lelis syndrome lelis syndrome lelis syndrome is a genetic disorder, a rare condition with dermatological and dental findings characterized by the association of ectodermal dysplasia (hypotrichosis and hypohidrosis) with acanthosis nigricans. other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual deficit, disturbances of skin pigmentation (perioral and periorbital hyperpigmentation, vitiligo, and perinevic leukoderma) and hypodontia. transmission is autosomal recessive. lelis syndromeother namesectodermal dysplasia-acanthosis nigricans syndromethis condition is inherited in an autosomal recessive manner.