monitor for respiratory depression and sedation.gadobenateMonitor Closely (1)gadobenate and doxepin both increase QTc interval. Use Caution/Monitor.galantamineMonitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.ganaxoloneMonitor Closely (1)doxepin and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinMonitor Closely (1)doxepin and gemifloxacin both increase QTc interval. Use Caution/Monitor.gemtuzumabMonitor Closely (1)doxepin and gemtuzumab both increase QTc interval. Use Caution/Monitor.gilteritinibMonitor Closely (1)doxepin and gilteritinib both increase QTc interval. Use Caution/Monitor.givosiranSerious - Use Alternative (1)givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.glasdegibSerious - Use Alternative (1)doxepin and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.glimepirideMinor (1)doxepin increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.glipizideMinor (1)doxepin increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.glyburideMinor (1)doxepin increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.glycopyrrolateMonitor Closely (2)glycopyrrolate and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin increases levels of glycopyrrolate by unknown mechanism. Use Caution/Monitor.glycopyrrolate inhaledMonitor Closely (2)glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor.glycopyrronium tosylate topicalMonitor Closely (1)glycopyrronium tosylate topical, doxepin. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.goserelinMonitor Closely (1)doxepin and goserelin both increase QTc interval. Use Caution/Monitor.granisetronMonitor Closely (1)doxepin and granisetron both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)granisetron, doxepin. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.guanfacineSerious - Use Alternative (1)doxepin decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.haloperidolMonitor Closely (1)haloperidol and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and haloperidol both increase QTc interval. Avoid or Use Alternate Drug. haloperidol will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.henbaneMonitor Closely (1)henbane and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.histrelinMonitor Closely (1)doxepin and histrelin both increase QTc interval. Use Caution/Monitor.homatropineMonitor Closely (1)homatropine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine AMonitor Closely (1)huperzine A increases and doxepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydrocodoneMonitor Closely (1)hydrocodone, doxepin. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.hydromorphoneMonitor Closely (1)hydromorphone and doxepin both increase sedation. Use Caution/Monitor.hydroxychloroquine sulfateSerious - Use Alternative (1)doxepin and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.hydroxyprogesterone caproate (DSC)Minor (1)hydroxyprogesterone caproate (DSC), doxepin. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.hydroxyzineMonitor Closely (2)doxepin and hydroxyzine both increase QTc interval. Use Caution/Monitor. hydroxyzine and doxepin both increase sedation. Use Caution/Monitor.hyoscyamineMonitor Closely (1)hyoscyamine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.hyoscyamine sprayMonitor Closely (1)hyoscyamine spray and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.ibutilideContraindicated (1)doxepin and ibutilide both increase QTc interval. Contraindicated.iloperidoneMonitor Closely (3)doxepin and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely. iloperidone and doxepin both increase sedation. Use Caution/Monitor. iloperidone increases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imatinibMonitor Closely (1)imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.imipramineMonitor Closely (2)doxepin and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin and imipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and imipramine both increase QTc interval. Avoid or Use Alternate Drug. doxepin and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.indacaterol, inhaledMonitor Closely (1)indacaterol, inhaled, doxepin. QTc interval. Use Caution/Monitor. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias.indapamideContraindicated (1)doxepin and indapamide both increase QTc interval. Contraindicated.inotuzumabSerious - Use Alternative (1)doxepin and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.insulin aspartMinor (1)doxepin increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.insulin detemirMinor (1)doxepin increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.insulin glargineMinor (1)doxepin increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.insulin glulisineMinor (1)doxepin increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.insulin lisproMinor (1)doxepin increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.insulin NPHMinor (1)doxepin increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.insulin regular humanMinor (1)doxepin increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.iobenguane I 123Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Contraindicated. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results.iobenguane I 131Serious - Use Alternative (1)doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.ipratropiumMonitor Closely (1)ipratropium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.isocarboxazidContraindicated (1)isocarboxazid and doxepin both increase serotonin levels. Contraindicated.isofluraneMonitor Closely (1)doxepin and isoflurane both increase QTc interval. Use Caution/Monitor.isoniazidMonitor Closely (1)doxepin and isoniazid both increase serotonin levels. Modify Therapy/Monitor Closely.isoproterenolMonitor Closely (1)doxepin increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, isoproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)isoproterenol, doxepin. Mechanism: unknown. Minor/Significance Unknown. Risk of cardiac arrhythmias.istradefyllineMonitor Closely (1)istradefylline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleMonitor Closely (1)itraconazole and doxepin both increase QTc interval. Use Caution/Monitor.ivosidenibSerious - Use Alternative (1)doxepin and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.ketamineMonitor Closely (1)ketamine and doxepin both increase sedation. Use Caution/Monitor.Minor (1)ketamine, doxepin. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.ketoconazoleSerious - Use Alternative (1)doxepin and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.ketotifen, ophthalmicMonitor Closely (1)doxepin and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.L-tryptophanMonitor Closely (1)doxepin and L-tryptophan both increase serotonin levels. Modify Therapy/Monitor Closely.lapatinibMonitor Closely (1)doxepin and lapatinib both increase QTc interval. Modify Therapy/Monitor Closely.lasmiditanMonitor Closely (2)lasmiditan, doxepin. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. doxepin increases effects of lasmiditan by serotonin levels. Use Caution/Monitor. Coadministration may increase risk of serotonin syndrome.lefamulinContraindicated (1)lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.Monitor Closely (1)doxepin and lefamulin both increase QTc interval. Use Caution/Monitor.lemborexantMonitor Closely (1)lemborexant, doxepin. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lenvatinibSerious - Use Alternative (1)doxepin and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.leuprolideMonitor Closely (1)doxepin and leuprolide both increase QTc interval. Use Caution/Monitor.levalbuterolMonitor Closely (2)doxepin increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. doxepin and levalbuterol both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.levofloxacinMonitor Closely (1)doxepin and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levoketoconazoleSerious - Use Alternative (1)doxepin and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranSerious - Use Alternative (1)levomilnacipran and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.levorphanolMonitor Closely (1)levorphanol and doxepin both increase sedation. Use Caution/Monitor.levothyroxineMonitor Closely (1)levothyroxine increases effects of doxepin by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.linezolidSerious - Use Alternative (1)linezolid and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.liothyronineMonitor Closely (1)liothyronine increases effects of doxepin by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.liotrixMonitor Closely (1)liotrix increases effects of doxepin by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.lisdexamfetamineMonitor Closely (2)doxepin, lisdexamfetamine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). doxepin increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, lisdexamfetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lithiumMonitor Closely (2)doxepin and lithium both increase QTc interval. Use Caution/Monitor. doxepin and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.Minor (1)lithium, doxepin. Other (see comment). Minor/Significance Unknown. Comment: Risk of neurotoxicity in geriatric pts. Multiple mechanisms involved.lofepramineMonitor Closely (2)doxepin and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin and lofepramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and lofepramine both increase QTc interval. Avoid or Use Alternate Drug. doxepin and lofepramine both increase serotonin levels. Avoid or Use Alternate Drug.lofexidineMonitor Closely (3)doxepin decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. doxepin and lofexidine both increase QTc interval. Use Caution/Monitor. doxepin and lofexidine both increase sedation. Use Caution/Monitor.loperamideMonitor Closely (1)doxepin and loperamide both increase QTc interval. Use Caution/Monitor.lopinavirSerious - Use Alternative (1)doxepin and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.loprazolamMonitor Closely (1)loprazolam and doxepin both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam and doxepin both increase sedation. Use Caution/Monitor.lorcaserinMonitor Closely (1)lorcaserin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.lormetazepamMonitor Closely (1)lormetazepam and doxepin both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)loxapine and doxepin both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)loxapine inhaled and doxepin both increase sedation. Use Caution/Monitor.lsdMonitor Closely (1)doxepin and lsd both increase serotonin levels. Modify Therapy/Monitor Closely.lumefantrineSerious - Use Alternative (2)doxepin and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug. lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.lurasidoneMonitor Closely (1)lurasidone increases effects of doxepin by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of hypotension with concurrent use. Monitor blood pressure and adjust dose of antihypertensive agent as needed.macimorelinSerious - Use Alternative (1)doxepin and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.maprotilineMonitor Closely (2)doxepin and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin and maprotiline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. doxepin and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.maravirocMinor (1)maraviroc will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.marijuanaMonitor Closely (1)doxepin and marijuana both increase