jimscaline jimscaline jimscaline (c-(4,5,6-trimethoxyindan-1-yl)methanamine) is a conformationally-restricted derivative of the cactus-derived hallucinogen mescaline, which was discovered in 2006 by a team at purdue university led by david e. nichols. it acts as a potent agonist for the 5-ht2a and 5-ht2c receptors with the more active (r)-enantiomer having a ki of 69 nm at the human 5-ht2a receptor, and around three times the potency of mescaline in drug-substitution experiments in animals. this discovery that the side chain of the phenethylamine hallucinogens could be constrained to give chiral ligands with increased activity then led to the later development of the super-potent benzocyclobutene derivative tcb-2. jimscalineclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status in general: uncontrolled identifiers iupac name (r)-(2,3-dihydro-4,5,6-trimethoxy-1h-inden-1-yl)aminomethane cas number890309-57-6 npubchem cid11673493chemspider9848222 ncomptox dashboard (epa)dtxsid30470414 chemical and physical dataformulac13h19no3molar mass237.299 g·mol−13d model (jsmol)interactive image smiles coc1=c(c(=c2cc(c2=c1)cn)oc)oc inchi inchi=1s/c13h19no3/c1-15-11-6-10-8(7-14)4-5-9(10)12(16-2)13(11)17-3/h6,8h,4-5,7,14h2,1-3h3/t8-/m0/s1 nkey:aftizghfdcoqfs-qmmmgpobsa-n n ny (what is this?) (verify)