8-oh-dpat 8-oh-dpat 8-oh-dpat is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-ht1a receptor. it was one of the first major 5-ht1a receptor full agonists to be discovered. 8-oh-dpat names systematic iupac name 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol identifiers cas number 78950-78-4 y 3d model (jsmol) interactive imageinteractive image abbreviations 8-oh-dpat chebi chebi:73364 n chembl chembl56 y chemspider 1183 y5036174 (r) y8301316 (s) y iuphar/bps 7 mesh 8-hydroxy-2-(di-n-propylamino)tetralin pubchem cid 12206603866 (r)10125797 (s) unii iws1724px6 y comptox dashboard (epa) dtxsid30897384 inchi inchi=1s/c16h25no/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18h,3-4,8-12h2,1-2h3 ykey: asxgjmskwnbenu-uhfffaoysa-n yinchi=1/c16h25no/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18h,3-4,8-12h2,1-2h3key: asxgjmskwnbenu-uhfffaoyay smiles cccn(ccc)c1ccc2cccc(o)c2c1cccn(ccc)c1ccc2=c(c1)c(o)=cc=c2 properties chemical formula c16h25no molar mass 247.382 g·mol−1 log p 3.711 acidity (pka) 10.539 basicity (pkb) 3.458 pharmacology pharmacokinetics: biological half-life 1.5 hours except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references originally believed to be selective for the 5-ht1a receptor, 8-oh-dpat was later found to act as a 5-ht7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well. in animal studies, 8-oh-dpat has been shown to possess antidepressant, anxiolytic, serenic, anorectic, antiemetic, hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.