sb-649,915 sb-649,915 sb-649,915 is a serotonin reuptake inhibitor and 5-ht1a and 5-ht1b receptor antagonist which is being investigated for its antidepressant effects. relative to the selective serotonin reuptake inhibitors (ssris), sb-649,915 has a faster onset of action and may also have greater clinical efficacy as well. this can be attributed to blockade of 5-ht1a and 5-ht1b autoreceptors which inhibit serotonin release. sb-649,915clinical dataatc codenonelegal statuslegal status in general: uncontrolled identifiers iupac name 6-piperidin-4-yl)methyl]-4h-1,4-benzoxazin-3-one cas number420785-70-2 npubchem cid10225553iuphar/bps76chemspider8471882 nuniihd3uv2mfj8chemblchembl183460 nchemical and physical dataformulac26h29n3o3molar mass431.536 g·mol−13d model (jsmol)interactive image smiles o=c4coc1ccc(cc1n4)cc(cc5)ccn5ccoc(cccc2n3)c2ccc3c inchi inchi=1s/c26h29n3o3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19h,9-15,17h2,1h3,(h,28,30) nkey:pjsuyrbcbfpcqw-uhfffaoysa-n n ny (what is this?) (verify)