amg-517 amg-517 amg-517 is a drug which acts as a potent and selective blocker of the trpv1 ion channel. it was developed as a potential treatment for chronic pain, but while it was an effective analgesic in animal studies it was dropped from human clinical trials at phase i due to producing hyperthermia as a side effect, as well as poor water solubility. it is still used in scientific research into the function of the trpv1 channel and its role in pain and inflammation, and has been used as a template for the design of several newer analogues which have improved properties. amg-517identifiers iupac name n-(4-oxy-1,3-benzothiazol-2-yl)acetamide cas number659730-32-2pubchem cid16007367chemspider10609411unii172v4fbz75chemblchembl229430comptox dashboard (epa)dtxsid90216178 chemical and physical dataformulac20h13f3n4o2smolar mass430.41 g·mol−13d model (jsmol)interactive image smiles cc(=o)nc1=nc2=c(c=cc=c2s1)oc3=nc=nc(=c3)c4=cc=c(c=c4)c(f)(f)f inchi inchi=1s/c20h13f3n4o2s/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10h,1h3,(h,26,27,28)key:yutixvxzqiqwgy-uhfffaoysa-n