padeliporfin padeliporfin padeliporfin, sold under the brand name tookad, is a medication used to treat men with prostate cancer. padeliporfinclinical datatrade namestookadother nameswst-09, wst-11license data eu ema: by inn atc codel01xd07 (who) legal statuslegal status uk: pom (prescription only) eu: rx-only in general: ℞ (prescription only) identifiers iupac name 3-propanoic acid;palladium(2+) cas number759457-82-4 ypubchem cid56841556drugbankdb15575uniieeo29fzt86keggd10973comptox dashboard (epa)dtxsid20997307 chemical and physical dataformulac37h43n5o9pdsmolar mass840.26 g·mol−13d model (jsmol)interactive image smiles cc1(c2=nc1=cc3=c(c(=c(3)c(=c4((c(=n4)c=c5c(=c(c(=c2)5)c(=o)c)c)c)ccc(=o)o)cc(=o)oc)c(=o)nccs(=o)(=o)o)c)c. inchi inchi=1s/c37h45n5o9s.pd/c1-8-22-17(2)25-16-30-33(21(6)43)19(4)27(40-30)14-26-18(3)23(9-10-31(44)45)35(41-26)24(13-32(46)51-7)36-34(37(47)38-11-12-52(48,49)50)20(5)28(42-36)15-29(22)39-25;/h14-18,22-23h,8-13h2,1-7h3,(h5,38,39,40,41,42,43,44,45,47,48,49,50);/q;+2/p-2/t17-,18+,22-,23+;/m1./s1key:mzrdsgwdvdesrc-vnwqtdigsa-l the most common side effects include problems with urinating (pain, inability to pass urine, strong urge to pass urine, frequent urination, and incontinence), sexual problems (erectile dysfunction and ejaculation failure), blood in urine, urinary tract infection, and pain and bleeding around the genital area. padeliporfin was approved for medical use in the european union in november 2017. the active ingredient in tookad is padeliporfin di-potassium. medical uses padeliporfin is indicated as monotherapy for adults with previously untreated, unilateral, low risk, adenocarcinoma of the prostate with a life expectancy of at least ten years and clinical stage t1c or t2a; gleason score ≤ 6, based on high-resolution biopsy strategies; prostate-specific antigen (psa) ≤ 10 ng/ml; three positive cancer cores with a maximum cancer core length of 5 mm in any one core or 1-2 positive cancer cores with ≥ 50% cancer involvement in any one core or a psa density ≥ 0.15 ng/ml/cm3. society and culture legal status padeliporfin was approved for use in the european union in november 2017. in february 2020, the oncologic drugs advisory committee of the us food and drug administration (fda) voted against approving padeliporfin di-potassium powder for solution for injection, submitted by steba biotech, s.a. the proposed indication (use) for the product is for the treatment of men with localized prostate cancer, meeting the following criteria: stage t1-t2a and prostate specific antigen less than or equal to 10 ng/ml and gleason grade group 1 based on transrectal ultrasound guided biopsy or unilateral gleason grade group 2 based on multiparametric magnetic resonance imaging-targeted biopsy with less than 50 percent of cores positive.