hr Peak plasma concentration: Mometasone, 20-60 pg/mL; formoterol, 22-125 pg/mL Distribution Protein bound: Mometasone, 98-99%; formoterol, 31-38% Vd: Mometasone, 152 L Metabolism Metabolized in liver by CYP3A4 (mometasone); glucuronidation and O-demethylation followed by conjugation (CYP2D6, CYP2C19, CYP2C9, and CYP2A6 involved in O-demethylation) Elimination Half-life: Mometasone, 25 hr; formoterol, 9-11 hr Total body clearance: Mometasone, 12.5 mL/min/kg; formoterol, 217 mL/min/kg Excretion (mometasone): Urine (8%), feces (74%) Excretion (formoterol): Urine (59-62%), feces (32-34%) Oral Inhalation Preparation Priming Prime inhaler before first use or when inhaler is unused for >5 days Release 4 test puffs into air, away from face Remove cap; shake well for 5 sec before each test puff Instructions Check mouthpiece for objects before use Make sure canister is fully inserted Shake well before each use Oral Inhalation Administration For oral inhalation only Remove cap; place middle or index finger on canister top while placing thumb underneath mouthpiece Breathe out fully through your mouth, expelling as much air from lungs as possible; hold inhaler upright, placing the mouthpiece fully into the mouth, closing your lips around it While pushing firmly on canister top, continue breathing in slowly until lungs are full; avoid breathing out Hold breath as comfortably possible, up to 10 sec Remove inhaler from mouth; breathe through nose while keeping lips closed Repeating dose Wait at least 30 seconds prior preceding second puff Shake well prior to use; repeat steps (see under Oral Inhalation Administration) Replace the cap after use When finished administering 2 puffs, rinse mouth out with water (do not swallow water) Cleaning Wash and dry mouthpiece at least weekly When mouthpiece becomes blocked, wash mouthpiece thoroughly Storage Store at room temperature 20-25°C (68-77°F); excursions permitted to 15-30°C (59-86°F) No images available for this drug. No images available for this drug.A Patient Handout is not currently available for this monograph.Print FormularyPatient DiscountsAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.Create Your List of PlansAdding plans allows you to:View the formulary and any restrictions for each plan.Manage and view all your plans together – even plans in different states.Compare formulary status to other drugs in the same class.Access your plan list on any device – mobile or desktop. The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. View explanations for tiers and restrictions Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. 2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs. 3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs. 4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. NC NOT COVERED – Drugs that are not covered by the plan. Code Definition PA Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. 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