vchsr vchsr vchsr is a drug used in scientific research which acts as a selective antagonist of the cannabinoid receptor cb1. it is derived from the widely used cb1 antagonist rimonabant, and has similar potency and selectivity for the cb1 receptor, but has been modified to remove the hydrogen bonding capability in the c-3 substituent region, which removes the inverse agonist effect that rimonabant produces at high doses, so that vchsr instead acts as a neutral antagonist, blocking the receptor but producing no physiological effect of its own. vchsridentifiers iupac name 5-(4-chlorophenyl)- 3-- 1-(2,4-dichlorophenyl)- 4-methyl- 1h-pyrazole chemspider21378331chemical and physical dataformulac24h23cl3n2molar mass445.811 g·mol−13d model (jsmol)interactive image smiles c4ccccc4c=cc(c(c)c1-c(cc3)ccc3cl)nn1-c2ccc(cl)cc2cl inchi inchi=1s/c24h23cl3n2/c1-16-22(13-7-17-5-3-2-4-6-17)28-29(23-14-12-20(26)15-21(23)27)24(16)18-8-10-19(25)11-9-18/h7-15,17h,2-6h2,1h3/b13-7+key:umolsrbhnlxwgd-ntuhnpausa-n (verify)