idiopathic scrotal calcinosis idiopathic scrotal calcinosis idiopathic scrotal calcinosis is a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus occurring on the scrotum.: 528 however, the levels of calcium and phosphate in the blood are normal. idiopathic scrotal calcinosis typically affects young males, with an onset between adolescence and early adulthood. the scrotal calcinosis appears, without any symptoms, as yellowish nodules that range in size from 1 mm to several centimeters. idiopathic scrotal calcinosisother namesidiopathic calcified nodules of the scrotumspecialtydermatology presentation single or multiple hard, marble-like nodules of varying size affecting scrotal skin. nodules vary in size from a few millimeters to a few centimeters. usually start to appear in childhood or early adult life over time, nodules increase in number and size nodules may break down and discharge chalky material rarely, lesions may be polypoid usually asymptomatic etiology the cause is not well defined. originally considered idiopathic condition. now accepted that majority of cases develop from dystrophic calcification of cyst contents. diagnostic clinically relevant pathologic features lesions slowly progress throughout life they slowly increase in number and size nodules are mobile and do not attach to underlying structures pathologic interpretation pearls globular and granular purple deposits within dermis surrounded by giant cell granulomatous reaction sometimes remnants of cystic lesion can be identified very distinctive appearance with almost no histologic differential diagnosis. treatment treatment may involve surgery, which is currently the only recommended intervention. surgery should include the removal of even small nodules, to prevent the recurrence of the scrotal calcinosis. prognosis benign condition slow progression throughout life lesions remain discrete and do not become confluent epidemiology incidence: uncommon age: children and young adults history scrotal calcinosis was first described in 1883 by lewinski.