Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.physostigmineMonitor Closely (1)bethanechol and physostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.pilocarpineMonitor Closely (1)bethanechol and pilocarpine both increase cholinergic effects/transmission. Use Caution/Monitor.pralidoximeMonitor Closely (1)bethanechol increases and pralidoxime decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.procainamideMinor (1)procainamide decreases effects of bethanechol by pharmacodynamic antagonism. Minor/Significance Unknown.propanthelineMonitor Closely (1)bethanechol increases and propantheline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)bethanechol increases and protriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pyridostigmineMonitor Closely (1)bethanechol and pyridostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.rapacuroniumMonitor Closely (1)bethanechol increases and rapacuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.rivastigmineMonitor Closely (2)bethanechol and rivastigmine both increase cholinergic effects/transmission. Use Caution/Monitor. rivastigmine and bethanechol both increase cholinergic effects/transmission. Use Caution/Monitor.rocuroniumMonitor Closely (1)bethanechol increases and rocuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.scopolamineMonitor Closely (1)bethanechol increases and scopolamine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.solifenacinMonitor Closely (1)bethanechol increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.succinylcholineMonitor Closely (1)bethanechol and succinylcholine both increase cholinergic effects/transmission. Use Caution/Monitor.tiotropiumMonitor Closely (1)bethanechol increases and tiotropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.tolterodineMonitor Closely (1)bethanechol increases and tolterodine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodoneMinor (1)bethanechol increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.trimipramineMonitor Closely (1)bethanechol increases and trimipramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.trospium chlorideMonitor Closely (1)bethanechol increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.umeclidinium bromideMonitor Closely (1)bethanechol increases and umeclidinium bromide decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor when umeclidinium bromide is coadministered with cholinergic agents.vecuroniumMonitor Closely (1)bethanechol increases and vecuronium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. Frequency Not Defined Abdominal cramps Belching Borborygmi colicky pain Bronchial constriction Diarrhea Flushing Increased gastric motility Headache Hypotension Lacrimation Miosis Nausea Vomiting Salivation Urinary urgency Contraindications Hypersensitivity, hyperthyroidism, peptic ulcer, asthma, bradycardia, hypotension, AV conduction defects, CAD vasomotor instability, vagotonia, epilepsy, Parkinsonism, GI of GU obstruction, weak bladder wall, recent urinary bladder surgery, GI resection or anastomosis, spastic GI disturbances, HTN, obstructive pulmonary disease, tartrazine sensitivity Cautions Since bethanechol contracts the bladder there is potential for influx infection if the sphincter fails to relax Pregnancy Category: C Lactation: It is not known whether this drug is excreted in milk. Because of the potential for serious adverse reactions from bethanechol chloride in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.Pregnancy Categories A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk. B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available. Mechanism of Action Stimulates parasympathetic receptors to increase bladder muscle tone, which in turn causes contraction and stimulates micturition Pharmacokinetics Onset: 30-60 min Duration: Up to 6 hr Abasorption: Variable BRAND FORM. UNIT PRICE PILL IMAGE bethanechol chloride oral- 10 mg tabletbethanechol chloride oral- 5 mg tabletbethanechol chloride oral- 25 mg tabletbethanechol chloride oral- 50 mg tabletbethanechol chloride oral- 50 mg tabletbethanechol chloride oral- 10 mg tabletbethanechol chloride oral- 5 mg tabletbethanechol chloride oral- 50 mg tabletbethanechol chloride oral- 25 mg tabletbethanechol chloride oral- 5 mg tabletbethanechol chloride oral- 25 mg tabletbethanechol chloride oral- 10 mg tabletCopyright © 2010 First DataBank, Inc.Print Patient Educationbethanechol chloride oral BETHANECHOL - ORAL (be-THAN-e-kol) COMMON BRAND NAME(S): Urecholine USES: This medication is used to treat certain bladder problems such as the inability to urinate or empty the bladder completely due to certain causes (such as surgery, bladder muscle problems). It works by helping the bladder muscle to squeeze better, thereby improving your ability to urinate. HOW TO USE: Take this medication by mouth on an empty stomach (1 hour before or 2 hours after meals) as directed by your doctor, usually 3 to 4 times daily. Taking this medication on an empty stomach will help reduce nausea/vomiting.Dosage is based on your medical condition and response to treatment.Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.Tell your doctor if your condition lasts or gets worse. SIDE EFFECTS: Dizziness, lightheadedness, nausea, vomiting, abdominal cramps/pain, diarrhea, increased saliva/urination, sweating, flushing, watery eyes, or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, fast heartbeat, severe abdominal pain.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before taking bethanechol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent stomach/intestinal/bladder surgery, stomach/intestinal problems (such as ulcers, blockage, spasms), peritonitis, blockage of the bladder, a certain nerve problem (vagotonia), overactive thyroid (hyperthyroidism), lung disease (such as asthma, chronic obstructive pulmonary disease-COPD), heart problems (such as coronary artery disease, slow heartbeat), seizures, Parkinson's disease, blood pressure problems.This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.This medication may interfere with certain lab tests (such as amylase/lipase levels), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: stomach/abdominal pain, flushing, increased saliva, sweating, nausea, vomiting. NOTES: Do not share this medication with others. MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Information last revised May 2023. Copyright(c) 2023 First Databank, Inc. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. FormularyPatient DiscountsAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.Create Your List of PlansAdding plans allows you to:View the formulary and any restrictions for each plan.Manage and view all your plans together – even plans in different states.Compare formulary status to other drugs in the same class.Access your plan list on any device – mobile or desktop. The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. View explanations for tiers and restrictions Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. 2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs. 3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs. 4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. NC NOT COVERED – Drugs that are not covered by the plan. Code Definition PA Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. 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