for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.solifenacinsolifenacin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.St John's WortSt John's Wort will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and St John's Wort both increase serotonin levels. Avoid or Use Alternate Drug.sunitinibsunitinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.tacrolimustacrolimus and trazodone both increase QTc interval. Avoid or Use Alternate Drug.tedizolidtedizolid, trazodone. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. both increase serotonin levels; increased risk of serotonin syndrome.terbutalinetrazodone, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.tetrabenazinetetrabenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.thioridazinethioridazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.tipranavirtipranavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.toremifenetrazodone and toremifene both increase QTc interval. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.trifluoperazinetrifluoperazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trimipraminetrazodone and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.trazodone and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.tucatinibtucatinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose according to product labeling.venlafaxinetrazodone and venlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.vilazodonetrazodone, vilazodone. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated.voriconazolevoriconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.vorinostatvorinostat and trazodone both increase QTc interval. Avoid or Use Alternate Drug.vortioxetinetrazodone increases toxicity of vortioxetine by serotonin levels. Avoid or Use Alternate Drug.voxelotorvoxelotor will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid.xylometazolinetrazodone, xylometazoline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.yohimbeyohimbe, trazodone. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.yohimbinetrazodone, yohimbine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ziprasidonetrazodone and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (424)5-HTPtrazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.aceclofenactrazodone, aceclofenac. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.acemetacintrazodone, acemetacin. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.aclidiniumaclidinium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.acrivastineacrivastine and trazodone both increase sedation. Use Caution/Monitor.albuteroltrazodone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and trazodone both increase QTc interval. Use Caution/Monitor.alfentanilalfentanil and trazodone both increase sedation. Use Caution/Monitor.aliskirentrazodone will decrease the level or effect of aliskiren by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.almotriptanalmotriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.alprazolamalprazolam and trazodone both increase sedation. Use Caution/Monitor.amikacintrazodone will decrease the level or effect of amikacin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.amisulprideamisulpride and trazodone both increase sedation. Use Caution/Monitor.amitriptylinetrazodone will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.amitriptyline and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.amitriptyline and trazodone both increase sedation. Use Caution/Monitor.amobarbitalamobarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.amobarbital and trazodone both increase sedation. Use Caution/Monitor.amoxapineamoxapine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and trazodone both increase sedation. Use Caution/Monitor.apomorphinetrazodone and apomorphine both increase sedation. Use Caution/Monitor.aprepitantaprepitant will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.arformoteroltrazodone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and trazodone both increase QTc interval. Use Caution/Monitor.aripiprazolearipiprazole and trazodone both increase sedation. Use Caution/Monitor.armodafinilarmodafinil will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.artemether/lumefantrineartemether/lumefantrine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.asenapineasenapine and trazodone both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and trazodone both increase sedation. Use Caution/Monitor.aspirintrazodone, aspirin. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.aspirin rectaltrazodone, aspirin rectal. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.aspirin/citric acid/sodium bicarbonatetrazodone, aspirin/citric acid/sodium bicarbonate. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.atazanaviratazanavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.atazanavir increases levels of trazodone by unspecified interaction mechanism. Use Caution/Monitor.atogepanttrazodone will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.atorvastatintrazodone will decrease the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.atracuriumatracurium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMatropine IV/IM and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.avapritinibtrazodone will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.avapritinib and trazodone both increase sedation. Use Caution/Monitor.axitinibtrazodone increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.azelastineazelastine and trazodone both increase sedation. Use Caution/Monitor.azithromycintrazodone and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenbaclofen and trazodone both increase sedation. Use Caution/Monitor.bazedoxifene/conjugated estrogenstrazodone will decrease the level or effect of bazedoxifene/conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.belladonna and opiumbelladonna and opium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opium and trazodone both increase sedation. Use Caution/Monitor.benperidolbenperidol and trazodone both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, trazodone. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.benzhydrocodone/acetaminophen and trazodone both increase sedation. Use Caution/Monitor.benzphetaminetrazodone increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexpiprazoletrazodone will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor.brexpiprazole and trazodone both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and trazodone both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and trazodone both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and trazodone both increase sedation. Use Caution/Monitor.budesonidebudesonide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of budesonide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.bupivacaine implanttrazodone, bupivacaine implant. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.buprenorphinebuprenorphine and trazodone both increase sedation. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and trazodone both increase sedation. Use Caution/Monitor.buprenorphine subdermal implanttrazodone, buprenorphine subdermal implant. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine subdermal implant and trazodone both increase sedation. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and trazodone both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectiontrazodone, buprenorphine, long-acting injection. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine, long-acting injection and trazodone both increase sedation. Use Caution/Monitor.butabarbitalbutabarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.butabarbital and trazodone both increase sedation. Use Caution/Monitor.butalbitalbutalbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.butalbital and trazodone both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and trazodone both increase sedation. Use Caution/Monitor.caffeinetrazodone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbamazepinecarbamazepine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor plasma levels when used concomitantlycarbinoxaminecarbinoxamine and trazodone both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and trazodone both increase sedation. Use Caution/Monitor.celecoxibtrazodone, celecoxib. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.chloral hydratechloral hydrate and trazodone both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and trazodone both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and trazodone both increase sedation. Use Caution/Monitor.chlorpromazinechlorpromazine and trazodone both increase sedation. Use Caution/Monitor.chlorzoxazonechlorzoxazone and trazodone both increase sedation. Use Caution/Monitor.choline magnesium trisalicylatetrazodone, choline magnesium trisalicylate. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.cimetidinecimetidine will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.cinnarizinecinnarizine and trazodone both increase sedation. Use Caution/Monitor.citalopramcitalopram and trazodone both increase serotonin levels. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.clemastineclemastine and trazodone both increase sedation. Use Caution/Monitor.clomipramineclomipramine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.clomipramine and trazodone both increase sedation. Use Caution/Monitor.clonazepamclonazepam and trazodone both increase sedation. Use Caution/Monitor.clorazepateclorazepate and trazodone both increase sedation. Use Caution/Monitor.clozapineclozapine and trazodone both increase sedation. Use Caution/Monitor.cobicistatcobicistat will increase the level or effect of trazodone by Other (see comment). Use Caution/Monitor. Trazodone is a substrate of CYP3A4 and CYP2D6; cobicistat inhibits CYP3A4 and CYP2D6 cocaine topicaltrazodone and cocaine topical both increase serotonin levels. Modify Therapy/Monitor Closely.codeinecodeine and trazodone both increase sedation. Use Caution/Monitor.conjugated estrogenstrazodone will decrease the level or effect of conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.conjugated estrogens, vaginaltrazodone will decrease the level or effect of conjugated estrogens, vaginal by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.cortisonecortisone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of cortisone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.crizotinibcrizotinib increases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A.crofelemercrofelemer increases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.cyclizinecyclizine and trazodone both increase sedation. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and trazodone both increase sedation. Use Caution/Monitor.cyclosporinecyclosporine will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.cyproheptadinecyproheptadine and trazodone both increase sedation. Use Caution/Monitor.dabrafenibdabrafenib will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.dantrolenedantrolene and trazodone both increase sedation. Use Caution/Monitor.daridorexanttrazodone and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance