r13 (drug) r13 (drug) r13 is a small-molecule flavonoid and orally active, potent, and selective agonist of the tropomyosin receptor kinase b (trkb) – the main signaling receptor for the neurotrophin brain-derived neurotrophic factor (bdnf) – which is under development for the potential treatment of alzheimer's disease. it is a structural modification and prodrug of tropoflavin (7,8-dhf) with improved potency and pharmacokinetics, namely oral bioavailability and duration. the compound is a replacement for the earlier tropoflavin prodrug r7 and has similar properties to it. it was developed because while r7 displayed a good drug profile in animal studies, it showed almost no conversion into tropoflavin in human liver microsomes. in contrast to r7, r13 is readily hydrolyzed into tropoflavin in human liver microsomes. r13clinical dataother names4-oxo-2-phenyl-4h-chromene-7,8-diyl bis(methylcarbamate)routes ofadministrationby mouthpharmacokinetic datametabolitestropoflavinidentifiers iupac name n-methylcarbamate cas number1609067-49-3 ypubchem cid90117609uniiogg19t0lu2chemical and physical dataformulac19h16n2o6molar mass368.345 g·mol−13d model (jsmol)interactive image smiles cnc(=o)oc1=c(c2=c(c=c1)c(=o)c=c(o2)c3=cc=cc=c3)oc(=o)nc inchi inchi=1s/c19h16n2o6/c1-20-18(23)26-14-9-8-12-13(22)10-15(11-6-4-3-5-7-11)25-16(12)17(14)27-19(24)21-2/h3-10h,1-2h3,(h,20,23)(h,21,24)key:nwwrhmsyztwubd-uhfffaoysa-n