bioinformatics resource centers bioinformatics resource centers the bioinformatics resource centers (brcs) are a group of five internet-based research centers established in 2004 and funded by niaid (the national institute of allergy and infectious diseases.) the brcs were formed in response to the threats posed by emerging and re-emerging pathogens, particularly centers for disease control and prevention (cdc) category a, b, and c pathogens, and their potential use in bioterrorism. the intention of niaid in funding these bioinformatics centers is to assist researchers involved in the experimental characterization of such pathogens and the formation of drugs, vaccines, or diagnostic tools to combat them. the main goals of the brcs are as follows: 1) to create comprehensive databases of reliable, up-to-date bioinformatic data (genetic, proteomic, biochemical, or microbiological) related to the pathogens of interest; 2) to provide researchers with easy access to this data through internet-based search and data retrieval user interfaces; 3) to provide researchers with relevant, state-of-the art computational tools for bioinformatic analysis of these data. the five brcs are supported by various institutions, both publicly and privately owned, throughout the usa and canada. each brc focuses on a different group of pathogens. bioinformatics resource centers name acrono name contributing organization(s) number of organisms covered organisms covered (cdc category) eukaryotic pathogen database resources eupathdb university of pennsylvania university of georgia 45 in 13 genera crithidia (other) cryptosporidium (b) encephalitozoon (group i) entamoeba (b) enterocytozoon (group i) giardia (b) leishmania (other) neospora (other) plasmodium (other) theileria (other) toxoplasma (b) trichomonas (other) trypanosoma (other) influenza research database ird j. craig venter institute university of chicago 1 influenza virus (flu) (c) pathosystems resource integration center patric virginia bioinformatics institute university of chicago national centre for text mining 22 genera bacillus (a) bartonella (group i) borrelia (group i) brucella (b) burkholderia (b) campylobacter (b) chlamydophila (b) clostridium (a) coxiella (b) ehrlichia (group i) escherichia (b) francisella (a) helicobacter (group i) listeria (b) mycobacterium (c) rickettsia (b, c) salmonella (b) shigella (b) staphylococcus (b) vibrio (b) yersinia (a, b) other bacteria virus pathogen database and analysis resource vipr j. craig venter institute university of chicago 13 families arenaviridae (a) bunyaviridae (a) filoviridae (a) flaviviridae (a) poxviridae (a) caliciviridae (b) togaviridae (b) hepatitis a virus (b) coronaviridae (c) paramyxoviridae (c) lyssavirus (c) hepatitis e herpesviridae reoviridae vectorbase vb university of notre dame european bioinformatics institute imperial college london 30 anopheles gambiae (other) anopheles species (x16) (other) aedes aegypti (other) biomphalaria glabrata (other) culex quinquefasciatus (other) glossina species (x5) (other) ixodes scapularis (other) lutzomyia longipalpis (other) musca domestica (other) pediculus humanus (other) phlebotomus papatasi (other) pathogen portal none virginia bioinformatics institute data for 13 species: gene expression, proteomics vaccinia (other) variola (a) monkeypox (a) coronavirus (c) brucella abortus (b) bacillus anthracis (a) salmonella typhimurium (b) yersinia pestis (a) vibrio cholerae (b) cryptosporidium parvum (b) toxoplasma gondii (b) homo sapiens (other) mus musculus (other)