hyaloserositis hyaloserositis in pathology, hyaloserositis is the coating of an organ with a fibrous hyaline, resulting from inflammation of the serous membrane (serositis) covering the organ. micrograph of hyaloserositis of the spleen (sugar-coated spleen). h&e stain. the spleen is commonly affected and often referred to as sugar-coated spleen. the liver and heart are also sometimes affected and referred to as frosted liver (or sugar-coated liver) and frosted heart respectively. hyaloserositis of the spleen is usually considered benign, i.e. it does not necessitate any treatment.