increase sedation. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.antithrombin alfaantithrombin alfa and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.antithrombin IIIantithrombin III and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.apomorphinediphenhydramine and apomorphine both increase sedation. Use Caution/Monitor.arformoteroldiphenhydramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.argatrobanargatroban and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.aripiprazolediphenhydramine and aripiprazole both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.aripiprazole increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.armodafinildiphenhydramine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineasenapine and diphenhydramine both increase sedation. Use Caution/Monitor.ibuprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.asenapine transdermalasenapine transdermal and diphenhydramine both increase sedation. Use Caution/Monitor.aspirinaspirin and ibuprofen both increase anticoagulation. Use Caution/Monitor.aspirin and ibuprofen both increase serum potassium. Use Caution/Monitor.aspirin rectalaspirin rectal and ibuprofen both increase anticoagulation. Use Caution/Monitor.aspirin rectal and ibuprofen both increase serum potassium. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate and ibuprofen both increase anticoagulation. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonate and ibuprofen both increase serum potassium. Use Caution/Monitor.atenololatenolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.atomoxetinediphenhydramine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.atracuriumatracurium and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineatropine and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMatropine IV/IM and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.avapritinibavapritinib and diphenhydramine both increase sedation. Use Caution/Monitor.azelastineazelastine and diphenhydramine both increase sedation. Use Caution/Monitor.azficel-Tazficel-T, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: Patients taking NSAIDS may experience increased bruising or bleeding at biopsy and/or injection sites. Concomitant use of NSAIDs is not recommended.azilsartanibuprofen, azilsartan. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ibuprofen decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.baclofendiphenhydramine and baclofen both increase sedation. Use Caution/Monitor.belladonna alkaloidsbelladonna alkaloids and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumdiphenhydramine and belladonna and opium both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenhydramine and belladonna and opium both increase sedation. Use Caution/Monitor.bemiparinbemiparin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.benazeprilbenazepril, ibuprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.bendroflumethiazideibuprofen increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.benperidoldiphenhydramine and benperidol both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.benperidol increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benzhydrocodone/acetaminophendiphenhydramine will increase the level or effect of benzhydrocodone/acetaminophen by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Hydromorphone (<3% of the circulating parent hydrocodone [benzhydrocodone is prodrug of hydrocodone]) is mainly formed by CYP2D6 mediated O-demethylation of hydrocodone. Hydromorphone may contribute to the total analgesic effect of hydrocodone.benzhydrocodone/acetaminophen and diphenhydramine both increase sedation. Use Caution/Monitor.benzphetaminediphenhydramine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benztropinebenztropine and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. betaxololbetaxolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.bethanecholbethanechol increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.betrixabanibuprofen, betrixaban. Either increases levels of the other by anticoagulation. Use Caution/Monitor.bimatoprostbimatoprost, ibuprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).bisoprololbisoprolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.bivalirudinbivalirudin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.brexanolonebrexanolone, diphenhydramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolediphenhydramine will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor. brexpiprazole and diphenhydramine both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and diphenhydramine both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and diphenhydramine both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and diphenhydramine both increase sedation. Use Caution/Monitor.budesonideibuprofen, budesonide. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.bumetanideibuprofen increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.buprenorphinediphenhydramine and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccaldiphenhydramine and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and diphenhydramine both increase sedation. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and diphenhydramine both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and diphenhydramine both increase sedation. Use Caution/Monitor.butabarbitaldiphenhydramine and butabarbital both increase sedation. Use Caution/Monitor.butalbitaldiphenhydramine and butalbital both increase sedation. Use Caution/Monitor.butorphanoldiphenhydramine and butorphanol both increase sedation. Use Caution/Monitor.caffeinediphenhydramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.candesartancandesartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, ibuprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.captoprilcaptopril, ibuprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.carbacholcarbachol increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbamazepineibuprofen will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor plasma levels when used concomitantlycarbenoxoloneibuprofen increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and diphenhydramine both increase sedation. Use Caution/Monitor.carisoprodoldiphenhydramine and carisoprodol both increase sedation. Use Caution/Monitor.carvedilolcarvedilol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.diphenhydramine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.celecoxibcelecoxib and ibuprofen both increase anticoagulation. Use Caution/Monitor.celecoxib and ibuprofen both increase serum potassium. Use Caution/Monitor.cenobamatecenobamate, diphenhydramine. Either increases effects of the other by sedation. Use Caution/Monitor.celiprololceliprolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.cevimelinecevimeline increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydratediphenhydramine and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxidediphenhydramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.chlorothiazideibuprofen increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpheniraminechlorpheniramine and diphenhydramine both increase sedation. Use Caution/Monitor.chlorpromazinediphenhydramine and chlorpromazine both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.chlorpropamideibuprofen increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.chlorthalidoneibuprofen increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorzoxazonediphenhydramine and chlorzoxazone both increase sedation. Use Caution/Monitor.choline magnesium trisalicylateibuprofen and choline magnesium trisalicylate both increase anticoagulation. Use Caution/Monitor.ibuprofen and choline magnesium trisalicylate both increase serum potassium. Use Caution/Monitor.cinnamonibuprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.cinnarizinecinnarizine and diphenhydramine both increase sedation. Use Caution/Monitor.ciprofloxacinibuprofen, ciprofloxacin. Other (see comment). Modify Therapy/Monitor Closely. Comment: Mechanism: unknown. Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.cisatracuriumcisatracurium and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.citalopramcitalopram, ibuprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. If possible, avoid concurrent use.clemastineclemastine and diphenhydramine both increase sedation. Use Caution/Monitor.clobazamdiphenhydramine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipraminediphenhydramine will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.clomipramine, ibuprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.diphenhydramine and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenhydramine and clomipramine both increase sedation. Use Caution/Monitor.clonazepamdiphenhydramine and clonazepam both increase sedation. Use Caution/Monitor.clopidogrelclopidogrel, ibuprofen. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.clorazepatediphenhydramine and clorazepate both increase sedation. Use Caution/Monitor.clozapinediphenhydramine and clozapine both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.clozapine increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.codeinediphenhydramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.diphenhydramine and codeine both increase sedation. Use Caution/Monitor.cordycepsibuprofen and cordyceps both increase anticoagulation. Use Caution/Monitor.cortisoneibuprofen, cortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.cyclizinecyclizine and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclizine and diphenhydramine both increase sedation. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenhydramine and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyclopenthiazideibuprofen increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclosporineibuprofen, cyclosporine. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity.cyproheptadinecyproheptadine and diphenhydramine both increase sedation. Use Caution/Monitor.dabigatrandabigatran and ibuprofen both increase anticoagulation. Use Caution/Monitor. Caution is advised, both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.dalteparindalteparin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.dantrolenediphenhydramine and dantrolene both increase sedation. Use Caution/Monitor.daridorexantdiphenhydramine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darifenacindarifenacin and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.deferasiroxdeferasirox, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase GI bleeding, ulceration and irritation. Use with caution.defibrotidedefibrotide increases effects of ibuprofen by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Defibrotide may enhance effects of platelet inhibitors.deflazacortibuprofen, deflazacort. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.desfluranedesflurane and diphenhydramine both increase sedation. Use Caution/Monitor.desipraminediphenhydramine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.diphenhydramine and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazinediphenhydramine and deutetrabenazine both increase sedation. Use Caution/Monitor.dexamethasoneibuprofen, dexamethasone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.dexchlorpheniraminedexchlorpheniramine and diphenhydramine both increase sedation. Use Caution/Monitor.dexfenfluraminediphenhydramine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinediphenhydramine and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidatediphenhydramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminediphenhydramine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramidediphenhydramine and dextromoramide both increase sedation. Use Caution/Monitor.diamorphinediphenhydramine and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiphenhydramine and diazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, diphenhydramine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.dichlorphenamidedichlorphenamide, ibuprofen. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diclofenacdiclofenac and ibuprofen both increase anticoagulation. Use Caution/Monitor.diclofenac and ibuprofen both increase serum potassium. Use Caution/Monitor.dicyclominedicyclomine and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.diethylpropiondiphenhydramine increases and diethylpropion decreases sedation. Effect