and clorazepate both increase sedation. Use Caution/Monitor.desipramineclorazepate and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineclorazepate and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and clorazepate both increase sedation. Use Caution/Monitor.dexfenfluramineclorazepate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineclorazepate and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateclorazepate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineclorazepate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideclorazepate and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineclorazepate and diamorphine both increase sedation. Use Caution/Monitor.diazepamclorazepate and diazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionclorazepate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and clorazepate both increase sedation. Use Caution/Monitor.difenoxin hclclorazepate and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and clorazepate both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and clorazepate both increase sedation. Use Caution/Monitor.diphenoxylate hclclorazepate and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneclorazepate and dipipanone both increase sedation. Use Caution/Monitor.disulfiramdisulfiram increases levels of clorazepate by decreasing metabolism. Use Caution/Monitor.dobutamineclorazepate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineclorazepate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineclorazepate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinclorazepate and dosulepin both increase sedation. Use Caution/Monitor.doxepinclorazepate and doxepin both increase sedation. Use Caution/Monitor.doxylamineclorazepate and doxylamine both increase sedation. Use Caution/Monitor.droperidolclorazepate and droperidol both increase sedation. Use Caution/Monitor.efavirenzefavirenz will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.elagolixelagolix will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.encorafenibencorafenib, clorazepate. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.ephedrineclorazepate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineclorazepate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicclorazepate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, clorazepate. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamclorazepate and estazolam both increase sedation. Use Caution/Monitor.ethanolclorazepate and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and clorazepate both increase sedation. Use Caution/Monitor.etravirineetravirine will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fedratinibfedratinib will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.fenfluramineclorazepate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinclorazepate and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineclorazepate and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamclorazepate and flurazepam both increase sedation. Use Caution/Monitor.formoterolclorazepate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosamprenavirfosamprenavir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.fosphenytoinfosphenytoin will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.gabapentingabapentin, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneclorazepate and ganaxolone both increase sedation. Use Caution/Monitor.haloperidolclorazepate and haloperidol both increase sedation. Use Caution/Monitor.hydromorphoneclorazepate and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and clorazepate both increase sedation. Use Caution/Monitor.iloperidoneclorazepate and iloperidone both increase sedation. Use Caution/Monitor.iloperidone increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imipramineclorazepate and imipramine both increase sedation. Use Caution/Monitor.indinavirindinavir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.isoniazidisoniazid will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.isoproterenolclorazepate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineistradefylline will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleitraconazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketamineketamine and clorazepate both increase sedation. Use Caution/Monitor.ketoconazoleketoconazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.ketotifen, ophthalmicclorazepate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, clorazepate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantlemborexant, clorazepate. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lenacapavirlenacapavir will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. letermovirletermovir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterolclorazepate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levoketoconazolelevoketoconazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.levorphanolclorazepate and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineclorazepate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineclorazepate and lofepramine both increase sedation. Use Caution/Monitor.lofexidineclorazepate and lofexidine both increase sedation. Use Caution/Monitor.loprazolamclorazepate and loprazolam both increase sedation. Use Caution/Monitor.lorazepamclorazepate and lorazepam both increase sedation. Use Caution/Monitor.lormetazepamclorazepate and lormetazepam both increase sedation. Use Caution/Monitor.loxapineclorazepate and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledclorazepate and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, clorazepate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineclorazepate and maprotiline both increase sedation. Use Caution/Monitor.marijuanaclorazepate and marijuana both increase sedation. Use Caution/Monitor.melatoninclorazepate and melatonin both increase sedation. Use Caution/Monitor.meperidineclorazepate and meperidine both increase sedation. Use Caution/Monitor.meprobamateclorazepate and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolclorazepate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneclorazepate and metaxalone both increase sedation. Use Caution/Monitor.methadoneclorazepate and methadone both increase sedation. Use Caution/Monitor.methamphetamineclorazepate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolclorazepate and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineclorazepate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidate transdermalmethylphenidate transdermal will increase the level or effect of clorazepate by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. midazolamclorazepate and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineclorazepate increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineclorazepate and mirtazapine both increase sedation. Use Caution/Monitor.mitotanemitotane decreases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilclorazepate increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineclorazepate and morphine both increase sedation. Use Caution/Monitor.motherwortclorazepate and motherwort both increase sedation. Use Caution/Monitor.moxonidineclorazepate and moxonidine both increase sedation. Use Caution/Monitor.nabiloneclorazepate and nabilone both increase sedation. Use Caution/Monitor.nafcillinnafcillin will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nalbuphineclorazepate and nalbuphine both increase sedation. Use Caution/Monitor.nefazodonenefazodone will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nelfinavirnelfinavir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.norepinephrineclorazepate increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineclorazepate and nortriptyline both increase sedation. Use Caution/Monitor.olanzapineclorazepate and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, clorazepate. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tinctureclorazepate and opium tincture both increase sedation. Use Caution/Monitor.orlistatorlistat decreases levels of clorazepate by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of convulsions.orphenadrineclorazepate and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamclorazepate and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneclorazepate and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneclorazepate and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneclorazepate and paliperidone both increase sedation. Use Caution/Monitor.papaveretumclorazepate and papaveretum both increase sedation. Use Caution/Monitor.papaverineclorazepate and papaverine both increase sedation. Use Caution/Monitor.pentazocineclorazepate and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and clorazepate both increase sedation. Use Caution/Monitor.perampanelperampanel and clorazepate both increase sedation. Use Caution/Monitor.perphenazineclorazepate and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineclorazepate increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and clorazepate both increase sedation. Use Caution/Monitor.phenobarbital will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phentermineclorazepate increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineclorazepate increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POclorazepate increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinphenytoin will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pholcodineclorazepate and pholcodine both increase sedation. Use Caution/Monitor.pimozideclorazepate and pimozide both increase sedation. Use Caution/Monitor.pirbuterolclorazepate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleposaconazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pregabalinpregabalin, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and clorazepate both increase sedation. Use Caution/Monitor.primidone will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.prochlorperazineclorazepate and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and clorazepate both increase sedation. Use Caution/Monitor.propofolpropofol and clorazepate both increase sedation. Use Caution/Monitor.propylhexedrineclorazepate increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineclorazepate and protriptyline both increase sedation. Use Caution/Monitor.quazepamclorazepate and quazepam both increase sedation. Use Caution/Monitor.quetiapineclorazepate and quetiapine both increase sedation. Use Caution/Monitor.ramelteonclorazepate and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, clorazepate. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibribociclib will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinrifabutin will decrease the level or effect of clorazepate