(2)amobarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. amobarbital and trazodone both increase sedation. Use Caution/Monitor.Minor (1)amobarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.amoxapineMonitor Closely (2)amoxapine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor. amoxapine and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug. trazodone and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.anagrelideSerious - Use Alternative (1)anagrelide and trazodone both increase QTc interval. Avoid or Use Alternate Drug.anastrozoleMinor (1)anastrozole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anticholinergic/sedative combosMinor (1)anticholinergic/sedative combos and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.apalutamideSerious - Use Alternative (1)apalutamide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphineMonitor Closely (1)trazodone and apomorphine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)apomorphine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.aprepitantMonitor Closely (1)aprepitant will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.arformoterolMonitor Closely (2)trazodone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and trazodone both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)trazodone, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.aripiprazoleMonitor Closely (1)aripiprazole and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)aripiprazole and trazodone both increase QTc interval. Avoid or Use Alternate Drug.armodafinilMonitor Closely (2)armodafinil will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. trazodone increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)trazodone will decrease the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown.arsenic trioxideContraindicated (1)trazodone and arsenic trioxide both increase QTc interval. Contraindicated.artemetherSerious - Use Alternative (1)artemether and trazodone both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineMonitor Closely (1)artemether/lumefantrine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Serious - Use Alternative (2)trazodone and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug. artemether/lumefantrine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.asenapineMonitor Closely (1)asenapine and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalMonitor Closely (1)asenapine transdermal and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.aspirinMonitor Closely (1)trazodone, aspirin. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.aspirin rectalMonitor Closely (1)trazodone, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.aspirin/citric acid/sodium bicarbonateMonitor Closely (1)trazodone, aspirin/citric acid/sodium bicarbonate. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.atazanavirMonitor Closely (2)atazanavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. atazanavir increases levels of trazodone by unspecified interaction mechanism. Use Caution/Monitor.atogepantMonitor Closely (1)trazodone will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.atomoxetineSerious - Use Alternative (1)atomoxetine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.atorvastatinMonitor Closely (1)trazodone will decrease the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.Minor (1)trazodone increases levels of atorvastatin by unspecified interaction mechanism. Minor/Significance Unknown.atracuriumMonitor Closely (1)atracurium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineMinor (2)atropine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown. trazodone increases levels of atropine by unknown mechanism. Minor/Significance Unknown.atropine IV/IMMonitor Closely (1)atropine IV/IM and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.Minor (1)trazodone increases levels of atropine IV/IM by unknown mechanism. Minor/Significance Unknown.avapritinibMonitor Closely (2)trazodone will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. avapritinib and trazodone both increase sedation. Use Caution/Monitor.axitinibMonitor Closely (1)trazodone increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and trazodone both increase sedation. Use Caution/Monitor.azithromycinMonitor Closely (1)trazodone and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenMonitor Closely (1)baclofen and trazodone both increase sedation. Use Caution/Monitor.bazedoxifene/conjugated estrogensMonitor Closely (1)trazodone will decrease the level or effect of bazedoxifene/conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.Minor (1)bazedoxifene/conjugated estrogens, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.bedaquilineSerious - Use Alternative (1)bedaquiline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.belladonna alkaloidsMinor (1)belladonna alkaloids and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.belladonna and opiumMonitor Closely (2)belladonna and opium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor. belladonna and opium and trazodone both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)benperidol and trazodone both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenMonitor Closely (2)benzhydrocodone/acetaminophen, trazodone. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. benzhydrocodone/acetaminophen and trazodone both increase sedation. Use Caution/Monitor.benzphetamineMonitor Closely (1)trazodone increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)trazodone, benzphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.benztropineMinor (1)benztropine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.bethanecholMinor (1)bethanechol increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.bosentanSerious - Use Alternative (1)bosentan will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.brexpiprazoleMonitor Closely (2)trazodone will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor. brexpiprazole and trazodone both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and trazodone both increase sedation. Use Caution/Monitor.Minor (1)trazodone decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.brivaracetamMonitor Closely (1)brivaracetam and trazodone both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and trazodone both increase sedation. Use Caution/Monitor.budesonideMonitor Closely (2)budesonide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. trazodone will decrease the level or effect of budesonide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.bumetanideMinor (1)bumetanide, trazodone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Possible additive hyponatremia.bupivacaine implantMonitor Closely (1)trazodone, bupivacaine implant. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.buprenorphineMonitor Closely (1)buprenorphine and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalMonitor Closely (1)buprenorphine buccal and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantMonitor Closely (2)trazodone, buprenorphine subdermal implant. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected. buprenorphine subdermal implant and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine subdermal implant and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalMonitor Closely (1)buprenorphine transdermal and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine transdermal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionMonitor Closely (2)trazodone, buprenorphine, long-acting injection. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected. buprenorphine, long-acting injection and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine, long-acting injection and trazodone both increase QTc interval. Avoid or Use Alternate Drug.bupropionSerious - Use Alternative (1)trazodone increases toxicity of bupropion by unspecified interaction mechanism. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible.buspironeSerious - Use Alternative (1)trazodone and buspirone both increase serotonin levels. Avoid or Use Alternate Drug.butabarbitalMonitor Closely (2)butabarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. butabarbital and trazodone both increase sedation. Use Caution/Monitor.Minor (1)butabarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.butalbitalMonitor Closely (2)butalbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. butalbital and trazodone both increase sedation. Use Caution/Monitor.Minor (1)butalbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.butorphanolMonitor Closely (1)butorphanol and trazodone both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)trazodone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)trazodone, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carbacholMinor (1)carbachol increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.carbamazepineMonitor Closely (2)trazodone will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor plasma levels when used concomitantly carbamazepine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)carbamazepine decreases levels of trazodone by increasing metabolism. Minor/Significance Unknown.carbinoxamineMonitor Closely (1)carbinoxamine and trazodone both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)carisoprodol and trazodone both increase sedation. Use Caution/Monitor.celandineMinor (1)celandine decreases effects of trazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.celecoxibMonitor Closely (1)trazodone, celecoxib. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.ceritinibSerious - Use Alternative (2)ceritinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug. ceritinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.cevimelineMinor (1)cevimeline increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.chloral hydrateMonitor Closely (1)chloral hydrate and trazodone both increase sedation. Use Caution/Monitor.chloramphenicolSerious - Use Alternative (1)chloramphenicol will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and trazodone both increase sedation. Use Caution/Monitor.chloroquineSerious - Use Alternative (1)chloroquine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.chlorpheniramineMonitor Closely (1)chlorpheniramine and trazodone both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)chlorpromazine and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)trazodone, chlorpromazine. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects. trazodone, chlorpromazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.chlorpropamideMinor (1)trazodone increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown.chlorzoxazoneMonitor Closely (1)chlorzoxazone and