estropipate estropipate estropipate, also known as piperazine estrone sulfate and sold under the brand names harmogen, improvera, ogen, ortho-est, and sulestrex among others, is an estrogen medication which is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms. it is a salt of estrone sulfate and piperazine, and is transformed into estrone and estradiol in the body. it is taken by mouth. estropipateclinical datatrade namesharmogen, improvera, ogen, ortho-est, sulestrex, othersother namespiperazine estrone sulfate; estrone sulfate piperazine salt; pipestroneahfs/drugs.commonographroutes ofadministrationby mouthdrug classestrogen; estrogen esteratc codenoneidentifiers iupac name phenanthren-3-yl] hydrogen sulfate; piperazine cas number7280-37-7 ypubchem cid5284555drugbankdb04574 ychemspider4447610 yuniisvi38uy019keggd00948 ychebichebi:4873 ychemblchembl1200980 ycomptox dashboard (epa)dtxsid3023005 echa infocard100.027.906 chemical and physical dataformulac22h32n2o5smolar mass436.57 g·mol−13d model (jsmol)interactive image smiles o=s(=o)(o)oc1cc4c(cc1)3(2ccc(=o)2(c)cc3)cc4.n1ccncc1 inchi inchi=1s/c18h22o5s.c4h10n2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16h,2,4,6-9h2,1h3,(h,20,21,22);5-6h,1-4h2/t14-,15-,16+,18+;/m1./s1 ykey:hzeqbcvbilbtep-zfinnjdlsa-n y (verify) medical uses estropipate is used to: alleviate symptoms of menopause as menopausal hormone therapy treat some types of infertility treat some conditions leading to underdevelopment of female sexual characteristics treat vaginal atrophy treat some types of breast cancer (particularly in men and postmenopausal women) treat prostate cancer prevent osteoporosis estrogen dosages for menopausal hormone therapy route/formestrogenlowstandardhigh oralestradiol0.5–1 mg/day1–2 mg/day2–4 mg/day estradiol valerate0.5–1 mg/day1–2 mg/day2–4 mg/day estradiol acetate0.45–0.9 mg/day0.9–1.8 mg/day1.8–3.6 mg/day conjugated estrogens0.3–0.45 mg/day0.625 mg/day0.9–1.25 mg/day esterified estrogens0.3–0.45 mg/day0.625 mg/day0.9–1.25 mg/day estropipate0.75 mg/day1.5 mg/day3 mg/day estriol1–2 mg/day2–4 mg/day4–8 mg/day ethinylestradiola2.5–10 μg/day5–20 μg/day– nasal sprayestradiol150 μg/day300 μg/day600 μg/day transdermal patchestradiol25 μg/dayb50 μg/dayb100 μg/dayb transdermal gelestradiol0.5 mg/day1–1.5 mg/day2–3 mg/day vaginalestradiol25 μg/day–– estriol30 μg/day0.5 mg 2x/week0.5 mg/day im or sc injectionestradiol valerate––4 mg 1x/4 weeks estradiol cypionate1 mg 1x/3–4 weeks3 mg 1x/3–4 weeks5 mg 1x/3–4 weeks estradiol benzoate0.5 mg 1x/week1 mg 1x/week1.5 mg 1x/week sc implantestradiol25 mg 1x/6 months50 mg 1x/6 months100 mg 1x/6 months footnotes: a = no longer used or recommended, due to health concerns. b = as a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation. note: dosages are not necessarily equivalent. sources: see template. available forms estropipate is available in the form of 0.75, 1.5, 3, and 6 mg oral tablets. pharmacology pharmacodynamics