broparestrol broparestrol broparestrol (inn) (brand names acnestrol, longestrol; former developmental code name ln-107), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (bdpe), is a synthetic, nonsteroidal selective estrogen receptor modulator (serm) of the triphenylethylene group that has been used in europe as a dermatological agent and for the treatment of breast cancer. the drug is described as slightly estrogenic and potently antiestrogenic, and inhibits mammary gland development and suppresses prolactin levels in animals. it is structurally related to clomifene and diethylstilbestrol. broparestrol is a mixture of e- and z- isomers (ln-1643 and ln-2299, respectively), both of which are active and are similarly antiestrogenic but, unlike broparestrol, were never marketed. broparestrolclinical datatrade namesacnestrol, longestrolother namesln-107; α-bromo-α,β-diphenyl-β-p-ethylphenylethylene; bdpepregnancycategory x (contraindicated) routes ofadministrationby mouthdrug classselective estrogen receptor modulatorlegal statuslegal status in general: ℞ (prescription only) identifiers iupac name 1-(2-bromo-1,2-diphenylethenyl)-4-ethylbenzene cas number479-68-5z-isomer: 22393-63-1pubchem cid3032769chemspider2297663unii4f4uxv47yiz-isomer: d6cyj2ni2lchemical and physical dataformulac22h19brmolar mass363.298 g·mol−13d model (jsmol)interactive image smiles ccc1ccc(cc1)/c(=c(\c2ccccc2)/br)/c3ccccc3 inchi inchi=1s/c22h19br/c1-2-17-13-15-19(16-14-17)21(18-9-5-3-6-10-18)22(23)20-11-7-4-8-12-20/h3-16h,2h2,1h3/b22-21+key:oqcytshiqnpjic-qurgraslsa-n