sedation. Use Caution/Monitor.olanzapine and amitriptyline both increase QTc interval. Use Caution/Monitor.oliceridineamitriptyline, oliceridine. Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely.amitriptyline increases toxicity of oliceridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.oliceridine, chlordiazepoxide. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olodaterol inhaledamitriptyline and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. TCAs prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmiasopium tincturechlordiazepoxide and opium tincture both increase sedation. Use Caution/Monitor.onabotulinumtoxinAonabotulinumtoxinA and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.opium tinctureopium tincture and amitriptyline both increase sedation. Use Caution/Monitor.orphenadrineamitriptyline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.chlordiazepoxide and orphenadrine both increase sedation. Use Caution/Monitor.orphenadrine and amitriptyline both increase sedation. Use Caution/Monitor.osilodrostatosilodrostat and amitriptyline both increase QTc interval. Use Caution/Monitor.oxazepamchlordiazepoxide and oxazepam both increase sedation. Use Caution/Monitor.osimertinibosimertinib and amitriptyline both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.oxaliplatinoxaliplatin will increase the level or effect of amitriptyline by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.oxazepamoxazepam and amitriptyline both increase sedation. Use Caution/Monitor.oxybutyninoxybutynin and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin topicaloxybutynin topical and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin transdermaloxybutynin transdermal and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.oxycodoneoxycodone and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and oxycodone both increase sedation. Use Caution/Monitor.oxymetazoline intranasalamitriptyline increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Use Caution/Monitor. TCAs inhibit norepinephrine uptake in adrenergic neurons, thereby increasing synaptic norepinephrine levels. Coadministration with alpha1 agonists may cause increased adrenergic receptor stimulation. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs.oxymorphonechlordiazepoxide and oxymorphone both increase sedation. Use Caution/Monitor.oxymorphoneoxymorphone and amitriptyline both increase sedation. Use Caution/Monitor.ozanimodozanimod and amitriptyline both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidoneamitriptyline and paliperidone both increase QTc interval. Modify Therapy/Monitor Closely.chlordiazepoxide and paliperidone both increase sedation. Use Caution/Monitor.paliperidone and amitriptyline both increase sedation. Use Caution/Monitor.pancuroniumpancuronium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.papaveretumchlordiazepoxide and papaveretum both increase sedation. Use Caution/Monitor.papaveretumpapaveretum and amitriptyline both increase sedation. Use Caution/Monitor.papaverineamitriptyline and papaverine both increase sedation. Use Caution/Monitor.chlordiazepoxide and papaverine both increase sedation. Use Caution/Monitor.paroxetineamitriptyline and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely.pentazocinechlordiazepoxide and pentazocine both increase sedation. Use Caution/Monitor.pasireotideamitriptyline and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.pazopanibamitriptyline and pazopanib both increase QTc interval. Use Caution/Monitor.peginterferon alfa 2bpeginterferon alfa 2b, amitriptyline. Other (see comment). Use Caution/Monitor. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate.pentazocinepentazocine and amitriptyline both increase sedation. Use Caution/Monitor.amitriptyline and pentazocine both increase serotonin levels. Modify Therapy/Monitor Closely.pentobarbitalpentobarbital will decrease the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.pentobarbital will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.pentobarbital and amitriptyline both increase sedation. Use Caution/Monitor.pentobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.perampanelperampanel and chlordiazepoxide both increase sedation. Use Caution/Monitor.perphenazineperphenazine and amitriptyline both increase sedation. Use Caution/Monitor.perphenazinechlordiazepoxide and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazinechlordiazepoxide increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phenobarbital will decrease the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.phenobarbital will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.phenobarbital will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.phenobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.phenobarbital and amitriptyline both increase sedation. Use Caution/Monitor.phentermineamitriptyline increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineamitriptyline increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POchlordiazepoxide increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenylephrine POamitriptyline increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenylephrine ophthalmicamitriptyline, phenylephrine ophthalmic. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenytoinphenytoin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.phenytoin will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor therapeutic efficacy of amitriptyline; an increased dose may be required. Serum phenytoin levels should be obtained when tricyclic antidepressant agents are added to therapy due to the potential for impaired phenytoin metabolism and decreased seizure threshold. Tricyclic antidepressants when given concomitantly with anticonvulsants can increase CNS depression.phenytoin will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor therapeutic efficacy of amitriptyline; an increased dose may be required. Serum phenytoin levels should be obtained when tricyclic antidepressant agents are added to therapy due to the potential for impaired phenytoin metabolism and decreased seizure threshold. Tricyclic antidepressants when given concomitantly with anticonvulsants can increase CNS depression.pholcodineamitriptyline and pholcodine both increase sedation. Use Caution/Monitor.chlordiazepoxide and pholcodine both increase sedation. Use Caution/Monitor.physostigminephysostigmine increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.pimozidechlordiazepoxide and pimozide both increase sedation. Use Caution/Monitor.pilocarpinepilocarpine increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.pimozidepimozide and amitriptyline both increase sedation. Use Caution/Monitor.pirbuterolamitriptyline increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ponatinibponatinib increases levels of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.posaconazoleposaconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.posaconazoleamitriptyline and posaconazole both increase QTc interval. Modify Therapy/Monitor Closely.pralidoximepralidoxime and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.pregabalinpregabalin, amitriptyline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.pregabalin, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.primidone will decrease the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.primidone and amitriptyline both increase sedation. Use Caution/Monitor.primidone will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.primidone and chlordiazepoxide both increase sedation. Use Caution/Monitor.prochlorperazinechlordiazepoxide and prochlorperazine both increase sedation. Use Caution/Monitor.prochlorperazine and amitriptyline both increase QTc interval. Use Caution/Monitor.prochlorperazine and amitriptyline both increase sedation. Use Caution/Monitor.promethazinepromethazine and amitriptyline both increase sedation. Use Caution/Monitor.promethazine and chlordiazepoxide both increase sedation. Use Caution/Monitor.promethazine and amitriptyline both increase QTc interval. Use Caution/Monitor.propanthelinepropantheline and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.propofolpropofol and chlordiazepoxide both increase sedation. Use Caution/Monitor.propofolpropofol and amitriptyline both increase sedation. Use Caution/Monitor.propylhexedrineamitriptyline increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineamitriptyline and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.chlordiazepoxide and protriptyline both increase sedation. Use Caution/Monitor.amitriptyline and protriptyline both increase sedation. Use Caution/Monitor.pyridostigminepyridostigmine increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.quazepamchlordiazepoxide and quazepam both increase sedation. Use Caution/Monitor.quazepamquazepam and amitriptyline both increase sedation. Use Caution/Monitor.quercetinquercetin will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.quetiapinequetiapine, amitriptyline. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT.chlordiazepoxide and quetiapine both increase sedation. Use Caution/Monitor.quetiapine and amitriptyline both increase sedation. Use Caution/Monitor.quinineamitriptyline and quinine both increase QTc interval. Use Caution/Monitor.ramelteonchlordiazepoxide and ramelteon both increase sedation. Use Caution/Monitor.ramelteonamitriptyline and ramelteon both increase sedation. Use Caution/Monitor.ranolazineamitriptyline and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.rapacuroniumrapacuronium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.remifentanilamitriptyline, remifentanil. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. May also increase risk of serotonin syndrome.remimazolamremimazolam, chlordiazepoxide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.remimazolam, amitriptyline. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibribociclib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinrifabutin will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutin decreases levels of amitriptyline by increasing metabolism. Use Caution/Monitor.rifabutinrifabutin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifampinrifampin will decrease the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.rifampin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifampin will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifampin will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.rifapentinerifapentine will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.risperidonechlordiazepoxide and risperidone both increase sedation. Use Caution/Monitor.rilpivirinerilpivirine increases toxicity of amitriptyline by QTc interval. Use Caution/Monitor. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes.risperidoneamitriptyline and risperidone both increase QTc interval. Modify Therapy/Monitor Closely.risperidone and amitriptyline both increase sedation. Use Caution/Monitor.ritonavirritonavir will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.ritonavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Potential for increased toxicity. Consider lowering benzodiazepine dose.ritonavir will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rivastigminerivastigmine increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.rolapitantrolapitant will increase the level or effect of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.rizatriptanrizatriptan and amitriptyline both increase serotonin levels. Modify Therapy/Monitor Closely.rocuroniumrocuronium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.rolapitantrolapitant will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.romidepsinamitriptyline and romidepsin both increase QTc interval. Modify Therapy/Monitor Closely.rucaparibrucaparib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4