anti-lkm antibody anti-lkm antibody an anti-lkm antibody (anti–liver-kidney microsomal antibody or lkm antibody) is any of several autoantibodies that are detected in the serum of patients with different types of acute or chronic liver disease. these antibodies are targeted against antigens of the cytochrome p450 system. classification there are three kinds of anti-lkm antibodies: microsomal antibodyantigendisease anti-lkm 1cytochrome p450 2d6autoimmune hepatitis type ii and chronic hepatitis c (10%) anti-lkm 2cytochrome p450 2c9drug-induced hepatitis (tienilic acid–induced) anti-lkm 3cytochrome p450 1a2chronic active hepatitis in association with autoimmune polyendocrine syndrome type 1; hepatitis d