david syndrome david syndrome david syndrome, short for deficient anterior pituitary with variable immune deficiency syndrome, is a rare genetic disorder that is characterized by adrenocorticotropic hormone deficiency combined with common variable immunodeficiency and hypogammaglobulinemia, which is caused by a heterozygous mutation in the nfkb2 gene. it is also known to lead to symptomatic hypoglycemia. david syndromespecialtymedical genetics, immunology