jwh-161 jwh-161 jwh-161 is a cannabinoid derivative that was designed by dr john w. huffman's team as a hybrid between the dibenzopyran "classical" cannabinoid drugs and the novel indole derivatives, in an attempt to unravel the differences in their binding modes to the cb1 receptor. while retaining structural elements from both families, jwh-161 has a cb1 ki of 19.0nm, although it was found to be slightly weaker than thc in animal tests. jwh-161identifiers iupac name (4ar,13br)-2,5,5-trimethyl-8-pentyl-3,4,4a,5,8,13b-hexahydroisochromenocarbazol-13-ol pubchem cid10431286chemspider8606713chemical and physical dataformulac27h33no2molar mass403.566 g·mol−13d model (jsmol)interactive image smiles oc3c5c1ccccc1n(c5cc2oc(4cc/c(=c\4c23)c)(c)c)ccccc inchi inchi=1s/c27h33no2/c1-5-6-9-14-28-21-11-8-7-10-18(21)24-22(28)16-23-25(26(24)29)19-15-17(2)12-13-20(19)27(3,4)30-23/h7-8,10-11,15-16,19-20,29h,5-6,9,12-14h2,1-4h3/t19-,20-/m1/s1key:vdjuafpnhzrtnl-wojbjxkfsa-n (verify)