pamidronic acid pamidronic acid pamidronic acid or pamidronate disodium or apd (marketed as aredia among others), is a nitrogen-containing bisphosphonate used to prevent osteoporosis. pamidronic acidclinical datatrade namesaredia, pamimed, among othersother namespamidronate disodium pentahydrate, pamidronate disodiumahfs/drugs.cominternational drug namesmedlineplusa601163pregnancycategory au: b3 routes ofadministrationintravenousatc codem05ba03 (who) legal statuslegal status uk: pom (prescription only) us: ℞-only pharmacokinetic databioavailabilityn/aprotein binding54%metabolismnilelimination half-life28 ± 7 hoursexcretionrenalidentifiers iupac name (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid) cas number40391-99-9 ypubchem cid4674iuphar/bps7259drugbankdb00282 ychemspider4512 yuniioyy3447omckeggd07281 ychemblchembl834 ycomptox dashboard (epa)dtxsid4023414 echa infocard100.049.897 chemical and physical dataformulac3h11no7p2molar mass235.069 g·mol−13d model (jsmol)interactive image smiles o=p(o)(o)c(o)(ccn)p(=o)(o)o inchi inchi=1s/c3h11no7p2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5h,1-2,4h2,(h2,6,7,8)(h2,9,10,11) ykey:wruugtrcqowxeg-uhfffaoysa-n y (verify) it was patented in 1971 and approved for medical use in 1987. medical uses it is used to prevent bone loss, and treat osteoporosis. it is also used to strengthen bone in paget's disease, to prevent bone loss due to steroid use, and in certain cancers with high propensity to bone, such as multiple myeloma. due to its ability to sequester calcium in bone, it is also used to treat high calcium levels. it is also used as an experimental treatment of the bone disorder osteogenesis imperfecta. it has been studied in the treatment of complex regional pain syndrome. administration intravenous, usually 90 mg monthly. 30 mg, 60 mg, 90 mg and for hospitals, 120 mg vials are available, mixed with mannitol. side effects common side effects include bone pain, low calcium levels, nausea, and dizziness. osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including pamidronate. pamidronate activates human γδ t cells in vitro and in vivo, which may lead to flu-like symptoms upon administration. pharmacology relative potency bisphosphonate relative potency etidronate 1 tiludronate 10 pamidronate 100 alendronate 100-500 ibandronate 500-1000 risedronate 1000 zoledronate 5000