effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.thiothixenesolifenacin decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.solifenacin decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.thiothixene increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.solifenacin and thiothixene both increase QTc interval. Use Caution/Monitor.tiotropiumsolifenacin and tiotropium both decrease cholinergic effects/transmission. Use Caution/Monitor.tolterodinesolifenacin and tolterodine both decrease cholinergic effects/transmission. Use Caution/Monitor.topiramatetopiramate will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodonesolifenacin and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.triclabendazolesolifenacin and triclabendazole both increase QTc interval. Use Caution/Monitor.trifluoperazinesolifenacin decreases levels of trifluoperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.solifenacin decreases levels of trifluoperazine by pharmacodynamic antagonism. Use Caution/Monitor.trifluoperazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.solifenacin and trifluoperazine both decrease QTc interval. Use Caution/Monitor.trihexyphenidylsolifenacin and trihexyphenidyl both decrease cholinergic effects/transmission. Use Caution/Monitor. Potential for additive anticholinergic effects.trimipraminesolifenacin and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.solifenacin and trimipramine both increase QTc interval. Use Caution/Monitor.triptorelinsolifenacin and triptorelin both increase QTc interval. Use Caution/Monitor.trospium chloridesolifenacin and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.valbenazinevalbenazine and solifenacin both increase QTc interval. Use Caution/Monitor.vardenafilsolifenacin and vardenafil both increase QTc interval. Use Caution/Monitor.vecuroniumsolifenacin and vecuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.venlafaxinesolifenacin and venlafaxine both decrease QTc interval. Use Caution/Monitor.verapamilverapamil will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.voclosporinvoclosporin, solifenacin. Either increases effects of the other by QTc interval. Use Caution/Monitor.voriconazolevoriconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.vorinostatsolifenacin and vorinostat both increase QTc interval. Use Caution/Monitor.vorinostat and solifenacin both increase QTc interval. Use Caution/Monitor.zafirlukastzafirlukast will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ziprasidonesolifenacin decreases levels of ziprasidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.solifenacin decreases levels of ziprasidone by pharmacodynamic antagonism. Use Caution/Monitor.ziprasidone increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.zotepinesolifenacin decreases levels of zotepine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.solifenacin decreases levels of zotepine by pharmacodynamic antagonism. Use Caution/Monitor.Minor (10)acetazolamideacetazolamide will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anastrozoleanastrozole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.azithromycinazithromycin increases toxicity of solifenacin by QTc interval. Minor/Significance Unknown.chloroquinechloroquine increases toxicity of solifenacin by QTc interval. Minor/Significance Unknown.cyclophosphamidecyclophosphamide will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.dimenhydrinatedimenhydrinate increases toxicity of solifenacin by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.donepezildonepezil decreases effects of solifenacin by pharmacodynamic antagonism. Minor/Significance Unknown.galantaminegalantamine decreases effects of solifenacin by pharmacodynamic antagonism. Minor/Significance Unknown.larotrectiniblarotrectinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.levodopasolifenacin, levodopa. Other (see comment). Minor/Significance Unknown. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .abametapirSerious - Use Alternative (1)abametapir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.abobotulinumtoxinAMonitor Closely (1)abobotulinumtoxinA increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .acetazolamideMinor (1)acetazolamide will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.aclidiniumMonitor Closely (1)solifenacin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.adagrasibSerious - Use Alternative (1)adagrasib, solifenacin. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolMonitor Closely (1)albuterol and solifenacin both increase QTc interval. Use Caution/Monitor.alfuzosinMonitor Closely (2)solifenacin and alfuzosin both increase QTc interval. Use Caution/Monitor. alfuzosin and solifenacin both increase QTc interval. Use Caution/Monitor.amantadineMonitor Closely (1)solifenacin, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amiodaroneSerious - Use Alternative (1)solifenacin and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideMonitor Closely (1)amisulpride and solifenacin both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.amitriptylineMonitor Closely (2)solifenacin and amitriptyline both increase QTc interval. Use Caution/Monitor. solifenacin and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.amoxapineMonitor Closely (2)solifenacin and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. solifenacin and amoxapine both increase QTc interval. Use Caution/Monitor.anagrelideSerious - Use Alternative (1)solifenacin and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.anastrozoleMinor (1)anastrozole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anticholinergic/sedative combosMonitor Closely (1)anticholinergic/sedative combos and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.apalutamideSerious - Use Alternative (1)apalutamide will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphineMonitor Closely (1)apomorphine and solifenacin both increase QTc interval. Use Caution/Monitor.aprepitantMonitor Closely (1)aprepitant will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.arformoterolMonitor Closely (1)arformoterol and solifenacin both increase QTc interval. Use Caution/Monitor.aripiprazoleMonitor Closely (4)solifenacin decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. solifenacin decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor. aripiprazole increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. aripiprazole and solifenacin both increase QTc interval. Use Caution/Monitor.armodafinilMonitor Closely (1)armodafinil will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.arsenic trioxideSerious - Use Alternative (1)solifenacin and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherSerious - Use Alternative (1)artemether and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineMonitor Closely (1)artemether/lumefantrine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)solifenacin and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapineSerious - Use Alternative (1)solifenacin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalSerious - Use Alternative (1)asenapine transdermal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.atazanavirMonitor Closely (1)atazanavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.atomoxetineMonitor Closely (1)atomoxetine and solifenacin both increase QTc interval. Use Caution/Monitor.atracuriumMonitor Closely (1)atracurium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineMonitor Closely (1)atropine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMMonitor Closely (1)atropine IV/IM and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.azithromycinMinor (1)azithromycin increases toxicity of solifenacin by QTc interval. Minor/Significance Unknown.bedaquilineMonitor Closely (1)solifenacin and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsMonitor Closely (1)belladonna alkaloids and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)belladonna and opium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.benperidolMonitor Closely (3)solifenacin decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. solifenacin decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor. benperidol increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benztropineMonitor Closely (1)benztropine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. bethanecholMonitor Closely (1)bethanechol increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.bosentanMonitor Closely (1)bosentan will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.budesonideMonitor Closely (1)budesonide will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.buprenorphineSerious - Use Alternative (1)solifenacin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalSerious - Use Alternative (1)buprenorphine buccal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantSerious - Use Alternative (1)buprenorphine subdermal implant and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionSerious - Use Alternative (1)buprenorphine, long-acting injection and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.butabarbitalMonitor Closely (1)butabarbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.carbacholMonitor Closely (1)carbachol increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbamazepineSerious - Use Alternative (1)carbamazepine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.cenobamateMonitor Closely (1)cenobamate will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.ceritinibSerious - Use Alternative (2)ceritinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. ceritinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.cevimelineMonitor Closely (1)cevimeline increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloroquineMinor (1)chloroquine increases toxicity of solifenacin by QTc interval. Minor/Significance Unknown.chlorpromazineMonitor Closely (3)solifenacin decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. solifenacin decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor. chlorpromazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.Serious - Use Alternative (1)solifenacin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.cimetidineSerious - Use Alternative (1)cimetidine will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.ciprofloxacinMonitor Closely (1)solifenacin and ciprofloxacin both increase QTc interval. Use Caution/Monitor.cisatracuriumMonitor Closely (1)cisatracurium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.citalopramSerious - Use Alternative (1)citalopram and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinSerious - Use Alternative (2)clarithromycin will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. clarithromycin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineMonitor Closely (2)solifenacin and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. solifenacin and clomipramine both increase QTc interval. Use Caution/Monitor.clozapineMonitor Closely (4)solifenacin decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. solifenacin decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor. clozapine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. clozapine and solifenacin both increase QTc interval. Use Caution/Monitor.cobicistatSerious - Use Alternative (1)cobicistat will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.conivaptanMonitor Closely (1)conivaptan will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.cortisoneMonitor Closely (1)cortisone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.crizotinibMonitor Closely (1)crizotinib increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A.Serious - Use Alternative (1)crizotinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.crofelemerMonitor Closely (1)crofelemer increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.cyclizineMonitor Closely (1)cyclizine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)cyclobenzaprine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclophosphamideMinor (1)cyclophosphamide will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.cyclosporineMonitor Closely (1)cyclosporine will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4