nisoldipine nisoldipine nisoldipine is a pharmaceutical drug used for the treatment of chronic angina pectoris and hypertension. it is a calcium channel blocker of the dihydropyridine class. it is sold in the united states under the proprietary name sular. nisoldipine has tropism for cardiac blood vessels. nisoldipineclinical datatrade namessular, baymycard, syscorahfs/drugs.commonographmedlineplusa696009routes ofadministrationoralatc codec08ca07 (who) legal statuslegal status us: ℞-only pharmacokinetic databioavailability4–8%protein binding>99%metabolismcyp3a4elimination half-life7–12 hoursexcretion70–80% via urineidentifiers iupac name (rs)-isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate cas number63675-72-9 ypubchem cid4499iuphar/bps2524drugbankdb00401 nchemspider4343 nunii4i8hab65szkeggd00618 ychebichebi:7577 nchemblchembl1726 ncomptox dashboard (epa)dtxsid0023371 echa infocard100.058.534 chemical and physical dataformulac20h24n2o6molar mass388.414 g·mol−13d model (jsmol)interactive image smiles cc1=c(c(c(=c(n1)c)c(=o)occ(c)c)c2ccccc2(=o))c(=o)oc inchi inchi=1s/c20h24n2o6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21h,10h2,1-5h3key:vkqfcgnpdricfg-uhfffaoysa-n ny (what is this?) (verify) it was patented in 1975 and approved for medical use in 1990. contraindications nisoldipine is contraindicated in people with cardiogenic shock, unstable angina, myocardial infarction, and during pregnancy and lactation. adverse effects common side effects are headache, confusion, fast heartbeat, and edema. hypersensitivity reactions are rare and include angioedema. interactions the substance is metabolized by the liver enzyme cyp3a4. consequently, cyp3a4 inducers such as rifampicin or carbamazepine could reduce the effectiveness of nisoldipine, while cyp3a4 inhibitors such as ketoconazole increase the amount of nisoldipine in the body more than 20-fold. grapefruit juice also increases nisoldipine concentrations by inhibiting cyp3a4. pharmacology mechanism of action further information: calcium channel blocker § mechanism of action nisoldipine is a calcium channel blocker that selectively inhibits l-type calcium channels.