benproperine benproperine benproperine (inn) is a cough suppressant. it has been marketed in multiple countries in central america and europe, as the phosphate or pamoate salts in either tablet, dragée, or syrup form. trade names include blascorid in italy and sweden, pectipront and tussafug in germany, and pirexyl in scandinavia. the recommended dosage for adults is 25 to 50 mg two to four times daily, and for children 25 mg once or twice daily. adverse effects include dry mouth, dizziness, fatigue, and heartburn. benproperineclinical datatrade namesblascorid, pectipront, pirexyl, tussafugahfs/drugs.cominternational drug namesatc coder05db02 (who) identifiers iupac name (rs)-1-piperidine cas number2156-27-6 y 19428-14-9 (phosphate salt)pubchem cid2326chemspider2236 yunii3aa6iz48ykkeggd07512 ychemblchembl2105910comptox dashboard (epa)dtxsid10862853 chemical and physical dataformulac21h27nomolar mass309.453 g·mol−13d model (jsmol)interactive image smiles o(c1ccccc1cc2ccccc2)cc(n3ccccc3)c inchi inchi=1s/c21h27no/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19/h2,4-7,10-13,18h,3,8-9,14-17h2,1h3 ykey:jtuqxgzrvlwbcr-uhfffaoysa-n y (verify) synthesis thieme patents: revised: china: the base catalyzed ether formation between 2-benzylphenol (1) and 1,2-dichloropropane (2) gives 1-benzyl-2-(2-chloropropoxy)benzene (3). displacement of the remaining halogen with piperidine completes the synthesis of benproperine (4).