uterine clear-cell carcinoma uterine clear-cell carcinoma uterine clear-cell carcinoma (cc) is a rare form of endometrial cancer with distinct morphological features on pathology; it is aggressive and has high recurrence rate. like uterine papillary serous carcinoma cc does not develop from endometrial hyperplasia and is not hormone sensitive, rather it arises from an atrophic endometrium. such lesions belong to the type ii endometrial cancers. uterine clear-cell carcinomaspecialtygynecology, oncology diagnosis the lesion is found in patients who present typically with abnormal or postmenopausal bleeding or discharge. such bleeding is followed by further evaluation leading to a tissue diagnosis, usually done by a dilatation and curettage (d&c). a work-up to follow would look for metastasis using imaging technology including sonography and mri. the median age at diagnosis in a large study was 66 years. histologically the lesion may coexist with classical endometrial cancer. treatment prognosis of the cc is affected by age, stage, and histology as well as treatment the primary treatment is surgical. figo-cancer staging is done at the time of surgery which consists of peritoneal cytology, total hysterectomy, bilateral salpingo-oophorectomy, pelvic/para-aortic lymphadenectomy, and omentectomy. the tumor is aggressive and spreads quickly into the myometrium and the lymphatic system. thus even in presumed early stages, lymphadenectomy and omentectomy should be included in the surgical approach. if the tumor has spread surgery is cytoreductive followed by radiation therapy and/or chemotherapy. the five years survival was reported to be 68%. staging uterine clear-cell carcinoma is staged like other forms of endometrial carcinoma at time of surgery using the international federation of gynecology and obstetrics (figo) cancer staging system 2009. ia tumor confined to the uterus, no or < 1⁄2 myometrial invasion ib tumor confined to the uterus, > 1⁄2 myometrial invasion ii cervical stromal invasion, but not beyond uterus iiia tumor invades serosa or adnexa iiib vaginal and/or parametrial involvement iiic1 pelvic node involvement iiic2 para-aortic involvement iva tumor invasion bladder and/or bowel mucosa ivb distant metastases including abdominal metastases and/or inguinal lymph nodes