AdultPediatricDosage Forms & Strengths capsule 20mg 40mg 60mg 80mg powder for injection 20mg Schizophrenia 20 mg PO q12hr with food initially; may be increased every other day PRN; not to exceed 80 mg q12hr Periodically assess need for maintenance; clinical trials have documented no added benefit with doses above 20 mg q12hr Acute Agitation With Schizophrenia IM: 10 mg q2hr or 20 mg q4hr; not to exceed 40 mg/day; use IM for up to 3 days, and switch to PO if continuing past this time Bipolar I Disorder Acute treatment of manic or mixed episodes; maintenance therapy as adjunct to lithium or valproate Acute treatment: 40 mg PO q12hr with food initially; on day 2, may be increased if necessary to 60-80 mg PO q12hr; adjust dose according to tolerance and efficacy within range of 40-80 mg q12hr Maintenance: Continue at same dose at which patient was initially stabilized; periodically reassess need for maintenance therapy Dosing Modifications Renal impairment: Dose adjustment not necessary with PO administration; caution required with IM administration Hepatic impairment: Use caution; drug undergoes extensive hepatic metabolism, which can increase systemic exposureDosage Forms & Strengths capsule 20mg 40mg 60mg 80mg powder for injection 20mg Tourette Syndrome (Off-label) Days 1-3: 5 mg/day Days 4-28: Titrate to 40 mg/day divided q12hrInteraction CheckerEnter a drug name and ziprasidoneNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (19)amiodaroneamiodarone and ziprasidone both increase QTc interval. Contraindicated.amisulprideamisulpride, ziprasidone. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndromeIncreases risk of neuroleptic malignant syndrome.amoxapineziprasidone and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Contraindicated.arsenic trioxidearsenic trioxide and ziprasidone both increase QTc interval. Contraindicated.citalopramziprasidone and citalopram both increase QTc interval. Contraindicated.disopyramidedisopyramide and ziprasidone both increase QTc interval. Contraindicated.escitalopramescitalopram and ziprasidone both increase QTc interval. Contraindicated.ziprasidone and escitalopram both increase QTc interval. Contraindicated.goserelingoserelin increases toxicity of ziprasidone by QTc interval. Contraindicated. Increases risk of torsades de pointes.ibutilideibutilide and ziprasidone both increase QTc interval. Contraindicated.indapamideindapamide and ziprasidone both increase QTc interval. Contraindicated.leuprolideleuprolide increases toxicity of ziprasidone by QTc interval. Contraindicated. Increases risk of torsades de pointes.pentamidinepentamidine and ziprasidone both increase QTc interval. Contraindicated.pimozidepimozide and ziprasidone both increase QTc interval. Contraindicated.procainamideprocainamide and ziprasidone both increase QTc interval. Contraindicated.quinidinequinidine and ziprasidone both increase QTc interval. Contraindicated.saquinavirziprasidone increases toxicity of saquinavir by QTc interval. Contraindicated. Potential for serious and/or life threatening reactions such as cardiac arrhythmias.sorafenibsorafenib and ziprasidone both increase QTc interval. Contraindicated.sotalolsotalol and ziprasidone both increase QTc interval. Contraindicated.toremifeneziprasidone and toremifene both increase QTc interval. Contraindicated. Concurrent use of ziprasidone with other agents that prolong QTc interval is contraindicated.Serious - Use Alternative (128)adagrasibadagrasib, ziprasidone. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.alfuzosinalfuzosin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideamisulpride and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineamitriptyline and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.amoxapineamoxapine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.anagrelideanagrelide and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.apomorphineziprasidone decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.apomorphine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.aripiprazolearipiprazole and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineartemether/lumefantrine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.asenapineasenapine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.atomoxetineatomoxetine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, ziprasidone. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.bromocriptineziprasidone decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.buprenorphinebuprenorphine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalbuprenorphine transdermal and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.cabergolineziprasidone decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.calcium/magnesium/potassium/sodium oxybatesziprasidone, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.ceritinibceritinib and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.chloroquinechloroquine increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug.chlorpromazinechlorpromazine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and ziprasidone both increase QTc interval. Contraindicated.clarithromycinclarithromycin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.clozapineclozapine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.degarelixdegarelix and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.desipraminedesipramine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.dofetilidedofetilide and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.donepezildonepezil and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.dopamineziprasidone decreases effects of dopamine by pharmacodynamic antagonism. Contraindicated.doxepindoxepin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.dronedaronedronedarone will increase the level or effect of ziprasidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.dronedarone and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.droperidoldroperidol and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.efavirenzefavirenz and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.eliglustateliglustat and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.encorafenibencorafenib and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. Encorafenib is associated with dose-dependent QTc interval prolongation. Avoid with drugs known to prolong QT interval.entrectinibziprasidone and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.epinephrineepinephrine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicepinephrine racemic and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.eribulineribulin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. Potential for enhanced QTc-prolonging effects; if concurrent use is necessary then ECG monitoring is recommended.erythromycin baseerythromycin base and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateerythromycin ethylsuccinate and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateerythromycin lactobionate and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateerythromycin stearate and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.fexinidazolefexinidazole and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.fingolimodfingolimod and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.fluconazolefluconazole and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.fluphenazinefluphenazine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.formoterolformoterol and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.gadobenategadobenate and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.gemifloxacingemifloxacin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.gilteritinibgilteritinib and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.glasdegibziprasidone and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.granisetrongranisetron and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.haloperidolhaloperidol and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.histrelinhistrelin increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.hydrocodonehydrocodone, ziprasidone. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydroxychloroquine sulfatehydroxychloroquine sulfate and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzinehydroxyzine increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.imipramineimipramine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabinotuzumab and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.isofluraneisoflurane and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.itraconazoleitraconazole and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazoleketoconazole and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.lefamulinlefamulin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.levodopaziprasidone decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug.levodopa inhaledziprasidone decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Atypical (2nd generation) antipsychotics inhibit dopamine D2 receptors in varying degrees (clozapine and quetiapine are lower risk). .levoketoconazolelevoketoconazole and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.lisurideziprasidone decreases effects of lisuride by pharmacodynamic antagonism. Contraindicated.lithiumlithium and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.lofepraminelofepramine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.lonafarnibziprasidone will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown.lorcaserinziprasidone and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.lumefantrinelumefantrine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilinemaprotiline and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.mefloquinemefloquine increases toxicity of ziprasidone by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.methyldopaziprasidone decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.metoclopramide intranasalziprasidone, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.ziprasidone increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.mirtazapinemirtazapine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibmobocertinib and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinmoxifloxacin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.nilotinibnilotinib and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.nortriptylinenortriptyline and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.octreotideoctreotide and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)octreotide (Antidote) and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.olanzapineolanzapine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasalziprasidone and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronziprasidone and ondansetron both increase