AdultPediatricDosage Forms & Strengths aerosol metered-dose inhaler 90mcg (base)/actuation (equivalent to 108mcg albuterol sulfate) powder metered-dose inhaler 90mcg (base)/actuation (equivalent to 108mcg albuterol sulfate); ProAir RespiClick powder metered-dose inhaler with electronic module 90mcg (base)/actuation (equivalent to 108mcg albuterol sulfate); ProAir Digihaler tablet 2mg 4mg tablet, extended release 4mg 8mg nebulizer solution 1.25mg/3mL (contains 1.50 mg albuterol sulfate/3 mL) 0.63mg/3mL (contains 0.75 mg albuterol sulfate/3 mL) syrup 2mg/5mL Bronchospasm Indicated for treatment or prevention of bronchospasm in patients with reversible obstructive airway disease Nebulizer solution: 2.5 mg BID/TID PRN; 1.25 - 5 mg q4-8hr PRN for quick relief Aerosol metered-dose inhaler: 180 mcg (2 puffs) inhaled PO q4-6hr; not to exceed 12 inhalations/24 hr Powder metered-dose inhaler (ProAir RespiClick or ProAir Digihaler): 180 mcg (2 puffs) inhaled PO q4-6hr; not to exceed 12 inhalations/24 hr; in some patients 1 inhalation (90 mcg) q4hr may be sufficient Tablet and syrup: 2-4 mg PO q6-8hr; not to exceed 32 mg/day Extended-release tablets: 8 mg PO q12hr; in some patients 4 mg PO q12hr sufficient; not to exceed 32 mg/day Acute or Severe Bronchospasm Nebulizer solution: 2.5-5 mg q20min for 3 doses; follow with 2.5-10 mg q1-4hr PRN or 10-15 min by continuous nebulization Metered-dose inhaler: 4-8 puffs inhaled q20min for up to 4 hr and then q1-4hr PRN Exercise-induced Bronchospasm Indicated for prevention of exercise-induced bronchospasm Aerosol or powder metered-dose inhaler: 180 mcg (2 puffs) inhaled 15-30 min before exercise Spinal Cord Injury (Orphan) Prevention of paralysis caused by spinal cord injury Orphan indication sponsor MotoGen, Inc, 3 Pine View Road, Mount Kisco, NY 10549 Dosing Considerations ProAir Digihaler: Contains a QR code and a built-in electronic module which automatically detects, records, and stores data on inhaler events, including peak inspiratory flow rate (L/min)Dosage Forms & Strengths aerosol metered-dose inhaler 90mcg (base)/actuation (equivalent to 108mcg albuterol sulfate) powder metered-dose inhaler 90mcg (base)/actuation (equivalent to 108mcg abluterol sulfate); ProAir RespiClick powder metered-dose inhaler with electronic module 90mcg (base)/actuation (equivalent to 108mcg albuterol sulfate); ProAir Digihaler tablet 2mg 4mg tablet, extended-release 4mg 8mg nebulizer solution 1.25mg/3mL (contains 1.50 mg albuterol sulfate/3 mL) 0.63mg/3mL (contains 0.75 mg albuterol sulfate/3 mL) syrup 2mg/5mL Bronchospasm Treatment and prevention of bronchospasm associated with obstructive airway disease Aerosol metered-dose inhaler <4 years: Safety and efficacy not established ≥4 years: 90-180 mcg (1-2 puffs) inhaled PO q4-6 hr Powder metered-dose inhaler (ProAir RespiClick or ProAir Digihaler) <4 years: Safety and efficacy not established ≥4 years: 180 mcg (2 puffs) inhaled PO q4-6hr; not to exceed 12 inhalations/24 hr In some patients 1 inhalation (90 mcg) q4hr may be sufficient Nebulizer solution <2 years (off-label): 0.2-0.6 mg/kg/day divided q4-6hr 2-12 years and <15 kg: 2.5 mg/0.5mL (0.5 % solution) q6-8hr; not to exceed 10 mg (4 vials)/24hr 2-12 years and >15 kg: 1 vial (2.5 mg/3mL) q6-8hr; not to exceed 10 mg (4 vials)/24hr >12 years: 2.5 mg (1 vial) q6-8hr PRN; not to exceed 10 mg/24hr Flow rate of delivery adjusted over period of 5-15 minutes AccuNeb <2 years: Safety and efficacy not established 2-12 years 1 vial (1.25 or 0.63 mg/vial) q6-8hr inhaled PO via nebulizer over 5-15 min; 4 vials (5 mg)/24 hr >12 years: Not studied Tablet <6 years: 0.3-0.6 mg/kg/day PO divided q8hr; not to exceed 12 mg/day 6-12 years: 2 mg PO q6-8hr; may be gradually increased to ≤24 mg/day in divided doses >12 years: 2-4 mg PO q6-8hr; not to exceed 32 mg/day Extended-release Tablet <6 years: Safety and efficacy not established 6-12 years: 4 mg PO q12hr; not to exceed 24 mg/day >12 years: 8 mg PO q12hr; in some patients 4 mg q12hr sufficient Syrup 2-6 years: 0.1 mg (0.25 mL)/kg PO q8hr initially, not to exceed 2 mg (5 mL) q8hr; if necessary, may be increased to 0.2 mg/kg PO q8hr, not to exceed 4 mg (10 mL) q8hr 6-14 years: 2 mg (5 mL) PO q6-8hr; may be gradually increased to ≤24 mg/day in divided doses >14 years: 2-4 mg PO q6-8hr; not to exceed 32 mg/day Exercise-induced Bronchospasm Prevention Aerosol metered-dose inhaler <4 years: Safety and efficacy not established ≥4 years: 180 mcg (2 puffs) inhaled 15-30 min before exercise Powder metered-dose inhaler (ProAir RespiClick or ProAir Digihaler) <4 years: Safety and efficacy not established ≥4 years: 180 mcg (2 puffs) inhaled 15-30 min before exercise Dosing Considerations Potential toxic dose for children <6 years: 1 mg/kg ProAir Digihaler: Contains a QR code and a built-in electronic module which automatically detects, records, and stores data on inhaler events, including peak inspiratory flow rate (L/min)Interaction CheckerEnter a drug name and albuterolNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (4)cisapridealbuterol and cisapride both increase QTc interval. Contraindicated.dronedaronealbuterol and dronedarone both increase QTc interval. Contraindicated.saquinavirsaquinavir, albuterol. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated. Contraindicated. Saquinavir boosted with ritonavir increases risk of hypokalemia, QT prolongation, and cardiac arrhythmias.thioridazinealbuterol and thioridazine both increase QTc interval. Contraindicated.Serious - Use Alternative (21)amitriptylineamitriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amoxapineamoxapine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.azithromycinalbuterol and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.desipraminedesipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.doxepindoxepin, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fexinidazolefexinidazole and albuterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.hydroxychloroquine sulfatealbuterol and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.imipramineimipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.isocarboxazidisocarboxazid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.linezolidlinezolid increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lofepraminelofepramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lopinaviralbuterol and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.maprotilinemaprotiline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.nortriptylinenortriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenelzinephenelzine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.pimozidealbuterol and pimozide both increase QTc interval. Contraindicated.protriptylineprotriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.tranylcyprominetranylcypromine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.trazodonetrazodone, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trimipraminetrimipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Monitor Closely (340)acebutololacebutolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acebutolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.aceclofenacaceclofenac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinacemetacin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilalfentanil increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamalprazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amilorideamiloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amiodaronealbuterol and amiodarone both increase QTc interval. Use Caution/Monitor.amisulpridealbuterol and amisulpride both increase QTc interval. Use Caution/Monitor.amisulpride and albuterol both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.amitriptylineamitriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and amitriptyline both increase QTc interval. Use Caution/Monitor.amobarbitalamobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineamoxapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.anagrelidealbuterol and anagrelide both increase QTc interval. Use Caution/Monitor.apomorphinealbuterol and apomorphine both increase QTc interval. Use Caution/Monitor.arformoterolalbuterol and arformoterol both decrease serum potassium. Use Caution/Monitor.albuterol and arformoterol both decrease sedation. Use Caution/Monitor.albuterol and arformoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.aripiprazolearipiprazole increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilalbuterol and armodafinil both decrease sedation. Use Caution/Monitor.arsenic trioxidealbuterol and arsenic trioxide both increase QTc interval. Use Caution/Monitor.artemether/lumefantrinealbuterol and artemether/lumefantrine both increase QTc interval. Use Caution/Monitor.asenapinealbuterol and asenapine both increase QTc interval. Use Caution/Monitor.asenapine transdermalasenapine transdermal and albuterol both increase QTc interval. Use Caution/Monitor.aspirinaspirin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalaspirin rectal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololatenolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.atomoxetineatomoxetine, albuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of tachycardia, increased blood pressure.azelastineazelastine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bedaquilinealbuterol and bedaquiline both increase QTc interval. Use Caution/Monitor.belladonna and opiumbelladonna and opium increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazidealbuterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.benperidolbenperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetaminealbuterol and benzphetamine both decrease sedation. Use Caution/Monitor.albuterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.betaxololbetaxolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.betaxolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.bisoprololbisoprolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor.brompheniraminebrompheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanidealbuterol and bumetanide both decrease serum potassium. Use Caution/Monitor.buprenorphinebuprenorphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and buprenorphine both increase QTc interval. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.buprenorphine buccal and albuterol both increase QTc interval. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and albuterol both increase QTc interval. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and albuterol both increase QTc interval. Use Caution/Monitor.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and albuterol both increase QTc interval. Use Caution/Monitor.butabarbitalbutabarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalbutalbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolbutorphanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeinealbuterol and caffeine both decrease sedation. Use Caution/Monitor.carbenoxolonealbuterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxaminecarbinoxamine increases and albuterol decreases sedation. Effect of interaction