pregnenolone acetate pregnenolone acetate pregnenolone acetate (brand names antofin, previsone, pregno-pan), also known as pregn-5-en-3β-ol-20-one 3β-acetate, is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and as a skin-conditioning and skin anti-aging agent. it has been reported to reduce wrinkles in elderly women when applied in the form of a 0.5% topical cream, effects which were suggested to be due to improved hydration of the skin. pregnenolone acetate has been marketed in france in a topical cream containing 1% pregnenolone acetate and 10% "sex hormone" for the treatment of premature skin aging but was withdrawn from the market in 1992. although the medication has been described by some sources as a glucocorticoid, other authors have stated that systemic pregnenolone acetate has no undesirable metabolic or toxic effects even at high doses. pregnenolone acetateclinical datatrade namesantofin, previsone, pregno-panother namespregn-5-en-3β-ol-20-one 3β-acetate, antofin, artivis, enescorb, previsone, sharmone, pregnenolone-3-acetate, 1778-02-5, 3α-acetoxy-5-pregnen-20-one, zinc6304690, nsc 64827, acetic acid 20-oxopregn-5-en-3alpha-yl esterroutes ofadministrationtopicalidentifiers iupac name phenanthren-3-yl] acetate cas number1778-02-5pubchem cid2723722drugbankdb14626chemspider2005918unii0g0wwv404bkeggc14658chebichebi:34930chemblchembl1892286comptox dashboard (epa)dtxsid3048942 echa infocard100.015.648 chemical and physical dataformulac23h34o3molar mass358.522 g·mol−13d model (jsmol)interactive image smiles cc(=o)1cc21(cc32cc=c43(cc(c4)oc(=o)c)c)c inchi inchi=1s/c23h34o3/c1-14(24)19-7-8-20-18-6-5-16-13-17(26-15(2)25)9-11-22(16,3)21(18)10-12-23(19,20)4/h5,17-21h,6-13h2,1-4h3/t17-,18-,19+,20-,21-,22-,23+/m0/s1key:crrkvzvyzqxicq-rjjcnjevsa-n