and promethazine both increase QTc interval. Avoid or Use Alternate Drug.propofolpropofol increases levels of epinephrine by unknown mechanism. Avoid or Use Alternate Drug.propranololpropranolol increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).protriptylineepinephrine and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.protriptyline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.sevofluranesevoflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.thioridazineepinephrine and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.timololtimolol increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).trazodoneepinephrine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trifluoperazineepinephrine and trifluoperazine both increase QTc interval. Avoid or Use Alternate Drug.trimipramineepinephrine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.trimipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.yohimbeyohimbe, epinephrine. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.ziprasidoneepinephrine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (268)acebutololacebutolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acebutolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.aceclofenacaceclofenac increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinacemetacin increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterolalbuterol and epinephrine both decrease serum potassium. Use Caution/Monitor.albuterol and epinephrine both decrease sedation. Use Caution/Monitor.albuterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilalfentanil increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamalprazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amilorideamiloride increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amitriptylineamitriptyline increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.amobarbitalamobarbital increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineamoxapine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.arformoterolarformoterol and epinephrine both decrease serum potassium. Use Caution/Monitor.arformoterol and epinephrine both decrease sedation. Use Caution/Monitor.arformoterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.aripiprazolearipiprazole increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilepinephrine and armodafinil both decrease sedation. Use Caution/Monitor.aspirinaspirin increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalaspirin rectal increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololatenolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.atomoxetineatomoxetine, epinephrine. Other (see comment). Use Caution/Monitor. Comment: Due to the potential for increases in blood pressure and heart rate, atomoxetine should be used cautiously with vasopressors such as epinephrine.azelastineazelastine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.azithromycinepinephrine and azithromycin both increase QTc interval. Use Caution/Monitor.belladonna and opiumbelladonna and opium increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazideepinephrine and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.benperidolbenperidol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetamineepinephrine and benzphetamine both decrease sedation. Use Caution/Monitor.epinephrine and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.betaxololbetaxolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.betaxolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.bisoprololbisoprolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.bretyliumbretylium increases effects of epinephrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely. If catecholamines are administered to treat systolic BP <75 mmHg, a dilute solution should be employed and blood pressure monitored closely. Bretylium causes an initial norepinephrine release and may enhance catecholamine pressor effects.bromocriptinebromocriptine, epinephrine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Hypertension, V tach.brompheniraminebrompheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanideepinephrine and bumetanide both decrease serum potassium. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butabarbitalbutabarbital increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalbutalbital increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolbutorphanol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeineepinephrine and caffeine both decrease sedation. Use Caution/Monitor.carbenoxoloneepinephrine and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxaminecarbinoxamine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolcarvedilol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.celecoxibcelecoxib increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprololceliprolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.chloral hydratechloral hydrate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorothiazideepinephrine and chlorothiazide both decrease serum potassium. Use Caution/Monitor.chlorpheniraminechlorpheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazinechlorpromazine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazine, epinephrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.chlorpromazine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia.chlorthalidoneepinephrine and chlorthalidone both decrease serum potassium. Use Caution/Monitor.choline magnesium trisalicylatecholine magnesium trisalicylate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .cinnarizinecinnarizine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clemastineclemastine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineclomipramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.clonazepamclonazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clorazepateclorazepate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineclozapine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia.codeinecodeine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclizinecyclizine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclopenthiazideepinephrine and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.cyproheptadinecyproheptadine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.deflazacortepinephrine and deflazacort both decrease serum potassium. Use Caution/Monitor.desipraminedesipramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.desipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluramineepinephrine and dexfenfluramine both decrease sedation. Use Caution/Monitor.epinephrine and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidinedexmedetomidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidateepinephrine and dexmethylphenidate both decrease sedation. Use Caution/Monitor.epinephrine and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetamineepinephrine and dextroamphetamine both decrease sedation. Use Caution/Monitor.epinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramidedextromoramide increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphinediamorphine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dichlorphenamidedichlorphenamide and epinephrine both decrease serum potassium. Use Caution/Monitor.dichlorphenamide, epinephrine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diclofenacdiclofenac increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.diethylpropionepinephrine and diethylpropion both decrease sedation. Use Caution/Monitor.epinephrine and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.difenoxin hcldifenoxin hcl increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diflunisaldiflunisal increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.digoxindigoxin increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.dimenhydrinatedimenhydrinate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenhydraminediphenhydramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenoxylate hcldiphenoxylate hcl increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dipipanonedipipanone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dobutaminedobutamine and epinephrine both decrease serum potassium. Use Caution/Monitor.dobutamine and epinephrine both decrease sedation. Use Caution/Monitor.dobutamine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dolasetronepinephrine and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.dopamineepinephrine and dopamine both decrease sedation. Use Caution/Monitor.epinephrine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexaminedopexamine and epinephrine both decrease serum potassium. Use Caution/Monitor.dopexamine and epinephrine both decrease sedation. Use Caution/Monitor.dopexamine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexamine, epinephrine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.doxepindoxepin increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepin increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.droperidoldroperidol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.drospirenonedrospirenone increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.droxidopaepinephrine and droxidopa both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. May increase risk for supine hypertensionentacaponeentacapone will increase the level or effect of epinephrine by decreasing metabolism. Use Caution/Monitor. Entacapone is a COMT inhibitor. Caution if coadministered with drugs metabolized by COMT. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure.ephedrineephedrine and epinephrine both decrease serum potassium. Use Caution/Monitor.ephedrine and epinephrine both decrease sedation. Use Caution/Monitor.ephedrine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.ephedrine, epinephrine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.epinephrine inhaledepinephrine, epinephrine inhaled. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrine racemicepinephrine and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.epinephrine and epinephrine racemic both decrease sedation. Use Caution/Monitor.epinephrine and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrine, epinephrine racemic. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely.esmololesmolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.esmolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.estazolamestazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethacrynic acidepinephrine and