mapracorat mapracorat mapracorat (inn, code names bol-303242-x, zk-245186) is an anti-inflammatory drug belonging to the experimental class of selective glucocorticoid receptor agonists (segras). it is in clinical trials for the topical treatment of atopic dermatitis, inflammation following cataract surgery, and allergic conjunctivitis. preliminary investigation for the treatment of keratoconjunctivitis sicca has been conducted in cellular models. mapracoratclinical dataroutes ofadministrationtopical (ointment, eye drops)atc codenonelegal statuslegal status investigational identifiers iupac name (2r)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-methyl]pentan-2-ol cas number887375-26-0 ypubchem cid24795088chemspider25104194 nunii145v79ybvpkeggd10136 necha infocard100.217.969 chemical and physical dataformulac25h26f4n2o2molar mass462.489 g·mol−13d model (jsmol)interactive image smiles c14occc4cc(f)cc1c(c)(c)cc(o)(c(f)(f)f)cnc(cccc2n3)c2ccc3c inchi inchi=1s/c25h26f4n2o2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32h,9-10,13-14h2,1-3h3/t24-/m1/s1 nkey:vjgfoybqoipqfy-xmmpixpasa-n n ny (what is this?) (verify) clinical trials phase ii clinical trials with mapracorat started in summer 2009. one trial was a double blind dose finding study for an ointment against atopic dermatitis. it tested concentrations of 0.01%, 0.03% and 0.1% versus placebo over four weeks in around 64 patients. this trial was conducted by intendis, a part of bayer healthcare pharmaceuticals specialized on dermatology, and completed in september or october 2010. the other trial, also with a double blind design, evaluated an ophthalmic suspension for the treatment of inflammation following cataract surgery. various concentrations and dosing schemes were tested versus placebo in about 550 patients. the study was conducted by bausch & lomb and completed in september 2010. its successor study, a phase iii trial, started in november 2010 and completed in august 2011. as of january 2017 no study results are available.