hyperproinsulinemia hyperproinsulinemia hyperproinsulinemia is a disease where insulin is not sufficiently processed before secretion and immature forms of insulin make up the majority of circulating insulin immunoreactivity in both fasting and glucose-stimulated conditions (insulin immunoreactivity refers to all molecules detectable by an insulin antibody, i.e. insulin, proinsulin, and proinsulin-like material). the term is composed of hyper - high, proinsulin - immature insulin molecule, and -emia - blood condition. hyperproinsulinemiathis condition is inherited in an autosomal dominant manner. hyperproinsulinemia is more frequent in type 2 diabetes. it has been attributed to either a direct β-cells defect or an indirect effect of cell dysregulation under sustained elevated blood glucose (hyperglycemia). some alleles of insulin can cause hyperproinsulinemia (see table 2: monogenic forms of type 1 diabetes, ins (insulin). for a more detailed descriptions of the insulin gene variations leading to hyperproinsulinemia see ncbi's omim 176730