epimysium epimysium epimysium (plural epimysia) (greek epi- for on, upon, or above + greek mys for muscle) is the fibrous tissue envelope that surrounds skeletal muscle. it is a layer of dense irregular connective tissue which ensheaths the entire muscle and protects muscles from friction against other muscles and bones. it is continuous with fascia and other connective tissue wrappings of muscle including the endomysium and perimysium. it is also continuous with tendons, where it becomes thicker and collagenous. epimysiumstructure of a skeletal muscle (epimysium labeled at bottom center)detailslocationskeletal muscleidentifiersta98a04.0.00.041ta22009thh3.03.00.0.00006 fma9726anatomical terminology while the epimysium is irregular on muscles, it is regular on tendons.