type i cytokine receptor type i cytokine receptor type i cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. these receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (wsxws) in the extracellular portion adjacent to the cell membrane. members of the type i cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction. type i cytokine receptor, cytokine-binding domainidentifierssymboltypei_recpt_cbdpfampf09240pfam clancl0159interproipr015321scop21n26 / scope / supfammembranome2available protein structures:pfam structures / ecod pdbrcsb pdb; pdbe; pdbjpdbsumstructure summary the common cytokine-binding domain is related to the fibronectin type iii domain. signal transduction chains the signal transducing chains are often shared between different receptors within this receptor family. the il-2 receptor common gamma chain (also known as cd132) is shared between: il-2 receptor il-4 receptor il-7 receptor il-9 receptor il-13 receptor il-15 receptor il-21 receptor the common beta chain (cd131 or cdw131) is shared between the following type i cytokine receptors: gm-csf receptor il-3 receptor il-5 receptor. the gp130 receptor (glycoprotein 130) (also known as gp130, il6st, il6-beta or cd130) is shared between: il-6 receptor il-11 receptor il-12 receptor il-27 receptor leukemia inhibitory factor receptor oncostatin m receptor examples type i cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors interleukin receptors interleukin-1 receptor interleukin-2 receptor interleukin-3 receptor interleukin-4 receptor interleukin-5 receptor interleukin-6 receptor interleukin-7 receptor interleukin-9 receptor interleukin-11 receptor interleukin-12 receptor interleukin-13 receptor interleukin-15 receptor interleukin-18 receptor interleukin-21 receptor interleukin-23 receptor interleukin-27 receptor colony stimulating factor receptors erythropoietin receptor gm-csf receptor g-csf receptor thrombopoietin receptor hormone receptor/neuropeptide receptor growth hormone receptor prolactin receptor leptin receptor other oncostatin m receptor leukemia inhibitory factor receptor