Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .atomoxetine and formoterol both increase QTc interval. Use Caution/Monitor.atropineatropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMatropine IV/IM and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.azelastineazelastine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.azithromycinazithromycin and formoterol both increase QTc interval. Use Caution/Monitor.bedaquilineformoterol and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsbelladonna alkaloids and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumbelladonna and opium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opium increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazideformoterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.benperidolaclidinium decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.benperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benperidolbenperidol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetamineformoterol and benzphetamine both decrease sedation. Use Caution/Monitor.formoterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.benztropinebenztropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.betaxololbetaxolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.betaxolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.bethanecholbethanechol increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprololbisoprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.brompheniraminebrompheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanideformoterol and bumetanide both decrease serum potassium. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butabarbitalbutabarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalbutalbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolbutorphanol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeineformoterol and caffeine both decrease sedation. Use Caution/Monitor.carbacholcarbachol increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbenoxoloneformoterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxaminecarbinoxamine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolcarvedilol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.celecoxibcelecoxib increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprololceliprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.ceritinibceritinib and formoterol both increase QTc interval. Use Caution/Monitor.cevimelinecevimeline increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydratechloral hydrate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorothiazideformoterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.chlorpheniraminechlorpheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazinechlorpromazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.chlorthalidoneformoterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.cisatracuriumcisatracurium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.choline magnesium trisalicylatecholine magnesium trisalicylate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .cinnarizinecinnarizine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clemastineclemastine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineclomipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.clonazepamclonazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineaclidinium decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.clozapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.clorazepateclorazepate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineclozapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.codeinecodeine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclizinecyclizine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclizine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclopenthiazideformoterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.cyproheptadinecyproheptadine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.darifenacindarifenacin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.dasatinibdasatinib and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.deflazacortformoterol and deflazacort both decrease serum potassium. Use Caution/Monitor.degarelixdegarelix and formoterol both increase QTc interval. Use Caution/Monitor.desipramineaclidinium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.desipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dicyclominedicyclomine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.dexfenfluramineformoterol and dexfenfluramine both decrease sedation. Use Caution/Monitor.formoterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidinedexmedetomidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidateformoterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor.formoterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetamineformoterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.formoterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramidedextromoramide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphinediamorphine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dichlorphenamidedichlorphenamide and formoterol both decrease serum potassium. Use Caution/Monitor.dichlorphenamide, formoterol. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diclofenacdiclofenac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.diethylpropionformoterol and diethylpropion both decrease sedation. Use Caution/Monitor.formoterol and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.difenoxin hcldifenoxin hcl increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diflunisaldiflunisal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.digoxindigoxin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.dimenhydrinatedimenhydrinate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenhydraminediphenhydramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenhydramine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenoxylate hcldiphenoxylate hcl increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezildonepezil increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.dipipanonedipipanone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dobutaminedobutamine and formoterol both decrease serum potassium. Use Caution/Monitor.dobutamine and formoterol both decrease sedation. Use Caution/Monitor.dobutamine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dolasetrondolasetron and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.donepezildonepezil and formoterol both increase QTc interval. Use Caution/Monitor.donepezil transdermaldonepezil transdermal, aclidinium. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.dopamineformoterol and dopamine both decrease sedation. Use Caution/Monitor.formoterol and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexaminedopexamine and formoterol both decrease serum potassium. Use Caution/Monitor.dopexamine and formoterol both decrease sedation. Use Caution/Monitor.dopexamine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexamine, formoterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.dosulepinaclidinium and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepinaclidinium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepin increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.droperidolaclidinium decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.droperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.droperidol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.drospirenonedrospirenone increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.echothiophate iodideechothiophate iodide increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.efavirenzefavirenz and formoterol both increase QTc interval. Use Caution/Monitor.encorafenibencorafenib and formoterol both increase QTc interval. Use Caution/Monitor.ephedrineephedrine and formoterol both decrease serum potassium. Use Caution/Monitor.ephedrine and formoterol both decrease sedation. Use Caution/Monitor.ephedrine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrineepinephrine and formoterol both decrease serum potassium. Use Caution/Monitor.epinephrine and formoterol both decrease sedation. Use Caution/Monitor.epinephrine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrine racemicformoterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.formoterol and epinephrine racemic both decrease sedation. Use Caution/Monitor.formoterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.eribulineribulin and formoterol both increase QTc interval. Use Caution/Monitor.escitalopramescitalopram increases toxicity of formoterol by QTc interval. Use Caution/Monitor.esmololesmolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.esmolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.estazolamestazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethacrynic acidformoterol and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.ethanolethanol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.etodolacetodolac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fenfluramineformoterol and fenfluramine both decrease sedation. Use Caution/Monitor.formoterol and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.fenoprofenfenoprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fesoterodinefesoterodine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.fingolimodfingolimod and formoterol both increase QTc interval. Use Caution/Monitor.flavoxateflavoxate and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.flecainideflecainide and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.fluoxetinefluoxetine and formoterol both increase QTc interval. Modify Therapy/Monitor Closely. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular systemfluphenazineaclidinium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.fluphenazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurazepamflurazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.galantaminegalantamine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurbiprofenflurbiprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluvoxaminefluvoxamine and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.foscarnetformoterol and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.fostemsavirformoterol and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. furosemideformoterol and furosemide both decrease serum potassium. Use Caution/Monitor.gemifloxacingemifloxacin and formoterol both increase QTc interval. Use Caution/Monitor.gentamicinformoterol and gentamicin both decrease serum potassium. Use Caution/Monitor.gilteritinibgilteritinib and formoterol both increase QTc interval. Use Caution/Monitor.glycopyrrolateglycopyrrolate and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrrolate inhaledglycopyrrolate inhaled and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrronium tosylate topicalglycopyrronium tosylate topical, aclidinium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.goserelingoserelin increases toxicity of formoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.haloperidolhaloperidol increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.haloperidol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.henbanehenbane and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.histrelinhistrelin increases toxicity of formoterol by