aplasia cutis-myopia syndrome aplasia cutis-myopia syndrome aplasia cutis-myopia syndrome is a rare genetic disorder characterized by a combination of aplasia cutis congenita, high myopia, and dysfunction of the cone-rods. other findings include congenital nystagmus, atrophy of the iris and pigment epithelium, easily scarred skin and keratoconus. only 4 cases (from the united kingdom and israel, respectively) have been described in medical literature. transmission is either autosomal dominant or autosomal recessive. aplasia cutis-myopia syndromeother namesaplasia cutis congenita, high myopia, and cone-rod dysfunctionspecialtymedical genetics