celiprolol celiprolol celiprolol is a medication in the class of beta blockers, used in the treatment of high blood pressure. it has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. it is also a weak α2 receptor antagonist. celiprololclinical dataahfs/drugs.cominternational drug namesatc codec07ab08 (who) pharmacokinetic databioavailability30-70%elimination half-life5 hoursidentifiers iupac name (rs)-n'--n,n-diethylurea cas number56980-93-9pubchem cid2663drugbankdb04846 ychemspider2563uniidrb57k47qckeggd07660chemblchembl27810comptox dashboard (epa)dtxsid3020259 echa infocard100.054.980 chemical and physical dataformulac20h33n3o4molar mass379.501 g·mol−13d model (jsmol)interactive imagechiralityracemic mixture smiles o=c(n(cc)cc)nc1ccc(occ(o)cnc(c)(c)c)c(c1)c(=o)c it was patented in 1973 and approved for medical use in 1982. medical use celiprolol is believed to provide clinical benefit for people with vascular ehlers–danlos syndrome by promoting normal collagen synthesis in the blood vessels, and by shifting the pressure load away from the vessels most prone to dissection and rupture. in 2019, a new drug application (nda) for celiprolol was denied by the u.s. food and drug administration (fda), instead calling for an “adequate and well-controlled” trial to determine whether celiprolol reduced the risk of clinical events in patients with veds. brand names brand names include cardem, selectol, celipres, celipro, celol, cordiax, dilanorm