iotrolan iotrolan iotrolan (trade name isovist) is an iodine-containing radiocontrast agent, a substance used to improve the visibility of body structures on images obtained by x-ray techniques. iotrolanclinical datatrade namesisovistahfs/drugs.cominternational drug namespregnancycategory contraindicated atc codev08ab06 (who) legal statuslegal status in general: ℞ (prescription only) pharmacokinetic dataprotein bindingnegligibleexcretion99% via kidneysidentifiers iupac name 2,4,6-triiodo-5-)carbamoyl]acetamido}-1-n,3-n-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide cas number79770-24-4 ypubchem cid3738chemspider3607unii16fl47b687keggd01714 ychemblchembl1200555 ncomptox dashboard (epa)dtxsid0023165 chemical and physical dataformulac37h48i6n6o18molar mass1626.242 g·mol−13d model (jsmol)interactive image smiles cn(c1c(c(c(c(c1i)c(=o)nc(co)c(co)o)i)c(=o)nc(co)c(co)o)i)c(=o)cc(=o)n(c)c2c(c(c(c(c2i)c(=o)nc(co)c(co)o)i)c(=o)nc(co)c(co)o)i inchi inchi=1s/c37h48i6n6o18/c1-48(32-28(40)22(34(64)44-12(4-50)16(58)8-54)26(38)23(29(32)41)35(65)45-13(5-51)17(59)9-55)20(62)3-21(63)49(2)33-30(42)24(36(66)46-14(6-52)18(60)10-56)27(39)25(31(33)43)37(67)47-15(7-53)19(61)11-57/h12-19,50-61h,3-11h2,1-2h3,(h,44,64)(h,45,65)(h,46,66)(h,47,67)key:xuhxfsyubxnthu-uhfffaoysa-n ny (what is this?) (verify) as of 2021, it is unknown whether it is still marketed anywhere in the world. medical uses it is particularly used to image spaces surrounding the central nervous system, such as the ventricles, after injection into the cerebrospinal fluid; and also for angiography (imaging of blood vessels), urography (imaging of the urinary tract) and hysterosalpingography (imaging of uterus and fallopian tubes). it can also be used to image joint spaces and in endoscopic retrograde cholangiopancreatography (ercp). contraindications hysterosalpingography is contraindicated during pregnancy and during acute inflammation in the pelvic region. adverse effects the most common side effects are nausea and vomiting. redness and a hot feeling of the skin is relatively common when the medication is injected into a vein. when injected into the cerebrospinal fluid, headache is among the most common adverse effects, and sometimes confusion or hallucinations can occur. allergy-like reactions such as fever, hypotension (low blood pressure) and shock have also been observed. interactions drug interactions are similar to other iodine-containing contrast agents. iodine-131, a radioactive isotope used for thyroid imaging (scintigraphy) and therapy of thyroid cancers, can be less effective when used within two to six weeks after application of iotrolan because of residual iodine in the body. iotrolan can slow down the excretion of the diabetes drug metformin, potentially resulting in lactic acidosis. chemistry and mechanism of action further information: iodinated contrast chemically, the substance is a dimer of a triiodinated isophthalic acid derivative. the iodine atoms readily absorb x-rays, improving the contrast in x-ray images of the body. it is non-ionic but water soluble.