toxidrome toxidrome a toxidrome (a portmanteau of toxic and syndrome) is a syndrome caused by a dangerous level of toxins in the body. the term was coined in 1970 by mofenson and greensher. it is often the consequence of a drug overdose. common symptoms include dizziness, disorientation, nausea, vomiting, and oscillopsia. a toxidrome may indicate a medical emergency requiring treatment at a poison control center. aside from poisoning, a systemic infection may also lead to a toxidrome. "classic" toxidromes are presented below, but they are often variable or obscured by the co-ingestion of multiple drugs. toxidrome flowchart diagnosis toxidrome symptomsbphrrrtemppupil sizebowel soundsdiaphoresis anticholinergicupupupupupdowndown cholinergic~~~~downupup hallucinogenicupupup~upup~ sympathomimeticupupupupupupup sedative-hypnoticdowndowndowndown~downdown anticholinergic