AdultPediatricDosage Forms & Strengths solution for nebulization 11.25mg/0.5mL (2.25% as 1.125% dextro-epinephrine and 1.125% levo-epinephrine) Bronchial Asthma Indicated for temporary relieve of symptoms associated with bronchial asthma (eg, shortness of breath, chest tightening, wheezing) S2: 0.5 mL of 2.25% solution diluted in 3 mL NS via jet nebulizer q3-4hr PRN Asthmanefrin: 1-3 inhalations of 0.5 mL of 2.25% solution via EZ Breathe AtomizerDosage Forms & Strengths solution for nebulization 11.25mg/0.5mL (2.25% as 1.125% dextro-epinephrine and 1.125% levo-epinephrine) Bronchial Asthma Indicated for temporary relieve of symptoms associated with bronchial asthma (eg, shortness of breath, chest tightening, wheezing) Asthmanefrin <4 years: Safety and efficacy not established ≥4 years: 1-3 inhalations of 0.5 mL of 2.25% solution via EZ Breathe Atomizer S2 <4 years old: 0.05 mL/kg via jet nebulizer (diluted to 3 mL with NS) over 15 minutes; no more than q12hr; not to exceed 0.5 mL/dose ≥4 years old: 0.5 mL of 2.25% solution via jet nebulizer (diluted to 3 mL with NS) over 15 minutes q3-4 hr PRN Use low end of dosing range for younger infants Should observe rapid response, can be repeated q2hr in older children but monitor HR with repeated dosing Croup <4 years: 0.05 mL/kg of 2.25% solution (S2) via jet nebulizer (diluted to 3 mL with NS) over 15 minutes q3-4 hr PRN; not to exceed 0.5 mL/dose ≥4 years old: 0.5 mL of 2.25% solution (S2) via jet nebulizer (diluted to 3 mL with NS) over 15 minutes q3-4 hr PRNInteraction CheckerEnter a drug name and epinephrine racemicNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (10)arsenic trioxideepinephrine racemic and arsenic trioxide both increase QTc interval. Contraindicated.disopyramideepinephrine racemic and disopyramide both increase QTc interval. Contraindicated.ibutilideepinephrine racemic and ibutilide both increase QTc interval. Contraindicated.indapamideepinephrine racemic and indapamide both increase QTc interval. Contraindicated.iobenguane I 123epinephrine racemic decreases levels of iobenguane I 123 by receptor binding competition. Contraindicated. If clinically appropriate, discontinue drugs that compete for NE receptor sites for at least 5 half-lives; may cause false-negative imaging results.pentamidineepinephrine racemic and pentamidine both increase QTc interval. Contraindicated.pimozideepinephrine racemic and pimozide both increase QTc interval. Contraindicated.procainamideepinephrine racemic and procainamide both increase QTc interval. Contraindicated.quinidineepinephrine racemic and quinidine both increase QTc interval. Contraindicated.sotalolepinephrine racemic and sotalol both increase QTc interval. Contraindicated.Serious - Use Alternative (57)amiodaroneepinephrine racemic and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amitriptylineepinephrine racemic and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amoxapineepinephrine racemic and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.artemether/lumefantrineepinephrine racemic and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazineepinephrine racemic and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinepinephrine racemic and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineepinephrine racemic and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.clomipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.desfluranedesflurane increases levels of epinephrine racemic by decreasing metabolism. Contraindicated.desipramineepinephrine racemic and desipramine both increase QTc interval. Avoid or Use Alternate Drug.desipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilideepinephrine racemic and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dosulepinepinephrine racemic and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.doxepinepinephrine racemic and doxepin both increase QTc interval. Avoid or Use Alternate Drug.doxepin, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dronedaroneepinephrine racemic and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolepinephrine racemic and droperidol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseepinephrine racemic and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateepinephrine racemic and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateepinephrine racemic and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateepinephrine racemic and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.etomidateetomidate increases levels of epinephrine racemic by decreasing metabolism. Contraindicated.fluconazoleepinephrine racemic and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluphenazineepinephrine racemic and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.formoterolepinephrine racemic and formoterol both increase QTc interval. Avoid or Use Alternate Drug.haloperidolepinephrine racemic and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.imipramineepinephrine racemic and imipramine both increase QTc interval. Avoid or Use Alternate Drug.imipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.isocarboxazidisocarboxazid increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.ketamineketamine increases levels of epinephrine racemic by unknown mechanism. Avoid or Use Alternate Drug.ketoconazoleepinephrine racemic and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levoketoconazoleepinephrine racemic and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranlevomilnacipran increases levels of epinephrine racemic by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of paroxysmal HTN, arrhythmia.linezolidlinezolid increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lofepramineepinephrine racemic and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.lofepramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lumefantrineepinephrine racemic and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.maprotilineepinephrine racemic and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.maprotiline, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.milnacipranmilnacipran increases levels of epinephrine racemic by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of paroxysmal HTN, arrhythmia.moxifloxacinepinephrine racemic and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nadololnadolol increases effects of epinephrine racemic by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).nortriptylineepinephrine racemic and nortriptyline both increase QTc interval. Avoid or Use Alternate Drug.nortriptyline, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.octreotideepinephrine racemic and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)epinephrine racemic and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.perphenazineepinephrine racemic and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.phenelzinephenelzine increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.pindololpindolol increases effects of epinephrine racemic by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).procarbazineprocarbazine increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.prochlorperazineepinephrine racemic and prochlorperazine both increase QTc interval. Avoid or Use Alternate Drug.promazineepinephrine racemic and promazine both increase QTc interval. Avoid or Use Alternate Drug.promethazineepinephrine racemic and promethazine both increase QTc interval. Avoid or Use Alternate Drug.propofolpropofol increases levels of epinephrine racemic by unknown mechanism. Avoid or Use Alternate Drug.propranololpropranolol increases effects of epinephrine racemic by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).protriptylineepinephrine racemic and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.protriptyline, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.sevofluranesevoflurane increases levels of epinephrine racemic by unknown mechanism. Avoid or Use Alternate Drug.thioridazineepinephrine racemic and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.timololtimolol increases effects of epinephrine racemic by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypertension and bradycardia. Consider selective beta 1 blocker (e.g., metoprolol).tranylcyprominetranylcypromine increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.trazodoneepinephrine racemic and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trifluoperazineepinephrine racemic and trifluoperazine both increase QTc interval. Avoid or Use Alternate Drug.trimipramineepinephrine racemic and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.trimipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ziprasidoneepinephrine racemic and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (251)acebutololacebutolol increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acebutolol decreases effects of epinephrine racemic by pharmacodynamic antagonism. Use Caution/Monitor.aceclofenacaceclofenac increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinacemetacin increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterolalbuterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.albuterol and epinephrine racemic both decrease sedation. Use Caution/Monitor.albuterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilalfentanil increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamalprazolam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amilorideamiloride increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amitriptylineamitriptyline increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor.amobarbitalamobarbital increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineamoxapine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor.arformoterolarformoterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.arformoterol and epinephrine racemic both decrease sedation. Use Caution/Monitor.arformoterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.aripiprazolearipiprazole increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilepinephrine racemic and armodafinil both decrease sedation. Use Caution/Monitor.aspirinaspirin increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalaspirin rectal increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololatenolol increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenolol decreases effects of epinephrine racemic by pharmacodynamic antagonism. Use Caution/Monitor.azelastineazelastine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.azithromycinepinephrine racemic and azithromycin both increase QTc interval. Use Caution/Monitor.belladonna and opiumbelladonna and opium increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazideepinephrine racemic and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.benperidolbenperidol increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetamineepinephrine racemic and benzphetamine both decrease sedation. Use Caution/Monitor.epinephrine racemic and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.betaxololbetaxolol increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.betaxolol decreases effects of epinephrine racemic by pharmacodynamic antagonism. Use Caution/Monitor.bisoprololbisoprolol increases and epinephrine racemic decreases serum potassium. Effect of interaction