micrographia (handwriting) micrographia (handwriting) micrographia, an acquired disorder, features abnormally small, cramped handwriting. it is commonly associated with neurodegenerative disorders of the basal ganglia, such as in parkinson's disease, but it has also been ascribed to subcortical focal lesions. o'sullivan and schmitz describe it as an abnormally small handwriting that is difficult to read, as seen in the photo to the right. micrographia is also seen in patients with wilson's disease, obsessive compulsive disorder, metamorphopsia, or with isolated focal lesions of the midbrain or basal ganglia. example of writing by a patient with parkinson's disease that is possibly showing micrographia in addition to other abnormal characteristics. published by jean-martin charcot in 1879. parkinson's disease a common feature of parkinson's disease (pd) is difficulty in routine activities due to lack of motor control. patients have trouble maintaining the scale of movements and have reduced amplitude of movement (hypokinesia). in pd, the trouble in scaling and controlling the amplitude of movement affects complex, sequential movements, so that micrographia is a common symptom. another cause of micrographia is lack of physical dexterity. james parkinson may have been aware of micrographia in patients with shaking palsy (later renamed parkinson's disease), when he described "the hand failing to answer with exactness to the dictates of the will". occurrence in parkinson's micrographia is often seen patients with parkinson’s disease, although the precise prevalence is uncertain, with reported figures of between 9% and 75%. often appearing before other symptoms, it can help in diagnosis. pharmacological management micrographia may worsen when a pd patient is under-medicated and when the medication is wearing off.