epiboxidine epiboxidine epiboxidine is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. it was developed as a less toxic analogue of the potent frog-derived alkaloid epibatidine, which is around 200 times stronger than morphine as an analgesic but produces extremely dangerous toxic nicotinic side effects. epiboxidinelegal statuslegal status investigational identifiers iupac name (1r,4s,6s)-6-(3-methylisoxazol-5-yl)-7-azabicycloheptane cas number188895-96-7pubchem cid5747670chemspider4677635uniixi646l2arjcomptox dashboard (epa)dtxsid20172258 chemical and physical dataformulac10h14n2omolar mass178.235 g·mol−13d model (jsmol)interactive image smiles cc1=noc(=c1)2c3cc2n3 inchi inchi=1s/c10h14n2o/c1-6-4-10(13-12-6)8-5-7-2-3-9(8)11-7/h4,7-9,11h,2-3,5h2,1h3/t7-,8-,9+/m0/s1key:geefpqbpvbfcsd-xhnckoqmsa-n epiboxidine is around one-tenth as potent as epibatidine as an α4β2 agonist, but has around the same potency as an α3β4 agonist. it has only one-tenth of the analgesic power of epibatidine, but is also much less toxic. uses despite its decreased potency and toxicity compared to epibatidine, epiboxidine itself is still too toxic to be developed as a drug for use in humans. it is used in scientific research and as a parent compound to derive newer analogues which may be safer and have greater potential for clinical development.