Therapy/Monitor Closely. Consider reducing the dose of P-glycoprotein (P-gp) substrates, if adverse reactions are experienced when administered concomitantly with stiripentol.succinylcholinesuccinylcholine increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (17)bendroflumethiazideformoterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.bumetanideformoterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chloroquinechloroquine increases toxicity of formoterol by QTc interval. Minor/Significance Unknown.chlorothiazideformoterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chlorthalidoneformoterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.cyclopenthiazideformoterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.ethacrynic acidformoterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.eucalyptuseucalyptus increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.furosemideformoterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.green teagreen tea increases effects of formoterol by pharmacodynamic synergism. Minor/Significance Unknown. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.hydrochlorothiazideformoterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.indapamideformoterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.methyclothiazideformoterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.metolazoneformoterol, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.noni juicenoni juice increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.sagesage increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.torsemideformoterol, torsemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.acebutololMonitor Closely (2)acebutolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. acebutolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aceclofenacMonitor Closely (1)aceclofenac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinMonitor Closely (1)acemetacin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.adagrasibSerious - Use Alternative (1)adagrasib, formoterol. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolMonitor Closely (3)albuterol and formoterol both decrease serum potassium. Use Caution/Monitor. albuterol and formoterol both decrease sedation. Use Caution/Monitor. albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfuzosinMonitor Closely (2)formoterol and alfuzosin both increase QTc interval. Use Caution/Monitor. alfuzosin and formoterol both increase QTc interval. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amilorideMonitor Closely (1)amiloride increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amiodaroneMonitor Closely (1)amiodarone and formoterol both increase QTc interval. Use Caution/Monitor.amisulprideSerious - Use Alternative (1)amisulpride and formoterol both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineMonitor Closely (1)amitriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)amitriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug. amitriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amobarbitalMonitor Closely (1)amobarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineMonitor Closely (1)amoxapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and formoterol both increase QTc interval. Avoid or Use Alternate Drug. amoxapine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.apomorphineMonitor Closely (1)apomorphine and formoterol both increase QTc interval. Use Caution/Monitor.arformoterolMonitor Closely (3)arformoterol and formoterol both decrease serum potassium. Use Caution/Monitor. arformoterol and formoterol both decrease sedation. Use Caution/Monitor. arformoterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (1)arformoterol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.aripiprazoleMonitor Closely (2)aripiprazole increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. aripiprazole and formoterol both increase QTc interval. Use Caution/Monitor.armodafinilMonitor Closely (1)formoterol and armodafinil both decrease sedation. Use Caution/Monitor.arsenic trioxideMonitor Closely (1)arsenic trioxide and formoterol both increase QTc interval. Use Caution/Monitor.artemetherMonitor Closely (1)artemether and formoterol both increase QTc interval. Use Caution/Monitor.artemether/lumefantrineSerious - Use Alternative (1)formoterol and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalMonitor Closely (1)asenapine transdermal and formoterol both increase QTc interval. Use Caution/Monitor.aspirinMonitor Closely (1)aspirin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalMonitor Closely (1)aspirin rectal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateMonitor Closely (1)aspirin/citric acid/sodium bicarbonate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololMonitor Closely (2)atenolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. atenolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atomoxetineMonitor Closely (2)atomoxetine and formoterol both increase QTc interval. Use Caution/Monitor. formoterol, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .azelastineMonitor Closely (1)azelastine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.azithromycinMonitor Closely (1)azithromycin and formoterol both increase QTc interval. Use Caution/Monitor.bedaquilineMonitor Closely (1)formoterol and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna and opiumMonitor Closely (1)belladonna and opium increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazideMonitor Closely (1)formoterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.benperidolMonitor Closely (1)benperidol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetamineMonitor Closely (2)formoterol and benzphetamine both decrease sedation. Use Caution/Monitor. formoterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.betaxololMonitor Closely (2)betaxolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. betaxolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprololMonitor Closely (2)bisoprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. bisoprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanideMonitor Closely (1)formoterol and bumetanide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.buprenorphine buccalMonitor Closely (1)buprenorphine buccal increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butabarbitalMonitor Closely (1)butabarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeineMonitor Closely (1)formoterol and caffeine both decrease sedation. Use Caution/Monitor.carbenoxoloneMonitor Closely (1)formoterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxamineMonitor Closely (1)carbinoxamine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolMonitor Closely (2)carvedilol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. carvedilol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celecoxibMonitor Closely (1)celecoxib increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprololMonitor Closely (2)celiprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. celiprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ceritinibMonitor Closely (1)ceritinib and formoterol both increase QTc interval. Use Caution/Monitor.chloral hydrateMonitor Closely (1)chloral hydrate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloroquineMinor (1)chloroquine increases toxicity of formoterol by QTc interval. Minor/Significance Unknown.chlorothiazideMonitor Closely (1)formoterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chlorpheniramineMonitor Closely (1)chlorpheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazineMonitor Closely (1)chlorpromazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.chlorthalidoneMonitor Closely (1)formoterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.choline magnesium trisalicylateMonitor Closely (1)choline magnesium trisalicylate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .cinnarizineMonitor Closely (1)cinnarizine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clarithromycinSerious - Use Alternative (1)clarithromycin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clemastineMonitor Closely (1)clemastine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineMonitor Closely (1)clomipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug. clomipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.clonazepamMonitor Closely (1)clonazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clorazepateMonitor Closely (1)clorazepate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineMonitor Closely (1)clozapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cobicistatMonitor Closely (1)cobicistat increases levels of budesonide inhaled by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.codeineMonitor Closely (1)codeine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclizineMonitor Closely (1)cyclizine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclopenthiazideMonitor Closely (1)formoterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.cyproheptadineMonitor Closely (1)cyproheptadine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dasatinibMonitor Closely (1)dasatinib and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.deflazacortMonitor Closely (1)formoterol and deflazacort both decrease serum potassium. Use Caution/Monitor.degarelixMonitor Closely (1)degarelix and formoterol both increase QTc interval. Use Caution/Monitor.desipramineMonitor Closely (1)desipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug. desipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluramineMonitor Closely (2)formoterol and dexfenfluramine both decrease sedation. Use Caution/Monitor. formoterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidateMonitor Closely (2)formoterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor. formoterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetamineMonitor Closely (2)formoterol and dextroamphetamine both decrease sedation. Use Caution/Monitor. formoterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramideMonitor Closely (1)dextromoramide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dichlorphenamideMonitor Closely (2)dichlorphenamide and formoterol both decrease serum potassium. Use Caution/Monitor. dichlorphenamide, formoterol. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diclofenacMonitor Closely (1)diclofenac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.diethylpropionMonitor Closely (2)formoterol and diethylpropion both decrease sedation. Use Caution/Monitor. formoterol and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diflunisalMonitor Closely (1)diflunisal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.digoxinMonitor Closely (1)digoxin increases