butriptyline butriptyline butriptyline, sold under the brand name evadyne among others, is a tricyclic antidepressant (tca) that has been used in the united kingdom and several other european countries for the treatment of depression but appears to no longer be marketed. along with trimipramine, iprindole, and amoxapine, it has been described as an "atypical" or "second-generation" tca due to its relatively late introduction and atypical pharmacology. it was very little-used compared to other tcas, with the number of prescriptions dispensed only in the thousands. butriptylineclinical datatrade namesevadyne, othersother namesay-62014routes ofadministrationoralatc coden06aa15 (who) legal statuslegal status in general: ℞ (prescription only) pharmacokinetic databioavailability?protein binding>90%metabolismhepatic (n-demethylation)metabolitesnorbutriptylineelimination half-life20 hoursidentifiers iupac name (±)-3-(10,11-dihydro-5h-dibenzocycloheptene-5-yl)-n,n,2-trimethylpropan-1-amine cas number35941-65-2 yhcl: 5585-73-9 ypubchem cid21772drugbankdb09016 nchemspider20462 yuniiz22441975xhcl: lij2h8658w ykeggd07601 ychebichebi:135227 ychemblchembl2110816 ncomptox dashboard (epa)dtxsid6022715 chemical and physical dataformulac21h27nmolar mass293.454 g·mol−13d model (jsmol)interactive imagechiralityracemic mixture smiles c1cc3c(cc1)ccc2c(cccc2)c3cc(c)cn(c)c inchi inchi=1s/c21h27n/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21/h4-11,16,21h,12-15h2,1-3h3 ykey:aleltfcqzdxamq-uhfffaoysa-n y ny (what is this?) (verify) medical uses butriptyline was used in the treatment of depression. it was usually used at dosages of 150–300 mg/day. side effects butriptyline is closely related to amitriptyline, and produces similar effects as other tcas, but its side effects like sedation are said to be reduced in severity and it has a lower risk of interactions with other medications. butriptyline has potent antihistamine effects, resulting in sedation and somnolence. it also has potent anticholinergic effects, resulting in side effects like dry mouth, constipation, urinary retention, blurred vision, and cognitive/memory impairment. the drug has relatively weak effects as an alpha-1 blocker and has no effects as a norepinephrine reuptake inhibitor, so is associated with little to no antiadrenergic and adrenergic side effects. overdose main article: tricyclic antidepressant overdose pharmacology pharmacodynamics