AdultPediatricGeriatricDosage Forms & Strengths tablet: Schedule IV 200mg 400mg Anxiety 1200-1600 mg/day PO divided q6-8hr; not to exceed 2.4 g/day Preoperative Sedation 400 mg PO before the procedure Renal Impairment CrCl 10-50 mL/min: Change frequency of administration to every 9-12hr CrCl <10 mL/min: Change frequency of administration to 12-18hr Hepatic Impairment Use cautionDosage Forms & Strengths tablet: Schedule IV 200mg 400mg Anxiety <6 years old: Not recommended 6-12 years old: 100-200 mg PO q8-12hr >12 years old: 1200-1600 mg/day PO divided q8-12hr; not to exceed 2.4 g/day Preoperative Sedation 200 mg PO prior to procedureNot drug of choice in elderly because of potential physical and psychological dependence Use lowest effective dose to avoid oversedation Anxiety Lower initial dose; adjust more gradually; 200 mg PO q8-12hrInteraction CheckerEnter a drug name and meprobamateNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (7)benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.calcium/magnesium/potassium/sodium oxybatesmeprobamate, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydrocodonehydrocodone, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.metoclopramide intranasalmeprobamate, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olopatadine intranasalmeprobamate and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. sodium oxybatemeprobamate, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.sufentanil SLsufentanil SL, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.Monitor Closely (187)acrivastineacrivastine and meprobamate both increase sedation. Use Caution/Monitor.albuterolmeprobamate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilalfentanil and meprobamate both increase sedation. Use Caution/Monitor.alprazolamalprazolam and meprobamate both increase sedation. Use Caution/Monitor.amitriptylineamitriptyline and meprobamate both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and meprobamate both increase sedation. Use Caution/Monitor.amoxapineamoxapine and meprobamate both increase sedation. Use Caution/Monitor.apomorphineapomorphine and meprobamate both increase sedation. Use Caution/Monitor.arformoterolmeprobamate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazolearipiprazole and meprobamate both increase sedation. Use Caution/Monitor.armodafinilmeprobamate increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineasenapine and meprobamate both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and meprobamate both increase sedation. Use Caution/Monitor.avapritinibavapritinib and meprobamate both increase sedation. Use Caution/Monitor.azelastineazelastine and meprobamate both increase sedation. Use Caution/Monitor.baclofenbaclofen and meprobamate both increase sedation. Use Caution/Monitor.belladonna and opiumbelladonna and opium and meprobamate both increase sedation. Use Caution/Monitor.benperidolbenperidol and meprobamate both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen and meprobamate both increase sedation. Use Caution/Monitor.benzphetaminemeprobamate increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanolonebrexanolone, meprobamate. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and meprobamate both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and meprobamate both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and meprobamate both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and meprobamate both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionmeprobamate increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.buprenorphine, long-acting injection and meprobamate both increase sedation. Use Caution/Monitor.butabarbitalbutabarbital and meprobamate both increase sedation. Use Caution/Monitor.butalbitalbutalbital and meprobamate both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and meprobamate both increase sedation. Use Caution/Monitor.caffeinemeprobamate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and meprobamate both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and meprobamate both increase sedation. Use Caution/Monitor.chloral hydratechloral hydrate and meprobamate both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and meprobamate both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.chlorpromazinechlorpromazine and meprobamate both increase sedation. Use Caution/Monitor.chlorzoxazonechlorzoxazone and meprobamate both increase sedation. Use Caution/Monitor.cinnarizinecinnarizine and meprobamate both increase sedation. Use Caution/Monitor.clemastineclemastine and meprobamate both increase sedation. Use Caution/Monitor.clobazammeprobamate, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineclomipramine and meprobamate both increase sedation. Use Caution/Monitor.clonazepamclonazepam and meprobamate both increase sedation. Use Caution/Monitor.clorazepateclorazepate and meprobamate both increase sedation. Use Caution/Monitor.clozapineclozapine and meprobamate both increase sedation. Use Caution/Monitor.codeinecodeine and meprobamate both increase sedation. Use Caution/Monitor.cyclizinecyclizine and meprobamate both increase sedation. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and meprobamate both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and meprobamate both increase sedation. Use Caution/Monitor.dantrolenedantrolene and meprobamate both increase sedation. Use Caution/Monitor.daridorexantmeprobamate and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desipraminedesipramine and meprobamate both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.dexfenfluraminemeprobamate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinedexmedetomidine and meprobamate both increase sedation. Use Caution/Monitor.dexmethylphenidatemeprobamate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminemeprobamate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramidedextromoramide and meprobamate both increase sedation. Use Caution/Monitor.diamorphinediamorphine and meprobamate both increase sedation. Use Caution/Monitor.diazepamdiazepam and meprobamate both increase sedation. Use Caution/Monitor.diethylpropionmeprobamate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and meprobamate both increase sedation. Use Caution/Monitor.difenoxin hcldifenoxin hcl and meprobamate both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and meprobamate both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and meprobamate both increase sedation. Use Caution/Monitor.diphenoxylate hcldiphenoxylate hcl and meprobamate both increase sedation. Use Caution/Monitor.dipipanonedipipanone and meprobamate both increase sedation. Use Caution/Monitor.dobutaminemeprobamate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopaminemeprobamate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexaminemeprobamate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepindoxepin and meprobamate both increase sedation. Use Caution/Monitor.doxylaminedoxylamine and meprobamate both increase sedation. Use Caution/Monitor.droperidoldroperidol and meprobamate both increase sedation. Use Caution/Monitor.ephedrinemeprobamate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrinemeprobamate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicmeprobamate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamestazolam and meprobamate both increase sedation. Use Caution/Monitor.ethanolethanol and meprobamate both increase sedation. Use Caution/Monitor.meprobamate, ethanol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive CNS depression.etomidateetomidate and meprobamate both increase sedation. Use Caution/Monitor.fenfluraminemeprobamate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluphenazinefluphenazine and meprobamate both increase sedation. Use Caution/Monitor.flurazepamflurazepam and meprobamate both increase sedation. Use Caution/Monitor.formoterolmeprobamate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentingabapentin, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxolonemeprobamate and ganaxolone both increase sedation. Use Caution/Monitor.haloperidolhaloperidol and meprobamate both increase sedation. Use Caution/Monitor.hydromorphonehydromorphone and meprobamate both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.iloperidoneiloperidone and meprobamate both increase sedation. Use Caution/Monitor.imipramineimipramine and meprobamate both increase sedation. Use Caution/Monitor.isoproterenolmeprobamate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineketamine and meprobamate both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, meprobamate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantlemborexant, meprobamate. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.levalbuterolmeprobamate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanollevorphanol and meprobamate both increase sedation. Use Caution/Monitor.lisdexamfetaminemeprobamate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepraminelofepramine and meprobamate both increase sedation. Use Caution/Monitor.lofexidinelofexidine and meprobamate both increase sedation. Use Caution/Monitor.loprazolamloprazolam and meprobamate both increase sedation. Use Caution/Monitor.lorazepamlorazepam and meprobamate both increase sedation. Use Caution/Monitor.lormetazepamlormetazepam and meprobamate both increase sedation. Use Caution/Monitor.loxapineloxapine and meprobamate both increase sedation. Use Caution/Monitor.loxapine inhaledloxapine inhaled and meprobamate both increase sedation. Use Caution/Monitor.lurasidonelurasidone, meprobamate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilinemaprotiline and meprobamate both increase sedation. Use Caution/Monitor.marijuanamarijuana and meprobamate both increase sedation. Use Caution/Monitor.melatoninmelatonin and meprobamate both increase sedation. Use Caution/Monitor.meperidinemeperidine and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolmeprobamate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonemetaxalone and meprobamate both increase sedation. Use Caution/Monitor.methadonemethadone and meprobamate both increase sedation. Use Caution/Monitor.methamphetaminemeprobamate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolmethocarbamol and meprobamate both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminemeprobamate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and meprobamate both increase sedation. Use Caution/Monitor.midodrinemeprobamate increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapinemeprobamate and mirtazapine both increase sedation. Use Caution/Monitor.modafinilmeprobamate increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinemorphine and meprobamate both increase sedation. Use Caution/Monitor.motherwortmeprobamate and motherwort both increase sedation. Use Caution/Monitor.moxonidinemeprobamate and moxonidine both increase sedation. Use Caution/Monitor.nabilonemeprobamate and nabilone both increase sedation. Use Caution/Monitor.nalbuphinenalbuphine and meprobamate both increase sedation. Use Caution/Monitor.norepinephrinemeprobamate increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinenortriptyline and meprobamate both increase sedation. Use Caution/Monitor.olanzapineolanzapine and meprobamate both increase sedation. Use Caution/Monitor.oliceridineoliceridine, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tinctureopium tincture and meprobamate both increase sedation. Use Caution/Monitor.orphenadrineorphenadrine and meprobamate both increase sedation. Use Caution/Monitor.oxazepamoxazepam and meprobamate both increase sedation. Use Caution/Monitor.oxycodoneoxycodone and meprobamate both increase sedation. Use