jwh-150 jwh-150 jwh-150 ((1-butyl-5-phenylpyrrol-3-yl)-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the cb1 (ki = 60 ± 1nm) and cb2 (ki = 15 ± 2nm) receptors, with a moderate (4x) selectivity for the cb2 receptor. jwh-150 was first synthesized in 2006 by john w. huffman and colleagues to examine the nature of ligand binding to the cb1 receptor. jwh-150legal statuslegal status ca: schedule ii uk: class b identifiers iupac name (1-butyl-5-phenylpyrrol-3-yl)-naphthalen-1-ylmethanone cas number914458-18-7 ypubchem cid44418303chemspider23277877 ychemical and physical dataformulac25h23nomolar mass353.465 g·mol−13d model (jsmol)interactive image smiles ccccn1c=c(c=c1c2=cc=cc=c2)c(=o)c3=cc=cc4=cc=cc=c43 inchi inchi=1s/c25h23no/c1-2-3-16-26-18-21(17-24(26)20-11-5-4-6-12-20)25(27)23-15-9-13-19-10-7-8-14-22(19)23/h4-15,17-18h,2-3,16h2,1h3 ykey:ptiaqhrjoqemco-uhfffaoysa-n y legality in the united states jwh-150 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of jwh-150. in canada, jwh-150 and other naphthoylpyrrole-based cannabinoids are schedule ii controlled substances under the controlled drugs and substances act. in the united kingdom, jwh-150 and other naphthoylpyrrole-based cannabinoids are considered class b drugs under the misuse of drugs act 1971.