profadol profadol profadol (ci-572) is an opioid analgesic which was developed in the 1960s by parke-davis. it acts as a mixed agonist-antagonist of the μ-opioid receptor. the analgetic potency is about the same as of pethidine (meperidine), the antagonistic effect is 1/50 of nalorphine. not to be confused with propanol, propofol, or propranolol. profadolclinical dataatc codenonelegal statuslegal status us: analogue to a schedule i/ii drug (analogue of tapentadol, schedule ii) identifiers iupac name 3-(1-methyl-3-propyl-pyrrolidin-3-yl)phenol cas number428-37-5pubchem cid9882chemspider9498unii41gdg43fttchemblchembl161204chemical and physical dataformulac14h21nomolar mass219.328 g·mol−1 synthesis synthesis: patents: the knoevenagel condensation between 3'-methoxybutyrophenone and ethyl cyanoacetate gives (1). conjugate addition of cyanide gives (2). hydrolysis of both nitrile groups, saponification of the ester and decarboxylation gives the diacid, cid:164137621 (3). imide formation occurs upon treatment with methylamine giving 3-(3-methoxyphenyl)-1-methyl-3-propylpyrrolidine-2,5-dione, cid:163444474 (4). reduction of the imide by lithium aluminium hydride gave (5). demethylation completed the synthesis of profadol (6).