AdultPediatricDosage Forms & Strengths tablet, extended release 10mg Benign Prostatic Hyperplasia (BPH) 10 mg PO qDay taken after same mealSafety & efficacy not establishedInteraction CheckerEnter a drug name and alfuzosinNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (30)atazanaviratazanavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.ceritinibceritinib and alfuzosin both increase QTc interval. Contraindicated.chloramphenicolchloramphenicol will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.cisapridealfuzosin and cisapride both increase QTc interval. Contraindicated.clarithromycinalfuzosin and clarithromycin both increase QTc interval. Contraindicated.cobicistatcobicistat will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potential for increased alfuzosin concentrations, which can result in serious or life threatening reactions such as hypotensiondarunavirdarunavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potential for serious and/or life-threatening reactions.dronedaronealfuzosin and dronedarone both increase QTc interval. Contraindicated.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.fluconazolealfuzosin and fluconazole both increase QTc interval. Contraindicated.fosamprenavirfosamprenavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.idelalisibidelalisib will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.indinavirindinavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.itraconazoleitraconazole increases levels of alfuzosin by decreasing metabolism. Contraindicated.alfuzosin and itraconazole both increase QTc interval. Contraindicated.ketoconazoleketoconazole increases levels of alfuzosin by decreasing metabolism. Contraindicated.lefamulinlefamulin will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.levoketoconazolelevoketoconazole increases levels of alfuzosin by decreasing metabolism. Contraindicated.lopinavirlopinavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.mifepristonemifepristone will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.nefazodonenefazodone will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.nelfinavirnelfinavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.nirmatrelvirnirmatrelvir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Nirmatrelvir/ritonavir is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions.nirmatrelvir/ritonavirnirmatrelvir/ritonavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Nirmatrelvir/ritonavir is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions.ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC)ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Increased risk for hypotensioposaconazolealfuzosin and posaconazole both increase QTc interval. Contraindicated.ritonavirritonavir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.saquinavirsaquinavir increases levels of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potential for increased toxicity. .alfuzosin and saquinavir both increase QTc interval. Contraindicated.thioridazinealfuzosin and thioridazine both increase QTc interval. Contraindicated.tipranavirtipranavir increases levels of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potential for increased toxicity. Tipranavir is used with ritonavir (boosted therapy) which is a potent CYP3A4 inhibitor.voriconazolealfuzosin and voriconazole both increase QTc interval. Contraindicated.Serious - Use Alternative (82)abametapirabametapir will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.amiodaronealfuzosin and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideamisulpride and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.anagrelidealfuzosin and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.apalutamideapalutamide will decrease the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.arsenic trioxidealfuzosin and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinealfuzosin and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapinealfuzosin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug.azithromycinalfuzosin and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.buprenorphinealfuzosin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.ceritinibceritinib will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.chlorpromazinealfuzosin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.citalopramalfuzosin and citalopram both increase QTc interval. Avoid or Use Alternate Drug.crizotinibalfuzosin and crizotinib both increase QTc interval. Avoid or Use Alternate Drug.desfluranedesflurane and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug.disopyramidealfuzosin and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dofetilidealfuzosin and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.droperidolalfuzosin and droperidol both increase QTc interval. Avoid or Use Alternate Drug.efavirenzefavirenz will decrease the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.encorafenibalfuzosin and encorafenib both increase QTc interval. Avoid or Use Alternate Drug.entrectinibalfuzosin and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.enzalutamideenzalutamide will decrease the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.eribulinalfuzosin and eribulin both increase QTc interval. Avoid or Use Alternate Drug.erythromycin basealfuzosin and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatealfuzosin and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatealfuzosin and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatealfuzosin and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.etravirineetravirine will decrease the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.fexinidazolefexinidazole and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.fexinidazole will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.flecainidealfuzosin and flecainide both increase QTc interval. Avoid or Use Alternate Drug.foscarnetalfuzosin and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.glasdegibalfuzosin and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.hydroxychloroquine sulfatehydroxychloroquine sulfate and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug.alfuzosin and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.ibutilidealfuzosin and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.iloperidonealfuzosin and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabinotuzumab and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.alfuzosin and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.isofluranealfuzosin and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.isoniazidisoniazid will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.ivosidenibivosidenib and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ivosidenib will decrease the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.lofexidinealfuzosin and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.lonafarniblonafarnib will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.macimorelinmacimorelin and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.methadonealfuzosin and methadone both increase QTc interval. Avoid or Use Alternate Drug.midostaurinalfuzosin and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mifepristonemifepristone and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. Use alternatives if availablealfuzosin and mifepristone both increase QTc interval. Contraindicated.mobocertinibmobocertinib will decrease the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequentlymoxifloxacinalfuzosin and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotinibalfuzosin and nilotinib both decrease QTc interval. Avoid or Use Alternate Drug.ondansetronalfuzosin and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.osimertinibalfuzosin and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.oxaliplatinalfuzosin and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.paliperidonealfuzosin and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.panobinostatalfuzosin and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.pazopanibalfuzosin and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.pentamidinealfuzosin and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.pimavanserinalfuzosin and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.pimozidealfuzosin and pimozide both increase QTc interval. Contraindicated.pitolisantalfuzosin and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodalfuzosin and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.procainamidealfuzosin and procainamide both increase QTc interval. Avoid or Use Alternate Drug.propafenonealfuzosin and propafenone both increase QTc interval. Avoid or Use Alternate Drug.quetiapinealfuzosin and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.quinidinealfuzosin and quinidine both increase QTc interval. Avoid or Use Alternate Drug.quininealfuzosin and quinine both increase QTc interval. Avoid or Use Alternate Drug.ribociclibalfuzosin and ribociclib both increase QTc interval. Contraindicated.sevofluranealfuzosin and sevoflurane both increase QTc interval. Avoid or Use Alternate Drug.sildenafilsildenafil increases effects of alfuzosin by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr.siponimodalfuzosin and siponimod both increase QTc interval. Avoid or Use Alternate Drug.sorafenibalfuzosin and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.sotalolalfuzosin and sotalol both increase QTc interval. Avoid or Use Alternate Drug.tamsulosinalfuzosin, tamsulosin. Either increases effects of the other by additive vasodilation. Avoid or Use Alternate Drug. Risk of hypotension.tetrabenazinealfuzosin and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.toremifenealfuzosin and toremifene both increase QTc interval. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.umeclidinium bromide/vilanterol inhaledalfuzosin and umeclidinium bromide/vilanterol inhaled both increase QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiatedvandetanibalfuzosin and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.vardenafilvardenafil increases effects of alfuzosin by pharmacodynamic synergism. Contraindicated. Risk of hypotension.vemurafenibalfuzosin and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaledalfuzosin and vilanterol/fluticasone furoate inhaled both increase QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiatedvoxelotorvoxelotor will increase the level or effect of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Avoid