Caution/Monitor.oxymorphoneoxymorphone and meprobamate both increase sedation. Use Caution/Monitor.paliperidonepaliperidone and meprobamate both increase sedation. Use Caution/Monitor.papaveretumpapaveretum and meprobamate both increase sedation. Use Caution/Monitor.papaverinemeprobamate and papaverine both increase sedation. Use Caution/Monitor.pentazocinepentazocine and meprobamate both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and meprobamate both increase sedation. Use Caution/Monitor.perphenazineperphenazine and meprobamate both increase sedation. Use Caution/Monitor.phendimetrazinemeprobamate increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and meprobamate both increase sedation. Use Caution/Monitor.phenterminemeprobamate increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinemeprobamate increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POmeprobamate increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinemeprobamate and pholcodine both increase sedation. Use Caution/Monitor.pimozidepimozide and meprobamate both increase sedation. Use Caution/Monitor.pirbuterolmeprobamate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinpregabalin, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and meprobamate both increase sedation. Use Caution/Monitor.prochlorperazineprochlorperazine and meprobamate both increase sedation. Use Caution/Monitor.promethazinepromethazine and meprobamate both increase sedation. Use Caution/Monitor.propofolpropofol and meprobamate both increase sedation. Use Caution/Monitor.propylhexedrinemeprobamate increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineprotriptyline and meprobamate both increase sedation. Use Caution/Monitor.quazepamquazepam and meprobamate both increase sedation. Use Caution/Monitor.quetiapinequetiapine and meprobamate both increase sedation. Use Caution/Monitor.ramelteonmeprobamate and ramelteon both increase sedation. Use Caution/Monitor.risperidonerisperidone and meprobamate both increase sedation. Use Caution/Monitor.salmeterolmeprobamate increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapmeprobamate and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and meprobamate both increase sedation. Use Caution/Monitor.sevofluranesevoflurane and meprobamate both increase sedation. Use Caution/Monitor.shepherd's pursemeprobamate and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, meprobamate. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanilsufentanil and meprobamate both increase sedation. Use Caution/Monitor.tapentadoltapentadol and meprobamate both increase sedation. Use Caution/Monitor.temazepamtemazepam and meprobamate both increase sedation. Use Caution/Monitor.terbutalinemeprobamate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazinethioridazine and meprobamate both increase sedation. Use Caution/Monitor.thiothixenethiothixene and meprobamate both increase sedation. Use Caution/Monitor.topiramatemeprobamate and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadoltramadol and meprobamate both increase sedation. Use Caution/Monitor.trazodonetrazodone and meprobamate both increase sedation. Use Caution/Monitor.triazolamtriazolam and meprobamate both increase sedation. Use Caution/Monitor.triclofostriclofos and meprobamate both increase sedation. Use Caution/Monitor.trifluoperazinetrifluoperazine and meprobamate both increase sedation. Use Caution/Monitor.trimipraminetrimipramine and meprobamate both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and meprobamate both increase sedation. Use Caution/Monitor.xylometazolinemeprobamate increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinemeprobamate increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidemeprobamate and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneziprasidone and meprobamate both increase sedation. Use Caution/Monitor.Minor (3)brimonidinebrimonidine increases effects of meprobamate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.eucalyptuseucalyptus and meprobamate both increase sedation. Minor/Significance Unknown.sagemeprobamate and sage both increase sedation. Minor/Significance Unknown.acrivastineMonitor Closely (1)acrivastine and meprobamate both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)meprobamate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil and meprobamate both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and meprobamate both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)amitriptyline and meprobamate both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and meprobamate both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)amoxapine and meprobamate both increase sedation. Use Caution/Monitor.apomorphineMonitor Closely (1)apomorphine and meprobamate both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)meprobamate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)aripiprazole and meprobamate both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)meprobamate increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and meprobamate both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and meprobamate both increase sedation. Use Caution/Monitor.avapritinibMonitor Closely (1)avapritinib and meprobamate both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and meprobamate both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)baclofen and meprobamate both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)belladonna and opium and meprobamate both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)benperidol and meprobamate both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenMonitor Closely (1)benzhydrocodone/acetaminophen and meprobamate both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)benzhydrocodone/acetaminophen, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzphetamineMonitor Closely (1)meprobamate increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, meprobamate. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and meprobamate both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and meprobamate both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of meprobamate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and meprobamate both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and meprobamate both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)buprenorphine and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)buprenorphine buccal and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)buprenorphine subdermal implant and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine transdermalMonitor Closely (1)buprenorphine transdermal and meprobamate both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionMonitor Closely (2)meprobamate increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. buprenorphine, long-acting injection and meprobamate both increase sedation. Use Caution/Monitor.butabarbitalMonitor Closely (1)butabarbital and meprobamate both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and meprobamate both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol and meprobamate both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)meprobamate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)meprobamate, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carbinoxamineMonitor Closely (1)carbinoxamine and meprobamate both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)carisoprodol and meprobamate both increase sedation. Use Caution/Monitor.chloral hydrateMonitor Closely (1)chloral hydrate and meprobamate both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and meprobamate both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)chlorpromazine and meprobamate both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)chlorzoxazone and meprobamate both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and meprobamate both increase sedation. Use Caution/Monitor.clemastineMonitor Closely (1)clemastine and meprobamate both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)meprobamate, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)clomipramine and meprobamate both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and meprobamate both increase sedation. Use Caution/Monitor.clorazepateMonitor Closely (1)clorazepate and meprobamate both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)clozapine and meprobamate both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)codeine and meprobamate both increase sedation. Use Caution/Monitor.cyclizineMonitor Closely (1)cyclizine and meprobamate both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)cyclobenzaprine and meprobamate both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and meprobamate both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)dantrolene and meprobamate both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)meprobamate and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desipramineMonitor Closely (1)desipramine and meprobamate both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)meprobamate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine and meprobamate both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)meprobamate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)meprobamate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)dextromoramide and meprobamate both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine and meprobamate both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and meprobamate both increase sedation. Use Caution/Monitor.diethylpropionMonitor Closely (1)meprobamate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and meprobamate both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl and meprobamate both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and meprobamate both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and meprobamate both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl and meprobamate both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone and meprobamate both increase sedation. Use Caution/Monitor.dobutamineMonitor Closely (1)meprobamate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)meprobamate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)meprobamate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepinMonitor Closely (1)doxepin and meprobamate both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)doxylamine and meprobamate both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)droperidol and meprobamate both increase sedation. Use Caution/Monitor.ephedrineMonitor Closely (1)meprobamate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)meprobamate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)meprobamate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam and meprobamate both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (2)meprobamate, ethanol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive CNS depression. ethanol and meprobamate both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and meprobamate both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)eucalyptus and meprobamate both increase sedation. Minor/Significance Unknown.fenfluramineMonitor Closely (1)meprobamate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluphenazineMonitor Closely (1)fluphenazine and meprobamate both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam and meprobamate both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)meprobamate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentinMonitor Closely (1)gabapentin, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)meprobamate and ganaxolone both increase sedation. Use Caution/Monitor.haloperidolMonitor Closely (1)haloperidol and meprobamate both increase sedation. Use Caution/Monitor.hydrocodoneSerious - Use Alternative (1)hydrocodone, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)hydromorphone and meprobamate both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.iloperidoneMonitor Closely (1)iloperidone and meprobamate both increase sedation. Use Caution/Monitor.imipramineMonitor Closely (1)imipramine and meprobamate both increase sedation. Use Caution/Monitor.isoproterenolMonitor Closely (1)meprobamate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineMonitor Closely (1)ketamine and meprobamate both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicMonitor Closely (1)ketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.lasmiditanMonitor Closely (1)lasmiditan, meprobamate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantMonitor Closely (1)lemborexant, meprobamate. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive