sivelestat sivelestat sivelestat (inn, research name ono 5046, marketed as elaspol) is an inhibitor of human neutrophil elastase. sivelestatclinical dataahfs/drugs.cominternational drug namesroutes ofadministrationivatc codenonelegal statuslegal status us: not approved in general: ℞ (prescription only) identifiers iupac name n-sulfonyl)amino]benzoyl}glycine cas number127373-66-4 npubchem cid107706iuphar/bps6441chemspider96875 yuniidwi62g0p59keggd03788 ychemblchembl76688 ycomptox dashboard (epa)dtxsid9048304 chemical and physical dataformulac20h22n2o7smolar mass434.46 g·mol−13d model (jsmol)interactive image smiles cc(c)(c)c(=o)oc1=cc=c(c=c1)s(=o)(=o)nc2=cc=cc=c2c(=o)ncc(=o)o inchi inchi=1s/c20h22n2o7s/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22h,12h2,1-3h3,(h,21,25)(h,23,24) ykey:btgngjjlzoiyid-uhfffaoysa-n y ny (what is this?) (verify) it is used in the treatment of acute respiratory failure and preliminary studies show it may also improve neuropathic pain. synthesis sivelestat is synthesised as follows: