AdultPediatricDosage Forms & Strengths tablet 500mg Elevated Urinary pH 1-2 tabs (500-1000mg) dissolved in 6-8 oz of water; take PO four times daily with meals and at bedtimeSafety and efficacy not establishedInteraction CheckerEnter a drug name and potassium acid phosphateNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (9)amilorideamiloride and potassium acid phosphate both increase serum potassium. Avoid or Use Alternate Drug.drospirenonedrospirenone and potassium acid phosphate both increase serum potassium. Avoid or Use Alternate Drug.eplerenonepotassium acid phosphate, eplerenone. Mechanism: pharmacodynamic synergism. Contraindicated. Hyperkalemia.erdafitinibpotassium acid phosphate, erdafitinib. Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid coadministration during initial dosing adjustment period (ie, first 21 days). Increases in serum phosphate levels are a pharmacodynamic effect of FGFR inhibition. Serum phosphate binders may obscure decisions regarding initial dosage increase.potassium chloridepotassium acid phosphate and potassium chloride both increase serum potassium. Avoid or Use Alternate Drug.potassium citratepotassium acid phosphate and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.potassium phosphates, IVpotassium acid phosphate and potassium phosphates, IV both increase serum potassium. Avoid or Use Alternate Drug.spironolactonespironolactone and potassium acid phosphate both increase serum potassium. Avoid or Use Alternate Drug.triamterenetriamterene and potassium acid phosphate both increase serum potassium. Avoid or Use Alternate Drug.Monitor Closely (109)acebutololacebutolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.aceclofenacaceclofenac and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.acemetacinacemetacin and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.albuterolpotassium acid phosphate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.arformoterolpotassium acid phosphate increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.aspirinaspirin and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.aspirin rectalaspirin rectal and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.atenololatenolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.benazeprilbenazepril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.potassium acid phosphate and benazepril both increase serum potassium. Use Caution/Monitor. Potassium salts may increase the hyperkalemic effects of ACE inhibitors; the effect may be the result of aldosterone suppression in patients receiving ACE inhibitorsbendroflumethiazidepotassium acid phosphate increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.betaxololbetaxolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.bisoprololbisoprolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.bumetanidepotassium acid phosphate increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.canagliflozinpotassium acid phosphate and canagliflozin both increase serum potassium. Modify Therapy/Monitor Closely.candesartancandesartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.captoprilcaptopril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.carbenoxolonepotassium acid phosphate increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.carvedilolcarvedilol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.celecoxibcelecoxib and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.celiprololceliprolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.chlorothiazidepotassium acid phosphate increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.chlorthalidonepotassium acid phosphate increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.choline magnesium trisalicylatecholine magnesium trisalicylate and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.cyclopenthiazidepotassium acid phosphate increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.dextroamphetamine transdermalpotassium acid phosphate will decrease the level or effect of dextroamphetamine transdermal by Other (see comment). Modify Therapy/Monitor Closely. Urinary acidifying agents can lower blood levels and efficacy of amphetamines. Increase dose of dextroamphetamine transdermal based on clinical response.diclofenacdiclofenac and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.diflunisaldiflunisal and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.digoxinpotassium acid phosphate and digoxin both increase serum potassium. Modify Therapy/Monitor Closely.disopyramidepotassium acid phosphate increases effects of disopyramide by pharmacodynamic synergism. Use Caution/Monitor. Additive cardiovascular depression.dobutaminepotassium acid phosphate increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.dopexaminepotassium acid phosphate increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.enalaprilenalapril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.ephedrinepotassium acid phosphate increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.epinephrinepotassium acid phosphate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.epinephrine racemicpotassium acid phosphate increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.eprosartaneprosartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.esmololesmolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.ethacrynic acidpotassium acid phosphate increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.etodolacetodolac and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.fenoprofenfenoprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.finerenonepotassium acid phosphate and finerenone both increase serum potassium. Modify Therapy/Monitor Closely. Finerenone dose adjustment based on current serum potassium concentration. Monitor serum potassium and adjust finerenone dose as described in the prescribing information as necessary.flurbiprofenflurbiprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.formoterolpotassium acid phosphate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.fosinoprilfosinopril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.furosemidepotassium acid phosphate increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.gentamicinpotassium acid phosphate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.hydrochlorothiazidepotassium acid phosphate increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.ibuprofenibuprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.ibuprofen IVibuprofen IV and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.imidaprilimidapril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.indapamidepotassium acid phosphate increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.indomethacinindomethacin and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.irbesartanirbesartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.isoproterenolpotassium acid phosphate increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.ketoprofenketoprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.ketorolacketorolac and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.ketorolac intranasalketorolac intranasal and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.labetalollabetalol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.levalbuterolpotassium acid phosphate increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.lisinoprillisinopril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.lornoxicamlornoxicam and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.losartanlosartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.meclofenamatemeclofenamate and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.mefenamic acidmefenamic acid and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.meloxicammeloxicam and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.metaproterenolpotassium acid phosphate increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.methyclothiazidepotassium acid phosphate increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. .metolazonepotassium acid phosphate increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.metoprololmetoprolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.moexiprilmoexipril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.nabumetonenabumetone and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.nadololnadolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.naproxennaproxen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.nebivololnebivolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.noni juicepotassium acid phosphate and noni juice both increase serum potassium. Use Caution/Monitor.norepinephrinepotassium acid phosphate increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.olmesartanolmesartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.oxaprozinoxaprozin and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.parecoxibparecoxib and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.penbutololpenbutolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.perindoprilperindopril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.pindololpindolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.pirbuterolpotassium acid phosphate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.piroxicampiroxicam and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.potassium citrate/citric acidpotassium acid phosphate and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.propranololpropranolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.quinaprilquinapril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.ramiprilramipril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.sacubitril/valsartansacubitril/valsartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.salicylates (non-asa)salicylates (non-asa) and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.salmeterolpotassium acid phosphate increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.salsalatesalsalate and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.sotalolsotalol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.sparsentansparsentan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor. Monitor serum potassium frequently.succinylcholinepotassium acid phosphate and succinylcholine both increase serum potassium. Modify Therapy/Monitor Closely.sulfasalazinesulfasalazine and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.sulindacsulindac and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.telmisartantelmisartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.terbutalinepotassium acid phosphate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.timololtimolol and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.tolfenamic acidtolfenamic acid and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.tolmetintolmetin and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.tolvaptanpotassium acid phosphate and tolvaptan both increase serum potassium. Modify Therapy/Monitor Closely.torsemidepotassium acid phosphate increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.trandolapriltrandolapril increases levels of potassium acid phosphate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.trimethoprimtrimethoprim and potassium acid phosphate both increase serum potassium. Use Caution/Monitor. Trimethoprim decreases urinary potassium excretion. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia.valsartanvalsartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.voclosporinvoclosporin and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.Minor (29)acarbosepotassium acid phosphate increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.amphotericin B deoxycholateamphotericin B deoxycholate decreases levels of potassium acid phosphate by increasing renal clearance. Minor/Significance Unknown.bisacodylbisacodyl decreases levels of potassium acid phosphate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.bisacodyl rectalbisacodyl rectal decreases levels of potassium acid phosphate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.cadexomer iodinecadexomer iodine increases levels of potassium acid phosphate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.chlorpropamidepotassium acid phosphate increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.glimepiridepotassium acid phosphate increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.glipizidepotassium acid phosphate increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.glyburidepotassium acid phosphate increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin aspartpotassium acid phosphate increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin detemirpotassium acid phosphate increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin glarginepotassium acid phosphate increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin