AdultPediatricDosage Forms & Strengths albuterol (base)/ipratropium bromide aerosol metered-dose inhaler (Combivent Respimat) (100mcg/20mcg)/actuation nebulizer solution (generic) (2.5mg/0.5mg)/3mL Chronic Obstructive Pulmonary Disease Treatment of chronic obstructive pulmonary disease (COPD) in patients on regular bronchodilator who continue to have bronchospasm and require second bronchodilator Aerosol: 100 mcg/20 mcg (1 actuation of metered-dose inhaler) q6hr; not to exceed 6 actuations/day Nebulizer solution: 3 mL inhaled q6hr; not to exceed 3 mL q4hr Dosing Considerations Patients aged >65 years have higher steady-state systemic exposures for albuterol and ipratropiumSafety and efficacy not establishedInteraction CheckerEnter a drug name and albuterol/ipratropiumNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (4)cisapridealbuterol and cisapride both increase QTc interval. Contraindicated.dronedaronealbuterol and dronedarone both increase QTc interval. Contraindicated.saquinavirsaquinavir, albuterol. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated. Contraindicated. Saquinavir boosted with ritonavir increases risk of hypokalemia, QT prolongation, and cardiac arrhythmias.thioridazinealbuterol and thioridazine both increase QTc interval. Contraindicated.Serious - Use Alternative (27)amitriptylineamitriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amoxapineamoxapine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.azithromycinalbuterol and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.desipraminedesipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.doxepindoxepin, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fexinidazolefexinidazole and albuterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.glucagonglucagon increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .glucagon intranasalglucagon intranasal increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .hydroxychloroquine sulfatealbuterol and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.imipramineimipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.isocarboxazidisocarboxazid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.linezolidlinezolid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lofepraminelofepramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lopinaviralbuterol and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.macimorelinipratropium, macimorelin. unspecified interaction mechanism. Avoid or Use Alternate Drug. Drugs that may blunt the growth hormone (GH) response to macrimorelin may impact the accuracy of the diagnostic test. Allow sufficient washout time of drugs affecting GH release before administering macimorelin.maprotilinemaprotiline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.nortriptylinenortriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenelzinephenelzine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.pimozidealbuterol and pimozide both increase QTc interval. Contraindicated.pramlintidepramlintide, ipratropium. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.protriptylineprotriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.revefenacinrevefenacin and ipratropium both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.tranylcyprominetranylcypromine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.trazodonetrazodone, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trimipraminetrimipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.umeclidinium bromide/vilanterol inhaledipratropium, umeclidinium bromide/vilanterol inhaled. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Concomitant use with other anticholinergic-containing drugs may lead to additive anticholinergic adverse effects.Monitor Closely (402)abobotulinumtoxinAabobotulinumtoxinA increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .acebutololacebutolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acebutolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.aceclofenacaceclofenac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinacemetacin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidiniumipratropium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.alfentanilalfentanil increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamalprazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amantadineipratropium, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amilorideamiloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amiodaronealbuterol and amiodarone both increase QTc interval. Use Caution/Monitor.amisulpridealbuterol and amisulpride both increase QTc interval. Use Caution/Monitor.amisulpride and albuterol both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.amitriptylinealbuterol and amitriptyline both increase QTc interval. Use Caution/Monitor.ipratropium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.amitriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amobarbitalamobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineipratropium and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.amoxapineamoxapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.anagrelidealbuterol and anagrelide both increase QTc interval. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.apomorphinealbuterol and apomorphine both increase QTc interval. Use Caution/Monitor.arformoterolalbuterol and arformoterol both decrease serum potassium. Use Caution/Monitor.albuterol and arformoterol both decrease sedation. Use Caution/Monitor.albuterol and arformoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.aripiprazoleipratropium decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.aripiprazole increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ipratropium decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.aripiprazole increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.armodafinilalbuterol and armodafinil both decrease sedation. Use Caution/Monitor.atracuriumatracurium and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.arsenic trioxidealbuterol and arsenic trioxide both increase QTc interval. Use Caution/Monitor.artemether/lumefantrinealbuterol and artemether/lumefantrine both increase QTc interval. Use Caution/Monitor.asenapinealbuterol and asenapine both increase QTc interval. Use Caution/Monitor.asenapine transdermalasenapine transdermal and albuterol both increase QTc interval. Use Caution/Monitor.aspirinaspirin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalaspirin rectal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololatenolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.atomoxetineatomoxetine, albuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of tachycardia, increased blood pressure.atropineatropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.atropine IV/IMatropine IV/IM and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.azelastineazelastine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bedaquilinealbuterol and bedaquiline both increase QTc interval. Use Caution/Monitor.belladonna alkaloidsbelladonna alkaloids and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.belladonna and opiumipratropium and belladonna and opium both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opium increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazidealbuterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.benperidolipratropium decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.ipratropium decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.benperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benperidolbenperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetaminealbuterol and benzphetamine both decrease sedation. Use Caution/Monitor.albuterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.benztropinebenztropine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. betaxololbetaxolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.betaxolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.bethanecholbethanechol increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprololbisoprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.brompheniraminebrompheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanidealbuterol and bumetanide both decrease serum potassium. Use Caution/Monitor.buprenorphinebuprenorphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and buprenorphine both increase QTc interval. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.buprenorphine buccal and albuterol both increase QTc interval. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and albuterol both increase QTc interval. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and albuterol both increase QTc interval. Use Caution/Monitor.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and albuterol both increase QTc interval. Use Caution/Monitor.butabarbitalbutabarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalbutalbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolbutorphanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeinealbuterol and caffeine both decrease sedation. Use Caution/Monitor.carbacholcarbachol increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbenoxolonealbuterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxaminecarbinoxamine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolcarvedilol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.celecoxibcelecoxib increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprololceliprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.cevimelinecevimeline increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydratechloral hydrate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloroquinealbuterol and chloroquine both increase QTc interval. Use Caution/Monitor.chlorothiazidealbuterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.chlorpheniraminechlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazinechlorpromazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.ipratropium decreases levels of chlorpromazine by inhibition of GI absorption. Applies only