Caution/Monitor.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl and maprotiline both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone and maprotiline both increase sedation. Use Caution/Monitor.disopyramideContraindicated (1)maprotiline and disopyramide both increase QTc interval. Contraindicated.dobutamineMonitor Closely (1)maprotiline increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilideSerious - Use Alternative (2)maprotiline and dofetilide both increase QTc interval. Avoid or Use Alternate Drug. dofetilide increases toxicity of maprotiline by QTc interval. Avoid or Use Alternate Drug.dolasetronMonitor Closely (1)maprotiline and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.donepezilMonitor Closely (2)donepezil increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. donepezil and maprotiline both increase QTc interval. Use Caution/Monitor.dopamineMonitor Closely (1)maprotiline increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexamineMonitor Closely (1)maprotiline increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.doxepinMonitor Closely (2)doxepin and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin and maprotiline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. doxepin and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.doxylamineMonitor Closely (1)doxylamine and maprotiline both increase sedation. Use Caution/Monitor.dronedaroneSerious - Use Alternative (1)maprotiline and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolMonitor Closely (1)droperidol and maprotiline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineSerious - Use Alternative (1)duloxetine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.echothiophate iodideMonitor Closely (1)echothiophate iodide increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.efavirenzMonitor Closely (1)efavirenz and maprotiline both increase QTc interval. Use Caution/Monitor.eletriptanMonitor Closely (1)eletriptan and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.eliglustatMonitor Closely (1)eliglustat increases levels of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.Serious - Use Alternative (1)eliglustat and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.elvitegravir/cobicistat/emtricitabine/tenofovir DFMonitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.encorafenibSerious - Use Alternative (1)encorafenib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.entrectinibSerious - Use Alternative (1)entrectinib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.ephedrineMonitor Closely (2)maprotiline increases effects of ephedrine by unknown mechanism. Use Caution/Monitor. maprotiline increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineMonitor Closely (2)maprotiline increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. maprotiline increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. maprotiline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine racemicMonitor Closely (2)maprotiline increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor. maprotiline increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. maprotiline, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ergotamineMonitor Closely (1)maprotiline and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.eribulinSerious - Use Alternative (1)eribulin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseSerious - Use Alternative (1)maprotiline and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)maprotiline and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)maprotiline and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)maprotiline and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramMonitor Closely (1)escitalopram increases toxicity of maprotiline by QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)escitalopram and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.esketamine intranasalMonitor Closely (1)esketamine intranasal, maprotiline. Either increases toxicity of the other by sedation. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam and maprotiline both increase sedation. Use Caution/Monitor.estradiolMinor (1)estradiol, maprotiline. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.estrogens conjugated syntheticMinor (1)estrogens conjugated synthetic, maprotiline. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.estrogens esterifiedMinor (1)estrogens esterified, maprotiline. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.estropipateMinor (1)estropipate, maprotiline. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.ethanolMonitor Closely (1)maprotiline and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and maprotiline both increase sedation. Use Caution/Monitor.Minor (1)etomidate, maprotiline. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.eucalyptusMinor (1)maprotiline and eucalyptus both increase sedation. Minor/Significance Unknown.ezogabineMonitor Closely (1)ezogabine, maprotiline. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.fedratinibMonitor Closely (1)fedratinib will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary.fenfluramineMonitor Closely (3)fenfluramine, maprotiline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome. maprotiline and fenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely. maprotiline increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fesoterodineMonitor Closely (1)fesoterodine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.fingolimodMonitor Closely (1)fingolimod and maprotiline both increase QTc interval. Use Caution/Monitor.flavoxateMonitor Closely (1)flavoxate and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.flecainideMonitor Closely (1)maprotiline and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.fluconazoleSerious - Use Alternative (1)maprotiline and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetineMonitor Closely (1)maprotiline and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)fluoxetine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.fluphenazineMonitor Closely (1)fluphenazine and maprotiline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)fluphenazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)maprotiline, fluphenazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects. maprotiline, fluphenazine. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.flurazepamMonitor Closely (1)flurazepam and maprotiline both increase sedation. Use Caution/Monitor.fluvoxamineMonitor Closely (1)fluvoxamine and maprotiline both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)fluvoxamine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.formoterolMonitor Closely (1)maprotiline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)maprotiline and formoterol both increase QTc interval. Avoid or Use Alternate Drug. maprotiline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fosamprenavirSerious - Use Alternative (1)fosamprenavir increases levels of maprotiline by decreasing metabolism. Avoid or Use Alternate Drug.foscarnetMonitor Closely (1)maprotiline and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.frovatriptanMonitor Closely (1)frovatriptan and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.gabapentinMonitor Closely (1)gabapentin, maprotiline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, maprotiline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.galantamineMonitor Closely (1)galantamine increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.ganaxoloneMonitor Closely (1)maprotiline and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinMonitor Closely (1)gemifloxacin and maprotiline both increase QTc interval. Use Caution/Monitor.gilteritinibMonitor Closely (1)gilteritinib and maprotiline both increase QTc interval. Use Caution/Monitor.givosiranSerious - Use Alternative (1)givosiran will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.glimepirideMinor (1)maprotiline increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.glipizideMinor (1)maprotiline increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.glyburideMinor (1)maprotiline increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.glycopyrrolateMonitor Closely (2)glycopyrrolate and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. maprotiline increases levels of glycopyrrolate by unknown mechanism. Use Caution/Monitor.glycopyrrolate inhaledMonitor Closely (2)glycopyrrolate inhaled and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. maprotiline increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor.granisetronMonitor Closely (1)granisetron and maprotiline both increase QTc interval. Use Caution/Monitor.guanfacineSerious - Use Alternative (1)maprotiline decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.haloperidolMonitor Closely (1)haloperidol and maprotiline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.henbaneMonitor Closely (1)henbane and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.homatropineMonitor Closely (1)homatropine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine AMonitor Closely (1)huperzine A increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydrocodoneMonitor Closely (1)hydrocodone, maprotiline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.hydromorphoneMonitor Closely (1)hydromorphone and maprotiline both increase sedation. Use Caution/Monitor.hydroxychloroquine sulfateSerious - Use Alternative (1)hydroxychloroquine sulfate and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.hydroxyprogesterone caproate (DSC)Minor (1)hydroxyprogesterone caproate (DSC), maprotiline. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.hydroxyzineMonitor Closely (2)hydroxyzine and maprotiline both increase QTc interval. Use Caution/Monitor. hydroxyzine and maprotiline both increase sedation. Use Caution/Monitor.hyoscyamineMonitor Closely (1)hyoscyamine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.hyoscyamine sprayMonitor Closely (1)hyoscyamine spray and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.ibutilideContraindicated (1)maprotiline and ibutilide both increase QTc interval. Contraindicated.iloperidoneMonitor Closely (2)maprotiline and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely. iloperidone and maprotiline both increase sedation. Use Caution/Monitor.imipramineMonitor Closely (2)imipramine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. imipramine and maprotiline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)imipramine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. imipramine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.indacaterol, inhaledMonitor Closely (1)indacaterol, inhaled, maprotiline. QTc interval. Use Caution/Monitor. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular