AdultPediatricGeriatricDosage Forms & Strengths tablet 25mg 50mg 100mg 150mg Depression Initiate at low dose (25 mg q8-12hr) and gradually titrate upward every 5-7 days up to 200-300 mg PO qHS If dose exceeds 300 mg/day, administer in divided doses q12hr Outpatient: Not to exceed 400 mg/day Inpatient: May require higher doses, up to 600 mg/day divided q12hrNot recommendedUse caution; avoid use Depression Initiate at low dose (25 mg q8-12hr) and gradually titrate upward every 5-7 days up to 200-300 mg PO qHS If dose exceeds 300 mg/day, administer in divided doses q12hr Outpatient: Not to exceed 400 mg/day Inpatient: May require higher doses, up to 600 mg/day divided q12hrInteraction CheckerEnter a drug name and amoxapineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (17)disopyramideamoxapine and disopyramide both increase QTc interval. Contraindicated.ibutilideamoxapine and ibutilide both increase QTc interval. Contraindicated.indapamideamoxapine and indapamide both increase QTc interval. Contraindicated.iobenguane I 123amoxapine decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Contraindicated. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results.isocarboxazidisocarboxazid and amoxapine both increase serotonin levels. Contraindicated.linezolidlinezolid and amoxapine both increase serotonin levels. Contraindicated.pentamidineamoxapine and pentamidine both increase QTc interval. Contraindicated.phenelzinephenelzine and amoxapine both increase serotonin levels. Contraindicated.pimozideamoxapine and pimozide both increase QTc interval. Contraindicated.procainamideamoxapine and procainamide both increase QTc interval. Contraindicated.procarbazineprocarbazine and amoxapine both increase serotonin levels. Contraindicated. Combination is contraindicated within 2 weeks of MAOI use.quinidinequinidine and amoxapine both increase QTc interval. Contraindicated.safinamideamoxapine, safinamide. Either increases toxicity of the other by serotonin levels. Contraindicated. Concomitant use could result in life-threatening serotonin syndrome.selegilineselegiline and amoxapine both increase serotonin levels. Contraindicated. Concurrent use or use within 14 days of selegiline treatment is contraindicatedsotalolamoxapine and sotalol both increase QTc interval. Contraindicated.tranylcyprominetranylcypromine and amoxapine both increase serotonin levels. Contraindicated.ziprasidoneziprasidone and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Contraindicated.Serious - Use Alternative (134)adagrasibadagrasib, amoxapine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolamoxapine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amiodaroneamoxapine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amitriptylineamitriptyline and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.arformoterolamoxapine, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.arsenic trioxideamoxapine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineamoxapine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.benzphetamineamoxapine, benzphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.buprenorphinebuprenorphine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalbuprenorphine transdermal and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.buspironeamoxapine and buspirone both increase serotonin levels. Avoid or Use Alternate Drug.calcium/magnesium/potassium/sodium oxybatesamoxapine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.chlorpromazinechlorpromazine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug. Citalopram may increase TCA levels. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Potential risk for QT prolongation. ECG monitoring is recommended.clarithromycinamoxapine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineamoxapine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and clomipramine both increase serotonin levels. Avoid or Use Alternate Drug.clonidineamoxapine decreases effects of clonidine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.cyclobenzaprineamoxapine and cyclobenzaprine both increase serotonin levels. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. desipramineamoxapine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.desvenlafaxineamoxapine and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.dexfenfluramineamoxapine, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexmethylphenidateamoxapine, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextroamphetamineamoxapine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextromethorphanamoxapine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.diethylpropionamoxapine, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dobutamineamoxapine, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilideamoxapine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetrondolasetron, amoxapine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.donepezildonepezil and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.dopamineamoxapine, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexamineamoxapine, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dosulepinamoxapine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and dosulepin both increase serotonin levels. Avoid or Use Alternate Drug.doxepinamoxapine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.dronedaroneamoxapine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolamoxapine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineduloxetine and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.ephedrineamoxapine, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineepinephrine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine racemicepinephrine racemic and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.erythromycin baseamoxapine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateamoxapine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateamoxapine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateamoxapine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramescitalopram and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.fenfluramineamoxapine, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fexinidazolefexinidazole and amoxapine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fluconazoleamoxapine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.fluphenazinefluphenazine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.fluvoxaminefluvoxamine and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.formoterolamoxapine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.amoxapine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fosamprenavirfosamprenavir increases levels of amoxapine by decreasing metabolism. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.granisetrongranisetron, amoxapine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.guanfacineamoxapine decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.haloperidolamoxapine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydroxychloroquine sulfatehydroxychloroquine sulfate and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.imipramineamoxapine and imipramine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.iobenguane I 131amoxapine will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.isoproterenolamoxapine, isoproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ivosidenibivosidenib and amoxapine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazoleamoxapine and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levalbuterolamoxapine, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.levoketoconazoleamoxapine and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranlevomilnacipran and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.lisdexamfetamineamoxapine, lisdexamfetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lofepramineamoxapine and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and lofepramine both increase serotonin levels. Avoid or Use Alternate Drug.lumefantrineamoxapine and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and amoxapine both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilineamoxapine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and maprotiline both increase serotonin levels. Avoid or Use Alternate