AdultPediatricGeriatricDosage Forms & Strengths tablet 25mg Insomnia 25 mg PO qHS PRN 30 min before bedtimeInsomnia <12 years: Not recommended >12 years: 25 mg PO qHS PRN 30 min before bedtimeAvoid use in elderly because of high incidence of anticholinergic effects Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity May exacerbate existing lower urinary conditions or benign prostatic hyperplasia Tolerance develops when used as hypnoticInteraction CheckerEnter a drug name and doxylamineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (17)benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.calcium/magnesium/potassium/sodium oxybatesdoxylamine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.fentanylfentanyl, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalfentanyl intranasal, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.hydrocodonehydrocodone, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.isocarboxazidisocarboxazid increases effects of doxylamine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .lemborexantlemborexant, doxylamine. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.methylene bluemethylene blue and doxylamine both increase serotonin levels. Avoid or Use Alternate Drug. If drug combination must be administered, monitor for evidence of serotonergic or opioid-related toxicitiesmetoclopramide intranasaldoxylamine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olopatadine intranasaldoxylamine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. selinexorselinexor, doxylamine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sodium oxybatedoxylamine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.sufentanil SLsufentanil SL, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.tranylcyprominetranylcypromine increases effects of doxylamine by Other (see comment). Avoid or Use Alternate Drug. Comment: Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .valerianvalerian and doxylamine both increase sedation. Avoid or Use Alternate Drug.Monitor Closely (178)acrivastineacrivastine and doxylamine both increase sedation. Use Caution/Monitor.alfentanildoxylamine and alfentanil both increase sedation. Use Caution/Monitor.alprazolamalprazolam and doxylamine both increase sedation. Use Caution/Monitor.amifampridinedoxylamine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.amisulprideamisulpride and doxylamine both increase sedation. Use Caution/Monitor.amitriptylinedoxylamine and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and doxylamine both increase sedation. Use Caution/Monitor.amoxapinedoxylamine and amoxapine both increase sedation. Use Caution/Monitor.apomorphinedoxylamine and apomorphine both increase sedation. Use Caution/Monitor.aripiprazoledoxylamine and aripiprazole both increase sedation. Use Caution/Monitor.asenapineasenapine and doxylamine both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and doxylamine both increase sedation. Use Caution/Monitor.avapritinibavapritinib and doxylamine both increase sedation. Use Caution/Monitor.azelastineazelastine and doxylamine both increase sedation. Use Caution/Monitor.baclofendoxylamine and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumdoxylamine and belladonna and opium both increase sedation. Use Caution/Monitor.benperidoldoxylamine and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen and doxylamine both increase sedation. Use Caution/Monitor.benzphetaminedoxylamine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanolonebrexanolone, doxylamine. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and doxylamine both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and doxylamine both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and doxylamine both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and doxylamine both increase sedation. Use Caution/Monitor.buprenorphinedoxylamine and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccaldoxylamine and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and doxylamine both increase sedation. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and doxylamine both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectiondoxylamine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.buprenorphine, long-acting injection and doxylamine both increase sedation. Use Caution/Monitor.butabarbitalbutabarbital and doxylamine both increase sedation. Use Caution/Monitor.butalbitalbutalbital and doxylamine both increase sedation. Use Caution/Monitor.butorphanoldoxylamine and butorphanol both increase sedation. Use Caution/Monitor.carbinoxaminecarbinoxamine and doxylamine both increase sedation. Use Caution/Monitor.carisoprodoldoxylamine and carisoprodol both increase sedation. Use Caution/Monitor.cenobamatecenobamate, doxylamine. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydratechloral hydrate and doxylamine both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and doxylamine both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.chlorpromazinedoxylamine and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazonedoxylamine and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizinecinnarizine and doxylamine both increase sedation. Use Caution/Monitor.clemastineclemastine and doxylamine both increase sedation. Use Caution/Monitor.clobazamdoxylamine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipraminedoxylamine and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and doxylamine both increase sedation. Use Caution/Monitor.clonidineclonidine, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateclorazepate and doxylamine both increase sedation. Use Caution/Monitor.clozapinedoxylamine and clozapine both increase sedation. Use Caution/Monitor.codeinedoxylamine and codeine both increase sedation. Use Caution/Monitor.cyclizinecyclizine and doxylamine both increase sedation. Use Caution/Monitor.cyclobenzaprinedoxylamine and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and doxylamine both increase sedation. Use Caution/Monitor.dantrolenedoxylamine and dantrolene both increase sedation. Use Caution/Monitor.daridorexantdoxylamine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desipraminedoxylamine and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazinedoxylamine and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.dexfenfluraminedoxylamine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinedexmedetomidine and doxylamine both increase sedation. Use Caution/Monitor.dextromoramidedoxylamine and dextromoramide both increase sedation. Use Caution/Monitor.diamorphinedoxylamine and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiazepam and doxylamine both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.difelikefalindifelikefalin and doxylamine both increase sedation. Use Caution/Monitor.difenoxin hcldoxylamine and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and doxylamine both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and doxylamine both increase sedation. Use Caution/Monitor.diphenoxylate hcldoxylamine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanonedoxylamine and dipipanone both increase sedation. Use Caution/Monitor.dopexaminedoxylamine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepindoxylamine and dosulepin both increase sedation. Use Caution/Monitor.doxepindoxylamine and doxepin both increase sedation. Use Caution/Monitor.droperidoldoxylamine and droperidol both increase sedation. Use Caution/Monitor.esketamine intranasalesketamine intranasal, doxylamine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and doxylamine both increase sedation. Use Caution/Monitor.ethanoldoxylamine and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and doxylamine both increase sedation. Use Caution/Monitor.fenfluraminedoxylamine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserindoxylamine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazinedoxylamine and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and doxylamine both increase sedation. Use Caution/Monitor.gabapentingabapentin, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxolonedoxylamine and ganaxolone both increase sedation. Use Caution/Monitor.gotu kolagotu kola increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.haloperidoldoxylamine and haloperidol both increase sedation. Use Caution/Monitor.hawthornhawthorn increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.hopshops increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.hyaluronidasedoxylamine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect. .hydromorphonedoxylamine and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and doxylamine both increase sedation. Use Caution/Monitor.iloperidonedoxylamine and iloperidone both increase sedation. Use Caution/Monitor.imipraminedoxylamine and imipramine both increase sedation. Use Caution/Monitor.kavakava increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.ketamineketamine and doxylamine both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicdoxylamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, doxylamine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.levorphanoldoxylamine and levorphanol both increase sedation. Use Caution/Monitor.lofepraminedoxylamine and lofepramine both increase sedation. Use Caution/Monitor.lofexidinedoxylamine and lofexidine both increase sedation. Use Caution/Monitor.loprazolamloprazolam and doxylamine both increase sedation. Use Caution/Monitor.lorazepamlorazepam and doxylamine both increase sedation. Use Caution/Monitor.lormetazepamlormetazepam and doxylamine both increase sedation. Use Caution/Monitor.loxapinedoxylamine and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaleddoxylamine and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, doxylamine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilinedoxylamine