AdultPediatricGeriatricDosage Forms & Strengths tablet: Schedule IV 1mg 2mg Insomnia 1-2 mg PO qHS Hepatic Impairment Use caution; dose adjustment may be necessarySafety and efficacy not establishedInitial dose: 0.5 mg PO qDay in small elderly patients; healthy patients may receive 1 mgInteraction CheckerEnter a drug name and estazolamNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (3)calcium/magnesium/potassium/sodium oxybatesestazolam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.itraconazoleitraconazole will increase the level or effect of estazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.sodium oxybateestazolam, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.Serious - Use Alternative (15)benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzhydrocodone/acetaminophen and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine subdermal implantbuprenorphine subdermal implant and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalbuprenorphine transdermal and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionbuprenorphine, long-acting injection and estazolam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanylfentanyl, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalfentanyl intranasal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.hydrocodonehydrocodone, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.lemborexantlemborexant, estazolam. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.metoclopramide intranasalestazolam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olopatadine intranasalestazolam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. selinexorselinexor, estazolam. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sufentanil SLsufentanil SL, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.valerianvalerian and estazolam both increase sedation. Avoid or Use Alternate Drug.Monitor Closely (195)acrivastineacrivastine and estazolam both increase sedation. Use Caution/Monitor.albuterolestazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilestazolam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamalprazolam and estazolam both increase sedation. Use Caution/Monitor.amisulprideamisulpride and estazolam both increase sedation. Use Caution/Monitor.amitriptylineestazolam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and estazolam both increase sedation. Use Caution/Monitor.amoxapineestazolam and amoxapine both increase sedation. Use Caution/Monitor.apomorphineestazolam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolestazolam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleestazolam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilestazolam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineasenapine and estazolam both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and estazolam both increase sedation. Use Caution/Monitor.avapritinibavapritinib and estazolam both increase sedation. Use Caution/Monitor.azelastineazelastine and estazolam both increase sedation. Use Caution/Monitor.baclofenestazolam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumestazolam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolestazolam and benperidol both increase sedation. Use Caution/Monitor.benzphetamineestazolam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanolonebrexanolone, estazolam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and estazolam both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and estazolam both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and estazolam both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and estazolam both increase sedation. Use Caution/Monitor.buprenorphineestazolam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalestazolam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionestazolam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.butabarbitalbutabarbital and estazolam both increase sedation. Use Caution/Monitor.butalbitalbutalbital and estazolam both increase sedation. Use Caution/Monitor.butorphanolestazolam and butorphanol both increase sedation. Use Caution/Monitor.caffeineestazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and estazolam both increase sedation. Use Caution/Monitor.carisoprodolestazolam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamatecenobamate, estazolam. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateestazolam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and estazolam both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and estazolam both increase sedation. Use Caution/Monitor.chlorpromazineestazolam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneestazolam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizinecinnarizine and estazolam both increase sedation. Use Caution/Monitor.clemastineclemastine and estazolam both increase sedation. Use Caution/Monitor.clomipramineestazolam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and estazolam both increase sedation. Use Caution/Monitor.clonidineclonidine, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateclorazepate and estazolam both increase sedation. Use Caution/Monitor.clozapineestazolam and clozapine both increase sedation. Use Caution/Monitor.codeineestazolam and codeine both increase sedation. Use Caution/Monitor.cyclizinecyclizine and estazolam both increase sedation. Use Caution/Monitor.cyclobenzaprineestazolam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and estazolam both increase sedation. Use Caution/Monitor.dantroleneestazolam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantestazolam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluranedesflurane and estazolam both increase sedation. Use Caution/Monitor.desipramineestazolam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineestazolam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and estazolam both increase sedation. Use Caution/Monitor.dexfenfluramineestazolam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineestazolam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateestazolam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineestazolam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideestazolam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineestazolam and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiazepam and estazolam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionestazolam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and estazolam both increase sedation. Use Caution/Monitor.difenoxin hclestazolam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and estazolam both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and estazolam both increase sedation. Use Caution/Monitor.diphenoxylate hclestazolam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneestazolam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineestazolam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineestazolam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineestazolam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinestazolam and dosulepin both increase sedation. Use Caution/Monitor.doxepinestazolam and doxepin both increase sedation. Use Caution/Monitor.doxylamineestazolam and doxylamine both increase sedation. Use Caution/Monitor.droperidolestazolam and droperidol both increase sedation. Use Caution/Monitor.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of estazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.ephedrineestazolam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineestazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicestazolam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, estazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.ethanolestazolam and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and estazolam both increase sedation. Use Caution/Monitor.fenfluramineestazolam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinestazolam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineestazolam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamestazolam and flurazepam both increase sedation. Use Caution/Monitor.formoterolestazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentingabapentin, estazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, estazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneestazolam and ganaxolone both increase sedation. Use Caution/Monitor.haloperidolestazolam and haloperidol both increase sedation. Use Caution/Monitor.hydromorphoneestazolam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and estazolam both increase sedation. Use Caution/Monitor.iloperidoneestazolam and iloperidone both increase sedation. Use Caution/Monitor.imipramineestazolam and imipramine both increase sedation. Use Caution/Monitor.isoproterenolestazolam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineketamine and estazolam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicestazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, estazolam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.levalbuterolestazolam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanolestazolam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineestazolam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineestazolam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineestazolam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamestazolam and loprazolam both increase sedation. Use Caution/Monitor.lorazepamestazolam and lorazepam both increase sedation. Use Caution/Monitor.lormetazepamestazolam and lormetazepam both increase sedation. Use Caution/Monitor.loxapineestazolam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledestazolam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, estazolam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for