lztfl1 lztfl1 leucine zipper transcription factor like 1 also known as lztfl1 is a ubiquitously expressed protein which localizes to the cytoplasm and in humans is encoded by the lztfl1 gene. lztfl1identifiersaliaseslztfl1, bbs17, leucine zipper transcription factor like 1external idsomim: 606568 mgi: 1934860 homologene: 41368 genecards: lztfl1 gene location (human)chr.chromosome 3 (human)band3p21.31start45,823,316 bpend45,916,042 bpgene location (mouse)chr.chromosome 9 (mouse)band9 f4|9 74.36 cmstart123,523,481 bpend123,546,762 bprna expression patternbgeehumanmouse (ortholog)top expressed inbronchial epithelial cellspermbrodmann area 23caput epididymisendothelial cellmiddle temporal gyrusachilles tendoncorpus epididymismetanephric glomeruluskidney tubuletop expressed inspermatidspermatocyteseminiferous tubulesecondary oocyteolfactory epitheliumthymusparotid glandbelly cordvas deferenspineal glandmore reference expression databiogpsn/agene ontologymolecular function protein binding identical protein binding protein-containing complex binding cellular component cytoplasm cytosol biological process negative regulation of protein localization to cilium negative regulation of protein localization to ciliary membrane sources:amigo / quickgoorthologsspecieshumanmouseentrez5458593730ensemblensg00000163818ensmusg00000025245uniprotq9nq48q9jhq5refseq (mrna)nm_001276378nm_001276379nm_020347nm_001386451nm_001386452nm_033322refseq (protein)np_001263307np_001263308np_065080np_201579location (ucsc)chr 3: 45.82 – 45.92 mbchr 9: 123.52 – 123.55 mbpubmed searchwikidataview/edit humanview/edit mouse function this protein regulates protein trafficking to the ciliary membrane through interaction with the bardet-biedl syndrome (bbs) complex of proteins. clinical significance mutations in the lztfl1 gene are associated with bardet-biedl syndrome, and the gene also acts as a tumor suppressor through regulation of epithelial-mesenchymal transition. identified as the gene on chromosome 3 at location 3p21.31 responsible for mediating an associated with genetic susceptibility to sars-cov-2 infection and covid-19 respiratory failure. the dna segment conferring the risk is inherited from neanderthals.