will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.lormetazepamMonitor Closely (1)chlordiazepoxide and lormetazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)chlordiazepoxide and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)chlordiazepoxide and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, chlordiazepoxide. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineMonitor Closely (1)chlordiazepoxide and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)chlordiazepoxide and marijuana both increase sedation. Use Caution/Monitor.melatoninMonitor Closely (1)chlordiazepoxide and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)chlordiazepoxide and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)chlordiazepoxide and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)chlordiazepoxide increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)chlordiazepoxide and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)chlordiazepoxide and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)chlordiazepoxide increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)chlordiazepoxide and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)chlordiazepoxide increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metoclopramide intranasalSerious - Use Alternative (1)chlordiazepoxide, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.metyraponeMinor (1)chlordiazepoxide decreases effects of metyrapone by unspecified interaction mechanism. Minor/Significance Unknown.miconazole vaginalMinor (1)miconazole vaginal increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.midazolamMonitor Closely (1)chlordiazepoxide and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalMonitor Closely (1)midazolam intranasal, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineMonitor Closely (1)chlordiazepoxide increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineMonitor Closely (1)chlordiazepoxide and mirtazapine both increase sedation. Use Caution/Monitor.mitotaneMonitor Closely (1)mitotane decreases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilMonitor Closely (1)chlordiazepoxide increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineMonitor Closely (1)chlordiazepoxide and morphine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)chlordiazepoxide and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinMinor (1)moxifloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.moxonidineMonitor Closely (1)chlordiazepoxide and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)chlordiazepoxide and nabilone both increase sedation. Use Caution/Monitor.nafcillinMonitor Closely (1)nafcillin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nalbuphineMonitor Closely (1)chlordiazepoxide and nalbuphine both increase sedation. Use Caution/Monitor.nefazodoneSerious - Use Alternative (1)nefazodone will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.nelfinavirMonitor Closely (1)nelfinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.norepinephrineMonitor Closely (1)chlordiazepoxide increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineMonitor Closely (1)chlordiazepoxide and nortriptyline both increase sedation. Use Caution/Monitor.ofloxacinMinor (1)ofloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.olanzapineMonitor Closely (1)chlordiazepoxide and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (1)oliceridine, chlordiazepoxide. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olopatadine intranasalSerious - Use Alternative (1)chlordiazepoxide and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. omeprazoleMinor (1)omeprazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.opium tinctureMonitor Closely (1)chlordiazepoxide and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineMonitor Closely (1)chlordiazepoxide and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamMonitor Closely (1)chlordiazepoxide and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneMonitor Closely (1)chlordiazepoxide and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneMonitor Closely (1)chlordiazepoxide and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneMonitor Closely (1)chlordiazepoxide and paliperidone both increase sedation. Use Caution/Monitor.papaveretumMonitor Closely (1)chlordiazepoxide and papaveretum both increase sedation. Use Caution/Monitor.papaverineMonitor Closely (1)chlordiazepoxide and papaverine both increase sedation. Use Caution/Monitor.pentazocineMonitor Closely (1)chlordiazepoxide and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.perampanelMonitor Closely (1)perampanel and chlordiazepoxide both increase sedation. Use Caution/Monitor.perphenazineMonitor Closely (1)chlordiazepoxide and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineMonitor Closely (1)chlordiazepoxide increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (2)phenobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor. phenobarbital will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phentermineMonitor Closely (1)chlordiazepoxide increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (1)chlordiazepoxide increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (1)chlordiazepoxide increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinMonitor Closely (1)phenytoin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.pholcodineMonitor Closely (1)chlordiazepoxide and pholcodine both increase sedation. Use Caution/Monitor.pimozideMonitor Closely (1)chlordiazepoxide and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)chlordiazepoxide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleMonitor Closely (1)posaconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)posaconazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.pregabalinMonitor Closely (1)pregabalin, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneMonitor Closely (2)primidone will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. primidone and chlordiazepoxide both increase sedation. Use Caution/Monitor.prochlorperazineMonitor Closely (1)chlordiazepoxide and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineMonitor Closely (1)promethazine and chlordiazepoxide both increase sedation. Use Caution/Monitor.propofolMonitor Closely (1)propofol and chlordiazepoxide both increase sedation. Use Caution/Monitor.propylhexedrineMonitor Closely (1)chlordiazepoxide increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)chlordiazepoxide and protriptyline both increase sedation. Use Caution/Monitor.quazepamMonitor Closely (1)chlordiazepoxide and quazepam both increase sedation. Use Caution/Monitor.quetiapineMonitor Closely (1)chlordiazepoxide and quetiapine both increase sedation. Use Caution/Monitor.ramelteonMonitor Closely (1)chlordiazepoxide and ramelteon both increase sedation. Use Caution/Monitor.remimazolamMonitor Closely (1)remimazolam, chlordiazepoxide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibMonitor Closely (1)ribociclib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinMonitor Closely (1)rifabutin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)rifabutin decreases levels of chlordiazepoxide by increasing metabolism. Minor/Significance Unknown.rifampinMonitor Closely (1)rifampin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Minor (1)rifampin decreases levels of chlordiazepoxide by increasing metabolism. Minor/Significance Unknown.risperidoneMonitor Closely (1)chlordiazepoxide and risperidone both increase sedation. Use Caution/Monitor.ritonavirMonitor Closely (1)ritonavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Potential for increased toxicity. Consider lowering benzodiazepine dose.rolapitantMonitor Closely (1)rolapitant will increase the level or effect of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.rucaparibMonitor Closely (1)rucaparib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.sageMinor (1)chlordiazepoxide and sage both increase sedation. Minor/Significance Unknown.salmeterolMonitor Closely (1)chlordiazepoxide increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.saquinavirMonitor Closely (1)saquinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.scullcapMonitor Closely (1)chlordiazepoxide and scullcap both increase sedation. Use Caution/Monitor.secobarbitalMonitor Closely (2)secobarbital will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. May also enhance CNS depressant effect of chlordiazepoxide secobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.selinexorSerious - Use Alternative (1)selinexor, chlordiazepoxide. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sevofluraneMonitor Closely (1)sevoflurane and chlordiazepoxide both increase sedation. Use Caution/Monitor.shepherd's purseMonitor Closely (1)chlordiazepoxide and shepherd's purse both increase sedation. Use Caution/Monitor.sodium oxybateSerious - Use Alternative (1)chlordiazepoxide, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.stiripentolMonitor Closely (2)stiripentol, chlordiazepoxide. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. stiripentol, chlordiazepoxide. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.sufentanilMonitor Closely (1)chlordiazepoxide and sufentanil both increase sedation. Use Caution/Monitor.sufentanil SLSerious - Use Alternative (1)sufentanil SL, chlordiazepoxide. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.suvorexantMonitor Closely (1)suvorexant and chlordiazepoxide both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessarytapentadolMonitor Closely (1)chlordiazepoxide and tapentadol both increase sedation. Use Caution/Monitor.tazemetostatMonitor Closely (1)tazemetostat will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tecovirimatMonitor Closely (1)tecovirimat will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.teduglutideMonitor Closely (1)teduglutide increases levels of chlordiazepoxide by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.temazepamMonitor Closely (1)chlordiazepoxide and temazepam both increase sedation. Use Caution/Monitor.terbinafineMonitor Closely (1)terbinafine will increase the level or effect of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Assess need to reduce dose of CYP2D6-metabolized drug.terbutalineMonitor Closely (1)chlordiazepoxide increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineMonitor Closely (1)chlordiazepoxide and thioridazine both increase sedation. Use Caution/Monitor.thiothixeneMonitor Closely (1)chlordiazepoxide and thiothixene both increase sedation. Use Caution/Monitor.tipranavirMonitor Closely (1)tipranavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.topiramateMonitor Closely (1)chlordiazepoxide and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolMonitor Closely (1)chlordiazepoxide and tramadol both increase sedation. Use Caution/Monitor.trazodoneMonitor Closely (1)chlordiazepoxide and trazodone both increase sedation. Use Caution/Monitor.triazolamMonitor Closely (1)chlordiazepoxide and triazolam both increase sedation. Use Caution/Monitor.triclofosMonitor Closely (1)chlordiazepoxide and triclofos both increase sedation. Use Caution/Monitor.trifluoperazineMonitor Closely (1)chlordiazepoxide and trifluoperazine both increase sedation. Use Caution/Monitor.trimipramineMonitor Closely (1)chlordiazepoxide and trimipramine both increase sedation. Use Caution/Monitor.triprolidineMonitor Closely (1)triprolidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.tucatinibSerious - Use Alternative (1)tucatinib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose according to product labeling.valerianSerious - Use Alternative (1)valerian and chlordiazepoxide both increase sedation. Avoid or Use Alternate Drug.vinpocetineMinor (1)chlordiazepoxide increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).voriconazoleMonitor Closely (1)voriconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4