e-4031 e-4031 e-4031 is an experimental class iii antiarrhythmic drug that blocks potassium channels of the herg-type. e-4031clinical dataother names(1--4-(4-methylsulfonyl-aminobenzoyl)piperidine)identifiers iupac name n-piperidine-4-carbonyl]phenyl] cas number113558-89-7 113559-13-0 (dihydrochloride)pubchem cid3185iuphar/bps2605chemspider3073unii1l1k8x5df9chemblchembl327980comptox dashboard (epa)dtxsid00150458 chemical and physical dataformulac21h27n3o3smolar mass401.53 g·mol−13d model (jsmol)interactive image smiles cc1cccc(n1)ccn2ccc(cc2)c(=o)c3ccc(cc3)ns(=o)(=o)c inchi inchi=1s/c21h27n3o3s/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27/h3-9,18,23h,10-15h2,1-2h3key:sruisgshwfjion-uhfffaoysa-n (verify) chemistry e-4031 is a synthesized toxin that is a methanesulfonanilide class iii antiarrhythmic drug. target e-4031 acts on a specific class of voltage-gated potassium channels mainly found in the heart, the herg channels. herg channels (kv11.1) mediate the ikr current, which repolarizes the myocardial cells. the herg channel is encoded by ether-a-go-go related gene (herg). mode of action e-4031 blocks herg-type potassium channels by binding to the open channels. its structural target within the herg-channel is unclear, but some other methanesulfonanilide class iii antiarrhythmic drugs are known to bind to the s6 domain or c-terminal of the herg-channel. reducing ikr in myocardial cells prolongs the cardiac action potential and thus prolongs the qt-interval. in non-cardiac cells, blocking ikr has a different effect: it increases the frequency of action potentials. toxicity as e-4031 can prolong the qt-interval, it can cause lethal arrhythmias. therapeutic use e-4031 is solely used for research purposes. so far, one clinical trial has been conducted to test the effect of e-4031 on prolongation of the qt-interval.