t-cell vaccination t-cell vaccination t-cell vaccination is immunization with inactivated autoreactive t cells. the concept of t-cell vaccination is, at least partially, analogous to classical vaccination against infectious disease. however, the agents to be eliminated or neutralized are not foreign microbial agents but a pathogenic autoreactive t-cell population. research on t-cell vaccination so far has focused mostly on multiple sclerosis and to a lesser extent on rheumatoid arthritis, crohn's disease and aids. for vaccines designed to induce protective t cells, see t-cell vaccine.