piretanide piretanide piretanide is a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups. studies of piretanide in rats and dogs in comparison with other high-ceiling diuretics such as furosemide and bumetanide found a more suitable dose/response rate (regression line) and a more favourable sodium/potassium excretion ratio. these findings led eventually to studies in man and finally to the introduction as a saluretic and antihypertensive medication in germany, france, italy and other countries. piretanideclinical datatrade namesarelix, eurelix, tauliz, othersahfs/drugs.cominternational drug namesroutes ofadministrationby mouthatc codec03ca03 (who) legal statuslegal status eu: rx-only in general: ℞ (prescription only) pharmacokinetic databioavailability~90%protein binding96%metabolismnot identifiedexcretionurine (60%), feces (40%)identifiers iupac name 3-(aminosulfonyl)-4-phenoxy-5-pyrrolidin-1-ylbenzoic acid cas number55837-27-9 ypubchem cid4849iuphar/bps4742drugbankdb02925 nchemspider4683 nuniidq6kk6gv93keggd01634 ycomptox dashboard (epa)dtxsid2023488 echa infocard100.054.394 chemical and physical dataformulac17h18n2o5smolar mass362.40 g·mol−13d model (jsmol)interactive image smiles ns(=o)(=o)c1c(oc2ccccc2)c(n3cccc3)cc(c1)c(=o)o inchi inchi=1s/c17h18n2o5s/c18-25(22,23)15-11-12(17(20)21)10-14(19-8-4-5-9-19)16(15)24-13-6-2-1-3-7-13/h1-3,6-7,10-11h,4-5,8-9h2,(h,20,21)(h2,18,22,23) nkey:ujewtudslqgtoa-uhfffaoysa-n n ny (what is this?) (verify) it was made in 1973, patented in 1974, and approved for medical use in 1981. brand names brand names include arelix, eurelix, tauliz.