large-cell lymphoma large-cell lymphoma the large-cell lymphomas have large cells. one classification system for lymphomas divides the diseases according to the size of the white blood cells that have turned cancerous. a large cell, in this context, has a diameter of 17 to 20 μm. other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas. large-cell lymphomamicrograph of a primary mediastinal large b-cell lymphoma, a type of large-cell lymphoma. h&e stain.specialtyoncology types b cell diffuse large b-cell lymphoma is the most common of the large-cell lymphomas. mesh now classifies the phrase "large-cell lymphoma" under "diffuse large b cell lymphoma". many other b-cell lymphomas feature large cells: angiocentric lymphoma burkitt's lymphoma follicular large-cell lymphoma immunoblastic lymphoma intravascular large-cell lymphoma primary mediastinal b-cell lymphoma t-cell–rich b-cell lymphoma primary splenic lymphoma (rare) primary central nervous system lymphomas, which are often diffuse large-b-cell lymphomas richter's transformation: diffuse large b-cell variant 1) abc subtype (common) 2) gcb subtype (rare) activated b-cell diffuse large b-cell lymphoma, or abc-dlbcl, is believed to be caused by aberrant activation of a critical intracellular pathway. this intracellular signaling pathway involved in b-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously. the inhibition of this pathway can be induced by a drug known as nemo binding domain, or nbd, a peptide causing increased cell death of malignant lymphocytes. t cell less commonly, a large-cell lymphoma may feature t cells. anaplastic large-cell lymphoma is an example of a large-cell lymphoma that involves t cells. of the large-cell t-cell lymphomas, it has the best prognosis.