pe. films can be manufactured via coextrusion or lamination. wvtr values of commercial cyclic olefin-based pharmaceutical blister films typically range from 0.20 to 0.35 g/m2/day at 38 °c/90% rh. unlike pvc and other common pharmaceutical barrier resins, cyclic olefin resins do not contain chlorine or other halogens in their molecular structure, being composed solely of carbon and hydrogen. cyclic olefin resins are available which comply with pharmaceutical packaging guidelines in the us, europe, and japan. cold form foil cold form foil film (or cold-formed foil) is made of a 3-layer laminate: pvc/aluminum/polyamide. the pvc side is on the inside in contact with the product. cold form foil blister pack lidding foils pharmaceutical blister packs are mostly closed by a push-through or peel-open lidding foil. the most common lidding foil with push-through features is 20µ hard tamper aluminum, which can be supplied pinhole-free from the producers. the lidding foil is coated with a heat-seal lacquer on the inside and a print primer on the outside. benefits cost savings blister packaging is a cost-effective way of showcasing a product. due to the nature of the material and design, it makes it more cost-effective than other types of packages that are on the market. there are several different types of blister packaging – face seal, trap, mock, slide and interactive. each one has its unique qualities and price points, from entry level to high end. advertising space there is a wide range of colors and finishes that blister packaging can be constructed to feature. manufacturers can use that to help make their products stand out on shelves. blister packaging allows either the manufacturer or retailer to include promotional materials or advertisements to help build a brand and increase customer loyalty. clear product display blister packaging helps shoppers see product, further aiding in their purchase decision. more than half of shoppers believe it is important to see a product through its packaging. theft deterrent packaging to prevent retail theft, packages are specifically designed so that the customer cannot "touch and feel" the product. clear, protective, and durable thermoformed plastic packaging enables the customer to fully view the product while maintaining the security of the product. blister packaging can easily be sealed using heat sealing machinery. tamper evident a tamper-evident package, according to the regulations of the food and drug administration (21 cfr § 211.132), "is one having one or more indicators or barriers to entry which, if breached or missing, can reasonably be expected to provide visible evidence to consumers that tampering has occurred". in addition, the indicator or barrier must be "distinctive by design", which means the tamper-evident feature is designed from material not readily available to the public. therefore, it cannot be easily duplicated. the labeling must also include a description of the safety feature. for blister packaging, each tablet or capsule is individually sealed, so any form of tampering is immediately visible. the product label needs to include a statement similar to the following: "do not use if blister is cut or broken". suicide prevention medication placed in blister packs has reduced intentional overdoses.