amyotrophy amyotrophy amyotrophy is progressive wasting of muscle tissues. muscle pain is also a symptom. it can occur in middle-aged males with type 2 diabetes. it also occurs with motor neuron disease. amyotrophyspecialtyneurology differential diagnosis the following are considered differential diagnosis for amyotrophy: compressive and infective causes of polyradiculopathy structural disc diseases chronic demyelinating neuropathies