of oral antigen exposure, lack of early exposure to microbes, and an altered microbiome. a study comparing active eoe children to non eoe children found an altered microbiome due to a positive correlation between a relatively high abundance of haemophilus and disease activity seen through an increasing eosinophilic esophagitis endoscopic reference score and eosinophilic esophagitis histologic scoring system (q value = 5e-10). measuring the relative abundance of specific taxa in children’s salivary microbiome could serve as a noninvasive marker for eosinophilic esophagitis. history the first case of eosinophilic esophagitis was reported in 1978. in the early 1990s, it became recognized as a distinct disease.