lipopolysaccharide binding protein lipopolysaccharide binding protein lipopolysaccharide binding protein (lbp) is a protein that in humans is encoded by the lbp gene. lbpavailable structurespdbortholog search: pdbe rcsb list of pdb id codes4m4didentifiersaliaseslbp, bpifd2, lipopolysaccharide binding proteinexternal idsomim: 151990 mgi: 1098776 homologene: 3055 genecards: lbp gene location (human)chr.chromosome 20 (human)band20q11.23start38,346,482 bpend38,377,013 bpgene location (mouse)chr.chromosome 2 (mouse)band2 h1|2 78.72 cmstart158,148,413 bpend158,174,772 bprna expression patternbgeehumanmouse (ortholog)top expressed inright lobe of livertibialis anterior musclegastrocnemius muscleappendixdeltoid musclesubcutaneous adipose tissueright lobe of thyroid glandpericardiumkidneysynovial membranetop expressed inankleankle jointleft lobe of liveruterusparotid glandwhite adipose tissuestria vasculariscarotid bodyright lung lobeoptic nervemore reference expression databiogpsmore reference expression datagene ontologymolecular function lipoteichoic acid binding protein binding lipid binding signaling receptor binding lipopolysaccharide binding lipopeptide binding cellular component membrane extracellular exosome extracellular region cell surface extracellular space biological process detection of molecule of bacterial origin lipid transport toll-like receptor 4 signaling pathway immune system process leukocyte chemotaxis involved in inflammatory response cellular defense response cellular response to lipoteichoic acid defense response to bacterium lipopolysaccharide transport positive regulation of interleukin-8 production positive regulation of interleukin-6 production positive regulation of neutrophil chemotaxis positive regulation of toll-like receptor 4 signaling pathway positive regulation of chemokine production negative regulation of tumor necrosis factor production lipopolysaccharide-mediated signaling pathway opsonization defense response to gram-negative bacterium positive regulation of tumor necrosis factor production response to lipopolysaccharide macrophage activation involved in immune response positive regulation of respiratory burst involved in inflammatory response acute-phase response innate immune response defense response to gram-positive bacterium cellular response to lipopolysaccharide positive regulation of macrophage activation toll-like receptor signaling pathway macromolecule localization positive regulation of cytolysis transport cytokine-mediated signaling pathway sources:amigo / quickgoorthologsspecieshumanmouseentrez392916803ensemblensg00000129988ensmusg00000016024uniprotp18428q61805refseq (mrna)nm_004139nm_008489refseq (protein)np_004130np_032515location (ucsc)chr 20: 38.35 – 38.38 mbchr 2: 158.15 – 158.17 mbpubmed searchwikidataview/edit humanview/edit mouse lbp is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or lps) to elicit immune responses by presenting the lps to important cell surface pattern recognition receptors called cd14 and tlr4. the protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. gram-negative bacteria contain a glycolipid, lipopolysaccharide (lps), on their outer cell wall. together with bactericidal permeability-increasing protein (bpi), the encoded protein binds lps and interacts with the cd14 receptor, probably playing a role in regulating lps-dependent monocyte responses. studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to lps but not for the clearance of lps from circulation. this protein is part of a family of structurally and functionally related proteins, including bpi, plasma cholesteryl ester transfer protein (cetp), and phospholipid transfer protein (pltp). finally, this gene is found on chromosome 20, immediately downstream of the bpi gene. clinical significance lps exposure induces lbp production. lbp is synthesized by the liver, adipose tissue, and intestinal cells. dietary glucose and saturated fats acutely increase plasma lbp. the proinflammatory activity of plasma lps is increased by lbp, which is higher in obesity. plasma lbp is used as a better biomarker of plasma lps than lps itself due to the short half-life of lps. interactions lipopolysaccharide-binding protein has been shown to interact with cd14, tlr2, tlr4 and the co-receptor md-2.