rti-177 rti-177 rti(-4229)-177 (2β-(3-phenylisoxazol-5-yl)-3β-(4-chlorophenyl)tropane, β-cppit) is a synthetic stimulant drug from the phenyltropane family, which acts as a dri with micromolar affinity for the sert. rti-177 has an unusually long duration of action of 20 hours or more, substantially longer than the related compound rti-336 from which it differs in molecular structure only by the absence of a p-methyl group. rti-177identifiers iupac name (1r,2s,3s,5s)-3-(4-chlorophenyl)-8-methyl-2-(3-phenyl-1,2-oxazol-5-yl)-8-azabicyclooctane cas number171236-00-3hcl: 170939-95-4pubchem cid9821147chemspider7996896chemblchembl298580 ychemical and physical dataformulac23h23cln2omolar mass378.90 g·mol−13d model (jsmol)interactive image smiles cn12cc1((c2)c3=cc=c(c=c3)cl)c4=cc(=no4)c5=cc=cc=c5 inchi inchi=1s/c23h23cln2o/c1-26-18-11-12-21(26)23(19(13-18)15-7-9-17(24)10-8-15)22-14-20(25-27-22)16-5-3-2-4-6-16/h2-10,14,18-19,21,23h,11-13h2,1h3/t18-,19+,21+,23-/m0/s1key:zgcymnjhhkqega-kpyopsevsa-n "the nonselective monoamine transporter inhibitor rti-126 and the dat-selective inhibitors rti-150 and rti-336 both had a faster rate of onset (30 min) and a short duration of action (4h). in contrast, the nonselective monoamine transporter inhibitor rti-112 had a slower rate of onset (30–60 min) and a longer duration of action (10h). the dat-selective inhibitors rti-171 and rti-177 also had slower rates of onset (30–120 min), but rti-171 had a short duration of action (2.5 h) while rti-177 had a very long duration of action (20 h)." update lower reinforcing strength of the phenyltropane cocaine analogs rti-336 and rti-177 compared to cocaine in nonhuman primates. comparison of six mat inhibitors rti x r cft nisoxetine paroxetine coc — — 89.1 3298 (1986) 1045 (45) 177 cl phenyl 1.28 504 (304) 2420 (220) 176 me phenyl 1.58 398 (239) 5110 (465) 354 me ethyl 1.62 299 (180) 6400 (582) 336 cl p-cresyl 4.09 1714 (1033) 5741 (522) 386 me p-anisoyl 3.93 756 (450) 4027 (380) in the lindsey paper, rti-177 was wrongly considered to be a dual inhibitor of the net, although this was later found out to be incorrect. "in acute toxicity studies in male rats, 3β-(4-chlorophenyl)-2β-tropane (rti-336) possessed an ld50 of 180 mg/kg after oral administration, compared with 49 mg/kg for rti-177 (unpublished results, howell 2005; table 9). these results suggested that rti-336 was a better candidate than rti-177 for further preclinical development." also the potency of the heterocyclic compounds is not as great as would be predicted based on in vitro test results.