sarolaner sarolaner sarolaner, sold under the brand name simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. it is also used off-label to control sarcoptic mange and demodectic mange. sarolanerclinical datatrade namessimparicaother namespf-6450567atcvet codeqp53be03 (who) legal statuslegal status us: ℞-only identifiers iupac name 1-spiro-1'-yl]-2-methylsulfonylethanone cas number1398609-39-6pubchem cid73169092chemspider31458198uniidm113ftw7fkeggd10668chemblchembl3137302echa infocard100.234.000 chemical and physical dataformulac23h18cl2f4n2o5smolar mass581.36 g·mol−13d model (jsmol)interactive image smiles cs(=o)(=o)cc(=o)n1cc2(c1)occ1cc(c3=no(c4cc(cl)c(f)c(cl)c4)(c(f)(f)f)c3)ccc12 inchi inchi=1s/c23h18cl2f4n2o5s/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6h,7-11h2,1h3/t22-/m0/s1key:flefkkuzmdeuip-qfipxvfzsa-n sarolaner is also a component of the combination drug simparica trio, which contains sarolaner, moxidectin, and pyrantel. it is used for prevention of heartworm disease caused by dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, gulf coast tick, american dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections. sarolaner is also an ingredient in feline combination antiparasitic revolution plus (or stronghold plus), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks.