mitratapide mitratapide mitratapide is a veterinary drug for the treatment of overweight and obese dogs sold under the brand name yarvitan. its mechanism of action involves inhibition of microsomal triglyceride transfer protein (mtp) which is responsible for the absorption of dietary lipids. clinical study also suggests that mitratapide may help to reverse insulin resistance in dogs. mitratapideclinical datatrade namesyarvitanother namesmitratapid; r103757routes ofadministrationby mouth (0.5% solution)atcvet codeqa08ab90 (who) pharmacokinetic databioavailability55–69%protein binding>99.9%metabolismextensive liver (sulfoxidation); first pass effectelimination half-life6.3 hours (mitratapide), up to 44.7 hours (metabolites)excretionfeces (80–90%)identifiers iupac name 2--4--1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one cas number179602-65-4pubchem cid213047chemspider184740uniifvw7t75xp4keggd05060chemical and physical dataformulac36h41cln8o4smolar mass717.29 g·mol−13d model (jsmol)interactive image smiles cc(c)n1c(=o)n(c=n1)c2=cc=c(c=c2)n3ccn(cc3)c4=cc=c(c=c4)oc5co(o5)(csc6=nn=cn6c)c7=cc=c(c=c7)cl inchi inchi=1s/c36h41cln8o4s/c1-4-26(2)45-35(46)44(25-39-45)31-11-9-29(10-12-31)42-17-19-43(20-18-42)30-13-15-32(16-14-30)47-21-33-22-48-36(49-33,27-5-7-28(37)8-6-27)23-50-34-40-38-24-41(34)3/h5-16,24-26,33h,4,17-23h2,1-3h3/t26-,33-,36-/m1/s1key:hqsrvyucbocbly-xoofnslwsa-n the drug was developed by janssen pharmaceutica and is chemically related to the antifungal drugs such as itraconazole which were also developed by janssen. mitratapide (under the brand name yarvitan) was authorized for use in the eu by the european medicines agency for helping weight loss in dogs, but it has since been withdrawn from the market in the eu.