Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, lorazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineMonitor Closely (1)lorazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)lorazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninMonitor Closely (1)lorazepam and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)lorazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)lorazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)lorazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)lorazepam and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)lorazepam and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)lorazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)lorazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)lorazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidate transdermalMonitor Closely (1)methylphenidate transdermal will increase the level or effect of lorazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. metoclopramide intranasalSerious - Use Alternative (1)lorazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midazolamMonitor Closely (1)lorazepam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalMonitor Closely (1)midazolam intranasal, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineMonitor Closely (1)lorazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineMonitor Closely (1)lorazepam and mirtazapine both increase sedation. Use Caution/Monitor.modafinilMonitor Closely (1)lorazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineMonitor Closely (1)lorazepam and morphine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)lorazepam and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinMinor (1)moxifloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.moxonidineMonitor Closely (1)lorazepam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)lorazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphineMonitor Closely (1)lorazepam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrineMonitor Closely (1)lorazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineMonitor Closely (1)lorazepam and nortriptyline both increase sedation. Use Caution/Monitor.ofloxacinMinor (1)ofloxacin increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.olanzapineMonitor Closely (1)lorazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (1)oliceridine, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olopatadine intranasalSerious - Use Alternative (1)lorazepam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. omeprazoleMinor (1)omeprazole increases levels of lorazepam by decreasing metabolism. Minor/Significance Unknown.onabotulinumtoxinAMinor (1)lorazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Minor/Significance Unknown.opium tinctureMonitor Closely (1)lorazepam and opium tincture both increase sedation. Use Caution/Monitor.orlistatMonitor Closely (1)orlistat decreases levels of lorazepam by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of convulsions.orphenadrineMonitor Closely (1)lorazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamMonitor Closely (1)lorazepam and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneMonitor Closely (1)lorazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneMonitor Closely (1)lorazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneMonitor Closely (1)lorazepam and paliperidone both increase sedation. Use Caution/Monitor.pancuroniumMinor (1)lorazepam decreases effects of pancuronium by pharmacodynamic antagonism. Minor/Significance Unknown.papaveretumMonitor Closely (1)lorazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverineMonitor Closely (1)lorazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocineMonitor Closely (1)lorazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and lorazepam both increase sedation. Use Caution/Monitor.perampanelMonitor Closely (1)perampanel and lorazepam both increase sedation. Use Caution/Monitor.perphenazineMonitor Closely (1)lorazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineMonitor Closely (1)lorazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (1)phenobarbital and lorazepam both increase sedation. Use Caution/Monitor.phentermineMonitor Closely (1)lorazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (1)lorazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (1)lorazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineMonitor Closely (1)lorazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozideMonitor Closely (1)lorazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)lorazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinMonitor Closely (1)pregabalin, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneMonitor Closely (1)primidone and lorazepam both increase sedation. Use Caution/Monitor.prochlorperazineMonitor Closely (1)lorazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineMonitor Closely (1)promethazine and lorazepam both increase sedation. Use Caution/Monitor.propofolMonitor Closely (1)propofol and lorazepam both increase sedation. Use Caution/Monitor.propylhexedrineMonitor Closely (1)lorazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)lorazepam and protriptyline both increase sedation. Use Caution/Monitor.pyrimethamineMinor (1)lorazepam, pyrimethamine. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hepatotoxicity.quazepamMonitor Closely (1)lorazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapineMonitor Closely (1)lorazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonMonitor Closely (1)lorazepam and ramelteon both increase sedation. Use Caution/Monitor.rapacuroniumMinor (1)lorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Minor/Significance Unknown.remimazolamMonitor Closely (1)remimazolam, lorazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.rifabutinMinor (1)rifabutin decreases levels of lorazepam by increasing metabolism. Minor/Significance Unknown.risperidoneMonitor Closely (1)lorazepam and risperidone both increase sedation. Use Caution/Monitor.rocuroniumMinor (1)lorazepam decreases effects of rocuronium by pharmacodynamic antagonism. Minor/Significance Unknown.sageMinor (2)lorazepam and sage both increase sedation. Minor/Significance Unknown. sage decreases effects of lorazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.salmeterolMonitor Closely (1)lorazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapMonitor Closely (1)lorazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalMonitor Closely (1)secobarbital and lorazepam both increase sedation. Use Caution/Monitor.selinexorSerious - Use Alternative (1)selinexor, lorazepam. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.serdexmethylphenidate/dexmethylphenidateMinor (1)serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor/Significance Unknown.sevelamerMonitor Closely (1)sevelamer decreases levels of lorazepam by increasing elimination. Use Caution/Monitor.sevofluraneMonitor Closely (1)sevoflurane and lorazepam both increase sedation. Use Caution/Monitor.shepherd's purseMonitor Closely (1)lorazepam and shepherd's purse both increase sedation. Use Caution/Monitor.sodium oxybateSerious - Use Alternative (1)lorazepam, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.stiripentolMonitor Closely (1)stiripentol, lorazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.succinylcholineMinor (1)lorazepam decreases effects of succinylcholine by pharmacodynamic antagonism. Minor/Significance Unknown.sufentanilMonitor Closely (1)lorazepam and sufentanil both increase sedation. Use Caution/Monitor.sufentanil SLSerious - Use Alternative (1)sufentanil SL, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.suvorexantMonitor Closely (1)suvorexant and lorazepam both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessarytapentadolMonitor Closely (1)lorazepam and tapentadol both increase sedation. Use Caution/Monitor.teduglutideMonitor Closely (1)teduglutide increases levels of lorazepam by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.temazepamMonitor Closely (1)lorazepam and temazepam both increase sedation. Use Caution/Monitor.terbutalineMonitor Closely (1)lorazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineMonitor Closely (1)lorazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixeneMonitor Closely (1)lorazepam and thiothixene both increase sedation. Use Caution/Monitor.topiramateMonitor Closely (1)lorazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolMonitor Closely (1)lorazepam and tramadol both increase sedation. Use Caution/Monitor.trazodoneMonitor Closely (1)lorazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamMonitor Closely (1)lorazepam and triazolam both increase sedation. Use Caution/Monitor.triclofosMonitor Closely (1)lorazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazineMonitor Closely (1)lorazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipramineMonitor Closely (1)lorazepam and trimipramine both increase sedation. Use Caution/Monitor.triprolidineMonitor Closely (1)triprolidine and lorazepam both increase sedation. Use Caution/Monitor.valerianSerious - Use Alternative (1)valerian and lorazepam both increase sedation. Avoid or Use Alternate Drug.vecuroniumMinor (1)lorazepam decreases effects of vecuronium by pharmacodynamic antagonism. Minor/Significance Unknown.vinpocetineMinor (1)lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).xylometazolineMonitor Closely (1)lorazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbineMonitor Closely (1)lorazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotideMonitor Closely (1)lorazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneMonitor Closely (1)lorazepam and ziprasidone both increase sedation. Use Caution/Monitor.zolpidemMinor (1)zolpidem, lorazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.zotepineMonitor Closely (1)lorazepam and zotepine both increase sedation. Use Caution/Monitor. Frequency Not Defined Sedation Dizziness Unsteadiness Weakness Fatigue Drowsiness Amnesia Confusion Disorientation Depression Suicidal ideation/attempt Vertigo Ataxia Sleep apnea Asthenia Extrapyramidal symptoms Respiratory depression Tremor Convulsions/seizures Visual disturbances Dysarthria Hypotension Blood dyscrasias Change in libido Impotence Jaundice Increased bilirubin Increased liver transaminases Increase in ALP Hypersensitivity reactions Nausea Constipation Change in appetite Paradoxical reactions (anxiety, excitation, agitation, hostility, aggression, rage) Black Box Warnings Risks From Concomitant Use With Opioids Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate Limit dosages and durations to the minimum required Follow patients for signs and symptoms of respiratory depression and sedation Addiction, abuse, and misuse On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction Physical dependence can occur when taken steadily for several days to weeks, even as prescribed Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk Assess each patient’s risk prior to prescribing and monitor regularly for the development of these conditions Contraindications Documented hypersensitivity Acute narrow angle glaucoma Intra-arterial administration Severe respiratory depression Sleep apnea Use of injectable dosage form in premature infants (contains benzyl alcohol) Cautions Concomitant use of benzodiazepines, including lorazepam, and opioids may result in profound sedation, respiratory depression, coma, and death (see BBW) Advise both patients and caregivers about the risks of respiratory depression and sedation when lorazepam is used with opioids; advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined Use of benzodiazepines, including lorazepam, both used alone and in combination with other CNS depressants, may lead to potentially fatal respiratory depression Not recommended for use in patients with primary depressive disorder or