skf-81,297 skf-81,297 skf-81,297 is a synthetic drug of the benzazepine chemical class that acts as a selective dopamine d1/d5 receptor full agonist, and produces a characteristic stimulant-like pattern of anorexia, hyperactivity and self-administration in animals. this profile is shared with several related drugs such as 6-br-apb and skf-82,958, but not with certain other d1 full agonists such as a-77,636, reflecting functional selectivity of d1 activation. newer findings reveal that skf-81,297 additionally acts as a partial agonist at d1-d2 receptor heteromers. skf-81,297clinical dataatc codenoneidentifiers iupac name 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1h-benzoazepine-7,8-diol cas number253446-15-0 ypubchem cid16219952chemspider1181uniij494dh8jrccomptox dashboard (epa)dtxsid3058743 chemical and physical dataformulac16h16clno2molar mass289.76 g·mol−13d model (jsmol)interactive image smiles clc1c(o)c(o)cc2c1ccncc2c3ccccc3 one of the patented uses for skf-81,297 is as an augmentation agent when combined with an appropriate choice of an antidepressant.