salpingo-oophorectomy salpingo-oophorectomy in medicine, salpingo-oophorectomy is the removal of an ovary and its fallopian tube. this procedure is most frequently associated with prophylactic surgery in response to the discovery of a brca mutation, particularly those of the normally tumor suppressing brca1 gene (or, with a statistically lower negative impact, those of the tumour suppressing brca2 gene), which can increase the risk of a woman developing ovarian cancer to as high as 65% (as high as 25% for a mutated brca2 gene). salpingo-oophorectomyicd-9-cm65.4, 65.6