thenylfentanyl thenylfentanyl thenylfentanyl is an analogue of fentanyl where the phenethylamine side-chain has been replaced by a thiophenylmethyl group. it was temporarily scheduled by the drug enforcement administration in 1985, due to fears it would be used as a designer drug. but in 2010 the dea acknowledged it was essentially inactive. subsequently, the substance was since deregulated. not to be confused with thiafentanil or thiofentanyl. thenylfentanylchemical structure of thenylfentanyllegal statuslegal status us: unscheduled identifiers iupac name n-phenyl-n-propanamide cas number122861-39-6pubchem cid21595404chemspider10551387unii7o0847nue9chemblchembl2365725chemical and physical dataformulac19h24n2osmolar mass328.47 g·mol−13d model (jsmol)interactive image smiles ccc(=o)n(c1ccn(cc1)cc2=cc=cs2)c3=cc=cc=c3 inchi inchi=inchi=1s/c19h24n2os/c1-2-19(22)21(16-7-4-3-5-8-16)17-10-12-20(13-11-17)15-18-9-6-14-23-18/h3-9,14,17h,2,10-13,15h2,1h3key:jsoswryhpgiwgt-uhfffaoysa-n legal status the legality of fentanyl analogues vary by country. in the united states, thenylfentanyl is unscheduled. uses in much the same way that benzylfentanyl can be used to synthesize fentanyl, thenylfentanyl could ostensibly be used for the same purpose. in such a procedure, thenylfentanyl would first be de-thiophenylmethylated to norfentanyl. this would be followed by amination to fentanyl using phenethyl bromide. chemistry thenylfentanyl is a n-arylalkylamide derivative of norfentanyl. the substance is also a structural isomer of acetylthiofentanyl, wherein a methyl group on the thiophene sidechain has been relocated to the carboxamide group nearest the aniline. it is due to this reduced sidechain length that thenylfentanyl has dramatically diminished mor activity compared to other fentanyl analogues. many of fentanyl’s analogues were discovered by paul janssen.