cefalotin cefalotin cefalotin (inn) /ˌsɛfəˈloʊtɪn/ or cephalothin (usan) /ˌsɛfəˈloʊθɪn/ is a first-generation cephalosporin antibiotic. it was the first cephalosporin marketed (1964) and continues to be widely used. it is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. cefalotin sodium is marketed as keflin (lilly) and under other trade names. cefalotinclinical dataahfs/drugs.cominternational drug namesmedlineplusa682860pregnancycategory au: a routes ofadministrationintravenousatc codej01db03 (who) legal statuslegal status au: s4 (prescription only) uk: pom (prescription only) pharmacokinetic databioavailabilityn/aprotein binding65 to 80%metabolismhepaticelimination half-life30 minutes to 1 hourexcretionrenalidentifiers iupac name (6r,7r)-3--8-oxo-7--5-thia-1-azabicyclooct-2-ene-2-carboxylic acid cas number153-61-7 ypubchem cid6024drugbankdb00456 ychemspider5802 yuniir72lw146e6keggd07635 ychebichebi:124991 ychemblchembl617 ycomptox dashboard (epa)dtxsid4022783 echa infocard100.005.288 chemical and physical dataformulac16h16n2o6s2molar mass396.43 g·mol−13d model (jsmol)interactive imagemelting point160 to 160.5 °c (320.0 to 320.9 °f) smiles o=c2n1/c(=c(\cs12nc(=o)cc3sccc3)coc(=o)c)c(=o)o inchi inchi=1s/c16h16n2o6s2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15h,5-7h2,1h3,(h,17,20)(h,22,23)/t12-,15-/m1/s1 ykey:xiurvhnzvladcm-iuodeohrsa-n y (verify) the compound is a derivative of thiophene-2-acetic acid.