rti-112 rti-112 rti(-4229)-112 (2β-carbomethoxy-3β-(3-methyl-4-chlorophenyl)tropane) is a synthetic stimulant drug from the phenyltropane family. in contrast to rti-113, which is dat selective, rti-112 is a nonselective triple reuptake inhibitor. rti-112identifiers iupac name methyl (1r,2s,3s,5s)-3-(4-chloro-3-methylphenyl)-8-methyl-8-azabicyclooctane-2-carboxylate cas number143982-09-6 nhcl: 150653-92-2 npubchem cid9972515chemspider8148107 nchemblchembl1812745 ncomptox dashboard (epa)dtxsid50432655 chemical and physical dataformulac17h22clno2molar mass307.82 g·mol−13d model (jsmol)interactive image smiles cc1=c(c=cc(=c1)2c3cc(2c(=o)oc)n3c)cl inchi inchi=1s/c17h22clno2/c1-10-8-11(4-6-14(10)18)13-9-12-5-7-15(19(12)2)16(13)17(20)21-3/h4,6,8,12-13,15-16h,5,7,9h2,1-3h3/t12-,13+,15+,16-/m0/s1 nkey:vmitzemddzvhbz-xnisgkrosa-n n ny (what is this?) (verify) in vitro tests show a very similar serotonin transporter (sert)/dopamine transporter (dat)/norepinephrine transporter (net) selectivity to cocaine, although in vivo behaviour is different: "the nonselective monoamine transporter inhibitor rti-126 and the dat-selective inhibitors rti-150 and rti-336 both had a faster rate of onset (30 min) and a short duration of action (4h). in contrast, the nonselective monoamine transporter inhibitor rti-112 had a slower rate of onset (30–60 min) and a longer duration of action (10h). the dat-selective inhibitors rti-171 and rti-177 also had slower rates of onset (30–120 min), but rti-171 had a short duration of action (2.5 h) while rti-177 had a very long duration of action (20 h)." the efficacy of cocaine analogs to elicit self-administration is related to the rate at which they are administered. slower onset analogs are less likely to function as behavioral stimulants than analogs eliciting a faster rate of onset. nonselective analogs are less likely to function as "reinforcers" than reuptake inhibitors that have dat specificity. in order for a dopamine reuptake inhibitor (dri) such as cocaine to induce euphoria, pet scans on primates reveal that the dat occupancy needs to be >60%. rti-112 has equipotent in vitro affinity at the sert, net and dat, respectively. rti-112 was not reliably self-administered, in contrast to the dat selective reuptake inhibitors that were used in this study. in vivo at the ed50, rti-112 had no dat occupancy at all. at the ed50, almost all of the rti-112 occupied the sert at this dose. a significantly higher dose was required to get >70% dat occupancy in the case of rti-112; however, rti-112 was still able to suppress cocaine administration at the ed50, suggesting a serotonergic mechanism was responsible for this.