dantrolene both increase sedation. Use Caution/Monitor.daridorexantquazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluranedesflurane and quazepam both increase sedation. Use Caution/Monitor.desipraminequazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazinequazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and quazepam both increase sedation. Use Caution/Monitor.dexfenfluraminequazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinequazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidatequazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminequazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramidequazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphinequazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiazepam and quazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, quazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionquazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and quazepam both increase sedation. Use Caution/Monitor.difenoxin hclquazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and quazepam both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and quazepam both increase sedation. Use Caution/Monitor.diphenoxylate hclquazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanonequazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutaminequazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopaminequazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexaminequazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinquazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinquazepam and doxepin both increase sedation. Use Caution/Monitor.doxylaminequazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidolquazepam and droperidol both increase sedation. Use Caution/Monitor.efavirenzquazepam will increase the level or effect of efavirenz by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor.efavirenz will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.elagolixelagolix decreases levels of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.enzalutamideenzalutamide will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ephedrinequazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrinequazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicquazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, quazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and quazepam both increase sedation. Use Caution/Monitor.ethanolquazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and quazepam both increase sedation. Use Caution/Monitor.fedratinibfedratinib will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.fenfluraminequazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinquazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazinequazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and quazepam both increase sedation. Use Caution/Monitor.formoterolquazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosphenytoinfosphenytoin will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.gabapentingabapentin, quazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, quazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxolonequazepam and ganaxolone both increase sedation. Use Caution/Monitor.grapefruitgrapefruit will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.haloperidolquazepam and haloperidol both increase sedation. Use Caution/Monitor.hydromorphonequazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and quazepam both increase sedation. Use Caution/Monitor.iloperidonequazepam and iloperidone both increase sedation. Use Caution/Monitor.iloperidone increases levels of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imipraminequazepam and imipramine both increase sedation. Use Caution/Monitor.isoproterenolquazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineistradefylline will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleitraconazole will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketamineketamine and quazepam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicquazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, quazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lenacapavirlenacapavir will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates.levalbuterolquazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanolquazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetaminequazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepraminequazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidinequazepam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamloprazolam and quazepam both increase sedation. Use Caution/Monitor.lorazepamlorazepam and quazepam both increase sedation. Use Caution/Monitor.lormetazepamlormetazepam and quazepam both increase sedation. Use Caution/Monitor.loxapinequazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledquazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, quazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilinequazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaquazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninquazepam and melatonin both increase sedation. Use Caution/Monitor.meperidinequazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamatequazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolquazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonequazepam and metaxalone both increase sedation. Use Caution/Monitor.methadonequazepam and methadone both increase sedation. Use Caution/Monitor.methamphetaminequazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolquazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminequazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and quazepam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, quazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinequazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristonemifepristone will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.mirtazapinequazepam and mirtazapine both increase sedation. Use Caution/Monitor.mitotanemitotane decreases levels of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilquazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinequazepam and morphine both increase sedation. Use Caution/Monitor.motherwortquazepam and motherwort both increase sedation. Use Caution/Monitor.moxonidinequazepam and moxonidine both increase sedation. Use Caution/Monitor.nabilonequazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphinequazepam and nalbuphine both increase sedation. Use Caution/Monitor.nefazodonenefazodone will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.norepinephrinequazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinequazepam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapinequazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, quazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tincturequazepam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrinequazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamoxazepam and quazepam both increase sedation. Use Caution/Monitor.oxycodonequazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonequazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonequazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumquazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverinequazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocinequazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and quazepam both increase sedation. Use Caution/Monitor.perphenazinequazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazinequazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and quazepam both increase sedation. Use Caution/Monitor.phenobarbital will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phenterminequazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinequazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POquazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinphenytoin will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pholcodinequazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozidequazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolquazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleposaconazole will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pregabalinpregabalin, quazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and quazepam both increase sedation. Use Caution/Monitor.primidone will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.prochlorperazinequazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and quazepam both increase sedation. Use Caution/Monitor.propofolpropofol and quazepam both increase sedation. Use Caution/Monitor.propylhexedrinequazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinequazepam and protriptyline both increase sedation. Use Caution/Monitor.quetiapinequazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonquazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, quazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibribociclib will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinrifabutin will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifapentinerifapentine will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.risperidonequazepam and risperidone both increase sedation. Use Caution/Monitor.rucaparibrucaparib will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.salmeterolquazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapquazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and quazepam both increase sedation. Use Caution/Monitor.secobarbital will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. May also enhance CNS depressant effect of quazepamsevofluranesevoflurane and quazepam both increase sedation. Use Caution/Monitor.shepherd's pursequazepam and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, quazepam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.stiripentol, quazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanilquazepam and sufentanil both increase sedation. Use Caution/Monitor.tapentadolquazepam and tapentadol both increase sedation. Use Caution/Monitor.tazemetostattazemetostat will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tecovirimattecovirimat will decrease the level or effect of