hemihyperplasia–multiple lipomatosis syndrome hemihyperplasia–multiple lipomatosis syndrome hemihyperplasia–multiple lipomatosis syndrome is a cutaneous condition characterized by multiple lipomas in association with asymmetric (but non-progressive and non-distorting) overgrowth, cutaneous capillary malformations, and thickened plantar skin with prominent creases. hemihyperplasia–multiple lipomatosis syndromespecialtydermatology