the cardiovascular system may be potentiated.desipramine and umeclidinium bromide/vilanterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiatedvandetanibdesipramine, vandetanib. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.vemurafenibvemurafenib and desipramine both increase QTc interval. Avoid or Use Alternate Drug. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended.venlafaxinevenlafaxine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaleddesipramine and vilanterol/fluticasone furoate inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiateddesipramine increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vilazodonedesipramine, vilazodone. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. .vortioxetinedesipramine, vortioxetine. Either increases effects of the other by serotonin levels. Avoid or Use Alternate Drug.xylometazolinedesipramine, xylometazoline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.yohimbeyohimbe, desipramine. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.yohimbinedesipramine, yohimbine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ziprasidonedesipramine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (354)5-HTPdesipramine and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.abirateroneabiraterone increases levels of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.abobotulinumtoxinAabobotulinumtoxinA increases effects of desipramine by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .aclidiniumaclidinium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.acrivastineacrivastine and desipramine both increase sedation. Use Caution/Monitor.albuteroldesipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and desipramine both increase QTc interval. Use Caution/Monitor.alfentanilalfentanil and desipramine both increase sedation. Use Caution/Monitor.alfuzosindesipramine and alfuzosin both increase QTc interval. Use Caution/Monitor.alfuzosin and desipramine both increase QTc interval. Use Caution/Monitor.almotriptanalmotriptan and desipramine both increase serotonin levels. Modify Therapy/Monitor Closely.alprazolamalprazolam and desipramine both increase sedation. Use Caution/Monitor.amifampridinedesipramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.amiodaroneamiodarone will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.amisulpridedesipramine and amisulpride both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.amisulpride and desipramine both increase sedation. Use Caution/Monitor.amitriptylineamitriptyline and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.amitriptyline and desipramine both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and desipramine both increase sedation. Use Caution/Monitor.amoxapineamoxapine and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and desipramine both increase sedation. Use Caution/Monitor.anagrelideanagrelide and desipramine both increase QTc interval. Use Caution/Monitor.apomorphinedesipramine and apomorphine both increase sedation. Use Caution/Monitor.apomorphine and desipramine both increase QTc interval. Use Caution/Monitor.arformoteroldesipramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and desipramine both increase QTc interval. Use Caution/Monitor.aripiprazolearipiprazole and desipramine both increase sedation. Use Caution/Monitor.aripiprazole and desipramine both increase QTc interval. Use Caution/Monitor.armodafinildesipramine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineasenapine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapine and desipramine both increase QTc interval. Use Caution/Monitor.asenapine and desipramine both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and desipramine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and desipramine both increase sedation. Use Caution/Monitor.atazanaviratazanavir increases levels of desipramine by unspecified interaction mechanism. Use Caution/Monitor.atomoxetineatomoxetine and desipramine both increase QTc interval. Use Caution/Monitor.atropine IV/IMatropine IV/IM and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.avapritinibavapritinib and desipramine both increase sedation. Use Caution/Monitor.azelastineazelastine and desipramine both increase sedation. Use Caution/Monitor.azithromycindesipramine and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenbaclofen and desipramine both increase sedation. Use Caution/Monitor.bedaquilinedesipramine and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna and opiumbelladonna and opium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opium and desipramine both increase sedation. Use Caution/Monitor.benperidolbenperidol and desipramine both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, desipramine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.benzphetaminedesipramine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexpiprazoledesipramine will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor. brexpiprazole and desipramine both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and desipramine both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and desipramine both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and desipramine both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and desipramine both increase sedation. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and desipramine both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantdesipramine, buprenorphine subdermal implant. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine, long-acting injectiondesipramine, buprenorphine, long-acting injection. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.bupropionbupropion will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.desipramine increases toxicity of bupropion by unspecified interaction mechanism. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible.butabarbitalbutabarbital and desipramine both increase sedation. Use Caution/Monitor.butalbitalbutalbital and desipramine both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and desipramine both increase sedation. Use Caution/Monitor.caffeinedesipramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and desipramine both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and desipramine both increase sedation. Use Caution/Monitor.celecoxibcelecoxib will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.cenobamatecenobamate, desipramine. Either increases effects of the other by sedation. Use Caution/Monitor.ceritinibceritinib and desipramine both increase QTc interval. Use Caution/Monitor.chloral hydratechloral hydrate and desipramine both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and desipramine both increase sedation. Use Caution/Monitor.chloroquinechloroquine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.chloroquine increases toxicity of desipramine by QTc interval. Use Caution/Monitor.chlorpheniraminechlorpheniramine and desipramine both increase sedation. Use Caution/Monitor.chlorpromazinechlorpromazine and desipramine both increase sedation. Use Caution/Monitor.chlorzoxazonechlorzoxazone and desipramine both increase sedation. Use Caution/Monitor.cimetidinecimetidine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.cinnarizinecinnarizine and desipramine both increase sedation. Use Caution/Monitor.cisapridedesipramine and cisapride both increase QTc interval. Use Caution/Monitor.clemastineclemastine and desipramine both increase sedation. Use Caution/Monitor.clobazamclobazam will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. desipramine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineclomipramine and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.clomipramine and desipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and desipramine both increase sedation. Use Caution/Monitor.clorazepateclorazepate and desipramine both increase sedation. Use Caution/Monitor.clozapineclozapine and desipramine both increase sedation. Use Caution/Monitor.clozapine and desipramine both increase QTc interval. Use Caution/Monitor.cobicistatcobicistat will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Carefully titrate antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant responsecobicistat will increase the level or effect of desipramine by Other (see comment). Use Caution/Monitor. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. cocaine topicaldesipramine and cocaine topical both increase serotonin levels. Modify Therapy/Monitor Closely.codeinecodeine and desipramine both increase sedation. Use Caution/Monitor.desipramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.crizotinibcrizotinib and desipramine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.cyclizinecyclizine and desipramine both increase sedation. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and desipramine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and desipramine both increase sedation. Use Caution/Monitor.dantrolenedantrolene and desipramine both increase sedation. Use Caution/Monitor.daridorexantdesipramine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darifenacindarifenacin will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.dasatinibdesipramine and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.debrisoquinedesipramine decreases effects of debrisoquine by Other (see comment). Use Caution/Monitor. Comment: Inhibition of uptake by adrenergic neurons.degarelixdegarelix and desipramine both increase QTc interval. Use Caution/Monitor.desfluranedesflurane and desipramine both increase sedation. Use Caution/Monitor.desflurane and desipramine both increase QTc interval. Use Caution/Monitor.desvenlafaxinedesvenlafaxine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgdeutetrabenazinedesipramine and deutetrabenazine both increase sedation. Use Caution/Monitor.deutetrabenazine and desipramine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniraminedexchlorpheniramine and desipramine both increase sedation. Use Caution/Monitor.dexfenfluraminedesipramine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.desipramine and dexfenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.dexmedetomidinedexmedetomidine and desipramine both increase sedation. Use Caution/Monitor.dexmethylphenidatedesipramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminedesipramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.desipramine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.desipramine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.dextroamphetamine transdermaldesipramine will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Modify Therapy/Monitor Closely. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Monitor frequently and adjust or use an alternant based on clinical response.dextromoramidedextromoramide and desipramine both increase sedation. Use Caution/Monitor.diamorphinediamorphine and desipramine both increase sedation. Use Caution/Monitor.diazepamdiazepam and desipramine both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, desipramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropiondesipramine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and desipramine both increase sedation. Use Caution/Monitor.difenoxin hcldifenoxin hcl and desipramine both increase sedation. Use Caution/Monitor.dihydroergotaminedesipramine and dihydroergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.dihydroergotamine intranasaldesipramine and dihydroergotamine intranasal both increase serotonin levels. Modify Therapy/Monitor Closely.dimenhydrinatedimenhydrinate and desipramine both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.diphenhydramine and desipramine both increase sedation. Use Caution/Monitor.diphenoxylate hcldiphenoxylate hcl and desipramine both increase sedation. Use Caution/Monitor.dipipanonedipipanone and desipramine both