loop diuretic loop diuretic loop diuretics are diuretics that act on the na-k-cl cotransporter along the thick ascending limb of the loop of henle in nephrons of the kidneys. they are primarily used in medicine to treat hypertension and edema often due to congestive heart failure or chronic kidney disease. while thiazide diuretics are more effective in patients with normal kidney function, loop diuretics are more effective in patients with impaired kidney function. loop diureticdrug classstructure of the loop diuretics furosemide, azosemide, bumetanide, piretanide, torasemide, ethacrynic acid and etozolinclass identifierssynonymshigh-ceiling diureticusecongestive heart failure, nephrotic syndrome, cirrhosis, hypertension, edemaatc codec03cbiological targetna-k-cl cotransporter