of the recommended dose (ie, decrease dose by 75%) Strong CYP2D6 or CYP3A4 inhibitors: Administer half of recommended dose Strong CYP2D6 AND CYP3A4 inhibitors: Administer a quarter of the recommended dose (ie, decrease dose by 75%) Strong CYP3A4 inducers: double recommended dose over 1-2 weeks Interaction CheckerEnter a drug name and aripiprazoleNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (4)amisulprideamisulpride, aripiprazole. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndrome.cisapridearipiprazole and cisapride both increase QTc interval. Contraindicated.dronedaronearipiprazole and dronedarone both increase QTc interval. Contraindicated.thioridazinearipiprazole and thioridazine both increase QTc interval. Contraindicated.Serious - Use Alternative (127)abametapirabametapir will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.amiodaronearipiprazole and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulpridearipiprazole and amisulpride both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.apalutamideapalutamide will decrease the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphinearipiprazole decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.arsenic trioxidearipiprazole and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinearipiprazole and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapinearipiprazole and asenapine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.azithromycinaripiprazole and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.bedaquilinearipiprazole and bedaquiline both increase QTc interval. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, aripiprazole. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.bromocriptinearipiprazole decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.buprenorphinearipiprazole and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalbuprenorphine transdermal and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.cabergolinearipiprazole decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.calcium/magnesium/potassium/sodium oxybatesaripiprazole, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carbamazepinecarbamazepine will decrease the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If carbamazepine is started in a patient already taking aripiprazole, the aripiprazole dose should be doubled; reduce aripiprazole dose if carbamazepine is discontinuedceritinibceritinib will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chloramphenicolchloramphenicol will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chloroquinechloroquine will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.aripiprazole and chloroquine both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazinearipiprazole and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.cimetidinecimetidine will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.citalopramaripiprazole and citalopram both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinclarithromycin will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.aripiprazole and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clozapinearipiprazole and clozapine both increase QTc interval. Avoid or Use Alternate Drug.crizotinibaripiprazole and crizotinib both increase QTc interval. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. desfluranedesflurane and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.disopyramidearipiprazole and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dofetilidearipiprazole and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dopaminearipiprazole decreases effects of dopamine by pharmacodynamic antagonism. Contraindicated.droperidolaripiprazole and droperidol both increase QTc interval. Avoid or Use Alternate Drug.eliglustataripiprazole and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.eliglustat and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.encorafenibaripiprazole and encorafenib both increase QTc interval. Avoid or Use Alternate Drug.entrectinibaripiprazole and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.enzalutamideenzalutamide will decrease the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.eribulinaripiprazole and eribulin both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseerythromycin base will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.aripiprazole and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateerythromycin ethylsuccinate will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.aripiprazole and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateerythromycin lactobionate will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.erythromycin stearateerythromycin stearate will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.fexinidazolefexinidazole and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.flecainidearipiprazole and flecainide both increase QTc interval. Avoid or Use Alternate Drug.fluconazolearipiprazole and fluconazole both increase QTc interval. Contraindicated.fluoxetinefluoxetine will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.aripiprazole and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.fluphenazinearipiprazole and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.foscarnetaripiprazole and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.glasdegibaripiprazole and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.hydrocodonehydrocodone, aripiprazole. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydroxychloroquine sulfatearipiprazole and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.ibutilidearipiprazole and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.idelalisibidelalisib will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substratesiloperidonearipiprazole and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabaripiprazole and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.isofluranearipiprazole and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.itraconazolearipiprazole and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib will decrease the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.aripiprazole and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.lefamulinlefamulin and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.lenvatinibaripiprazole and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.levodopaaripiprazole decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug.levodopa inhaledaripiprazole decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Atypical (2nd generation) antipsychotics inhibit dopamine D2 receptors in varying degrees (clozapine and quetiapine are lower risk). .lisuridearipiprazole decreases effects of lisuride by pharmacodynamic antagonism. Contraindicated.lonafarniblonafarnib will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.lopinavirlopinavir will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.aripiprazole and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.maprotilinearipiprazole and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.mefloquinemefloquine increases toxicity of aripiprazole by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.methadonearipiprazole and methadone both increase QTc interval. Avoid or Use Alternate Drug.methyldopaaripiprazole decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.metoclopramide intranasalaripiprazole, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.aripiprazole increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.midostaurinaripiprazole and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mifepristonearipiprazole and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.moxifloxacinaripiprazole and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nefazodonenefazodone will increase the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.nilotinibaripiprazole and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasalaripiprazole and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronaripiprazole and ondansetron both increase QTc interval. Avoid or Use Alternate Drug.osimertinibaripiprazole and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.oxaliplatinaripiprazole and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.ozanimodaripiprazole and ozanimod both increase QTc interval. Avoid or Use Alternate Drug.paliperidonearipiprazole and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.panobinostataripiprazole and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.paroxetineparoxetine will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.pazopanibaripiprazole and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.pentamidinearipiprazole and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.perphenazinearipiprazole and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.pimavanserinaripiprazole and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.pimozidearipiprazole and pimozide both increase QTc interval. Contraindicated.pitolisantaripiprazole and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodaripiprazole and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.posaconazolearipiprazole and posaconazole both increase QTc interval. Contraindicated.pramipexolearipiprazole decreases effects of pramipexole by pharmacodynamic antagonism. Contraindicated.procainamidearipiprazole and procainamide both increase QTc interval. Avoid or Use Alternate Drug.propafenonearipiprazole and propafenone both increase QTc interval. Avoid or Use Alternate Drug.quetiapinearipiprazole and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.quinidinearipiprazole and quinidine both increase QTc interval. Contraindicated.quininearipiprazole and quinine both increase QTc interval. Avoid or Use Alternate Drug.ranolazinearipiprazole and ranolazine both increase QTc interval. Avoid or Use Alternate Drug.ribociclibaripiprazole and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.rifabutinrifabutin will decrease the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifampinrifampin will decrease the level or effect of aripiprazole by affecting hepatic/intestinal enzyme CYP3A4