hypertension and brachydactyly syndrome hypertension and brachydactyly syndrome hypertension and brachydactyly syndrome (htnb), also known as bilginturan syndrome and brachydactyly type e among others, is a very rare genetic disorder. hypertension and brachydactyly syndromeother namesbrachydactyly-arterial hypertension syndromethis condition is inherited in an autosomal dominant manner. it was first reported in 1973 by n. bilginturan et al. the estimated prevalence is less than 1 out of 1,000,000. symptoms the disorder is characterized by: severe salt-independent but age-dependent hypertension brachydactyly malformations of the hands and fingers increased fibroblast growth rate neurovascular contact at the rostral-ventrolateral medulla altered baroreflex blood pressure regulation death from stroke before age 50 years when untreated genetics the disorder is thought to be related to mutations in the pde3a gene.