of the other by sedation. Modify Therapy/Monitor Closely.ziprasidoneesketamine intranasal, ziprasidone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.zolpidemesketamine intranasal, zolpidem. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.zonisamideesketamine intranasal, zonisamide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.Minor (0)acetaminophen/pamabrom/pyrilamineMonitor Closely (1)esketamine intranasal, acetaminophen/pamabrom/pyrilamine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.acetazolamideMonitor Closely (1)esketamine intranasal, acetazolamide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.acrivastineMonitor Closely (2)esketamine intranasal, acrivastine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. acrivastine and esketamine intranasal both increase sedation. Use Caution/Monitor.alfentanilMonitor Closely (1)esketamine intranasal, alfentanil. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.alprazolamMonitor Closely (1)esketamine intranasal, alprazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.amisulprideMonitor Closely (1)amisulpride and esketamine intranasal both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)esketamine intranasal, amitriptyline. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.amobarbitalMonitor Closely (1)esketamine intranasal, amobarbital. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.amoxapineMonitor Closely (1)esketamine intranasal, amoxapine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.amphetamineMonitor Closely (1)esketamine intranasal, amphetamine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .amphetamine polistirexMonitor Closely (1)esketamine intranasal, amphetamine polistirex. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .arbaclofenMonitor Closely (1)esketamine intranasal, arbaclofen. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.aripiprazoleMonitor Closely (1)esketamine intranasal, aripiprazole. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.armodafinilMonitor Closely (1)esketamine intranasal, armodafinil. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .asenapineMonitor Closely (1)esketamine intranasal, asenapine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.asenapine transdermalMonitor Closely (1)asenapine transdermal and esketamine intranasal both increase sedation. Use Caution/Monitor.atomoxetineMonitor Closely (1)esketamine intranasal, atomoxetine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .avapritinibMonitor Closely (1)avapritinib and esketamine intranasal both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)esketamine intranasal, baclofen. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.belladonna and opiumMonitor Closely (1)esketamine intranasal, belladonna and opium. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.benperidolMonitor Closely (1)esketamine intranasal, benperidol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.benzhydrocodone/acetaminophenMonitor Closely (1)esketamine intranasal, benzhydrocodone/acetaminophen. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.brexanoloneMonitor Closely (1)brexanolone, esketamine intranasal. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)esketamine intranasal, brexpiprazole. Either increases levels of the other by sedation. Modify Therapy/Monitor Closely.brimonidineMonitor Closely (1)esketamine intranasal, brimonidine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.brivaracetamMonitor Closely (1)esketamine intranasal, brivaracetam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.brompheniramineMonitor Closely (1)esketamine intranasal, brompheniramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.buprenorphineMonitor Closely (1)esketamine intranasal, buprenorphine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.buprenorphine transdermalMonitor Closely (1)esketamine intranasal, buprenorphine transdermal. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.buprenorphine, long-acting injectionSerious - Use Alternative (1)buprenorphine, long-acting injection and esketamine intranasal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuspironeMonitor Closely (1)esketamine intranasal, buspirone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.butabarbitalMonitor Closely (1)esketamine intranasal, butabarbital. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.butalbitalMonitor Closely (1)esketamine intranasal, butalbital. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.butorphanolMonitor Closely (1)esketamine intranasal, butorphanol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.caffeineMonitor Closely (1)esketamine intranasal, caffeine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .calcium/magnesium/potassium/sodium oxybatesMonitor Closely (1)esketamine intranasal, calcium/magnesium/potassium/sodium oxybates. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.cannabidiolMonitor Closely (1)esketamine intranasal, cannabidiol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.carbamazepineMonitor Closely (1)esketamine intranasal, carbamazepine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.carbinoxamineMonitor Closely (1)esketamine intranasal, carbinoxamine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.cariprazineMonitor Closely (1)esketamine intranasal, cariprazine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.carisoprodolMonitor Closely (1)esketamine intranasal, carisoprodol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.cenobamateMonitor Closely (1)cenobamate, esketamine intranasal. Either increases effects of the other by sedation. Use Caution/Monitor.cetirizineMonitor Closely (1)esketamine intranasal, cetirizine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.chlordiazepoxideMonitor Closely (1)esketamine intranasal, chlordiazepoxide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.chlorpheniramineMonitor Closely (1)esketamine intranasal, chlorpheniramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.chlorpromazineMonitor Closely (1)esketamine intranasal, chlorpromazine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.chlorzoxazoneMonitor Closely (1)esketamine intranasal, chlorzoxazone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.clemastineMonitor Closely (1)esketamine intranasal, clemastine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.clomipramineMonitor Closely (1)esketamine intranasal, clomipramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.clonazepamMonitor Closely (1)esketamine intranasal, clonazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.clonidineMonitor Closely (2)esketamine intranasal, clonidine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. . esketamine intranasal, clonidine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.clorazepateMonitor Closely (1)esketamine intranasal, clorazepate. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.clozapineMonitor Closely (1)esketamine intranasal, clozapine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.codeineMonitor Closely (1)esketamine intranasal, codeine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.cyclobenzaprineMonitor Closely (1)esketamine intranasal, cyclobenzaprine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.cyproheptadineMonitor Closely (1)esketamine intranasal, cyproheptadine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.dantroleneMonitor Closely (1)esketamine intranasal, dantrolene. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.daridorexantMonitor Closely (1)esketamine intranasal and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluraneMonitor Closely (1)esketamine intranasal, desflurane. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.desipramineMonitor Closely (1)esketamine intranasal, desipramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.desloratadineMonitor Closely (1)esketamine intranasal, desloratadine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.deutetrabenazineMonitor Closely (1)esketamine intranasal, deutetrabenazine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.dexbrompheniramineMonitor Closely (1)esketamine intranasal, dexbrompheniramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.dexchlorpheniramineMonitor Closely (1)esketamine intranasal, dexchlorpheniramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.dexmethylphenidateMonitor Closely (1)esketamine intranasal, dexmethylphenidate. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .dextroamphetamineMonitor Closely (1)esketamine intranasal, dextroamphetamine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .diazepamMonitor Closely (1)esketamine intranasal, diazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.diazepam intranasalMonitor Closely (1)diazepam intranasal, esketamine intranasal. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionMonitor Closely (1)esketamine intranasal, diethylpropion. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .difelikefalinMonitor Closely (1)difelikefalin and esketamine intranasal both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)esketamine intranasal, dimenhydrinate. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.diphenhydramineMonitor Closely (1)esketamine intranasal, diphenhydramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.diphenoxylate hclMonitor Closely (1)esketamine intranasal, diphenoxylate hcl. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.dosulepinMonitor Closely (1)esketamine intranasal, dosulepin. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.doxepinMonitor Closely (1)esketamine intranasal, doxepin. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.doxylamineMonitor Closely (1)esketamine intranasal, doxylamine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.droperidolMonitor Closely (1)esketamine intranasal, droperidol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.efavirenzMonitor Closely (1)esketamine intranasal, efavirenz. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.emedastineMonitor Closely (1)esketamine intranasal, emedastine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamMonitor Closely (1)esketamine intranasal, estazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.eszopicloneMonitor Closely (1)esketamine intranasal, eszopiclone. Either increases toxicity of the other by sedation. Use Caution/Monitor.ethanolMonitor Closely (1)esketamine intranasal, ethanol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.ethosuximideMonitor Closely (1)esketamine intranasal, ethosuximide. Either increases toxicity of the other by sedation. Use Caution/Monitor.ethotoinMonitor Closely (1)esketamine intranasal, ethotoin. Either increases toxicity of the other by sedation. Use Caution/Monitor.ezogabineMonitor Closely (1)esketamine intranasal, ezogabine. Either increases levels of the other by sedation. Use Caution/Monitor.felbamateMonitor Closely (1)esketamine intranasal, felbamate. Either increases toxicity of the other by sedation. Use Caution/Monitor.fenfluramineMonitor Closely (1)fenfluramine, esketamine intranasal. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome.fentanylMonitor Closely (1)esketamine intranasal, fentanyl. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.fentanyl intranasalMonitor Closely (1)esketamine intranasal, fentanyl intranasal. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.fentanyl transdermalMonitor Closely (1)esketamine intranasal, fentanyl transdermal. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.fentanyl transmucosalMonitor Closely (1)esketamine intranasal, fentanyl transmucosal. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.fexofenadineMonitor Closely (1)esketamine intranasal, fexofenadine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.flibanserinMonitor Closely (1)esketamine intranasal, flibanserin. Either increases toxicity of the other by sedation. Use Caution/Monitor.fluphenazineMonitor Closely (1)esketamine intranasal, fluphenazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)esketamine intranasal, flurazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.fosphenytoinMonitor Closely (1)esketamine intranasal, fosphenytoin. Either increases toxicity of the other by sedation. Use Caution/Monitor.gabapentinMonitor Closely (2)esketamine intranasal, gabapentin. Either increases toxicity of the other by sedation. Use Caution/Monitor. gabapentin, esketamine intranasal. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (2)esketamine intranasal, gabapentin enacarbil. Either increases toxicity of the other by sedation. Use Caution/Monitor. gabapentin enacarbil, esketamine intranasal. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)esketamine intranasal and ganaxolone both increase sedation. Use Caution/Monitor.guanfacineMonitor Closely (2)esketamine intranasal, guanfacine. Either increases toxicity of the other by sedation. Use Caution/Monitor. esketamine intranasal, guanfacine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .haloperidolMonitor Closely (1)esketamine intranasal, haloperidol. Either increases toxicity of the other by sedation. Use Caution/Monitor.hydrocodoneMonitor Closely (1)esketamine intranasal, hydrocodone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.hydromorphoneMonitor Closely (1)esketamine intranasal, hydromorphone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.hydroxyzineMonitor Closely (1)esketamine intranasal, hydroxyzine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.iloperidoneMonitor Closely (1)esketamine intranasal, iloperidone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.imipramineMonitor Closely (1)esketamine intranasal, imipramine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.isocarboxazidMonitor Closely (1)esketamine intranasal, isocarboxazid. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with MAO-Is. .isofluraneMonitor Closely (1)esketamine intranasal, isoflurane. Either increases toxicity of the