delmadinone acetate delmadinone acetate delmadinone acetate (dma), sold under the brand name tardak among others, is a progestin and antiandrogen which is used in veterinary medicine to treat androgen-dependent conditions such as benign prostatic hyperplasia. it must be used with care as it has the potential to cause adrenal insufficiency via inhibition of adrenocorticotropic hormone (acth) secretion from the pituitary gland. dma is the c17α acetate ester of delmadinone, which, in contrast to dma, was never marketed for medical use. delmadinone acetateclinical datatrade namestardak, othersother namesdma; rs-1310; 1-dehydrochlormadinone acetate; 1,6-didehydro-6-chloro-17α-acetoxyprogesterone; 6-chloro-17α-hydroxypregna-1,4,6-triene-3,20-dionedrug classprogestogen; progestin; progestogen ester; steroidal antiandrogenatcvet codeqg03dx91 (who) identifiers iupac name phenanthren-17-yl] acetate cas number13698-49-2pubchem cid10135765chemspider8311278unii92833m0ld9chemblchembl2104598comptox dashboard (epa)dtxsid60160018 echa infocard100.033.821 chemical and physical dataformulac23h27clo4molar mass402.92 g·mol−13d model (jsmol)interactive image smiles o=c\1\c=c/4(c(=c/1)c(\cl)=c/24cc3((oc(=o)c)(c(=o)c)cc23)c)c inchi inchi=1s/c23h27clo4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h5,8,11-12,16-18h,6-7,9-10h2,1-4h3/t16-,17+,18+,21-,22+,23+/m1/s1key:cgbcczzjvkuamx-dfxbjwiesa-n uses veterinary dma is used to treat androgen-dependent conditions in animals. it is most commonly used to treat benign prostatic hyperplasia. however, it can also be used to treat hypersexuality in male dogs and cats, perianal gland tumors in dogs, and hormone-driven aggression in dogs. pharmacology pharmacodynamics dma is a progestogen with antigonadotropic and hence antiandrogenic and antiestrogenic effects. in addition, dma binds to the androgen receptor, and likely acts as an antagonist of this receptor similarly to related drugs like chlormadinone acetate and osaterone acetate. chemistry