true prevalence. newborn screening initiatives have found an unexpectedly high prevalence of the disease, as high as one in about 3,100 newborns in italy and have identified a surprisingly high frequency of newborn males around one in 1,500 in taiwan. research enzyme replacement therapy: replacement of the missing enzyme to clear the lipids (gl-3) from the cells substrate synthesis inhibition, also called substrate reduction therapy: inhibits the production of the lipid (gl-3) that accumulates in the cells chaperone therapy: uses small-molecule drugs that bind to the defective enzyme and stabilize it to increase enzyme activity and increase cellular function gene editing: technology that can potentially cut and fix a broken gene in a cell gene therapy: genetically modifies the affected cells to produce the missing enzyme. history fabry disease was first described by dermatologist johannes fabry and surgeon william anderson independently in 1898. it was recognised to be due to abnormal storage of lipids in 1952. in the 1960s, the inheritance pattern was established as being x-linked, as well as the molecular defect responsible for causing the accumulation of glycolipids. ken hashimoto published his classic paper on his electron microscopic findings in fabry disease in 1965. the first specific treatment for fabry disease was approved in 2001. society and culture house ("epic fail", season six, episode three) centers on a patient with fabry disease. scrubs ("my catalyst", season three, episode 12) features a fabry disease diagnosis. crossing jordan ("there's no place like home", season two, episode one) features a patient who died from fabry disease. the village (korean drama): "achiara's secret" features daughters of a serial rapist who find each other because they share fabry disease. doctor john (korean drama): in episode two, a prisoner is diagnosed with fabry disease. in lincoln rhyme: hunt for the bone collector, a copycat of the titular bone collector has fabry disease and takes galafold, which allows the detectives to learn his identity. partners for justice 2 (korean drama), features doctor k, who had fabry disease. doc (italian drama): series two features an episode with a tennis player who is diagnosed with fabry disease