2,8-dihydroxyhexahydrochrysene 2,8-dihydroxyhexahydrochrysene 2,8-dihydroxyhexahydrochrysene (2,8-dhhhc) is a synthetic, nonsteroidal weak estrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogen diethylstilbestrol. it is said to be intermediate in structure between estradiol and hexestrol, but conversely to both of them, is drastically less potent in comparison. 2,8-dihydroxyhexahydrochryseneclinical dataatc codenonechemical and physical dataformulac18h18o2molar mass266.340 g·mol−1