chromosome 4 chromosome 4 chromosome 4 is one of the 23 pairs of chromosomes in humans. people normally have two copies of this chromosome. chromosome 4 spans more than 193 million base pairs (the building material of dna) and represents between 6 and 6.5 percent of the total dna in cells. chromosome 4human chromosome 4 pair after g-banding. one is from mother, one is from father.chromosome 4 pair in human male karyogram.featureslength (bp)193,574,945 bp(chm13)no. of genes727 (ccds)typeautosomecentromere positionsubmetacentric(50.0 mbp)complete gene listsccdsgene listhgncgene listuniprotgene listncbigene listexternal map viewersensemblchromosome 4entrezchromosome 4ncbichromosome 4ucscchromosome 4full dna sequencesrefseqnc_000004 (fasta) genbankcm000666 (fasta) genomics the chromosome is ~193 megabases in length. in a 2012 paper, 775 protein-encoding genes were identified on this chromosome. 211 (27.9%) of these coding sequences did not have any experimental evidence at the protein level, in 2012. 271 appear to be membrane proteins. 54 have been classified as cancer-associated proteins. genes number of genes the following are some of the gene count estimates of human chromosome 4. because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). among various projects, the collaborative consensus coding sequence project (ccds) takes an extremely conservative strategy. so ccds's gene number prediction represents a lower bound on the total number of human protein-coding genes. estimated by protein-coding genes non-coding rna genes pseudogenes source release date ccds727—— 2016-09-08 hgnc731277633 2017-05-12 ensembl746993727 2017-03-29 uniprot765—— 2018-02-28 ncbi769934819 2017-05-19 gene list the following is a partial list of genes on human chromosome 4. for complete list, see the link in the infobox on the right. aasdh: aminoadipate-semialdehyde dehydrogenase acvr1: activin-like kinase 2 (alk-2) acox3: encoding enzyme peroxisomal acyl-coenzyme a oxidase 3 afap1-as1: encoding protein afap1 antisense rna 1 aga: agu syndrome (finnish heritage disease) related gene agpat9: encoding enzyme glycerol-3-phosphate acyltransferase 3 a.k.a. 1-acylglycerol-3-phosphate o-acyltransferase 9 ank2: ankyrin 2, neuronal apbb2: encoding protein amyloid beta a4 precursor protein-binding family b member 2 art3: encoding enzyme ecto-adp-ribosyltransferase 3 asahl: encoding enzyme n-acylethanolamine-hydrolyzing acid amidase bank1: encoding protein b cell scaffold protein with ankyrin repeats 1 bend4: encoding protein ben domain containing 4 ccdc109b: coiled-coil domain containing 109b clnk: encoding protein cytokine dependent hematopoietic cell linker complement factor i: complement factor i col25a1-dt: encoding protein zinc finger, cchc domain containing 23 crmp1: collapsin response mediator protein 1, a member of crmp family csn2: beta-casein cxcl1: chemokine (c-x-c motif) ligand 1, scyb1 cxcl2: chemokine (c-x-c motif) ligand 2, scyb2 cxcl3: chemokine (c-x-c motif) ligand 3, scyb3 cxcl4: chemokine (c-x-c motif) ligand 4, platelet factor-4, pf-4, scyb4 cxcl5: chemokine (c-x-c motif) ligand 5, scyb5 cxcl6: chemokine (c-x-c motif) ligand 6, scyb6 cxcl7: chemokine (c-x-c motif) ligand 7, ppbp, scyb7 cxcl8: chemokine (c-x-c motif) ligand 8, interleukin 8 (il-8), scyb8 cxcl9: chemokine (c-x-c motif) ligand 9, scyb9 cxcl10: chemokine (c-x-c motif) ligand 10, scyb10 cxcl11: chemokine (c-x-c motif) ligand 11, scyb11 cxcl13: chemokine (c-x-c motif) ligand 13, scyb13 cytl1: cytokine-like 1 dcun1d4: defective in cullin neddylation 1 domain containing 4 dhx15: deah-box helicase 15 dkk2: dickkopf-related protein 2 dmac1: encoding protein transmembrane protein 261 dux4: thought to be inactive but 2010 research shows a key role in fshd elmod2: elmo domain-containing 2 emcn: endomucin evc: ellis–van creveld syndrome evc2: ellis–van creveld syndrome 2 (limbin) factor xi: mutations cause haemophilia c fam114a1: family with sequence similarity 114, member a1 fam149a: family with sequence similarity 149, member a fam193a: family with sequence similarity 193, member a fam198b: encoding protein protein ened fam221b: family with sequence similarity 221, member b fam47e-stbd1: fam47e-stbd1 readthrough fgf2: fibroblast growth factor 2 (basic fibroblast growth factor) fgfr3: fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism, bladder cancer) fgfrl1: fibroblast growth factor receptor-like 1 frg1: fshd region gene 1 fryl: encoding protein fry like transcription coactivator fstl5: encoding protein follistatin like 5 guf1: guf1 homolog, gtpase hdl3: encoding huntington-like neurodegenerative disorder 2 protein helq: encoding protein helicase, polq-like htt (huntingtin): huntingtin protein (huntington's disease) igj: linker protein for immunoglobulin alpha and mu polypeptides ints12: integrator complex subunit 12 kdr: kinase insert domain receptor (vascular endothelial growth factor receptor 2) kiaa1530: uv stimulated scaffold protein a lcorl: ligand dependent nuclear receptor corepressor like ldb2: lim domain-binding protein 2 lgi2: leucine-rich repeat lgi family member 2 loc100505912 encoding protein uncharacterized loc100505912 lsm6: u6 snrna-associated sm-like protein lto1p1: encoding protein oral cancer overexpressed 1 pseudogene 1 lyar: cell growth-regulating nucleolar protein mab21l2: mab-21-like 2 marcksl1: encoding protein marcks-like 1 maml3: mastermind-like 3 mfsd7: encoding protein major facilitator superfamily domain containing 7 mir1269a: microrna 1269a mir95: non-coding rna microrna 95 mlf1ip: centromere protein u mmaa: methylmalonic aciduria (cobalamin deficiency) cbla type mthfd2l: nad-dependent methylenetetrahydrofolate dehydrogenase 2-like protein myl5: myosin light chain 5 nap1l5: encoding protein nucleosome assembly protein 1 like 5 ndnf: encoding protein neuron derived neurotrophic factor noa1: encoding protein nitric oxide associated 1 npnt: encoding protein nephronectin nudt6: nudix hydrolase 6 nudt9: nudix hydrolase 9 otud4: otu domain-containing protein 4 pabpc4l: encoding protein poly(a) binding protein, cytoplasmic 4-like parm1: prostate androgen-regulated mucin-like protein 1 phox2b: codes for a homeodomain transcription factor pi4k2b: phosphatidylinositol 4-kinase type 2-beta pkd2: polycystic kidney disease 2 (autosomal dominant) plac8: encoding protein placenta specific 8 plk4: serine/threonine-protein kinase plk4 ppef2: encoding protein protein phosphatase with ef-hand domain 2 psapl1: encoding protein prosaposin-like 1 (gene/pseudogene) qdpr: quinoid dihydropteridine reductase rbm47: rna binding motif protein 47 rg9mtd2: encoding protein rna (guanine-9-) methyltransferase domain containing 2 scrg1: encoding protein stimulator of chondrogenesis 1 sdad1: protein sda1 homolog sec24b: sec24 homolog b sec24d: sec24 homolog d sept11: septin-11 slc9b2: solute carrier family 9 member b2 slc10a4: solute carrier family 10 member 4 smim20: encoding protein small integral membrane protein 20 snca: synuclein, alpha (non a4 component of amyloid precursor) spata5: spermatogenesis-associated protein 5 stath: gene with protein product tacc3: transforming acidic coiled-coil-containing protein 3 tenm3: teneurin transmembrane protein 3 thap6: thap domain-containing protein 6 tmem155: encoding protein transmembrane protein 155 tmem165: encoding protein transmembrane protein 165 tmem175: encoding protein transmembrane protein 175 tmem243: encoding protein transmembrane protein 243 tmprss11d: transmembrane protease, serine 11d tmprss11f: encoding protein transmembrane serine protease 11f tnip2: tnfaip3-interaction protein 2 tnip3: encoding protein tnfaip3 interacting protein 3 uchl1: ubiquitin carboxyl-terminal esterase l1 (ubiquitin thiolesterase) ugdh-as1: encoding protein ugdh antisense rna 1 ugt8: udp glycosyltransferase 8 unc5c: netrin receptor unc5c upf0602: encoding upf0602 protein c4orf47 usp38: encoding protein ubiquitin specific peptidase 38 usp53: ubiquitin specific peptidase 53 utp3: small subunit processome component wfs1: wolfram syndrome 1 (wolframin) zgrf1: zinc-finger grf-type containing 1 znf621: encoding protein zinc finger protein 621 diseases and disorders the following are some of the diseases related to genes located on chromosome 4: achondroplasia autosomal dominant polycystic kidney disease (pkd-2) bladder cancer crouzonodermoskeletal syndrome chronic lymphocytic leukemia congenital central hypoventilation syndrome ellis–van creveld syndrome facioscapulohumeral muscular dystrophy fibrodysplasia ossificans progressiva (fop) haemophilia c huntington's disease hemolytic uremic syndrome hereditary benign intraepithelial dyskeratosis hirschprung's disease hypochondroplasia methylmalonic acidemia mucopolysaccharidosis type i muenke syndrome nonsyndromic deafness nonsyndromic deafness, autosomal dominant parkinson's disease polycystic kidney disease romano–ward syndrome saddan tetrahydrobiopterin deficiency thanatophoric dysplasia type 1 type 2 wolfram syndrome wolf–hirschhorn syndrome cytogenetic band g-banding ideograms of human chromosome 4g-banding ideogram of human chromosome 4 in resolution 850 bphs. band length in this diagram is proportional to base-pair length. this type of ideogram is generally used in genome browsers (e.g. ensembl, ucsc genome browser).g-banding patterns of human chromosome 4 in three different resolutions (400, 550 and 850). band length in this diagram is based on the ideograms from iscn (2013). this type of ideogram represents actual relative band length observed under a microscope at the different moments during the mitotic process. g-bands of human chromosome 4 in resolution 850 bphs chr. arm band iscnstart iscnstop basepairstart basepairstop stain density 4p 16.3022014500000 gneg 4p 16.22203894,500,0016,000,000 gpos25 4p 16.13897796,000,00111,300,000 gneg 4p 15.33779106611,300,00115,000,000 gpos50 4p 15.321066128615,000,00117,700,000 gneg 4p 15.311286155717,700,00121,300,000 gpos75 4p 15.21557181121,300,00127,700,000 gneg 4p 15.11811216627,700,00135,800,000 gpos100 4p 142166250535,800,00141,200,000 gneg 4p 132505274241,200,00144,600,000 gpos50 4p 122742287744,600,00148,200,000 gneg 4p 112877304648,200,00150,000,000 acen 4q 113046324950,000,00151,800,000 acen 4q 123249357151,800,00158,500,000 gneg 4q 13.13571391058,500,00165,500,000 gpos100 4q 13.23910406265,500,00169,400,000 gneg 4q 13.34062433369,400,00175,300,000 gpos75 4q 21.14333450275,300,00178,000,000 gneg 4q 21.214502467178,000,00181,500,000 gpos50 4q 21.224671473981,500,00183,200,000 gneg 4q 21.234739487483,200,00186,000,000 gpos25 4q 21.34874514586,000,00187,100,000 gneg 4q 22.15145551787,100,00192,800,000 gpos75 4q 22.25517563692,800,00194,200,000 gneg 4q 22.35636589094,200,00197,900,000 gpos75 4q 235890605997,900,001100,100,000 gneg 4q 2460596347100,100,001106,700,000 gpos50 4q 2563476685106,700,001113,200,000 gneg 4q 2666857040113,200,001119,900,000 gpos75 4q 2770407277119,900,001122,800,000 gneg 4q 28.172777565122,800,001127,900,000 gpos50 4q 28.275657734127,900,001130,100,000 gneg 4q 28.377348259130,100,001138,500,000 gpos100 4q 31.182598581138,500,001140,600,000 gneg 4q 31.2185818733140,600,001145,900,000 gpos25 4q 31.2287338851145,900,001147,500,000 gneg 4q 31.2388519004147,500,001150,200,000 gpos25 4q 31.390049207150,200,001154,600,000 gneg 4q 32.192079545154,600,001160,800,000 gpos100 4q 32.295459681160,800,001163,600,000 gneg 4q 32.396819985163,600,001169,200,000 gpos100 4q 33998510087169,200,001171,000,000 gneg 4q 34.11008710341171,000,001175,400,000 gpos75 4q 34.21034110408175,400,001176,600,000 gneg 4q 34.31040810628176,600,001182,300,000 gpos100 4q 35.11062810967182,300,001186,200,000 gneg 4q 35.21096711170186,200,001190,214,555 gpos25