Use Alternate Drug.escitalopramSerious - Use Alternative (1)asenapine transdermal and escitalopram both increase QTc interval. Avoid or Use Alternate Drug.esketamine intranasalMonitor Closely (1)asenapine transdermal and esketamine intranasal both increase sedation. Use Caution/Monitor.estazolamMonitor Closely (1)asenapine transdermal and estazolam both increase sedation. Use Caution/Monitor.eszopicloneMonitor Closely (1)asenapine transdermal and eszopiclone both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (1)asenapine transdermal and ethanol both increase sedation. Use Caution/Monitor.ethosuximideMonitor Closely (1)asenapine transdermal and ethosuximide both increase sedation. Use Caution/Monitor.ethotoinMonitor Closely (1)asenapine transdermal and ethotoin both increase sedation. Use Caution/Monitor.ezogabineMonitor Closely (1)asenapine transdermal and ezogabine both increase QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed, particularly when dose titrated to 1200mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.felbamateMonitor Closely (1)asenapine transdermal and felbamate both increase sedation. Use Caution/Monitor.fenfluramineMonitor Closely (2)asenapine transdermal decreases effects of fenfluramine by pharmacodynamic antagonism. Use Caution/Monitor. Potent serotonin receptor antagonists may decrease fenfluramine efficacy. If coadministered, monitor appropriately. asenapine transdermal and fenfluramine both increase sedation. Use Caution/Monitor.fentanylSerious - Use Alternative (1)asenapine transdermal and fentanyl both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl intranasalSerious - Use Alternative (1)asenapine transdermal and fentanyl intranasal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl iontophoretic transdermal systemSerious - Use Alternative (1)asenapine transdermal and fentanyl iontophoretic transdermal system both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl transdermalSerious - Use Alternative (1)asenapine transdermal and fentanyl transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl transmucosalSerious - Use Alternative (1)asenapine transdermal and fentanyl transmucosal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefexinidazoleSerious - Use Alternative (1)fexinidazole and asenapine transdermal both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval. fexofenadineMonitor Closely (1)asenapine transdermal and fexofenadine both increase sedation. Use Caution/Monitor.fingolimodSerious - Use Alternative (1)asenapine transdermal and fingolimod both increase QTc interval. Avoid or Use Alternate Drug.flecainideSerious - Use Alternative (1)asenapine transdermal and flecainide both increase QTc interval. Avoid or Use Alternate Drug.flibanserinMonitor Closely (1)asenapine transdermal and flibanserin both increase sedation. Use Caution/Monitor.fluconazoleSerious - Use Alternative (1)asenapine transdermal and fluconazole both increase QTc interval. Contraindicated.fluoxetineMonitor Closely (1)asenapine transdermal and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazineMonitor Closely (2)asenapine transdermal and fluphenazine both increase QTc interval. Use Caution/Monitor. asenapine transdermal and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)asenapine transdermal and flurazepam both increase sedation. Use Caution/Monitor.fluvoxamineMonitor Closely (1)fluvoxamine will increase the level or effect of asenapine transdermal by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Dose reduction may be necessarySerious - Use Alternative (1)asenapine transdermal and fluvoxamine both increase QTc interval. Avoid or Use Alternate Drug.formoterolMonitor Closely (1)asenapine transdermal and formoterol both increase QTc interval. Use Caution/Monitor.foscarnetSerious - Use Alternative (1)asenapine transdermal and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.fostemsavirMonitor Closely (1)asenapine transdermal and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.gabapentinMonitor Closely (1)asenapine transdermal and gabapentin both increase sedation. Use Caution/Monitor.ganaxoloneMonitor Closely (1)asenapine transdermal and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinSerious - Use Alternative (1)asenapine transdermal and gemifloxacin both increase QTc interval. Avoid or Use Alternate Drug.gemtuzumabMonitor Closely (1)asenapine transdermal and gemtuzumab both increase QTc interval. Use Caution/Monitor.gilteritinibSerious - Use Alternative (1)asenapine transdermal and gilteritinib both increase QTc interval. Avoid or Use Alternate Drug.glasdegibSerious - Use Alternative (1)asenapine transdermal and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.goserelinSerious - Use Alternative (1)asenapine transdermal and goserelin both increase QTc interval. Avoid or Use Alternate Drug.granisetronSerious - Use Alternative (1)asenapine transdermal and granisetron both increase QTc interval. Avoid or Use Alternate Drug.guanfacineMonitor Closely (1)asenapine transdermal and guanfacine both increase sedation. Use Caution/Monitor.haloperidolMonitor Closely (2)asenapine transdermal and haloperidol both increase QTc interval. Use Caution/Monitor. asenapine transdermal and haloperidol both increase sedation. Use Caution/Monitor.histrelinSerious - Use Alternative (1)asenapine transdermal and histrelin both increase QTc interval. Avoid or Use Alternate Drug.hydrocodoneSerious - Use Alternative (1)asenapine transdermal and hydrocodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatehydromorphoneSerious - Use Alternative (1)asenapine transdermal and hydromorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatehydroxychloroquine sulfateSerious - Use Alternative (1)asenapine transdermal and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzineMonitor Closely (1)asenapine transdermal and hydroxyzine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.ibutilideSerious - Use Alternative (1)asenapine transdermal and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.iloperidoneMonitor Closely (1)asenapine transdermal and iloperidone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.imipramineMonitor Closely (2)asenapine transdermal and imipramine both increase sedation. Use Caution/Monitor. asenapine transdermal and imipramine both increase QTc interval. Use Caution/Monitor.indacaterol, inhaledMonitor Closely (1)asenapine transdermal and indacaterol, inhaled both increase QTc interval. Use Caution/Monitor.indapamideMonitor Closely (1)asenapine transdermal and indapamide both increase QTc interval. Use Caution/Monitor.inotuzumabSerious - Use Alternative (1)asenapine transdermal and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.isofluraneMonitor Closely (1)asenapine transdermal and isoflurane both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.isradipineMonitor Closely (1)asenapine transdermal and isradipine both increase QTc interval. Use Caution/Monitor.itraconazoleSerious - Use Alternative (1)asenapine transdermal and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibSerious - Use Alternative (1)asenapine transdermal and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.ketamineMonitor Closely (1)asenapine transdermal and ketamine both increase sedation. Use Caution/Monitor.ketotifen, drug-eluting contact lensMonitor Closely (1)asenapine transdermal and ketotifen, drug-eluting contact lens both increase sedation. Use Caution/Monitor.lamotrigineMonitor Closely (1)asenapine transdermal and lamotrigine both increase sedation. Use Caution/Monitor.lapatinibSerious - Use Alternative (1)asenapine transdermal and lapatinib both increase QTc interval. Avoid or Use Alternate Drug.lasmiditanMonitor Closely (1)lasmiditan, asenapine transdermal. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lefamulinSerious - Use Alternative (1)asenapine transdermal and lefamulin both increase QTc interval. Avoid or Use Alternate Drug.lemborexantMonitor Closely (1)lemborexant, asenapine transdermal. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lenvatinibMonitor Closely (1)asenapine transdermal and lenvatinib both increase QTc interval. Use Caution/Monitor.leuprolideSerious - Use Alternative (1)asenapine transdermal and leuprolide both increase QTc interval. Avoid or Use Alternate Drug.levetiracetamMonitor Closely (1)asenapine transdermal and levetiracetam both increase sedation. Use Caution/Monitor.levocetirizineMonitor Closely (1)asenapine transdermal and levocetirizine both increase sedation. Use Caution/Monitor.levodopa inhaledSerious - Use Alternative (1)asenapine transdermal decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Atypical (2nd generation) antipsychotics inhibit dopamine D2 receptors in varying degrees (clozapine and quetiapine are lower risk). .levofloxacinSerious - Use Alternative (1)asenapine transdermal and levofloxacin both increase QTc interval. Avoid or Use Alternate Drug.levorphanolMonitor Closely (1)asenapine transdermal and levorphanol both increase sedation. Use Caution/Monitor.lithiumSerious - Use Alternative (1)asenapine transdermal and lithium both increase QTc interval. Avoid or Use Alternate Drug.lofexidineMonitor Closely (1)asenapine transdermal and lofexidine both increase QTc interval. Use Caution/Monitor.loperamideSerious - Use Alternative (1)asenapine transdermal and loperamide both increase QTc interval. Avoid or Use Alternate Drug.lopinavirSerious - Use Alternative (1)asenapine transdermal and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.loratadineMonitor Closely (1)asenapine transdermal and loratadine both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)asenapine transdermal and lorazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)asenapine transdermal and loxapine both increase sedation. Use Caution/Monitor.lumateperoneMonitor Closely (1)asenapine transdermal and lumateperone both increase sedation. Use Caution/Monitor.lurasidoneMonitor Closely (1)asenapine transdermal and lurasidone both increase sedation. Use Caution/Monitor.macimorelinSerious - Use Alternative (1)asenapine transdermal and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.maprotilineMonitor Closely (1)asenapine transdermal and maprotiline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.meclizineMonitor Closely (1)asenapine transdermal and meclizine both increase sedation. Use Caution/Monitor.mefloquineSerious - Use Alternative (1)asenapine transdermal and mefloquine both increase QTc interval. Avoid or Use Alternate Drug.meperidineMonitor Closely (1)asenapine transdermal and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)asenapine transdermal and meprobamate both increase sedation. Use Caution/Monitor.metaxaloneMonitor Closely (1)asenapine transdermal and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)asenapine transdermal and methadone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and methadone both increase QTc interval. Avoid or Use Alternate Drug.methocarbamolMonitor Closely (1)asenapine transdermal and methocarbamol both increase sedation. Use Caution/Monitor.methohexitalMonitor Closely (1)asenapine transdermal and methohexital both increase sedation. Use Caution/Monitor.methsuximideMonitor Closely (1)asenapine transdermal and methsuximide both increase sedation. Use Caution/Monitor.metoclopramide intranasalSerious - Use Alternative (1)asenapine transdermal increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.midazolamMonitor Closely (1)asenapine transdermal and midazolam both increase sedation. Use Caution/Monitor.midostaurinSerious - Use Alternative (1)asenapine transdermal and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mifepristoneSerious - Use Alternative (1)asenapine transdermal and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.mirtazapineMonitor Closely (1)asenapine transdermal and mirtazapine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and mirtazapine both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibSerious - Use Alternative (1)mobocertinib and asenapine transdermal both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.molindoneMonitor Closely (1)asenapine transdermal and molindone both increase sedation. Use Caution/Monitor.morphineSerious - Use Alternative (1)asenapine transdermal and morphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatemoxifloxacinSerious - Use Alternative (1)asenapine transdermal and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nalbuphineMonitor Closely (1)asenapine transdermal and nalbuphine both increase sedation. Use Caution/Monitor.nilotinibSerious - Use Alternative (1)asenapine transdermal and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.nitrous oxideMonitor Closely (1)asenapine transdermal and nitrous oxide both increase sedation. Use Caution/Monitor.nortriptylineMonitor Closely (2)asenapine transdermal and nortriptyline both increase QTc interval. Use Caution/Monitor. asenapine transdermal and nortriptyline both increase sedation. Use Caution/Monitor.octreotideSerious - Use Alternative (1)asenapine transdermal and octreotide both increase QTc interval. Avoid or Use Alternate Drug.ofloxacinSerious - Use Alternative (1)asenapine transdermal and ofloxacin both increase QTc interval. Avoid or Use Alternate Drug.olanzapineMonitor Closely (2)asenapine transdermal and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances asenapine transdermal and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (2)oliceridine, asenapine transdermal. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. asenapine transdermal and oliceridine both increase sedation. Use Caution/Monitor.olodaterol inhaledMonitor Closely (1)asenapine transdermal and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmiasolopatadine intranasalSerious - Use Alternative (1)asenapine transdermal and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronSerious - Use Alternative (1)asenapine transdermal and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.opicaponeMonitor Closely (1)asenapine transdermal and opicapone both increase sedation. Use Caution/Monitor.opium tinctureMonitor Closely (1)asenapine transdermal and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineMonitor Closely (1)asenapine transdermal and orphenadrine both increase sedation. Use Caution/Monitor.osilodrostatMonitor Closely (1)asenapine transdermal and osilodrostat both increase QTc interval. Use Caution/Monitor. Dose dependent QT prolongation - avoid drugs known to prolong the QT intervalosimertinibMonitor Closely (1)asenapine transdermal and osimertinib both increase QTc interval. Use Caution/Monitor.oxaliplatinSerious - Use Alternative (1)asenapine transdermal and oxaliplatin both increase QTc interval. Avoid