ws-12 ws-12 ws-12 is a chemical compound that acts as a potent and selective activator of the trpm8 calcium channel, which is responsible for the sensation of coldness produced by menthol. it is slightly less potent as a trpm8 activator compared to icilin, but is much more selective for trpm8 over related calcium channels. it produces analgesic and antiinflammatory effects in animal models with similar efficacy to menthol and a reduced side effect profile. ws-12 names preferred iupac name (1r,2s,5r)-n-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide identifiers cas number 68489-09-8 3d model (jsmol) interactive image chembl chembl2441929 chemspider 9441255 ec number 700-232-9 pubchem cid 11266244 unii 1l7bvt4z4z comptox dashboard (epa) dtxsid10460636 inchi inchi=1s/c18h27no2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17h,5,10-11h2,1-4h3,(h,19,20)/t13-,16+,17-/m1/s1key: hnsgvpaaxjjopq-xokhgstosa-n smiles c1cc((c1)c(=o)nc2=cc=c(c=c2)oc)c(c)c properties chemical formula c18h27no2 molar mass 289.419 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references