oral microbiology oral microbiology oral microbiology is the study of the microorganisms (microbiota) of the oral cavity and their interactions between oral microorganisms or with the host. the environment present in the human mouth is suited to the growth of characteristic microorganisms found there. it provides a source of water and nutrients, as well as a moderate temperature. resident microbes of the mouth adhere to the teeth and gums to resist mechanical flushing from the mouth to stomach where acid-sensitive microbes are destroyed by hydrochloric acid.