cefotetan cefotetan cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. it is often grouped together with second-generation cephalosporins and has a similar antibacterial spectrum, but with additional anti-anaerobe coverage. cefotetanclinical dataahfs/drugs.comconsumer drug informationroutes ofadministrationinjectionatc codej01dc05 (who) legal statuslegal status us: ℞-only identifiers iupac name (7s)-7--7-methoxy-3--8-oxo-5-thia-1-azabicyclooct-2-ene-2-carboxylic acid cas number69712-56-7 ypubchem cid53025drugbankdb01330 nchemspider47904 yunii48spp0pa9qkeggd00260 nchebichebi:3499 nchemblchembl474579 ncomptox dashboard (epa)dtxsid1022762 echa infocard100.067.337 chemical and physical dataformulac17h17n7o8s4molar mass575.60 g·mol−13d model (jsmol)interactive image smiles o=c2n1/c(=c(\cs12(oc)nc(=o)c3s/c(s3)=c(/c(=o)n)c(=o)o)csc4nnnn4c)c(=o)o inchi inchi=1s/c17h17n7o8s4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15h,3-4h2,1-2h3,(h2,18,25)(h,19,26)(h,27,28)(h,29,30)/b12-6-/t13?,15-,17+/m1/s1 ykey:srznhpxwxcnndu-ixopciaxsa-n y ny (what is this?) (verify) cefotetan was developed by yamanouchi. it is marketed outside japan by astrazeneca with the brand names apatef and cefotan. adverse effects the chemical structure of cefotetan, like that of several other cephalosporins, contains an n-methylthiotetrazole (nmtt or 1-mtt) side chain. as the antibiotic is broken down in the body, it releases free nmtt, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin k epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (antabuse), due to inhibition of aldehyde dehydrogenase. spectrum of bacterial susceptibility cefotetan has a broad spectrum of activity and has been used to treat bacterial infections of the bone, skin, urinary tract, and lower respiratory tract. notable species include bacteroides, streptococcus, and escherichia. the following represents mic susceptibility data for a few medically significant bacteria. escherichia coli: 0.06 µg/ml bacteroides fragilis: ≤0.06 µg/ml - 512 µg/ml clostridium perfringens: 1 µg/ml - 4 µg/ml