ethacizine ethacizine ethacizine (ethacyzine) is a class ic antiarrhythmic agent, related to moracizine. it is used in russia and some other cis countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease. it is also indicated as a treatment of refractory tachycardia associated with wolff–parkinson–white syndrome. ethacizineclinical datatrade namesethacizinahfs/drugs.cominternational drug namesatc codec01bc09 (who) legal statuslegal status prescription only (ru) pharmacokinetic databioavailability~40% (oral)protein binding90%metabolismextensive hepaticelimination half-life2.5 hoursidentifiers iupac name ethyl n-phenothiazin-2-yl]carbamate cas number33414-33-4 ypubchem cid107841chemspider96982 yuniife5spv1z6gkeggd10503 ychemblchembl1997663 ncomptox dashboard (epa)dtxsid50187057 chemical and physical dataformulac22h27n3o3smolar mass413.54 g·mol−13d model (jsmol)interactive image smiles ccn(cc)ccc(=o)n1c2=cc=cc=c2sc3=c1c=c(c=c3)nc(=o)occ inchi inchi=1s/c22h27n3o3s/c1-4-24(5-2)14-13-21(26)25-17-9-7-8-10-19(17)29-20-12-11-16(15-18(20)25)23-22(27)28-6-3/h7-12,15h,4-6,13-14h2,1-3h3,(h,23,27) ykey:pqxgnjkjmfuppm-uhfffaoysa-n y it is manufactured under the brand name ethacizin (этацизин) by latvian pharmaceutical company olainfarm. synthesis for the treatment of heart infarction: synthesis: patent: the amide formation between phenothiazine-2-ethylcarbamate (1) and 3-chloropropionyl chloride (2) gives ethyl n-carbamate (3). displacement of the remaining ω-halogen by diethylamine (4) then completes the synthesis of ethacizine (5).