michels syndrome michels syndrome michels syndrome is a syndrome characterised by intellectual disability, craniosynostosis, blepharophimosis, ptosis, epicanthus inversus, highly arched eyebrows, and hypertelorism. people with michels syndrome vary in other symptoms such as asymmetry of the skull, eyelid, and anterior chamber anomalies, cleft lip and palate, umbilical anomalies, and growth and cognitive development. michels syndromeother namesoculopalatoskeletal syndromethis condition is inherited in an autosomal recessive mannerspecialtymedical genetics