AdultPediatricGeriatricDosage Forms & Strengths tablet 1mg 2.5mg 5mg 10mg elixir 2.5mg/5mL oral concentrate 5mg/mL injectable solution 2.5mg/mL (fluphenazine hydrochloride) 25mg/mL (fluphenazine decanoate) Psychotic Disorders Fluphenazine hydrochloride 2.5-10 mg/day PO divided q6-8hr initially; maintenance: 1-5 mg PO/IM divided q6-8hr; not to exceed 40 mg/day Fluphenazine decanoate 16.25-25 mg (25 mg/mL) IM/SC q2weeks; after achieving steady state, effects of a single injection may last 4-6 weeks; use caution titrating dosages; if doses >50 mg needed; use increments of 12.5 mg; not to exceed 100 mg Dosing considerations Conversion from oral hydrochloride salt to decanoate dosage form: 12.5 mg of decanoate every 3 weeks is approximately equivalent to 10 mg/day of oral hydrochloride and 12.5 mg/day IM/SC Dosing Modifications Renal impairment: Use with caution; monitor Hepatic impairment: Use with caution; monitorSafety and efficacy not established1-2.5 mg/day PO; dosage titrated according to responseInteraction CheckerEnter a drug name and fluphenazineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (11)amisulprideamisulpride, fluphenazine. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndrome.disopyramidefluphenazine and disopyramide both increase QTc interval. Contraindicated.fezolinetantfluphenazine will increase the level or effect of fezolinetant by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Fezolinetant AUC and peak plasma concentration are increased if coadministered with drugs that are weak, moderate, or strong CYP1A2 inhibitorsibutilidefluphenazine and ibutilide both increase QTc interval. Contraindicated.indapamidefluphenazine and indapamide both increase QTc interval. Contraindicated.metrizamidefluphenazine, metrizamide. Mechanism: unknown. Contraindicated. Risk of seizure. D/C phenothiazine 24h before admin. of metrizamide.pentamidinefluphenazine and pentamidine both increase QTc interval. Contraindicated.pimozidefluphenazine and pimozide both increase QTc interval. Contraindicated.procainamidefluphenazine and procainamide both increase QTc interval. Contraindicated.quinidinefluphenazine and quinidine both increase QTc interval. Contraindicated.sotalolfluphenazine and sotalol both increase QTc interval. Contraindicated.Serious - Use Alternative (94)adagrasibadagrasib, fluphenazine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.aminolevulinic acid oralaminolevulinic acid oral, fluphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.aminolevulinic acid topicalfluphenazine increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid.amiodaronefluphenazine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amitriptylinefluphenazine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amoxapinefluphenazine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.apomorphinefluphenazine decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.apomorphine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.aripiprazolearipiprazole and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxidefluphenazine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinefluphenazine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, fluphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).bromocriptinefluphenazine decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.cabergolinefluphenazine decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.calcium/magnesium/potassium/sodium oxybatesfluphenazine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.chlorpromazinechlorpromazine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinfluphenazine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipraminefluphenazine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. degarelixdegarelix and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.desipraminefluphenazine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.dofetilidefluphenazine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dopaminefluphenazine decreases effects of dopamine by pharmacodynamic antagonism. Contraindicated.dosulepinfluphenazine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.doxepinfluphenazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.dronedaronefluphenazine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolfluphenazine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.epinephrineepinephrine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicepinephrine racemic and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.erythromycin basefluphenazine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatefluphenazine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatefluphenazine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatefluphenazine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.fentanylfentanyl, fluphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalfentanyl intranasal, fluphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, fluphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, fluphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fexinidazolefexinidazole and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fluconazolefluphenazine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluphenazine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.formoterolfluphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.haloperidolfluphenazine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydrocodonehydrocodone, fluphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).hydroxychloroquine sulfatehydroxychloroquine sulfate and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.imipraminefluphenazine and imipramine both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazolefluphenazine and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lefamulinlefamulin and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.levodopafluphenazine decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug.levodopa inhaledfluphenazine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Phenothiazine/1st generation antipsychotics inhibit dopamine D2 receptors in varying degrees.levoketoconazolefluphenazine and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lisuridefluphenazine decreases effects of lisuride by pharmacodynamic antagonism. Contraindicated.lofepraminefluphenazine and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.lumefantrinefluphenazine and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilinefluphenazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.methyl aminolevulinatefluphenazine, methyl aminolevulinate. Either increases levels of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.methyldopafluphenazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.metoclopramide intranasalfluphenazine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.fluphenazine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.mirtazapinemirtazapine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibmobocertinib and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinfluphenazine and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotinibfluphenazine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.nortriptylinefluphenazine and nortriptyline both increase QTc interval. Avoid or Use Alternate Drug.octreotidefluphenazine and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)fluphenazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasalfluphenazine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronfluphenazine and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.paroxetineparoxetine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluphenazine and paroxetine both increase QTc interval. Avoid or Use Alternate Drug.perphenazinefluphenazine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.pramipexolefluphenazine decreases effects of pramipexole by pharmacodynamic antagonism. Contraindicated.prochlorperazinefluphenazine and prochlorperazine both increase QTc interval. Avoid or Use Alternate Drug.promazinefluphenazine and promazine both increase QTc interval. Avoid or Use Alternate Drug.promethazinefluphenazine and promethazine both increase QTc interval. Avoid or Use Alternate Drug.protriptylinefluphenazine and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.quinidinequinidine, fluphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive cardiac effects.ropinirolefluphenazine decreases effects of ropinirole by pharmacodynamic antagonism. Contraindicated.safinamidefluphenazine decreases effects of safinamide by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Dopamine antagonists may decrease safinamide effects and exacerbate Parkinson disease symptoms.saquinavirsaquinavir increases levels of fluphenazine by QTc interval. Avoid or Use Alternate Drug. Potential for increased toxicity. .selinexorselinexor, fluphenazine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sodium oxybatefluphenazine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death