Caution/Monitor.benperidolbenperidol and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.benperidol and amoxapine both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, amoxapine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.benzhydrocodone/acetaminophen and amoxapine both increase sedation. Use Caution/Monitor.benzphetamineamoxapine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benztropinebenztropine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. bethanecholbethanechol increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexpiprazolebrexpiprazole and amoxapine both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and amoxapine both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and amoxapine both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and amoxapine both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and amoxapine both increase sedation. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and amoxapine both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantamoxapine, buprenorphine subdermal implant. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine subdermal implant and amoxapine both increase sedation. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and amoxapine both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionamoxapine, buprenorphine, long-acting injection. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine, long-acting injection and amoxapine both increase sedation. Use Caution/Monitor.bupropionamoxapine increases toxicity of bupropion by unspecified interaction mechanism. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible.bupropion will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.butabarbitalbutabarbital and amoxapine both increase sedation. Use Caution/Monitor.butalbitalbutalbital and amoxapine both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and amoxapine both increase sedation. Use Caution/Monitor.caffeineamoxapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbacholcarbachol increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and amoxapine both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and amoxapine both increase sedation. Use Caution/Monitor.cenobamatecenobamate, amoxapine. Either increases effects of the other by sedation. Use Caution/Monitor.cevimelinecevimeline increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydratechloral hydrate and amoxapine both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and amoxapine both increase sedation. Use Caution/Monitor.chloroquinechloroquine increases toxicity of amoxapine by QTc interval. Use Caution/Monitor.chlorpheniraminechlorpheniramine and amoxapine both increase sedation. Use Caution/Monitor.chlorpromazinechlorpromazine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.chlorpromazine and amoxapine both increase sedation. Use Caution/Monitor.chlorzoxazonechlorzoxazone and amoxapine both increase sedation. Use Caution/Monitor.cinnarizinecinnarizine and amoxapine both increase sedation. Use Caution/Monitor.cisatracuriumcisatracurium and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.citalopramcitalopram and amoxapine both increase QTc interval. Use Caution/Monitor.clemastineclemastine and amoxapine both increase sedation. Use Caution/Monitor.clobazamclobazam will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. amoxapine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineamoxapine and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and amoxapine both increase sedation. Use Caution/Monitor.clorazepateclorazepate and amoxapine both increase sedation. Use Caution/Monitor.clozapineclozapine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.clozapine and amoxapine both increase sedation. Use Caution/Monitor.clozapine and amoxapine both increase QTc interval. Use Caution/Monitor.cobicistatcobicistat will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Carefully titrate antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant responsecobicistat will increase the level or effect of amoxapine by Other (see comment). Use Caution/Monitor. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. cocaine topicalamoxapine and cocaine topical both increase serotonin levels. Modify Therapy/Monitor Closely.codeinecodeine and amoxapine both increase sedation. Use Caution/Monitor.crizotinibcrizotinib and amoxapine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.cyclizinecyclizine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclizine and amoxapine both increase sedation. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclobenzaprine and amoxapine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and amoxapine both increase sedation. Use Caution/Monitor.dantrolenedantrolene and amoxapine both increase sedation. Use Caution/Monitor.daridorexantamoxapine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darifenacindarifenacin and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.dasatinibamoxapine and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.debrisoquineamoxapine decreases effects of debrisoquine by Other (see comment). Use Caution/Monitor. Comment: Inhibition of uptake by adrenergic neurons.desfluranedesflurane and amoxapine both increase sedation. Use Caution/Monitor.desipramineamoxapine and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineamoxapine and deutetrabenazine both increase sedation. Use Caution/Monitor.deutetrabenazine and amoxapine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniraminedexchlorpheniramine and amoxapine both increase sedation. Use Caution/Monitor.dexfenfluramineamoxapine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine and dexfenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.dexmedetomidinedexmedetomidine and amoxapine both increase sedation. Use Caution/Monitor.dexmethylphenidateamoxapine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineamoxapine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.amoxapine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.dextroamphetamine transdermalamoxapine will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Modify Therapy/Monitor Closely. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Monitor frequently and adjust or use an alternant based on clinical response.dextromoramidedextromoramide and amoxapine both increase sedation. Use Caution/Monitor.diamorphinediamorphine and amoxapine both increase sedation. Use Caution/Monitor.diazepamdiazepam and amoxapine both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, amoxapine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.dicyclominedicyclomine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.diethylpropionamoxapine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and amoxapine both increase sedation. Use Caution/Monitor.difenoxin hcldifenoxin hcl and amoxapine both increase sedation. Use Caution/Monitor.dihydroergotamineamoxapine and dihydroergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.dihydroergotamine intranasalamoxapine and dihydroergotamine intranasal both increase serotonin levels. Modify Therapy/Monitor Closely.dimenhydrinatedimenhydrinate and amoxapine both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenhydramine and amoxapine both increase sedation. Use Caution/Monitor.diphenoxylate hcldiphenoxylate hcl and amoxapine both increase sedation. Use Caution/Monitor.dipipanonedipipanone and amoxapine both increase sedation. Use Caution/Monitor.dobutamineamoxapine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dofetilidedofetilide increases toxicity of amoxapine by QTc interval. Use Caution/Monitor.dolasetronamoxapine and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.donepezildonepezil increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineamoxapine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineamoxapine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinamoxapine and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and dosulepin both increase sedation. Use Caution/Monitor.doxepinamoxapine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and doxepin both increase sedation. Use Caution/Monitor.doxylaminedoxylamine and amoxapine both increase sedation. Use Caution/Monitor.droperidoldroperidol and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.droperidol and amoxapine both increase sedation. Use Caution/Monitor.echothiophate iodideechothiophate iodide increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.eletriptaneletriptan and amoxapine both increase serotonin levels. Modify Therapy/Monitor Closely.eliglustateliglustat increases levels of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.ephedrineamoxapine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine increases effects of ephedrine by unknown mechanism. Use Caution/Monitor.epinephrineamoxapine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.epinephrine inhaledamoxapine and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system.epinephrine racemicamoxapine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor.ergotamineamoxapine and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.escitalopramescitalopram increases toxicity of amoxapine by QTc interval. Use Caution/Monitor.esketamine intranasalesketamine intranasal, amoxapine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and amoxapine both increase sedation. Use Caution/Monitor.ethanolamoxapine and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and amoxapine both increase sedation. Use Caution/Monitor.ezogabineezogabine, amoxapine. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.fedratinibfedratinib will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary.fenfluramineamoxapine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapine and fenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.fenfluramine, amoxapine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome.fesoterodinefesoterodine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.flavoxateflavoxate and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.flecainideamoxapine and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.fluoxetineamoxapine and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazinefluphenazine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely.fluphenazine and amoxapine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and amoxapine both increase sedation. Use Caution/Monitor.fluvoxaminefluvoxamine and amoxapine both increase QTc interval. Modify Therapy/Monitor Closely.formoterolamoxapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.foscarnetamoxapine and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.frovatriptanfrovatriptan and amoxapine both increase serotonin levels. Modify Therapy/Monitor Closely.gabapentingabapentin, amoxapine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, amoxapine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.galantaminegalantamine increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.ganaxoloneamoxapine and ganaxolone both increase sedation. Use Caution/Monitor.glycopyrrolateglycopyrrolate and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine increases levels of glycopyrrolate by unknown mechanism. Use Caution/Monitor.glycopyrrolate inhaledglycopyrrolate inhaled and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor.glycopyrronium tosylate topicalglycopyrronium tosylate topical, amoxapine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.haloperidolhaloperidol and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely.haloperidol and amoxapine both increase sedation. Use Caution/Monitor.henbanehenbane and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.homatropinehomatropine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine Ahuperzine A