chaetochromin chaetochromin chaetochromin, also known as 4548-g05, is an orally active, small-molecule, selective agonist of the insulin receptor. it has potent and long-lasting antidiabetic activity in vivo in mice. the drug may represent a novel potential therapeutic agent for the treatment of diabetes which is more convenient and tolerable to administer than injected insulin. it was discovered in 1981 in chaetomium gracile fungi, and its interaction with the insulin receptor was identified in 2014. chaetochrominclinical dataother names4548-g05identifiers iupac name 5,5',6,6',8,8'-hexahydroxy-2,2',3,3'-tetramethyl-2,2',3,3'-tetrahydro-4h,4'h-9,9'-bibenzochromene-4,4'-dione cas number75514-37-3pubchem cid53277chemspider48120uniiyme4gs90i1chemblchembl162783comptox dashboard (epa)dtxsid10910964 chemical and physical dataformulac30h26o10molar mass546.528 g·mol−13d model (jsmol)interactive image smiles cc1c(oc2cc3c(c(cc(c3c4c5cc6c(c(c5c(cc4o)o)o)c(=o)c(c(o6)c)c)o)o)c(c2c1=o)o)c inchi inchi=1s/c30h26o10/c1-9-11(3)39-19-5-13-21(15(31)7-17(33)23(13)29(37)25(19)27(9)35)22-14-6-20-26(28(36)10(2)12(4)40-20)30(38)24(14)18(34)8-16(22)32/h5-12,31-34,37-38h,1-4h3key:rhnvlfnwdgwacv-uhfffaoysa-n stereochemistry chaetochromin a and b are stereoisomers of this structure, while chaetochromin c and d are related but different compounds. it is not known whether the insulin mimetic effect was found in chaetochromin a or b, or in a mixture.