spiroxasone spiroxasone spiroxasone (inn, usan) is a synthetic, steroidal antimineralocorticoid of the spirolactone group which was developed as a diuretic and antihypertensive agent but was never marketed. it was synthesized and assayed in 1963. the drug is 7α-acetylthiospirolactone with the ketone group removed from the c17α spirolactone ring. similarly to other spirolactones like spironolactone, spiroxasone also possesses antiandrogen activity. spiroxasoneclinical dataroutes ofadministrationby mouthidentifiers iupac name s-phenanthrene-17,2'-oxolane]-7-yl] ethanethioate cas number6673-97-8pubchem cid23141chemspider21652unii8p0u2za1nqkeggd05912chemblchembl2105514chemical and physical dataformulac24h34o3smolar mass402.59 g·mol−13d model (jsmol)interactive image smiles cc(=o)s1cc2=cc(=o)cc2(314cc5(4(cc3)c)ccco5)c inchi inchi=1s/c24h34o3s/c1-15(25)28-20-14-16-13-17(26)5-9-22(16,2)18-6-10-23(3)19(21(18)20)7-11-24(23)8-4-12-27-24/h13,18-21h,4-12,14h2,1-3h3/t18-,19-,20+,21+,22-,23-,24-/m0/s1key:xkcgicbtwrnucl-kieakmpysa-n