transdermal and siponimod both increase QTc interval. Avoid or Use Alternate Drug.solifenacinasenapine transdermal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.sotalolasenapine transdermal and sotalol both increase QTc interval. Avoid or Use Alternate Drug.sunitinibasenapine transdermal and sunitinib both increase QTc interval. Avoid or Use Alternate Drug.tacrolimusasenapine transdermal and tacrolimus both increase QTc interval. Avoid or Use Alternate Drug.telavancinasenapine transdermal and telavancin both increase QTc interval. Avoid or Use Alternate Drug.tetrabenazineasenapine transdermal and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.thiothixeneasenapine transdermal and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.toremifeneasenapine transdermal and toremifene both increase QTc interval. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.tramadolasenapine transdermal and tramadol both increase sedation. Avoid or Use Alternate Drug.trazodoneasenapine transdermal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.triazolamasenapine transdermal and triazolam both increase sedation. Avoid or Use Alternate Drug.triptorelinasenapine transdermal and triptorelin both increase QTc interval. Avoid or Use Alternate Drug.umeclidinium bromide/vilanterol inhaledasenapine transdermal and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiatedvandetanibasenapine transdermal and vandetanib both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommendedvardenafilasenapine transdermal and vardenafil both increase QTc interval. Avoid or Use Alternate Drug.vemurafenibasenapine transdermal and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.venlafaxineasenapine transdermal and venlafaxine both decrease QTc interval. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaledasenapine transdermal and vilanterol/fluticasone furoate inhaled both increase QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiatedvoriconazoleasenapine transdermal and voriconazole both increase QTc interval. Avoid or Use Alternate Drug.vorinostatasenapine transdermal and vorinostat both increase QTc interval. Avoid or Use Alternate Drug.ziprasidoneasenapine transdermal and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (191)acetaminophen/phenyltoloxamineasenapine transdermal and acetaminophen/phenyltoloxamine both increase sedation. Use Caution/Monitor.acrivastineacrivastine and asenapine transdermal both increase sedation. Use Caution/Monitor.albuterolasenapine transdermal and albuterol both increase QTc interval. Use Caution/Monitor.alprazolamasenapine transdermal and alprazolam both increase sedation. Use Caution/Monitor.amisulprideamisulpride and asenapine transdermal both increase sedation. Use Caution/Monitor.amitriptylineasenapine transdermal and amitriptyline both increase QTc interval. Use Caution/Monitor.asenapine transdermal and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalasenapine transdermal and amobarbital both increase sedation. Use Caution/Monitor.amoxapineasenapine transdermal and amoxapine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and amoxapine both increase sedation. Use Caution/Monitor.arformoterolasenapine transdermal and arformoterol both increase QTc interval. Use Caution/Monitor.aripiprazoleasenapine transdermal and aripiprazole both increase sedation. Use Caution/Monitor.asenapineasenapine and asenapine transdermal both increase sedation. Use Caution/Monitor.avapritinibasenapine transdermal and avapritinib both increase sedation. Use Caution/Monitor.azithromycinasenapine transdermal and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenasenapine transdermal and baclofen both increase sedation. Use Caution/Monitor.bedaquilineasenapine transdermal and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybrexanoloneasenapine transdermal and brexanolone both increase sedation. Use Caution/Monitor.brexpiprazoleasenapine transdermal and brexpiprazole both increase sedation. Use Caution/Monitor.brimonidineasenapine transdermal and brimonidine both increase sedation. Use Caution/Monitor.brivaracetamasenapine transdermal and brivaracetam both increase sedation. Use Caution/Monitor.brompheniramineasenapine transdermal and brompheniramine both increase sedation. Use Caution/Monitor.butabarbitalasenapine transdermal and butabarbital both increase sedation. Use Caution/Monitor.butalbitalasenapine transdermal and butalbital both increase sedation. Use Caution/Monitor.butorphanolasenapine transdermal and butorphanol both increase sedation. Use Caution/Monitor.carbinoxamineasenapine transdermal and carbinoxamine both increase sedation. Use Caution/Monitor.cariprazineasenapine transdermal and cariprazine both increase sedation. Use Caution/Monitor.carisoprodolasenapine transdermal and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateasenapine transdermal and cenobamate both increase sedation. Use Caution/Monitor.cetirizineasenapine transdermal and cetirizine both increase sedation. Use Caution/Monitor.chlordiazepoxideasenapine transdermal and chlordiazepoxide both increase sedation. Use Caution/Monitor.chloroquineasenapine transdermal and chloroquine both increase QTc interval. Use Caution/Monitor.chlorpheniramineasenapine transdermal and chlorpheniramine both increase sedation. Use Caution/Monitor.chlorpromazineasenapine transdermal and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneasenapine transdermal and chlorzoxazone both increase sedation. Use Caution/Monitor.ciprofloxacinasenapine transdermal and ciprofloxacin both increase QTc interval. Use Caution/Monitor.citalopramasenapine transdermal and citalopram both increase QTc interval. Use Caution/Monitor.clemastineasenapine transdermal and clemastine both increase sedation. Use Caution/Monitor.clobazamasenapine transdermal and clobazam both increase sedation. Use Caution/Monitor.clomipramineasenapine transdermal and clomipramine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and clomipramine both increase sedation. Use Caution/Monitor.clonazepamasenapine transdermal and clonazepam both increase sedation. Use Caution/Monitor.clonidineasenapine transdermal and clonidine both increase sedation. Use Caution/Monitor.clorazepateasenapine transdermal and clorazepate both increase sedation. Use Caution/Monitor.clozapineasenapine transdermal and clozapine both increase sedation. Use Caution/Monitor.crizotinibasenapine transdermal and crizotinib both increase QTc interval. Use Caution/Monitor.cyclobenzaprineasenapine transdermal and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineasenapine transdermal and cyproheptadine both increase sedation. Use Caution/Monitor.dantroleneasenapine transdermal and dantrolene both increase sedation. Use Caution/Monitor.daridorexantasenapine transdermal and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluraneasenapine transdermal and desflurane both increase sedation. Use Caution/Monitor.desipramineasenapine transdermal and desipramine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineasenapine transdermal and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).asenapine transdermal and deutetrabenazine both increase sedation. Use Caution/Monitor.dexbrompheniramineasenapine transdermal and dexbrompheniramine both increase sedation. Use Caution/Monitor.dexchlorpheniramineasenapine transdermal and dexchlorpheniramine both increase sedation. Use Caution/Monitor.diazepamasenapine transdermal and diazepam both increase sedation. Use Caution/Monitor.difelikefalindifelikefalin and asenapine transdermal both increase sedation. Use Caution/Monitor.difenoxin hclasenapine transdermal and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateasenapine transdermal and dimenhydrinate both increase sedation. Use Caution/Monitor.diphenhydramineasenapine transdermal and diphenhydramine both increase sedation. Use Caution/Monitor.diphenoxylate hclasenapine transdermal and diphenoxylate hcl both increase sedation. Use Caution/Monitor.doxepinasenapine transdermal and doxepin both increase QTc interval. Use Caution/Monitor.asenapine transdermal and doxepin both increase sedation. Use Caution/Monitor.doxylamineasenapine transdermal and doxylamine both increase sedation. Use Caution/Monitor.droperidolasenapine transdermal and droperidol both increase sedation. Use Caution/Monitor.efavirenzasenapine transdermal and efavirenz both increase sedation. Use Caution/Monitor.entacaponeasenapine transdermal and entacapone both increase sedation. Use Caution/Monitor.esketamine intranasalasenapine transdermal and esketamine intranasal both increase sedation. Use Caution/Monitor.estazolamasenapine transdermal and estazolam both increase sedation. Use Caution/Monitor.eszopicloneasenapine transdermal and eszopiclone both increase sedation. Use Caution/Monitor.ethanolasenapine transdermal and ethanol both increase sedation. Use Caution/Monitor.ethosuximideasenapine transdermal and ethosuximide both increase sedation. Use Caution/Monitor.ethotoinasenapine transdermal and ethotoin both increase sedation. Use Caution/Monitor.ezogabineasenapine transdermal and ezogabine both increase QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed, particularly when dose titrated to 1200mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.felbamateasenapine transdermal and felbamate both increase sedation. Use Caution/Monitor.fenfluramineasenapine transdermal decreases effects of fenfluramine by pharmacodynamic antagonism. Use Caution/Monitor. Potent serotonin receptor antagonists may decrease fenfluramine efficacy. If coadministered, monitor appropriately.asenapine transdermal and fenfluramine both increase sedation. Use Caution/Monitor.fexofenadineasenapine transdermal and fexofenadine both increase sedation. Use Caution/Monitor.flibanserinasenapine transdermal and flibanserin both increase sedation. Use Caution/Monitor.fluoxetineasenapine transdermal and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazineasenapine transdermal and fluphenazine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamasenapine transdermal and flurazepam both increase sedation. Use Caution/Monitor.fluvoxaminefluvoxamine will increase the level or effect of asenapine transdermal by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Dose reduction may be necessaryformoterolasenapine transdermal and formoterol both increase QTc interval. Use Caution/Monitor.fostemsavirasenapine transdermal and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.gabapentinasenapine transdermal and gabapentin both increase sedation. Use Caution/Monitor.ganaxoloneasenapine transdermal and ganaxolone both increase sedation. Use Caution/Monitor.gemtuzumabasenapine transdermal and gemtuzumab both increase QTc interval. Use Caution/Monitor.guanfacineasenapine transdermal and guanfacine both increase sedation. Use Caution/Monitor.haloperidolasenapine transdermal and haloperidol both increase QTc interval. Use Caution/Monitor.asenapine transdermal and haloperidol both increase sedation. Use Caution/Monitor.hydroxyzineasenapine transdermal and hydroxyzine both increase sedation. Use Caution/Monitor.iloperidoneasenapine transdermal and iloperidone both increase sedation. Use Caution/Monitor.imipramineasenapine transdermal and imipramine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and imipramine both increase sedation. Use Caution/Monitor.indacaterol, inhaledasenapine transdermal and indacaterol, inhaled both increase QTc interval. Use Caution/Monitor.indapamideasenapine transdermal and indapamide both increase QTc interval. Use Caution/Monitor.isofluraneasenapine transdermal and isoflurane both increase sedation. Use Caution/Monitor.isradipineasenapine transdermal and isradipine both increase QTc interval. Use Caution/Monitor.ketamineasenapine transdermal and ketamine both increase sedation. Use Caution/Monitor.ketotifen, drug-eluting contact lensasenapine transdermal and ketotifen, drug-eluting contact lens both increase sedation. Use Caution/Monitor.lamotrigineasenapine transdermal and lamotrigine both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, asenapine transdermal. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantlemborexant, asenapine transdermal. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lenvatinibasenapine transdermal and lenvatinib both increase QTc interval. Use Caution/Monitor.levetiracetamasenapine transdermal and levetiracetam both increase sedation. Use Caution/Monitor.levocetirizineasenapine transdermal and levocetirizine both increase sedation. Use Caution/Monitor.levorphanolasenapine transdermal and levorphanol both increase sedation. Use Caution/Monitor.lofexidineasenapine transdermal and lofexidine both increase QTc interval. Use Caution/Monitor.loratadineasenapine transdermal and loratadine both increase sedation. Use Caution/Monitor.lorazepamasenapine transdermal and lorazepam both increase sedation. Use Caution/Monitor.loxapineasenapine transdermal and loxapine both increase sedation. Use Caution/Monitor.lumateperoneasenapine transdermal and lumateperone both increase sedation. Use Caution/Monitor.lurasidoneasenapine transdermal and lurasidone both increase sedation. Use Caution/Monitor.maprotilineasenapine transdermal and maprotiline both increase sedation. Use Caution/Monitor.meclizineasenapine transdermal and meclizine both increase sedation. Use Caution/Monitor.meperidineasenapine transdermal and meperidine both increase sedation. Use Caution/Monitor.meprobamateasenapine transdermal and meprobamate both increase sedation. Use Caution/Monitor.metaxaloneasenapine transdermal and metaxalone both increase sedation. Use Caution/Monitor.methadoneasenapine transdermal and methadone both increase sedation. Use Caution/Monitor.methocarbamolasenapine transdermal and methocarbamol both increase sedation. Use Caution/Monitor.methohexitalasenapine transdermal and methohexital both increase sedation. Use Caution/Monitor.methsuximideasenapine transdermal and methsuximide both increase sedation. Use Caution/Monitor.midazolamasenapine transdermal and midazolam both increase sedation. Use Caution/Monitor.mirtazapineasenapine transdermal and mirtazapine both increase sedation. Use Caution/Monitor.molindoneasenapine transdermal and molindone both increase sedation. Use Caution/Monitor.nalbuphineasenapine transdermal and nalbuphine both increase sedation. Use Caution/Monitor.nitrous oxideasenapine transdermal and nitrous oxide both increase sedation. Use Caution/Monitor.nortriptylineasenapine transdermal and nortriptyline both increase QTc interval. Use Caution/Monitor.asenapine transdermal and nortriptyline both increase sedation. Use Caution/Monitor.olanzapineasenapine transdermal and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instancesasenapine transdermal and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, asenapine transdermal. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.asenapine transdermal and oliceridine both increase sedation. Use Caution/Monitor.olodaterol inhaledasenapine transdermal and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmiasopicaponeasenapine transdermal and opicapone both increase sedation. Use Caution/Monitor.opium tinctureasenapine transdermal and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineasenapine transdermal and orphenadrine both increase sedation. Use Caution/Monitor.osilodrostatasenapine transdermal and osilodrostat both increase QTc interval. Use Caution/Monitor. Dose dependent QT prolongation - avoid drugs known to prolong the QT intervalosimertinibasenapine transdermal and osimertinib both increase QTc interval. Use Caution/Monitor.oxazepamasenapine transdermal and oxazepam both increase sedation. Use Caution/Monitor.ozanimodasenapine transdermal and ozanimod both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidoneasenapine transdermal and paliperidone both increase sedation. Use Caution/Monitor.pasireotideasenapine transdermal and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.pentazocineasenapine transdermal and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalasenapine transdermal and pentobarbital both increase sedation. Use Caution/Monitor.perampanelasenapine transdermal and perampanel both increase sedation. Use Caution/Monitor.perphenazineasenapine transdermal and perphenazine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and perphenazine both increase sedation. Use Caution/Monitor.pheniramineasenapine transdermal and pheniramine both increase sedation. Use Caution/Monitor.phenobarbitalasenapine transdermal and phenobarbital both increase sedation. Use Caution/Monitor.pimozideasenapine transdermal and pimozide both increase sedation. Use Caution/Monitor.pomalidomideasenapine transdermal and pomalidomide both increase sedation. Use Caution/Monitor.pregabalinasenapine transdermal and pregabalin both increase sedation. Use Caution/Monitor.primidoneasenapine transdermal and primidone