risk of infection. Use Caution/Monitor.methadoneSerious - Use Alternative (1)hydroxychloroquine sulfate and methadone both increase QTc interval. Avoid or Use Alternate Drug.methotrexateMonitor Closely (1)hydroxychloroquine sulfate decreases levels of methotrexate by unknown mechanism. Use Caution/Monitor. Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. .mifepristoneSerious - Use Alternative (1)hydroxychloroquine sulfate and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.mirtazapineSerious - Use Alternative (1)mirtazapine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibSerious - Use Alternative (1)mobocertinib and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinSerious - Use Alternative (1)hydroxychloroquine sulfate and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.muromonab CD3Serious - Use Alternative (1)hydroxychloroquine sulfate and muromonab CD3 both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.mycophenolateSerious - Use Alternative (1)hydroxychloroquine sulfate and mycophenolate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.nilotinibSerious - Use Alternative (1)hydroxychloroquine sulfate and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.nortriptylineSerious - Use Alternative (1)hydroxychloroquine sulfate and nortriptyline both increase QTc interval. Avoid or Use Alternate Drug.octreotideSerious - Use Alternative (1)hydroxychloroquine sulfate and octreotide both increase QTc interval. Avoid or Use Alternate Drug.ofloxacinSerious - Use Alternative (1)hydroxychloroquine sulfate and ofloxacin both increase QTc interval. Avoid or Use Alternate Drug.olanzapineSerious - Use Alternative (1)hydroxychloroquine sulfate and olanzapine both increase QTc interval. Avoid or Use Alternate Drug.ondansetronSerious - Use Alternative (1)hydroxychloroquine sulfate and ondansetron both increase QTc interval. Avoid or Use Alternate Drug.osilodrostatMonitor Closely (2)osilodrostat and hydroxychloroquine sulfate both increase QTc interval. Use Caution/Monitor. hydroxychloroquine sulfate and osilodrostat both increase QTc interval. Use Caution/Monitor.osimertinibSerious - Use Alternative (1)hydroxychloroquine sulfate and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.oxaliplatinSerious - Use Alternative (1)oxaliplatin and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.ozanimodMonitor Closely (2)ozanimod, hydroxychloroquine sulfate. Either increases effects of the other by immunosuppressive effects; risk of infection. Use Caution/Monitor. Coadministration with immunosuppressive therapies may increase the risk of additive immune effects during therapy and in the weeks following administration. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs in order to avoid unintended additive immunosuppressive effects. ozanimod and hydroxychloroquine sulfate both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidoneSerious - Use Alternative (1)hydroxychloroquine sulfate and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.panobinostatSerious - Use Alternative (1)hydroxychloroquine sulfate and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.pasireotideSerious - Use Alternative (1)hydroxychloroquine sulfate and pasireotide both increase QTc interval. Avoid or Use Alternate Drug.pazopanibSerious - Use Alternative (1)hydroxychloroquine sulfate and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.pentamidineSerious - Use Alternative (1)hydroxychloroquine sulfate and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.perphenazineSerious - Use Alternative (1)hydroxychloroquine sulfate and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.pimavanserinSerious - Use Alternative (1)hydroxychloroquine sulfate and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.pimozideSerious - Use Alternative (1)hydroxychloroquine sulfate and pimozide both increase QTc interval. Avoid or Use Alternate Drug.pitolisantSerious - Use Alternative (1)hydroxychloroquine sulfate and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.pneumococcal vaccine 13-valentSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of pneumococcal vaccine 13-valent by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.pneumococcal vaccine heptavalentSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of pneumococcal vaccine heptavalent by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.pneumococcal vaccine polyvalentSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of pneumococcal vaccine polyvalent by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.ponesimodMonitor Closely (1)ponesimod and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Caution if coadministered because of additive immunosuppressive effects during such therapy and in the weeks following administration. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs to avoid unintended additive immunosuppressive effects.posaconazoleSerious - Use Alternative (1)hydroxychloroquine sulfate and posaconazole both increase QTc interval. Avoid or Use Alternate Drug.praziquantelMinor (1)hydroxychloroquine sulfate increases levels of praziquantel by unspecified interaction mechanism. Minor/Significance Unknown.primaquineSerious - Use Alternative (1)primaquine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.procainamideSerious - Use Alternative (1)hydroxychloroquine sulfate increases toxicity of procainamide by QTc interval. Avoid or Use Alternate Drug.propafenoneSerious - Use Alternative (1)hydroxychloroquine sulfate and propafenone both increase QTc interval. Avoid or Use Alternate Drug.protriptylineSerious - Use Alternative (1)hydroxychloroquine sulfate and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.quetiapineSerious - Use Alternative (1)hydroxychloroquine sulfate and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.quinidineSerious - Use Alternative (1)hydroxychloroquine sulfate and quinidine both increase QTc interval. Avoid or Use Alternate Drug.quinineSerious - Use Alternative (1)hydroxychloroquine sulfate and quinine both increase QTc interval. Avoid or Use Alternate Drug.rabies vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of rabies vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants may interfere with development of active immunity.rabies vaccine chick embryo cell derivedSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of rabies vaccine chick embryo cell derived by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.ranolazineSerious - Use Alternative (1)hydroxychloroquine sulfate and ranolazine both increase QTc interval. Avoid or Use Alternate Drug.remdesivirSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of remdesivir by unspecified interaction mechanism. Avoid or Use Alternate Drug. Coadministration not recommended owing to antagonistic effect on remdesivir?s intracellular metabolic activation and antiviral activity.ribociclibSerious - Use Alternative (2)ribociclib increases toxicity of hydroxychloroquine sulfate by QTc interval. Avoid or Use Alternate Drug. hydroxychloroquine sulfate and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.rilonaceptSerious - Use Alternative (1)hydroxychloroquine sulfate and rilonacept both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.rilpivirineSerious - Use Alternative (1)hydroxychloroquine sulfate and rilpivirine both increase QTc interval. Avoid or Use Alternate Drug.risperidoneSerious - Use Alternative (1)hydroxychloroquine sulfate and risperidone both increase QTc interval. Avoid or Use Alternate Drug.ritonavirSerious - Use Alternative (1)hydroxychloroquine sulfate and ritonavir both increase QTc interval. Avoid or Use Alternate Drug.romidepsinSerious - Use Alternative (1)hydroxychloroquine sulfate and romidepsin both increase QTc interval. Avoid or Use Alternate Drug.rotavirus oral vaccine, liveSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of rotavirus oral vaccine, live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.rubella vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of rubella vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.saquinavirSerious - Use Alternative (1)hydroxychloroquine sulfate and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.selpercatinibMonitor Closely (1)selpercatinib increases toxicity of hydroxychloroquine sulfate by QTc interval. Use Caution/Monitor.sertralineSerious - Use Alternative (1)hydroxychloroquine sulfate and sertraline both increase QTc interval. Avoid or Use Alternate Drug.sevofluraneSerious - Use Alternative (1)sevoflurane and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.siponimodMonitor Closely (1)siponimod and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Caution if coadministered because of additive immunosuppressive effects during such therapy and in the weeks following administration. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs to avoid unintended additive immunosuppressive effects.Serious - Use Alternative (1)siponimod and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.sipuleucel-TMonitor Closely (1)hydroxychloroquine sulfate decreases effects of sipuleucel-T by pharmacodynamic antagonism. Modify Therapy/Monitor Closely.sirolimusSerious - Use Alternative (1)hydroxychloroquine sulfate and sirolimus both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.smallpox (vaccinia) vaccine, liveSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of smallpox (vaccinia) vaccine, live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.sodium sulfate/?magnesium sulfate/potassium chlorideMonitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of hydroxychloroquine sulfate by QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias. .sodium sulfate/potassium sulfate/magnesium sulfateMonitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of hydroxychloroquine sulfate by QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias. .solifenacinSerious - Use Alternative (1)hydroxychloroquine sulfate and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.sorafenibSerious - Use Alternative (1)hydroxychloroquine sulfate and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.sotalolSerious - Use Alternative (1)hydroxychloroquine sulfate and sotalol both increase QTc interval. Avoid or Use Alternate Drug.sunitinibSerious - Use Alternative (1)hydroxychloroquine sulfate and sunitinib both increase QTc interval. Avoid or Use Alternate Drug.tacrolimusSerious - Use Alternative (2)hydroxychloroquine sulfate and tacrolimus both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. hydroxychloroquine sulfate and tacrolimus both increase QTc interval. Avoid or Use Alternate Drug.telavancinSerious - Use Alternative (1)hydroxychloroquine sulfate and telavancin both increase QTc interval. Avoid or Use Alternate Drug.temsirolimusSerious - Use Alternative (1)hydroxychloroquine sulfate and temsirolimus both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.tetanus toxoid adsorbed or fluidSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of tetanus toxoid adsorbed or fluid by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.tetrabenazineSerious - Use Alternative (1)hydroxychloroquine sulfate and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.thioridazineSerious - Use Alternative (1)hydroxychloroquine sulfate and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.thiothixeneSerious - Use Alternative (1)hydroxychloroquine sulfate and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.tick-borne encephalitis vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of tick-borne encephalitis vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.tisagenlecleucelSerious - Use Alternative (1)hydroxychloroquine sulfate, tisagenlecleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.tobramycin inhaledMonitor Closely (1)tobramycin inhaled and hydroxychloroquine sulfate both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicitytocilizumabSerious - Use Alternative (1)tocilizumab and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.tofacitinibSerious - Use Alternative (1)hydroxychloroquine sulfate, tofacitinib. Either increases toxicity of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.tongkat aliSerious - Use Alternative (1)hydroxychloroquine sulfate and tongkat ali both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.toremifeneSerious - Use Alternative (1)hydroxychloroquine sulfate and toremifene both increase QTc interval. Avoid or Use Alternate Drug.travelers diarrhea and cholera vaccine inactivatedSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of travelers diarrhea and cholera vaccine inactivated by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.trimipramineSerious - Use Alternative (1)hydroxychloroquine sulfate and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.typhoid polysaccharide vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of typhoid polysaccharide vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.typhoid vaccine liveSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.ublituximabMonitor Closely (1)ublituximab and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Modify Therapy/Monitor Closely. Owing to potential additive immunosuppressive effects, consider duration of effect and mechanism of action of these therapies if coadministeredustekinumabSerious - Use Alternative (1)hydroxychloroquine sulfate and ustekinumab both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.valbenazineMonitor Closely (1)valbenazine and hydroxychloroquine sulfate both increase QTc interval. Use Caution/Monitor.vandetanibSerious - Use Alternative (1)hydroxychloroquine sulfate and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.vardenafilSerious - Use Alternative (1)hydroxychloroquine sulfate and vardenafil both increase QTc interval. Avoid or Use Alternate Drug.varicella virus vaccine liveSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of varicella virus vaccine live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.vemurafenibSerious - Use Alternative (1)hydroxychloroquine sulfate and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaledSerious - Use Alternative (1)hydroxychloroquine sulfate and vilanterol/fluticasone furoate inhaled both increase QTc interval. Avoid or Use Alternate Drug.voclosporinMonitor Closely (1)voclosporin, hydroxychloroquine sulfate. Either increases effects of the other by QTc interval. Use Caution/Monitor.voriconazoleSerious - Use Alternative (1)hydroxychloroquine sulfate and voriconazole both increase QTc interval. Avoid or Use Alternate Drug.vorinostatSerious - Use Alternative (1)hydroxychloroquine sulfate and vorinostat both increase QTc interval. Avoid or Use Alternate Drug.yellow fever vaccineMinor (1)hydroxychloroquine