biphenylindanone a biphenylindanone a biphenylindanone a (bina, ls-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group ii metabotropic glutamate receptor subtype mglur2. biphenylindanone aclinical dataatc codenoneidentifiers iupac name 3’-(((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro- 1h-inden-5-yl)oxy)methyl)biphenyl-4-carboxylic acid cas number866823-73-6 ypubchem cid9868580iuphar/bps3954chemspider8044271 ychemblchembl593013 ycomptox dashboard (epa)dtxsid90432098 chemical and physical dataformulac30h30o4molar mass454.566 g·mol−13d model (jsmol)interactive image smiles c3cc(c(o)=o)ccc3-c(ccc4)cc4coc(c1c)cc(c(c2=o)c1c)cc2c5cccc5 inchi inchi=1s/c30h30o4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26h,3-4,7-8,15,17h2,1-2h3,(h,32,33) ykey:kmkbeesnzapkmp-uhfffaoysa-n y (verify) in animal studies it showed anxiolytic and antipsychotic effects, and blocked the effects produced by the hallucinogenic drug dob. bina and other selective mglur2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs. bina decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mglur2/3 agonist ly-379,268.