QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.homatropinehomatropine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine Ahuperzine A increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydrochlorothiazideformoterol and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.hydromorphonehydromorphone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydroxyzinehydroxyzine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hyoscyaminehyoscyamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.hyoscyamine sprayhyoscyamine spray and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.ibuprofenibuprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen IVibuprofen IV increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.iloperidoneiloperidone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor.iloperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.formoterol and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely.imipramineaclidinium and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.imipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.indapamideformoterol and indapamide both decrease serum potassium. Use Caution/Monitor.ipratropiumipratropium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.indomethacinindomethacin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.isoproterenolformoterol and isoproterenol both decrease serum potassium. Use Caution/Monitor.formoterol and isoproterenol both decrease sedation. Use Caution/Monitor.formoterol and isoproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.itraconazoleitraconazole and formoterol both increase QTc interval. Use Caution/Monitor.ketoprofenketoprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolacketorolac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolac intranasalketorolac intranasal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .ketotifen, ophthalmicketotifen, ophthalmic increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.labetalollabetalol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.labetalol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.lapatinibformoterol and lapatinib both increase QTc interval. Modify Therapy/Monitor Closely.lenvatinibformoterol and lenvatinib both increase QTc interval. Use Caution/Monitor. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs.leuprolideleuprolide increases toxicity of formoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.levalbuterolformoterol and levalbuterol both decrease serum potassium. Use Caution/Monitor.formoterol and levalbuterol both decrease sedation. Use Caution/Monitor.formoterol and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.levodopaaclidinium, levodopa. Other (see comment). Use Caution/Monitor. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .levofloxacinformoterol and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levorphanollevorphanol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lisdexamfetamineformoterol and lisdexamfetamine both decrease sedation. Use Caution/Monitor.formoterol and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.lofepramineaclidinium and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.lofepramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofexidinelofexidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapineaclidinium decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.aclidinium decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor.loxapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.loprazolamloprazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lorazepamlorazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lormetazepamlormetazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lornoxicamlornoxicam increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapineloxapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapine inhaledloxapine inhaled increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.aclidinium decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor.loxapine inhaled increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.maprotilineaclidinium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.maprotiline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.marijuanamarijuana increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meclizinemeclizine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.meclofenamatemeclofenamate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.mefenamic acidmefenamic acid increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.melatoninmelatonin increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meloxicammeloxicam increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.meperidinemeperidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meprobamatemeprobamate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaproterenolformoterol and metaproterenol both decrease serum potassium. Use Caution/Monitor.formoterol and metaproterenol both decrease sedation. Use Caution/Monitor.formoterol and metaproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methadoneformoterol and methadone both increase QTc interval. Modify Therapy/Monitor Closely.methadone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methamphetamineformoterol and methamphetamine both decrease sedation. Use Caution/Monitor.formoterol and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methscopolaminemethscopolamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.methyclothiazideformoterol and methyclothiazide both decrease serum potassium. Use Caution/Monitor.methylenedioxymethamphetamineformoterol and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.formoterol and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methylphenidateformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.metolazoneformoterol and metolazone both decrease serum potassium. Use Caution/Monitor.metoprololmetoprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.metoprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.midazolammidazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midodrineformoterol and midodrine both decrease sedation. Use Caution/Monitor.formoterol and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.mifepristonemifepristone, formoterol. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.mirtazapinemirtazapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.modafinilformoterol and modafinil both decrease sedation. Use Caution/Monitor.morphinemorphine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.motherwortmotherwort increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.moxonidinemoxonidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabilonenabilone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabumetonenabumetone increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nadololnadolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nadolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.nalbuphinenalbuphine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.naproxennaproxen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nebivololnebivolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nebivolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.neostigmineneostigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.norepinephrineformoterol and norepinephrine both decrease serum potassium. Use Caution/Monitor.formoterol and norepinephrine both decrease sedation. Use Caution/Monitor.formoterol and norepinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.nortriptylineaclidinium and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.nortriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ofloxacinformoterol and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.olanzapineaclidinium decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.aclidinium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.olanzapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.olanzapineolanzapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oliceridineaclidinium increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.olodaterol inhaledformoterol and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effectsonabotulinumtoxinAonabotulinumtoxinA and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.opium tinctureopium tincture increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.orphenadrineaclidinium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.osilodrostatosilodrostat and formoterol both increase QTc interval. Use Caution/Monitor.osimertinibosimertinib and formoterol both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.oxaliplatinoxaliplatin will increase the level or effect of formoterol by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.oxaprozinoxaprozin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxazepamoxazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxybutyninoxybutynin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin topicaloxybutynin topical and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin transdermaloxybutynin transdermal and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxycodoneoxycodone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxymorphoneoxymorphone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ozanimodozanimod and formoterol both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidonepaliperidone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.formoterol and paliperidone both increase QTc interval. Modify Therapy/Monitor Closely.paliperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pancuroniumpancuronium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.papaveretumpapaveretum increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.parecoxibparecoxib increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.paroxetineformoterol and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely.pasireotideformoterol and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.pazopanibformoterol and pazopanib both increase QTc interval. Use Caution/Monitor.penbutololpenbutolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.penbutolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.pentazocinepentazocine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pentobarbitalpentobarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.perphenazineaclidinium decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.perphenazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.perphenazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.phendimetrazineformoterol and phendimetrazine both decrease sedation. Use Caution/Monitor.formoterol and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.physostigminephysostigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenoxybenzaminephenoxybenzamine, formoterol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Hypotension, tachycardia.phentermineformoterol and phentermine both decrease sedation. Use Caution/Monitor.formoterol and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrineformoterol and phenylephrine both decrease sedation. Use Caution/Monitor.formoterol and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrine POformoterol and phenylephrine PO both decrease sedation. Use Caution/Monitor.formoterol and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.pholcodinepholcodine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pilocarpinepilocarpine increases and aclidinium decreases