allenolic acid allenolic acid allenolic acid, or allenoic acid, is a synthetic, nonsteroidal estrogen discovered in 1947 or 1948 that, although studied clinically, was never marketed. it is an open-ring or seco-analogue of steroidal estrogens like estrone and equilenin. the compound was named after edgar allen, one of the pioneers in estrogen research. although described as an estrogen, allenolic acid probably is totally inactive at the receptor, whereas a derivative, allenestrol (α,α-dimethyl-β-ethylallenolic acid), is reported to be a potent estrogen. another derivative of allenolic acid (specifically 6-methoxy-allenestrol), methallenestril (brand name vallestril), is also a potent estrogen and, in contrast to allenolic acid and allenestrol, has been marketed. allenolic acididentifiers iupac name 3-(6-hydroxynaphthalen-2-yl)propanoic acid cas number553-39-9pubchem cid96227chemspider86868uniii2mqt1cc3hchebichebi:34529comptox dashboard (epa)dtxsid10203823 chemical and physical dataformulac13h12o3molar mass216.236 g·mol−13d model (jsmol)interactive image smiles c1=cc2=c(c=cc(=c2)o)c=c1ccc(=o)o inchi inchi=1s/c13h12o3/c14-12-5-4-10-7-9(2-6-13(15)16)1-3-11(10)8-12/h1,3-5,7-8,14h,2,6h2,(h,15,16)key:nhgxznwpadxvoa-uhfffaoysa-n