benedikt syndrome benedikt syndrome benedikt syndrome, also called benedikt's syndrome or paramedian midbrain syndrome, is a rare type of posterior circulation stroke of the brain, with a range of neurological symptoms affecting the midbrain, cerebellum and other related structures. benedikt syndromeother namesparamedian midbrain syndromespecialtyneurology signs and symptoms it is characterized by the presence of an oculomotor nerve (cn iii) palsy and cerebellar ataxia including tremor and involuntary choreoathetotic movements. neuroanatomical structures affected include the oculomotor nucleus, red nucleus, corticospinal tracts and superior cerebellar peduncle decussation. it has a similar cause, morphology, signs and symptoms to weber's syndrome; the main difference between the two being that weber's is more associated with hemiplegia (i.e. paralysis), and benedikt's with hemiataxia (i.e. disturbed coordination of movements). it is also similar to claude's syndrome, but is distinguishable in that benedikt's has more predominant tremor and choreoathetotic movements while claude's is more marked by the ataxia. causes benedikt syndrome is caused by a lesion (infarction, hemorrhage, tumor, or tuberculosis) in the tegmentum of the midbrain and cerebellum. specifically, the median zone is impaired. it can result from occlusion of the posterior cerebral artery or paramedian penetrating branches of the basilar artery. diagnosis oculomotor nerve palsy: eyeball gazing downward and outward position, diplopia, miosis, mydriasis, and loss of accommodation reflex. contralateral loss of proprioception and vibration sensations. cerebellar ataxia: involuntary movements. treatment deep brain stimulation may provide relief from some symptoms of benedikt syndrome, particularly the tremors associated with the disorder.