n-desmethylenzalutamide n-desmethylenzalutamide n-desmethylenzalutamide is a nonsteroidal antiandrogen (nsaa) and the major metabolite of enzalutamide, an nsaa which is used as a hormonal antineoplastic agent in the treatment of metastatic prostate cancer. it has similar activity to that of enzalutamide and, with enzalutamide therapy, circulates at similar concentrations to those of enzalutamide at steady state. n-desmethylenzalutamide is formed from enzalutamide in the liver by the cytochrome p450 enzymes cyp2c8 and cyp3a4. it has a longer terminal half-life than enzalutamide (7.8 days versus 5.8 days). n-desmethylenzalutamideclinical dataother namesdesmethylenzalutamide; norenzalutamidedrug classnonsteroidal antiandrogenpharmacokinetic dataprotein binding95%elimination half-life7.8 daysidentifiers iupac name 4--5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluorobenzamide cas number1242137-16-1 ypubchem cid70678916chemspider28533218unii567tx6ub9schebichebi:68538chemical and physical dataformulac20h14f4n4o2smolar mass450.41 g·mol−13d model (jsmol)interactive image smiles cc1(c(=o)n(c(=s)n1c2=cc(=c(c=c2)c(=o)n)f)c3=cc(=c(c=c3)c#n)c(f)(f)f)c inchi inchi=1s/c20h14f4n4o2s/c1-19(2)17(30)27(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)28(19)12-5-6-13(16(26)29)15(21)8-12/h3-8h,1-2h3,(h2,26,29)key:jsfogzgibiqrpu-uhfffaoysa-n