both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)temazepam and codeine both increase sedation. Use Caution/Monitor.cyclizineMonitor Closely (1)cyclizine and temazepam both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)temazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and temazepam both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)temazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)temazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluraneMonitor Closely (1)desflurane and temazepam both increase sedation. Use Caution/Monitor.desipramineMonitor Closely (1)temazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)temazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)temazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)temazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)temazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)temazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)temazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)temazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and temazepam both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionMonitor Closely (1)temazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and temazepam both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)temazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and temazepam both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and temazepam both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)temazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)temazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineMonitor Closely (1)temazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)temazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)temazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)temazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)temazepam and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)temazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)temazepam and droperidol both increase sedation. Use Caution/Monitor.ephedrineMonitor Closely (1)temazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)temazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)temazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)esketamine intranasal, temazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamMonitor Closely (1)estazolam and temazepam both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (1)temazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and temazepam both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)temazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fenfluramineMonitor Closely (1)temazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fentanylSerious - Use Alternative (1)fentanyl, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalSerious - Use Alternative (1)fentanyl intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalSerious - Use Alternative (1)fentanyl transdermal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalSerious - Use Alternative (1)fentanyl transmucosal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fleroxacinMinor (1)fleroxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.flibanserinMonitor Closely (1)temazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineMonitor Closely (1)temazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam and temazepam both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)temazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentinMonitor Closely (1)gabapentin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)temazepam and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinMinor (1)gemifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.green teaMinor (1)green tea decreases effects of temazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.haloperidolMonitor Closely (1)temazepam and haloperidol both increase sedation. Use Caution/Monitor.hydrocodoneSerious - Use Alternative (1)hydrocodone, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)temazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and temazepam both increase sedation. Use Caution/Monitor.iloperidoneMonitor Closely (1)temazepam and iloperidone both increase sedation. Use Caution/Monitor.imipramineMonitor Closely (1)temazepam and imipramine both increase sedation. Use Caution/Monitor.isoproterenolMonitor Closely (1)temazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineMonitor Closely (1)ketamine and temazepam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicMonitor Closely (1)temazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanMonitor Closely (1)lasmiditan, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantSerious - Use Alternative (1)lemborexant, temazepam. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.levalbuterolMonitor Closely (1)temazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levofloxacinMinor (1)levofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.levonorgestrel oral/ethinylestradiol/ferrous bisglycinateMonitor Closely (1)levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will decrease the level or effect of temazepam by unknown mechanism. Use Caution/Monitor.levorphanolMonitor Closely (1)temazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)temazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineMonitor Closely (1)temazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineMonitor Closely (1)temazepam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamMonitor Closely (1)loprazolam and temazepam both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam and temazepam both increase sedation. Use Caution/Monitor.lormetazepamMonitor Closely (1)lormetazepam and temazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)temazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)temazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.maprotilineMonitor Closely (1)temazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)temazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninMonitor Closely (1)temazepam and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)temazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)temazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)temazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)temazepam and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)temazepam and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)temazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)temazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)temazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metoclopramide intranasalSerious - Use Alternative (1)temazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midazolamMonitor Closely (1)midazolam and temazepam both increase sedation. Use Caution/Monitor.midazolam intranasalMonitor Closely (1)midazolam intranasal, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineMonitor Closely (1)temazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineMonitor Closely (1)temazepam and mirtazapine both increase sedation. Use Caution/Monitor.modafinilMonitor Closely (1)temazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineMonitor Closely (1)temazepam and morphine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)temazepam and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinMinor (1)moxifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.moxonidineMonitor Closely (1)temazepam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)temazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphineMonitor Closely (1)temazepam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrineMonitor Closely (1)temazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineMonitor Closely (1)temazepam and nortriptyline both increase sedation. Use Caution/Monitor.ofloxacinMinor (1)ofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.olanzapineMonitor Closely (1)temazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (1)oliceridine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olopatadine intranasalSerious - Use Alternative (1)temazepam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. opium tinctureMonitor Closely (1)temazepam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineMonitor Closely (1)temazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamMonitor Closely (1)oxazepam and temazepam both increase sedation. Use Caution/Monitor.oxycodoneMonitor Closely (1)temazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneMonitor Closely (1)temazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneMonitor Closely (1)temazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumMonitor Closely (1)temazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverineMonitor Closely (1)temazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocineMonitor Closely (1)temazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and temazepam both increase sedation. Use Caution/Monitor.perphenazineMonitor Closely (1)temazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineMonitor Closely (1)temazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (1)phenobarbital and temazepam both increase sedation. Use Caution/Monitor.phentermineMonitor Closely (1)temazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (1)temazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (1)temazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineMonitor Closely (1)temazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozideMonitor Closely (1)temazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)temazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinMonitor Closely (1)pregabalin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneMonitor Closely (1)primidone and temazepam both increase sedation. Use Caution/Monitor.prochlorperazineMonitor Closely (1)temazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineMonitor Closely (1)promethazine and temazepam both increase sedation. Use Caution/Monitor.propofolMonitor Closely (1)propofol and temazepam both increase sedation. Use Caution/Monitor.propylhexedrineMonitor Closely (1)temazepam increases and