potassium channel opener potassium channel opener a potassium channel opener is a type of drug which facilitates ion transmission through potassium channels. examples some examples include: diazoxide vasodilator used for hypertension, smooth muscle relaxing activity minoxidil vasodilator used for hypertension, also used to treat hair loss nicorandil vasodilator used to treat angina pinacidil retigabine, an anticonvulsant flupirtine, analgesic with muscle relaxant and anticonvulsant properties class subclasses activators calcium-activated 6t & 1p bk channel sk channel ik channel 1-ebio ns309 cyppa bkca-specific: flufenamic acid meclofenamic acid niflumic acid nimesulide rottlerin (mallotoxin) tolfenamic acid inwardly rectifying 2t & 1p romk (kir1.1) none gpcr regulated (kir3.x) gpcr agonists ml-297 (vu0456810) atp-sensitive (kir6.x) aprikalim bimakalim cromakalim diazoxide emakalim levcromakalim mazokalim minoxidil naminidil nicorandil pinacidil rilmakalim sarakalim tandem pore domain 4t & 2p twik (twik-1, twik-2, kcnk7) trek (trek-1, trek-2, traak) task (task-1, task-3, task-5) talk (task-2, talk-1, talk-2) thik (thik-1, thik-2) tresk halothane riluzole arachidonic acid voltage-gated 6t & 1p herg (kv11.1) kvlqt1 (kv7.1) kcnq (kv7)-specific: flupirtine retigabine (kv7)