both increase sedation. Use Caution/Monitor.ziprasidonethiothixene and ziprasidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.thiothixene and ziprasidone both increase sedation. Use Caution/Monitor.zolmitriptanzolmitriptan, thiothixene. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).zotepinethiothixene and zotepine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.thiothixene and zotepine both increase sedation. Use Caution/Monitor.Minor (9)azithromycinazithromycin increases toxicity of thiothixene by QTc interval. Minor/Significance Unknown.brimonidinebrimonidine increases effects of thiothixene by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.chasteberrychasteberry decreases effects of thiothixene by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).chloroquinechloroquine increases toxicity of thiothixene by QTc interval. Minor/Significance Unknown.epinephrinethiothixene decreases effects of epinephrine by pharmacodynamic antagonism. Minor/Significance Unknown.epinephrine racemicthiothixene decreases effects of epinephrine racemic by pharmacodynamic antagonism. Minor/Significance Unknown.ethanolethanol, thiothixene. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.eucalyptusthiothixene and eucalyptus both increase sedation. Minor/Significance Unknown.sagethiothixene and sage both increase sedation. Minor/Significance Unknown.abametapirSerious - Use Alternative (1)abametapir will increase the level or effect of thiothixene by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP1A2 substrates. If not feasible, avoid use of abametapir.abobotulinumtoxinAMonitor Closely (1)abobotulinumtoxinA increases effects of thiothixene by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects.aclidiniumMonitor Closely (2)aclidinium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.acrivastineMonitor Closely (1)acrivastine and thiothixene both increase sedation. Use Caution/Monitor.adagrasibSerious - Use Alternative (1)adagrasib, thiothixene. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolMonitor Closely (1)thiothixene increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil and thiothixene both increase sedation. Use Caution/Monitor.almotriptanMonitor Closely (1)almotriptan, thiothixene. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).alprazolamMonitor Closely (1)alprazolam and thiothixene both increase sedation. Use Caution/Monitor.amifampridineMonitor Closely (1)thiothixene increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.amisulprideContraindicated (1)amisulpride, thiothixene. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndrome.amitriptylineMonitor Closely (1)thiothixene and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and thiothixene both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (2)thiothixene and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. thiothixene and amoxapine both increase sedation. Use Caution/Monitor.anticholinergic/sedative combosMonitor Closely (3)anticholinergic/sedative combos decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. anticholinergic/sedative combos decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.apomorphineMonitor Closely (1)thiothixene and apomorphine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)thiothixene decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.arformoterolMonitor Closely (1)thiothixene increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (2)aripiprazole and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. aripiprazole and thiothixene both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)aripiprazole and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.armodafinilMonitor Closely (1)thiothixene increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and thiothixene both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalMonitor Closely (1)asenapine transdermal and thiothixene both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.atracuriumMonitor Closely (3)atracurium decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. atracurium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of atracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropineMonitor Closely (3)atropine decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. atropine decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of atropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IMMonitor Closely (3)thiothixene increases effects of atropine IV/IM by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. atropine IV/IM decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. atropine IV/IM decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.avapritinibMonitor Closely (1)avapritinib and thiothixene both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and thiothixene both increase sedation. Use Caution/Monitor.azithromycinMinor (1)azithromycin increases toxicity of thiothixene by QTc interval. Minor/Significance Unknown.baclofenMonitor Closely (1)baclofen and thiothixene both increase sedation. Use Caution/Monitor.bedaquilineMonitor Closely (1)thiothixene and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsMonitor Closely (3)belladonna alkaloids decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. belladonna alkaloids decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of belladonna alkaloids by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.belladonna and opiumMonitor Closely (4)belladonna and opium decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. belladonna and opium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of belladonna and opium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. belladonna and opium and thiothixene both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (2)benperidol and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. benperidol and thiothixene both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenMonitor Closely (1)benzhydrocodone/acetaminophen and thiothixene both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)benzhydrocodone/acetaminophen, thiothixene. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzphetamineMonitor Closely (1)thiothixene increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benztropineMonitor Closely (1)thiothixene increases effects of benztropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. .brexanoloneMonitor Closely (1)brexanolone, thiothixene. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and thiothixene both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and thiothixene both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of thiothixene by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and thiothixene both increase sedation. Use Caution/Monitor.bromocriptineSerious - Use Alternative (1)thiothixene decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.brompheniramineMonitor Closely (1)brompheniramine and thiothixene both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)buprenorphine and thiothixene both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)buprenorphine buccal and thiothixene both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)buprenorphine subdermal implant and thiothixene both increase sedation. Use Caution/Monitor.buprenorphine transdermalMonitor Closely (1)buprenorphine transdermal and thiothixene both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionMonitor Closely (2)thiothixene increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. buprenorphine, long-acting injection and thiothixene both increase sedation. Use Caution/Monitor.butabarbitalMonitor Closely (1)butabarbital and thiothixene both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and thiothixene both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol and thiothixene both increase sedation. Use Caution/Monitor.cabergolineSerious - Use Alternative (1)thiothixene decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.caffeineMonitor Closely (1)thiothixene increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)thiothixene, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.cannabidiolMonitor Closely (1)cannabidiol, thiothixene. affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Owing to the potential for both CYP1A2 induction and inhibition with the coadministration of CYP1A2 substrates and cannabidiol, consider reducing dosage adjustment of CYP1A2 substrates as clinically appropriate.carbinoxamineMonitor Closely (1)carbinoxamine and thiothixene both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)carisoprodol and thiothixene both increase sedation. Use Caution/Monitor.carvedilolSerious - Use Alternative (1)carvedilol, thiothixene. Either increases levels of the other by decreasing metabolism. Contraindicated. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact).cenobamateMonitor Closely (1)cenobamate, thiothixene. Either increases effects of the other by sedation. Use Caution/Monitor.chasteberryMinor (1)chasteberry decreases effects of thiothixene by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).chloral hydrateMonitor Closely (1)chloral hydrate and thiothixene both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and thiothixene both increase sedation. Use Caution/Monitor.chloroquineMinor (1)chloroquine increases toxicity of thiothixene by QTc interval. Minor/Significance Unknown.chlorpheniramineMonitor Closely (1)chlorpheniramine and thiothixene both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (2)chlorpromazine and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and thiothixene both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)chlorzoxazone and thiothixene both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and thiothixene both increase sedation. Use Caution/Monitor.cisatracuriumMonitor Closely (3)cisatracurium decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. cisatracurium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of cisatracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.citalopramMonitor Closely (1)thiothixene and citalopram both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.clemastineMonitor Closely (1)clemastine and thiothixene both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)thiothixene, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)thiothixene and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and thiothixene both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, thiothixene. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Additive hypotensive effects; potential delirium.clorazepateMonitor Closely (1)clorazepate and thiothixene both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (2)clozapine and thiothixene both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. clozapine and thiothixene both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)clozapine and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.codeineMonitor Closely (1)codeine and thiothixene both increase sedation. Use Caution/Monitor.crizotinibMonitor Closely (1)crizotinib and thiothixene both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.cyclizineMonitor Closely (4)cyclizine decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. cyclizine decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. cyclizine and thiothixene both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (4)cyclobenzaprine decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. cyclobenzaprine decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor. thiothixene increases effects of cyclobenzaprine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. cyclobenzaprine and thiothixene both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and thiothixene both