6-methyl-mda 6-methyl-mda 6-methyl-3,4-methylenedioxyamphetamine (6-methyl-mda) is an entactogen and psychedelic drug of the amphetamine class. it was first synthesized in the late 1990s by a team including david e. nichols at purdue university while investigating derivatives of 3,4-methylenedioxyamphetamine (mda) and 3,4-methylenedioxy-n-methylamphetamine (mdma). 6-methyl-mdaclinical dataroutes ofadministrationoralatc codenonelegal statuslegal status uncontrolled (but may be covered under the federal analogue act in the united states and under similar laws in other countries) identifiers iupac name 1-(6-methyl-1,3-benzodioxol-5-yl)propan-2-amine cas number246861-21-2pubchem cid10511982chemspider8687383 ychemblchembl6376 ychemical and physical dataformulac11h15no2molar mass193.246 g·mol−13d model (jsmol)interactive image smiles o1c2cc(c(cc2oc1)cc(n)c)c inchi inchi=1s/c11h15no2/c1-7-3-10-11(14-6-13-10)5-9(7)4-8(2)12/h3,5,8h,4,6,12h2,1-2h3 ykey:hcfhwxdizoautq-uhfffaoysa-n y (verify) 6-methyl-mda has ic50 values of 783 nm, 28,300 nm, and 4,602 nm for inhibiting the reuptake of serotonin, dopamine, and norepinephrine in rat synaptosomes. in animal studies it substitutes for mbdb, mmai, lsd, and 2,5-dimethoxy-4-iodoamphetamine (doi), though not amphetamine, but only partially and at high doses. thus, while several-fold less potent than its analogues 2-methyl-mda and 5-methyl-mda, and approximately half as potent as mda, 6-methyl-mda is still significantly active, and appropriate doses may be similar to or somewhat higher than those of mdma.