pinacidil pinacidil pinacidil is a cyanoguanidine drug that opens atp-sensitive potassium channels producing peripheral vasodilatation of arterioles. it reduces blood pressure and peripheral resistance and produces fluid retention. pinacidil names iupac name n-cyano-n'-pyridin-4-yl-n''-(1,2,2-trimethylpropyl)guanidine identifiers cas number 60560-33-0 (anhydrous) y85371-64-8 (monohydrate) y 3d model (jsmol) interactive image chembl chembl1159 nchembl1200338 n chemspider 4660 n echa infocard 100.056.614 iuphar/bps 2412 pubchem cid 4826 unii bb4ugo5k0d (anhydrous) y7b0zzh8p2w (monohydrate) y comptox dashboard (epa) dtxsid7048249 inchi inchi=1s/c13h19n5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10h,1-4h3,(h2,15,16,17,18) nkey: ivvnzdgdkptyhk-uhfffaoysa-n ninchi=1/c13h19n5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10h,1-4h3,(h2,15,16,17,18)key: ivvnzdgdkptyhk-uhfffaoyay smiles cc(c(c)(c)c)n=c(nc#n)nc1=cc=nc=c1 properties chemical formula c13h19n5 molar mass 245.32346 pharmacology atc code c02dg01 (who) except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). n verify (what is yn ?) infobox references synthesis thieme synthesis: patents: condensation of 4-isothiocyanotopyridine (1) and 3,3-dimethyl-2-butanamine (2) gives thiourea (3). treatment of that intermediate with a mixture of triphenylphosphine, carbon tetrachloride, and triethylamine leads to the unsymmetrical carbodiimide, cid:20501933 (4'). addition of cyanamid affords pinacidil (5).