middle frontal gyrus middle frontal gyrus the middle frontal gyrus makes up about one-third of the frontal lobe of the human brain. (a gyrus is one of the prominent "bumps" or "ridges" on the surface of the human brain.) not to be confused with medial frontal gyrus. middle frontal gyrusmiddle frontal gyrus of the human brain.coronal section through anterior cornua of lateral ventricles.detailspart offrontal lobearterymiddle cerebralidentifierslatingyrus frontalis mediusneuronames84neurolex idbirnlex_1451ta98a14.1.09.118ta25454fma61859anatomical terms of neuroanatomy the middle frontal gyrus, like the inferior frontal gyrus and the superior frontal gyrus, is more of a region in the frontal gyrus than a true gyrus. the borders of the middle frontal gyrus are the inferior frontal sulcus below; the superior frontal sulcus above; and the precentral sulcus behind. additional images position of middle frontal gyrus (shown in red). left cerebral hemisphere seen from above. lateral surface of left cerebral hemisphere. lateral surface of right cerebral hemisphere. middle frontal gyrus is noted by red arrows. cerebrum. lateral view.deep dissection. cerebrum. lateral view.deep dissection. cerebrum. lateral view.deep dissection. rostral middle frontal gyrus. caudal middle frontal gyrus. middle frontal gyrus highlighted in green on coronal t1 mri images middle frontal gyrus highlighted in green on sagittal t1 mri images middle frontal gyrus highlighted in green on transversal t1 mri images