both increase QTc interval. Modify Therapy/Monitor Closely.donepezilMonitor Closely (2)donepezil increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. donepezil and formoterol both increase QTc interval. Use Caution/Monitor.Minor (1)donepezil decreases effects of aclidinium by pharmacodynamic antagonism. Minor/Significance Unknown.donepezil transdermalMonitor Closely (1)donepezil transdermal, aclidinium. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.dopamineMonitor Closely (2)formoterol and dopamine both decrease sedation. Use Caution/Monitor. formoterol and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexamineMonitor Closely (4)dopexamine, formoterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. dopexamine and formoterol both decrease serum potassium. Use Caution/Monitor. dopexamine and formoterol both decrease sedation. Use Caution/Monitor. dopexamine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dosulepinMonitor Closely (1)aclidinium and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepinMonitor Closely (2)aclidinium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and formoterol both increase QTc interval. Avoid or Use Alternate Drug. doxepin, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dronedaroneSerious - Use Alternative (1)dronedarone and formoterol both increase QTc interval. Avoid or Use Alternate Drug.droperidolMonitor Closely (3)aclidinium decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor. droperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. droperidol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)droperidol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.drospirenoneMonitor Closely (1)drospirenone increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.echothiophate iodideMonitor Closely (1)echothiophate iodide increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.efavirenzMonitor Closely (1)efavirenz and formoterol both increase QTc interval. Use Caution/Monitor.encorafenibMonitor Closely (1)encorafenib and formoterol both increase QTc interval. Use Caution/Monitor.entrectinibSerious - Use Alternative (1)formoterol and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.ephedrineMonitor Closely (3)ephedrine and formoterol both decrease serum potassium. Use Caution/Monitor. ephedrine and formoterol both decrease sedation. Use Caution/Monitor. ephedrine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrineMonitor Closely (3)epinephrine and formoterol both decrease serum potassium. Use Caution/Monitor. epinephrine and formoterol both decrease sedation. Use Caution/Monitor. epinephrine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicMonitor Closely (3)formoterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. formoterol and epinephrine racemic both decrease sedation. Use Caution/Monitor. formoterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine racemic and formoterol both increase QTc interval. Avoid or Use Alternate Drug.eribulinMonitor Closely (1)eribulin and formoterol both increase QTc interval. Use Caution/Monitor.erythromycin baseSerious - Use Alternative (1)erythromycin base and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)erythromycin ethylsuccinate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)erythromycin lactobionate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)erythromycin stearate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.escitalopramMonitor Closely (1)escitalopram increases toxicity of formoterol by QTc interval. Use Caution/Monitor.esmololMonitor Closely (2)esmolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. esmolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethacrynic acidMonitor Closely (1)formoterol and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.ethanolMonitor Closely (1)ethanol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.etodolacMonitor Closely (1)etodolac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.eucalyptusMinor (1)eucalyptus increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.fenfluramineMonitor Closely (2)formoterol and fenfluramine both decrease sedation. Use Caution/Monitor. formoterol and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.fenoprofenMonitor Closely (1)fenoprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fesoterodineMonitor Closely (1)fesoterodine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.fexinidazoleSerious - Use Alternative (1)fexinidazole and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fingolimodMonitor Closely (1)fingolimod and formoterol both increase QTc interval. Use Caution/Monitor.flavoxateMonitor Closely (1)flavoxate and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.flecainideMonitor Closely (1)flecainide and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.fluconazoleSerious - Use Alternative (1)fluconazole and formoterol both increase QTc interval. Avoid or Use Alternate Drug.fluoxetineMonitor Closely (1)fluoxetine and formoterol both increase QTc interval. Modify Therapy/Monitor Closely. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular systemfluphenazineMonitor Closely (3)aclidinium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. fluphenazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)fluphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.flurazepamMonitor Closely (1)flurazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurbiprofenMonitor Closely (1)flurbiprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluvoxamineMonitor Closely (1)fluvoxamine and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.foscarnetMonitor Closely (1)formoterol and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.fostemsavirMonitor Closely (1)formoterol and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. furosemideMonitor Closely (1)formoterol and furosemide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.galantamineMonitor Closely (1)galantamine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)galantamine decreases effects of aclidinium by pharmacodynamic antagonism. Minor/Significance Unknown.gemifloxacinMonitor Closely (1)gemifloxacin and formoterol both increase QTc interval. Use Caution/Monitor.gentamicinMonitor Closely (1)formoterol and gentamicin both decrease serum potassium. Use Caution/Monitor.gilteritinibMonitor Closely (1)gilteritinib and formoterol both increase QTc interval. Use Caution/Monitor.glasdegibSerious - Use Alternative (1)formoterol and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.glucagonSerious - Use Alternative (1)glucagon increases toxicity of aclidinium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .glucagon intranasalSerious - Use Alternative (1)glucagon intranasal increases toxicity of aclidinium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .glycopyrrolateMonitor Closely (1)glycopyrrolate and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrrolate inhaledMonitor Closely (1)glycopyrrolate inhaled and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrronium tosylate topicalMonitor Closely (1)glycopyrronium tosylate topical, aclidinium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.goserelinMonitor Closely (1)goserelin increases toxicity of formoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.green teaMinor (1)green tea increases effects of formoterol by pharmacodynamic synergism. Minor/Significance Unknown. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.haloperidolMonitor Closely (3)haloperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. haloperidol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. aclidinium decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.Serious - Use Alternative (1)formoterol and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.henbaneMonitor Closely (1)henbane and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.histrelinMonitor Closely (1)histrelin increases toxicity of formoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.homatropineMonitor Closely (1)homatropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine AMonitor Closely (1)huperzine A increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydrochlorothiazideMonitor Closely (1)formoterol and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.hydromorphoneMonitor Closely (1)hydromorphone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydroxychloroquine sulfateSerious - Use Alternative (1)hydroxychloroquine sulfate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzineMonitor Closely (1)hydroxyzine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hyoscyamineMonitor Closely (1)hyoscyamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.hyoscyamine sprayMonitor Closely (1)hyoscyamine spray and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.ibuprofenMonitor Closely (1)ibuprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen IVMonitor Closely (1)ibuprofen IV increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibutilideSerious - Use Alternative (1)formoterol and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.iloperidoneMonitor Closely (4)iloperidone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. aclidinium decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor. iloperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. formoterol and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely.imipramineMonitor Closely (2)aclidinium and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. imipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)imipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug. imipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.indapamideMonitor Closely (1)formoterol and indapamide both decrease serum potassium. Use Caution/Monitor.Serious - Use Alternative (1)formoterol and indapamide both increase QTc interval. Avoid or Use Alternate Drug.Minor (1)formoterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.indomethacinMonitor Closely (1)indomethacin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.inotuzumabSerious - Use Alternative (1)inotuzumab and formoterol both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.ipratropiumMonitor Closely (1)ipratropium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.isocarboxazidSerious - Use Alternative (1)isocarboxazid increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.isoproterenolMonitor Closely (3)formoterol and isoproterenol both decrease serum potassium. Use Caution/Monitor. formoterol and isoproterenol both decrease sedation. Use Caution/Monitor. formoterol and isoproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.itraconazoleMonitor Closely (1)itraconazole and formoterol both increase QTc interval. Use Caution/Monitor.ivosidenibSerious - Use Alternative (1)ivosidenib and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazoleSerious - Use Alternative (1)formoterol and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.ketoprofenMonitor Closely (1)ketoprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolacMonitor Closely (1)ketorolac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolac intranasalMonitor Closely (1)ketorolac intranasal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .ketotifen, ophthalmicMonitor Closely (1)ketotifen, ophthalmic increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.labetalolMonitor Closely (2)labetalol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. labetalol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.lapatinibMonitor Closely (1)formoterol and lapatinib both increase