AdultPediatricMajor Depressive Disorder Pending FDA approval for adjunctive treatment of major depressive disorder in patients with inadequate response to standard therapiesSafety and efficacy not established Mechanism of Action Buprenorphine: Partial mu-opioid receptor agonist and kappa-opioid receptor antagonist Samidorphan: Mu-opioid antagonist No images available for this drug. No images available for this drug.A Patient Handout is not currently available for this monograph.Print