jwh-081 jwh-081 jwh-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the cb1 and cb2 receptors. with a ki of 1.2nm it is fairly selective for the cb1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at cb2(12.4nm). it was discovered by and named after john w. huffman. jwh-081legal statuslegal status ca: schedule ii de: anlage ii (authorized trade only, not prescriptible) uk: class b us: schedule i i-n (poland) identifiers iupac name 4-methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone cas number210179-46-7 ypubchem cid10547208chemspider8722599unii77e58024itcomptox dashboard (epa)dtxsid80175225 echa infocard100.230.181 chemical and physical dataformulac25h25no2molar mass371.480 g·mol−13d model (jsmol)interactive image smiles cccccn3c1ccccc1c(c3)c(=o)c4c2ccccc2c(oc)cc4 inchi inchi=1s/c25h25no2/c1-3-4-9-16-26-17-22(19-11-7-8-13-23(19)26)25(27)21-14-15-24(28-2)20-12-6-5-10-18(20)21/h5-8,10-15,17h,3-4,9,16h2,1-2h3key:ubmpkjkguqdhrm-uhfffaoysa-n (verify) jwh-081 may be neurotoxic to animals when administered in high doses. legal status in the united states, jwh-081 is a schedule i controlled substance. as of october 2015, jwh-081 is a controlled substance in china.