by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.midazolammidazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midodrinecaffeine and midodrine both decrease sedation. Use Caution/Monitor.mirtazapinemirtazapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.modafinilcaffeine and modafinil both decrease sedation. Use Caution/Monitor.morphinemorphine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.motherwortmotherwort increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.moxonidinemoxonidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabilonenabilone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nalbuphinenalbuphine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.norepinephrinenorepinephrine and caffeine both decrease sedation. Use Caution/Monitor.nortriptylinenortriptyline increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.olanzapineolanzapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.opium tinctureopium tincture increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxazepamoxazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxycodoneoxycodone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxymorphoneoxymorphone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.paliperidonepaliperidone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.papaveretumpapaveretum increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pefloxacinpefloxacin will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.pentazocinepentazocine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pentobarbitalpentobarbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.perphenazineperphenazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phendimetrazinecaffeine and phendimetrazine both decrease sedation. Use Caution/Monitor.phenobarbitalphenobarbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenterminecaffeine and phentermine both decrease sedation. Use Caution/Monitor.phenylephrinecaffeine and phenylephrine both decrease sedation. Use Caution/Monitor.phenylephrine POcaffeine and phenylephrine PO both decrease sedation. Use Caution/Monitor.pholcodinepholcodine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozidepimozide increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pirbuterolpirbuterol and caffeine both decrease sedation. Use Caution/Monitor.primidoneprimidone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazineprochlorperazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.promethazinepromethazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.propylhexedrinecaffeine and propylhexedrine both decrease sedation. Use Caution/Monitor.protriptylineprotriptyline increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.quazepamquazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.quetiapinequetiapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.rasagilinerasagiline increases effects of caffeine by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode.risperidonerisperidone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.rucaparibrucaparib will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP1A2 substrates, if clinically indicated.salmeterolsalmeterol and caffeine both decrease sedation. Use Caution/Monitor.scullcapscullcap increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.secobarbitalsecobarbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.selegilineselegiline increases effects of caffeine by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode.shepherd's purseshepherd's purse increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.solriamfetolcaffeine and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.stiripentolstiripentol, caffeine. affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP1A2 inhibitor and inducer. Monitor CYP1A2 substrates coadministered with stiripentol for increased or decreased effects. CYP1A2 substrates may require dosage adjustment.sufentanilsufentanil increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.tapentadoltapentadol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.temazepamtemazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.terbutalineterbutaline and caffeine both decrease sedation. Use Caution/Monitor.teriflunomideteriflunomide decreases levels of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.thioridazinethioridazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thiothixenethiothixene increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.topiramatetopiramate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.tramadoltramadol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodonetrazodone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triazolamtriazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triclofostriclofos increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trifluoperazinetrifluoperazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trimipraminetrimipramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triprolidinetriprolidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.xylometazolinecaffeine and xylometazoline both decrease sedation. Use Caution/Monitor.yohimbinecaffeine and yohimbine both decrease sedation. Use Caution/Monitor.ziconotideziconotide increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziprasidoneziprasidone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (47)adenosinecaffeine decreases effects of adenosine by pharmacodynamic antagonism. Minor/Significance Unknown.amantadineamantadine, caffeine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Potential for additive CNS stimulation.American ginsengAmerican ginseng increases effects of caffeine by pharmacodynamic synergism. Minor/Significance Unknown.amobarbitalamobarbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.armodafinilarmodafinil will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.butabarbitalbutabarbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.butalbitalbutalbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.calcium acetatecaffeine decreases levels of calcium acetate by increasing renal clearance. Minor/Significance Unknown.calcium carbonatecaffeine decreases levels of calcium carbonate by increasing renal clearance. Minor/Significance Unknown.calcium chloridecaffeine decreases levels of calcium chloride by increasing renal clearance. Minor/Significance Unknown.calcium citratecaffeine decreases levels of calcium citrate by increasing renal clearance. Minor/Significance Unknown.calcium gluconatecaffeine decreases levels of calcium gluconate by increasing renal clearance. Minor/Significance Unknown.carbamazepinecarbamazepine will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.cigarette smokingcigarette smoking will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.cimetidinecimetidine will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.clotrimazoleclotrimazole increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.erythromycin baseerythromycin base will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.erythromycin ethylsuccinateerythromycin ethylsuccinate will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.erythromycin lactobionateerythromycin lactobionate will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.erythromycin stearateerythromycin stearate will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.eucalyptuseucalyptus increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.fluconazolefluconazole increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.grapefruitgrapefruit increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.guaranaguarana increases effects of caffeine by pharmacodynamic synergism. Minor/Significance Unknown.isoniazidisoniazid will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.itraconazoleitraconazole increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.ketoconazoleketoconazole increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.levoketoconazolelevoketoconazole increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.mexiletinemexiletine will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.miconazole vaginalmiconazole vaginal increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.modafinilmodafinil will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.peginterferon alfa 2apeginterferon alfa 2a will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.pentobarbitalpentobarbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.phenobarbitalphenobarbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.pipemidic acidpipemidic acid will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.posaconazoleposaconazole increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.primidoneprimidone will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.rifampinrifampin will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.sagesage increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.secobarbitalsecobarbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.smokingsmoking will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.thiaminecaffeine decreases levels of thiamine by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Coffee, tea are high in anti-thiamine factors.tobacco usetobacco use will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.verapamilverapamil will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.voriconazolevoriconazole increases levels of caffeine by decreasing metabolism. Minor/Significance Unknown.yerba mateyerba mate increases effects of caffeine by pharmacodynamic synergism. Minor/Significance Unknown.zileutonzileuton will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.abametapirSerious - Use Alternative (1)abametapir will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP1A2 substrates. If not feasible, avoid use of abametapir.adenosineMinor (1)caffeine decreases effects of adenosine by pharmacodynamic antagonism. Minor/Significance Unknown.albuterolMonitor Closely (1)albuterol and caffeine both decrease sedation. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amantadineMinor (1)amantadine, caffeine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Potential for additive CNS stimulation.American ginsengMinor (1)American ginseng increases effects of caffeine by pharmacodynamic synergism. Minor/Significance Unknown.amitriptylineMonitor Closely (1)amitriptyline increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)amobarbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.amoxapineMonitor Closely (1)amoxapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterolMonitor Closely (1)arformoterol and caffeine both decrease sedation. Use Caution/Monitor.aripiprazoleMonitor Closely (1)aripiprazole increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilMonitor Closely (1)armodafinil and caffeine both decrease sedation. Use Caution/Monitor.Minor (1)armodafinil will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.azelastineMonitor Closely (1)azelastine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)belladonna and opium increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benperidolMonitor Closely (1)benperidol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetamineMonitor Closely (1)caffeine and benzphetamine both decrease sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)buprenorphine buccal increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bupropionSerious - Use Alternative (1)caffeine increases toxicity of bupropion by unspecified interaction mechanism. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible.butabarbitalMonitor Closely (1)butabarbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)butabarbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.butalbitalMonitor Closely (1)butalbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)butalbital will decrease the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.butorphanolMonitor Closely