hla-a32 hla-a32 hla-a32 (a32) is a human leukocyte antigen serotype within hla-a serotype group. the serotype is determined by the antibody recognition of α32 subset of hla-a α-chains. for a32, the alpha "a" chain are encoded by the hla-a*32 allele group and the β-chain are encoded by b2m locus. this group currently is dominated by a*3201. a32 and a*32 are almost synonymous in meaning. a32 is a split antigen of the broad antigen serotype a19. a32 is a sister serotype of a29, a30, a31, a33, and a74. further information: history and naming of human leukocyte antigens hla-a32(mhc class i, a cell surface antigen)hla-a32aboutproteintransmembrane receptor/ligandstructureαβ heterodimersubunitshla-a*3201, β2-microglobulinolder names"a19"subtypessubtype allele available structuresa19 *3201 *32 *32 *32 alleles link-out to imgt/hla database at ebi serotype a32 recognition of some hla a*32 gene products a*32 a32 sample allele % size (n) *3201943441 a32 serotyping efficiency for the predominant allele is good. there are 16 known alleles that result in 15 isoforms of hla-a32. one isoform may be poorly expressed.. distribution hla a*3201 frequenciesstudy populationfreq. (in %)oman11.4pakistan brahui9.2italy sardinia8.7bulgaria8.2burkina faso fulani8.2pakistan karachi parsi7.8pakistan kalash7.5france south east7.2pakistan baloch7.1greece north7.0georgia tbilisi kurds6.7iran baloch6.7spain north cantabrian6.0italy bergamo5.9india north hindus5.8croatia5.7france corsica5.5scotland orkney5.5sudanese5.5spain eastern andalusia5.4algeria15.1azores santa maria and sa…5.1pakistan pathan5.1pakistan sindhi5.1romanian5.0macedonia4.9cape verde northwestern i…4.8georgia tbilisi georgian…4.8serbia4.6ireland south4.4england lancaster4.4azores terceira island4.3usa caucasian pop24.3bulgaria gipsy4.2cape verde southeastern i…4.0israel arab druse4.0portugal centre4.0burkina faso mossi3.8guinea bissau3.8spain north cabuernigo3.8belgium3.7russia chuvash3.7sweden stockholm3.5wales3.5england sheffield3.5england leeds3.4australia new south wales3.4morocco berber nador meta…3.4ireland northern3.2jordan amman3.1india khandesh pawra3.0india new delhi3.0india west coast parsis3.0usa hispanic3.0turkey2.8sweden uppsala county2.7india north delhi2.7morocco2.7pakistan burusho2.7kenya luo2.6south african natal zulu2.5china north han2.4czech republic2.4london ashkenazi jews2.4mexico mestizos2.4saudi arabia guraiat and …2.4china beijing2.2finland2.2uganda kampala2.2russia tuva pop 22.1usa north american native…2.1brazil2.0cameroon beti2.0peru arequipa2.0russia arkhangelsk pomors2.0italy north pop 11.9russia northwest1.8german essen1.8spain pas valley1.6usa african america1.6tunisia1.5georgia svaneti svans1.3new caledonia1.2south africa tswana1.2 allele frequencies presented, only a32 is most common around the persian gulf and the mediterranean basin. it has a consistent presence in europe. the a32 frequencies in the more isolated (genetically) peoples of europe suggests that the a32 rise in the mediterranean may only be partially attributable to recent migrations from the middle eastern region. there is a node in southern europe around the ionian sea in which specific, european, a32-haplotypes are elevated. haplotypes hla a32 haplotype frequencies freq ref.population(%) a32-b7(a*3201:b*0702) albanian2.2 cuban1.9 natal zulu (s. africa)1.0 cretan0.7 cretan0.2 a32-b8(a*3201:b*0801) n. portugal2.2 oman1.8 a32-b14(a*3201:b*14) !kung1.9 tunis1.8 natal zulu (s. africa)1.0 portugal1.1 irish0.7 italian0.6 a32-b27(a*3201:b27) gypsy(spanish)6.0 e black sea (turkey)2.3 german0.3 a32-b35(a*3201:c*0401:b*3501) greek3.5 ua emirates2.8 sardinian2.6 brahui (pakistan)2.5 tunisia1.8 armenian1.7 italian1.5 oman1.3 portugal1.1 german0.3 a32-b61(40)(a*3201:b*40) tunis1.2 greek1.2 french0.6 german0.4 a32-b44(a*3201:b*4402) austrian2.4 belgium2.0 albanian1.8 s. portugal1.0 irish0.7 german0.6 dutch0.6 senegal0.5 italian0.4 a32-b51(a*3201:c*1201:b*5101) bulgarian1.8 german0.3 (a*3201:c*1502:b*5101) oman5.0 baloch (pakistan)3.2 kalash2.9 ua emirates1.9 baloch (iran)1.1 (a*3201:c*1401:b*5101) parsis (karachi)4.9 kalash2.9 a common a32 haplotype a*3201-b*5101 can be found in oman, united arab emirates, se iran, bulgaria, and portugal. a second, a*3201-b*3501 can be in the omani, uae, and portugal.