list of cutaneous conditions caused by mutations in keratins list of cutaneous conditions caused by mutations in keratins there are many different keratin proteins normally expressed in the human integumentary system. mutations in keratin proteins in the skin can cause disease. cutaneous conditions caused by mutations in keratin proteins defective keratin typecondition(s) 1epidermolytic hyperkeratosisichthyosis hystrix of curth–macklindiffuse nonepidermolytic palmoplantar keratoderma (unna–thost keratoderma)diffuse epidermolytic palmoplantar keratoderma (vörner keratoderma) 2 (2e)ichthyosis bullosa of siemens 3meesmann corneal dystrophy 4white sponge nevus 5epidermolysis bullosa simplexdowling–degos' diseaseolmsted syndrome 6apachyonychia congenita type i 6bpachyonychia congenita type ii 7 8 9diffuse epidermolytic palmoplantar keratoderma (vörner keratoderma) 10epidermolytic hyperkeratosisichthyosis with confettiichthyosis hystrix 11 12meesmann corneal dystrophy 13white sponge nevus 14epidermolysis bullosa simplexnaegeli–franceschetti–jadassohn syndromedermatopathia pigmentosa reticularisolmsted syndrome 15 16pachyonychia congenita type i 17pachyonychia congenita type iisteatocystoma multiplexvellus hair cyst 81monilethrix 82alopecia areata 83monilethrix 85pure hair–nail type of ectodermal dysplasia 86monilethrix