AdultPediatricDosage Forms & Strengths capsule: Schedule IV 500mg syrup: Schedule IV 500mg/5mL Insomnia Indicated for use as hypnotic for simple insomnia; rarely used for this indication 500 mg to 1 g PO 15-30 minutes before bedtime; for short-term use only (ie, up to 2 weeks); not to exceed 2 g/24hr Sedative/Anxiety 250 mg PO PC q8hr; not to exceed 2 g/day Renal Impairment Contraindicated in moderate-severe renal impairment Hepatic Impairment Contraindicated in moderate-severe hepatic impairment Administration Upon discontinuation withdraw gradually over 2 weeks if patient maintained on high doses for prolong periods of time; abrupt discontinuation may result in deliriumDosage Forms & Strengths capsule: Schedule IV 500mg syrup: Schedule IV 500mg/5mL Sedation for Procedures (Off-label) 50-75 mg/kg PO 30-60 min before procedure; may repeat in 30 min if necessary Not to exceed 120 mg/kg or 1 g/dose in infants or 2 g/dose in children Sedation/Anxiety (Off-label) May be used prior to procedure or EEG evaluation 25-50 mg/kg/day PO divided q6-8hr; not to exceed 500 mg/dose Interaction CheckerEnter a drug name and chloral hydrateNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (2)calcium/magnesium/potassium/sodium oxybateschloral hydrate, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.sodium oxybatechloral hydrate, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.Serious - Use Alternative (13)benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, chloral hydrate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.fentanylfentanyl, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalfentanyl intranasal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.hydrocodonehydrocodone, chloral hydrate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.lemborexantlemborexant, chloral hydrate. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.mefloquinemefloquine increases toxicity of chloral hydrate by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.metoclopramide intranasalchloral hydrate, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olopatadine intranasalchloral hydrate and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. selinexorselinexor, chloral hydrate. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sufentanil SLsufentanil SL, chloral hydrate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.valerianvalerian and chloral hydrate both increase sedation. Avoid or Use Alternate Drug.Monitor Closely (190)albuterolchloral hydrate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilchloral hydrate and alfentanil both increase sedation. Use Caution/Monitor.alprazolamalprazolam and chloral hydrate both increase sedation. Use Caution/Monitor.amitriptylinechloral hydrate and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and chloral hydrate both increase sedation. Use Caution/Monitor.amoxapinechloral hydrate and amoxapine both increase sedation. Use Caution/Monitor.apomorphinechloral hydrate and apomorphine both increase sedation. Use Caution/Monitor.arformoterolchloral hydrate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazolechloral hydrate and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilchloral hydrate increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.azelastineazelastine and chloral hydrate both increase sedation. Use Caution/Monitor.baclofenchloral hydrate and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumchloral hydrate and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolchloral hydrate and benperidol both increase sedation. Use Caution/Monitor.benzphetaminechloral hydrate increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanolonebrexanolone, chloral hydrate. Either increases toxicity of the other by sedation. Use Caution/Monitor.brompheniraminebrompheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.buprenorphinechloral hydrate and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalchloral hydrate and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionchloral hydrate increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.butabarbitalbutabarbital and chloral hydrate both increase sedation. Use Caution/Monitor.butalbitalbutalbital and chloral hydrate both increase sedation. Use Caution/Monitor.butorphanolchloral hydrate and butorphanol both increase sedation. Use Caution/Monitor.caffeinechloral hydrate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and chloral hydrate both increase sedation. Use Caution/Monitor.carisoprodolchloral hydrate and carisoprodol both increase sedation. Use Caution/Monitor.cenobamatecenobamate, chloral hydrate. Either increases effects of the other by sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and chloral hydrate both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.chlorpromazinechloral hydrate and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazonechloral hydrate and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizinecinnarizine and chloral hydrate both increase sedation. Use Caution/Monitor.clemastineclemastine and chloral hydrate both increase sedation. Use Caution/Monitor.clobazamchloral hydrate, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipraminechloral hydrate and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and chloral hydrate both increase sedation. Use Caution/Monitor.clorazepateclorazepate and chloral hydrate both increase sedation. Use Caution/Monitor.clozapinechloral hydrate and clozapine both increase sedation. Use Caution/Monitor.codeinechloral hydrate and codeine both increase sedation. Use Caution/Monitor.cyclizinecyclizine and chloral hydrate both increase sedation. Use Caution/Monitor.cyclobenzaprinechloral hydrate and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and chloral hydrate both increase sedation. Use Caution/Monitor.dantrolenechloral hydrate and dantrolene both increase sedation. Use Caution/Monitor.daridorexantchloral hydrate and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desipraminechloral hydrate and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazinechloral hydrate and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.dexfenfluraminechloral hydrate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinechloral hydrate and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidatechloral hydrate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminechloral hydrate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramidechloral hydrate and dextromoramide both increase sedation. Use Caution/Monitor.diamorphinechloral hydrate and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiazepam and chloral hydrate both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionchloral hydrate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and chloral hydrate both increase sedation. Use Caution/Monitor.difenoxin hclchloral hydrate and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and chloral hydrate both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and chloral hydrate both increase sedation. Use Caution/Monitor.diphenoxylate hclchloral hydrate and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanonechloral hydrate and dipipanone both increase sedation. Use Caution/Monitor.dobutaminechloral hydrate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopaminechloral hydrate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexaminechloral hydrate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinchloral hydrate and dosulepin both increase sedation. Use Caution/Monitor.doxepinchloral hydrate and doxepin both increase sedation. Use Caution/Monitor.doxylaminechloral hydrate and doxylamine both increase sedation. Use Caution/Monitor.droperidolchloral hydrate and droperidol both increase sedation. Use Caution/Monitor.ephedrinechloral hydrate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrinechloral hydrate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicchloral hydrate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamestazolam and chloral hydrate both increase sedation. Use Caution/Monitor.ethanolchloral hydrate and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and chloral hydrate both increase sedation. Use Caution/Monitor.fenfluraminechloral hydrate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinchloral hydrate and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazinechloral hydrate and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and chloral hydrate both increase sedation. Use Caution/Monitor.formoterolchloral hydrate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentingabapentin, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxolonechloral hydrate and ganaxolone both increase sedation. Use Caution/Monitor.gotu kolagotu kola increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.haloperidolchloral hydrate and haloperidol both increase sedation. Use Caution/Monitor.hawthornhawthorn increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.hopshops increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.hydromorphonechloral hydrate and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and chloral hydrate both increase sedation. Use Caution/Monitor.iloperidonechloral hydrate and iloperidone both increase sedation. Use Caution/Monitor.imipraminechloral hydrate and imipramine both increase sedation. Use Caution/Monitor.isoproterenolchloral hydrate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.kavakava increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.ketamineketamine and chloral hydrate both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicchloral hydrate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, chloral hydrate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.levalbuterolchloral hydrate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanolchloral hydrate and levorphanol