mandibuloacral dysplasia mandibuloacral dysplasia mandibuloacral dysplasia (mad) is a rare autosomal recessive syndrome characterized by mandibular hypoplasia, delayed cranial suture closure, dysplastic clavicles, abbreviated and club-shaped terminal phalanges, acroosteolysis, atrophy of the skin of the hands and feet, and typical facial changes.: 576 mandibuloacral dysplasiaother namesmad types type omim gene locus mada 248370 lmna 1q21.2 madb 608612 zmpste24 1p34