2-mdp 2-mdp 2-mdp (u-23807a) is a dissociative anaesthetic drug which has been found to be an nmda antagonist and produces similar effects to pcp in animals. the levo or (-) isomer is the active form of the drug. it also has stimulant effects, having only around one third the potency of amphetamine by weight, but with a long duration of action, lasting more than 24 hours from a single oral dose. 2-mdpidentifiers iupac name 3-amino-2-methyl-1,1-di(phenyl)propan-1-ol cas number14326-31-9 yhcl: 14185-05-8 ypubchem cid26538chemspider24719 yuniib6ftk35fgchcl: tjh732rkt9 ycomptox dashboard (epa)dtxsid90912320 chemical and physical dataformulac16h19nomolar mass241.334 g·mol−13d model (jsmol)interactive image smiles oc(c1ccccc1)(c2ccccc2)c(c)cn inchi inchi=1s/c16h19no/c1-13(12-17)16(18,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,13,18h,12,17h2,1h3 ykey:xgychipephyuih-uhfffaoysa-n y ny (what is this?) (verify) effects the therapeutic action is said to exhibit appetite suppressant and antidepressant like activity. synthesis 2-mdp synthesis: in a variation of the nitrile-aldol reaction (also demonstrated for venlafaxine), combination of benzophenone (1) and propionitrile (2), in the presence of sodamide base and ethyl ether solvent, leads to 3-hydroxy-2-methyl-3,3-diphenylpropanenitrile (3). the reduction of the intermediate nitrile group with lithium aluminium hydride completed the synthesis of u-23,807a (4).