late congenital syphilitic oculopathy late congenital syphilitic oculopathy late congenital syphilitic oculopathy is a disease of the eye, a manifestation of late congenital syphilis. it can appear as: interstitial keratitis – this commonly appears between ages 6 and 12. symptoms include lacrimation and photophobia. pathological vascularization of the cornea cause it to turn pink or salmon colored. 90% of cases affect both eyes. episcleritis or scleritis – nodules appear in or overlying the sclera (white of eye) iritis or iris papules – vascular infiltration of the iris causes rosy color change and yellow/red nodules. chorioretinitis, papillitis, retinal vasculitis – retinal changes can resemble retinitis pigmentosa. exudative retinal detachment late congenital syphilitic oculopathyspecialtyophthalmology congenital syphilis is categorized by the age of the child. early congenital syphilis occurs in children under 2 years old, and late congenital syphilis in children at or greater than 2 years old. manifestations of late congenital syphilis are similar to those of secondary syphilis and tertiary syphilis in adults.