lenz–majewski syndrome lenz–majewski syndrome lenz–majewski syndrome (lms), also known as lenz–majewski hyperostotic dwarfism (lmhd), is a skin condition characterized by hyperostosis, craniodiaphyseal dysplasia, dwarfism, cutis laxa, proximal symphalangism, syndactyly, brachydactyly, intellectual disability, enamel hypoplasia and hypertelorism.: 571 lenz–majewski syndromeother nameslenz–majewski hyperostotic dwarfism (lmhd) genetics in 2013, whole-exome sequencing showed that a missense mutation resulting in overactive phosphatidylserine synthase 1 was the cause of lms, making it the first known human disease to be caused by disrupted phosphatidylserine metabolism. the researchers suggested a link between the condition and bone metabolism.