both increase sedation. Use Caution/Monitor.deutetrabenazineflurazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and flurazepam both increase sedation. Use Caution/Monitor.dexfenfluramineflurazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineflurazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateflurazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineflurazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideflurazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineflurazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiazepam and flurazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, flurazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionflurazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and flurazepam both increase sedation. Use Caution/Monitor.difenoxin hclflurazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and flurazepam both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and flurazepam both increase sedation. Use Caution/Monitor.diphenoxylate hclflurazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneflurazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineflurazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineflurazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineflurazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinflurazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinflurazepam and doxepin both increase sedation. Use Caution/Monitor.doxylamineflurazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidolflurazepam and droperidol both increase sedation. Use Caution/Monitor.duvelisibduvelisib will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate.efavirenzefavirenz will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.elagolixelagolix decreases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.encorafenibencorafenib, flurazepam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.ephedrineflurazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineflurazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicflurazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, flurazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and flurazepam both increase sedation. Use Caution/Monitor.ethanolflurazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and flurazepam both increase sedation. Use Caution/Monitor.etravirineetravirine will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fedratinibfedratinib will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.fenfluramineflurazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinflurazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineflurazepam and fluphenazine both increase sedation. Use Caution/Monitor.formoterolflurazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosamprenavirfosamprenavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.fosphenytoinfosphenytoin will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.gabapentingabapentin, flurazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, flurazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneflurazepam and ganaxolone both increase sedation. Use Caution/Monitor.haloperidolflurazepam and haloperidol both increase sedation. Use Caution/Monitor.hydromorphoneflurazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and flurazepam both increase sedation. Use Caution/Monitor.iloperidoneflurazepam and iloperidone both increase sedation. Use Caution/Monitor.iloperidone increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imipramineflurazepam and imipramine both increase sedation. Use Caution/Monitor.indinavirindinavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.isoproterenolflurazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineistradefylline will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleitraconazole will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketamineketamine and flurazepam both increase sedation. Use Caution/Monitor.ketoconazoleketoconazole will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketotifen, ophthalmicflurazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, flurazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lenacapavirlenacapavir will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates.letermovirletermovir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterolflurazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levoketoconazolelevoketoconazole will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levorphanolflurazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineflurazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineflurazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineflurazepam and lofexidine both increase sedation. Use Caution/Monitor.lopinavirlopinavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.loprazolamflurazepam and loprazolam both increase sedation. Use Caution/Monitor.lorazepamflurazepam and lorazepam both increase sedation. Use Caution/Monitor.lorlatiniblorlatinib will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.lormetazepamflurazepam and lormetazepam both increase sedation. Use Caution/Monitor.loxapineflurazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledflurazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, flurazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineflurazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaflurazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninflurazepam and melatonin both increase sedation. Use Caution/Monitor.meperidineflurazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamateflurazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolflurazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneflurazepam and metaxalone both increase sedation. Use Caution/Monitor.methadoneflurazepam and methadone both increase sedation. Use Caution/Monitor.methamphetamineflurazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolflurazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineflurazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolamflurazepam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, flurazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineflurazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineflurazepam and mirtazapine both increase sedation. Use Caution/Monitor.mitotanemitotane decreases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilflurazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineflurazepam and morphine both increase sedation. Use Caution/Monitor.motherwortflurazepam and motherwort both increase sedation. Use Caution/Monitor.moxonidineflurazepam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneflurazepam and nabilone both increase sedation. Use Caution/Monitor.nafcillinnafcillin will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nalbuphineflurazepam and nalbuphine both increase sedation. Use Caution/Monitor.nefazodonenefazodone will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nelfinavirnelfinavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.norepinephrineflurazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineflurazepam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapineflurazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, flurazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tinctureflurazepam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineflurazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamflurazepam and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneflurazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneflurazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneflurazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumflurazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverineflurazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocineflurazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and flurazepam both increase sedation. Use Caution/Monitor.perphenazineflurazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineflurazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and flurazepam both increase sedation. Use Caution/Monitor.phentermineflurazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineflurazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POflurazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinphenytoin will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pholcodineflurazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozideflurazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolflurazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleposaconazole will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pregabalinpregabalin, flurazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and flurazepam both increase sedation. Use Caution/Monitor.prochlorperazineflurazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and flurazepam both increase sedation. Use Caution/Monitor.propofolpropofol and flurazepam both increase sedation. Use Caution/Monitor.propylhexedrineflurazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineflurazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamflurazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapineflurazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonflurazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, flurazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibribociclib will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinrifabutin will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifampinrifampin will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.risperidoneflurazepam and risperidone both increase sedation. Use Caution/Monitor.ritonavirritonavir increases levels of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.rucaparibrucaparib will increase the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.salmeterolflurazepam increases and salmeterol decreases sedation. Effect of interaction is not