act-335827 act-335827 act-335827 is an orally available, selective orexin 1 receptor antagonist with anxiolytic effects in animals. unlike other orexin receptor antagonists, act-335827 lacks sedative effects and was found to have no impact on sleep architecture in mice. act-335827clinical dataroutes ofadministrationoraldrug classorexin 1 receptor antagonistidentifiers iupac name (r)-2-((s)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1h)-yl)-n-isopropyl-2-phenylacetamide pubchem cid54765113chemspider30774267chemblchembl2413367chemical and physical dataformulac31h38n2o5molar mass518.654 g·mol−13d model (jsmol)interactive image smiles coc1=cc(c(c2=c3)n(ccc2=cc(oc)=c3oc)(c(nc(c)c)=o)c4=cc=cc=c4)=cc=c1oc inchi inchi=1s/c31h38n2o5/c1-20(2)32-31(34)30(22-10-8-7-9-11-22)33-15-14-23-18-28(37-5)29(38-6)19-24(23)25(33)16-21-12-13-26(35-3)27(17-21)36-4/h7-13,17-20,25,30h,14-16h2,1-6h3,(h,32,34)/t25-,30+/m0/s1key:hxhobpvrrpctlg-setsbseesa-n