alphacoronavirus alphacoronavirus alphacoronaviruses (alpha-cov) are members of the first of the four genera (alpha-, beta-, gamma-, and delta-) of coronaviruses. they are positive-sense, single-stranded rna viruses that infect mammals, including humans. they have spherical virions with club-shaped surface projections formed by trimers of the spike protein, and a viral envelope. this article is about the genus of coronavirus. it is not to be confused with the alpha variant of the sars-cov-2 virus that causes covid-19. alphacoronavirus porcine epidemic diarrhea virus genome and virion structure virus classification (unranked): virus realm: riboviria kingdom: orthornavirae phylum: pisuviricota class: pisoniviricetes order: nidovirales family: coronaviridae subfamily: orthocoronavirinae genus: alphacoronavirus subgenera and species see text alphacoronaviruses are in the subfamily orthocoronavirinae of the family coronaviridae. both the alpha- and betacoronavirus lineages descend from the bat viral gene pool. alphacoronaviruses were previously known as "phylogroup 1 coronaviruses". the alphacoronavirus genus is very diverse, particularly in bats. most bat originating strains haven't been successfully isolated and cultured in laboratory. alphacoronaviruses infecting other mammal species have been much better studied, see list of coronavirus live isolates. etymology the name alphacoronavirus is derived from ancient greek ἄλφα (álpha, "the first letter of the greek alphabet"), and κορώνη (korṓnē, "garland, wreath"), meaning crown, which describes the appearance of the surface projections seen under electron microscopy that resemble a solar corona. structure the virion is enveloped and spherical measuring 120–160 nm in diameter and a core shell of about 65 nm. glycoproteins and trimers form large surface projections which create the appearance of solar corona. this genus, like other coronaviruses, has a spike protein with a type i fusion machine (s2) and a receptor-binding domain (s1). it assembles into a trimer. unlike beta- and gammacoronaviruses, this protein is not cleaved into two halves. genome genetic relationships between the different feline coronaviruses (fcov) and canine coronaviruses (ccov) genotypes. recombination at arrows. the genome is positive-sense, single-stranded rna with a length of 27 to 29 kilobases and a 3'-polya tail. two large, overlapping orfs at the 5'-end of the genome encode the major non-structural proteins expressed as a fusion protein by ribosomal frameshift. these include regions with protease, helicase and rna polymerase motifs. there are seven other genes downstream which encode structural proteins. these are expressed from a 3'-coterminal nested set of subgenomic mrnas. recombination both types of alphacoronavirus 1, feline coronavirus (fcov) and canine coronavirus (ccov), are known to exist in two serotypes. serotype ii targets aminopeptidase n, while the receptor for serotype i is unknown. the difference is due to a different spike protein. there is a common ancestor for fcov and ccov. this ancestor gradually evolved into fcov i and ccov i. an s protein from an unknown virus was recombined into the ancestor and gave rise to ccov ii. ccov ii once again recombined with fcov to create fcov ii. ccov ii gradually evolved into tgev. a spike deletion in tgev creates prcv. all these viruses are sorted into the subgenus tegacovirus. classification phylogentic tree of the genus alphacoronaviruses with host animals indicated on the right hand side. the following subgenera and species are recognized: coronaviruses types alphacoronavirus betacoronavirus gammacoronavirus deltacoronavirus diseases common cold sars mers covid-19 vaccines covid-19 vaccine epidemics and pandemics sars (2002–2004) mers 2012 2015 2018 covid-19 (2019-present)