amg-3 amg-3 amg-3 (part of the am cannabinoid series) is an analgesic drug which is a cannabinoid agonist. it is a derivative of δ8thc substituted with a dithiolane group on the 3-position side chain. amg-3 is a potent agonist at both cb1 and cb2 receptors with a ki of 0.32nm at cb1 and 0.52nm at cb2, and its particularly high binding affinity has led to it being used as a template for further structural development of novel cannabinoid drugs. it has sedative and analgesic effects, with analgesia lasting for up to 36 hours after administration. amg-3identifiers iupac name (6ar,10ar)-3-(2-hexyl-1,3-dithiolan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzochromen-1-ol cas number179044-94-1 npubchem cid10002952chemspider8178532 nuniiu90k6d923kchemblchembl476325 nchemical and physical dataformulac25h36o2s2molar mass432.68 g·mol−13d model (jsmol)interactive image smiles ccccccc4(sccs4)c(cc1o)cc(oc(c)(c)c2cc=3)c1c2cc=3c inchi inchi=1s/c25h36o2s2/c1-5-6-7-8-11-25(28-12-13-29-25)18-15-21(26)23-19-14-17(2)9-10-20(19)24(3,4)27-22(23)16-18/h9,15-16,19-20,26h,5-8,10-14h2,1-4h3/t19-,20-/m1/s1 nkey:jecxxfxyjaqvah-wojbjxkfsa-n n ny (what is this?) (verify)