demexiptiline demexiptiline demexiptiline (brand names deparon, tinoran) is a tricyclic antidepressant (tca) used in france for the treatment of depression. it acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine. demexiptilineclinical datatrade namesdeparon, tinoranroutes ofadministrationoralatc codenonelegal statuslegal status in general: ℞ (prescription only) pharmacokinetic dataelimination half-life35 hoursidentifiers iupac name 5h-dibenzo(a,d)cyclohepten-5-one o-(2-(methylamino)ethyl)oxime cas number24701-51-7 ypubchem cid28876drugbankdb08998 ychemspider26858uniieyx738uz5pchemblchembl2107576comptox dashboard (epa)dtxsid40179441 chemical and physical dataformulac18h18n2omolar mass278.355 g·mol−13d model (jsmol)interactive image smiles o(\n=c3/c1ccccc1\c=c/c2c3cccc2)ccnc synthesis the synthesis is similar to that reported for noxiptiline but also differs in a couple of respects. synthesis: patents: the condensation between dibenzosuberenone (1) and hydroxylamine (2) gives the oxime, (3). base catalyzed attachment of the sidechain by reaction with 2-chloro-n-methylethanamine (4) completed the synthesis of demexiptiline (5).