tolimidone tolimidone tolimidone (cp-26154; mlr-1023) is a compound which was discovered by scientists at pfizer, was found to stimulate secretion of gastric mucosa, and was in development by pfizer as a drug candidate to treat gastric ulcers but was abandoned. after the patent on the compound expired, scientists at the company melior discovery identified it as a potential drug candidate for diabetes through a phenotypic screen. the company proceeded to show that mlr-1023 is an allosteric activator of lyn kinase with an ec50 of 63 nm. as of 2012 melior was repurposing it for diabetes. in june 2016, the company reported positive results from their phase 2a clinical study in diabetic subjects tolimidoneclinical dataother namescp-26154, mlr-1023identifiers iupac name 5-(3-methylphenoxy)pyrimidin-2(1h)-one cas number41964-07-2pubchem cid39065chemspider35751uniimu3jd8e9iskeggd06182chemblchembl8030comptox dashboard (epa)dtxsid50194786 echa infocard100.230.742 chemical and physical dataformulac11h10n2o2molar mass202.213 g·mol−13d model (jsmol)interactive image smiles o=c2/n=c\c(\oc1cc(ccc1)c)=c/n2