25b-nbome 25b-nbome 25b-nbome (nbome-2c-b, cimbi-36, nova, bom 2-cb) is a derivative of the phenethylamine psychedelic 2c-b, discovered in 2004 by ralf heim at the free university of berlin. it acts as a potent full agonist for the 5ht2a receptor. anecdotal reports from users suggest 25b-nbome to be an active hallucinogen at a dose of as little as 250–500 µg, making it a similar potency to other phenethylamine derived hallucinogens such as bromo-dragonfly. duration of effects lasts about 12–16 hours, although the parent compound is rapidly cleared from the blood when used in the radiolabeled form in tracer doses. recently, custodio et al (2019) evaluated the potential involvement of dysregulated dopaminergic system, neuroadaptation, and brain wave changes which may contribute to the rewarding and reinforcing properties of 25b-nbome in rodents. 25b-nbomelegal statuslegal status de: anlage i (authorized scientific use only) uk: class a us: schedule i identifiers iupac name 2-(4-bromo-2,5-dimethoxyphenyl)-n-ethanamine cas number1026511-90-9 npubchem cid9977044chemspider8152636 yuniis6naa81phkcomptox dashboard (epa)dtxsid50907974 chemical and physical dataformulac18h22brno3molar mass380.282 g·mol−13d model (jsmol)interactive image smiles coc1=cc=cc=c1cnccc2=cc(=c(c=c2oc)br)oc inchi inchi=1s/c18h22brno3/c1-21-16-7-5-4-6-14(16)12-20-9-8-13-10-18(23-3)15(19)11-17(13)22-2/h4-7,10-11,20h,8-9,12h2,1-3h3 ykey:suxgnjvvbgjefb-uhfffaoysa-n y ny (what is this?) (verify) the carbon-11 labeled version of this compound (cimbi-36) was synthesized and validated as a radioactive tracer for positron emission tomography (pet) in copenhagen. as a 5-ht2a receptor agonist pet radioligand, cimbi-36 was hypothesized to provide a more functional marker of these receptors. also, cimbi-36 is investigated as a potential marker of serotonin release and thus could serve as an indicator of serotonin levels in vivo. cimbi-36 is now undergoing clinical trials as a pet-ligand in humans. toxicity and harm potential 25b-nbome has been used in clinical trials with an evaluation dose for safety consideration to humans of only 1 microgram. such a dose is only 1/300th the dose expected to be hallucinogenic to humans and it is expected that recreational use would greatly exceed doses determined to be safe to humans. one case has been reported on where 25b-nbome was identified as the cause of death for a 17-year-old male. the drug was also implicated in the death of an 18-year old male, however it was not reported whether the presence of the drug was confirmed postmortem. several deaths have been attributed to its close analogue 25i-nbome. analogues and derivatives analogues and derivatives of 2c-b: 25-n: 25b-n1pome 25b-nacpip 25-nb: 25b-nb 25b-nb23dm 25b-nb25dm 25b-nb3ome 25b-nb4ome 25b-nbf 25b-nbmd 25b-nboh 25b-nbome (nbome-2cb) dmbmpp 25-nm: 25b-nme7bf 25b-nme7bt 25b-nme7bim 25b-nme7box 25b-nme7dhbf 25b-nme7ind 25b-nme7indz 25b-nmepyr substituted benzofurans: 2c-b-fly 2c-b-butterfly 2c-b-dragonfly 2cbfly-nbome (nbome-2cb-fly) dob-fly n-(2c)-fentanyl: n-(2c-b) fentanyl n-(2c-b-fly) fentanyl other: bob boh-2c-b, β-hydroxy-2c-b, βoh-2cb bmb 2c-b-5-hemifly 2c-b-aminorex (2c-b-ar) 2c-b-an 2c-b-bzp 2c-b-fly-nb2eto5cl 2c-b-pp 2cb-ind βk-2c-b (beta-keto 2c-b) n-ethyl-2c-b tcb-2 (2c-bcb) legal status canada as of october 31, 2016; 25b-nbome is a controlled substance (schedule iii) in canada. russia banned as a narcotic drug since may 5, 2015. sweden in sweden, the riksdag added 25b-nbome to schedule i ("substances, plant materials and fungi which normally do not have medical use") as narcotics in sweden as of august 1, 2013, published by the medical products agency in their regulation lvfs 2013:15 listed as 25b-nbome 2-(4-bromo-2,5-dimetoxifenyl)-n-(2-metoxibensyl)etanamin. united kingdom this substance is a class a drug in the united kingdom as a result of the n-benzylphenethylamine catch-all clause in the misuse of drugs act 1971. united states in november 2013, the u.s. drug enforcement administration placed 25b-nbome (along with 25i-nbome and 25c-nbome) in schedule i of the controlled substances act, making it illegal to manufacture, buy, possess, process, or distribute. china as of october 2015 25b-nbome is a controlled substance in china. czech republic 25b-nbome is banned in the czech republic.