serotonin–dopamine releasing agent serotonin–dopamine releasing agent a serotonin–dopamine releasing agent (sdra) is a type of drug which induces the release of serotonin and dopamine in the body and/or brain. further information: serotonin releasing agent and dopamine releasing agent a closely related type of drug is a serotonin–dopamine reuptake inhibitor (sdri). examples of sdras a number of tryptamine derivatives have been found to act as sdras. one such agent is 5-chloro-αmt (pal-542), which has been reported as having about 64-fold selectivity for dopamine release over norepinephrine release and about 3-fold selectivity for serotonin release over dopamine release, making it a highly selective and well-balanced sdra. another agent is 5-fluoro-αet (pal-545), which has about 35-fold selectivity for dopamine release over norepinephrine release and about 4-fold selectivity for serotonin release over dopamine release. though selective for inducing the release of serotonin and dopamine over norepinephrine, these agents are not selective monoamine releasers; they have all also been found to be potent agonists of the 5-ht2a receptor, and may act as agonists of other serotonin receptors as well. uwa-101 is an sdri that, based on its chemical structure, may also have a great efficacy as a releasing agent of serotonin and dopamine.