iotapapillomavirus iotapapillomavirus iotapapillomavirus is a genus of viruses, in the family papillomaviridae. rodents serve as natural hosts. there are two species in this genus. diseases associated with this genus include: cutaneous lesions and benign skin tumours, such as papillomas and keratoacanthomas. iotapapillomavirus virus classification (unranked): virus realm: monodnaviria kingdom: shotokuvirae phylum: cossaviricota class: papovaviricetes order: zurhausenvirales family: papillomaviridae genus: iotapapillomavirus taxonomy the following two species are assigned to the genus: iotapapillomavirus 1 iotapapillomavirus 2 structure viruses in iotapapillomavirus are non-enveloped, with icosahedral geometries, and t=7 symmetry. the diameter is around 60 nm. genomes are circular, around 8kb in length. genusstructuresymmetrycapsidgenomic arrangementgenomic segmentation iotapapillomavirusicosahedralt=7non-envelopedcircularmonopartite life cycle viral replication is nuclear. entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. replication follows the dsdna bidirectional replication model. dna-templated transcription, with some alternative splicing mechanism is the method of transcription. the virus exits the host cell by nuclear envelope breakdown. rodents serve as the natural host. transmission routes are contact. genushost detailstissue tropismentry detailsrelease detailsreplication siteassembly sitetransmission iotapapillomavirusrodentsepithelial: mucous; epithelial: skincell receptor endocytosislysisnucleusnucleuscontact