7,8,3'-trihydroxyflavone 7,8,3'-trihydroxyflavone 7,8,3′-trihydroxyflavone (7,8,3'-thf) is a flavone and small-molecule agonist of trkb, the main receptor of brain-derived neurotrophic factor (bdnf), that was derived from tropoflavin (7,8-dhf). relative to tropoflavin, 7,8,3'-thf is 2–3-fold more potent in vitro as a trkb agonist. 7,3’-dihydroxyflavone (7,3'-dhf) is also more potent than tropoflavin in vitro, indicating that a 3'-hydroxy group on the b-ring enhances trkb agonistic activity. 7,8,3'-thf has been tested in vivo and was found to produce trkb-dependent neuroprotective effects in mice similarly to tropoflavin. 7,8,3'-trihydroxyflavoneclinical dataother names7,8,3'-thfatc codenoneidentifiers iupac name 7,8-dihydroxy-2-(3-hydroxyphenyl)chromen-4-one cas number137502-84-2pubchem cid676310chemspider589045uniif67b8s3mh9chemblchembl225513comptox dashboard (epa)dtxsid00350274 chemical and physical dataformulac15h10o5molar mass270.240 g·mol−13d model (jsmol)interactive image smiles c1=cc(=cc(=c1)o)c2=cc(=o)c3=c(o2)c(=c(c=c3)o)o inchi inchi=1s/c15h10o5/c16-9-3-1-2-8(6-9)13-7-12(18)10-4-5-11(17)14(19)15(10)20-13/h1-7,16-17,19hkey:zjzsqgdocuhccw-uhfffaoysa-n