l-733,060 l-733,060 l-733,060 is a drug developed by merck which acts as an orally active, non-peptide, selective antagonist for the nk1 receptor, binding with a ki of 0.08 nm. only one enantiomer is active which has made it the subject of several asymmetric synthesis efforts. l-733,060clinical dataatc codenoneidentifiers iupac name (2s,3s)-3--2-phenylpiperidine cas number148700-85-0 ypubchem cid132846chemspider117244 nuniipk8cg2b44uchemblchembl27006 ncomptox dashboard (epa)dtxsid80933463 chemical and physical dataformulac20h19f6nomolar mass403.368 g·mol−13d model (jsmol)interactive image smiles c1ccc(cc1)2(cccn2)occ3cc(cc(c3)c(f)(f)f)c(f)(f)f inchi inchi=1s/c20h19f6no/c21-19(22,23)15-9-13(10-16(11-15)20(24,25)26)12-28-17-7-4-8-27-18(17)14-5-2-1-3-6-14/h1-3,5-6,9-11,17-18,27h,4,7-8,12h2/t17-,18-/m0/s1 nkey:fcdrfvcgmluypg-rouuacijsa-n n ny (what is this?) (verify) l-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. it shows anti-inflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury. it also has anticancer effects in a variety of in vitro models.