thc hemisuccinate thc hemisuccinate thc hemisuccinate (δ9-thc-o-hemisuccinate, dronabinol hemisuccinate) is a synthetic derivative of tetrahydrocannabinol, developed in the 1990s. it is a water-soluble prodrug ester which is converted into thc inside the body, and was developed to overcome the poor bioavailability of thc when taken by non-inhaled routes of administration. thc hemisuccinateidentifiers iupac name 4-chromen-1-yl]oxy]-4-oxobutanoic acid cas number52855-15-9 ypubchem cid162707chemspider142849comptox dashboard (epa)dtxsid40200885 chemical and physical dataformulac25h34o5molar mass414.542 g·mol−13d model (jsmol)interactive image smiles cccccc1=cc2=c(3c=c(cc3c(o2)(c)c)c)c(=c1)oc(=o)ccc(=o)o inchi inchi=1s/c25h34o5/c1-5-6-7-8-17-14-20(29-23(28)12-11-22(26)27)24-18-13-16(2)9-10-19(18)25(3,4)30-21(24)15-17/h13-15,18-19h,5-12h2,1-4h3,(h,26,27)/t18-,19-/m1/s1key:yvooduuydjkfdy-rtburbonsa-n