thyroid disease thyroid disease thyroid disease is a medical condition that affects the function of the thyroid gland. the thyroid gland is located at the front of the neck and produces thyroid hormones that travel through the blood to help regulate many other organs, meaning that it is an endocrine organ. these hormones normally act in the body to regulate energy use, infant development, and childhood development. further information: thyroid disease in women thyroid diseasean illustration of goiter, a type of thyroid diseasespecialtyendocrinology, medical genetics there are five general types of thyroid disease, each with their own symptoms. a person may have one or several different types at the same time. the five groups are: hypothyroidism (low function) caused by not having enough free thyroid hormones hyperthyroidism (high function) caused by having too many free thyroid hormones structural abnormalities, most commonly a goiter (enlargement of the thyroid gland) tumors which can be benign (not cancerous) or cancerous abnormal thyroid function tests without any clinical symptoms (subclinical hypothyroidism or subclinical hyperthyroidism). in some types, such as subacute thyroiditis or postpartum thyroiditis, symptoms may go away after a few months and laboratory tests may return to normal. however most types of thyroid disease do not resolve on their own. common hypothyroid symptoms include fatigue, low energy, weight gain, inability to tolerate the cold, slow heart rate, dry skin and constipation. common hyperthyroid symptoms include irritability, anxiety, weight loss, fast heartbeat, inability to tolerate the heat, diarrhea, and enlargement of the thyroid. structural abnormalities may not produce symptoms, however some people may have hyperthyroid or hypothyroid symptoms related to the structural abnormality or notice swelling of the neck. rarely goiters can cause compression of the airway, compression of the vessels in the neck, or difficulty swallowing. tumors, often called thyroid nodules, can also have many different symptoms ranging from hyperthyroidism to hypothyroidism to swelling in the neck and compression of the structures in the neck. diagnosis starts with a history and physical examination. screening for thyroid disease in patients without symptoms is a debated topic although commonly practiced in the united states. if dysfunction of the thyroid is suspected, laboratory tests can help support or rule out thyroid disease. initial blood tests often include thyroid-stimulating hormone (tsh) and free thyroxine (t4). total and free triiodothyronine (t3) levels are less commonly used. if autoimmune disease of the thyroid is suspected, blood tests looking for anti-thyroid autoantibodies can also be obtained. procedures such as ultrasound, biopsy and a radioiodine scanning and uptake study may also be used to help with the diagnosis, particularly if a nodule is suspected. thyroid diseases are highly prevalent worldwide, and treatment varies based on the disorder. levothyroxine is the mainstay of treatment for people with hypothyroidism, while people with hyperthyroidism caused by graves' disease can be managed with iodine therapy, antithyroid medication, or surgical removal of the thyroid gland. thyroid surgery may also be performed to remove a thyroid nodule or to reduce the size of a goiter if it obstructs nearby structures or for cosmetic reasons. signs and symptoms symptoms of the condition vary with type: hypo- vs. hyperthyroidism, which are further described below. possible symptoms of hypothyroidism are: tiredness unexplained weight gain slow movement muscle cramps slow heart rate (bradycardia) sensitivity to cold temperatures constipation depressed mood memory difficultypossible symptoms of hyperthyroidism are: difficulty sleeping (insomnia) unexplained weight loss tremors fast heart rate (tachycardia) or palpitations sensitivity to hot temperatures, excess sweating diarrhea anxiety, irritabilitynote: certain symptoms and physical changes can be seen in both hypothyroidism and hyperthyroidism —fatigue, fine / thinning hair, menstrual cycle irregularities, muscle weakness / aches (myalgia), and different forms of myxedema. diseases low function main article: hypothyroidism hypothyroidism is a state in which the body is not producing enough thyroid hormones, or is not able to respond to / utilize existing thyroid hormones properly. the main categories are: thyroiditis: an inflammation of the thyroid gland hashimoto's thyroiditis / hashimoto's disease ord's thyroiditis postpartum thyroiditis silent thyroiditis acute thyroiditis riedel's thyroiditis (the majority of cases do not affect thyroid function, but approximately 30% of cases lead to hypothyroidism) iatrogenic hypothyroidism postoperative hypothyroidism medication- or radiation-induced hypothyroidism thyroid hormone resistance euthyroid sick syndrome congenital hypothyroidism: a deficiency of thyroid hormone from birth, which untreated can lead to cretinism high function exophthalmos is the eye bulging that may be seen with graves disease, one of the major causes of hyperthyroidism main article: hyperthyroidism hyperthyroidism is a state in which the body is producing too much thyroid hormone. the main hyperthyroid conditions are: graves' disease toxic thyroid nodule thyroid storm toxic nodular struma (plummer's disease) hashitoxicosis: transient hyperthyroidism that can occur in hashimoto's thyroiditis structural abnormalities endemic goiter goiter: an abnormal enlargement of the thyroid gland endemic goiter diffuse goiter multinodular goiter lingual thyroid thyroglossal duct cyst tumors thyroid cancer papillary follicular medullary anaplastic lymphomas are usually malignant thyroid adenomas are benign tumors medication side effects certain medications can have the unintended side effect of affecting thyroid function. while some medications can lead to significant hypothyroidism or hyperthyroidism and those at risk will need to be carefully monitored, some medications may affect thyroid hormone lab tests without causing any symptoms or clinical changes, and may not require treatment. the following medications have been linked to various forms of thyroid disease: amiodarone (more commonly can lead to hypothyroidism, but can be associated with some types of hyperthyroidism) lithium salts (hypothyroidism) some types of interferon and il-2 (thyroiditis) glucocorticoids, dopamine agonists, and somatostatin analogs (block tsh, which can lead to hypothyroidism) pathophysiology most thyroid disease in the united states stems from a condition where the body's immune system attacks itself. in other instances, thyroid disease comes from the body trying to adapt to environmental conditions like iodine deficiency or to new physiologic conditions like pregnancy. autoimmune thyroid disease autoimmune thyroid disease is a general category of disease that occurs due to the immune system targeting its own body. it is not fully understood why this occurs, but it is thought to be partially genetic as these diseases tend to run in families. in one of the most common types, grave's disease, the body produces antibodies against the tsh receptor on thyroid cells. this causes the receptor to activate even without tsh being present and causes the thyroid to produce and release excess thyroid hormone (hyperthyroidism). another common form of autoimmune thyroid disease is hashimoto thyroiditis where the body produces antibodies against different normal components of the thyroid gland, most commonly thyroglobulin, thyroid peroxidase, and the tsh receptor. these antibodies cause the immune system to attack the thyroid cells and cause inflammation (lymphocytic infiltration) and destruction (fibrosis) of the gland. goiter goiter is the general enlargement of the thyroid that can be associated with many thyroid diseases. the main reason this happens is because of increased signaling to the thyroid by way of tsh receptors to try to make it produce more thyroid hormone. this causes increased vascularity and increase in size (hypertrophy) of the gland. in hypothyroid states or iodine deficiency, the body recognizes that it is not producing enough thyroid hormone and starts to produce more tsh to help stimulate the thyroid to produce more thyroid hormone. this stimulation causes the gland to increase in size to increase production of thyroid hormone. in hyperthyroidism caused by grave's disease or toxic multinodular goiter, there is excess stimulation of the tsh receptor even when thyroid hormone levels are normal. in grave's disease this is because of an autoantibodies (thyroid stimulating immunoglobulins) which bind to and activate the tsh receptors in place of tsh while in toxic multinodular goiter this is often because of a mutation in the tsh receptor that causes it to activate without receiving a signal from tsh. in more rare cases, the thyroid may become enlarged because it becomes filled with thyroid hormone or thyroid hormone precursors that it is unable to release or because of congential abnormalities or because of increased intake of iodine from supplementation or medication. pregnancy there are many changes to the body during pregnancy. one of the major changes to help with the development of the fetus is the production of human chorionic gonadotropin (hcg). this hormone, produced by the placenta, has similar structure to tsh and can bind to the maternal tsh receptor to produce thyroid hormone. during pregnancy, there is also an increase in estrogen which causes the mother to produce more thyroxine binding globulin, which is what carries most of the thyroid hormone in the blood. these normal hormonal changes often make pregnancy look like a hyperthyroid state but may be within the normal range for pregnancy, so it necessary to use trimester specific ranges for tsh and free t4. true hyperthyroidism in pregnancy is most often caused by an autoimmune mechanism from grave's disease. new diagnosis of hypothyroidism in pregnancy is rare because hypothyroidism often makes it difficult to become pregnant in the first place. when hypothyroidism is seen in pregnancy, it is often because an individual already has hypothyroidism and needs to increase their levothyroxine dose to account for the increased thyroxine binding globulin present in pregnancy. diagnosis diagnosis of thyroid disease depends on symptoms and whether or not a thyroid nodule is present. most patients will receive a blood test. others might need an ultrasound, biopsy or a radioiodine scanning and uptake study. blood tests overview of the thyroid system and the various hormones involved. thyroid function tests further information: thyroid function tests there are several hormones that can be measured in the blood to determine how the thyroid gland is functioning. these include the thyroid hormones triiodothyronine (t3) and its precursor thyroxine (t4), which are produced by the thyroid gland. thyroid-stimulating hormone (tsh) is another important hormone that is secreted by the anterior pituitary cells in the brain. its primary function is to increase the production of t3 and t4 by the thyroid gland. the most useful marker of thyroid gland function is serum thyroid-stimulating hormone (tsh) levels. tsh levels are determined by a classic negative feedback system in which high levels of t3 and t4 suppress the production of tsh, and low levels of t3 and t4 increase the production of tsh. tsh levels are thus often used by doctors as a screening test, where the first approach is to determine whether tsh is elevated, suppressed, or normal. elevated tsh levels can signify inadequate thyroid hormone production (hypothyroidism) suppressed tsh levels can point to excessive thyroid hormone production (hyperthyroidism) because a single abnormal tsh level can be misleading, t3 and t4 levels must be measured in the blood to further confirm the diagnosis. when circulating in the body, t3 and t4 are bound to transport proteins. only a small fraction of the circulating thyroid hormones are unbound or free, and thus biologically active. t3 and t4 levels can thus be measured as free t3 and t4, or total t3 and t4, which takes into consideration the free hormones in addition to the protein-bound hormones. free t3 and t4 measurements are important because certain drugs and illnesses can affect the concentrations of transport proteins, resulting in differing total and free thyroid hormone levels. there are differing guidelines for t3 and t4 measurements. free t4 levels should be measured in the evaluation of hypothyroidism, and low free t4 establishes the diagnosis. t3 levels are generally not measured in the evaluation of hypothyroidism. free t4 and total t3 can be measured when hyperthyroidism is of high suspicion as it will improve the accuracy of the diagnosis. free t4, total t3 or both are elevated and serum tsh is below normal in hyperthyroidism. if the hyperthyroidism is mild, only serum t3 may be elevated and serum tsh can be low or may not be detected in the blood. free t4 levels may also be tested in patients who have convincing symptoms of hyper- and hypothyroidism, despite a normal tsh. antithyroid antibodies autoantibodies to the thyroid gland may be detected in various disease states. there are several anti-thyroid antibodies, including anti-thyroglobulin antibodies (tgab), anti-microsomal/anti-thyroid peroxidase antibodies (tpoab), and tsh receptor antibodies (tshrab). elevated anti-thryoglobulin (tgab) and anti-thyroid peroxidase antibodies (tpoab) can be found in patients with hashimoto's thyroiditis, the most common autoimmune type of hypothyroidism. tpoab levels have also been found to be elevated in patients who