fl3 (flavagline) fl3 (flavagline) fl3 is a synthetic flavagline that displays potent anticancer and cardioprotectant activities. this compound induces the death of cancer cells by an original mechanism that involves the apoptosis-inducing factor and caspase 12, suggesting that it may improve the efficacy of cancer chemotherapies. it was also shown that fl3 may enhance the efficacy of one of the most widely used anticancer agents, doxorubicin, and alleviate its main adverse effect, cardiac damage. fl3 names preferred iupac name (1r,3s,3ar,8bs)-3a-(4-bromophenyl)-6,8-dimethoxy-3-phenyl-1,2,3,3a-tetrahydro-8bh-cyclopentabenzofuran-1,8b-diol identifiers cas number 1186012-80-5 y 3d model (jsmol) interactive image chembl chembl556074 chemspider 24623199 pubchem cid 44233671 unii ftl3d4lre3 y inchi inchi=1s/c25h23bro5/c1-29-18-12-20(30-2)23-21(13-18)31-25(16-8-10-17(26)11-9-16)19(14-22(27)24(23,25)28)15-6-4-3-5-7-15/h3-13,19,22,27-28h,14h2,1-2h3/t19-,22+,24+,25-/m0/s1key: acixivsdwswvdw-mcwsdjlfsa-ninchi=1/c25h23bro5/c1-29-18-12-20(30-2)23-21(13-18)31-25(16-8-10-17(26)11-9-16)19(14-22(27)24(23,25)28)15-6-4-3-5-7-15/h3-13,19,22,27-28h,14h2,1-2h3/t19-,22+,24+,25-/m0/s1key: acixivsdwswvdw-mcwsdjlfbb smiles o12((c3=cc=cc=c3)c2o)(c4=cc=c(br)c=c4)oc5=cc(oc)=cc(oc)=c51 properties chemical formula c25h23bro5 molar mass 483.358 g·mol−1 except where otherwise noted, data are given for materials in their standard state (at 25 °c , 100 kpa). infobox references