renanolone renanolone renanolone (inn), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a synthetic neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use. its isomers, alfaxolone and alfadolone, are also general anesthetics, and are known to act as positive allosteric modulators of the gabaa receptor, a property which is likely the case for renanolone as well. renanoloneclinical dataatc codenoneidentifiers iupac name 3α-hydroxy-5β-pregnane-11,20-dione cas number565-99-1pubchem cid68930chemspider16736755uniid8z6e4ir2jchemical and physical dataformulac20h30o4molar mass334.456 g·mol−13d model (jsmol)interactive image smiles cc(=o)1cc23cc4c(o)cc4(o)3c(=o)c12c inchi inchi=1s/c20h30o4/c1-11(21)15-5-6-16-14-4-3-12-9-13(22)7-8-20(12,24)18(14)17(23)10-19(15,16)2/h12-16,18,22,24h,3-10h2,1-2h3/t12-,13-,14+,15-,16+,18-,19-,20-/m1/s1key:icicfvfepdwwaq-mnywxnlxsa-n chemistry