zofenopril zofenopril zofenopril (inn) is a medication that protects the heart and helps reduce high blood pressure. it is an angiotensin-converting enzyme (ace) inhibitor. zofenoprilclinical datatrade nameszocardis (ru)ahfs/drugs.cominternational drug namesroutes ofadministrationoralatc codec09aa15 (who) identifiers iupac name (2s,4s)-1--4-phenylsulfanylpyrrolidine-2-carboxylic acid cas number81872-10-8 ypubchem cid92400iuphar/bps6462drugbankdb13166 nchemspider83422 nunii290zy759pikeggd08688 ychebichebi:78539 nchemblchembl331378 ncomptox dashboard (epa)dtxsid0046640 chemical and physical dataformulac22h23no4s2molar mass429.55 g·mol−13d model (jsmol)interactive image smiles o=c(n2(c(=o)o)c(sc1ccccc1)c2)(c)csc(=o)c3ccccc3 inchi inchi=1s/c22h23no4s2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19h,12-14h2,1h3,(h,25,26)/t15-,18+,19+/m1/s1 nkey:iaiduhcbnlfxef-mnefbygvsa-n n ny (what is this?) (verify) in small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects. zofenopril is a prodrug with zofenoprilat as the active metabolite. it was patented in 1978 and approved for medical use in 2000.