isoetarine isoetarine isoetharine is a selective short-acting β2 adrenoreceptor agonist. it can be called the "granddaughter of adrenalin" in the line of β2 agonists that gave quick relief for bronchospasm and asthma. epinephrine (adrenalin) was the first of these, and next came isoprenaline (isoproterenol). isoetharine was the third drug in this line, thus the third generation or granddaughter of the original. isoetharineclinical datapronunciation/aɪsoʊˈɛθəriːn/ eye-soh-eth-ə-reen trade namesbronkosol and bronkometer (usan name is isoetharine)ahfs/drugs.cominternational drug namesmedlineplusa682862atc coder03ac07 (who) legal statuslegal status au: s4 (prescription only) identifiers iupac name (rs)-4-benzene-1,2-diol cas number79490-84-9 ypubchem cid3762iuphar/bps7205drugbankdb00221 ychemspider3630 yuniiyv0sn3276qkeggd04625 ychemblchembl1201213 ncomptox dashboard (epa)dtxsid9048560 echa infocard100.007.703 chemical and physical dataformulac13h21no3molar mass239.315 g·mol−13d model (jsmol)interactive imagechiralityracemic mixture smiles oc1ccc(cc1o)c(o)c(nc(c)c)cc inchi inchi=1s/c13h21no3/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9/h5-8,10,13-17h,4h2,1-3h3 ykey:huywawarquiqle-uhfffaoysa-n y ny (what is this?) (verify) in the western united states, it was the drug of choice in the late 1970s and early 1980s for nebulization ("breathing treatment") to relieve airway spasm. it generally gave sharp relief of shortness of breath, starting within two to five minutes after the patient began breathing the nebulized mist. this rapid onset is not as clearly present in later drugs. all of the early β2 agonist catecholamines used for bronchospasm had strong side effects, with increase in heart rate as the most common and most problematic. this came because its "β2 effect" was not quite as selective as might be hoped. β1 receptors appeared to also be stimulated in some patients, causing cardiac and other cns side effects. with isoetharine this effect tended to be transient and usually went away within a matter of minutes after the end of the treatment. increase in blood pressure also occurred in a small but significant percentage of cases, but also was almost invariably transient. by the late 1980s, isoetharine was largely replaced by orciprenaline (metaproterenol), which seemed to have slightly less cardiac side effect and lasted a couple of hours longer. orciprenaline in turn was replaced by salbutamol (albuterol). some practitioners still believe that these later aerosolized bronchodilators never gave quite as quick of relief from asthmatic shortness of breath as did isoetharine. thus they see a continued specialty role in treatment of severe shortness of breath that does not improve in the first five minutes of salbutamol treatment.