor et 
al. (2012)NEO-FFI Neuroticism
Extraversion
Openness to experience
Agreeableness
Conscientiousness 17,375 3,294 —
rs1477268/
rs2032794
—
rs2576037—
5q14.3
—
18q21.1—
RASA1
—
KATNAL2
de Moor et 
al. (2015)Latent scores based on 
NEO-PI-R/FFI, TCI and 
EPQHarmonized 
neuroticism 63,661 9,786 rs35855737 3p14 MAGI1
van den Berg 
et al. (2016)Latent scores based on 
NEO-PI-R/FFI, TCI and 
EPQHarmonized 
extraversion 63,030 9,783 -
Smith et al. 
(2016)EPQ Neuroticism 106,716 — rs490647
rs4653663
rs12637928
rs62353264
rs12682352
rs12378446
rs4977844
rs111433752
rs11872641p34.3
1q42.12
3q13.13
4q32.3
8p23.1
9p23
9p21.3
17q21.31
18q12.2GRIK3
ENAH, SRP9
PVRL3
TMEM192, KLHL2, MSMO2
>10 genes
PTPRD
ELAVL2
>10 genes
CELF4
Okbay et al. 
(2016)(Latent scores based on) 
NEO-PI-R/FFI, TCI and 
EPQ(Harmonized) 
neuroticism170,911a— rs35688236
rs2572431
rs10960103
rs21504623p22.3
8p23.1
9p23
9p21.3>10 genes
PTPRD
ELAVL2