naive b cell naive b cell a naive b cell is a b cell that has not been exposed to an antigen. these are located in the tonsils, spleen, primary lymphoid follicles in lymph nodes once exposed to an antigen, the naive b cell either becomes a memory b cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound. plasma cells do not last long in the circulation, this is in contrast to memory cells that last for very long periods of time. memory cells do not secrete antibody until activated by their specific antigen. notes and references airoldi i, raffaghello l, cocco c, et al. (january 2004). "heterogeneous expression of interleukin-18 and its receptor in b-cell lymphoproliferative disorders deriving from naive, germinal center, and memory b lymphocytes". clin. cancer res. 10 (1 pt 1): 144–54. doi:10.1158/1078-0432.ccr-1026-3. pmid 14734463. lang ml (aug 2009). "how do natural killer t cells help b cells?". expert rev vaccines. 8 (8): 1109–21. doi:10.1586/erv.09.56. pmc 2747240. pmid 19627191. lymphocytesb cells b1 cell plasmablast plasma memory follicular marginal zone naïve pre-b breg cell b10 cell transitional b cell lymphoplasmacytoid cell t cells thymocyte αβ (cytotoxic cd8+ helper cd4+ / tfh / th3 / th17 / regulatory) naïve memory t cell tcm tem trm tvm innate-like t cells natural killer t cell γδ mucosal associated invariant t cell innate lymphoid cellsnk cells cytokine-induced killer cell lymphokine-activated killer cell null cell adaptive nk cell uterine natural killer cells type 1 innate lymphoid cells type 2 innate lymphoid cells nuocytes type 3 innate lymphoid cells lti cells lymphopoiesis hematopoietic stem cell lymphoblast prolymphocyte this article is issued from wikipedia. the text is licensed under creative commons - attribution - sharealike. additional terms may apply for the media files.