vesiculobullous disease vesiculobullous disease a vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters). both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used). in the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. examples of vesiculobullous diseases include: infectious: (viral) herpes simplex varicella-zoster infection hand, foot and mouth disease herpangina measles (rubeola) immunobullous: pemphigus vulgaris pemphigoid dermatitis herpetiformis linear immunoglobulin-a disease (linear iga disease) genetic: epidermolysis bullosa vesiculobullous diseasediagram showing cross section of vesicles (left) and bullae (right) on skin.specialtydermatology some features are as follows: name acantholysis? ig epidermolysis bullosa yes mostly igg bullous pemphigoid no mostly igg dermatitis herpetiformis no iga