clostridioides clostridioides clostridioides is a genus of gram-positive bacteria, which includes clostridioides difficile, a human pathogen causing an infectious diarrhea. clostridioides se micrograph of clostridium difficile colonies from a stool sample scientific classification domain: bacteria phylum: bacillota class: clostridia order: eubacteriales family: peptostreptococcaceae genus: clostridioideslawson and rainey (2016) selected species clostridioides difficile clostridioides mangenotii taxonomy the genus clostridioides was created to describe a few species formerly in the genus clostridium which have been shown to be their own genetically distinct genus using 16s rrna gene sequencing analysis. however, both names are still in use and valid under the international code of nomenclature of prokaryotes. description they are obligate anaerobes capable of producing endospores. the normal, reproducing cells of clostridioides, called the vegetative form, are rod-shaped, which gives them their name, from the greek κλωστήρ or spindle. clostridioides endospores, like clostridium endospores, have a distinct bowling pin or bottle shape, distinguishing them from other bacterial endospores, which are usually ovoid in shape.