QTc interval. Modify Therapy/Monitor Closely.lefamulinSerious - Use Alternative (1)lefamulin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.lenvatinibMonitor Closely (1)formoterol and lenvatinib both increase QTc interval. Use Caution/Monitor. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs.leuprolideMonitor Closely (1)leuprolide increases toxicity of formoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.levalbuterolMonitor Closely (3)formoterol and levalbuterol both decrease serum potassium. Use Caution/Monitor. formoterol and levalbuterol both decrease sedation. Use Caution/Monitor. formoterol and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.levodopaMonitor Closely (1)aclidinium, levodopa. Other (see comment). Use Caution/Monitor. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .levofloxacinMonitor Closely (1)formoterol and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levoketoconazoleSerious - Use Alternative (1)formoterol and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levorphanolMonitor Closely (1)levorphanol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.linezolidSerious - Use Alternative (1)linezolid increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lisdexamfetamineMonitor Closely (2)formoterol and lisdexamfetamine both decrease sedation. Use Caution/Monitor. formoterol and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.lofepramineMonitor Closely (2)aclidinium and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor. lofepramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)lofepramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug. lofepramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lofexidineMonitor Closely (1)lofexidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loprazolamMonitor Closely (1)loprazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lormetazepamMonitor Closely (1)lormetazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lornoxicamMonitor Closely (1)lornoxicam increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapineMonitor Closely (4)loxapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. loxapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. aclidinium decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor. aclidinium decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.loxapine inhaledMonitor Closely (3)loxapine inhaled increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. loxapine inhaled increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. aclidinium decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor.lumefantrineSerious - Use Alternative (1)formoterol and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinSerious - Use Alternative (1)macimorelin and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilineMonitor Closely (2)aclidinium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor. maprotiline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)maprotiline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. maprotiline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.marijuanaMonitor Closely (1)marijuana increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meclizineMonitor Closely (1)meclizine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.meclofenamateMonitor Closely (1)meclofenamate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.mefenamic acidMonitor Closely (1)mefenamic acid increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.melatoninMonitor Closely (1)melatonin increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meloxicamMonitor Closely (1)meloxicam increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.meperidineMonitor Closely (1)meperidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meprobamateMonitor Closely (1)meprobamate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaproterenolMonitor Closely (3)formoterol and metaproterenol both decrease serum potassium. Use Caution/Monitor. formoterol and metaproterenol both decrease sedation. Use Caution/Monitor. formoterol and metaproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methadoneMonitor Closely (2)formoterol and methadone both increase QTc interval. Modify Therapy/Monitor Closely. methadone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methamphetamineMonitor Closely (2)formoterol and methamphetamine both decrease sedation. Use Caution/Monitor. formoterol and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methscopolamineMonitor Closely (1)methscopolamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.methyclothiazideMonitor Closely (1)formoterol and methyclothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.methylenedioxymethamphetamineMonitor Closely (2)formoterol and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor. formoterol and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methylphenidateMonitor Closely (1)formoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.metolazoneMonitor Closely (1)formoterol and metolazone both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.metoprololMonitor Closely (2)metoprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. metoprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolamMonitor Closely (1)midazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midodrineMonitor Closely (2)formoterol and midodrine both decrease sedation. Use Caution/Monitor. formoterol and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.mifepristoneMonitor Closely (1)mifepristone, formoterol. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.mirtazapineMonitor Closely (1)mirtazapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mobocertinibSerious - Use Alternative (1)mobocertinib and formoterol both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.modafinilMonitor Closely (1)formoterol and modafinil both decrease sedation. Use Caution/Monitor.morphineMonitor Closely (1)morphine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.motherwortMonitor Closely (1)motherwort increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.moxifloxacinSerious - Use Alternative (1)formoterol and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.moxonidineMonitor Closely (1)moxonidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabiloneMonitor Closely (1)nabilone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabumetoneMonitor Closely (1)nabumetone increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nadololMonitor Closely (2)nadolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. nadolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nalbuphineMonitor Closely (1)nalbuphine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.naproxenMonitor Closely (1)naproxen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nebivololMonitor Closely (2)nebivolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. nebivolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.neostigmineMonitor Closely (1)neostigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.nilotinibSerious - Use Alternative (1)formoterol and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.noni juiceMinor (1)noni juice increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.norepinephrineMonitor Closely (3)formoterol and norepinephrine both decrease serum potassium. Use Caution/Monitor. formoterol and norepinephrine both decrease sedation. Use Caution/Monitor. formoterol and norepinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.nortriptylineMonitor Closely (2)aclidinium and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. nortriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)nortriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. nortriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.octreotideSerious - Use Alternative (1)formoterol and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)Serious - Use Alternative (1)formoterol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.ofloxacinMonitor Closely (1)formoterol and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.olanzapineMonitor Closely (4)olanzapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. aclidinium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. olanzapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. aclidinium decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.oliceridineMonitor Closely (1)aclidinium increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.olodaterol inhaledMonitor Closely (1)formoterol and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effectsonabotulinumtoxinAMonitor Closely (1)onabotulinumtoxinA and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.ondansetronSerious - Use Alternative (1)formoterol and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.opium tinctureMonitor Closely (1)opium tincture increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.orphenadrineMonitor Closely (1)aclidinium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.osilodrostatMonitor Closely (1)osilodrostat and formoterol both increase QTc interval. Use Caution/Monitor.osimertinibMonitor Closely (1)osimertinib and formoterol both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.oxaliplatinMonitor Closely (1)oxaliplatin will increase the level or effect of formoterol by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.oxaprozinMonitor Closely (1)oxaprozin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxazepamMonitor Closely (1)oxazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxybutyninMonitor Closely (1)oxybutynin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin topicalMonitor Closely (1)oxybutynin topical and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin transdermalMonitor Closely (1)oxybutynin transdermal and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.oxycodoneMonitor Closely (1)oxycodone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxymorphoneMonitor Closely (1)oxymorphone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ozanimodMonitor Closely (1)ozanimod and formoterol both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidoneMonitor Closely (4)paliperidone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. aclidinium decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor. formoterol and paliperidone both increase QTc interval. Modify Therapy/Monitor Closely. paliperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pancuroniumMonitor Closely (1)pancuronium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.panobinostatSerious - Use Alternative (1)formoterol and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.papaveretumMonitor Closely (1)papaveretum increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.parecoxibMonitor Closely (1)parecoxib increases and formoterol decreases serum potassium. Effect of interaction is not