Caution/Monitor.clonidineasenapine and clonidine both increase sedation. Use Caution/Monitor.clorazepateasenapine and clorazepate both increase sedation. Use Caution/Monitor.clozapineasenapine and clozapine both increase sedation. Use Caution/Monitor.crizotinibcrizotinib and asenapine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.cyclobenzaprineasenapine and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineasenapine and cyproheptadine both increase sedation. Use Caution/Monitor.dantroleneasenapine and dantrolene both increase sedation. Use Caution/Monitor.daridorexantasenapine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. deferasiroxdeferasirox increases levels of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.desfluraneasenapine and desflurane both increase sedation. Use Caution/Monitor.desipramineasenapine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapine and desipramine both increase QTc interval. Use Caution/Monitor.asenapine and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineasenapine and deutetrabenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely. The risk for parkinsonism, neuroleptic malignant syndrome, and akathisia may be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics.asenapine and deutetrabenazine both increase sedation. Use Caution/Monitor.asenapine and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexbrompheniramineasenapine and dexbrompheniramine both increase sedation. Use Caution/Monitor.dexchlorpheniramineasenapine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.dextromethorphandextromethorphan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).diazepamasenapine and diazepam both increase sedation. Use Caution/Monitor.diclofenacdiclofenac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.difelikefalindifelikefalin and asenapine both increase sedation. Use Caution/Monitor.difenoxin hclasenapine and difenoxin hcl both increase sedation. Use Caution/Monitor.diflunisaldiflunisal decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.dihydroergotaminedihydroergotamine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).diltiazemasenapine and diltiazem both increase anti-hypertensive channel blocking. Use Caution/Monitor.dimenhydrinateasenapine and dimenhydrinate both increase sedation. Use Caution/Monitor.diphenhydramineasenapine and diphenhydramine both increase sedation. Use Caution/Monitor.diphenoxylate hclasenapine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.doxazosinasenapine and doxazosin both increase anti-hypertensive channel blocking. Use Caution/Monitor.doxepinasenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.doxepin and asenapine both increase QTc interval. Use Caution/Monitor.asenapine and doxepin both increase sedation. Use Caution/Monitor.doxylamineasenapine and doxylamine both increase sedation. Use Caution/Monitor.droperidolasenapine and droperidol both increase sedation. Use Caution/Monitor.duloxetineasenapine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.efavirenzasenapine and efavirenz both increase sedation. Use Caution/Monitor.eletriptaneletriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).enalaprilenalapril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.entacaponeasenapine and entacapone both increase sedation. Use Caution/Monitor.ergoloid mesylatesergoloid mesylates, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).ergotamineergotamine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).esketamine intranasalesketamine intranasal, asenapine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.esmololasenapine and esmolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.estazolamasenapine and estazolam both increase sedation. Use Caution/Monitor.eszopicloneasenapine and eszopiclone both increase sedation. Use Caution/Monitor.ethanolasenapine and ethanol both increase sedation. Use Caution/Monitor.ethosuximideasenapine and ethosuximide both increase sedation. Use Caution/Monitor.ethotoinasenapine and ethotoin both increase sedation. Use Caution/Monitor.etodolacetodolac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.exenatide injectable solutionasenapine, exenatide injectable solution. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.exenatide injectable suspensionasenapine, exenatide injectable suspension. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.ezogabineezogabine, asenapine. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.felbamateasenapine and felbamate both increase sedation. Use Caution/Monitor.felodipineasenapine and felodipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.fenfluramineasenapine decreases effects of fenfluramine by pharmacodynamic antagonism. Use Caution/Monitor. Potent serotonin receptor antagonists may decrease fenfluramine efficacy. If coadministered, monitor appropriately.asenapine and fenfluramine both increase sedation. Use Caution/Monitor.fenoprofenfenoprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.fentanylfentanyl, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).fexofenadineasenapine and fexofenadine both increase sedation. Use Caution/Monitor.flecainideasenapine will increase the level or effect of flecainide by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.flibanserinflibanserin, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).asenapine and flibanserin both increase sedation. Use Caution/Monitor.fluoxetineasenapine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapine and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazineasenapine and fluphenazine both increase QTc interval. Use Caution/Monitor.asenapine and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamasenapine and flurazepam both increase sedation. Use Caution/Monitor.flurbiprofenflurbiprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.fluvoxaminefluvoxamine will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Dose reduction may be necessaryfosinoprilfosinopril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.fostemsavirasenapine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.frovatriptanfrovatriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).gabapentinasenapine and gabapentin both increase sedation. Use Caution/Monitor.ganaxoloneasenapine and ganaxolone both increase sedation. Use Caution/Monitor.gemtuzumabasenapine and gemtuzumab both increase QTc interval. Use Caution/Monitor.glimepirideasenapine, glimepiride. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.glipizideasenapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.glyburideasenapine, glyburide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.guanfacineasenapine and guanfacine both increase sedation. Use Caution/Monitor.haloperidolasenapine will increase the level or effect of haloperidol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.haloperidol and asenapine both increase QTc interval. Use Caution/Monitor.asenapine and haloperidol both increase sedation. Use Caution/Monitor.hydrocodoneasenapine will increase the level or effect of hydrocodone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Hydromorphone (<3% of the circulating parent hydrocodone) is mainly formed by CYP2D6 mediated O-demethylation of hydrocodone. Hydromorphone may contribute to the total analgesic effect of hydrocodone.asenapine and hydrocodone both increase sedation. Use Caution/Monitor.hydromorphoneasenapine will increase the level or effect of hydromorphone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.hydroxyzineasenapine and hydroxyzine both increase sedation. Use Caution/Monitor.ibuprofenibuprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.ibuprofen IVibuprofen IV decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.ibutilideasenapine and ibutilide both increase QTc interval. Use Caution/Monitor.iloperidoneasenapine will increase the level or effect of iloperidone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.iloperidone increases effects of asenapine by pharmacodynamic synergism. Use Caution/Monitor.asenapine and iloperidone both increase sedation. Use Caution/Monitor.imidaprilimidapril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.imipramineasenapine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapine and imipramine both increase QTc interval. Use Caution/Monitor.asenapine and imipramine both increase sedation. Use Caution/Monitor.indacaterol, inhaledindacaterol, inhaled, asenapine. QTc interval. Use Caution/Monitor. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias.indapamideasenapine and indapamide both increase QTc interval. Use Caution/Monitor.indomethacinindomethacin decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.insulin aspartasenapine, insulin aspart. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.insulin degludecasenapine decreases effects of insulin degludec by Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required.insulin degludec/insulin aspartasenapine decreases effects of insulin degludec/insulin aspart by Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required.insulin detemirasenapine, insulin detemir. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.insulin glargineasenapine, insulin glargine. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.insulin glulisineasenapine, insulin glulisine. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.insulin inhaledasenapine decreases effects of insulin inhaled by Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required.insulin lisproasenapine, insulin lispro. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.insulin NPHasenapine, insulin NPH. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.isofluraneasenapine and isoflurane both increase sedation. Use Caution/Monitor.isradipineasenapine and isradipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.asenapine and isradipine both increase QTc interval. Use Caution/Monitor.ketamineasenapine and ketamine both increase sedation. Use Caution/Monitor.ketoprofenketoprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.ketorolacketorolac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.ketorolac intranasalketorolac intranasal decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.ketotifen, drug-eluting contact lensasenapine and ketotifen, drug-eluting contact lens both increase sedation. Use Caution/Monitor.labetalolasenapine and labetalol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.lamotrigineasenapine and lamotrigine both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, asenapine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol