collagenous spherulosis collagenous spherulosis collagenous spherulosis, or simple spherulosis, is a benign finding in breast pathology. it is almost always an incidental finding, though it is occasionally associated with calcifications, which may lead to a biopsy. collagenous spherulosisother namesmucinous spherulosis, spherulosismicrograph of collagenous spherulosis with the characteristic histomorphology - intratubular eosinophilic material with a spoke-like arrangement. h&e stain.specialtypathology significance it is important to correctly identify, as it can be confused with atypical ductal hyperplasia, cribriform ductal carcinoma in situ (dcis), and adenoid cystic carcinoma. histomorphologic features collagenous spherulosis is characterized by a tubular/cribriform architecture with intratubular eosinophilic material that classically is arranged like the spokes of a wheel ("radial spikes"). there is usually no mitotic activity, and two cells populations (epithelial & myoepithelial) are present, like in benign breast glands. the lesions are typically small (less than 50 spherules per lesion, less than 100 micrometers in size) and may be multifocal. intermed. mag. high mag.