quinupramine quinupramine quinupramine (brand names kevopril, kinupril, adeprim, quinuprine) is a tricyclic antidepressant (tca) used in europe for the treatment of depression. quinupramineclinical dataroutes ofadministrationoralatc coden06aa23 (who) legal statuslegal status in general: ℞ (prescription only) pharmacokinetic dataelimination half-life33 hoursidentifiers iupac name (±)-11-quinuclidin-3-yl-5,6-dihydrobenzobenzazepine cas number31721-17-2pubchem cid93154chemspider84098unii29o61hff4lkeggd07336echa infocard100.046.149 chemical and physical dataformulac21h24n2molar mass304.437 g·mol−1 pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and h1 receptor antagonist (antihistamine), moderate 5-ht2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor. it has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, or d2 receptor. clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline. it can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself.