non-islet cell tumor hypoglycemia non-islet cell tumor hypoglycemia non-islet cell tumor hypoglycemia is a condition in which a tumor secretes hormones into the bloodstream that cause hypoglycemia. the is most commonly insulin-like growth factor 2, which stimulates insulin receptors to uptake glucose into cells. non-islet cell tumor hypoglycemiaspecialtyoncology many types of non-islet cell tumors can cause this phenomenon, but not all act through the same mechanism. rarely, non-islet tumors can secrete igf-1 or insulin.