11-hydroxy-thc 11-hydroxy-thc 11-hydroxy-δ9-tetrahydrocannabinol (11-oh-δ9-thc, alternatively numbered as 7-oh-δ1-thc), usually referred to as 11-hydroxy-thc is the main active metabolite of tetrahydrocannabinol (thc), which is formed in the body after δ9-thc is consumed. for the isomer of this chemical inherited from δ8-tetrahydrocannabinol, see 11-hydroxy-delta-8-thc. 11-hydroxy-thcclinical datadrug classcannabinoidlegal statuslegal status uk: class b identifiers iupac name (6ar,10ar)-9-(hydroxymethyl)-6,6-dimethyl-3-pentyl- 6a,7,8,10a-tetrahydro-6h-benzochromen-1-ol cas number36557-05-8 npubchem cid37482chemspider34385 yunii9vy04n5slbcomptox dashboard (epa)dtxsid50190061 echa infocard100.164.583 chemical and physical dataformulac21h30o3molar mass330.468 g·mol−13d model (jsmol)interactive image smiles oc2cc(cc1oc(c3cc/c(=c\c3c12)co)(c)c)ccccc inchi inchi=1s/c21h30o3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h10-12,16-17,22-23h,4-9,13h2,1-3h3 ykey:ycbkssaweudacy-uhfffaoysa-n y ny (what is this?) (verify) after cannabis consumption, thc is metabolized inside the body by cytochrome p450 enzymes such as cyp2c9 and cyp3a4 into 11-hydroxy-thc and then further metabolized by the dehydrogenase and cyp2c9 enzyme to form 11-nor-9-carboxy-thc (thc-cooh) which is inactive at the cb1 receptors; and further glucuronidated to form 11-nor-δ9-tetrahydrocannabinol-9-carboxylic acid glucuronide (δ9-thc-cooh-glu) where it is excreted in both feces and urine. both compounds, along with thc, can be assayed in drug tests. 11-hydroxy-thc can be formed after consumption of thc from inhalation (vaping, smoking) and oral (by mouth, edible, sublingual) use, although levels of 11-hydroxy-thc are typically higher when eaten compared to inhalation. pharmacology like δ9-thc, 11-hydroxy-thc is a partial agonist at the cannabinoid receptor cb1 with significantly higher binding affinity (ki = 0.37 nm compared to δ9-thc ki = 35 nm). with respect to camp inhibition at cb1 it displays a similar efficacy to that of δ9-thc (ec50 = 11 nm vs. ec50 = 5.2 nm, respectively), but a lower maximum response (emax = 28% vs. emax = 70%). research in an analysis by the university of rhode island on cannabinoids it was found that 11-oh-δ9-thc had the 3rd highest 3c-like protease inhibitor activity against covid-19 out of all the cannabinoids tested within that study but not as high as the antiviral drug gc376 (56% 11-oh-δ9-thc) vs 100% gc376).