demegestone demegestone demegestone, sold under the brand name lutionex, is a progestin medication which was previously used to treat luteal insufficiency but is now no longer marketed. it is taken by mouth. demegestoneclinical datatrade nameslutionexother namesdimegestone; r-2453; ru-2453; 17α-methyl-δ9-19-norprogesterone; 17α-methyl-19-norpregna-4,9-diene-3,20-dioneroutes ofadministrationby mouthdrug classprogestogen; progestinatc codeg03db05 (who) pharmacokinetic databioavailabilitygoodmetabolismhydroxylation, othersmetabolites• 21-hydroxydemegestone• othersexcretionurineidentifiers iupac name (8s,13s,14s,17s)-17-acetyl-13,17-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopentaphenanthren-3-one cas number10116-22-0pubchem cid93057chemspider84009unii6e89am91szkeggd07223chebichebi:135339chemblchembl2104231comptox dashboard (epa)dtxsid20878581 echa infocard100.030.278 chemical and physical dataformulac21h28o2molar mass312.453 g·mol−13d model (jsmol)interactive image smiles cc(=o)1(cc21(ccc3=c4ccc(=o)c=c4cc23)c)c inchi inchi=1s/c21h28o2/c1-13(22)20(2)11-9-19-18-6-4-14-12-15(23)5-7-16(14)17(18)8-10-21(19,20)3/h12,18-19h,4-11h2,1-3h3/t18-,19+,20-,21+/m1/s1key:jwahbtqssmyisl-mhtwaqmvsa-n demegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. it has no androgenic activity. demegestone was first described in 1966 and was introduced for medical use in france in 1974. it has only been marketed in france, and has since been discontinued in this country. medical uses demegestone has been used to treat luteal insufficiency. it has also been studied in combination with estrogens, such as moxestrol, as an oral contraceptive and treatment for infertility. side effects