Closely (1)amiloride and sulfasalazine both increase serum potassium. Modify Therapy/Monitor Closely.aminohippurate sodiumMinor (1)sulfasalazine will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.amoxicillinMonitor Closely (2)amoxicillin, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. amoxicillin, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.ampicillinMonitor Closely (2)ampicillin, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. ampicillin, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.anamuMinor (1)sulfasalazine and anamu both increase anticoagulation. Minor/Significance Unknown.antithrombin alfaMonitor Closely (1)antithrombin alfa and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.antithrombin IIIMonitor Closely (1)antithrombin III and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.apalutamideMonitor Closely (1)apalutamide will decrease the level or effect of sulfasalazine by increasing elimination. Use Caution/Monitor. Apalutamide weakly induces BCRP and may decrease systemic exposure of drugs that are BCRP substrates.arformoterolMonitor Closely (1)sulfasalazine increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.argatrobanMonitor Closely (1)argatroban and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.asenapineMonitor Closely (1)sulfasalazine decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.aspirinMonitor Closely (2)aspirin and sulfasalazine both increase anticoagulation. Use Caution/Monitor. aspirin and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.aspirin rectalMonitor Closely (2)aspirin rectal and sulfasalazine both increase anticoagulation. Use Caution/Monitor. aspirin rectal and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin rectal will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.aspirin/citric acid/sodium bicarbonateMonitor Closely (2)aspirin/citric acid/sodium bicarbonate and sulfasalazine both increase anticoagulation. Use Caution/Monitor. aspirin/citric acid/sodium bicarbonate and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin/citric acid/sodium bicarbonate will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.atenololMonitor Closely (2)sulfasalazine decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. atenolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.axicabtagene ciloleucelSerious - Use Alternative (2)sulfasalazine, axicabtagene ciloleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. axicabtagene ciloleucel, sulfasalazine. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.azilsartanMonitor Closely (2)sulfasalazine, azilsartan. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. sulfasalazine decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.balsalazideMinor (1)sulfasalazine will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.bemiparinMonitor Closely (1)bemiparin and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.benazeprilMonitor Closely (2)benazepril, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. sulfasalazine decreases effects of benazepril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Potential for dangerous interaction. Use with caution and monitor closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.bendroflumethiazideMonitor Closely (1)sulfasalazine increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)bendroflumethiazide will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.betaxololMonitor Closely (2)sulfasalazine decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. betaxolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.bisoprololMonitor Closely (2)sulfasalazine decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. bisoprolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.bivalirudinMonitor Closely (1)bivalirudin and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.brexucabtagene autoleucelSerious - Use Alternative (2)sulfasalazine, brexucabtagene autoleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. brexucabtagene autoleucel, sulfasalazine. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.brinzolamideMonitor Closely (1)brinzolamide, sulfasalazine. Either increases levels of the other by Other (see comment). Use Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates from plasma to the CNS, leading to potential neurotoxicity.budesonideMonitor Closely (1)sulfasalazine, budesonide. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.Minor (1)budesonide decreases levels of sulfasalazine by increasing renal clearance. Minor/Significance Unknown.bumetanideMonitor Closely (2)sulfasalazine decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. sulfasalazine increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)sulfasalazine, bumetanide. Other (see comment). Minor/Significance Unknown. Comment: Salicylates are less likely than other NSAIDs to interact w/bumetanide.bupivacaine implantMonitor Closely (1)sulfasalazine, bupivacaine implant. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.calcium carbonateMinor (1)calcium carbonate, sulfasalazine. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).candesartanMonitor Closely (3)candesartan, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. sulfasalazine decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. candesartan and sulfasalazine both increase serum potassium. Use Caution/Monitor.captoprilMonitor Closely (2)captopril, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. sulfasalazine decreases effects of captopril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.carbenoxoloneMonitor Closely (1)sulfasalazine increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolMonitor Closely (2)sulfasalazine decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. carvedilol and sulfasalazine both increase serum potassium. Use Caution/Monitor.cefaclorMinor (1)cefaclor will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefadroxilMinor (1)cefadroxil will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefamandoleMinor (1)cefamandole will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefazolinMinor (1)cefazolin will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefepimeMinor (1)cefepime will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefotaximeMinor (1)cefotaxime will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefpiromeMinor (1)cefpirome will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefprozilMinor (1)cefprozil will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.ceftazidimeMinor (1)ceftazidime will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.ceftibutenMinor (1)ceftibuten will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.celecoxibMonitor Closely (2)celecoxib and sulfasalazine both increase anticoagulation. Use Caution/Monitor. celecoxib and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)celecoxib will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.celiprololMonitor Closely (2)sulfasalazine decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis. celiprolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.cephalexinMinor (1)cephalexin will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.chlorothiazideMonitor Closely (1)sulfasalazine increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)chlorothiazide will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.chlorpropamideMonitor Closely (1)sulfasalazine increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.Minor (2)sulfasalazine will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. sulfasalazine increases effects of chlorpropamide by plasma protein binding competition. Minor/Significance Unknown. Large dose of salicylate.chlorthalidoneMonitor Closely (1)sulfasalazine increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)chlorthalidone will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.choline magnesium trisalicylateMonitor Closely (2)choline magnesium trisalicylate and sulfasalazine both increase anticoagulation. Use Caution/Monitor. choline magnesium trisalicylate and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)choline magnesium trisalicylate will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.ciltacabtagene autoleucelSerious - Use Alternative (2)sulfasalazine, ciltacabtagene autoleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. ciltacabtagene autoleucel, sulfasalazine. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.cinnamonMonitor Closely (1)sulfasalazine and cinnamon both increase anticoagulation. Use Caution/Monitor.clomipramineMonitor Closely (1)clomipramine, sulfasalazine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.clopidogrelMonitor Closely (1)clopidogrel, sulfasalazine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.cordycepsMonitor Closely (1)sulfasalazine and cordyceps both increase anticoagulation. Use Caution/Monitor.cortisoneMonitor Closely (1)sulfasalazine, cortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.Minor (1)cortisone decreases levels of sulfasalazine by increasing renal clearance. Minor/Significance Unknown.creatineMinor (1)creatine, sulfasalazine. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction) Combination may have additive nephrotoxic effects.cyanocobalaminMinor (1)sulfasalazine decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.cyclopenthiazideMonitor Closely (1)sulfasalazine increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)cyclopenthiazide will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cyclosporineMonitor Closely (1)cyclosporine will increase the level or effect of sulfasalazine by Other (see comment). Use Caution/Monitor. Cyclosporine, a BCRP inhibitor, may increase levels of sulfasalazine (a BCRP substrate) when combined.dalteparinMonitor Closely (1)dalteparin and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.danshenMinor (1)sulfasalazine and danshen both increase anticoagulation. Minor/Significance Unknown.darolutamideMonitor Closely (1)darolutamide will increase the level or effect of sulfasalazine by Other (see comment). Modify Therapy/Monitor Closely. Darolutamide is a BCRP inhibitor. Avoid coadministration with BCRP inhibitors. If use is unavoidable, closely monitor for adverse reactions and consider dose reduction of BCRP substrate drug (refer BCRP substrate prescribing information).deferiproneSerious - Use Alternative (1)deferiprone, sulfasalazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid use of deferiprone with other drugs known to be associated with neutropenia or agranulocytosis; if an alternative is not possible, monitor absolute neutrophil count more frequently.deflazacortMonitor Closely (1)sulfasalazine, deflazacort. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.Minor (1)deflazacort decreases levels of sulfasalazine by increasing renal clearance. Minor/Significance Unknown.devil's clawMinor (1)sulfasalazine and devil's claw both increase anticoagulation. Minor/Significance Unknown.dexamethasoneMonitor Closely (1)sulfasalazine, dexamethasone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.Minor (1)dexamethasone decreases levels of sulfasalazine by increasing renal clearance. Minor/Significance Unknown.diclofenacMonitor Closely (2)diclofenac and sulfasalazine both increase anticoagulation. Use Caution/Monitor. diclofenac and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)diclofenac will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.dicloxacillinMonitor Closely (2)dicloxacillin, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. dicloxacillin, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.diflunisalMonitor Closely (2)diflunisal and sulfasalazine both increase anticoagulation. Use Caution/Monitor. diflunisal and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)diflunisal will increase the