Caution/Monitor.cyclizineMonitor Closely (1)cyclizine and oxazepam both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)oxazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and oxazepam both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)oxazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)oxazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluraneMonitor Closely (1)desflurane and oxazepam both increase sedation. Use Caution/Monitor.desipramineMonitor Closely (1)oxazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)oxazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and oxazepam both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)oxazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)oxazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)oxazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)oxazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)oxazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)oxazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and oxazepam both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionMonitor Closely (1)oxazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and oxazepam both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)oxazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and oxazepam both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and oxazepam both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)oxazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)oxazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineMonitor Closely (1)oxazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)oxazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)oxazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)oxazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)oxazepam and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)oxazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)oxazepam and droperidol both increase sedation. Use Caution/Monitor.ephedrineMonitor Closely (1)oxazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)oxazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)oxazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)esketamine intranasal, oxazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamMonitor Closely (1)estazolam and oxazepam both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (1)oxazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and oxazepam both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)oxazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fenfluramineMonitor Closely (1)oxazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fleroxacinMinor (1)fleroxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.flibanserinMonitor Closely (1)oxazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineMonitor Closely (1)oxazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam and oxazepam both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)oxazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentinMonitor Closely (1)gabapentin, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)oxazepam and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinMinor (1)gemifloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.green teaMinor (1)green tea decreases effects of oxazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.haloperidolMonitor Closely (1)oxazepam and haloperidol both increase sedation. Use Caution/Monitor.hyaluronidaseMonitor Closely (1)hyaluronidase, oxazepam. Other (see comment). Use Caution/Monitor. Comment: Drug combination has been found to be incompatible.hydrocodoneSerious - Use Alternative (1)hydrocodone, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)oxazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and oxazepam both increase sedation. Use Caution/Monitor.iloperidoneMonitor Closely (1)oxazepam and iloperidone both increase sedation. Use Caution/Monitor.imipramineMonitor Closely (1)oxazepam and imipramine both increase sedation. Use Caution/Monitor.isoproterenolMonitor Closely (1)oxazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineMonitor Closely (1)ketamine and oxazepam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicMonitor Closely (1)oxazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.labetalolMinor (1)labetalol increases effects of oxazepam by decreasing metabolism. Minor/Significance Unknown.lasmiditanMonitor Closely (1)lasmiditan, oxazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantMonitor Closely (1)lemborexant, oxazepam. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.levalbuterolMonitor Closely (1)oxazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levofloxacinMinor (1)levofloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.levorphanolMonitor Closely (1)oxazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)oxazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineMonitor Closely (1)oxazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineMonitor Closely (1)oxazepam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamMonitor Closely (1)loprazolam and oxazepam both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam and oxazepam both increase sedation. Use Caution/Monitor.lormetazepamMonitor Closely (1)lormetazepam and oxazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)oxazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)oxazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, oxazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineMonitor Closely (1)oxazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)oxazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninMonitor Closely (1)oxazepam and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)oxazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)oxazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)oxazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)oxazepam and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)oxazepam and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)oxazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)oxazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)oxazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metoclopramide intranasalSerious - Use Alternative (1)oxazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.metoprololMinor (1)metoprolol increases effects of oxazepam by decreasing metabolism. Minor/Significance Unknown.midazolamMonitor Closely (1)midazolam and oxazepam both increase sedation. Use Caution/Monitor.midazolam intranasalMonitor Closely (1)midazolam intranasal, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineMonitor Closely (1)oxazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineMonitor Closely (1)oxazepam and mirtazapine both increase sedation. Use Caution/Monitor.modafinilMonitor Closely (1)oxazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineMonitor Closely (1)oxazepam and morphine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)oxazepam and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinMinor (1)moxifloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.moxonidineMonitor Closely (1)oxazepam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)oxazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphineMonitor Closely (1)oxazepam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrineMonitor Closely (1)oxazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineMonitor Closely (1)oxazepam and nortriptyline both increase sedation. Use Caution/Monitor.ofloxacinMinor (1)ofloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.olanzapineMonitor Closely (1)oxazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (1)oliceridine, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olopatadine intranasalSerious - Use Alternative (1)oxazepam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. opium tinctureMonitor Closely (1)oxazepam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineMonitor Closely (1)oxazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxycodoneMonitor Closely (1)oxazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneMonitor Closely (1)oxazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneMonitor Closely (1)oxazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumMonitor Closely (1)oxazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverineMonitor Closely (1)oxazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocineMonitor Closely (1)oxazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and oxazepam both increase sedation. Use Caution/Monitor.perampanelMonitor Closely (1)perampanel and oxazepam both increase sedation. Use Caution/Monitor.perphenazineMonitor Closely (1)oxazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineMonitor Closely (1)oxazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (1)phenobarbital and oxazepam both increase sedation. Use Caution/Monitor.phentermineMonitor Closely (1)oxazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (1)oxazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (1)oxazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineMonitor Closely (1)oxazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozideMonitor Closely (1)oxazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)oxazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinMonitor Closely (1)pregabalin, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneMonitor Closely (1)primidone and oxazepam both increase sedation. Use Caution/Monitor.prochlorperazineMonitor Closely (1)oxazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineMonitor Closely (1)promethazine and oxazepam both increase sedation. Use Caution/Monitor.propofolMonitor Closely (1)propofol and oxazepam both increase sedation. Use Caution/Monitor.propranololMinor (1)propranolol increases effects of oxazepam by decreasing metabolism. Minor/Significance Unknown.propylhexedrineMonitor Closely (1)oxazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)oxazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamMonitor Closely (1)oxazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapineMonitor Closely (1)oxazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonMonitor Closely (1)oxazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamMonitor Closely (1)remimazolam, oxazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.rifabutinMinor (1)rifabutin decreases levels of oxazepam by increasing metabolism. Minor/Significance Unknown.risperidoneMonitor Closely (1)oxazepam and risperidone both increase sedation. Use Caution/Monitor.sageMinor (1)oxazepam and sage both increase sedation. Minor/Significance Unknown.salmeterolMonitor Closely (1)oxazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapMonitor Closely (1)oxazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalMonitor Closely (1)secobarbital and oxazepam both increase sedation. Use Caution/Monitor.selinexorSerious - Use Alternative (1)selinexor, oxazepam. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sevofluraneMonitor Closely (1)sevoflurane and oxazepam both increase