AdultPediatricDosage Forms & Strengths tablet 5mg (VESIcare) 10mg (VESIcare) Overactive Bladder VESIcare only Indicated for treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency 5 mg PO qDay, may increase to 10 mg/day if well tolerated Dosing Modifications Renal impairment Mild-to-moderate (CrCl ≥30 mL/min): No dosage adjustment necessary Severe (CrCl <30 mL/min): Not to exceed 5 mg/day Hepatic impairment Mild (Child-Pugh A): No dosage adjustment necessary Moderate (Child-Pugh B): Not to exceed 5 mg/day Severe (Child-Pugh class C): Not recommended CYP3A4 inhibitors Coadministration with strong CYP3A4 (eg, ketoconazole): Solifenacin dose not to exceed 5 mg/day Dosage Forms & Strengths oral suspension 1mg/mL (VESIcare LS) Neurogenic Detrusor Overactivity VESIcare LS only Indicated for treatment of neurogenic detrusor overactivity (NDO) in pediatric patients aged ≥2 years <2 years: Safety and efficacy not established ≥2 years Oral suspension concentration 1 mg/mL 9 to 15 kg: 2 mL PO qDay initially; not to exceed 4 mL/day >15 to 30 kg: 3 mL PO qDay initially; not to exceed 5 mL/day >30 to 45 kg: 3 mL PO qDay initially; not to exceed 6 mL/day >45 to 60 kg: 4 mL PO qDay initially; not to exceed 8 mL/day >60 kg: 5 mL PO qDay initially; not to exceed 10 mL/day Dosage Modifications Renal impairment Mild-to-moderate (CrCl ≥30 mL/min): No dosage adjustment necessary Severe (CrCl <30 mL/min): Not to exceed starting dose for weight range Hepatic impairment Mild (Child-Pugh A): No dosage adjustment necessary Moderate (Child-Pugh B): Not to exceed starting dose for weight range Severe (Child-Pugh class C): Not recommended Strong CYP3A4 inhibitors Coadministration with strong CYP3A4 (eg, ketoconazole): Solifenacin dose not to exceed starting dose for weight range Interaction CheckerEnter a drug name and solifenacinNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (5)dronedaronesolifenacin and dronedarone both increase QTc interval. Contraindicated.fluconazolesolifenacin and fluconazole both increase QTc interval. Contraindicated.itraconazoleitraconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration in patients with renal or hepatic impairment may result in increased solifenacin levels and increased risk for potentially fatal adverse events.lefamulinlefamulin will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.thioridazinesolifenacin and thioridazine both increase QTc interval. Contraindicated.Serious - Use Alternative (95)abametapirabametapir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.adagrasibadagrasib, solifenacin. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.amiodaronesolifenacin and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.anagrelidesolifenacin and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.apalutamideapalutamide will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.arsenic trioxidesolifenacin and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinesolifenacin and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapinesolifenacin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphinesolifenacin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalbuprenorphine transdermal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.carbamazepinecarbamazepine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.ceritinibceritinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.ceritinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chlorpromazinesolifenacin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.cimetidinecimetidine will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.citalopramcitalopram and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinclarithromycin will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.clarithromycin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.cobicistatcobicistat will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.crizotinibcrizotinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.desfluranedesflurane and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.dofetilidedofetilide increases toxicity of solifenacin by QTc interval. Avoid or Use Alternate Drug.donepezildonepezil and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.droperidolsolifenacin and droperidol both increase QTc interval. Avoid or Use Alternate Drug.eliglustatsolifenacin and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.encorafenibencorafenib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.entrectinibentrectinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.eribulineribulin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseerythromycin base will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.solifenacin and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateerythromycin ethylsuccinate will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.solifenacin and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateerythromycin lactobionate will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.solifenacin and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateerythromycin stearate will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.solifenacin and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.fexinidazolefexinidazole and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.foscarnetsolifenacin and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.glasdegibsolifenacin and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.glycopyrronium tosylate topicalglycopyrronium tosylate topical, solifenacin. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.hydroxychloroquine sulfatehydroxychloroquine sulfate and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.ibutilidesolifenacin and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.idelalisibidelalisib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substratesiloperidonesolifenacin and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabsolifenacin and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.isofluraneisoflurane and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.itraconazoleitraconazole and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ivosidenib will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.ketoconazoleketoconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Do not exceed a 5 mg/day dosage of solifenacin when concomitantly used with strong CYP3A4 inhibitors.lefamulinsolifenacin and lefamulin both increase QTc interval. Avoid or Use Alternate Drug.lenvatinibsolifenacin and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.levoketoconazolelevoketoconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Do not exceed a 5 mg/day dosage of solifenacin when concomitantly used with strong CYP3A4 inhibitors.lonafarniblonafarnib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.lopinavirlopinavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.solifenacin and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilinesolifenacin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.mefloquinemefloquine increases toxicity of solifenacin by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.methadonesolifenacin and methadone both increase QTc interval. Avoid or Use Alternate Drug.midostaurinsolifenacin and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibmobocertinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.nefazodonenefazodone will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.ondansetronondansetron and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.oxaliplatinoxaliplatin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.paliperidonesolifenacin and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.panobinostatsolifenacin and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.pentamidinesolifenacin and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.pimavanserinsolifenacin and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.pimozidesolifenacin and pimozide both increase QTc interval. Contraindicated.pitolisantsolifenacin and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodsolifenacin and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.posaconazolesolifenacin and posaconazole both increase QTc interval. Contraindicated.pramlintidepramlintide, solifenacin. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.propafenonesolifenacin and propafenone both increase QTc interval. Avoid or Use Alternate Drug.quetiapinesolifenacin and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.revefenacinrevefenacin and solifenacin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.ribociclibribociclib increases toxicity of solifenacin by QTc interval. Avoid or Use Alternate Drug.rifabutinrifabutin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifampinrifampin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.saquinavirsaquinavir increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potential for increased toxicity. Increased risk of PR or QT prolongation and cardiac arrhythmias.solifenacin and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.secretinsolifenacin decreases effects of secretin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Concomitant use of anticholinergic drugs may cause a hyporesponse to stimulation testing with secretin. Discontinue anticholinergic drugs at least 5 half-lives before administering secretin.sevofluranesevoflurane and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.siponimodsiponimod and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.solifenacin and siponimod both increase QTc interval. Avoid or Use Alternate Drug.sotalolsolifenacin and sotalol both increase QTc interval. Avoid or Use Alternate Drug.St John's WortSt John's Wort will decrease the