carfenazine carfenazine carfenazine (inn) (former developmental code name wy-2445), or carphenazine (ban), also known as carphenazine maleate (usan) (brand name proketazine; former developmental code name nsc-71755), is an antipsychotic and tranquilizer of the phenothiazine group that was withdrawn from the market. carfenazineclinical dataother namesproketazine, carphenazinlicense data us fda: proketazine routes ofadministrationoralatc codenonelegal statuslegal status withdrawn identifiers iupac name 1-(10--10h-phenothiazin-2-yl)propan-1-one cas number2622-30-2pubchem cid18104iuphar/bps7140drugbankdb01038chemspider17100uniicly16y8z7echebichebi:51235chemblchembl1201328comptox dashboard (epa)dtxsid8022745 echa infocard100.018.249 chemical and physical dataformulac24h31n3o2smolar mass425.59 g·mol−13d model (jsmol)interactive image smiles ccc(=o)c1ccc2sc3ccccc3n(cccn4ccn(cco)cc4)c2c1 inchi inchi=1s/c24h31n3o2s/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28/h3-4,6-9,18,28h,2,5,10-17h2,1h3key:xzsmzrxaefnjcu-uhfffaoysa-n synthesis thieme synthesis: patent: the alkylation reaction between 2-propionyl phenothiazine (1) and 1-bromo-3-chloropropane (2) gives 1-propan-1-one (3). a second alkylation step, this time with 2-(1-piperazinyl)ethanol (4) completes the synthesis of carfenazine (5). nb: although above procedure is proof-of-concept, bear in mind no protecting group analogues butaperazine uses butanoyl (butyryl) and not propanoyl group. fluphenazine selfsame but trifluoromethyl on position 2 of the phenothiazine ring.