cumyl-4cn-binaca cumyl-4cn-binaca cumyl-4cn-binaca (also known as cumyl-cybinaca or sgt-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug. it is a potent agonist for cannabinoid receptors cb1 and cb2, with in vitro ec50 values of 0.58 nm and 6.12 nm, respectively. in mice, cumyl-4cn-binaca produces hypothermic and pro-convulsant effects via the cb1 receptor, and anecdotal reports suggest it has an active dose of around 0.1 mg in humans. cumyl-4cn-binacalegal statuslegal status au: s9 (prohibited substance) ca: schedule ii de: anlage ii (authorized trade only, not prescriptible) uk: class b us: schedule i identifiers iupac name 1-(4-cyanobutyl)-n-(2-phenylpropan-2-yl)-1h-indazole-3-carboxamide cas number1631074-54-8pubchem cid117650402chemspider58190345uniiv6dm582rv1comptox dashboard (epa)dtxsid401009982 chemical and physical dataformulac22h24n4omolar mass360.461 g·mol−13d model (jsmol)interactive image smiles o=c(nc(c)(c)c1=cc=cc=c1)c2=nn(ccccc#n)c3=c2c=cc=c3 inchi inchi=1s/c22h24n4o/c1-22(2,17-11-5-3-6-12-17)24-21(27)20-18-13-7-8-14-19(18)26(25-20)16-10-4-9-15-23/h3,5-8,11-14h,4,9-10,16h2,1-2h3,(h,24,27)key:jgtsowopisvahg-uhfffaoysa-n cumyl-4cn-binaca is metabolized to produce cyanide, raising concerns about liver toxicity. there is one reported case of hyperthermia, rhabdomyolysis, and kidney failure associated with its use.