If unavoidable, monitor for loss of therapeutic effect of sensitive CYP3A4 substrates.ondansetronpimozide and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.oxaliplatinoxaliplatin and pimozide both increase QTc interval. Contraindicated.pacritinibpacritinib will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.paliperidonepaliperidone and pimozide both increase QTc interval. Avoid or Use Alternate Drug.panobinostatpimozide and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.pexidartinibpexidartinib will decrease the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of pexidartinib (a CYP3A4 inducer) with sensitive CYP3A substrates may lead to serious therapeutic failures. If concomitant use is unavoidable, increase the CYP3A substrate dosage in accordance with approved product labeling.pimavanserinpimavanserin and pimozide both increase QTc interval. Avoid or Use Alternate Drug. Coadministration may increase the risk of QT prolongation and cardiac arrhythmia.pitolisantpimozide and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.posaconazolepimozide and posaconazole both increase QTc interval. Avoid or Use Alternate Drug.posaconazole increases levels of pimozide by decreasing metabolism. Contraindicated. Risk of QT interval prolongation.pramipexolepimozide decreases effects of pramipexole by pharmacodynamic antagonism. Contraindicated.primaquineprimaquine and pimozide both increase QTc interval. Contraindicated.propafenonepropafenone, pimozide. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of prolonged QTc interval.quinupristin/dalfopristinquinupristin/dalfopristin increases levels of pimozide by decreasing metabolism. Contraindicated. Risk of QT interval prolongation.ranolazinepimozide and ranolazine both increase QTc interval. Avoid or Use Alternate Drug.ribociclibribociclib and pimozide both increase QTc interval. Avoid or Use Alternate Drug.ribociclib will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.risperidonepimozide and risperidone both increase QTc interval. Avoid or Use Alternate Drug.romidepsinpimozide and romidepsin both increase QTc interval. Avoid or Use Alternate Drug.ropinirolepimozide decreases effects of ropinirole by pharmacodynamic antagonism. Contraindicated.rucaparibrucaparib will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.safinamidepimozide decreases effects of safinamide by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Dopamine antagonists may decrease safinamide effects and exacerbate Parkinson disease symptoms.saquinavirsaquinavir increases levels of pimozide by decreasing metabolism. Contraindicated. Risk of prolonged QTc interval.saquinavir will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.selinexorselinexor, pimozide. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sertralinesertraline and pimozide both increase QTc interval. Contraindicated.sevofluranesevoflurane and pimozide both increase QTc interval. Contraindicated.siponimodsiponimod and pimozide both increase QTc interval. Contraindicated.sodium oxybatepimozide, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.solifenacinsolifenacin and pimozide both increase QTc interval. Contraindicated.sotorasibsotorasib will decrease the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If use is unavoidable, refer to the prescribing information of the CYP3A4 substrate for dosage modificationssufentanil SLsufentanil SL, pimozide. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.sulfamethoxazolesulfamethoxazole and pimozide both increase QTc interval. Avoid or Use Alternate Drug.sunitinibsunitinib and pimozide both increase QTc interval. Contraindicated.tacrolimustacrolimus and pimozide both increase QTc interval. Contraindicated.telavancinpimozide and telavancin both increase QTc interval. Avoid or Use Alternate Drug.tetrabenazinetetrabenazine and pimozide both increase QTc interval. Contraindicated.tipranavirtipranavir will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.trimethoprimpimozide and trimethoprim both increase QTc interval. Avoid or Use Alternate Drug.triptorelintriptorelin increases toxicity of pimozide by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.tropisetronpimozide and tropisetron both increase QTc interval. Avoid or Use Alternate Drug.tucatinibtucatinib will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose according to product labeling.umeclidinium bromide/vilanterol inhaledpimozide increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vandetanibpimozide, vandetanib. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.venlafaxinepimozide and venlafaxine both increase QTc interval. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaledpimozide increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.voriconazolepimozide and voriconazole both increase QTc interval. Avoid or Use Alternate Drug.vorinostatvorinostat and pimozide both increase QTc interval. Contraindicated.voxelotorvoxelotor will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid.zafirlukastzafirlukast increases levels of pimozide by decreasing metabolism. Contraindicated. Risk of QT interval prolongation.zileutonzileuton increases levels of pimozide by decreasing metabolism. Contraindicated. May prolong QTc interval.Monitor Closely (344)abobotulinumtoxinAabobotulinumtoxinA increases effects of pimozide by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects.aclidiniumaclidinium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.acrivastineacrivastine and pimozide both increase sedation. Use Caution/Monitor.albuterolpimozide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilalfentanil and pimozide both increase sedation. Use Caution/Monitor.alfuzosinpimozide and alfuzosin both increase QTc interval. Use Caution/Monitor.almotriptanalmotriptan, pimozide. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).alprazolamalprazolam and pimozide both increase sedation. Use Caution/Monitor.amifampridinepimozide increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.amitriptylinepimozide and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and pimozide both increase sedation. Use Caution/Monitor.amoxapinepimozide and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely.pimozide and amoxapine both increase sedation. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.anticholinergic/sedative combos decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.arformoterolpimozide increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazolearipiprazole and pimozide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.aripiprazole and pimozide both increase sedation. Use Caution/Monitor.armodafinilpimozide increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineasenapine and pimozide both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and pimozide both increase sedation. Use Caution/Monitor.atogepantpimozide will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.atracuriumatracurium decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atracurium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of atracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropineatropine decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of atropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IMpimozide increases effects of atropine IV/IM by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IM decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine IV/IM decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.avapritinibpimozide will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.avapritinib and pimozide both increase sedation. Use Caution/Monitor.axitinibpimozide increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.azelastineazelastine and pimozide both increase sedation. Use Caution/Monitor.azithromycinazithromycin and pimozide both increase QTc interval. Modify Therapy/Monitor Closely.baclofenbaclofen and pimozide both increase sedation. Use Caution/Monitor.bedaquilinepimozide and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsbelladonna alkaloids decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna alkaloids decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of belladonna alkaloids by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.belladonna and opiumbelladonna and opium and pimozide both increase sedation. Use Caution/Monitor.belladonna and opium decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna and opium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of belladonna and opium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benperidolbenperidol and pimozide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.benperidol and pimozide both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen and pimozide both increase sedation. Use Caution/Monitor.benzphetaminepimozide increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benztropinepimozide increases effects of benztropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. .berotralstatberotralstat will increase the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor or titrate substrate dose when berotralstat is coadministered with narrow therapeutic index drugs that are CYP3A substrates.brexanolonebrexanolone, pimozide. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and pimozide both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and pimozide both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and pimozide both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and pimozide both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and pimozide both increase sedation. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and pimozide both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and pimozide both increase sedation. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and pimozide both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionpimozide increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.buprenorphine, long-acting injection and pimozide both increase sedation. Use Caution/Monitor.butabarbitalbutabarbital and pimozide both increase sedation. Use Caution/Monitor.butalbitalbutalbital and pimozide both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and pimozide both increase sedation. Use Caution/Monitor.caffeinepimozide increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cannabidiolcannabidiol, pimozide. affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Owing to the potential for both CYP1A2 induction and inhibition with the coadministration of CYP1A2 substrates and cannabidiol, consider reducing dosage adjustment of CYP1A2 substrates as clinically appropriate.carbamazepinecarbamazepine will decrease the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.carbinoxaminecarbinoxamine and pimozide both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and pimozide both increase sedation. Use Caution/Monitor.cenobamatecenobamate will decrease the level or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.cenobamate, pimozide. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydratechloral hydrate and pimozide both increase