clear, use caution. Use Caution/Monitor.saquinavirsaquinavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.scullcapflurazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and flurazepam both increase sedation. Use Caution/Monitor.sevofluranesevoflurane and flurazepam both increase sedation. Use Caution/Monitor.shepherd's purseflurazepam and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, flurazepam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.stiripentol, flurazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanilflurazepam and sufentanil both increase sedation. Use Caution/Monitor.tapentadolflurazepam and tapentadol both increase sedation. Use Caution/Monitor.tazemetostattazemetostat will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tecovirimattecovirimat will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.temazepamflurazepam and temazepam both increase sedation. Use Caution/Monitor.terbutalineflurazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineflurazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixeneflurazepam and thiothixene both increase sedation. Use Caution/Monitor.tipranavirtipranavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.topiramateflurazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolflurazepam and tramadol both increase sedation. Use Caution/Monitor.trazodoneflurazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamflurazepam and triazolam both increase sedation. Use Caution/Monitor.triclofosflurazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazineflurazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipramineflurazepam and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and flurazepam both increase sedation. Use Caution/Monitor.voriconazolevoriconazole will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.xylometazolineflurazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbineflurazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotideflurazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneflurazepam and ziprasidone both increase sedation. Use Caution/Monitor.zotepineflurazepam and zotepine both increase sedation. Use Caution/Monitor.Minor (19)acetazolamideacetazolamide will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anastrozoleanastrozole will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.brimonidinebrimonidine increases effects of flurazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.ciprofloxacinciprofloxacin increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.cyclophosphamidecyclophosphamide will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.esomeprazoleesomeprazole increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.eucalyptusflurazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fleroxacinfleroxacin increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.larotrectiniblarotrectinib will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.levofloxacinlevofloxacin increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.omeprazoleomeprazole increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of flurazepam by increasing metabolism. Minor/Significance Unknown.rifapentinerifapentine will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.sageflurazepam and sage both increase sedation. Minor/Significance Unknown.vinpocetineflurazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).zolpidemzolpidem, flurazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.abametapirSerious - Use Alternative (1)abametapir will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.acetazolamideMinor (1)acetazolamide will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.acrivastineMonitor Closely (1)acrivastine and flurazepam both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)flurazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)flurazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and flurazepam both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and flurazepam both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)flurazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and flurazepam both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)flurazepam and amoxapine both increase sedation. Use Caution/Monitor.anastrozoleMinor (1)anastrozole will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.apalutamideSerious - Use Alternative (1)apalutamide will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphineMonitor Closely (1)flurazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)flurazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)flurazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)flurazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and flurazepam both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and flurazepam both increase sedation. Use Caution/Monitor.atazanavirMonitor Closely (1)atazanavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.avapritinibMonitor Closely (1)avapritinib and flurazepam both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and flurazepam both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)flurazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)flurazepam and belladonna and opium both increase sedation. Use Caution/Monitor.belzutifanMonitor Closely (1)belzutifan will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information. benperidolMonitor Closely (1)flurazepam and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, flurazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and flurazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)flurazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bosentanMonitor Closely (1)bosentan will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, flurazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and flurazepam both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and flurazepam both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of flurazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and flurazepam both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and flurazepam both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)flurazepam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)flurazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)flurazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.Serious - Use Alternative (1)buprenorphine subdermal implant and flurazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and flurazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionMonitor Closely (1)flurazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.Serious - Use Alternative (1)buprenorphine, long-acting injection and flurazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)butabarbital and flurazepam both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and flurazepam both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)flurazepam and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)flurazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesContraindicated (1)flurazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.carbamazepineMonitor Closely (1)carbamazepine will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.carbinoxamineMonitor Closely (1)carbinoxamine and flurazepam both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)flurazepam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.ceritinibMonitor Closely (1)ceritinib will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.chloral hydrateMonitor Closely (1)flurazepam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and flurazepam both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and flurazepam both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)flurazepam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)flurazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and flurazepam both increase sedation. Use Caution/Monitor.ciprofloxacinMinor (1)ciprofloxacin increases levels of flurazepam by decreasing metabolism. Minor/Significance Unknown.clarithromycinMonitor Closely (1)clarithromycin will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.clemastineMonitor Closely (1)clemastine and flurazepam both increase sedation. Use Caution/Monitor.clomipramineMonitor Closely (1)flurazepam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and flurazepam both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, flurazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateMonitor Closely (1)clorazepate and flurazepam both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)flurazepam and clozapine both increase sedation. Use Caution/Monitor.cobicistatMonitor Closely (1)cobicistat will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.codeineMonitor Closely (1)flurazepam and codeine both increase sedation. Use Caution/Monitor.conivaptanSerious - Use Alternative (1)conivaptan will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.crizotinibMonitor Closely (1)crizotinib increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A.crofelemerMonitor Closely (1)crofelemer increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.cyclizineMonitor Closely (1)cyclizine and flurazepam both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)flurazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyclophosphamideMinor (1)cyclophosphamide will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.cyproheptadineMonitor Closely (1)cyproheptadine and flurazepam both increase sedation. Use Caution/Monitor.dabrafenibMonitor Closely (1)dabrafenib will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.dantroleneMonitor Closely (1)flurazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)flurazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darunavirMonitor Closely (1)darunavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.desfluraneMonitor Closely (1)desflurane and flurazepam both increase sedation. Use Caution/Monitor.desipramineMonitor Closely (1)flurazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)flurazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and flurazepam both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)flurazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely