AdultPediatricGeriatricDosage Forms & Strengths capsule 25mg 50mg 100mg Depresssion Outpatient Initial: 50-75 mg PO qDay in divided doses; gradually titrate upward q2-3Weeks Maintentance: 50-150 mg PO qDay; may increase up to 200 mg/day if needed Adolscents: Not to exceed 100 mg/day Inpatient 100 mg PO qDay; initially, may increase over a few days up to 200 mg/day May increase up to 250-300 mg/day if no improvement in 2-3 weeks Dosage Forms & Strengths capsule 25mg 50mg 100mg Depression <12 years: Safety and efficacy not established ≥12 years: 50 mg/day initially; titrate to 100 mg/day Administer lowest effective dose for maintenanceAvoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension (Beers criteria) Consider alternatives; if must use, initiate with lower initial dose 50 mg/day PO initially; may increase up to 100 mg/dayInteraction CheckerEnter a drug name and trimipramineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (15)disopyramidetrimipramine and disopyramide both increase QTc interval. Contraindicated.ibutilidetrimipramine and ibutilide both increase QTc interval. Contraindicated.indapamidetrimipramine and indapamide both increase QTc interval. Contraindicated.iobenguane I 123trimipramine decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Contraindicated. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results.isocarboxazidisocarboxazid and trimipramine both increase serotonin levels. Contraindicated.pentamidinetrimipramine and pentamidine both increase QTc interval. Contraindicated.phenelzinephenelzine and trimipramine both increase serotonin levels. Contraindicated.pimozidetrimipramine and pimozide both increase QTc interval. Contraindicated.procainamidetrimipramine and procainamide both increase QTc interval. Contraindicated.procarbazineprocarbazine and trimipramine both increase serotonin levels. Contraindicated. Combination is contraindicated within 2 weeks of MAOI use.quinidinequinidine and trimipramine both increase QTc interval. Contraindicated.safinamidetrimipramine, safinamide. Either increases toxicity of the other by serotonin levels. Contraindicated. Concomitant use could result in life-threatening serotonin syndrome.selegilineselegiline and trimipramine both increase serotonin levels. Contraindicated. Concurrent use or use within 14 days of selegiline treatment is contraindicatedsotaloltrimipramine and sotalol both increase QTc interval. Contraindicated.tranylcyprominetranylcypromine and trimipramine both increase serotonin levels. Contraindicated.Serious - Use Alternative (148)abametapirabametapir will increase the level or effect of trimipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.adagrasibadagrasib, trimipramine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuteroltrimipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amiodaronetrimipramine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amitriptylineamitriptyline and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.amoxapineamoxapine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.apalutamideapalutamide will decrease the level or effect of trimipramine by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with drugs that are CYP2C19 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered.apalutamide will decrease the level or effect of trimipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.arformoteroltrimipramine, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.arsenic trioxidetrimipramine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinetrimipramine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.benzphetaminetrimipramine, benzphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.buprenorphinebuprenorphine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalbuprenorphine transdermal and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.buspironetrimipramine and buspirone both increase serotonin levels. Avoid or Use Alternate Drug.calcium/magnesium/potassium/sodium oxybatestrimipramine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.chlorpromazinechlorpromazine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug. Citalopram may increase TCA levels. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Potential risk for QT prolongation. ECG monitoring is recommended.citalopram and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.clarithromycintrimipramine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.clomipramine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.clonidinetrimipramine decreases effects of clonidine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.cyclobenzaprinetrimipramine and cyclobenzaprine both increase serotonin levels. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of trimipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. desipraminedesipramine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.desipramine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.desvenlafaxinetrimipramine and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.dexfenfluraminetrimipramine, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexmethylphenidatetrimipramine, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextroamphetaminetrimipramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextromethorphantrimipramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.diethylpropiontrimipramine, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dobutaminetrimipramine, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilidetrimipramine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetrondolasetron, trimipramine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.donepezildonepezil and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.dopaminetrimipramine, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexaminetrimipramine, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.doxepindoxepin and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.doxepin and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.dronedaronetrimipramine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidoltrimipramine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineduloxetine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.encorafenibencorafenib and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.ephedrinetrimipramine, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineepinephrine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.trimipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine racemicepinephrine racemic and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.trimipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.erythromycin basetrimipramine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatetrimipramine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatetrimipramine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatetrimipramine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramescitalopram and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.fenfluraminetrimipramine, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fexinidazolefexinidazole and trimipramine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of trimipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.fluconazoletrimipramine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.fluphenazinefluphenazine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.fluvoxaminefluvoxamine will increase the level or effect of trimipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.formoteroltrimipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.trimipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fosamprenavirfosamprenavir increases levels of trimipramine by decreasing metabolism. Avoid or Use Alternate Drug.fosphenytoinfosphenytoin will decrease the level or effect of trimipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of trimipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.granisetrongranisetron, trimipramine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.guanfacinetrimipramine decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.haloperidoltrimipramine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydroxychloroquine sulfatehydroxychloroquine sulfate and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.idelalisibidelalisib will increase the level or effect of trimipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substratesimipramineimipramine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.imipramine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.iobenguane I 131trimipramine will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.isoproterenoltrimipramine, isoproterenol. Other (see comment).