increased adverse effects and toxicity.maprotilineestazolam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaestazolam and marijuana both increase sedation. Use Caution/Monitor.melatoninestazolam and melatonin both increase sedation. Use Caution/Monitor.meperidineestazolam and meperidine both increase sedation. Use Caution/Monitor.meprobamateestazolam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolestazolam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneestazolam and metaxalone both increase sedation. Use Caution/Monitor.methadoneestazolam and methadone both increase sedation. Use Caution/Monitor.methamphetamineestazolam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolestazolam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineestazolam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolamestazolam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineestazolam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineestazolam and mirtazapine both increase sedation. Use Caution/Monitor.modafinilestazolam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineestazolam and morphine both increase sedation. Use Caution/Monitor.motherwortestazolam and motherwort both increase sedation. Use Caution/Monitor.moxonidineestazolam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneestazolam and nabilone both increase sedation. Use Caution/Monitor.nalbuphineestazolam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrineestazolam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineestazolam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapineestazolam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tinctureestazolam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineestazolam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamestazolam and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneestazolam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneestazolam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneestazolam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumestazolam and papaveretum both increase sedation. Use Caution/Monitor.papaverineestazolam and papaverine both increase sedation. Use Caution/Monitor.pentazocineestazolam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and estazolam both increase sedation. Use Caution/Monitor.perphenazineestazolam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineestazolam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and estazolam both increase sedation. Use Caution/Monitor.phentermineestazolam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineestazolam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POestazolam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineestazolam and pholcodine both increase sedation. Use Caution/Monitor.pimozideestazolam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolestazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinpregabalin, estazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and estazolam both increase sedation. Use Caution/Monitor.prochlorperazineestazolam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and estazolam both increase sedation. Use Caution/Monitor.propofolpropofol and estazolam both increase sedation. Use Caution/Monitor.propylhexedrineestazolam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineestazolam and protriptyline both increase sedation. Use Caution/Monitor.quazepamestazolam and quazepam both increase sedation. Use Caution/Monitor.quetiapineestazolam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonestazolam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, estazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.risperidoneestazolam and risperidone both increase sedation. Use Caution/Monitor.salmeterolestazolam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapestazolam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and estazolam both increase sedation. Use Caution/Monitor.sevofluranesevoflurane and estazolam both increase sedation. Use Caution/Monitor.shepherd's purseestazolam and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, estazolam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanilestazolam and sufentanil both increase sedation. Use Caution/Monitor.tapentadolestazolam and tapentadol both increase sedation. Use Caution/Monitor.temazepamestazolam and temazepam both increase sedation. Use Caution/Monitor.terbutalineestazolam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineestazolam and thioridazine both increase sedation. Use Caution/Monitor.thiothixeneestazolam and thiothixene both increase sedation. Use Caution/Monitor.topiramateestazolam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolestazolam and tramadol both increase sedation. Use Caution/Monitor.trazodoneestazolam and trazodone both increase sedation. Use Caution/Monitor.triazolamestazolam and triazolam both increase sedation. Use Caution/Monitor.triclofosestazolam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazineestazolam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipramineestazolam and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and estazolam both increase sedation. Use Caution/Monitor.xylometazolineestazolam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbineestazolam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotideestazolam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneestazolam and ziprasidone both increase sedation. Use Caution/Monitor.zotepineestazolam and zotepine both increase sedation. Use Caution/Monitor.Minor (14)brimonidinebrimonidine increases effects of estazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.ciprofloxacinciprofloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.esomeprazoleesomeprazole will increase the level or effect of estazolam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.eucalyptusestazolam and eucalyptus both increase sedation. Minor/Significance Unknown.fleroxacinfleroxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.levofloxacinlevofloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.omeprazoleomeprazole increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of estazolam by increasing metabolism. Minor/Significance Unknown.sageestazolam and sage both increase sedation. Minor/Significance Unknown.vinpocetineestazolam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).zolpidemzolpidem, estazolam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.acrivastineMonitor Closely (1)acrivastine and estazolam both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)estazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)estazolam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and estazolam both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and estazolam both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)estazolam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and estazolam both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)estazolam and amoxapine both increase sedation. Use Caution/Monitor.apomorphineMonitor Closely (1)estazolam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)estazolam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)estazolam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)estazolam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and estazolam both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and estazolam both increase sedation. Use Caution/Monitor.avapritinibMonitor Closely (1)avapritinib and estazolam both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and estazolam both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)estazolam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)estazolam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)estazolam and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)estazolam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, estazolam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and estazolam both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and estazolam both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of estazolam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and estazolam both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and estazolam both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)estazolam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)estazolam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantSerious - Use Alternative (1)buprenorphine subdermal implant and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionMonitor Closely (1)estazolam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.Serious - Use Alternative (1)buprenorphine, long-acting injection and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)butabarbital and estazolam both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and estazolam both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)estazolam and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)estazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesContraindicated (1)estazolam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.carbinoxamineMonitor Closely (1)carbinoxamine and estazolam both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)estazolam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, estazolam. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateMonitor Closely (1)estazolam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and estazolam both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and estazolam both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)estazolam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)estazolam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and estazolam both increase sedation. Use Caution/Monitor.ciprofloxacinMinor (1)ciprofloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.clemastineMonitor Closely (1)clemastine and estazolam both increase sedation. Use Caution/Monitor.clomipramineMonitor Closely (1)estazolam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and estazolam both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateMonitor Closely (1)clorazepate and estazolam both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)estazolam and clozapine both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)estazolam and codeine both increase sedation. Use Caution/Monitor.cyclizineMonitor Closely (1)cyclizine and estazolam both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)estazolam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and estazolam both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)estazolam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)estazolam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluraneMonitor Closely (1)desflurane and estazolam both increase sedation. Use Caution/Monitor.desipramineMonitor Closely (1)estazolam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)estazolam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and estazolam both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)estazolam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)estazolam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)estazolam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)estazolam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)estazolam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)estazolam and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and estazolam both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionMonitor Closely (1)estazolam increases and