nubp2 nubp2 nucleotide-binding protein 2 (nbp 2) also known as cytosolic fe-s cluster assembly factor nubp2 is a protein that in humans is encoded by the nubp2 gene. nubp2identifiersaliasesnubp2, cfd1, nbp 2, nubp1, nucleotide binding protein 2, ciao6, nubp iron-sulfur cluster assembly factor 2, cytosolicexternal idsomim: 610779 mgi: 1347072 homologene: 8057 genecards: nubp2 gene location (human)chr.chromosome 16 (human)band16p13.3start1,782,932 bpend1,789,186 bpgene location (mouse)chr.chromosome 17 (mouse)band17 a3.3|17 12.53 cmstart24,882,611 bpend24,886,349 bprna expression patternbgeehumanmouse (ortholog)top expressed inthymusright lobe of liverfundusbody of pancreasright adrenal glandgastrocnemius musclebody of stomachskin of abdomenprostatepituitary glandtop expressed inspermatocyteseminiferous tubulespermatidmorulayolk sacblastocystproximal tubuleotic placodethymusprimitive streakmore reference expression databiogpsn/agene ontologymolecular function 4 iron, 4 sulfur cluster binding iron-sulfur cluster binding protein binding atp binding metal ion binding nucleotide binding cellular component cytoplasm centriole cell projection spindle pole centrosome cilium cytoskeleton nucleus microtubule organizing center cytosol biological process cell projection organization iron-sulfur cluster assembly sources:amigo / quickgoorthologsspecieshumanmouseentrez1010126426ensemblensg00000095906ensmusg00000039183uniprotq9y5y2q9r061refseq (mrna)nm_001284501nm_001284502nm_012225nm_011956nm_001355396refseq (protein)np_001271430np_001271431np_036357np_036086np_001342325location (ucsc)chr 16: 1.78 – 1.79 mbchr 17: 24.88 – 24.89 mbpubmed searchwikidataview/edit humanview/edit mouse para/mind atpase likeidentifierssymbolparapfampf10609interproipr019591available protein structures:pfam structures / ecod pdbrcsb pdb; pdbe; pdbjpdbsumstructure summary nubp2 is a member of the nubp/mrp gene subfamily of atp-binding proteins. there are two types in eukaryotes nubp1 and nubp2, and one novel human gene that define nbp nucleotide-binding proteins (nubp/mrp-multidrug resistance-associated protein) in mammalian cells requires the maturation of cytosolic iron-sulfur (fe/s) proteins as nubp1 is involved in the formation of extramitochondrial fe/s proteins the cell division inhibitor mind is homologous and involve two proteins components of the (fes) protein assembly machinery closely similar cytosolic soluble p loop ntpase where nar1 is required for assembly, identified cfd1p in cytosolic and nuclear fe/s protein biogenesis in yeast. nubp proteins ntpase nbp35p. mind is homologous to members in mind of e. coli, a relative of the para family. morphology further information: morphology (biology) nbp35 bacterial plasmids f (the classical escherichia coli sex factor) is found in all nuclear genes in vegetative and gametic flagella of the unicellular green algae c. reinhardtii and nuclear fe/s protein biogenesis required for cytosolic iron-sulfur protein assembly; mnp =mrp-like; mrp (multiple resistance and ph adaptation) mrp/nbp35-like p-loop ntpase similar to; and functions as mind_arch; cell division atpase mind, archaeal and homologue's of nubp1. the nbp35 gene is conserved in archaea bacteria, metazoa, fungi and other eukaryotes and with considerable divergence from the yeast; cfd1-nbp35 fe-s to man. in a scaffold complex protein to form large molecular assemblies that store fe(iii) and 4fe-4s seen as secondary to defects inactivated to accomplish its functions as physiologically relevant form(s) fe/s proteins iron regulatory protein 1 (irp1) is regulated through prevents deficiencies and increased mutation rates that characterized a plant p loop ntpase with sequence similarity to nbp35 homologue's of nubp1. interactions nubp2 has been shown to interact with... aco1 iron-responsive element-binding protein 1 (ire-bp 1) (iron regulatory protein 1) (irp1) mapk8ip3 c-jun-amino-terminal kinase-interacting protein 3 (jnk-interacting protein 3) (jip-3) igfals insulin-like growth factor-binding protein complex acid labile chain precursor (als) kif11 kinesin-like protein kif11 (kinesin-related motor protein eg5) sepp1 selenoprotein p precursor (sep) ca1 carbonic anhydrase 1 (ec 4.2.1.1) (carbonic anhydrase i) (carbonate dehydratase i) (ca-i)