hr (IM); 4 hr (transdermal) Excretion: Mainly in urine (as conjugates with small amount of unchanged drug); most estrogens are also excreted in bile and undergo enterohepatic recycling BRAND FORM. UNIT PRICE PILL IMAGE estradiol oral- 1 mg tabletestradiol oral- 2 mg tabletestradiol oral- 0.5 mg tabletestradiol oral- 1 mg tabletestradiol oral- 1 mg tabletestradiol oral- 0.5 mg tabletestradiol oral- 2 mg tabletestradiol oral- 2 mg tabletestradiol oral- 0.5 mg tabletestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.06 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.06 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.1 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.025 mg/24 hr transdermal systemestradiol transdermal- 0.0375 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.075 mg/24 hr transdermal systemestradiol transdermal- 0.05 mg/24 hr transdermal systemEstrace oral- 1 mg tabletEstrace oral- 2 mg tabletEstrace oral- 0.5 mg tabletClimara transdermal- 0.06 mg/24 hr transdermal systemClimara transdermal- 0.025 mg/24 hr transdermal systemClimara transdermal- 0.0375 mg/24 hr transdermal systemClimara transdermal- 0.1 mg/24 hr transdermal systemClimara transdermal- 0.075 mg/24 hr transdermal systemClimara transdermal- 0.05 mg/24 hr transdermal systemYuvafem vaginal- 10 mcg tabletYuvafem vaginal- 10 mcg tabletVivelle-Dot transdermal- 0.025 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.1 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.05 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.0375 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.075 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.05 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.0375 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.025 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.1 mg/24 hr transdermal systemVivelle-Dot transdermal- 0.075 mg/24 hr transdermal systemImvexxy Starter Pack vaginal- 10 mcg insertImvexxy Starter Pack vaginal- 4 mcg insertImvexxy Maintenance Pack vaginal- 10 mcg insertImvexxy Maintenance Pack vaginal- 4 mcg insertDotti transdermal- 0.05 mg/24 hr transdermal systemDotti transdermal- 0.025 mg/24 hr transdermal systemDotti transdermal- 0.1 mg/24 hr transdermal systemDotti transdermal- 0.0375 mg/24 hr transdermal systemDotti transdermal- 0.075 mg/24 hr transdermal systemEstring vaginal- 2 mg (7.5 mcg /24 hour) ringVagifem vaginal- 10 mcg tabletVagifem vaginal- 10 mcg tabletestradiol vaginal- 10 mcg tabletestradiol vaginal- 0.01 % (0.1 mg/gram) creamestradiol vaginal- 0.01 % (0.1 mg/gram) creamestradiol vaginal- 0.01 % (0.1 mg/gram) creamestradiol vaginal- 10 mcg tabletestradiol vaginal- 10 mcg tabletestradiol vaginal- 0.01 % (0.1 mg/gram) creamestradiol vaginal- 0.01 % (0.1 mg/gram) creamestradiol vaginal- 0.01 % (0.1 mg/gram) creamestradiol vaginal- 10 mcg tabletestradiol vaginal- 10 mcg tabletestradiol vaginal- 10 mcg tabletestradiol vaginal- 10 mcg tabletEstrace vaginal- 0.01 % (0.1 mg/gram) creamEstroGel transdermal- 1.25 gram/actuation gelEvamist transdermal- 1.53 mg/spray (1.7%) liquidElestrin transdermal- 0.87 gram/actuation gelElestrin transdermal- 0.87 gram/actuation gelDivigel transdermal- 0.5 mg/0.5 gram (0.1 %) gelDivigel transdermal- 0.25 mg/0.25 gram (0.1 %) gelDivigel transdermal- 1 mg/gram (0.1 %) gelDivigel transdermal- 0.5 mg/0.5 gram (0.1 %) gelDivigel transdermal- 0.25 mg/0.25 gram (0.1 %) gelDivigel transdermal- 1 mg/gram (0.1 %) gelMenostar transdermal- 14 mcg/24 hr transdermal systemMinivelle transdermal- 0.025 mg/24 hr transdermal systemMinivelle transdermal- 0.0375 mg/24 hr transdermal systemMinivelle transdermal- 0.1 mg/24 hr transdermal systemMinivelle transdermal- 0.075 mg/24 hr transdermal systemMinivelle transdermal- 0.05 mg/24 hr transdermal systemCopyright © 2010 First DataBank, Inc.Select a drug:estradiol oralestradiol transdermalestradiol vaginalPrint Patient Educationestradiol oral ESTROGENS - ORAL (ES-troe-jenz) WARNING: Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia.Estrogens can increase the risk of cancer of the uterus (endometrial cancer). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding.In postmenopausal women, estrogens, taken with or without a progestin, increase the risk of cancer of the breast/ovaries, stroke, dementia, and serious blood clots. When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks).The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. This medication should be used at the lowest effective dose and for the shortest amount of time. Discuss the use of this medication with your doctor and check with him/her regularly (for example, every 3 to 6 months) to see if you still need to take this medication. If you will be taking this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section. USES: This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure). HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth with or without food as directed by your doctor. You may take it with food or right after a meal to prevent stomach upset.If you are taking the extended-release tablets, do not crush, chew, or dissolve them. Doing so can release all of the drug at once, increasing the risk of side effects. Swallow the tablets whole.The dosage is based on your medical condition and response to treatment.Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day as directed. Follow your dosing schedule carefully. Do not increase your dose or take this medication more often or for a longer time than directed.Tell your doctor if your condition does not improve or if it worsens. SIDE EFFECTS: See also Warning section.Stomach upset, nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Tell your doctor promptly if you see the tablet in your stool.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, mental/mood changes (such as depression, memory loss), breast lumps, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding), increased or new vaginal irritation/itching/odor/discharge, severe stomach/abdominal pain, yellowing eyes/skin, dark urine, swelling hands/ankles/feet, increased thirst/urination.This medication may rarely cause serious problems from blood clots (such as heart attacks, strokes, deep vein thrombosis, pulmonary embolism). Get medical help right away if you have any serious side effects, including: chest/jaw/left arm pain, unusual sweating, sudden/severe headache, weakness on one side of the body, confusion, trouble speaking, sudden vision changes (such as partial/complete blindness), pain/redness/swelling of legs, tingling/weakness/numbness in the arms/legs, trouble breathing, coughing up blood, sudden dizziness/fainting.A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder (porphyria), mental/mood disorders (such as dementia, depression).Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are taking an estrogen product. You may need to stop this medication for a time or take special precautions.This medication may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur.Children may be more sensitive to the side effects of this drug. It may affect their growth/development. Discuss the possible effects of this medication with the doctor, and monitor your child's growth periodically.This medication should not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away.This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without