Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineclonazepam and clomipramine both increase sedation. Use Caution/Monitor.clonidineclonidine, clonazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Enhanced CNS depressant effects.clorazepateclonazepam and clorazepate both increase sedation. Use Caution/Monitor.clozapineclonazepam and clozapine both increase sedation. Use Caution/Monitor.cobicistatcobicistat will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Clinical monitoring is recommended upon coadministration with anticonvulsants.codeineclonazepam and codeine both increase sedation. Use Caution/Monitor.crizotinibcrizotinib increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A.crofelemercrofelemer increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.cyclizinecyclizine and clonazepam both increase sedation. Use Caution/Monitor.cyclobenzaprineclonazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and clonazepam both increase sedation. Use Caution/Monitor.dabrafenibdabrafenib will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.dantroleneclonazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantclonazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darunavirdarunavir will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.desfluranedesflurane and clonazepam both increase sedation. Use Caution/Monitor.desipramineclonazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineclonazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and clonazepam both increase sedation. Use Caution/Monitor.dexfenfluramineclonazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineclonazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateclonazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineclonazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideclonazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineclonazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamclonazepam and diazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionclonazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and clonazepam both increase sedation. Use Caution/Monitor.difenoxin hclclonazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and clonazepam both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and clonazepam both increase sedation. Use Caution/Monitor.diphenoxylate hclclonazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneclonazepam and dipipanone both increase sedation. Use Caution/Monitor.disulfiramdisulfiram increases levels of clonazepam by decreasing metabolism. Use Caution/Monitor.dobutamineclonazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineclonazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineclonazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinclonazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinclonazepam and doxepin both increase sedation. Use Caution/Monitor.doxylamineclonazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidolclonazepam and droperidol both increase sedation. Use Caution/Monitor.duvelisibduvelisib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. will increase the level or effect ofefavirenzefavirenz will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.elagolixelagolix will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.encorafenibencorafenib, clonazepam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.enzalutamideenzalutamide will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ephedrineclonazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineclonazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicclonazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, clonazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamclonazepam and estazolam both increase sedation. Use Caution/Monitor.ethanolclonazepam and ethanol both increase sedation. Use Caution/Monitor.ethinylestradiolethinylestradiol will increase the level or effect of clonazepam by Mechanism: decreasing metabolism. Use Caution/Monitor. Ethinyl estradiol may inhibit the clearance of benzodiazepines that undergo oxidation, thereby increasing serum concentrations of concomitantly administered benzodiazepines.etomidateetomidate and clonazepam both increase sedation. Use Caution/Monitor.etravirineetravirine will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fenfluramineclonazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinclonazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineclonazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamclonazepam and flurazepam both increase sedation. Use Caution/Monitor.formoterolclonazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosamprenavirfosamprenavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.fosphenytoinfosphenytoin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.gabapentingabapentin, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneclonazepam and ganaxolone both increase sedation. Use Caution/Monitor.haloperidolclonazepam and haloperidol both increase sedation. Use Caution/Monitor.hyaluronidasehyaluronidase, clonazepam. Other (see comment). Use Caution/Monitor. Comment: Drug combination has been found to be incompatible.hydromorphoneclonazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and clonazepam both increase sedation. Use Caution/Monitor.iloperidoneclonazepam and iloperidone both increase sedation. Use Caution/Monitor.iloperidone increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imipramineclonazepam and imipramine both increase sedation. Use Caution/Monitor.indinavirindinavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.isoproterenolclonazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineistradefylline will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleitraconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.kavakava and clonazepam both increase sedation. Use Caution/Monitor.ketamineketamine and clonazepam both increase sedation. Use Caution/Monitor.ketoconazoleketoconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.ketotifen, ophthalmicclonazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, clonazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantlemborexant, clonazepam. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lenacapavirlenacapavir will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. letermovirletermovir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterolclonazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levoketoconazolelevoketoconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.levonorgestrel oral/ethinylestradiol/ferrous bisglycinatelevonorgestrel oral/ethinylestradiol/ferrous bisglycinate will increase the level or effect of clonazepam by decreasing metabolism. Use Caution/Monitor. Ethinyl estradiol may inhibit the clearance of benzodiazepines that undergo oxidation, thereby increasing serum concentrations of concomitantly administered benzodiazepines.levorphanolclonazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineclonazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineclonazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineclonazepam and lofexidine both increase sedation. Use Caution/Monitor.lopinavirlopinavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Use alternatives if available. Consider lowering benzodiazepine dose.loprazolamclonazepam and loprazolam both increase sedation. Use Caution/Monitor.lorazepamclonazepam and lorazepam both increase sedation. Use Caution/Monitor.lorlatiniblorlatinib will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.lormetazepamclonazepam and lormetazepam both increase sedation. Use Caution/Monitor.loxapineclonazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledclonazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, clonazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineclonazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaclonazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninclonazepam and melatonin both increase sedation. Use Caution/Monitor.meperidineclonazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamateclonazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolclonazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneclonazepam and metaxalone both increase sedation. Use Caution/Monitor.methadoneclonazepam and methadone both increase sedation. Use Caution/Monitor.methamphetamineclonazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolclonazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineclonazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidate transdermalmethylphenidate transdermal will increase the level or effect of clonazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. midazolamclonazepam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineclonazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristonemifepristone will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.mirtazapineclonazepam and mirtazapine both increase sedation. Use Caution/Monitor.mitotanemitotane decreases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilclonazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineclonazepam and morphine both increase sedation. Use Caution/Monitor.motherwortclonazepam and motherwort both increase sedation. Use Caution/Monitor.moxonidineclonazepam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneclonazepam and nabilone both increase sedation. Use Caution/Monitor.nafcillinnafcillin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nalbuphineclonazepam and nalbuphine both increase sedation. Use Caution/Monitor.nefazodonenefazodone will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nelfinavirnelfinavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.norepinephrineclonazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineclonazepam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapineclonazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, clonazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tinctureclonazepam and opium tincture both increase sedation. Use Caution/Monitor.orlistatorlistat decreases levels of clonazepam by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of convulsions.orphenadrineclonazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamclonazepam and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneclonazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneclonazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneclonazepam