carbinoxamine carbinoxamine carbinoxamine is an antihistamine and anticholinergic agent. it is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. carbinoxamine is a histamine antagonist, specifically an h1-antagonist. the maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine. carbinoxamineclinical datatrade namesclistin, othersahfs/drugs.commonographmedlineplusa606008pregnancycategory c routes ofadministrationoral: 4 mg tablet or 4 mg/5 ml liquidatc coder06aa08 (who) legal statuslegal status us: 4 mg is fda approved in general: over-the-counter (otc) pharmacokinetic dataelimination half-life10 to 20 hoursidentifiers iupac name 2--n,n-dimethyl-ethanamine cas number486-16-8 ymaleate salt: 3505-38-2 ypubchem cid2564iuphar/bps7139drugbankdb00748 ychemspider2466 yunii982a7m02h5maleate salt: 02o55696wh ykeggd07617 ychebichebi:3398 ychemblchembl864 ycomptox dashboard (epa)dtxsid4022737 echa infocard100.006.935 chemical and physical dataformulac16h19cln2omolar mass290.79 g·mol−13d model (jsmol)interactive image smiles clc1ccc(cc1)c(occn(c)c)c2ncccc2 inchi inchi=1s/c16h19cln2o/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16h,11-12h2,1-2h3 ykey:ojfsxzcbgqgrnv-uhfffaoysa-n y (verify) it was patented in 1947 and came into medical use in 1953. it was first launched in the united states by the mcneil corporation under the brand name clistin. carbinoxamine is available in various countries around the world by itself, combined with decongestants such as pseudoephedrine, and also with other ingredients including paracetamol, aspirin, and codeine. society and culture in june 2006 the fda announced that more than 120 branded pharmacy products containing carbinoxamine were being illegally marketed and demanded they be removed from the marketplace. this action was precipitated by twenty-one reported deaths in children under the age of two who had been administered carbinoxamine-containing products. despite the fact that the drug had not been studied in this age group, a multitude of otc preparations containing carbinoxamine were being marketed for infants and toddlers. at present, all carbinoxamine-containing formulations are approved only for adults or children ages 3 or older. brand names brand names include clistin, palgic, rondec, rhinopront, ryvent. side effects continuous and/or cumulative use of anticholinergic medication, including first-generation antihistamines, is associated with a higher risk of cognitive decline and dementia in older people.