interaction is not clear, use caution. Use Caution/Monitor.epinephrinelorazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemiclorazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, lorazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and lorazepam both increase sedation. Use Caution/Monitor.ethanollorazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and lorazepam both increase sedation. Use Caution/Monitor.fenfluraminelorazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinlorazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazinelorazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and lorazepam both increase sedation. Use Caution/Monitor.formoterollorazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentingabapentin, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxolonelorazepam and ganaxolone both increase sedation. Use Caution/Monitor.haloperidollorazepam and haloperidol both increase sedation. Use Caution/Monitor.hyaluronidasehyaluronidase, lorazepam. Other (see comment). Use Caution/Monitor. Comment: Drug combination has been found to be incompatible.hydromorphonelorazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and lorazepam both increase sedation. Use Caution/Monitor.iloperidonelorazepam and iloperidone both increase sedation. Use Caution/Monitor.imipraminelorazepam and imipramine both increase sedation. Use Caution/Monitor.isoproterenollorazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineketamine and lorazepam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmiclorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, lorazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantlemborexant, lorazepam. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.levalbuterollorazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanollorazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetaminelorazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepraminelorazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidinelorazepam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamloprazolam and lorazepam both increase sedation. Use Caution/Monitor.lormetazepamlorazepam and lormetazepam both increase sedation. Use Caution/Monitor.loxapinelorazepam and loxapine both increase sedation. Use Caution/Monitor.lorazepam, loxapine. Mechanism: unknown. Use Caution/Monitor. Risk of resp. depression, hypotension.loxapine inhaledlorazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lorazepam, loxapine inhaled. Mechanism: unknown. Use Caution/Monitor. Risk of resp. depression, hypotension.lurasidonelurasidone, lorazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilinelorazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanalorazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninlorazepam and melatonin both increase sedation. Use Caution/Monitor.meperidinelorazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamatelorazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenollorazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonelorazepam and metaxalone both increase sedation. Use Caution/Monitor.methadonelorazepam and methadone both increase sedation. Use Caution/Monitor.methamphetaminelorazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamollorazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminelorazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidate transdermalmethylphenidate transdermal will increase the level or effect of lorazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. midazolamlorazepam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinelorazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapinelorazepam and mirtazapine both increase sedation. Use Caution/Monitor.modafinillorazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinelorazepam and morphine both increase sedation. Use Caution/Monitor.motherwortlorazepam and motherwort both increase sedation. Use Caution/Monitor.moxonidinelorazepam and moxonidine both increase sedation. Use Caution/Monitor.nabilonelorazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphinelorazepam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrinelorazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinelorazepam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapinelorazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tincturelorazepam and opium tincture both increase sedation. Use Caution/Monitor.orlistatorlistat decreases levels of lorazepam by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of convulsions.orphenadrinelorazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamlorazepam and oxazepam both increase sedation. Use Caution/Monitor.oxycodonelorazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonelorazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonelorazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumlorazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverinelorazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocinelorazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and lorazepam both increase sedation. Use Caution/Monitor.perampanelperampanel and lorazepam both increase sedation. Use Caution/Monitor.perphenazinelorazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazinelorazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and lorazepam both increase sedation. Use Caution/Monitor.phenterminelorazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinelorazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POlorazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinelorazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozidelorazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterollorazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinpregabalin, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and lorazepam both increase sedation. Use Caution/Monitor.prochlorperazinelorazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and lorazepam both increase sedation. Use Caution/Monitor.propofolpropofol and lorazepam both increase sedation. Use Caution/Monitor.propylhexedrinelorazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinelorazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamlorazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapinelorazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonlorazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, lorazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.risperidonelorazepam and risperidone both increase sedation. Use Caution/Monitor.salmeterollorazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcaplorazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and lorazepam both increase sedation. Use Caution/Monitor.sevelamersevelamer decreases levels of lorazepam by increasing elimination. Use Caution/Monitor.sevofluranesevoflurane and lorazepam both increase sedation. Use Caution/Monitor.shepherd's purselorazepam and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, lorazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanillorazepam and sufentanil both increase sedation. Use Caution/Monitor.suvorexantsuvorexant and lorazepam both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessarytapentadollorazepam and tapentadol both increase sedation. Use Caution/Monitor.teduglutideteduglutide increases levels of lorazepam by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.temazepamlorazepam and temazepam both increase sedation. Use Caution/Monitor.terbutalinelorazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazinelorazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixenelorazepam and thiothixene both increase sedation. Use Caution/Monitor.topiramatelorazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadollorazepam and tramadol both increase sedation. Use Caution/Monitor.trazodonelorazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamlorazepam and triazolam both increase sedation. Use Caution/Monitor.triclofoslorazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazinelorazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipraminelorazepam and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and lorazepam both increase sedation. Use Caution/Monitor.xylometazolinelorazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinelorazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidelorazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidonelorazepam and ziprasidone both increase sedation. Use Caution/Monitor.zotepinelorazepam and zotepine both increase sedation. Use Caution/Monitor.Minor (31)acetaminophenlorazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen IVlorazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen rectallorazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.atracuriumlorazepam decreases effects of atracurium by pharmacodynamic antagonism. Minor/Significance Unknown.biotinlorazepam decreases levels of biotin by unspecified interaction mechanism. Minor/Significance Unknown. Biotin supplementation may be necessary.brimonidinebrimonidine increases effects of lorazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.cisatracuriumlorazepam decreases effects of cisatracurium by pharmacodynamic antagonism. Minor/Significance Unknown.cyanocobalaminlorazepam decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.dexmethylphenidatedexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor/Significance Unknown.esomeprazoleesomeprazole increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.eucalyptuslorazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fleroxacinfleroxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.green teagreen tea decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.levocarnitinelorazepam decreases levels of levocarnitine by unspecified interaction mechanism. Minor/Significance Unknown.levofloxacinlevofloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.omeprazoleomeprazole increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.onabotulinumtoxinAlorazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Minor/Significance Unknown.pancuroniumlorazepam decreases effects of pancuronium by pharmacodynamic antagonism. Minor/Significance Unknown.pyrimethaminelorazepam, pyrimethamine. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hepatotoxicity.rapacuroniumlorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of lorazepam by increasing metabolism. Minor/Significance Unknown.rocuroniumlorazepam decreases effects of rocuronium by pharmacodynamic antagonism. Minor/Significance Unknown.sagelorazepam and sage both increase sedation. Minor/Significance Unknown.sage decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.serdexmethylphenidate/dexmethylphenidateserdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor/Significance Unknown.succinylcholinelorazepam decreases effects of succinylcholine by pharmacodynamic antagonism. Minor/Significance Unknown.vecuroniumlorazepam decreases effects of vecuronium by pharmacodynamic antagonism. Minor/Significance Unknown.vinpocetinelorazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).zolpidemzolpidem, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.acetaminophenMinor (1)lorazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen IVMinor (1)lorazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen rectalMinor (1)lorazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acrivastineMonitor Closely (1)acrivastine and lorazepam both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)lorazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)lorazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and lorazepam both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and lorazepam both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)lorazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and lorazepam both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)lorazepam and amoxapine both increase sedation. Use Caution/Monitor.apomorphineMonitor Closely (1)lorazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)lorazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use