fluocinonide fluocinonide fluocinonide (sold under various brand names) is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. it relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort. fluocinonideclinical datatrade namesfluonex, lidex, othersahfs/drugs.commicromedex detailed consumer informationmedlineplusa601054routes ofadministrationtopicalatc codec05aa11 (who) d07ac08 (who)legal statuslegal status au: s4 (prescription only) uk: pom (prescription only) us: ℞-only pharmacokinetic datametabolismhepaticidentifiers iupac name 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate cas number356-12-7 ypubchem cid9642iuphar/bps7078drugbankdb01047 ychemspider9265 yunii2w4a77ypankeggd00325 ychemblchembl1501 ycomptox dashboard (epa)dtxsid8045307 echa infocard100.005.998 chemical and physical dataformulac26h32f2o7molar mass494.532 g·mol−13d model (jsmol)interactive image smiles o=c(occ(=o)45oc(o5c24(c(o)3(f)/1(/c=c\c(=o)\c=c\1(f)c23)c)c)(c)c)c inchi inchi=1s/c26h32f2o7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31h,9-12h2,1-5h3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 ykey:wjohzncjwywujd-iugzlztksa-n y (verify) a common potential adverse effect is skin atrophy (thinning of the skin). systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal axis (hpa) suppression, manifestations of cushing's syndrome, hyperglycemia, and glucosuria. in 2020, it was the 280th most commonly prescribed medication in the united states, with more than 1 million prescriptions. veterinary uses fluocinonide is used in veterinary medicine. it is a treatment for allergies in dogs. natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.