psb-sb-487 psb-sb-487 psb-sb-487 is a coumarin derivative which is an antagonist at the former orphan receptor gpr55. unlike older gpr55 antagonists such as o-1918, psb-sb-487 has good selectivity over the related receptor gpr18, with an ic50 of 113nm at gpr55 vs 12500nm at gpr18. however it has poorer selectivity over other related receptors, acting as a weak antagonist at cb1 with a ki of 1170nm, and a partial agonist at cb2 with a ki of 292nm. psb-sb-487identifiers iupac name 7-(1,1-dimethyloctyl)-5-hydroxy-3-(2-hydroxybenzyl)-2h-chromen-2-one pubchem cid70678101chemspider28667155chemical and physical dataformulac26h32o4molar mass408.53 g·mol−13d model (jsmol)interactive image smiles oc1=c(cc2=cc3=c(c=c(c(c)(c)ccccccc)c=c3o)oc2=o)c=cc=c1 inchi inchi=1s/c26h32o4/c1-4-5-6-7-10-13-26(2,3)20-16-23(28)21-15-19(25(29)30-24(21)17-20)14-18-11-8-9-12-22(18)27/h8-9,11-12,15-17,27-28h,4-7,10,13-14h2,1-3h3key:ynwomouvwnkico-uhfffaoysa-n