benperidol benperidol benperidol, sold under the trade name anquil among others, is a typical antipsychotic primarily used to treat hypersexuality syndromes and can be used to treat schizophrenia. it is a highly potent butyrophenone derivative and is the most potent neuroleptic in the european market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% the potency per dose of haloperidol). it is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate. benperidolclinical datatrade namesanquil, frenactilahfs/drugs.cominternational drug namesroutes ofadministrationoralatc coden05ad07 (who) legal statuslegal status au: s4 (prescription only) us: ℞-only pharmacokinetic dataelimination half-life8 hoursidentifiers iupac name 1--1,3-dihydro-2h-benzimidazol-2-one cas number2062-84-2 npubchem cid16363drugbankdb12867 ychemspider15521 yunii97o6x78c53keggd02627chebichebi:93403chemblchembl297302 ycomptox dashboard (epa)dtxsid7045364 echa infocard100.016.521 chemical and physical dataformulac22h24fn3o2molar mass381.451 g·mol−13d model (jsmol)interactive image smiles fc1ccc(cc1)c(=o)cccn4ccc(n3c2ccccc2nc3=o)cc4 inchi inchi=1s/c22h24fn3o2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18h,3,6,11-15h2,(h,24,28) ykey:febotphfxyhvpl-uhfffaoysa-n y ny (what is this?) (verify) benperidol was discovered by janssen pharmaceutica in 1961 and has been marketed since 1966. it is mainly used in germany, but it is also available in belgium, greece, italy, the netherlands, and the united kingdom. pharmacology pharmacodynamics benperidol is a strong dopamine receptor antagonist (d2 (ki 0.027 nm) and d4 (ki 0.066 nm)) with weaker serotonin receptor antagonism (5-ht2a (ki 3.75 nm)). in high doses, it has antihistaminergic and alpha-adrenergic properties. it possesses minimal anticholinergic properties. benperidol siteki (nm)actionref 5-ht2a3.75antagonist d14,100antagonist d20.027antagonist d40.06antagonist pharmacokinetics benperidol is absorbed well and undergoes extensive first pass metabolism. one percent of benperidol is excreted in urine. the half-life of benperidol is 8 hours. synthesis thieme patent: 4-(2-keto-1-benzimidazolinyl)piperidine (1) is alkylated with 4-chloro-4'-fluorobutyrophenone (2).