nicosan nicosan nicosan, also known as hemoxin, niprisan, or nix-0699, is a phytochemical which was studied in sickle-cell disease (scd). as of 2017 it does not appear to be commercially available, as the only manufacturer, which was is in nigeria, has stopped making it due to financial problems. medical uses there is tentative evidence that it may be useful in sickle-cell disease. it however does not appear to affect overall complications or rates of anemia. chemistry it is an ethanol/water extract of piper guineense seeds, pterocarpus osum stem, eugenia caryophyllus fruit, and sorghum bicolor leaves. history it was developed at the nigerian national institute for pharmaceutical research and development (niprd) (u.s. patent # 5,800,819 - september 1, 1998). niprd is conducted a phase iii clinical trials in nigeria which showed unclear benefit but have not been published as of 2010. in august 2002, a nigerian subsidiary of the american company xechem international, acquired the rights to nicosan. on july 6, 2006, the drug was announced in nigeria, with the president of nigeria, olusegun obasanjo, in attendance. in 2008, a fraud complaint alleged nigerian public money was spent on the drug. xechem international went bankrupt in 2008 and production of the drug stopped. footnotes oniyangi, oluseyi; cohall, damian h. (25 september 2020). "phytomedicines (medicines derived from plants) for sickle cell disease". the cochrane database of systematic reviews. 9: cd004448. doi:10.1002/14651858.cd004448.pub7. issn 1469-493x. pmc 8106534. pmid 32977351. "neglect of traditional medicine continues". retrieved 12 september 2018. kotiah, sd; ballas, sk (december 2009). "investigational drugs in sickle cell anemia". expert opinion on investigational drugs. 18 (12): 1817–28. doi:10.1517/13543780903247463. pmid 19780709. ndhlovu, deborah-fay (18 november 2010). "funding woes afflict african herbal therapy institute". nature. doi:10.1038/news.2010.602. retrieved 12 september 2018. "sickle cell drug mired in controversy". sci dev net. june 30, 2008. retrieved june 4, 2017. "nigerian research institute commences production of sickle cell anaemia management drug - nigerian bulletin - trending news". nigerian bulletin - trending news. retrieved 12 september 2018. this article is issued from wikipedia. the text is licensed under creative commons - attribution - sharealike. additional terms may apply for the media files.