indoramin indoramin indoramin (trade names baratol and doralese) is a piperidine antiadrenergic agent. indoraminclinical dataahfs/drugs.cominternational drug namesatc codec02ca02 (who) identifiers iupac name n-benzamide cas number26844-12-2 npubchem cid33625iuphar/bps501drugbankdb08950 nchemspider31014 yunii0z802hmy7hkeggd04531 ychemblchembl279516 ycomptox dashboard (epa)dtxsid7048370 echa infocard100.043.659 chemical and physical dataformulac22h25n3omolar mass347.462 g·mol−13d model (jsmol)interactive image smiles o=c(c1ccccc1)nc4ccn(ccc3c2ccccc2c3)cc4 inchi inchi=1s/c22h25n3o/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23h,10-15h2,(h,24,26) ykey:jxzzexzzkawdsp-uhfffaoysa-n y ny (what is this?) (verify) it is an alpha-1 selective adrenoceptor antagonist with direct myocardial depression action; therefore, it results in no reflex tachycardia. it is also used in benign prostatic hyperplasia (bph). it is commonly synthesized from tryptophol. dosage indoramin is commonly prescribed as 20 mg tablets when used in bph. side effects drowsiness, dizziness, dry mouth, nasal congestion, headache, fatigue, weight gain, hypotension, postural hypotension, depression, problems with ejaculation, diarrhoea, nausea, increased need to pass urine, and palpitations. synthesis tryptamine and serotonin are naturally occurring indole ethylamino compounds with pronounced pharmacological activities. they have served as the inspiration for synthesis of numerous analogues. however, on may 31, 2013, the french national agency for the safety of medicines and health products (ansm) concluded that the benefit/risk ratio of this product was unfavorable and withdrew vidora's marketing authorization and recalled its batches from the market on june 3, 2013. α1-adrenergic blocking agent with antihypertensive and bronchodilating activity. prepn: one such study involved alkylation of 4-benzamidopyridine (2) with 3-(2-bromoethyl)-1h-indole (1) to give a quaternary salt (3); this intermediate was in turn hydrogenated with a raney nickel catalyst to give indoramine (4).