piquindone piquindone piquindone (ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. it acts as a selective d2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial. unlike most other d2 receptor ligands, piquindone displays na+-dependent binding, a property it shares with tropapride, zetidoline, and metoclopramide. piquindoneclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status in general: uncontrolled identifiers iupac name (4as,8as)-3-ethyl-2,6-dimethyl-1,4a,5,6,7,8,8a,9-octahydro-4h-pyrroloisoquinolin-4-one cas number78541-97-6 83784-19-4 (hydrochloride)pubchem cid121903chemspider108751uniio1c9wxy65cchemblchembl1192678chemical and physical dataformulac15h22n2omolar mass246.354 g·mol−13d model (jsmol)interactive image smiles o=c2c1c(c(c1cc)c)c32cn(cc3)c in clinical trials piquindone was found to possess moderate efficacy in treating positive symptoms of schizophrenia, and notably, was also modestly effective for negative symptoms, though this was just under statistical significance. additionally, relative to haloperidol, it was found to possesses significantly fewer extrapyramidal symptoms and had a much lower propensity for inducing tardive dyskinesia, indicating its atypical nature. in addition to psychosis, piquindone has also been found to be effective in the treatment of tourette's syndrome in numerous clinical studies.