Afatinib과 dacomitinib은 ATP 결합 부위에 비가역적으로 결합하여 작용하고, erbB family에 포함된 다른 eGFR에도 작용한다는 차이점이 있다.
Afatinib and dacomitinib act by irreversibly binding to the ATP binding site, and the difference is that they also act on other eGFRs included in the erbB family.