tofenacin tofenacin tofenacin is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the united kingdom and italy in 1971 and 1981, respectively, by brocades-stheeman & pharmacia (now part of astellas pharma). it acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in parkinson's disease patients. tofenacinclinical datatrade nameselamol, tofacine, tofalinother namestofenacin hydrochloride (usan us)routes ofadministrationby mouthatc codenonelegal statuslegal status in general: ℞ (prescription only) identifiers iupac name n-methyl-2-ethanamine cas number15301-93-6 10488-36-5 (hcl)pubchem cid25315chemspider23647uniic4a112m10hecha infocard100.035.746 chemical and physical dataformulac17h21nomolar mass255.361 g·mol−13d model (jsmol)interactive image smiles o(ccnc)c(c1ccccc1)c2ccccc2c inchi inchi=1s/c17h21no/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15/h3-11,17-18h,12-13h2,1-2h3key:pnykgcpsfklfka-uhfffaoysa-n