tropisetron tropisetron tropisetron is a serotonin 5-ht3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. not to be confused with tropanserin. tropisetronclinical datatrade namesnavobanother namesics 205-930ahfs/drugs.cominternational drug namespregnancycategory au: b3 routes ofadministrationoral, ivatc codea04aa03 (who) legal statuslegal status au: s4 (prescription only) uk: pom (prescription only) us: not available or approved pharmacokinetic databioavailability~60–80%protein binding71%metabolismhepatic (cyp3a4, cyp1a2, cyp2d6)elimination half-life6–8 hoursexcretionrenal, fecalidentifiers iupac name (1r,5s)-8-methyl-8-azabicyclooctan-3-yl 1methyl-indole-3-carboxylate cas number89565-68-4 npubchem cid72165iuphar/bps260chemspider16736476 yunii6i819nik1wkeggd02130 ychebichebi:32269 nchemblchembl496980 ncomptox dashboard (epa)dtxsid2044137 chemical and physical dataformulac17h20n2o2molar mass284.359 g·mol−13d model (jsmol)interactive image smiles cn41cc4c(c1)oc(=o)c3cc2ccccc23 inchi inchi=1s/c17h20n2o2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18h,6-9h2,1h3/t11-,12+,13+ ykey:znrgqmmcghdtei-itguqsilsa-n y ny (what is this?) (verify) it was patented in 1982 and approved for medical use in 1992. it is on the world health organization's list of essential medicines. it is marketed by novartis in europe, australia, new zealand, japan, south korea and the philippines as navoban, but is not available in the u.s. it is also available from novell pharmaceutical laboratories and marketed in several asian countries as setrovel. pharmacology tropisetron acts as both a selective 5-ht3 receptor antagonist and α7-nicotinic receptor agonist. adverse effects tropisetron is a well-tolerated drug with few side effects. headache, constipation, and dizziness are the most commonly reported side effects associated with its use. hypotension, transient liver enzyme elevation, immune hypersensitivity syndromes and extrapyramidal side effects have also been associated with its use on at least one occasion. there have been no significant drug interactions reported with this drug's use. it is broken down by the hepatic cytochrome p450 system and it has little effect on the metabolism of other drugs broken down by this system. other uses as a biological stain and as trypanocide