reticular pigmented anomaly of the flexures reticular pigmented anomaly of the flexures reticular pigmented anomaly of the flexures (also known as dark dot disease and dowling–degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.: 856 it is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. this condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium. reticular pigmented anomaly of the flexuresother nameskitamura reticulate acropigmentationspecialtydermatology dark dot disease is associated with krt5.