vemurafenib vemurafenib vemurafenib (inn), sold under the brand name zelboraf, is a medication used for the treatment of late-stage melanoma. it is an inhibitor of the b-raf enzyme and was developed by plexxikon. vemurafenibclinical datapronunciation/ˌvɛməˈræfənɪb/ vem-ə-raf-ə-nib trade nameszelborafother namesplx4032, rg7204, ro5185426ahfs/drugs.commonographmedlineplusa612009license data eu ema: by inn us fda: vemurafenib pregnancycategory au: d routes ofadministrationby mouthatc codel01xe15 (who) legal statuslegal status au: s4 (prescription only) ca: ℞-only uk: pom (prescription only) us: ℞-only identifiers iupac name n-(3--2,4-difluorophenyl)propane-1-sulfonamide cas number918504-65-1pubchem cid42611257iuphar/bps5893drugbankdb08881chemspider24747352 yunii207smy3fqtkeggd09996 ychemblchembl1229517pdb ligand032 (pdbe, rcsb pdb)comptox dashboard (epa)dtxsid50238710 echa infocard100.287.801 chemical and physical dataformulac23h18clf2n3o3smolar mass489.92 g·mol−13d model (jsmol)interactive image smiles cccs(=o)(=o)nc1ccc(f)c(c1f)c(=o)c2cc3c2cc(cn3)c4ccc(cl)cc4 inchi inchi=1s/c23h18clf2n3o3s/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29h,2,9h2,1h3,(h,27,28) ykey:gpxbxxgiaqbqni-uhfffaoysa-n y (verify) vemurafenibdrug mechanismcrystallographic structure of b-raf (rainbow colored, n-terminus = blue, c-terminus = red) complexed with vemurafenib (spheres, carbon = white, oxygen = red, nitrogen = blue, chlorine = green, fluorine = cyan, sulfur = yellow).therapeutic usemelanomabiological targetbrafmechanism of actionprotein kinase inhibitor