sorivudine sorivudine sorivudine (inn), is a nucleoside analogue antiviral drug, marketed under trade names such as usevir (nippon shoji, eisai) and brovavir (bms). it is used for the treatment of varicella zoster virus infections. sorivudineclinical datatrade namesusevir, brovavirother namesbv-arau, bromovinyl arau, 5-bromovinyl-arau, 5--1-pyrimidine-2,4-dioneroutes ofadministrationoralatc codenonepharmacokinetic datametabolismviral thymidine kinaseexcretionkidneyidentifiers iupac name 1-β-d-arabinofuranosyl-5-pyrimidine-2,4(1h,3h)-dione cas number77181-69-2 ypubchem cid5282192chemspider4445384 nuniic7voz162lvkeggd01734 ychemblchembl375035 ncomptox dashboard (epa)dtxsid6057827 chemical and physical dataformulac11h13brn2o6molar mass349.137 g·mol−13d model (jsmol)interactive image smiles c1c(c(=o)c(=o)n12(((o2)co)o)o)/c=c/br inchi inchi=1s/c11h13brn2o6/c12-2-1-5-3-14(11(19)13-9(5)18)10-8(17)7(16)6(4-15)20-10/h1-3,6-8,10,15-17h,4h2,(h,13,18,19)/b2-1+/t6-,7-,8+,10-/m1/s1 nkey:gcqyyihyqmvwlt-hqnltjapsa-n n ny (what is this?) (verify) pharmacology feature first-line treatment of herpes drug acyclovir was (zovirax, activir) from vzv strong activity of the virus. undergoes gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted in urine. mechanism of action sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's dna instead of the correct nucleoside. it is a competitive inhibitor of dna polymerase, so the viral dna cannot be replicated and the virus cannot grow. microbiology sorivudine is active against most species in the herpesvirus family. herpes simplex virus type i (hsv-1) varicella zoster virus (vzv) epstein–barr virus (ebv) interactions bromovinyluracil (bvu) sorivudine interacts strongly and in some cases lethally with fluorouracil (5-fu), its prodrugs and related substances. this is based on the metabolite bromovinyluracil (bvu), which irreversibly inhibits the enzyme dihydropyrimidine dehydrogenase (dpd) which is necessary for inactivating 5-fu. the closely related drug brivudine has the same interaction.