AdultPediatricDosage Forms & Strengths Lf = limits of flocculation pertussis/diphtheria/tetanus injection for suspension (15.5mcg/2Lf/5Lf)/0.5mL (Adacel) (18.5mcg/2.5Lf/5Lf)/0.5mL (Boostrix) Immunization Boostrix Indicated as active booster immunization against tetanus, diphtheria, and pertussis for individuals aged ≥10 yr 0.5 mL IM Routine booster vaccination First dose: Administer ≥5 yr after the last dose of diphtheria and tetanus toxoids and acellular pertussis (DTaP) series or after a dose of tetanus and diphtheria toxoids adsorbed (Td) May administer an additional dose ≥9 yr after initial Tdap dose Adacel Indicated for active booster immunization against tetanus, diphtheria and pertussis in individuals aged 10 through 64 years 0.5 mL IM Routine booster vaccination First dose: Administer ≥5 yr after last DTaP or Td dose May administer a second dose ≥8 yr after initial Tdap dose Wound management May administer for tetanus prophylaxis for wound management Booster dose may be administered if >5 yr have elapsed since previous receipt of a tetanus toxoid containing vaccine CDC ACIP Recommendations Regardless of the interval since their last tetanus or diphtheria toxoid-containing vaccine, persons aged ≥19 yr who have never received a dose of Tdap should receive 1 dose of Tdap To ensure continued protection against tetanus and diphtheria, booster doses of either Td or Tdap should be administered every 10 yr throughout life (MMWR January 24, 2020 / 69(3);77-83) Immunization During Pregnancy Adacel or Boostrix Indicated to prevent pertussis in infants younger than 2 months by immunizing pregnant females during third trimester of pregnancy Administer a single 0.5-mL dose regardless of vaccination history and time since prior Td or Tdap Dosage Forms & Strengths Lf = limits of flocculation pertussis/diphtheria/tetanus injection for suspension (15.5mcg/2Lf/5Lf)/0.5mL (Adacel) (18.5mcg/2.5Lf/5Lf)/0.5mL (Boostrix) Routine Vaccination Indicated as active booster immunization for prevention of tetanus, diphtheria (not indicated for primary immunization series) Boostrix: 0.5 mL IM; approved for individuals aged ≥10 yr Adacel 0.5 mL IM; approved for individuals aged ≥10 yr Routine booster vaccination First dose: Administer ≥5 yr after the last dose of diphtheria and tetanus toxoids and acellular pertussis (DTaP) series or after a dose of tetanus and diphtheria toxoids adsorbed (Td) May administer a second dose ≥8 yr after the first dose of Tdap Wound management May administer for tetanus prophylaxis for wound management Booster dose may be administered if >5 yr have elapsed since previous receipt of a tetanus toxoid containing vaccine CDC ACIP general recommendations 11-18 years: A single dose of Tdap, preferably at a preventive care visit at age 11-12 years To ensure continued protection against tetanus and diphtheria, 1 booster dose of either Td or Tdap should be administered every 10 yr throughout life (MMWR January 24, 2020 / 69(3);77-83) Catch-up Vaccination ≥7 years who are not fully immunized with DTaP vaccine: Administer a single-dose Tdap vaccine (preferably the first) dose in the catch-up series; if additional doses are needed, use either Td or Tdap vaccine Children 7-10 years who receive a dose of Tdap as part of the catch-up series: Administer an adolescent Tdap vaccine dose at age 11-12 years 11-18 years: Administer booster of Td or Tdap every 10 years ≥19 years who did previously receive dose of Tdap: Administer 1 dose of Tdap; to ensure continued protection against tetanus and diphtheria, booster doses of either Td or Tdap should be administered every 10 yr throughout life Immunization During Pregnancy Administer Tdap vaccine to pregnant adolescents to reduce morbidity and mortality associated with pertussis in infants <2 months The CDC's Advisory Committee on Immunization Practices (ACIP) recommends all pregnant females receive 1 dose of Tdap during each pregnancy ideally between 27 and 36 weeks of gestation regardless of vaccination history and time since prior Td or Tdap Dosing Considerations Inadvertent doses of Tdap vaccine Age 2 months to 6 years If Tdap is administered inadvertently instead of DTaP as any one of the first 3 doses of the tetanus-diphtheria-pertussis vaccination series, do not count Tdap dose and administer replacement dose of DTaP If Tdap is administered inadvertently as fourth or fifth dose in tetanus-diphtheria-pertussis vaccination series, count Tdap dose as valid and do not replace; administer adolescent Tdap dose as recommended when this child is aged 11-12 years Age 7-10 years Children aged 7-10 years who are fully vaccinated: If Tdap is administered inadvertently, do not count Tdap dose as valid Administer adolescent Tdap dose as recommended when child is 11-12 years; however, if Tdap is administered at age 10 years, the Tdap dose may count as the adolescent Tdap dose Interaction CheckerEnter a drug name and tetanus & reduced diphtheria toxoids/ acellular pertussis vaccineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (5)elivaldogene autotemcelelivaldogene autotemcel, tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine. Either decreases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: The safety and effectiveness of vaccination during or following elivaldogene autotemcel treatment have not been studied. Vaccination is not recommended during the 6 weeks preceding myeloablative conditioning, and until hematological recovery following elivaldogene autotemcel treatment. Where feasible, administer childhood vaccinations before myeloablative conditioning. .ixekizumabixekizumab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Prior to initiating ixekizumab, complete all age appropriate immunizations; non-live vaccinations received during treatment with ixekizumab may not elicit an immune response sufficient to prevent disease.secukinumabsecukinumab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Prior to initiating secukinumab, complete all age appropriate immunizations; non-live vaccinations received during treatment with secukinumab may not elicit an immune response sufficient to prevent disease.siponimodsiponimod decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Pause vaccinations beginning 1 week before initiating siponimod and for 4 weeks after stopping treatment. Coadministration with live attenuated vaccines may increase infection risk.teplizumabteplizumab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by Other (see comment). Avoid or Use Alternate Drug. Comment: Administer all age-appropriate vaccinations before starting teplizumab. Inactivated or mRNA vaccines are not recommended within 2 weeks before teplizumab treatment, during treatment, or 6 weeks after completion of treatment.Monitor Closely (6)certolizumab pegolcertolizumab pegol decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by pharmacodynamic antagonism. Use Caution/Monitor.delandistrogene moxeparvovecdelandistrogene moxeparvovec, tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine. Other (see comment). Use Caution/Monitor. Comment: Consider patient vaccination status before initiating corticosteroid regimen required before delandistrogene moxeparvovec administration. If possible, ensure patients are current with all immunizations according to immunization guidelines. Complete vaccinations at least 4 weeks before starting corticosteroid regimen. High-dose or long-term corticosteroids may decrease immungenicity of vaccines.ifosfamideifosfamide decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Coadministration with immunosuppressant therapy reduced efficacy of the vaccine may occur. If possible, complete all age-appropriate vaccinations at least 2 weeks prior to initiation of immunosuppressant therapy. Patients vaccinated <14 days before initiation or during immunosuppressive therapy should be revaccinated at least 3 months after therapy is discontinued. .melphalanmelphalan decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Coadministration with immunosuppressant therapy reduced efficacy of the vaccine may occur. If possible, complete all age-appropriate vaccinations at least 2 weeks prior to initiation of immunosuppressant therapy. Patients vaccinated <14 days before initiation or during immunosuppressive therapy should be revaccinated at least 3 months after therapy is discontinued. .oxaliplatinoxaliplatin decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by passive renal tubular reabsorption due to increased pH. Modify Therapy/Monitor Closely. Coadministration with immunosuppressant therapy reduced efficacy of the vaccine may occur. If possible, complete all age-appropriate vaccinations at least 2 weeks prior to initiation of immunosuppressant therapy. Patients vaccinated <14 days before initiation or during immunosuppressive therapy should be revaccinated at least 3 months after therapy is discontinued. .ublituximabublituximab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Administer all immunizations according to immunization guidelines at least 4 weeks before initiating ublituximab for live or live-attenuated vaccines and, whenever possible, at least 2 weeks before initiating for non-live vaccines. Vaccination with live virus vaccines is not recommended during treatment and until B-cell repletion. Do not administer live or live-attenuated vaccines to infants of mothers exposed to ublituximab during pregnancy, before confirming recovery of B-cell counts as measured by CD19+ B cells.Minor (0)certolizumab pegolMonitor Closely (1)certolizumab pegol decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by pharmacodynamic antagonism. Use Caution/Monitor.delandistrogene moxeparvovecMonitor Closely (1)delandistrogene moxeparvovec, tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine. Other (see comment). Use Caution/Monitor. Comment: Consider patient vaccination status before initiating corticosteroid regimen required before delandistrogene moxeparvovec administration. If possible, ensure patients are current with all immunizations according to immunization guidelines. Complete vaccinations at least 4 weeks before starting corticosteroid regimen. High-dose or long-term corticosteroids may decrease immungenicity of vaccines.elivaldogene autotemcelSerious - Use Alternative (1)elivaldogene autotemcel, tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine. Either decreases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: The safety and effectiveness of vaccination during or following elivaldogene autotemcel treatment have not been studied. Vaccination is not recommended during the 6 weeks preceding myeloablative conditioning, and until hematological recovery following elivaldogene autotemcel treatment. Where feasible, administer childhood vaccinations before myeloablative conditioning. .ifosfamideMonitor Closely (1)ifosfamide decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Coadministration with immunosuppressant therapy reduced efficacy of the vaccine may occur. If possible, complete all age-appropriate vaccinations at least 2 weeks prior to initiation of immunosuppressant therapy. Patients vaccinated <14 days before initiation or during immunosuppressive therapy should be revaccinated at least 3 months after therapy is discontinued. .ixekizumabSerious - Use Alternative (1)ixekizumab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Prior to initiating ixekizumab, complete all age appropriate immunizations; non-live vaccinations received during treatment with ixekizumab may not elicit an immune response sufficient to prevent disease.melphalanMonitor Closely (1)melphalan decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Coadministration with immunosuppressant therapy reduced efficacy of the vaccine may occur. If possible, complete all age-appropriate vaccinations at least 2 weeks prior to initiation of immunosuppressant therapy. Patients vaccinated <14 days before initiation or during immunosuppressive therapy should be revaccinated at least 3 months after therapy is discontinued. .oxaliplatinMonitor Closely (1)oxaliplatin decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by passive renal tubular reabsorption due to increased pH. Modify Therapy/Monitor Closely. Coadministration with immunosuppressant therapy reduced efficacy of the vaccine may occur. If possible, complete all age-appropriate vaccinations at least 2 weeks prior to initiation of immunosuppressant therapy. Patients vaccinated <14 days before initiation or during immunosuppressive therapy should be revaccinated at least 3 months after therapy is discontinued. .secukinumabSerious - Use Alternative (1)secukinumab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Prior to initiating secukinumab, complete all age appropriate immunizations; non-live vaccinations received during treatment with secukinumab may not elicit an immune response sufficient to prevent disease.siponimodSerious - Use Alternative (1)siponimod decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Pause vaccinations beginning 1 week before initiating siponimod and for 4 weeks after stopping treatment. Coadministration with live attenuated vaccines may increase infection risk.teplizumabSerious - Use Alternative (1)teplizumab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by Other (see comment). Avoid or Use Alternate Drug. Comment: Administer all age-appropriate vaccinations before starting teplizumab. Inactivated or mRNA vaccines are not recommended within 2 weeks before teplizumab treatment, during treatment, or 6 weeks after completion of treatment.ublituximabMonitor Closely (1)ublituximab decreases effects of tetanus & reduced diphtheria toxoids/ acellular pertussis vaccine by immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Administer all immunizations according to immunization guidelines at least 4 weeks before initiating ublituximab for live or live-attenuated vaccines and, whenever possible, at least 2