corticotropin-like intermediate peptide corticotropin-like intermediate peptide corticotropin-like intermediate peptide (clip), also known as adrenocorticotropic hormone fragment 18-39 (acth(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence arg-pro-val-lys-val-tyr-pro-asn-gly-ala-glu-asp-glu-ser-ala-glu-ala-phe-pro-leu-glu-phe. clip is generated as a proteolyic cleavage product of adrenocorticotropic hormone (acth), which in turn is a cleavage product of proopiomelanocortin (pomc). its physiological role has been investigated in various tissues, specifically in the central nervous system. pro-opiomelanocortinidentifierssymbolpomcncbi gene5443hgnc9201omim176830refseqnm_000939uniprotp01189other datalocuschr. 2 p23search forstructuresswiss-modeldomainsinterpro corticotropin-like intermediate peptide names iupac name l-arginyl-l-prolyl-l-valyl-l-lysyl-l-valyl-l-tyrosyl-l-prolyl-l-asparaginyl-l-glycyl-l-alanyl-l-α-glutamyl-l-α-aspartyl-l-α-glutamyl-l-seryl-l-alanyl-l-α-glutamyl-l-alanyl-l-phenylalanyl-l-prolyl-l-leucyl-l-α-glutamyl-l-phenylalanine identifiers cas number 53917-42-3 3d model (jsmol) interactive image chemspider 14195066 pubchem cid 102307347 inchi inchi=1s/c112h165n27o36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141h,16-21,26-30,35-55,113-114h2,1-9h3,(h2,115,142)(h,119,157)(h,120,143)(h,121,158)(h,122,165)(h,123,155)(h,124,154)(h,125,163)(h,126,164)(h,127,169)(h,128,159)(h,129,166)(h,130,167)(h,131,156)(h,132,170)(h,133,160)(h,134,161)(h,135,162)(h,136,168)(h,144,145)(h,146,147)(h,148,149)(h,150,151)(h,152,153)(h,174,175)(h4,116,117,118)/t59-,60-,61-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,89-,90-/m0/s1key: zydmzkpapszilb-wkndhwivsa-nkey: zydmzkpapszilb-uhfffaoyan smiles c(c(=n(ccc(=o)o)c(=n(cc(=o)o)c(=n(ccc(=o)o)c(=n(co)c(=n(c)c(=n(ccc(=o)o)c(=n(c)c(=n(cc1=cc=cc=c1)c(=o)n2ccc2c(=n(cc(c)c)c(=n(ccc(=o)o)c(=n(cc3=cc=cc=c3)c(=o)o)o)o)o)o)o)o)o)o)o)o)o)n=c(cn=c((cc(=n)o)n=c(4cccn4c(=o)(cc5=cc=c(c=c5)o)n=c((c(c)c)n=c((ccccn)n=c((c(c)c)n=c(6cccn6c(=o)(cccnc(=n)n)n)o)o)o)o)o)o)o properties chemical formula c112h165n27o36 molar mass 2465.705 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references it has been suggested to function as an insulin secretagogue in the pancreas.