low-protein-binding filter (0.2-1.2 micron) RA or PJIA: Infuse IV over 30 min aGvHD: Infuse IV over 60 min Finish infusion within 24 hr of reconstitution Do not administer with any other drugs SC Administration Prefilled syringes and autoinjectors are intended for SC use only and are not for IV infusion Remove prefilled syringe or autoinjector from refrigerator and equilibrate to room temperature before administration Inspect visually for particulate matter and discoloration prior to administration; discard if particulate matter or discoloration observed; solution should appear clear and colorless to pale yellow Inject full amount SC (ie, 1 mL) Rotate injection site between abdomen (except for 2-inch area around navel), thigh, or outer area of upper arms (if administered by care giver) May use same thigh for weekly injections, as long as each injection is at leat 1-inch away from the last area injected Do not inject into areas where the skin is tender, bruised, red, or hard Storage Unused vials (lyophilized powder) Refrigerate at 2-8°C (36-46°F); protect from light by storing in original package until time of use Dilute solutions Store at room temperature or refrigerated for up to 24 hr Prefilled syringes or autoinjectors Refrigerate at 2-8°C (36-46°F); protect from light by storing in original package until time of use Do not allow prefilled syringe or autoinjector to freeze BRAND FORM. UNIT PRICE PILL IMAGE Orencia subcutaneous- 125 mg/mL solutionOrencia subcutaneous- 87.5 mg/0.7 mL solutionOrencia subcutaneous- 50 mg/0.4 mL solutionOrencia ClickJect subcutaneous- 125 mg/mL syringeCopyright © 2010 First DataBank, Inc.Print Patient Educationabatacept subcutaneous ABATACEPT - SUBCUTANEOUS INJECTION (a-BAT-a-sept) COMMON BRAND NAME(S): Orencia USES: This medication is used to treat rheumatoid arthritis, a condition in which the body's own defense system (immune system) attacks healthy tissue. This leads to swelling in the joints, which causes pain and makes it harder to move. Abatacept works by weakening your immune system. This effect helps to slow down joint damage and reduce joint pain and swelling so you can move better. This medication is also used to treat other types of arthritis (such as juvenile idiopathic arthritis, psoriatic arthritis). HOW TO USE: Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist before you start receiving abatacept and each time you get a treatment. If you have any questions, ask your doctor or pharmacist.This drug is given by injection under the skin of your thigh, abdomen, or upper arm as directed by your doctor, usually once a week. Your doctor may direct you to first receive abatacept by injection into a vein (loading dose) before starting treatment with this form of the medication. If you are switching from regularly scheduled injections into a vein, carefully follow your doctor's directions for when to start using this medication (usually instead of the next scheduled dose).The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight.Remove this medication from the refrigerator and leave it at room temperature for 30 to 60 minutes before injecting. Do not warm up this medication any other way. For example, do not heat it in the microwave or place it in hot water.If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Do not inject into any areas of skin that are sore, bruised, red, scaly, or hard.Learn how to store and discard medical supplies safely.Use this medication regularly to get the most benefit from it. To help you remember, mark your calendar to keep track of when you need to receive the next dose.Tell your doctor if your symptoms do not get better or if they get worse. SIDE EFFECTS: Headache, nausea, or cold symptoms such as stuffy head/nose may occur. Pain, irritation, or swelling at/near the injection site may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Because abatacept works by weakening the immune system, it may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn't go away, fever, chills, cough).Rarely, patients using abatacept have developed cancer (such as lymphoma, lung/skin cancer). Tell your doctor right away if you develop symptoms such as unusual lumps/growths/skin changes, swollen glands, night sweats, unexplained weight loss, shortness of breath, wheezing.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before using abatacept, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: cancer, chronic obstructive pulmonary disease-COPD, current/recent/returning infection (such as tuberculosis, hepatitis), immune system disorder (such as HIV infection, bone marrow disorder).Abatacept can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.Tell your health care professional that you are using abatacept before having any immunizations/vaccinations. Certain types of vaccines (live vaccines) should not be given during or within 3 months after the last dose of this medication. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).Children using this medication should have all recommended vaccinations before starting treatment with abatacept. Ask the child's doctor for details.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: anakinra, rituximab, TNF blocking agents (such as adalimumab, etanercept, infliximab). OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. NOTES: Do not share this medication with others.Lab and/or medical tests (such as tuberculosis skin test, test for hepatitis B virus, skin exams) should be done before you start taking this medication and while you are taking it. Keep all medical and lab appointments. Consult your doctor for more details. MISSED DOSE: It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up. STORAGE: Store in the refrigerator away from light. Do not freeze. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). Information last revised March 2023. Copyright(c) 2023 First Databank, Inc. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. FormularyPatient DiscountsAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.Create Your List of PlansAdding plans allows you to:View the formulary and any restrictions for each plan.Manage and view all your plans together – even plans in different states.Compare formulary status to other drugs in the same class.Access your plan list on any device – mobile or desktop. The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. View explanations for tiers and restrictions Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. 2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs. 3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs. 4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. NC NOT COVERED – Drugs that are not covered by the plan. Code Definition PA Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. 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