ichthyosis linearis circumflexa ichthyosis linearis circumflexa ichthyosis linearis circumflexa is a distinctive skin condition of generalized hyperkeratosis and polycyclic and serpiginous erythematous plaques with a characteristic, migratory, double-edged scale at the margins, and is the typical cutaneous manifestation of netherton's syndrome.: 496 : 563 ichthyosis linearis circumflexaspecialtydermatology