circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluramineMonitor Closely (2)arformoterol and dexfenfluramine both decrease sedation. Use Caution/Monitor. arformoterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidateMonitor Closely (2)arformoterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor. arformoterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetamineMonitor Closely (2)arformoterol and dextroamphetamine both decrease sedation. Use Caution/Monitor. arformoterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramideMonitor Closely (1)dextromoramide increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dichlorphenamideMonitor Closely (2)dichlorphenamide and arformoterol both decrease serum potassium. Use Caution/Monitor. dichlorphenamide, arformoterol. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diclofenacMonitor Closely (1)diclofenac increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.diethylpropionMonitor Closely (2)arformoterol and diethylpropion both decrease sedation. Use Caution/Monitor. arformoterol and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diflunisalMonitor Closely (1)diflunisal increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.digoxinMonitor Closely (1)digoxin increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.disopyramideMonitor Closely (1)arformoterol and disopyramide both increase QTc interval. Use Caution/Monitor.dobutamineMonitor Closely (3)arformoterol and dobutamine both decrease serum potassium. Use Caution/Monitor. arformoterol and dobutamine both decrease sedation. Use Caution/Monitor. arformoterol and dobutamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dofetilideMonitor Closely (1)dofetilide increases toxicity of arformoterol by QTc interval. Use Caution/Monitor.dolasetronMonitor Closely (1)arformoterol and dolasetron both increase QTc interval. Use Caution/Monitor.donepezilMonitor Closely (1)donepezil and arformoterol both increase QTc interval. Use Caution/Monitor.dopamineMonitor Closely (2)arformoterol and dopamine both decrease sedation. Use Caution/Monitor. arformoterol and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexamineMonitor Closely (3)arformoterol and dopexamine both decrease serum potassium. Use Caution/Monitor. arformoterol and dopexamine both decrease sedation. Use Caution/Monitor. arformoterol and dopexamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.doxepinMonitor Closely (2)doxepin increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. doxepin and arformoterol both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dronedaroneMonitor Closely (1)arformoterol and dronedarone both increase QTc interval. Use Caution/Monitor.droperidolMonitor Closely (2)droperidol increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and droperidol both increase QTc interval. Use Caution/Monitor.drospirenoneMonitor Closely (1)drospirenone increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.efavirenzMonitor Closely (1)efavirenz and arformoterol both increase QTc interval. Use Caution/Monitor.eliglustatMonitor Closely (1)arformoterol and eliglustat both increase QTc interval. Use Caution/Monitor.encorafenibMonitor Closely (1)arformoterol and encorafenib both increase QTc interval. Use Caution/Monitor.entrectinibMonitor Closely (1)arformoterol and entrectinib both increase QTc interval. Use Caution/Monitor.ephedrineMonitor Closely (3)arformoterol and ephedrine both decrease serum potassium. Use Caution/Monitor. arformoterol and ephedrine both decrease sedation. Use Caution/Monitor. arformoterol and ephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrineMonitor Closely (3)arformoterol and epinephrine both decrease serum potassium. Use Caution/Monitor. arformoterol and epinephrine both decrease sedation. Use Caution/Monitor. arformoterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrine racemicMonitor Closely (3)arformoterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. arformoterol and epinephrine racemic both decrease sedation. Use Caution/Monitor. arformoterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.eribulinMonitor Closely (1)arformoterol and eribulin both increase QTc interval. Use Caution/Monitor.erythromycin baseMonitor Closely (1)arformoterol and erythromycin base both increase QTc interval. Use Caution/Monitor.erythromycin ethylsuccinateMonitor Closely (1)arformoterol and erythromycin ethylsuccinate both increase QTc interval. Use Caution/Monitor.erythromycin lactobionateMonitor Closely (1)arformoterol and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor.erythromycin stearateMonitor Closely (1)arformoterol and erythromycin stearate both increase QTc interval. Use Caution/Monitor.escitalopramMonitor Closely (1)escitalopram increases toxicity of arformoterol by QTc interval. Use Caution/Monitor.esmololMonitor Closely (2)esmolol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor. esmolol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethacrynic acidMonitor Closely (1)arformoterol and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.Minor (1)arformoterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.ethanolMonitor Closely (1)ethanol increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.etodolacMonitor Closely (1)etodolac increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.eucalyptusMinor (1)eucalyptus increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.fenfluramineMonitor Closely (2)arformoterol and fenfluramine both decrease sedation. Use Caution/Monitor. arformoterol and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.fenoprofenMonitor Closely (1)fenoprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fexinidazoleMonitor Closely (1)arformoterol and fexinidazole both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)fexinidazole and arformoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fingolimodMonitor Closely (1)fingolimod and arformoterol both increase QTc interval. Use Caution/Monitor.flecainideMonitor Closely (1)arformoterol and flecainide both increase QTc interval. Use Caution/Monitor.fluconazoleMonitor Closely (1)arformoterol and fluconazole both increase QTc interval. Use Caution/Monitor.fluoxetineMonitor Closely (1)arformoterol and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazineMonitor Closely (2)fluphenazine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and fluphenazine both increase QTc interval. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurbiprofenMonitor Closely (1)flurbiprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.formoterolMonitor Closely (3)arformoterol and formoterol both decrease serum potassium. Use Caution/Monitor. arformoterol and formoterol both decrease sedation. Use Caution/Monitor. arformoterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (1)arformoterol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.foscarnetSerious - Use Alternative (1)arformoterol and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.fostemsavirMonitor Closely (1)arformoterol and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. furosemideMonitor Closely (1)arformoterol and furosemide both decrease serum potassium. Use Caution/Monitor.Minor (1)arformoterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.gemifloxacinMonitor Closely (1)arformoterol and gemifloxacin both increase QTc interval. Use Caution/Monitor.gemtuzumabMonitor Closely (1)arformoterol and gemtuzumab both increase QTc interval. Use Caution/Monitor.gentamicinMonitor Closely (1)arformoterol and gentamicin both decrease serum potassium. Use Caution/Monitor.gilteritinibMonitor Closely (1)gilteritinib and arformoterol both increase QTc interval. Use Caution/Monitor.glasdegibSerious - Use Alternative (1)arformoterol and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.goserelinMonitor Closely (1)goserelin increases toxicity of arformoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.granisetronMonitor Closely (1)arformoterol and granisetron both increase QTc interval. Use Caution/Monitor.green teaMonitor Closely (1)green tea increases effects of arformoterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.haloperidolMonitor Closely (2)haloperidol increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. haloperidol and arformoterol both increase QTc interval. Use Caution/Monitor.histrelinMonitor Closely (1)histrelin increases toxicity of arformoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.hydrochlorothiazideMonitor Closely (1)arformoterol and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)arformoterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.hydromorphoneMonitor Closely (1)hydromorphone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydroxychloroquine sulfateSerious - Use Alternative (1)hydroxychloroquine sulfate and arformoterol both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzineMonitor Closely (2)arformoterol and hydroxyzine both increase QTc interval. Use Caution/Monitor. hydroxyzine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofenMonitor Closely (1)ibuprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen IVMonitor Closely (1)ibuprofen IV increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibutilideMonitor Closely (1)arformoterol and ibutilide both increase QTc interval. Use Caution/Monitor.iloperidoneMonitor Closely (2)arformoterol and iloperidone both increase QTc interval. Use Caution/Monitor. iloperidone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.imipramineMonitor Closely (1)imipramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)imipramine, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.indacaterol, inhaledSerious - Use Alternative (1)arformoterol and indacaterol, inhaled both increase QTc interval. Avoid or Use Alternate Drug.indapamideMonitor Closely (1)arformoterol and indapamide both decrease serum potassium. Use Caution/Monitor.Minor (1)arformoterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.indomethacinMonitor Closely (1)indomethacin increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.inotuzumabSerious - Use Alternative (1)inotuzumab and arformoterol both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.isocarboxazidSerious - Use Alternative (1)isocarboxazid increases effects of arformoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.isofluraneMonitor Closely (1)arformoterol and isoflurane both increase QTc interval. Use Caution/Monitor.isoproterenolMonitor Closely (3)arformoterol and isoproterenol both decrease serum potassium. Use Caution/Monitor. arformoterol and isoproterenol both decrease sedation. Use Caution/Monitor. arformoterol and isoproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.isradipineMonitor Closely (1)arformoterol and isradipine both increase QTc interval. Use Caution/Monitor.itraconazoleMonitor Closely (1)arformoterol and itraconazole both increase QTc interval. Use Caution/Monitor.ivosidenibSerious - Use Alternative (1)ivosidenib and arformoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoprofenMonitor Closely (1)ketoprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolacMonitor Closely (1)ketorolac increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolac intranasalMonitor Closely (1)ketorolac intranasal increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .ketotifen, ophthalmicMonitor Closely (1)ketotifen, ophthalmic increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.labetalolMonitor Closely (2)labetalol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor. labetalol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.lapatinibMonitor Closely (1)arformoterol and lapatinib both increase QTc interval. Use Caution/Monitor.lefamulinSerious - Use Alternative (1)lefamulin and arformoterol both increase QTc interval. Avoid or Use Alternate Drug.lenvatinibMonitor Closely (1)arformoterol and lenvatinib both increase QTc interval. Use Caution/Monitor. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs.leuprolideMonitor Closely (1)leuprolide increases toxicity of arformoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.levalbuterolMonitor Closely (3)arformoterol and levalbuterol both decrease serum potassium. Use Caution/Monitor. arformoterol and levalbuterol both decrease sedation. Use Caution/Monitor. arformoterol and levalbuterol