n-terminal domain antiandrogen n-terminal domain antiandrogen n-terminal domain antiandrogens are a novel type of antiandrogen that bind to the n-terminal domain of the androgen receptor (ar) instead of the ligand-binding domain (where all currently-available antiandrogens bind) and disrupt interactions between the ar and its coregulatory binding partners, thereby blocking ar-mediated gene transcription. they are being investigated for the treatment of prostate cancer.