follicular fluid follicular fluid follicular fluid is a liquid which fills the follicular antrum and surrounds the ovum in an ovarian follicle. this fluid is rich in hyaluronic acid, and is used in a modified intracytoplasmic sperm injection (icsi) called physiological icsi (picsi), semi-viscous and yellow in colour. its components come mainly from granulosa cells. follicular fluidhuman ovum examined fresh in the liquor folliculidetailsidentifierslatinliquor folliculimeshd015571fma18665anatomical terminology