nne1 nne1 nne1 (also known as nnei, mn-24 and am-6527) is an indole-based synthetic cannabinoid, representing a molecular hybrid of apica and jwh-018 that is an agonist for the cannabinoid receptors, with ki values of 60.09 nm at cb1 and 45.298 nm at cb2 and ec50 values of 9.481 nm at cb1 and 1.008 nm at cb2. it was invented by abbott and has a cb1 receptor pec50 of 8.9 with around 80x selectivity over the related cb2 receptor. it is suspected that metabolic hydrolysis of the amide group of nne1 may release 1-naphthylamine, a known carcinogen, given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound apinaca, and nne1 was banned in new zealand in 2012 as a temporary class drug to stop it being used as an ingredient in then-legal synthetic cannabis products. nne1 was subsequently found to be responsible for the death of a man in japan in 2014. nne1legal statuslegal status ca: schedule ii de: npsg (industrial and scientific use only) uk: class b identifiers iupac name n-1-naphthalenyl-1-pentyl-1h-indole-3-carboxamide cas number1338925-11-3pubchem cid54752945chemspider26613275unii7fvt9p642kcomptox dashboard (epa)dtxsid50716467 chemical and physical dataformulac24h24n2omolar mass356.469 g·mol−13d model (jsmol)interactive image smiles cccccn1cc(c2c1cccc2)c(=o)nc1cccc2c1cccc2 inchi inchi=1s/c24h24n2o/c1-2-3-8-16-26-17-21(20-13-6-7-15-23(20)26)24(27)25-22-14-9-11-18-10-4-5-12-19(18)22/h4-7,9-15,17h,2-3,8,16h2,1h3,(h,25,27)key:gwcqnkrmtgvyiz-uhfffaoysa-n