jwh-146 jwh-146 jwh-146 (1-heptyl-5-phenyl-1h-pyrrol-3-yl)-1-naphthalenyl-methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the cb1 (ki = 21 ± 2nm) and cb2 (ki = 62 ± 5nm) receptors, with a moderate (~2.9x) selectivity for the cb1 receptor over the cb2 receptor. jwh-146 was first synthesized in 2006 by john w. huffman and colleagues to examine the nature of ligand binding to the cb1 receptor. jwh-146legal statuslegal status ca: schedule ii uk: class b identifiers iupac name (1-heptyl-5-phenyl-1h-pyrrol-3-yl)-1-naphthalenyl-methanone cas number914458-21-2 ypubchem cid44418308chemspider23277883 yunii5446svk6lhchemblchembl219970 nchemical and physical dataformulac28h29nomolar mass395.546 g·mol−13d model (jsmol)interactive image smiles o=c(c1=cc=cc2=c1c=cc=c2)c3=cn(ccccccc)c(c4=cc=cc=c4)=c3 inchi inchi=1s/c28h29no/c1-2-3-4-5-11-19-29-21-24(20-27(29)23-14-7-6-8-15-23)28(30)26-18-12-16-22-13-9-10-17-25(22)26/h6-10,12-18,20-21h,2-5,11,19h2,1h3 ykey:jdbfnfbwxvctsa-uhfffaoysa-n y legality in the united states jwh-146 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of jwh-146. in canada, jwh-146 and other naphthoylpyrrole-based cannabinoids are schedule ii controlled substances under the controlled drugs and substances act. in the united kingdom, jwh-146 and other naphthoylpyrrole-based cannabinoids are considered class b drugs under the misuse of drugs act 1971.