glufimet glufimet glufimet (developmental code name rgpu-238), also known as dimethyl 3-phenylglutamate hydrochloride, is a derivative of glutamic acid (glutamate) which was developed in russia and is related to the γ-aminobutyric acid (gaba) derivative phenibut (3-phenyl-gaba). it contains phenibut and glycine fragments in its chemical structure, has been described as a "gaba precursor", and is said to modulate the gaba and nitric oxide (no) systems and to have antioxidant activity. it has been suggested that metabotropic glutamate receptors may also play a role in the mechanism of action of glufimet. stress-protective effects have been described for glufimet in animals. glufimetclinical dataother namesrgpu-238; dimethyl 3-phenylglutamic acid hydrochloride; dimethyl 3-phenylglutamate hydrochloride; 1,5-dimethyl (2s)-2-amino-3-phenylpentanedioate hydrochlorideidentifiers iupac name dimethyl 2-amino-3-phenylpentanedioate;hydrochloride cas number651321-95-8pubchem cid78064435chemspider9646572comptox dashboard (epa)dtxsid00799548 chemical and physical dataformulac13h18clno4molar mass287.74 g·mol−13d model (jsmol)interactive image smiles coc(=o)cc(c1=cc=cc=c1)c(c(=o)oc)n.cl inchi inchi=1s/c13h17no4.clh/c1-17-11(15)8-10(12(14)13(16)18-2)9-6-4-3-5-7-9;/h3-7,10,12h,8,14h2,1-2h3;1hkey:yygzejcvumtamy-uhfffaoysa-n