with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.mefloquinemefloquine increases toxicity of maprotiline by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.meperidinemaprotiline and meperidine both increase serotonin levels. Avoid or Use Alternate Drug.metaproterenolmaprotiline, metaproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.methamphetaminemaprotiline, methamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.methylene bluemethylene blue and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first.methylenedioxymethamphetaminemaprotiline, methylenedioxymethamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.methylphenidatemaprotiline, methylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.metoclopramide intranasalmaprotiline, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midodrinemaprotiline, midodrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.milnacipranmilnacipran and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.mirtazapinemirtazapine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibmobocertinib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. ]If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinmaprotiline and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nefazodonenefazodone and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.nilotinibmaprotiline and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.norepinephrinemaprotiline, norepinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.nortriptylinemaprotiline and nortriptyline both increase QTc interval. Avoid or Use Alternate Drug.maprotiline and nortriptyline both increase serotonin levels. Avoid or Use Alternate Drug.octreotidemaprotiline and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)maprotiline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.olanzapineolanzapine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasalmaprotiline and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronmaprotiline and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.oxaliplatinoxaliplatin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.ozanimodozanimod increases toxicity of maprotiline by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.paroxetineparoxetine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.perphenazineperphenazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.phendimetrazinemaprotiline, phendimetrazine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenterminemaprotiline, phentermine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenylephrinemaprotiline, phenylephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenylephrine POmaprotiline, phenylephrine PO. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.pirbuterolmaprotiline, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.promazinepromazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.propylhexedrinemaprotiline, propylhexedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.protriptylinemaprotiline and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.maprotiline and protriptyline both increase serotonin levels. Avoid or Use Alternate Drug.pseudoephedrinemaprotiline, pseudoephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.rasagilinerasagiline and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.ribociclibribociclib increases toxicity of maprotiline by QTc interval. Avoid or Use Alternate Drug.ropeginterferon alfa 2bropeginterferon alfa 2b and maprotiline both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.salmeterolmaprotiline, salmeterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.selegilineselegiline and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.selegiline transdermalselegiline transdermal and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.serdexmethylphenidate/dexmethylphenidatemaprotiline, serdexmethylphenidate/dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.sertralinesertraline and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.sevofluranesevoflurane and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.siponimodsiponimod and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.sodium oxybatemaprotiline, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.solifenacinsolifenacin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.St John's Wortmaprotiline and St John's Wort both increase serotonin levels. Avoid or Use Alternate Drug.terbutalinemaprotiline, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.tetrabenazinetetrabenazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.thioridazinethioridazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.trazodonemaprotiline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.trifluoperazinetrifluoperazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.trimipraminemaprotiline and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.maprotiline and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.umeclidinium bromide/vilanterol inhaledmaprotiline increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vandetanibmaprotiline, vandetanib. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.vemurafenibvemurafenib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended.venlafaxinevenlafaxine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaledmaprotiline increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vorinostatvorinostat and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.xylometazolinemaprotiline, xylometazoline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.yohimbeyohimbe, maprotiline. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.yohimbinemaprotiline, yohimbine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ziprasidonemaprotiline and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (331)5-HTPmaprotiline and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.abirateroneabiraterone increases levels of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.abobotulinumtoxinAabobotulinumtoxinA increases effects of maprotiline by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .aclidiniumaclidinium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.acrivastineacrivastine and maprotiline both increase sedation. Use Caution/Monitor.albuterolmaprotiline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and maprotiline both increase QTc interval. Use Caution/Monitor.alfentanilalfentanil and maprotiline both increase sedation. Use Caution/Monitor.alfuzosinmaprotiline and alfuzosin both increase QTc interval. Use Caution/Monitor.alfuzosin and maprotiline both increase QTc interval. Use Caution/Monitor.almotriptanalmotriptan and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.alprazolamalprazolam and maprotiline both increase sedation. Use Caution/Monitor.amitriptylineamitriptyline and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.amitriptyline and maprotiline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and maprotiline both increase sedation. Use Caution/Monitor.amoxapineamoxapine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and maprotiline both increase sedation. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.apomorphinemaprotiline and apomorphine both increase sedation. Use Caution/Monitor.arformoterolmaprotiline increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and maprotiline both increase QTc interval. Use Caution/Monitor.aripiprazolearipiprazole and maprotiline both increase sedation. Use Caution/Monitor.armodafinilmaprotiline increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.artemetherartemether and maprotiline both increase QTc interval. Use Caution/Monitor.asenapineasenapine and maprotiline both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and maprotiline both increase sedation. Use Caution/Monitor.atazanaviratazanavir increases levels of maprotiline by unspecified interaction mechanism. Use Caution/Monitor.atomoxetineatomoxetine and maprotiline both increase QTc interval. Use Caution/Monitor.atracuriumatracurium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineatropine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMatropine IV/IM and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.avapritinibavapritinib and maprotiline both increase sedation. Use Caution/Monitor.azelastineazelastine and maprotiline both increase sedation. Use Caution/Monitor.azithromycinmaprotiline and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenbaclofen and maprotiline both increase sedation. Use Caution/Monitor.bedaquilinemaprotiline and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsbelladonna alkaloids and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumbelladonna and opium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opium and maprotiline both increase sedation. Use Caution/Monitor.benperidolbenperidol and maprotiline both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, maprotiline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.benzphetaminemaprotiline increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benztropinebenztropine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. bethanecholbethanechol increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanolonebrexanolone,