lipoblast lipoblast a lipoblast is a precursor cell for an adipocyte. histopathology of liposarcoma, h&e stain, with the main features:- spindle cells with enlarged, hyperchromatic nuclei.- apparently univacuolated adipocytes (may look normal).- lipoblasts (multivacuolated), but neither necessary nor sufficient for diagnosis of liposarcoma. alternate terms include adipoblast and preadipocyte. early stages are almost indistinguishable from fibroblasts. lipoblasts (white arrow) and lipocytes (black arrow), in a case of lipoblastoma micrograph showing a lipoblast (left-bottom of image) in a liposarcoma. h&e stain. liposarcoma lipoblasts are seen in liposarcoma and characteristically have abundant multivacuolated clear cytoplasm and a dark staining (hyperchromatic), indented nucleus.