salicylamide salicylamide salicylamide (o-hydroxybenzamide or amide of salicyl) is a non-prescription drug with analgesic and antipyretic properties. its medicinal uses are similar to those of aspirin. salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedy painaid. it was also an ingredient in the over-the-counter pain remedy bc powder but was removed from the formulation in 2009, and excedrin used the ingredient from 1960 to 1980 in conjunction with aspirin, acetaminophen, and caffeine. it was used in later formulations of vincent's powders in australia as a substitute for phenacetin. pure salicylamide is a white or slightly pink crystalline powder salicylamideclinical datamedlineplusa681004atc coden02ba05 (who) n02ba55 (who) (combinations)pharmacokinetic dataexcretionrenalidentifiers iupac name 2-hydroxybenzamide cas number65-45-2 ypubchem cid5147drugbankdb08797 ychemspider4963 yuniiem8bm710zcchebichebi:32114 ychemblchembl27577 yniaid chemdb018403comptox dashboard (epa)dtxsid3021726 echa infocard100.000.554 chemical and physical dataformulac7h7no2molar mass137.138 g·mol−13d model (jsmol)interactive imagedensity1.33 g/cm3solubility in watersoluble in hot water, ether, alcohol, and chloroform. mg/ml (20 °c) smiles o=c(c1ccccc1o)n inchi inchi=1s/c7h7no2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9h,(h2,8,10) ykey:skzkkfzagnvimn-uhfffaoysa-n y (verify) derivatives derivatives of salicylamide include ethenzamide, labetalol, medroxalol, lopirin, otilonium, oxyclozanide, salicylanilide, niclosamide, and raclopride.