granuloma faciale granuloma faciale granuloma faciale is an uncommon benign chronic skin disease of unknown origin characterized by single or multiple cutaneous nodules, usually occurring over the face.: 836 occasionally, extrafacial involvement is noted, most often on sun-exposed areas. granuloma facialeother namesgfspecialtydermatology diagnosis skin biopsy for histopathology: focal lcv, diffuse dermal neutrophilia with leukocytoclasia, tissue eosinophilia & perivascular fibrosis. differential diagnosis the disease mimics many other dermatoses and can be confused with conditions, such as sarcoidosis, discoid lupus erythematosus, mycosis fungoides, and fixed drug eruption. treatment topical corticosteroid, intralesional corticosteroid, dapsone, colchicine, antimalarial, pulse dye laser, carbon dioxide laser. history gf was first described in 1945 by john edwin mackonochie wigley (1892–1962).