heart rate. Use Caution/Monitor.shepherd's purseshepherd's purse increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycolpirbuterol and sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.solriamfetolpirbuterol and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.sotalolsotalol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.sotalol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.spironolactonespironolactone increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.succinylcholinesuccinylcholine increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.sufentanilsufentanil increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.sulfasalazinesulfasalazine increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.sulindacsulindac increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.tapentadoltapentadol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.temazepamtemazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.terbutalinepirbuterol and terbutaline both decrease serum potassium. Use Caution/Monitor.pirbuterol and terbutaline both decrease sedation. Use Caution/Monitor.pirbuterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.thioridazinethioridazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thiothixenethiothixene increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.timololtimolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.timolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.tolfenamic acidtolfenamic acid increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.tolmetintolmetin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.tolvaptantolvaptan increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.topiramatetopiramate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.torsemidepirbuterol and torsemide both decrease serum potassium. Use Caution/Monitor.tramadoltramadol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodonetrazodone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triamterenetriamterene increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.triazolamtriazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triclofostriclofos increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trifluoperazinetrifluoperazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trimipraminetrimipramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triprolidinetriprolidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.xylometazolinepirbuterol and xylometazoline both decrease sedation. Use Caution/Monitor.pirbuterol and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.yohimbinepirbuterol and yohimbine both decrease sedation. Use Caution/Monitor.pirbuterol and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.ziconotideziconotide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziprasidoneziprasidone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (15)bendroflumethiazidepirbuterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.bumetanidepirbuterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chlorothiazidepirbuterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chlorthalidonepirbuterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.cyclopenthiazidepirbuterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.ethacrynic acidpirbuterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.eucalyptuseucalyptus increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.furosemidepirbuterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.hydrochlorothiazidepirbuterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.indapamidepirbuterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.methyclothiazidepirbuterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.metolazonepirbuterol, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.noni juicenoni juice increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.sagesage increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.torsemidepirbuterol, torsemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.acebutololMonitor Closely (2)acebutolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor. acebutolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aceclofenacMonitor Closely (1)aceclofenac increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinMonitor Closely (1)acemetacin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterolMonitor Closely (3)albuterol and pirbuterol both decrease serum potassium. Use Caution/Monitor. albuterol and pirbuterol both decrease sedation. Use Caution/Monitor. albuterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amilorideMonitor Closely (1)amiloride increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amitriptylineMonitor Closely (1)amitriptyline increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amitriptyline, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amobarbitalMonitor Closely (1)amobarbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineMonitor Closely (1)amoxapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.arformoterolMonitor Closely (3)arformoterol and pirbuterol both decrease serum potassium. Use Caution/Monitor. arformoterol and pirbuterol both decrease sedation. Use Caution/Monitor. arformoterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.aripiprazoleMonitor Closely (1)aripiprazole increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilMonitor Closely (1)pirbuterol and armodafinil both decrease sedation. Use Caution/Monitor.aspirinMonitor Closely (1)aspirin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalMonitor Closely (1)aspirin rectal increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateMonitor Closely (1)aspirin/citric acid/sodium bicarbonate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololMonitor Closely (2)atenolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor. atenolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atomoxetineMonitor Closely (1)pirbuterol, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .azelastineMonitor Closely (1)azelastine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)belladonna and opium increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazideMonitor Closely (1)pirbuterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)pirbuterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.benperidolMonitor Closely (1)benperidol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetamineMonitor Closely (2)pirbuterol and benzphetamine both decrease sedation. Use Caution/Monitor. pirbuterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.betaxololMonitor Closely (2)betaxolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor. betaxolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprololMonitor Closely (2)bisoprolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor. bisoprolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanideMonitor Closely (1)pirbuterol and bumetanide both decrease serum potassium. Use Caution/Monitor.Minor (1)pirbuterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.buprenorphine buccalMonitor Closely (1)buprenorphine buccal increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butabarbitalMonitor Closely (1)butabarbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeineMonitor Closely (1)pirbuterol and caffeine both decrease sedation. Use Caution/Monitor.carbenoxoloneMonitor Closely (1)pirbuterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxamineMonitor Closely (1)carbinoxamine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolMonitor Closely (2)carvedilol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor. carvedilol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celecoxibMonitor Closely (1)celecoxib increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprololMonitor Closely (2)celiprolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor. celiprolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydrateMonitor Closely (1)chloral hydrate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorothiazideMonitor Closely (1)pirbuterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)pirbuterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chlorpheniramineMonitor Closely (1)chlorpheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazineMonitor Closely (1)chlorpromazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorthalidoneMonitor Closely (1)pirbuterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.Minor (1)pirbuterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.choline magnesium trisalicylateMonitor Closely (1)choline magnesium trisalicylate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .cinnarizineMonitor Closely (1)cinnarizine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clemastineMonitor Closely (1)clemastine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineMonitor Closely (1)clomipramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)clomipramine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.clonazepamMonitor Closely (1)clonazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clorazepateMonitor Closely (1)clorazepate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineMonitor Closely (1)clozapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.codeineMonitor Closely (1)codeine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclizineMonitor Closely (1)cyclizine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclopenthiazideMonitor Closely (1)pirbuterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)pirbuterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.cyproheptadineMonitor Closely (1)cyproheptadine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.deflazacortMonitor Closely (1)pirbuterol and deflazacort both decrease serum potassium. Use Caution/Monitor.desipramineMonitor Closely (1)desipramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)desipramine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluramineMonitor Closely (2)pirbuterol and dexfenfluramine both decrease sedation. Use Caution/Monitor. pirbuterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidateMonitor Closely (2)pirbuterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor. pirbuterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetamineMonitor Closely (2)pirbuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor. pirbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramideMonitor Closely (1)dextromoramide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine increases and pirbuterol decreases sedation. Effect of