cutaneous myxoma cutaneous myxoma a cutaneous myxoma, or superficial angiomyxoma, consists of a multilobulated myxoid mass containing stellate or spindled fibroblasts with pools of mucin forming cleft-like spaces. there is often a proliferation of blood vessels and an inflammatory infiltrate. staining is positive for vimentin, negative for cytokeratin and desmin, and variable for cd34, factor viiia, sma, msa and s-100. cutaneous myxoma clinically, it may present as solitary or multiple flesh-colored nodules on the face, trunk, or extremities. it may occur as part of the carney complex, and is sometimes the first sign. local recurrence is common.