profenamine profenamine profenamine (inn; also known as ethopropazine (ban); trade names parsidol, parsidan, parkin) is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. it is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia. profenamineclinical datatrade namesparsidol, parsidan, parkinahfs/drugs.cominternational drug namesatc coden04aa05 (who) pharmacokinetic dataprotein binding93%elimination half-life1 to 2 hoursidentifiers iupac name n,n-diethyl-1-(10h-phenothiazin-10-yl)propan-2-amine cas number522-00-9 npubchem cid3290iuphar/bps7181drugbankdb00392 ychemspider3174 yunii7wi4p02yn1chebichebi:313639 ychemblchembl1206 ycomptox dashboard (epa)dtxsid2023018 echa infocard100.007.566 chemical and physical dataformulac19h24n2smolar mass312.48 g·mol−13d model (jsmol)interactive image smiles s2c1ccccc1n(c3c2cccc3)cc(n(cc)cc)c inchi inchi=1s/c19h24n2s/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15h,4-5,14h2,1-3h3 ykey:cdozdbsbbxsxlb-uhfffaoysa-n y ny (what is this?) (verify) synthesis for promoting bone growth: synthesis: patents: the alkylation between phenothiazine (1) and 1-diethylamino-2-chloropropane (2) in the presence of sodium amide gives ethopropazine (3). the aziridinium salt helps to rationalize why a rearrangement product is observed (ala methadone). this was also observewd for aceprometazine.