2004년에 EGFR-TKD에 돌연변이가 확인되었고 일부 EGFR-TKD에 돌연변이가 있는 환자에서 EGFR-TKI8, 17에 우수한 반응을 보였다.
However, in 2004, mutations in the EGFR-TKD were identified and some of the patients who had mutations in EGFR-TKD showed an excellent response to the EGFR-TKI8, 17.