AdultPediatricGeriatricDosage Forms & Strengths nebulizer solution 0.31mg/3mL 0.63mg/3mL 1.25mg/3mL 1.25mg/0.5mL aerosol 45mcg/actuation Bronchospasm Nebulizer solution: 0.63 mg 3 times daily at intervals of 6-8 hr; may increase dose to 1.25 mg 3 times daily with close monitoring for adverse effects Aerosol: 90 mcg (2 actuations of metered-dose inhaler) q4-6hr; 1 actuation q4hr may be sufficient; not to exceed 2 actuations q4hr Dosage Modifications Hepatic impairment: Not evaluated Renal impairment: Caution when administering high doses of inhalation solutionDosage Forms & Strengths nebulizer solution 0.31mg/3mL 0.63mg/3mL 1.25mg/3mL 1.25mg/0.5mL aerosol 45mcg/actuation Bronchospasm Indicated for treatment or prevention of bronchospasm in adults, adolescents, and children ≥6 years (nebulized solution) or >4 years (HFA aerosol) with reversible obstructive airway disease Nebulizer solution <6 years: Not indicated; clinical trials with levalbuterol inhalation in this age group failed to meet the primary efficacy endpoint ≥6 to <12 years: 0.31 mg q8hr; not to exceed 0.63 mg q8hr PRN >12 years: 0.63 mg 3 times daily at intervals of 6-8 hr; may increase dose to 1.25 mg 3 times daily with close monitoring for adverse effects Aerosol <4 years: Safety and efficacy not established ≥4 years: 90 mcg (2 actuations of metered-dose inhaler) q4-6hr PRN; in some patients, 1 inhalation (45 mg of levalbuterol free base) q4hr may be sufficient Dosage Modifications Hepatic impairment: Not evaluated Renal impairment: Caution when administering high doses of inhalation solutionNebulizer solution: 0.63 mg initially in patients >65 yearsInteraction CheckerEnter a drug name and levalbuterolNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (20)amisulprideamisulpride and levalbuterol both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineamitriptyline, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amoxapineamoxapine, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.chloroquinechloroquine and levalbuterol both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.desipraminedesipramine, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.doxepindoxepin, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fexinidazolefexinidazole and levalbuterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.imipramineimipramine, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.isocarboxazidisocarboxazid increases effects of levalbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lefamulinlefamulin and levalbuterol both increase QTc interval. Avoid or Use Alternate Drug.linezolidlinezolid increases effects of levalbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lofepraminelofepramine, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.maprotilinemaprotiline, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.nortriptylinenortriptyline, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenelzinephenelzine increases effects of levalbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.protriptylineprotriptyline, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.tranylcyprominetranylcypromine increases effects of levalbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.trazodonetrazodone, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trimipraminetrimipramine, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Monitor Closely (258)acebutololacebutolol increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acebutolol decreases effects of levalbuterol by pharmacodynamic antagonism. Use Caution/Monitor.aceclofenacaceclofenac increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinacemetacin increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterolalbuterol and levalbuterol both decrease serum potassium. Use Caution/Monitor.albuterol and levalbuterol both decrease sedation. Use Caution/Monitor.albuterol and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilalfentanil increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfuzosinalfuzosin and levalbuterol both increase QTc interval. Use Caution/Monitor.alprazolamalprazolam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amilorideamiloride increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amitriptylineamitriptyline increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amobarbitalamobarbital increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineamoxapine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.apomorphineapomorphine and levalbuterol both increase QTc interval. Use Caution/Monitor.arformoterolarformoterol and levalbuterol both decrease serum potassium. Use Caution/Monitor.arformoterol and levalbuterol both decrease sedation. Use Caution/Monitor.arformoterol and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.aripiprazolearipiprazole increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazole and levalbuterol both increase QTc interval. Use Caution/Monitor.armodafinillevalbuterol and armodafinil both decrease sedation. Use Caution/Monitor.artemetherartemether and levalbuterol both increase QTc interval. Use Caution/Monitor.artemether/lumefantrineartemether/lumefantrine and levalbuterol both increase QTc interval. Use Caution/Monitor.aspirinaspirin increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalaspirin rectal increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololatenolol increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenolol decreases effects of levalbuterol by pharmacodynamic antagonism. Use Caution/Monitor.atomoxetinelevalbuterol, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .atomoxetine and levalbuterol both increase QTc interval. Use Caution/Monitor.azelastineazelastine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bedaquilinebedaquiline and levalbuterol both increase QTc interval. Use Caution/Monitor.belladonna and opiumbelladonna and opium increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazidelevalbuterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.benperidolbenperidol increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetaminelevalbuterol and benzphetamine both decrease sedation. Use Caution/Monitor.levalbuterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.betaxololbetaxolol increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.betaxolol decreases effects of levalbuterol by pharmacodynamic antagonism. Use Caution/Monitor.bisoprololbisoprolol increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprolol decreases effects of levalbuterol by pharmacodynamic antagonism. Use Caution/Monitor.brompheniraminebrompheniramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanidelevalbuterol and bumetanide both decrease serum potassium. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butabarbitalbutabarbital increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalbutalbital increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolbutorphanol increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeinelevalbuterol and caffeine both decrease sedation. Use Caution/Monitor.carbenoxolonelevalbuterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxaminecarbinoxamine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolcarvedilol increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilol decreases effects of levalbuterol by pharmacodynamic antagonism. Use Caution/Monitor.celecoxibcelecoxib increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprololceliprolol increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprolol decreases effects of levalbuterol by pharmacodynamic antagonism. Use Caution/Monitor.ceritinibceritinib and levalbuterol both increase QTc interval. Use Caution/Monitor.chloral hydratechloral hydrate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorothiazidelevalbuterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.chlorpheniraminechlorpheniramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazinechlorpromazine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorthalidonelevalbuterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.choline magnesium trisalicylatecholine magnesium trisalicylate increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .cinnarizinecinnarizine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.citalopramcitalopram and levalbuterol both increase QTc interval. Use Caution/Monitor.clarithromycinclarithromycin and levalbuterol both increase QTc interval. Use Caution/Monitor.clemastineclemastine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineclomipramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clonazepamclonazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clorazepateclorazepate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineclozapine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapine and levalbuterol both increase QTc interval. Use Caution/Monitor.codeinecodeine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.crizotinibcrizotinib and levalbuterol both increase QTc interval. Use Caution/Monitor.cyclizinecyclizine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclopenthiazidelevalbuterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.cyproheptadinecyproheptadine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dasatinibdasatinib and levalbuterol both increase QTc interval. Use Caution/Monitor.deflazacortlevalbuterol and deflazacort both decrease serum potassium. Use Caution/Monitor.degarelixdegarelix and levalbuterol both increase QTc interval. Use Caution/Monitor.desfluranedesflurane increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.desipraminedesipramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.deutetrabenazinedeutetrabenazine and levalbuterol both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniraminedexchlorpheniramine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluraminelevalbuterol and dexfenfluramine both decrease sedation. Use Caution/Monitor.levalbuterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidinedexmedetomidine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidatelevalbuterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor.levalbuterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetaminelevalbuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.levalbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramidedextromoramide increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphinediamorphine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dichlorphenamidedichlorphenamide and levalbuterol both decrease serum potassium. Use Caution/Monitor.dichlorphenamide, levalbuterol. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diclofenacdiclofenac increases and levalbuterol decreases serum potassium.