trazodone may require dose titration of antidepressant to desired effect (eg, using the lowest feasible initial or maintenance dose). Monitor for antidepressant response.dasatinibMonitor Closely (1)imipramine and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)dasatinib will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.debrisoquineMonitor Closely (1)imipramine decreases effects of debrisoquine by Other (see comment). Use Caution/Monitor. Comment: Inhibition of uptake by adrenergic neurons.deferasiroxMinor (1)deferasirox will decrease the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.degarelixMonitor Closely (1)degarelix and imipramine both increase QTc interval. Use Caution/Monitor.desfluraneMonitor Closely (2)desflurane and imipramine both increase QTc interval. Use Caution/Monitor. desflurane and imipramine both increase sedation. Use Caution/Monitor.Minor (1)desflurane, imipramine. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.desipramineMonitor Closely (2)desipramine and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. desipramine and imipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and imipramine both increase QTc interval. Avoid or Use Alternate Drug. desipramine and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.desvenlafaxineMonitor Closely (1)desvenlafaxine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgSerious - Use Alternative (1)imipramine and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.deutetrabenazineMonitor Closely (2)imipramine and deutetrabenazine both increase sedation. Use Caution/Monitor. deutetrabenazine and imipramine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexamethasoneMinor (1)dexamethasone will decrease the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and imipramine both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (2)imipramine and dexfenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely. imipramine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexmedetomidineMonitor Closely (1)dexmedetomidine and imipramine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)imipramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of imipramine by decreasing metabolism. Minor/Significance Unknown.dextroamphetamineMonitor Closely (3)imipramine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor. imipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely. imipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextroamphetamine transdermalMonitor Closely (1)imipramine will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Modify Therapy/Monitor Closely. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Monitor frequently and adjust or use an alternant based on clinical response.dextromethorphanSerious - Use Alternative (1)imipramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.dextromoramideMonitor Closely (1)dextromoramide and imipramine both increase sedation. Use Caution/Monitor.DHEA, herbalMinor (1)DHEA, herbal will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.diamorphineMonitor Closely (1)diamorphine and imipramine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and imipramine both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, imipramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.dicyclomineMonitor Closely (1)dicyclomine and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.diethylpropionMonitor Closely (1)imipramine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.difelikefalinMonitor Closely (1)difelikefalin and imipramine both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl and imipramine both increase sedation. Use Caution/Monitor.dihydroergotamineMonitor Closely (1)imipramine and dihydroergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.dihydroergotamine intranasalMonitor Closely (1)imipramine and dihydroergotamine intranasal both increase serotonin levels. Modify Therapy/Monitor Closely.diltiazemMonitor Closely (1)diltiazem will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and imipramine both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (3)diphenhydramine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. diphenhydramine and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. diphenhydramine and imipramine both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl and imipramine both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone and imipramine both increase sedation. Use Caution/Monitor.disopyramideContraindicated (1)imipramine and disopyramide both increase QTc interval. Contraindicated.dobutamineMonitor Closely (1)imipramine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilideSerious - Use Alternative (1)imipramine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetronMonitor Closely (1)imipramine and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)dolasetron, imipramine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.donepezilMonitor Closely (2)donepezil and imipramine both increase QTc interval. Use Caution/Monitor. donepezil increases and imipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)imipramine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexamineMonitor Closely (1)imipramine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.doxepinMonitor Closely (2)doxepin and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin and imipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and imipramine both increase QTc interval. Avoid or Use Alternate Drug. doxepin and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.doxylamineMonitor Closely (1)doxylamine and imipramine both increase sedation. Use Caution/Monitor.dronedaroneContraindicated (2)dronedarone will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. dronedarone will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Increased potential risk of torsade's de pointes-type ventricular tachycardia.Serious - Use Alternative (1)imipramine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolMonitor Closely (1)droperidol and imipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)imipramine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineMonitor Closely (1)duloxetine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)duloxetine and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.echothiophate iodideMonitor Closely (1)echothiophate iodide increases and imipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.efavirenzMonitor Closely (2)efavirenz will increase the level or effect of imipramine by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. efavirenz and imipramine both increase QTc interval. Use Caution/Monitor.Minor (1)efavirenz will decrease the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.elagolixMonitor Closely (1)elagolix will increase the level or effect of imipramine by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak CYP2C19 inhibitor. Caution with sensitive CYP2C19 substrates.eletriptanMonitor Closely (1)eletriptan and imipramine both increase serotonin levels. Modify Therapy/Monitor Closely.eliglustatContraindicated (1)imipramine increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given concomitantly with strong or moderate CYP3A inhibitors.Monitor Closely (2)eliglustat increases levels of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect. eliglustat and imipramine both increase QTc interval. Use Caution/Monitor.elvitegravir/cobicistat/emtricitabine/tenofovir DFMonitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.encorafenibSerious - Use Alternative (1)encorafenib and imipramine both increase QTc interval. Avoid or Use Alternate Drug.entrectinibMonitor Closely (1)entrectinib and imipramine both increase QTc interval. Use Caution/Monitor.ephedrineMonitor Closely (2)imipramine increases effects of ephedrine by unknown mechanism. Use Caution/Monitor. imipramine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineMonitor Closely (2)imipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. imipramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and imipramine both increase QTc interval. Avoid or Use Alternate Drug. imipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine inhaledMonitor Closely (1)imipramine and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system.epinephrine racemicMonitor Closely (2)imipramine increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor. imipramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and imipramine both increase QTc interval. Avoid or Use Alternate Drug. imipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ergotamineMonitor Closely (1)imipramine and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.eribulinMonitor Closely (1)eribulin and imipramine both increase QTc interval. Use Caution/Monitor.erythromycin baseMonitor Closely (1)erythromycin base will increase the level or effect of imipramine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.Serious - Use Alternative (2)imipramine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug. erythromycin base will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.erythromycin ethylsuccinateMonitor Closely (1)erythromycin ethylsuccinate will increase the level or effect of imipramine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.Serious - Use Alternative (2)imipramine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug. erythromycin ethylsuccinate will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.erythromycin lactobionateMonitor Closely (1)erythromycin lactobionate will increase the level or effect of imipramine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.Serious - Use Alternative (2)imipramine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug. erythromycin lactobionate will increase the level or effect of imipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.erythromycin stearateMonitor Closely (1)erythromycin stearate will increase the level or effect of imipramine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.Serious - Use Alternative (2)imipramine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug. erythromycin stearate will increase the level or effect of imipramine by affecting hepatic/intestinal