spinorphin spinorphin spinorphin is an endogenous, non-classical opioid peptide of the hemorphin family first isolated from the bovine spinal cord (hence the prefix spin-) and acts as a regulator of the enkephalinases, a class of enzymes that break down endogenous the enkephalin peptides. it does so by inhibiting the enzymes aminopeptidase n (apn), dipeptidyl peptidase iii (dpp3), angiotensin-converting enzyme (ace), and neutral endopeptidase (nep). spinorphin is a heptapeptide and has the amino acid sequence leu-val-val-tyr-pro-trp-thr (lvvypwt). it has been observed to possess antinociceptive, antiallodynic, and anti-inflammatory properties. the mechanism of action of spinorphin has not been fully elucidated (i.e., how it acts to inhibit the enkephalinases), but it has been found to act as an antagonist of the p2x3 receptor, and as a weak partial agonist/antagonist of the fp1 receptor. spinorphin names iupac name l-leucyl-l-valyl-l-valyl-l-tyrosyl-l-prolyl-l-tryptophyl-l-threonine other names lvvypwt; lvv-hemorphin-4 identifiers cas number 137201-62-8 3d model (jsmol) interactive image chemspider 2339355 iuphar/bps 1026 pubchem cid 3081832 comptox dashboard (epa) dtxsid70160105 inchi inchi=1s/c45h64n8o10/c1-23(2)19-31(46)39(56)50-37(25(5)6)43(60)51-36(24(3)4)42(59)49-34(20-27-14-16-29(55)17-15-27)44(61)53-18-10-13-35(53)41(58)48-33(40(57)52-38(26(7)54)45(62)63)21-28-22-47-32-12-9-8-11-30(28)32/h8-9,11-12,14-17,22-26,31,33-38,47,54-55h,10,13,18-21,46h2,1-7h3,(h,48,58)(h,49,59)(h,50,56)(h,51,60)(h,52,57)(h,62,63)/t26-,31+,33+,34+,35+,36+,37+,38+/m1/s1key: bxifnvgzimfbqb-dydshoknsa-ninchi=1/c45h64n8o10/c1-23(2)19-31(46)39(56)50-37(25(5)6)43(60)51-36(24(3)4)42(59)49-34(20-27-14-16-29(55)17-15-27)44(61)53-18-10-13-35(53)41(58)48-33(40(57)52-38(26(7)54)45(62)63)21-28-22-47-32-12-9-8-11-30(28)32/h8-9,11-12,14-17,22-26,31,33-38,47,54-55h,10,13,18-21,46h2,1-7h3,(h,48,58)(h,49,59)(h,50,56)(h,51,60)(h,52,57)(h,62,63)/t26-,31+,33+,34+,35+,36+,37+,38+/m1/s1key: bxifnvgzimfbqb-dydshoknbn smiles o=c(n(c(=o)n(c(=o)n(c(=o)n1ccc1c(=o)n(c(=o)n(c(=o)o)(o)c)cc3c2ccccc2c3)cc4ccc(o)cc4)c(c)c)c(c)c)(n)cc(c)c properties chemical formula c45h64n8o10 molar mass 877.037 g/mol except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references