triprolidine triprolidine triprolidine is an over-the-counter antihistamine with anticholinergic properties. it is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. as with many antihistamines, the most common side effect is drowsiness. triprolidineclinical datatrade namesactidil, myidil, actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin)ahfs/drugs.commonographpregnancycategory c (us) routes ofadministrationoralatc coder06ax07 (who) legal statuslegal status us: otc pharmacokinetic databioavailability4% oralprotein binding90%metabolismhepatic (cyp2d6)elimination half-life4–6 hoursexcretionrenalidentifiers iupac name 2-pyridine cas number486-12-4 ypubchem cid5282443iuphar/bps1228drugbankdb00427 ychemspider4445597 yunii2l8t9s52qmkeggd01782 nchebichebi:84116 nchemblchembl855 ycomptox dashboard (epa)dtxsid3023718 echa infocard100.006.934 chemical and physical dataformulac19h22n2molar mass278.399 g·mol−13d model (jsmol)interactive imagemelting point60 °c (140 °f)solubility in water500 mg/ml (20 °c) smiles n3c(\c(=c\cn1cccc1)c2ccc(cc2)c)cccc3 inchi inchi=1s/c19h22n2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12h,4-5,13-15h2,1h3/b18-11+ ykey:cbequlmoccwaqt-wojgmqoqsa-n y ny (what is this?) (verify) it was patented in 1948 and came into medical use in 1953.