autoimmune progesterone dermatitis autoimmune progesterone dermatitis autoimmune progesterone dermatitis may appear as urticarial papules, deep gyrate lesions, papulovesicular lesions, an eczematous eruption, or as targetoid lesions.: 82 autoimmune progesterone dermatitis initially manifests with eye symptoms, e.g. burning, and progresses into rashes. its relapsing-remitting pattern in women correspond to the progesterone levels during the menstrual cycle, which spike twice a month. it is an extremely rare disease. autoimmune progesterone dermatitisspecialtydermatology