AdultPediatricDosage Forms & Strengths metered-dose inhaler (dry powder) 400mcg/actuation Chronic Obstructive Pulmonary Disease Breath-activated dry powder inhaler indicated for maintenance treatment of chronic obstructive pulmonary disease (COPD) 400 mcg (1 actuation) inhaled PO BID Dosage Modifications Renal impairment: No dosage adjustment required Hepatic impairment: Not studiedSafety and efficacy not establishedInteraction CheckerEnter a drug name and aclidiniumNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (1)umeclidinium bromide/vilanterol inhaledaclidinium, umeclidinium bromide/vilanterol inhaled. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated. Duplicate therapy.Serious - Use Alternative (4)glucagonglucagon increases toxicity of aclidinium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .glucagon intranasalglucagon intranasal increases toxicity of aclidinium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .pramlintidepramlintide, aclidinium. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.revefenacinrevefenacin and aclidinium both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.Monitor Closely (97)abobotulinumtoxinAabobotulinumtoxinA increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .amantadineaclidinium, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amitriptylineaclidinium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapineaclidinium and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.aripiprazoleaclidinium decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.aripiprazole increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atracuriumatracurium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineatropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMatropine IV/IM and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna alkaloidsbelladonna alkaloids and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumbelladonna and opium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.benperidolaclidinium decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.benperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benztropinebenztropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.bethanecholbethanechol increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbacholcarbachol increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.cevimelinecevimeline increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazineaclidinium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cisatracuriumcisatracurium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.clomipramineaclidinium and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.clozapineaclidinium decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.clozapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cyclizinecyclizine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.darifenacindarifenacin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.desipramineaclidinium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.dicyclominedicyclomine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenhydraminediphenhydramine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.donepezildonepezil increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil transdermaldonepezil transdermal, aclidinium. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.dosulepinaclidinium and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepinaclidinium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.droperidolaclidinium decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.droperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.echothiophate iodideechothiophate iodide increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.fesoterodinefesoterodine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.flavoxateflavoxate and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.fluphenazineaclidinium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.galantaminegalantamine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.glycopyrrolateglycopyrrolate and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrrolate inhaledglycopyrrolate inhaled and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrronium tosylate topicalglycopyrronium tosylate topical, aclidinium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.haloperidolaclidinium decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.haloperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.henbanehenbane and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.homatropinehomatropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine Ahuperzine A increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hyoscyaminehyoscyamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.hyoscyamine sprayhyoscyamine spray and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.iloperidoneaclidinium decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor.iloperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.imipramineaclidinium and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.ipratropiumipratropium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.levodopaaclidinium, levodopa. Other (see comment). Use Caution/Monitor. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .lofepramineaclidinium and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.loxapineaclidinium decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.aclidinium decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor.loxapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.loxapine inhaledloxapine inhaled increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.aclidinium decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor.maprotilineaclidinium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.meclizinemeclizine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.methscopolaminemethscopolamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.neostigmineneostigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineaclidinium and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.olanzapineaclidinium decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.aclidinium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.olanzapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.oliceridineaclidinium increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.onabotulinumtoxinAonabotulinumtoxinA and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrineaclidinium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutyninoxybutynin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin topicaloxybutynin topical and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin transdermaloxybutynin transdermal and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.paliperidoneaclidinium decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.paliperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pancuroniumpancuronium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.perphenazineaclidinium decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.perphenazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.physostigminephysostigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pilocarpinepilocarpine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozideaclidinium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pralidoximepralidoxime and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.prochlorperazineaclidinium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.promethazineaclidinium decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.promethazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.propanthelinepropantheline and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.protriptylineaclidinium and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.pyridostigminepyridostigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.quetiapineaclidinium decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.quetiapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.rapacuroniumrapacuronium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.rimantadineaclidinium, rimantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Enhanced CNS side effects.risperidoneaclidinium decreases levels of risperidone by pharmacodynamic antagonism. Use Caution/Monitor.risperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.rivastigminerivastigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.rocuroniumrocuronium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.scopolaminescopolamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.solifenacinsolifenacin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.succinylcholinesuccinylcholine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineaclidinium decreases levels of thioridazine by pharmacodynamic antagonism. Use Caution/Monitor.thioridazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.thiothixeneaclidinium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.thiothixene increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.tolterodineaclidinium and tolterodine both decrease cholinergic effects/transmission. Use Caution/Monitor.trazodoneaclidinium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.trifluoperazineaclidinium decreases levels of trifluoperazine by pharmacodynamic antagonism. Use Caution/Monitor.trifluoperazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.trihexyphenidylaclidinium and trihexyphenidyl both decrease cholinergic effects/transmission. Use Caution/Monitor.trimipramineaclidinium and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.trospium chlorideaclidinium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.umeclidinium bromideumeclidinium bromide and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor. If possible, avoid coadministration of additional anticholinergic agentsvecuroniumaclidinium and vecuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.ziprasidoneaclidinium decreases levels of ziprasidone by pharmacodynamic antagonism. Use Caution/Monitor.ziprasidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.zotepineaclidinium decreases levels of zotepine by pharmacodynamic antagonism. Use Caution/Monitor.Minor (4)dimenhydrinatedimenhydrinate increases toxicity of aclidinium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.donepezildonepezil decreases effects of aclidinium by pharmacodynamic antagonism. Minor/Significance Unknown.galantaminegalantamine decreases effects of aclidinium by pharmacodynamic antagonism. Minor/Significance Unknown.rimantadinerimantadine increases effects of aclidinium by pharmacodynamic synergism. Minor/Significance Unknown.abobotulinumtoxinAMonitor Closely (1)abobotulinumtoxinA increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .amantadineMonitor Closely (1)aclidinium, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amitriptylineMonitor Closely (1)aclidinium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapineMonitor Closely (1)aclidinium and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.anticholinergic/sedative combosMonitor Closely (1)anticholinergic/sedative combos and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.aripiprazoleMonitor Closely (2)aclidinium decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor. aripiprazole increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atracuriumMonitor Closely (1)atracurium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineMonitor Closely (1)atropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMMonitor Closely (1)atropine IV/IM and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna alkaloidsMonitor Closely (1)belladonna alkaloids and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)belladonna and opium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.benperidolMonitor Closely (2)aclidinium decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor. benperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benztropineMonitor Closely (1)benztropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.bethanecholMonitor Closely (1)bethanechol increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbacholMonitor Closely (1)carbachol increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.cevimelineMonitor Closely (1)cevimeline increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazineMonitor Closely (2)aclidinium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor. chlorpromazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cisatracuriumMonitor Closely (1)cisatracurium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.clomipramineMonitor Closely (1)aclidinium and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.clozapineMonitor Closely (2)aclidinium decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor. clozapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cyclizineMonitor Closely (1)cyclizine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)cyclobenzaprine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.darifenacinMonitor Closely (1)darifenacin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.desipramineMonitor Closely (1)aclidinium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.dicyclomineMonitor Closely (1)dicyclomine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.dimenhydrinateMinor (1)dimenhydrinate increases toxicity of aclidinium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.diphenhydramineMonitor Closely (1)diphenhydramine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.donepezilMonitor Closely (1)donepezil increases and