abecarnil abecarnil abecarnil (zk-112,119) is an anxiolytic drug from the β-carboline family. it is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. it is a partial agonist acting selectively at the benzodiazepine site of the gabaa receptor. abecarnilclinical dataatc codenonepharmacokinetic dataelimination half-life3.4 hours (iv), 7 hours (oral)identifiers iupac name propan-2-yl 4-(methoxymethyl)-6-(phenylmethoxy) -9h-pyridoindole-3-carboxylate cas number111841-85-1 npubchem cid65914chemspider59323 yuniiizm1pnj3jlkeggd02594 ychemblchembl454095 ycomptox dashboard (epa)dtxsid40149745 chemical and physical dataformulac24h24n2o4molar mass404.466 g·mol−13d model (jsmol)interactive image smiles cocc3c(c(=o)oc(c)c)ncc4c2ccc(occ1ccccc1)cc2c34 inchi inchi=1s/c24h24n2o4/c1-15(2)30-24(27)23-19(14-28-3)22-18-11-17(29-13-16-7-5-4-6-8-16)9-10-20(18)26-21(22)12-25-23/h4-12,15,26h,13-14h2,1-3h3 ykey:rlfkilxoljvunf-uhfffaoysa-n y (verify) abecarnil was originally developed as an anti-anxiety drug, but has not as yet been commercially developed for use in humans, instead so far mainly being used for research into the development of other new sedative and anxiolytic drugs. investigations are continuing into its actions and it looks likely to be developed for use both in the treatment of anxiety, and as a less addictive substitute drug for the treatment of benzodiazepine and alcohol addiction. abecarnil may also have fewer problems of tolerance and withdrawal problems compared to nonselective full agonist benzodiazepine acting drugs. abecarnil is a relatively subtype-selective drug which produces primarily anxiolytic effects, with comparatively less sedative or muscle relaxant properties, and does not significantly potentiate the effects of alcohol. the abuse potential of abecarnil is thought to be less than that of benzodiazepines, with only mild withdrawal symptoms noted after abrupt discontinuation of treatment.