AdultPediatricGeriatricDosage Forms & Strengths tablet 10mg 25mg 50mg 100mg Schizophrenia Initial 50-100 mg PO q8hr, THEN 200-800 mg/day PO divided q6-12hr Depressive Disorders 25 mg PO q8hr; may titrate to effect (20-200 mg/day) Renal Impairment Dose adjustment not necessary in dialysis Hepatic Disease Initiate treatment at lower dose and titrate to effect (monitor) Other Indications & Uses Psychotic disorders, geriatric psychoneurotic manifestations, pediatric behavioral disordersDosage Forms & Strengths tablet 10mg 25mg 50mg 100mg Schizophrenia <2 years: Safety and efficacy not established 2-12 years: 0.5-3 mg/kg/day divided q8hr PO, no more than 3 mg/kg/day >12 years: Initial 50-100 mg PO q8hr; titrate to 200-800 mg/day PO divided q6-12hr Potential toxic dose <6 years old: 3 mg/kgInitiate treatment at lower dose and titrate to effect (monitor) Schizophrenia Initial 50-100 mg PO q8hr, THEN 200-800 mg/day PO divided q6-12hr Debilitated patients: Initiate treatment at lower dose Depressive disorders 25 mg PO q8hr; may titrate to effect (20-200 mg/day)Interaction CheckerEnter a drug name and thioridazineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (69)albuterolalbuterol and thioridazine both increase QTc interval. Contraindicated.alfuzosinalfuzosin and thioridazine both increase QTc interval. Contraindicated.amiodaronethioridazine and amiodarone both increase QTc interval. Contraindicated.amisulprideamisulpride and thioridazine both increase QTc interval. Contraindicated.amisulpride, thioridazine. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndrome.anagrelideanagrelide and thioridazine both increase QTc interval. Contraindicated.apomorphineapomorphine and thioridazine both increase QTc interval. Contraindicated.arformoterolarformoterol and thioridazine both increase QTc interval. Contraindicated.aripiprazolearipiprazole and thioridazine both increase QTc interval. Contraindicated.artemetherartemether and thioridazine both increase QTc interval. Contraindicated.asenapineasenapine and thioridazine both increase QTc interval. Contraindicated.asenapine transdermalasenapine transdermal and thioridazine both increase QTc interval. Contraindicated.atomoxetineatomoxetine and thioridazine both increase QTc interval. Contraindicated.buprenorphinebuprenorphine and thioridazine both increase QTc interval. Contraindicated.buprenorphine buccalbuprenorphine buccal and thioridazine both increase QTc interval. Contraindicated.buprenorphine subdermal implantbuprenorphine subdermal implant and thioridazine both increase QTc interval. Contraindicated.buprenorphine transdermalbuprenorphine transdermal and thioridazine both increase QTc interval. Contraindicated.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and thioridazine both increase QTc interval. Contraindicated.ceritinibceritinib and thioridazine both increase QTc interval. Contraindicated.clomipraminethioridazine will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.clozapineclozapine and thioridazine both increase QTc interval. Contraindicated.crizotinibcrizotinib and thioridazine both increase QTc interval. Contraindicated. Thioridazine is contraindicated with drugs that may prolong the QT interval.degarelixdegarelix and thioridazine both increase QTc interval. Contraindicated.desipraminethioridazine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.disopyramidethioridazine and disopyramide both increase QTc interval. Contraindicated.dofetilidedofetilide increases toxicity of thioridazine by QTc interval. Contraindicated.donepezildonepezil and thioridazine both increase QTc interval. Contraindicated.doxepinthioridazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.eliglustatthioridazine increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given concomitantly with strong or moderate CYP3A inhibitors.eliglustat and thioridazine both increase QTc interval. Contraindicated.escitalopramescitalopram increases toxicity of thioridazine by QTc interval. Contraindicated.fezolinetantthioridazine will increase the level or effect of fezolinetant by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Fezolinetant AUC and peak plasma concentration are increased if coadministered with drugs that are weak, moderate, or strong CYP1A2 inhibitorsfingolimodfingolimod and thioridazine both increase QTc interval. Contraindicated.fluoxetinethioridazine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.thioridazine and fluoxetine both increase QTc interval. Contraindicated.fluoxetine increases levels of thioridazine by decreasing metabolism. Contraindicated. Risk of long QT syndrome.gemifloxacingemifloxacin and thioridazine both increase QTc interval. Contraindicated.gilteritinibgilteritinib and thioridazine both increase QTc interval. Contraindicated.goserelingoserelin increases toxicity of thioridazine by QTc interval. Contraindicated. Increases risk of torsades de pointes.granisetrongranisetron and thioridazine both increase QTc interval. Contraindicated.hydroxyzinehydroxyzine and thioridazine both increase QTc interval. Contraindicated.ibutilidethioridazine and ibutilide both increase QTc interval. Contraindicated.imipraminethioridazine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.indapamidethioridazine and indapamide both increase QTc interval. Contraindicated.isofluraneisoflurane and thioridazine both increase QTc interval. Contraindicated.leuprolideleuprolide increases toxicity of thioridazine by QTc interval. Contraindicated. Increases risk of torsades de pointes.lithiumlithium and thioridazine both increase QTc interval. Contraindicated.metrizamidethioridazine, metrizamide. Mechanism: unknown. Contraindicated. Risk of seizure. D/C phenothiazine 24h before admin. of metrizamide.mifepristonemifepristone, thioridazine. QTc interval. Contraindicated.mirtazapinemirtazapine and thioridazine both increase QTc interval. Contraindicated.nortriptylinethioridazine will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.olanzapineolanzapine and thioridazine both increase QTc interval. Contraindicated.oxaliplatinoxaliplatin and thioridazine both increase QTc interval. Contraindicated.paroxetineparoxetine increases levels of thioridazine by decreasing metabolism. Contraindicated. Risk of long QT syndrome.pasireotidethioridazine and pasireotide both increase QTc interval. Contraindicated.pentamidinethioridazine and pentamidine both increase QTc interval. Contraindicated.pimozidethioridazine and pimozide both increase QTc interval. Contraindicated.primaquineprimaquine and thioridazine both increase QTc interval. Contraindicated.procainamidethioridazine and procainamide both increase QTc interval. Contraindicated.quinidinethioridazine and quinidine both increase QTc interval. Contraindicated.quininethioridazine and quinine both increase QTc interval. Contraindicated.rolapitantrolapitant will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Rolapitant moderately inhibits CYP2D6. Coadministration with thioridazine, a CYP2D6 substrate, causes a significant increase in thioridazine plasma concentration that may result in QT prolongation and torsades de pointes.sertralinesertraline increases levels of thioridazine by decreasing metabolism. Contraindicated. Risk of long QT syndrome.sertraline and thioridazine both increase QTc interval. Contraindicated.sevofluranesevoflurane and thioridazine both increase QTc interval. Contraindicated.siponimodsiponimod and thioridazine both increase QTc interval. Contraindicated.solifenacinsolifenacin and thioridazine both increase QTc interval. Contraindicated.sorafenibsorafenib and thioridazine both increase QTc interval. Contraindicated.sotalolthioridazine and sotalol both increase QTc interval. Contraindicated.sunitinibsunitinib and thioridazine both increase QTc interval. Contraindicated.tacrolimustacrolimus and thioridazine both increase QTc interval. Contraindicated.tetrabenazinetetrabenazine and thioridazine both increase QTc interval. Contraindicated.toremifenethioridazine and toremifene both increase QTc interval. Contraindicated. Concurrent use of thioridazine with other agents that prolong QTc interval is contraindicated.vorinostatvorinostat and thioridazine both increase QTc interval. Contraindicated.Serious - Use Alternative (130)adagrasibadagrasib will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of adagrasib, a CYP2D6 inhibitor, with sensitive CYP2D6 substrates unless otherwise recommended in the prescribing information for these substrates.adagrasib, thioridazine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.aminolevulinic acid oralaminolevulinic acid oral, thioridazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.aminolevulinic acid topicalthioridazine increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid.amiodaroneamiodarone will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.amiodarone increases levels of thioridazine by decreasing metabolism. Contraindicated.amitriptylinethioridazine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amoxapinethioridazine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.apomorphinethioridazine decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.arsenic trioxidethioridazine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineartemether/lumefantrine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.thioridazine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapineasenapine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, thioridazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).benzhydrocodone/acetaminophen and thioridazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebremelanotidebremelanotide will decrease the level or effect of thioridazine by Other (see comment). Avoid or Use Alternate Drug. Bremelanotide may slow gastric emptying and potentially reduces the rate and extent of absorption of concomitantly administered oral medications. Avoid use when taking any oral drug that is dependent on threshold concentrations for efficacy. Interactions listed are representative examples and do not include all possible clinical examples.bromocriptinethioridazine decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and thioridazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalbuprenorphine transdermal and thioridazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionbuprenorphine, long-acting injection and thioridazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebupropionbupropion will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.cabergolinethioridazine decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.calcium/magnesium/potassium/sodium oxybatesthioridazine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carvedilolcarvedilol, thioridazine. Either increases levels of the other by decreasing metabolism. Contraindicated. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact).celecoxibcelecoxib will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.chloroquinechloroquine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.chlorpromazinechlorpromazine and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.cimetidinecimetidine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.citalopramthioridazine and citalopram both increase QTc interval. Avoid or Use Alternate Drug. Thioridazine should be avoided in combination with drugs that are known to prolong QTc interval.clarithromycinthioridazine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipraminethioridazine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. darifenacindarifenacin will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.desipraminethioridazine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.diphenhydraminediphenhydramine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.dofetilidethioridazine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dopaminethioridazine decreases effects of dopamine by pharmacodynamic antagonism. Contraindicated.dosulepinthioridazine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.doxepinthioridazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.dronedaronedronedarone will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.thioridazine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolthioridazine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineduloxetine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.thioridazine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated.encorafenibencorafenib and thioridazine both increase QTc interval. Avoid or Use Alternate Drug. Encorafenib is associated with dose-dependent QTc interval prolongation. Avoid with drugs known to prolong QT interval.entrectinibthioridazine and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.epinephrineepinephrine and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicepinephrine racemic and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.eribulineribulin and thioridazine both increase QTc interval. Avoid or Use Alternate Drug. Potential for enhanced QTc-prolonging effects; if concurrent use is necessary then ECG monitoring is recommended.erythromycin basethioridazine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatethioridazine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatethioridazine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatethioridazine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.fentanylfentanyl, thioridazine. Either increases effects