progesterone 3-acetyl enol ether progesterone 3-acetyl enol ether progesterone 3-acetyl enol ether, also known as progesterone acetate, as well as 3-acetoxypregna-3,5-dien-20-one, is a progestin which was never marketed. it was reported to possess similar potency to progesterone and hydroxyprogesterone caproate in the rabbit endometrial carbonic anhydrase test, a bioassay of progestogenic activity. in addition, it was able to maintain pregnancy in animals. progesterone 3-acetyl enol ether is closely related to quingestrone, which is also known as progesterone 3-cyclopentyl enol ether and was formerly marketed as an oral contraceptive. progesterone 3-acetyl enol etherclinical dataother namesprogesterone acetate; progesterone 3-acetate; 3-acetoxypregna-3,5-diene-20-one; 20-oxopregna-3,5-dien-3-yl acetate; 3,5-progesterol acetate; nsc-124740drug classprogestogen; progestogen etheridentifiers iupac name phenanthren-3-yl] acetate cas number4954-06-7 ypubchem cid134580chemspider118613unii7rb32a7qsdchemical and physical dataformulac23h32o3molar mass356.506 g·mol−13d model (jsmol)interactive image smiles cc(=o)1cc21(cc32cc=c43(ccc(=c4)oc(=o)c)c)c inchi inchi=1s/c23h32o3/c1-14(24)19-7-8-20-18-6-5-16-13-17(26-15(2)25)9-11-22(16,3)21(18)10-12-23(19,20)4/h5,13,18-21h,6-12h2,1-4h3/t18-,19+,20-,21-,22-,23+/m0/s1key:yipyjrprhujjdp-wkolouimsa-n the 3-acetyl ether may be cleaved from progesterone 3-acetyl enol ether in vivo and, based on its chemical structure, this may result in the transformation of progesterone 3-acetyl enol ether into 3α-dihydroprogesterone and/or 3β-dihydroprogesterone. 3β-dihydroprogesterone has been reported to possess about the same progestogenic potency as progesterone in the clauberg test, whereas 3α-dihydroprogesterone was not assessed. the c3 enol ethers of progesterone are less suited for use via depot injection relative to progestogen esters like hydroxyprogesterone caproate due to their susceptibility to oxidative metabolism.