antiandrogen antiandrogen antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (dht) from mediating their biological effects in the body. they act by blocking the androgen receptor (ar) and/or inhibiting or suppressing androgen production. they can be thought of as the functional opposites of ar agonists, for instance androgens and anabolic steroids (aas) like testosterone, dht, and nandrolone and selective androgen receptor modulators (sarms) like enobosarm. antiandrogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiprogestogens. antiandrogendrug classbicalutamide, a nonsteroidal antiandrogen and the most widely used androgen receptor antagonist in the treatment of prostate cancer.class identifierssynonymsandrogen antagonists; androgen blockers; testosterone blockersuse• men and boys: prostate cancer; benign prostatic hyperplasia; scalp hair loss; paraphilias; hypersexuality; sex offenders; precocious puberty; priapism• women and girls: acne; seborrhea; hidradenitis suppurativa; hirsutism; scalp hair loss; hyperandrogenism; transgender hormone therapyatc codel02bbbiological targetandrogen receptor; progesterone receptor; estrogen receptor; gnrh receptor; 5α-reductase; cyp17a1 (17α-hydroxylase/17,20-lyase); p450scc; otherschemical classsteroidal; nonsteroidal; peptide