erythema multiforme erythema multiforme erythema multiforme (em) is a skin condition that appears with red patches evolving into target lesions, typically on both hands. not to be confused with erythema migrans, despite that both often involve target lesions (but from different causes). erythema multiforme (em)other nameserythema multiforme minorerythema multiforme minor of the hands (note the blanching centers of the lesion)specialtydermatology it is a type of erythema possibly mediated by deposition of immune complexes (mostly igm-bound complexes) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. it is an uncommon disorder, with peak incidence in the second and third decades of life. the disorder has various forms or presentations, which its name reflects (multiforme, "multiform", from multi- + formis). target lesions are a typical manifestation. two types, one mild to moderate and one severe, are recognized (erythema multiforme minor and erythema multiforme major). erythema multiforme was first described by von hebra in 1860. signs and symptoms the condition varies from a mild, self-limited rash (e. multiforme minor) to a severe, life-threatening form known as erythema multiforme major (or erythema multiforme majus) that also involves mucous membranes. consensus classification: erythema multiforme minor—typical targets or raised, edematous papules distributed acrally erythema multiforme major—typical targets or raised, edematous papules distributed acrally with involvement of one or more mucous membranes; epidermal detachment involves less than 10% of total body surface area stevens–johnson syndrome and toxic epidermal necrolysis used to be considered part of the erythema multiforme spectrum, but that is no longer the case. the mild form usually presents with mildly itchy (but itching can be very severe), pink-red blotches, symmetrically arranged and starting on the extremities. it often takes on the classical "target lesion" appearance, with a pink-red ring around a pale center. resolution within 7–10 days is the norm. individuals with persistent (chronic) erythema multiforme will often have a lesion form at an injury site, e.g. a minor scratch or abrasion, within a week. irritation or even pressure from clothing will cause the erythema sore to continue to expand along its margins for weeks or months, long after the original sore at the center heals. target lesion erythema multiforme target lesions on the leg erythema multiforme of tongue causes