zuclomifene zuclomifene zuclomifene (inn; or zuclomiphene (usan)) is a nonsteroidal selective estrogen receptor modulator (serm) of the triphenylethylene group that was never marketed. it is one of the two stereoisomers of clomifene, which itself is a mixture of 38% zuclomifene and 62% enclomifene. zuclomifene is the (z)-stereoisomer of clomifene, while enclomifene is the (e)-stereoisomer. whereas zuclomifene is described as mildly estrogenic, enclomifene is described as antiestrogenic. in accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the estrogen receptor and reduces testosterone levels in men. it is also about five times more potent than enclomifene in inducing ovulation. zuclomifeneclinical dataother nameszuclomiphene; trans-clomifene; transclomiphene; (z)-clomifene; ici-46476; rmi-16312; zuclomifene citrate; zuclomiphene citrateroutes ofadministrationoralidentifiers iupac name 2-phenoxy]-n,n-diethylethanamine cas number15690-55-8pubchem cid1548955chemspider1265969unii3ju1du3652keggd09037chemical and physical dataformulac26h28clnomolar mass405.97 g·mol−13d model (jsmol)interactive image smiles ccn(cc)ccoc1=cc=c(c=c1)/c(=c(/c2=cc=cc=c2)\cl)/c3=cc=cc=c3 inchi inchi=1s/c26h28clno/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18h,3-4,19-20h2,1-2h3/b26-25-key:gkirpkyjqbwngo-qplcgjkrsa-n