2β-propanoyl-3β-(2-naphthyl)-tropane 2β-propanoyl-3β-(2-naphthyl)-tropane 2β-propanoyl-3β-(2-naphthyl)-tropane or wf-23 (wake forest-23, named after the university where it was first created) is a cocaine analogue. it is several hundred times more potent than cocaine at being a serotonin-norepinephrine-dopamine reuptake inhibitor. 2β-propanoyl-3β-(2-naphthyl)-tropanepharmacokinetic databioavailabilityhighmetabolismslowidentifiers iupac name 1-octan-4-yl]propan-1-one pubchem cid10447943chemspider8623360chemical and physical dataformulac21h25nomolar mass307.437 g·mol−13d model (jsmol)interactive image smiles ccc(=o)12cc(c1c3ccc4ccccc4c3)n2c inchi inchi=1s/c21h25no/c1-3-20(23)21-18(13-17-10-11-19(21)22(17)2)16-9-8-14-6-4-5-7-15(14)12-16/h4-9,12,17-19,21h,3,10-11,13h2,1-2h3/t17-,18+,19+,21+/m0/s1key:wjvleidmfwniaa-qeuvdipisa-n as can be seen on pubmed, these acyl substituted phenyltropanes are highly potent mat inhibitors and also have a very long half-life, spanning perhaps at least a few days; as the half-life of the dopamine transporter in rats was found to be 2-3 days under normal conditions (with agonists, antagonists, and transporter inhibitors altering the half-life), it may be that wf-23 largely or mostly binds to its transporters until they are degraded.