indeloxazine indeloxazine indeloxazine (inn) (elen, noin) is an antidepressant and cerebral activator that was marketed in japan and south korea by yamanouchi pharmaceutical co., ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, namely depression resulting from stroke, emotional disturbance, and avolition. it was marketed from 1988 to 1998, when it was removed from the market reportedly for lack of effectiveness. indeloxazineclinical dataother namesci-874, ym-08054atc codenonelegal statuslegal status discontinued identifiers iupac name 2-(3h-inden-4-yloxymethyl)morpholine cas number60929-23-9 ypubchem cid3704chemspider3576 yunii834m09r1kmkeggd08077 ycomptox dashboard (epa)dtxsid30866833 chemical and physical dataformulac14h17no2molar mass231.295 g·mol−13d model (jsmol)interactive image smiles o(c1cccc2\c=c/cc12)cc3occnc3 inchi inchi=1s/c14h17no2/c1-3-11-4-2-6-14(13(11)5-1)17-10-12-9-15-7-8-16-12/h1-4,6,12,15h,5,7-10h2 ykey:madrvgbadlfhmo-uhfffaoysa-n y (verify) indeloxazine acts as a serotonin releasing agent, norepinephrine reuptake inhibitor, and nmda receptor antagonist. it has been found to enhance acetylcholine release in the rat forebrain through activation of the 5-ht4 receptor via its action as a serotonin releasing agent. the drug has been found to possess nootropic, neuroprotective, anticonvulsant, and antidepressant-like effects in animal models.