AdultPediatricGeriatricDosage Forms & Strengths tablet 10mg 25mg 50mg 75mg 100mg 150mg Depression 100-200 mg PO qHS or divided q12hr Up to 300 mg/day in severely ill Renal Impairment Supplemental dose not necessary in peritoneal or hemodialysis Other Indications & Uses Off-label: Postherpetic neuralgia, vulvodynia, eating disorder Dosing considerations Initial therapy may be administered in divided doses or a single daily dose Dosage should be initiated at a lower level and increased according to tolerance and clinical response Maintenance therapy may be given on a once-daily schedule for patient convenience and compliance Treatment of patients requiring as much as 300 mg should generally be initiated in hospitals, where regular visits by the physician, skilled nursing care, and frequent electrocardiograms (ECGs) are available The best available evidence of impending toxicity from very high doses is prolongation of the QRS or QT intervals on the ECG Clinical symptoms of intolerance, especially drowsiness, dizziness, and postural hypotension, should also alert the physician to the need for reduction in dosageDosage Forms & Strengths tablet 10mg 25mg 50mg 75mg 100mg 150mg Adolescents <12 years: Safety and efficacy not established Initial: 25-50 mg PO qDay; may gradually increase if needed to 100 mg/day PO qDay or divided q8-12hr Not to exceed 150 mg/day Dosing considerations Initial therapy may be administered in divided doses or a single daily dose Dosage should be initiated at a lower level and increased according to tolerance and clinical response Maintenance therapy may be given on a once-daily schedule for patient convenience and compliance The best available evidence of impending toxicity from very high doses is prolongation of the QRS or QT intervals on the ECG Clinical symptoms of intolerance, especially drowsiness, dizziness, and postural hypotension, should also alert the physician to the need for reduction in dosageDepression 25-100 mg PO qHS or divided q12hr Up to 150 mg/day in severely illInteraction CheckerEnter a drug name and desipramineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (18)disopyramidedesipramine and disopyramide both increase QTc interval. Contraindicated.eliglustatdesipramine increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given concomitantly with strong or moderate CYP3A inhibitors.ibutilidedesipramine and ibutilide both increase QTc interval. Contraindicated.indapamidedesipramine and indapamide both increase QTc interval. Contraindicated.iobenguane I 123desipramine decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Contraindicated. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results.isocarboxazidisocarboxazid and desipramine both increase serotonin levels. Contraindicated.lomitapidedesipramine increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Increases lomitapide levels several folds.pentamidinedesipramine and pentamidine both increase QTc interval. Contraindicated.phenelzinephenelzine and desipramine both increase serotonin levels. Contraindicated.pimozidedesipramine and pimozide both increase QTc interval. Contraindicated.procainamidedesipramine and procainamide both increase QTc interval. Contraindicated.procarbazineprocarbazine and desipramine both increase serotonin levels. Contraindicated. Combination is contraindicated within 2 weeks of MAOI use.quinidinequinidine and desipramine both increase QTc interval. Contraindicated.safinamidedesipramine, safinamide. Either increases toxicity of the other by serotonin levels. Contraindicated. Concomitant use could result in life-threatening serotonin syndrome.selegilineselegiline and desipramine both increase serotonin levels. Contraindicated. Concurrent use or use within 14 days of selegiline treatment is contraindicatedsotaloldesipramine and sotalol both increase QTc interval. Contraindicated.thioridazinethioridazine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.tranylcyprominetranylcypromine and desipramine both increase serotonin levels. Contraindicated.Serious - Use Alternative (145)adagrasibadagrasib, desipramine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuteroldesipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amiodaronedesipramine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amitriptylineamitriptyline and desipramine both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.amoxapineamoxapine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.arformoteroldesipramine, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.arsenic trioxidedesipramine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and desipramine both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineartemether/lumefantrine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.desipramine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.axitinibdesipramine increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If unable to avoid coadministration with moderate CYP3A4 inhibitors, monitor closely and reduce dose if necessary .benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen and desipramine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetaminedesipramine, benzphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.bosutinibdesipramine increases levels of bosutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.buprenorphinebuprenorphine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and desipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and desipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implant and desipramine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalbuprenorphine transdermal and desipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermal and desipramine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionbuprenorphine, long-acting injection and desipramine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injection and desipramine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuspironedesipramine and buspirone both increase serotonin levels. Avoid or Use Alternate Drug.calcium/magnesium/potassium/sodium oxybatesdesipramine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.chlorpromazinechlorpromazine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and desipramine both increase serotonin levels. Avoid or Use Alternate Drug. Citalopram may increase TCA levels. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Potential risk for QT prolongation. ECG monitoring is recommended.desipramine and citalopram both increase QTc interval. Avoid or Use Alternate Drug.clarithromycindesipramine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.clomipramine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.clonidinedesipramine decreases effects of clonidine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.cyclobenzaprinedesipramine and cyclobenzaprine both increase serotonin levels. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. desvenlafaxinedesipramine and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.dexfenfluraminedesipramine, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexmethylphenidatedesipramine, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextroamphetaminedesipramine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextromethorphandesipramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.diethylpropiondesipramine, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dobutaminedesipramine, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilidedesipramine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dofetilide increases toxicity of desipramine by QTc interval. Avoid or Use Alternate Drug.dolasetrondolasetron, desipramine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.dopaminedesipramine, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexaminedesipramine, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dosulepindesipramine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.desipramine and dosulepin both increase serotonin levels. Avoid or Use Alternate Drug.doxepindesipramine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.desipramine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.dronedaronedesipramine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidoldesipramine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineduloxetine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.eliglustatdesipramine increases levels of eliglustat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Moderate CYP3A4 inhibitors are not recommended with eliglustat poor or intermediate metabolizers; reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive metabolizers .encorafenibencorafenib and desipramine both increase QTc interval. Avoid or Use Alternate Drug.ephedrinedesipramine, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineepinephrine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.desipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine racemicepinephrine racemic and desipramine both increase QTc interval. Avoid or Use Alternate Drug.desipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.erythromycin basedesipramine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatedesipramine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatedesipramine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatedesipramine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramescitalopram and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.fenfluraminedesipramine, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fexinidazolefexinidazole and desipramine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fluconazoledesipramine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluoxetine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.fluphenazinefluphenazine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.fluvoxaminefluvoxamine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.formoteroldesipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.desipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the