AdultPediatricGeriatricDosage Forms & Strengths capsule: Schedule IV 7.5mg 15mg 22.5mg 30mg Insomnia 15-30 mg PO qHS Debilitated patients: 7.5 mg PO qHS Discontinuation: Gradually taper after extended therapy; abrupt discontinuation should be avoidedSafety and efficacy not establishedInsomnia 7.5 mg PO qHS; limit use to 10-14 days Preferred drug in elderly when benzodiazepine indicated because of lack of active metaboliteInteraction CheckerEnter a drug name and temazepamNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (2)calcium/magnesium/potassium/sodium oxybatestemazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.sodium oxybatetemazepam, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.Serious - Use Alternative (16)benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzhydrocodone/acetaminophen and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine subdermal implantbuprenorphine subdermal implant and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalbuprenorphine transdermal and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionbuprenorphine, long-acting injection and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanylfentanyl, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalfentanyl intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.hydrocodonehydrocodone, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.lemborexantlemborexant, temazepam. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.metoclopramide intranasaltemazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olopatadine intranasaltemazepam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ropeginterferon alfa 2bropeginterferon alfa 2b and temazepam both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.selinexorselinexor, temazepam. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sufentanil SLsufentanil SL, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.valerianvalerian and temazepam both increase sedation. Avoid or Use Alternate Drug.Monitor Closely (196)acrivastineacrivastine and temazepam both increase sedation. Use Caution/Monitor.albuteroltemazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentaniltemazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamalprazolam and temazepam both increase sedation. Use Caution/Monitor.amisulprideamisulpride and temazepam both increase sedation. Use Caution/Monitor.amitriptylinetemazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and temazepam both increase sedation. Use Caution/Monitor.amoxapinetemazepam and amoxapine both increase sedation. Use Caution/Monitor.apomorphinetemazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoteroltemazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoletemazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafiniltemazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineasenapine and temazepam both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and temazepam both increase sedation. Use Caution/Monitor.avapritinibavapritinib and temazepam both increase sedation. Use Caution/Monitor.azelastineazelastine and temazepam both increase sedation. Use Caution/Monitor.baclofentemazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumtemazepam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidoltemazepam and benperidol both increase sedation. Use Caution/Monitor.benzphetaminetemazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanolonebrexanolone, temazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and temazepam both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and temazepam both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and temazepam both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and temazepam both increase sedation. Use Caution/Monitor.buprenorphinetemazepam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccaltemazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implanttemazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.buprenorphine, long-acting injectiontemazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.butabarbitalbutabarbital and temazepam both increase sedation. Use Caution/Monitor.butalbitalbutalbital and temazepam both increase sedation. Use Caution/Monitor.butorphanoltemazepam and butorphanol both increase sedation. Use Caution/Monitor.caffeinetemazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and temazepam both increase sedation. Use Caution/Monitor.carisoprodoltemazepam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamatecenobamate, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydratetemazepam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and temazepam both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.chlorpromazinetemazepam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazonetemazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizinecinnarizine and temazepam both increase sedation. Use Caution/Monitor.clemastineclemastine and temazepam both increase sedation. Use Caution/Monitor.clobazamtemazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipraminetemazepam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and temazepam both increase sedation. Use Caution/Monitor.clonidineclonidine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateclorazepate and temazepam both increase sedation. Use Caution/Monitor.clozapinetemazepam and clozapine both increase sedation. Use Caution/Monitor.codeinetemazepam and codeine both increase sedation. Use Caution/Monitor.cyclizinecyclizine and temazepam both increase sedation. Use Caution/Monitor.cyclobenzaprinetemazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and temazepam both increase sedation. Use Caution/Monitor.dantrolenetemazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexanttemazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluranedesflurane and temazepam both increase sedation. Use Caution/Monitor.desipraminetemazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazinetemazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.dexfenfluraminetemazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinetemazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidatetemazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminetemazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramidetemazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphinetemazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiazepam and temazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropiontemazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and temazepam both increase sedation. Use Caution/Monitor.difenoxin hcltemazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and temazepam both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and temazepam both increase sedation. Use Caution/Monitor.diphenoxylate hcltemazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanonetemazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutaminetemazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopaminetemazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexaminetemazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepintemazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepintemazepam and doxepin both increase sedation. Use Caution/Monitor.doxylaminetemazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidoltemazepam and droperidol both increase sedation. Use Caution/Monitor.ephedrinetemazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrinetemazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemictemazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, temazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and temazepam both increase sedation. Use Caution/Monitor.ethanoltemazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and temazepam both increase sedation. Use Caution/Monitor.fenfluraminetemazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserintemazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazinetemazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and temazepam both increase sedation. Use Caution/Monitor.formoteroltemazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentingabapentin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxolonetemazepam and ganaxolone both increase sedation. Use Caution/Monitor.haloperidoltemazepam and haloperidol both increase sedation. Use Caution/Monitor.hydromorphonetemazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and temazepam both increase sedation. Use Caution/Monitor.iloperidonetemazepam and iloperidone both increase sedation. Use Caution/Monitor.imipraminetemazepam and imipramine both increase sedation. Use Caution/Monitor.isoproterenoltemazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineketamine and temazepam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmictemazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol