increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazolechlorpromazine and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lefamulinlefamulin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.levodopachlorpromazine decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug.levodopa inhaledchlorpromazine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Phenothiazine/1st generation antipsychotics inhibit dopamine D2 receptors in varying degrees.levoketoconazolechlorpromazine and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lisuridechlorpromazine decreases effects of lisuride by pharmacodynamic antagonism. Contraindicated.lithiumlithium and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.lofepraminechlorpromazine and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.lumefantrinechlorpromazine and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilinechlorpromazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.methyl aminolevulinatechlorpromazine, methyl aminolevulinate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.methyldopachlorpromazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.metoclopramide intranasalchlorpromazine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.chlorpromazine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.metoprololmetoprolol, chlorpromazine. Either increases levels of the other by decreasing metabolism. Contraindicated. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact).mirtazapinemirtazapine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibmobocertinib and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinchlorpromazine and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotinibchlorpromazine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.nortriptylinechlorpromazine and nortriptyline both increase QTc interval. Avoid or Use Alternate Drug.octreotidechlorpromazine and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)chlorpromazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.olanzapineolanzapine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasalchlorpromazine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronchlorpromazine and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.oxaliplatinoxaliplatin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.panobinostatchlorpromazine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.paroxetineparoxetine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.perphenazinechlorpromazine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.pexidartinibchlorpromazine and pexidartinib both increase Other (see comment). Avoid or Use Alternate Drug. Pexidartinib can cause hepatotoxicity. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity.pitolisantchlorpromazine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodponesimod, chlorpromazine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Consult cardiologist if considering treatment. Generally, should not be initiated in patients who are concurrently taking QT prolonging drugs with known arrhythmogenic properties, such as HR-lowering calcium channel blockers (eg, verapamil, diltiazem).pramipexolechlorpromazine decreases effects of pramipexole by pharmacodynamic antagonism. Contraindicated.primaquineprimaquine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.prochlorperazinechlorpromazine and prochlorperazine both increase QTc interval. Avoid or Use Alternate Drug.promazinechlorpromazine and promazine both increase QTc interval. Avoid or Use Alternate Drug.promethazinechlorpromazine and promethazine both increase QTc interval. Avoid or Use Alternate Drug.propafenonepropafenone will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.propranololpropranolol, chlorpromazine. Either increases levels of the other by decreasing metabolism. Contraindicated. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact).protriptylinechlorpromazine and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.quinidinequinidine, chlorpromazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive cardiac effects.ribociclibribociclib increases toxicity of chlorpromazine by QTc interval. Avoid or Use Alternate Drug.ropinirolechlorpromazine decreases effects of ropinirole by pharmacodynamic antagonism. Contraindicated.selinexorselinexor, chlorpromazine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sertralinesertraline and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.sevofluranesevoflurane and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.siponimodsiponimod and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.sodium oxybatechlorpromazine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.solifenacinsolifenacin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.sunitinibsunitinib and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.tacrolimustacrolimus and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.tetrabenazinetetrabenazine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.thioridazinechlorpromazine and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.trazodonechlorpromazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.tretinoinchlorpromazine, tretinoin. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased phototoxicity.tretinoin topicalchlorpromazine, tretinoin topical. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased phototoxicity.trifluoperazinechlorpromazine and trifluoperazine both increase QTc interval. Avoid or Use Alternate Drug.trimipraminechlorpromazine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.umeclidinium bromide/vilanterol inhaledchlorpromazine increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vandetanibchlorpromazine, vandetanib. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.vemurafenibvemurafenib and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended.vilanterol/fluticasone furoate inhaledchlorpromazine increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vorinostatvorinostat and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.vortioxetinechlorpromazine increases levels of vortioxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Decrease vortioxetine dose by 50% when coadministered with strong CYP2D6 inhibitors.yohimbeyohimbe decreases effects of chlorpromazine by pharmacodynamic antagonism. Contraindicated.ziprasidonechlorpromazine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (331)abirateroneabiraterone increases levels of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.abobotulinumtoxinAabobotulinumtoxinA increases effects of chlorpromazine by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects.aclidiniumaclidinium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.acrivastineacrivastine and chlorpromazine both increase sedation. Use Caution/Monitor.albiglutidechlorpromazine, albiglutide. Other (see comment). Use Caution/Monitor. Comment: Phenothiazines may increase or decrease glucose levels, monitor therapy closely when these agents are concurrently administered.albuterolchlorpromazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and chlorpromazine both increase QTc interval. Use Caution/Monitor.alfentanilalfentanil and chlorpromazine both increase sedation. Use Caution/Monitor.alfuzosinchlorpromazine and alfuzosin both increase QTc interval. Use Caution/Monitor.alprazolamalprazolam and chlorpromazine both increase sedation. Use Caution/Monitor.amifampridinechlorpromazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.amitriptylinechlorpromazine and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and chlorpromazine both increase sedation. Use Caution/Monitor.amoxapinechlorpromazine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.chlorpromazine and amoxapine both increase sedation. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.anticholinergic/sedative combos decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.apomorphinechlorpromazine and apomorphine both increase sedation. Use Caution/Monitor.arformoterolchlorpromazine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and chlorpromazine both increase QTc interval. Use Caution/Monitor.aripiprazolearipiprazole and chlorpromazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.aripiprazole and chlorpromazine both increase sedation. Use Caution/Monitor.armodafinilchlorpromazine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.artemether/lumefantrineartemether/lumefantrine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapineasenapine and chlorpromazine both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and chlorpromazine both increase sedation. Use Caution/Monitor.atracuriumatracurium decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atracurium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of atracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropineatropine decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of atropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IMchlorpromazine increases effects of atropine IV/IM by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IM decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine IV/IM decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.avapritinibavapritinib and chlorpromazine both increase sedation. Use Caution/Monitor.azelastineazelastine and chlorpromazine both increase sedation. Use Caution/Monitor.azithromycinchlorpromazine and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenbaclofen and chlorpromazine both increase sedation. Use Caution/Monitor.bedaquilinechlorpromazine and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsbelladonna alkaloids decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna alkaloids decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of belladonna alkaloids by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.belladonna and opiumbelladonna and opium and chlorpromazine both increase sedation. Use Caution/Monitor.belladonna and opium decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna and opium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of belladonna and opium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benperidolbenperidol and chlorpromazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.benperidol and chlorpromazine both increase sedation. Use Caution/Monitor.benzphetaminechlorpromazine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazine, benzphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.benztropinechlorpromazine increases effects of benztropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. .bosutinibbosutinib and chlorpromazine both increase QTc interval. Use Caution/Monitor.brexanolonebrexanolone, chlorpromazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolechlorpromazine will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Administer half of the usual brexpiprazole dose when coadministered with strong CYP2D6 inhibitors. If also administered with a strong/moderate CYP3A4 inhibitor, administer a quarter of brexpiprazole