decreases effects of travelers diarrhea and cholera vaccine inactivated by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.trimipraminehydroxychloroquine sulfate and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.typhoid polysaccharide vaccinehydroxychloroquine sulfate decreases effects of typhoid polysaccharide vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.typhoid vaccine livehydroxychloroquine sulfate decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.ustekinumabhydroxychloroquine sulfate and ustekinumab both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.vandetanibhydroxychloroquine sulfate and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.vardenafilhydroxychloroquine sulfate and vardenafil both increase QTc interval. Avoid or Use Alternate Drug.varicella virus vaccine livehydroxychloroquine sulfate decreases effects of varicella virus vaccine live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.vemurafenibhydroxychloroquine sulfate and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaledhydroxychloroquine sulfate and vilanterol/fluticasone furoate inhaled both increase QTc interval. Avoid or Use Alternate Drug.voriconazolehydroxychloroquine sulfate and voriconazole both increase QTc interval. Avoid or Use Alternate Drug.vorinostathydroxychloroquine sulfate and vorinostat both increase QTc interval. Avoid or Use Alternate Drug.ziprasidonehydroxychloroquine sulfate and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.zoster vaccine livehydroxychloroquine sulfate decreases effects of zoster vaccine live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.Monitor Closely (27)astragalushydroxychloroquine sulfate increases and astragalus decreases immunosuppressive effects; risk of infection. Effect of interaction is not clear, use caution. Use Caution/Monitor.bupivacaine implanthydroxychloroquine sulfate, bupivacaine implant. Either increases effects of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.cholera vaccinehydroxychloroquine sulfate decreases effects of cholera vaccine by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than physiologic doses), may reduce the immune response to cholera vaccine.cyclosporinehydroxychloroquine sulfate will increase the level or effect of cyclosporine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.dengue vaccinehydroxychloroquine sulfate decreases effects of dengue vaccine by immunosuppressive effects; risk of infection. Use Caution/Monitor. Immunosuppressive therapies (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, corticosteroids [greater than physiologic doses]) may reduce immune response to dengue vaccine.denosumabhydroxychloroquine sulfate, denosumab. Other (see comment). Use Caution/Monitor. Comment: Caution should be taken in patients on concomitant immunosuppressants or with impaired immune systems because of increased risk for serious infections.deutetrabenazinehydroxychloroquine sulfate and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).echinaceahydroxychloroquine sulfate increases and echinacea decreases immunosuppressive effects; risk of infection. Effect of interaction is not clear, use caution. Use Caution/Monitor.fostemsavirhydroxychloroquine sulfate and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. influenza virus vaccine trivalent, recombinanthydroxychloroquine sulfate decreases effects of influenza virus vaccine trivalent, recombinant by pharmacodynamic antagonism. Use Caution/Monitor. Immune response to vaccine may be decreased in immunocompromised individuals.isavuconazonium sulfatehydroxychloroquine sulfate and isavuconazonium sulfate both decrease immunosuppressive effects; risk of infection. Use Caution/Monitor.maitakehydroxychloroquine sulfate increases and maitake decreases immunosuppressive effects; risk of infection. Effect of interaction is not clear, use caution. Use Caution/Monitor.mercaptopurinehydroxychloroquine sulfate and mercaptopurine both increase immunosuppressive effects; risk of infection. Use Caution/Monitor.methotrexatehydroxychloroquine sulfate decreases levels of methotrexate by unknown mechanism. Use Caution/Monitor. Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. .osilodrostatosilodrostat and hydroxychloroquine sulfate both increase QTc interval. Use Caution/Monitor.hydroxychloroquine sulfate and osilodrostat both increase QTc interval. Use Caution/Monitor.ozanimodozanimod and hydroxychloroquine sulfate both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.ozanimod, hydroxychloroquine sulfate. Either increases effects of the other by immunosuppressive effects; risk of infection. Use Caution/Monitor. Coadministration with immunosuppressive therapies may increase the risk of additive immune effects during therapy and in the weeks following administration. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs in order to avoid unintended additive immunosuppressive effects.ponesimodponesimod and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Caution if coadministered because of additive immunosuppressive effects during such therapy and in the weeks following administration. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs to avoid unintended additive immunosuppressive effects.selpercatinibselpercatinib increases toxicity of hydroxychloroquine sulfate by QTc interval. Use Caution/Monitor.siponimodsiponimod and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Caution if coadministered because of additive immunosuppressive effects during such therapy and in the weeks following administration. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs to avoid unintended additive immunosuppressive effects.sipuleucel-Thydroxychloroquine sulfate decreases effects of sipuleucel-T by pharmacodynamic antagonism. Modify Therapy/Monitor Closely.sodium sulfate/?magnesium sulfate/potassium chloridesodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of hydroxychloroquine sulfate by QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias. .sodium sulfate/potassium sulfate/magnesium sulfatesodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of hydroxychloroquine sulfate by QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias. .tobramycin inhaledtobramycin inhaled and hydroxychloroquine sulfate both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicityublituximabublituximab and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Owing to potential additive immunosuppressive effects, consider duration of effect and mechanism of action of these therapies if coadministeredvalbenazinevalbenazine and hydroxychloroquine sulfate both increase QTc interval. Use Caution/Monitor.voclosporinvoclosporin, hydroxychloroquine sulfate. Either increases effects of the other by QTc interval. Use Caution/Monitor.zoster vaccine recombinanthydroxychloroquine sulfate decreases effects of zoster vaccine recombinant by pharmacodynamic antagonism. Use Caution/Monitor. Immunosuppressive therapies may reduce the effectiveness of zoster vaccine recombinant.Minor (3)chloroquinechloroquine increases toxicity of hydroxychloroquine sulfate by QTc interval. Minor/Significance Unknown.praziquantelhydroxychloroquine sulfate increases levels of praziquantel by unspecified interaction mechanism. Minor/Significance Unknown.yellow fever vaccinehydroxychloroquine sulfate, yellow fever vaccine. Other (see comment). Minor/Significance Unknown. Comment: The prescribing information states: "although chloroquine inhibits replication of yellow fever vaccine in vitro, it does not appear to adversely affect antibody responses to yellow fever vaccine among persons receiving chloroquine" .adagrasibSerious - Use Alternative (1)adagrasib, hydroxychloroquine sulfate. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.adalimumabSerious - Use Alternative (1)adalimumab and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.albuterolSerious - Use Alternative (1)albuterol and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.alefaceptSerious - Use Alternative (1)alefacept and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.alfuzosinSerious - Use Alternative (2)hydroxychloroquine sulfate and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. alfuzosin and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.amiodaroneSerious - Use Alternative (1)hydroxychloroquine sulfate and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideSerious - Use Alternative (1)amisulpride and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineSerious - Use Alternative (1)hydroxychloroquine sulfate and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amoxapineSerious - Use Alternative (1)hydroxychloroquine sulfate and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.anagrelideSerious - Use Alternative (1)anagrelide and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.anakinraSerious - Use Alternative (1)anakinra and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.anthrax vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of anthrax vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.antithymocyte globulin equineSerious - Use Alternative (1)antithymocyte globulin equine and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.antithymocyte globulin rabbitSerious - Use Alternative (1)antithymocyte globulin rabbit and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.apomorphineSerious - Use Alternative (1)hydroxychloroquine sulfate and apomorphine both increase QTc interval. Avoid or Use Alternate Drug.arformoterolSerious - Use Alternative (1)hydroxychloroquine sulfate and arformoterol both increase QTc interval. Avoid or Use Alternate Drug.aripiprazoleSerious - Use Alternative (1)aripiprazole and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxideSerious - Use Alternative (1)hydroxychloroquine sulfate and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherSerious - Use Alternative (1)artemether and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineSerious - Use Alternative (1)hydroxychloroquine sulfate and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapineSerious - Use Alternative (1)hydroxychloroquine sulfate and asenapine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalSerious - Use Alternative (1)asenapine transdermal and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.astragalusMonitor Closely (1)hydroxychloroquine sulfate increases and astragalus decreases immunosuppressive effects; risk of infection. Effect of interaction is not clear, use caution. Use Caution/Monitor.atomoxetineSerious - Use Alternative (1)atomoxetine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.axicabtagene ciloleucelSerious - Use Alternative (1)hydroxychloroquine sulfate, axicabtagene ciloleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.azathioprineSerious - Use Alternative (1)azathioprine and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.azithromycinSerious - Use Alternative (1)hydroxychloroquine sulfate and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.basiliximabSerious - Use Alternative (1)basiliximab and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.BCG vaccine liveSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of BCG vaccine live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.bedaquilineSerious - Use Alternative (1)hydroxychloroquine sulfate and bedaquiline both increase QTc interval. Avoid or Use Alternate Drug.brexucabtagene autoleucelSerious - Use Alternative (1)hydroxychloroquine sulfate, brexucabtagene autoleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.bupivacaine implantMonitor Closely (1)hydroxychloroquine sulfate, bupivacaine implant. Either increases effects of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.buprenorphineSerious - Use Alternative (1)buprenorphine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalSerious - Use Alternative (1)buprenorphine buccal and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantSerious - Use Alternative (1)buprenorphine subdermal implant and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionSerious - Use Alternative (1)buprenorphine, long-acting injection and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.canakinumabSerious - Use Alternative (1)canakinumab and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.ceritinibSerious - Use Alternative (1)ceritinib and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.chloroquineMinor (1)chloroquine increases toxicity of hydroxychloroquine sulfate by QTc interval. Minor/Significance Unknown.chlorpromazineSerious - Use Alternative (1)hydroxychloroquine sulfate and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.cholera vaccineMonitor Closely (1)hydroxychloroquine sulfate decreases effects of cholera vaccine by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than physiologic doses), may reduce the immune response to cholera vaccine.ciltacabtagene autoleucelSerious - Use Alternative (1)hydroxychloroquine sulfate, ciltacabtagene autoleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.ciprofloxacinSerious - Use Alternative (1)hydroxychloroquine sulfate and ciprofloxacin both increase QTc interval. Avoid or Use Alternate Drug.cisaprideSerious - Use Alternative (1)hydroxychloroquine sulfate increases toxicity of cisapride by QTc interval. Avoid or Use Alternate Drug.citalopramSerious - Use Alternative (1)hydroxychloroquine sulfate and citalopram both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinSerious - Use Alternative (1)hydroxychloroquine sulfate and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clofazimineSerious - Use Alternative (1)hydroxychloroquine sulfate