5-methoxytryptamine 5-methoxytryptamine 5-methoxytryptamine (5-mt), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-mt has been shown to occur naturally in the body in low levels. it is biosynthesized via the deacetylation of melatonin in the pineal gland. 5-methoxytryptamineidentifiers iupac name 2-(5-methoxy-1h-indol-3-yl)ethanamine cas number608-07-1 ypubchem cid1833iuphar/bps107chemspider1767 yunii3vmw6141kckeggc05659 ychebichebi:2089 ychemblchembl8165 ycomptox dashboard (epa)dtxsid60209638 echa infocard100.009.231 chemical and physical dataformulac11h14n2omolar mass190.246 g·mol−13d model (jsmol)interactive image smiles o(c1cc2c(cc1)cc2ccn)c inchi inchi=1s/c11h14n2o/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13h,4-5,12h2,1h3 ykey:jtejppkmybdemy-uhfffaoysa-n y (verify) 5-mt acts as a full agonist at the 5-ht1, 5-ht2, 5-ht4, 5-ht6, and 5-ht7 receptors. it has no affinity for the 5-ht3 receptor and its affinity for the 5-ht1e receptor is very weak in comparison to the other 5-ht1 receptors. its affinity for the 5-ht5a receptor is unknown. indorenate measured affinity for some receptors (incomplete list): 5-ht1b receptors (ki = 35 nm) 5-ht1d receptors (ki = 7.3 nm) 5-ht1e receptors (ki = 3151 nm) 5-ht1f receptors (ki = 1166 nm) 5-ht2a receptors (ki = 295 nm) 5-ht2b receptors (ki = 16.4 nm) 5-ht2c receptors (ki = 52.48 nm) 5-ht4 receptors (ki = 501.18 nm) 5-ht6 receptors (ki = 69.18 nm) 5-ht7 receptors (ki = 5.01 nm)