caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)lorazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)lorazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and lorazepam both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and lorazepam both increase sedation. Use Caution/Monitor.atracuriumMinor (1)lorazepam decreases effects of atracurium by pharmacodynamic antagonism. Minor/Significance Unknown.avapritinibMonitor Closely (1)avapritinib and lorazepam both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and lorazepam both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)lorazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)lorazepam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)lorazepam and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and lorazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)lorazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.biotinMinor (1)lorazepam decreases levels of biotin by unspecified interaction mechanism. Minor/Significance Unknown. Biotin supplementation may be necessary.brexanoloneMonitor Closely (1)brexanolone, lorazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and lorazepam both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and lorazepam both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of lorazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and lorazepam both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and lorazepam both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)lorazepam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)lorazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)lorazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.Serious - Use Alternative (1)buprenorphine subdermal implant and lorazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and lorazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionMonitor Closely (1)lorazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.Serious - Use Alternative (1)buprenorphine, long-acting injection and lorazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)butabarbital and lorazepam both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and lorazepam both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)lorazepam and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)lorazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)lorazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.cannabidiolMonitor Closely (1)cannabidiol will increase the level or effect of lorazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit UGT2B7 activity. Consider reducing the dose when concomitantly using UGT2B7 substrates.carbinoxamineMonitor Closely (1)carbinoxamine and lorazepam both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)lorazepam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, lorazepam. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateMonitor Closely (1)lorazepam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and lorazepam both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and lorazepam both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)lorazepam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)lorazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and lorazepam both increase sedation. Use Caution/Monitor.cisatracuriumMinor (1)lorazepam decreases effects of cisatracurium by pharmacodynamic antagonism. Minor/Significance Unknown.clemastineMonitor Closely (1)clemastine and lorazepam both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)lorazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)lorazepam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and lorazepam both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateMonitor Closely (1)clorazepate and lorazepam both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (2)lorazepam, clozapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Possible risk of cardiorespiratory collapse. lorazepam and clozapine both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)lorazepam and codeine both increase sedation. Use Caution/Monitor.cyanocobalaminMinor (1)lorazepam decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.cyclizineMonitor Closely (1)cyclizine and lorazepam both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)lorazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and lorazepam both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)lorazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)lorazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluraneMonitor Closely (1)desflurane and lorazepam both increase sedation. Use Caution/Monitor.desipramineMonitor Closely (1)lorazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)lorazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and lorazepam both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)lorazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)lorazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)lorazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor/Significance Unknown.dextroamphetamineMonitor Closely (1)lorazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)lorazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)lorazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and lorazepam both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.dichlorphenamideMonitor Closely (1)dichlorphenamide, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diethylpropionMonitor Closely (1)lorazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and lorazepam both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)lorazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and lorazepam both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and lorazepam both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)lorazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)lorazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineMonitor Closely (1)lorazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)lorazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)lorazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)lorazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)lorazepam and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)lorazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)lorazepam and droperidol both increase sedation. Use Caution/Monitor.ephedrineMonitor Closely (1)lorazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)lorazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)lorazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)esketamine intranasal, lorazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.esomeprazoleMinor (1)esomeprazole increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.estazolamMonitor Closely (1)estazolam and lorazepam both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (1)lorazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and lorazepam both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)lorazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fenfluramineMonitor Closely (1)lorazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fleroxacinMinor (1)fleroxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.flibanserinMonitor Closely (1)lorazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineMonitor Closely (1)lorazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam and lorazepam both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)lorazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentinMonitor Closely (1)gabapentin, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)lorazepam and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinMinor (1)gemifloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.green teaMinor (1)green tea decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.haloperidolMonitor Closely (1)lorazepam and haloperidol both increase sedation. Use Caution/Monitor.hyaluronidaseMonitor Closely (1)hyaluronidase, lorazepam. Other (see comment). Use Caution/Monitor. Comment: Drug combination has been found to be incompatible.hydrocodoneSerious - Use Alternative (1)hydrocodone, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)lorazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and lorazepam both increase sedation. Use Caution/Monitor.iloperidoneMonitor Closely (1)lorazepam and iloperidone both increase sedation. Use Caution/Monitor.imipramineMonitor Closely (1)lorazepam and imipramine both increase sedation. Use Caution/Monitor.isoproterenolMonitor Closely (1)lorazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineMonitor Closely (1)ketamine and lorazepam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicMonitor Closely (1)lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanMonitor Closely (1)lasmiditan, lorazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantMonitor Closely (1)lemborexant, lorazepam. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.levalbuterolMonitor Closely (1)lorazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levocarnitineMinor (1)lorazepam decreases levels of levocarnitine by unspecified interaction mechanism. Minor/Significance Unknown.levofloxacinMinor (1)levofloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.levorphanolMonitor Closely (1)lorazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)lorazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineMonitor Closely (1)lorazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineMonitor Closely (1)lorazepam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamMonitor Closely (1)loprazolam and lorazepam both increase sedation. Use Caution/Monitor.lormetazepamMonitor Closely (1)lorazepam and lormetazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (2)lorazepam, loxapine. Mechanism: unknown. Use Caution/Monitor. Risk of resp. depression, hypotension. lorazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (2)lorazepam, loxapine inhaled. Mechanism: unknown. Use Caution/Monitor. Risk of resp. depression, hypotension. lorazepam and loxapine inhaled both increase sedation. Use