metaraminol metaraminol metaraminol, previously sold under the brand name aramine among others and also known as metaradrine, is a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. it is an α1-adrenergic receptor agonist with some β effect. it is currently sold in its generic form by slayback pharma. metaraminolclinical datatrade namesaramine, metaramin, pressonexahfs/drugs.cominternational drug nameslicense data us dailymed: metaraminol pregnancycategory au: c routes ofadministrationintravenous, endotrachealatc codec01ca09 (who) legal statuslegal status au: s4 (prescription only) uk: pom (prescription only) us: ℞-only pharmacokinetic databioavailabilityn/aprotein binding~45%metabolismliveridentifiers iupac name (1r,2s)-3-phenol cas number54-49-9 y 33402-03-8 (bitartrate)pubchem cid5906iuphar/bps7229drugbankdb00610 ychemspider5695 yunii818u2pz2ehkeggd08192 ychebichebi:6794 ychemblchembl1201319 ncomptox dashboard (epa)dtxsid8023268 chemical and physical dataformulac9h13no2molar mass167.208 g·mol−13d model (jsmol)interactive image smiles o(c1cc(o)ccc1)(n)c inchi inchi=1s/c9h13no2/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6,9,11-12h,10h2,1h3/t6-,9-/m0/s1 ykey:wxfigdlssyikkv-rcovlwmosa-n y ny (what is this?) (verify) pharmacology and use as a vasopressor metaraminol is given intravenously as either a bolus (often 0.5-1mg doses) or as an infusion, usually via peripheral intravenous access. metaraminol is commonly available as 10mg in 1ml, that requires dilution prior to administration (often made up to a 0.5mg/ml solution), however pre-prepared syringes of metaraminol for bolus use for hypotension are also commonly available. a commercially prepared pre-filled syringe of metaraminol for bolus use during anaesthesia, made up as 0.5mg/ml (2.5mg in 5ml). pharmacodynamics the dominant mechanism for the vasopressor action of metaraminol is indirect, with metaraminol displacing noradrenaline from neuronal vesicles in order for the noradrenaline to exert its vasopressor action. metaraminol at higher doses may have direct alpha-adrenergic agonist and beta-1 adrenergic agonist effects. however at doses common in clinical practice, the indirect alpha-1 adrenergic effects predominate, such that reflex bradycardia is a common side-effect. research metaraminol is also used in the treatment of priapism.