signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)clonazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and clonazepam both increase sedation. Use Caution/Monitor.idelalisibSerious - Use Alternative (1)idelalisib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substratesiloperidoneMonitor Closely (2)clonazepam and iloperidone both increase sedation. Use Caution/Monitor. iloperidone increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imipramineMonitor Closely (1)clonazepam and imipramine both increase sedation. Use Caution/Monitor.indinavirMonitor Closely (1)indinavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.isoproterenolMonitor Closely (1)clonazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineMonitor Closely (1)istradefylline will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleMonitor Closely (1)itraconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.ivosidenibSerious - Use Alternative (1)ivosidenib will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.kavaMonitor Closely (1)kava and clonazepam both increase sedation. Use Caution/Monitor.ketamineMonitor Closely (1)ketamine and clonazepam both increase sedation. Use Caution/Monitor.ketoconazoleMonitor Closely (1)ketoconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.ketotifen, ophthalmicMonitor Closely (1)clonazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.larotrectinibMinor (1)larotrectinib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.lasmiditanMonitor Closely (1)lasmiditan, clonazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantMonitor Closely (1)lemborexant, clonazepam. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lenacapavirMonitor Closely (1)lenacapavir will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. letermovirMonitor Closely (1)letermovir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterolMonitor Closely (1)clonazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levocarnitineMinor (1)clonazepam decreases levels of levocarnitine by unspecified interaction mechanism. Minor/Significance Unknown.levofloxacinMinor (1)levofloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.levoketoconazoleMonitor Closely (1)levoketoconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.levonorgestrel oral/ethinylestradiol/ferrous bisglycinateMonitor Closely (1)levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will increase the level or effect of clonazepam by decreasing metabolism. Use Caution/Monitor. Ethinyl estradiol may inhibit the clearance of benzodiazepines that undergo oxidation, thereby increasing serum concentrations of concomitantly administered benzodiazepines.levorphanolMonitor Closely (1)clonazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)clonazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineMonitor Closely (1)clonazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineMonitor Closely (1)clonazepam and lofexidine both increase sedation. Use Caution/Monitor.lonafarnibSerious - Use Alternative (1)lonafarnib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.lopinavirMonitor Closely (1)lopinavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Use alternatives if available. Consider lowering benzodiazepine dose.loprazolamMonitor Closely (1)clonazepam and loprazolam both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)clonazepam and lorazepam both increase sedation. Use Caution/Monitor.lorlatinibMonitor Closely (1)lorlatinib will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.lormetazepamMonitor Closely (1)clonazepam and lormetazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)clonazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)clonazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, clonazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineMonitor Closely (1)clonazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)clonazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninMonitor Closely (1)clonazepam and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)clonazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)clonazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)clonazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)clonazepam and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)clonazepam and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)clonazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)clonazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)clonazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidate transdermalMonitor Closely (1)methylphenidate transdermal will increase the level or effect of clonazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. metoclopramide intranasalSerious - Use Alternative (1)clonazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midazolamMonitor Closely (1)clonazepam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalMonitor Closely (1)midazolam intranasal, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineMonitor Closely (1)clonazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristoneMonitor Closely (1)mifepristone will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.mirtazapineMonitor Closely (1)clonazepam and mirtazapine both increase sedation. Use Caution/Monitor.mitotaneMonitor Closely (1)mitotane decreases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilMonitor Closely (1)clonazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineMonitor Closely (1)clonazepam and morphine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)clonazepam and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinMinor (1)moxifloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.moxonidineMonitor Closely (1)clonazepam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)clonazepam and nabilone both increase sedation. Use Caution/Monitor.nafcillinMonitor Closely (1)nafcillin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nalbuphineMonitor Closely (1)clonazepam and nalbuphine both increase sedation. Use Caution/Monitor.nefazodoneMonitor Closely (1)nefazodone will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nelfinavirMonitor Closely (1)nelfinavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.norepinephrineMonitor Closely (1)clonazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineMonitor Closely (1)clonazepam and nortriptyline both increase sedation. Use Caution/Monitor.ofloxacinMinor (1)ofloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.olanzapineMonitor Closely (1)clonazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (1)oliceridine, clonazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olopatadine intranasalSerious - Use Alternative (1)clonazepam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. omeprazoleMinor (1)omeprazole increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.onabotulinumtoxinAMinor (1)clonazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Minor/Significance Unknown.opium tinctureMonitor Closely (1)clonazepam and opium tincture both increase sedation. Use Caution/Monitor.orlistatMonitor Closely (1)orlistat decreases levels of clonazepam by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of convulsions.orphenadrineMonitor Closely (1)clonazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamMonitor Closely (1)clonazepam and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneMonitor Closely (1)clonazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneMonitor Closely (1)clonazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneMonitor Closely (1)clonazepam and paliperidone both increase sedation. Use Caution/Monitor.pancuroniumMinor (1)clonazepam decreases effects of pancuronium by pharmacodynamic antagonism. Minor/Significance Unknown.papaveretumMonitor Closely (1)clonazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverineMonitor Closely (1)clonazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocineMonitor Closely (1)clonazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and clonazepam both increase sedation. Use Caution/Monitor.perampanelMonitor Closely (1)perampanel and clonazepam both increase sedation. Use Caution/Monitor.perphenazineMonitor Closely (1)clonazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineMonitor Closely (1)clonazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (2)phenobarbital and clonazepam both increase sedation. Use Caution/Monitor. phenobarbital will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phentermineMonitor Closely (1)clonazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (1)clonazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (1)clonazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinMonitor Closely (1)phenytoin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pholcodineMonitor Closely (1)clonazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozideMonitor Closely (1)clonazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)clonazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleMonitor Closely (1)posaconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pregabalinMonitor Closely (1)pregabalin, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneMonitor Closely (1)primidone and clonazepam both increase sedation. Use Caution/Monitor.prochlorperazineMonitor Closely (1)clonazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineMonitor Closely (1)promethazine and clonazepam both increase sedation. Use Caution/Monitor.propofolMonitor Closely (1)propofol and clonazepam both increase sedation. Use Caution/Monitor.propylhexedrineMonitor Closely (1)clonazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)clonazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamMonitor Closely (1)clonazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapineMonitor Closely (1)clonazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonMonitor Closely (1)clonazepam and ramelteon both increase sedation. Use Caution/Monitor.rapacuroniumMinor (1)clonazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Minor/Significance Unknown.remimazolamMonitor Closely (1)remimazolam, clonazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibMonitor Closely (1)ribociclib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinMonitor Closely (1)rifabutin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)rifabutin decreases levels of clonazepam by increasing metabolism. Minor/Significance Unknown.rifampinMonitor Closely (1)rifampin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifapentineMonitor Closely (1)rifapentine will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rimabotulinumtoxinBMinor (1)clonazepam decreases effects of rimabotulinumtoxinB by pharmacodynamic antagonism. Minor/Significance Unknown.risperidoneMonitor Closely (1)clonazepam and risperidone both increase sedation. Use Caution/Monitor.ritonavirMonitor Closely (1)ritonavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.rocuroniumMinor (1)clonazepam decreases effects of rocuronium by pharmacodynamic antagonism. Minor/Significance Unknown.rucaparibMonitor