Use Caution/Monitor.ospemifeneibuprofen increases levels of ospemifene by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.ibuprofen, ospemifene. Either increases levels of the other by plasma protein binding competition. Modify Therapy/Monitor Closely.diphenhydramine, ospemifene. Either increases levels of the other by plasma protein binding competition. Modify Therapy/Monitor Closely.oxazepamdiphenhydramine and oxazepam both increase sedation. Use Caution/Monitor.panax ginsengibuprofen and panax ginseng both increase anticoagulation. Use Caution/Monitor.oxybutynindiphenhydramine and oxybutynin both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin topicaldiphenhydramine and oxybutynin topical both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin transdermaldiphenhydramine and oxybutynin transdermal both decrease cholinergic effects/transmission. Use Caution/Monitor.oxycodonediphenhydramine will increase the level or effect of oxycodone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.diphenhydramine and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonediphenhydramine will increase the level or effect of oxymorphone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.diphenhydramine and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonediphenhydramine and paliperidone both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of paliperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.paliperidone increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pancuroniumdiphenhydramine and pancuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.papaveretumdiphenhydramine and papaveretum both increase sedation. Use Caution/Monitor.papaverinediphenhydramine and papaverine both increase sedation. Use Caution/Monitor.parecoxibibuprofen and parecoxib both increase anticoagulation. Use Caution/Monitor.ibuprofen and parecoxib both increase serum potassium. Use Caution/Monitor.paroxetineparoxetine, ibuprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.passion flowerpassion flower increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.pau d'arcoibuprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.pegaspargasepegaspargase increases effects of ibuprofen by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of bleeding events.peginterferon alfa 2bpeginterferon alfa 2b decreases levels of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered.penbutololpenbutolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.pentazocinediphenhydramine and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitaldiphenhydramine and pentobarbital both increase sedation. Use Caution/Monitor.perampanelperampanel and diphenhydramine both increase sedation. Use Caution/Monitor.perindoprilperindopril, ibuprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.perphenazinediphenhydramine and perphenazine both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of perphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.perphenazine increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.phendimetrazinediphenhydramine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenelzinephenelzine increases effects of diphenhydramine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .phenindionephenindione and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.phenobarbitaldiphenhydramine and phenobarbital both increase sedation. Use Caution/Monitor.phenoxybenzamineibuprofen decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.phenterminediphenhydramine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phentolamineibuprofen decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.phenylephrinediphenhydramine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POdiphenhydramine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinediphenhydramine and pholcodine both increase sedation. Use Caution/Monitor.physostigminephysostigmine increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.phytoestrogensibuprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.pilocarpinepilocarpine increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozidediphenhydramine and pimozide both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pindololpindolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.pirbuterolibuprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenhydramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.piroxicamibuprofen and piroxicam both increase anticoagulation. Use Caution/Monitor.ibuprofen and piroxicam both increase serum potassium. Use Caution/Monitor.pralidoximediphenhydramine and pralidoxime both decrease cholinergic effects/transmission. Use Caution/Monitor.pivmecillinampivmecillinam, ibuprofen. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.pivmecillinam, ibuprofen. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.potassium acid phosphateibuprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.potassium chlorideibuprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.potassium citrateibuprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.potassium iodidepotassium iodide and ibuprofen both increase serum potassium. Use Caution/Monitor.pralatrexateibuprofen increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor. NSAIDs may delay pralatrexate clearance, increasing drug exposure. Adjust the pralatrexate dose as needed.prasugrelibuprofen, prasugrel. Either increases effects of the other by anticoagulation. Use Caution/Monitor. Chronic use of NSAIDs with prasugrel may increase bleeding risk.prazosinibuprofen decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.prednisoloneibuprofen, prednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.prednisoneibuprofen, prednisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.pregabalinpregabalin, diphenhydramine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidonediphenhydramine and primidone both increase sedation. Use Caution/Monitor.probenecidibuprofen will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.prochlorperazinediphenhydramine and prochlorperazine both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.promethazinediphenhydramine and promethazine both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of promethazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.promethazine increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.propafenonediphenhydramine will increase the level or effect of propafenone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.propanthelinediphenhydramine and propantheline both decrease cholinergic effects/transmission. Use Caution/Monitor.propofolpropofol and diphenhydramine both increase sedation. Use Caution/Monitor.propranololpropranolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.diphenhydramine will increase the level or effect of propranolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.propylhexedrinediphenhydramine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protamineprotamine and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.protriptylinediphenhydramine and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.diphenhydramine and protriptyline both increase sedation. Use Caution/Monitor.pyridostigminepyridostigmine increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.quazepamdiphenhydramine and quazepam both increase sedation. Use Caution/Monitor.quetiapinediphenhydramine and quetiapine both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of quetiapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.quetiapine increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.quinaprilquinapril, ibuprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ramelteondiphenhydramine and ramelteon both increase sedation. Use Caution/Monitor.ramiprilramipril, ibuprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.rapacuroniumdiphenhydramine and rapacuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.reishiibuprofen and reishi both increase anticoagulation. Use Caution/Monitor.reteplaseibuprofen and reteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.risperidonediphenhydramine and risperidone both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of risperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of risperidone by pharmacodynamic antagonism. Use Caution/Monitor.risperidone increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.rivaroxabanrivaroxaban, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: NSAIDs are known to increase bleeding. Bleeding risk may be increased when NSAIDs are used concomitantly with rivaroxaban. Monitor for signs/symptoms of blood loss.rivastigminerivastigmine increases toxicity of ibuprofen by pharmacodynamic synergism. Use Caution/Monitor. Monitor patients for symptoms of active or occult gastrointestinal bleeding.rocuroniumdiphenhydramine and rocuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.sacubitril/valsartansacubitril/valsartan and ibuprofen both increase serum potassium. Use Caution/Monitor.sacubitril/valsartan, ibuprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ibuprofen decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.salicylates (non-asa)ibuprofen and salicylates (non-asa) both increase anticoagulation. Use Caution/Monitor.ibuprofen and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.salmeteroldiphenhydramine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.salsalateibuprofen and salsalate both increase anticoagulation. Use Caution/Monitor.ibuprofen and salsalate both increase serum potassium. Use Caution/Monitor.scopolaminediphenhydramine and scopolamine both decrease cholinergic effects/transmission. Use Caution/Monitor.saw palmettosaw palmetto increases toxicity of ibuprofen by unspecified interaction mechanism. Use Caution/Monitor. May increase risk of bleeding.scullcapdiphenhydramine and scullcap both increase sedation. Use Caution/Monitor.secobarbitaldiphenhydramine and secobarbital both increase sedation. Use Caution/Monitor.sertralinesertraline, ibuprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.Siberian ginsengibuprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.sevofluranesevoflurane and diphenhydramine both increase sedation. Use Caution/Monitor.shepherd's pursediphenhydramine and shepherd's purse both increase sedation. Use Caution/Monitor.silodosinibuprofen decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.sodium picosulfate/magnesium oxide/anhydrous citric acidibuprofen, sodium picosulfate/magnesium oxide/anhydrous citric acid. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May be associated with fluid and electrolyte imbalances.sodium sulfate/?magnesium sulfate/potassium chloridesodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of ibuprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycolibuprofen, sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol. Other (see comment). Use Caution/Monitor. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance.sodium sulfate/potassium sulfate/magnesium sulfatesodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of ibuprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.solifenacindiphenhydramine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.sotalolsotalol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.sparsentanibuprofen and sparsentan both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Coadministration of NSAIDS, including selective COX-2 inhibitors, may result in deterioration of kidney function (eg, possible kidney failure). Monitor for signs of worsening renal function with concomitant use with NSAIDs. spironolactonespironolactone and ibuprofen both increase serum potassium. Modify Therapy/Monitor Closely.stiripentolstiripentol, diphenhydramine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.succinylcholineibuprofen and succinylcholine both increase serum potassium. Use Caution/Monitor.succinylcholine increases and diphenhydramine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.sufentanildiphenhydramine and sufentanil both increase sedation. Use Caution/Monitor.sulfasalazineibuprofen and sulfasalazine both increase anticoagulation. Use Caution/Monitor.ibuprofen and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulindacibuprofen and sulindac both increase anticoagulation. Use Caution/Monitor.ibuprofen and sulindac both increase serum potassium. Use Caution/Monitor.tafluprosttafluprost, ibuprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).tamoxifendiphenhydramine decreases effects of tamoxifen by decreasing metabolism. Use Caution/Monitor. Inhibition of CYP2D6