lupus pernio lupus pernio lupus pernio is a chronic raised indurated (hardened) lesion of the skin, often purplish in color. it is seen on the nose, ears, cheeks, lips, and forehead. it is pathognomonic of sarcoidosis.: 701 the name "lupus pernio" is a misnomer, as microscopically this disease shows granulomatous infiltration and does not have features of either lupus nor pernio. lupus perniocutaneous lesions of sarcoidosis (lupus pernio). red-to-purple indurated plaques and nodules affecting the nose and cheeks.specialtydermatology lupus pernio is associated with poor outcomes and lower rates of resolution. lupus pernio and erythema nodosum are cutaneous manifestation of sarcoidosis, may suggest this disease as a cause of an associated dilated cardiomyopathy, especially with heart block, intraventricular conduction delay, or ventricular tachycardia.