mesulergine mesulergine mesulergine (inn) (developmental code name cu-32085) is a drug of the ergoline group which was never marketed. it acts on serotonin and dopamine receptors. specifically, it is an agonist of dopamine d2-like receptors and serotonin 5-ht6 receptors and an antagonist of serotonin 5-ht2a, 5-ht2b, 5-ht2c, and 5-ht7 receptors. it also has affinity for the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht1f, and 5-ht5a receptors. the compound had entered clinical trials for the treatment of parkinson's disease; however, further development was halted due to adverse histological abnormalities in rats. it was also investigated for the treatment of hyperprolactinemia (high prolactin levels). mesulergineclinical dataother namescu-32085identifiers iupac name n'-(1,6-dimethylergolin-8α-yl)-n,n-dimethylsulfamide cas number64795-35-3 npubchem cid68848iuphar/bps206mesulergine: 232chemspider62081 yuniisml95fk06ichebichebi:73378 nchemblchembl462903 ncomptox dashboard (epa)dtxsid3046324 chemical and physical dataformulac18h26n4o2smolar mass362.49 g·mol−13d model (jsmol)interactive image smiles o=s(=o)(n(c)c)n2c3c4cccc1c4c(cn1c)c3n(c2)c inchi inchi=1s/c18h26n4o2s/c1-20(2)25(23,24)19-13-9-15-14-6-5-7-16-18(14)12(10-21(16)3)8-17(15)22(4)11-13/h5-7,10,13,15,17,19h,8-9,11h2,1-4h3/t13-,15+,17+/m0/s1 ykey:jlvhtnznkoscnb-ysvlishtsa-n y ny (what is this?) (verify)