trafermin trafermin trafermin (brand name fiblast), also known as recombinant human basic fibroblast growth factor (rhbfgf), is a recombinant form of human basic fibroblast growth factor (bfgf) which is marketed in japan as a topical spray for the treatment of skin ulcers. it is also currently in preregistration for the treatment of periodontitis. as a recombinant form of bfgf, trafermin is a potent agonist of the fgfr1, fgfr2, fgfr3, and fgfr4. the drug has been marketed in japan since june 2001. traferminclinical datatrade namesfiblastother namescab-2001; recombinant human basic fibroblast growth factor; rhbfgf; 2-155-basic fibroblast growth factor (human clone lambdakb7/lambdahfl1 precursor reduced)routes ofadministrationtopical (spray)atc coded03ax15 (who) identifierscas number131094-16-1pubchem sid17397511chemspidernoneunii333ox80x87keggd03362chemical and physical dataformulac764h1201n217o219s6molar mass17122.67 g·mol−1