AdultPediatricGeriatricDosage Forms & Strengths transdermal system 3.8mg/24hr 5.7mg/24hr 7.6mg/24hrSchizophrenia Atypical antipsychotic indicated for adults with schizophrenia Apply 3.8 mg/24 hr patch initially; may increase dosage to 5.7 mg/24 hr or 7.6 mg/24 hr after 1 week Dosage Modifications Renal impairment Mild-to-severe (GFR 15-90 mL/min): No dosage adjustment necessary Patients on dialysis: Not studied Effect of renal function on the excretion of other metabolites has not been studied Hepatic impairment Mild-to-moderate (Child-Pugh A or B): No dosage adjustment necessary Severe (Child-Pugh C): Contraindicated Dosing Considerations In a short-term, placebo-controlled trial, no suggestion of added benefit was found at a dosage of 7.6 mg/24 hr; there was an increase in certain adverse reactions Safety of doses >7.6 mg/24 hr has not been evaluated in clinical studies Based on AUC of asenapine, asenapine transdermal 3.8 mg/24 hr corresponds to 5 mg PO BID of sublingual (SL) asenapine and asenapine transdermal 7.6 mg/24 hr corresponds to 10 mg PO BID of SL asenapine Safety and efficacy not establishedSchizophrenia Based on a pharmacokinetic study in elderly patients with asenapine SL, dosage adjustments are not recommended based on age alone Exposure in elderly patients is 30-40% higher as compared with adults Not indicated for dementia-related psychosis May increase risk of mortality in elderly patients with dementia-related psychosisInteraction CheckerEnter a drug name and asenapine transdermalNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (3)dronedaroneasenapine transdermal and dronedarone both increase QTc interval. Contraindicated.thalidomideasenapine transdermal and thalidomide both increase sedation. Contraindicated.thioridazineasenapine transdermal and thioridazine both increase QTc interval. Contraindicated.Serious - Use Alternative (140)alfentanilasenapine transdermal and alfentanil both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatealfuzosinasenapine transdermal and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug.amiodaroneasenapine transdermal and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideasenapine transdermal and amisulpride both increase QTc interval. Avoid or Use Alternate Drug.anagrelideasenapine transdermal and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.apomorphineasenapine transdermal and apomorphine both increase QTc interval. Avoid or Use Alternate Drug.aripiprazoleasenapine transdermal and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxideasenapine transdermal and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherasenapine transdermal and artemether both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineasenapine transdermal and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.atomoxetineasenapine transdermal and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenasenapine transdermal and benzhydrocodone/acetaminophen both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphineasenapine transdermal and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermal and buprenorphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine buccalasenapine transdermal and buprenorphine buccal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine subdermal implantasenapine transdermal and buprenorphine subdermal implant both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalasenapine transdermal and buprenorphine transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionasenapine transdermal and buprenorphine, long-acting injection both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequateceritinibasenapine transdermal and ceritinib both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazineasenapine transdermal and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinasenapine transdermal and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clozapineasenapine transdermal and clozapine both increase QTc interval. Avoid or Use Alternate Drug.codeineasenapine transdermal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatedasatinibasenapine transdermal and dasatinib both increase QTc interval. Avoid or Use Alternate Drug.degarelixasenapine transdermal and degarelix both increase QTc interval. Avoid or Use Alternate Drug.desfluraneasenapine transdermal and desflurane both increase QTc interval. Avoid or Use Alternate Drug.disopyramideasenapine transdermal and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dofetilideasenapine transdermal and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetronasenapine transdermal and dolasetron both increase QTc interval. Avoid or Use Alternate Drug.donepezilasenapine transdermal and donepezil both increase QTc interval. Avoid or Use Alternate Drug.droperidolasenapine transdermal and droperidol both increase QTc interval. Avoid or Use Alternate Drug.efavirenzasenapine transdermal and efavirenz both increase QTc interval. Avoid or Use Alternate Drug.eliglustatasenapine transdermal and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.encorafenibasenapine transdermal and encorafenib both increase QTc interval. Avoid or Use Alternate Drug.entrectinibasenapine transdermal and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.eribulinasenapine transdermal and eribulin both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseasenapine transdermal and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateasenapine transdermal and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateasenapine transdermal and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateasenapine transdermal and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramasenapine transdermal and escitalopram both increase QTc interval. Avoid or Use Alternate Drug.fentanylasenapine transdermal and fentanyl both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl intranasalasenapine transdermal and fentanyl intranasal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl iontophoretic transdermal systemasenapine transdermal and fentanyl iontophoretic transdermal system both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl transdermalasenapine transdermal and fentanyl transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefentanyl transmucosalasenapine transdermal and fentanyl transmucosal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatefexinidazolefexinidazole and asenapine transdermal both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval. fingolimodasenapine transdermal and fingolimod both increase QTc interval. Avoid or Use Alternate Drug.flecainideasenapine transdermal and flecainide both increase QTc interval. Avoid or Use Alternate Drug.fluconazoleasenapine transdermal and fluconazole both increase QTc interval. Contraindicated.fluvoxamineasenapine transdermal and fluvoxamine both increase QTc interval. Avoid or Use Alternate Drug.foscarnetasenapine transdermal and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.gemifloxacinasenapine transdermal and gemifloxacin both increase QTc interval. Avoid or Use Alternate Drug.gilteritinibasenapine transdermal and gilteritinib both increase QTc interval. Avoid or Use Alternate Drug.glasdegibasenapine transdermal and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.goserelinasenapine transdermal and goserelin both increase QTc interval. Avoid or Use Alternate Drug.granisetronasenapine transdermal and granisetron both increase QTc interval. Avoid or Use Alternate Drug.histrelinasenapine transdermal and histrelin both increase QTc interval. Avoid or Use Alternate Drug.hydrocodoneasenapine transdermal and hydrocodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatehydromorphoneasenapine transdermal and hydromorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatehydroxychloroquine sulfateasenapine transdermal and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzineasenapine transdermal and hydroxyzine both increase QTc interval. Avoid or Use Alternate Drug.ibutilideasenapine transdermal and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.iloperidoneasenapine transdermal and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabasenapine transdermal and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.isofluraneasenapine transdermal and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.itraconazoleasenapine transdermal and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibasenapine transdermal and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.lapatinibasenapine transdermal and lapatinib both increase QTc interval. Avoid or Use Alternate Drug.lefamulinasenapine transdermal and lefamulin both increase QTc interval. Avoid or Use Alternate Drug.leuprolideasenapine transdermal and leuprolide both increase QTc interval. Avoid or Use Alternate Drug.levodopa inhaledasenapine transdermal decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Atypical (2nd generation) antipsychotics inhibit dopamine D2 receptors in varying degrees (clozapine and quetiapine are lower risk). .levofloxacinasenapine transdermal and levofloxacin both increase QTc interval. Avoid or Use Alternate Drug.lithiumasenapine transdermal and lithium both increase QTc interval. Avoid or Use Alternate Drug.loperamideasenapine transdermal and loperamide both increase QTc interval. Avoid or Use Alternate Drug.lopinavirasenapine transdermal and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.macimorelinasenapine transdermal and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.maprotilineasenapine transdermal and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.mefloquineasenapine transdermal and mefloquine both increase QTc interval. Avoid or Use Alternate Drug.methadoneasenapine transdermal and methadone both increase QTc interval. Avoid or Use Alternate Drug.metoclopramide intranasalasenapine transdermal increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.midostaurinasenapine transdermal and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mifepristoneasenapine transdermal and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.mirtazapineasenapine transdermal and mirtazapine both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibmobocertinib and asenapine transdermal both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.morphineasenapine transdermal and morphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatemoxifloxacinasenapine transdermal and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotinibasenapine transdermal and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.octreotideasenapine transdermal and octreotide both increase QTc interval. Avoid or Use Alternate Drug.ofloxacinasenapine transdermal and ofloxacin both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasalasenapine transdermal and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronasenapine transdermal and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.oxaliplatinasenapine transdermal and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.oxycodoneasenapine transdermal and oxycodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequateoxymorphoneasenapine transdermal and oxymorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatepaliperidoneasenapine transdermal and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.panobinostatasenapine transdermal and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.paroxetineasenapine transdermal and paroxetine both increase QTc interval. Avoid or Use Alternate Drug.pazopanibasenapine transdermal and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.pentamidineasenapine transdermal and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.pimavanserinasenapine transdermal and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.pimozideasenapine transdermal and pimozide both increase QTc interval. Contraindicated.pitolisantasenapine transdermal and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodasenapine transdermal and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.posaconazoleasenapine transdermal and posaconazole both increase QTc interval. Contraindicated.primaquineasenapine transdermal and primaquine both increase QTc interval. Avoid or Use Alternate Drug.procainamideasenapine transdermal and procainamide both increase QTc interval. Avoid or Use Alternate Drug.promethazineasenapine transdermal and promethazine both decrease QTc interval. Avoid or Use Alternate Drug.propafenoneasenapine transdermal and propafenone both increase QTc interval. Avoid or Use Alternate Drug.quinidineasenapine transdermal and quinidine both increase QTc interval. Avoid or Use Alternate Drug.quinineasenapine transdermal and quinine both increase QTc interval. Avoid or Use Alternate Drug.ranolazineasenapine transdermal and ranolazine both increase QTc interval. Avoid or Use Alternate Drug.ribociclibasenapine transdermal and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.risperidoneasenapine transdermal and risperidone both increase QTc interval. Avoid or Use Alternate Drug.romidepsinasenapine transdermal and romidepsin both increase QTc interval. Avoid or Use Alternate Drug.saquinavirasenapine transdermal and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.selinexorselinexor, asenapine transdermal. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sertralineasenapine transdermal and sertraline both increase QTc interval. Avoid or Use Alternate Drug.sevofluraneasenapine transdermal and sevoflurane both increase QTc interval. Avoid or Use Alternate Drug.siponimodasenapine