Alternate Drug. isocarboxazid increases levels of frovatriptan by decreasing metabolism. Contraindicated.gabapentinMonitor Closely (1)gabapentin, isocarboxazid. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, isocarboxazid. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)isocarboxazid and ganaxolone both increase sedation. Use Caution/Monitor.glimepirideMonitor Closely (1)isocarboxazid increases effects of glimepiride by unknown mechanism. Use Caution/Monitor.glipizideMonitor Closely (1)isocarboxazid increases effects of glipizide by unknown mechanism. Use Caution/Monitor.glyburideMonitor Closely (1)isocarboxazid increases effects of glyburide by unknown mechanism. Use Caution/Monitor.granisetronSerious - Use Alternative (1)granisetron, isocarboxazid. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.green teaMonitor Closely (1)green tea, isocarboxazid. Other (see comment). Use Caution/Monitor. Comment: Avoid combination or excessive consumption of green tea. Combination may increase risk of cardiac arrhythmias or severe hypertension can occur due to caffeine component of green tea.hydralazineMonitor Closely (1)hydralazine, isocarboxazid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of hypertension.hydrochlorothiazideSerious - Use Alternative (1)isocarboxazid, hydrochlorothiazide. Other (see comment). Contraindicated. Comment: Additive hypotensive effects may be seen when MAOI's are combined with antihypertensives.hydrocodoneSerious - Use Alternative (1)isocarboxazid increases toxicity of hydrocodone by serotonin levels. Avoid or Use Alternate Drug. MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (eg, respiratory depression, coma). Opioids are not recommended for patients taking MAOIs or within 14 days of stopping MAOIs. If urgent opioid treatment needed, use test doses and frequent titration of small doses to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression.hydromorphoneSerious - Use Alternative (1)isocarboxazid increases toxicity of hydromorphone by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.hydroxyzineSerious - Use Alternative (1)isocarboxazid increases effects of hydroxyzine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .imipramineContraindicated (1)isocarboxazid and imipramine both increase serotonin levels. Contraindicated.indacaterol, inhaledMonitor Closely (1)indacaterol, inhaled, isocarboxazid. QTc interval. Use Caution/Monitor. Indacaterol should be administered with extreme caution to patients treated with MAO inhibitors. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias.indapamideSerious - Use Alternative (1)isocarboxazid, indapamide. Other (see comment). Contraindicated. Comment: Additive hypotensive effects may be seen when MAOI's are combined with antihypertensives.insulin aspartMonitor Closely (1)isocarboxazid increases effects of insulin aspart by unknown mechanism. Use Caution/Monitor.insulin degludecMonitor Closely (1)isocarboxazid, insulin degludec. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs decrease blood glucose.insulin degludec/insulin aspartMonitor Closely (1)isocarboxazid, insulin degludec/insulin aspart. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs decrease blood glucose.insulin detemirMonitor Closely (1)isocarboxazid increases effects of insulin detemir by unknown mechanism. Use Caution/Monitor.insulin glargineMonitor Closely (1)isocarboxazid increases effects of insulin glargine by unknown mechanism. Use Caution/Monitor.insulin glulisineMonitor Closely (1)isocarboxazid increases effects of insulin glulisine by unknown mechanism. Use Caution/Monitor.insulin inhaledMonitor Closely (1)isocarboxazid, insulin inhaled. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs decrease blood glucose.insulin lisproMonitor Closely (1)isocarboxazid increases effects of insulin lispro by unknown mechanism. Use Caution/Monitor.insulin NPHMonitor Closely (1)isocarboxazid increases effects of insulin NPH by unknown mechanism. Use Caution/Monitor.insulin regular humanMonitor Closely (1)isocarboxazid increases effects of insulin regular human by unknown mechanism. Use Caution/Monitor.iobenguane I 131Serious - Use Alternative (1)isocarboxazid will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.isomethepteneContraindicated (1)isocarboxazid, isometheptene. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Hypertension, V tach.isoniazidSerious - Use Alternative (1)isocarboxazid and isoniazid both increase serotonin levels. Avoid or Use Alternate Drug.isoproterenolContraindicated (1)isocarboxazid increases effects of isoproterenol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.ketamineSerious - Use Alternative (1)isocarboxazid increases levels of ketamine by pharmacodynamic synergism. Avoid or Use Alternate Drug.L-tryptophanSerious - Use Alternative (1)isocarboxazid and L-tryptophan both increase serotonin levels. Avoid or Use Alternate Drug.lasmiditanMonitor Closely (2)lasmiditan, isocarboxazid. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. isocarboxazid increases effects of lasmiditan by serotonin levels. Use Caution/Monitor. Coadministration may increase risk of serotonin syndrome.lemborexantMonitor Closely (1)lemborexant, isocarboxazid. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.levalbuterolSerious - Use Alternative (1)isocarboxazid increases effects of levalbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.levocetirizineSerious - Use Alternative (1)isocarboxazid increases effects of levocetirizine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .levodopaContraindicated (1)isocarboxazid, levodopa. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.levodopa inhaledContraindicated (1)levodopa inhaled increases effects of isocarboxazid by dopaminergic effects. Contraindicated. Levodopa may enhance risk for acute hypertensive episode if coadministered with nonselective MAOIs. Discontinue use of any nonselective MAO inhibitors at least 2 weeks before initiating levodopa inhaled.levomilnacipranContraindicated (1)isocarboxazid and levomilnacipran both increase serotonin levels. Contraindicated. Do not use MAOIs intended to treat psychiatric disorders with levomilnacipran or within 7 days of stopping levomilnacipran due to an increased risk of serotonin syndromelevorphanolSerious - Use Alternative (1)isocarboxazid increases toxicity of levorphanol by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.linezolidSerious - Use Alternative (1)isocarboxazid and linezolid both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.lisdexamfetamineContraindicated (1)isocarboxazid, lisdexamfetamine. Either increases effects of the other by serotonin levels. Contraindicated. Do not use amphetamines during and within 14 days of discontinuation of monoamine oxidase inhibitors. .lithiumMonitor Closely (1)lithium, isocarboxazid. Mechanism: unknown. Use Caution/Monitor. Risk of malignant hyperpyrexia. Interactions esp. expected w/non selective MAOIs.Serious - Use Alternative (1)isocarboxazid and lithium both increase serotonin levels. Avoid or Use Alternate Drug.lofepramineContraindicated (1)isocarboxazid and lofepramine both increase serotonin levels. Contraindicated.loratadineSerious - Use Alternative (1)isocarboxazid increases effects of loratadine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .lorcaserinSerious - Use Alternative (1)isocarboxazid and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.lsdSerious - Use Alternative (1)isocarboxazid and lsd both increase serotonin levels. Avoid or Use Alternate Drug.lurasidoneMonitor Closely (2)lurasidone, isocarboxazid. Either increases toxicity of the other by sedation. Use Caution/Monitor. Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity. lurasidone increases effects of isocarboxazid by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of hypotension with concurrent use. Monitor blood pressure and adjust dose of antihypertensive agent as needed.maprotilineContraindicated (1)isocarboxazid and maprotiline both increase serotonin levels. Contraindicated.maravirocMonitor Closely (1)maraviroc, isocarboxazid. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of orthostatic hypotension.meperidineContraindicated (2)isocarboxazid and meperidine both increase serotonin levels. Contraindicated. isocarboxazid increases toxicity of meperidine by unknown mechanism. Contraindicated.metaproterenolSerious - Use Alternative (1)isocarboxazid increases effects of metaproterenol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.metforminMonitor Closely (1)isocarboxazid will increase the level or effect of metformin by unspecified interaction mechanism. Use Caution/Monitor.methadoneSerious - Use Alternative (1)isocarboxazid increases toxicity of methadone by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.methamphetamineContraindicated (1)isocarboxazid increases effects of methamphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.methohexitalSerious - Use Alternative (1)isocarboxazid, methohexital. Other (see comment). Contraindicated. Comment: CNS depressants such as barbiturates should not be used in combination with isocarboxazid.methyclothiazideSerious - Use Alternative (1)isocarboxazid, methyclothiazide. Other (see comment). Contraindicated. Comment: Additive hypotensive effects may be seen when MAOI's are combined with antihypertensives.methylene blueSerious - Use Alternative (1)methylene blue and isocarboxazid both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first.methylenedioxymethamphetamineContraindicated (1)isocarboxazid increases effects of methylenedioxymethamphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.methylphenidateContraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI.methylphenidate transdermalContraindicated (1)methylphenidate transdermal and isocarboxazid both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Coadministration of MAOIs and CNS stimulants can cause hypertensive crisis.metoclopramide intranasalSerious - Use Alternative (1)metoclopramide intranasal increases toxicity of isocarboxazid by Other (see comment). Avoid or Use Alternate Drug. Comment: Metoclopramide may enhance the hypertensive effect of monoamine oxidase inhibitors.metolazoneSerious - Use Alternative (1)isocarboxazid, metolazone. Other (see comment). Contraindicated. Comment: Additive hypotensive effects may be seen when MAOI's are combined with antihypertensives.metrizamideMonitor Closely (1)isocarboxazid, metrizamide. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Risk of seizure. D/C MAO inhibitor 24h before admin. of metrizamide.midodrineContraindicated (1)isocarboxazid increases effects of midodrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.milnacipranContraindicated (1)isocarboxazid and milnacipran both increase serotonin levels. Contraindicated.mirtazapineSerious - Use Alternative (1)isocarboxazid and mirtazapine both increase serotonin levels. Avoid or Use Alternate Drug.modafinilContraindicated (1)isocarboxazid increases effects of modafinil by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.morphineSerious - Use Alternative (2)isocarboxazid and morphine both increase serotonin levels. Avoid or Use Alternate Drug. isocarboxazid increases toxicity of morphine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.nalbuphineSerious - Use Alternative (1)isocarboxazid increases toxicity of nalbuphine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.naratriptanSerious - Use Alternative (2)naratriptan and isocarboxazid both increase serotonin levels. Avoid or Use Alternate Drug. isocarboxazid increases levels of naratriptan by decreasing metabolism. Contraindicated.nefazodoneContraindicated (1)isocarboxazid and nefazodone both increase serotonin levels. Contraindicated.netupitant/palonosetronSerious - Use Alternative (1)netupitant/palonosetron, isocarboxazid. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.norepinephrineContraindicated (1)isocarboxazid increases effects of norepinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.nortriptylineContraindicated (1)isocarboxazid and nortriptyline both increase serotonin levels. Contraindicated.oliceridineMonitor Closely (1)isocarboxazid, oliceridine. Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely.olodaterol inhaledMonitor Closely (1)isocarboxazid and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. MAO inhibitors prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmiasondansetronSerious - Use Alternative (1)ondansetron, isocarboxazid. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.opicaponeContraindicated (1)opicapone, isocarboxazid. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Both nonselective MAO inhibitors and opicapone inhibit catecholamine metabolism, leading to increased levels of catecholamines. Potential for dangerously high HR or BP.opium tinctureMonitor Closely (1)opium tincture, isocarboxazid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.Serious - Use Alternative (1)isocarboxazid increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.oxycodoneSerious - Use Alternative (1)isocarboxazid increases toxicity of oxycodone by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.oxymetazoline intranasalSerious - Use Alternative (1)isocarboxazid increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. MAOIs