tebipenem tebipenem tebipenem (brand name orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. it was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form. it has performed well in clinical trials for ear infection and looks likely to be further developed in future. it is only marketed in japan. tebipenem is the first carbapenem whose prodrug form, the pivalyl ester, is orally available. tebipenemtebipenem pivoxilclinical datatrade namesorapenemroutes ofadministrationoralatc codej01dh06 (who) legal statuslegal status prescription-only in japan; investigational elsewhere identifiers iupac name (4r,5s,6s)-(pivaloyloxy)methyl 3-((1-(4,5-dihydrothiazol-2-yl)azetidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclohept-2-ene-2-carboxylate cas number161715-24-8 nunii95ak1a52i8keggd09598pdb ligand1te (pdbe, rcsb pdb)comptox dashboard (epa)dtxsid00167228 chemical and physical dataformulac22h31n3o6s2molar mass497.63 g·mol−13d model (jsmol)interactive image smiles 12n(c(c(ococ(c(c)(c)c)=o)=o)=c(sc3cn(c4=nccs4)c3)2c)c(1((o)c))=o