risk of ventricular arrhythmias.indinavirindinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.indinavirindinavir will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.ipratropiumipratropium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.isofluraneisoflurane and amitriptyline both increase QTc interval. Use Caution/Monitor.isoniazidisoniazid will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.amitriptyline and isoniazid both increase serotonin levels. Modify Therapy/Monitor Closely.isoproterenolchlordiazepoxide increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineistradefylline will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.istradefylline will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of P-gp substrates in clinical trials. Consider dose reduction of sensitive P-gp substrates.itraconazoleitraconazole will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.itraconazole and amitriptyline both increase QTc interval. Use Caution/Monitor.itraconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ivacaftorivacaftor increases levels of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Ivacaftor and its M1 metabolite has the potential to inhibit P-gp; may significantly increase systemic exposure to sensitive P-gp substrates with a narrow therapeutic index.ketamineketamine and chlordiazepoxide both increase sedation. Use Caution/Monitor.ketamineketamine and amitriptyline both increase sedation. Use Caution/Monitor.ketoconazoleketoconazole will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketoconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketoconazole will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.ketotifen, ophthalmicchlordiazepoxide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.amitriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.L-tryptophanamitriptyline and L-tryptophan both increase serotonin levels. Modify Therapy/Monitor Closely.lasmiditanlasmiditan, chlordiazepoxide. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lapatinibamitriptyline and lapatinib both increase QTc interval. Modify Therapy/Monitor Closely.lasmiditanlasmiditan, amitriptyline. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.amitriptyline increases effects of lasmiditan by serotonin levels. Use Caution/Monitor. Coadministration may increase risk of serotonin syndrome.lemborexantlemborexant, amitriptyline. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lemborexant, chlordiazepoxide. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.letermovirletermovir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.letermovir increases levels of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterolamitriptyline increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levofloxacinamitriptyline and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levoketoconazolelevoketoconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levoketoconazolelevoketoconazole will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levoketoconazole will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.levorphanollevorphanol and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and levorphanol both increase sedation. Use Caution/Monitor.levothyroxinelevothyroxine increases effects of amitriptyline by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.lisdexamfetaminechlordiazepoxide increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.liothyronineliothyronine increases effects of amitriptyline by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.liotrixliotrix increases effects of amitriptyline by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.lisdexamfetamineamitriptyline increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline, lisdexamfetamine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s).lithiumamitriptyline and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.lithium and amitriptyline both increase QTc interval. Use Caution/Monitor.lofepramineamitriptyline and lofepramine both increase sedation. Use Caution/Monitor.amitriptyline and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.chlordiazepoxide and lofepramine both increase sedation. Use Caution/Monitor.lofexidinechlordiazepoxide and lofexidine both increase sedation. Use Caution/Monitor.amitriptyline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.amitriptyline and lofexidine both increase sedation. Use Caution/Monitor.lopinavirlopinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.loprazolamloprazolam and amitriptyline both increase sedation. Use Caution/Monitor.loprazolamchlordiazepoxide and loprazolam both increase sedation. Use Caution/Monitor.loratadineloratadine will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.lorazepamchlordiazepoxide and lorazepam both increase sedation. Use Caution/Monitor.lorazepam and amitriptyline both increase sedation. Use Caution/Monitor.lorcaserinlorcaserin will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.lorlatiniblorlatinib will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.lormetazepamchlordiazepoxide and lormetazepam both increase sedation. Use Caution/Monitor.lormetazepam and amitriptyline both increase sedation. Use Caution/Monitor.loxapinechlordiazepoxide and loxapine both increase sedation. Use Caution/Monitor.loxapine and amitriptyline both increase sedation. Use Caution/Monitor.loxapine inhaledchlordiazepoxide and loxapine inhaled both increase sedation. Use Caution/Monitor.loxapine inhaled and amitriptyline both increase sedation. Use Caution/Monitor.lsdamitriptyline and lsd both increase serotonin levels. Modify Therapy/Monitor Closely.lurasidonelurasidone, chlordiazepoxide. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.lurasidonelurasidone increases effects of amitriptyline by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of hypotension with concurrent use. Monitor blood pressure and adjust dose of antihypertensive agent as needed.lurasidone, amitriptyline. Either increases toxicity of the other by sedation. Use Caution/Monitor. Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineamitriptyline and maprotiline both increase sedation. Use Caution/Monitor.amitriptyline and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.chlordiazepoxide and maprotiline both increase sedation. Use Caution/Monitor.maravirocmaraviroc, amitriptyline. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of orthostatic hypotension.marijuanachlordiazepoxide and marijuana both increase sedation. Use Caution/Monitor.marijuanaamitriptyline and marijuana both increase sedation. Use Caution/Monitor.mavacamtenamitriptyline will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. meclizinemeclizine and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.melatoninamitriptyline and melatonin both increase sedation. Use Caution/Monitor.chlordiazepoxide and melatonin both increase sedation. Use Caution/Monitor.meperidinechlordiazepoxide and meperidine both increase sedation. Use Caution/Monitor.meperidine and amitriptyline both increase sedation. Use Caution/Monitor.meprobamateamitriptyline and meprobamate both increase sedation. Use Caution/Monitor.chlordiazepoxide and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolamitriptyline increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonechlordiazepoxide and metaxalone both increase sedation. Use Caution/Monitor.metaxalone and amitriptyline both increase sedation. Use Caution/Monitor.methadonechlordiazepoxide and methadone both increase sedation. Use Caution/Monitor.amitriptyline and methadone both increase QTc interval. Modify Therapy/Monitor Closely.methadone and amitriptyline both increase sedation. Use Caution/Monitor.methamphetaminechlordiazepoxide increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolchlordiazepoxide and methocarbamol both increase sedation. Use Caution/Monitor.methocarbamol and amitriptyline both increase sedation. Use Caution/Monitor.methscopolaminemethscopolamine and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.methylenedioxymethamphetaminechlordiazepoxide increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylenedioxymethamphetamineamitriptyline increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidateamitriptyline, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.methylphenidate transdermalmethylphenidate transdermal will increase the level or effect of amitriptyline by decreasing elimination. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. midazolammidazolam and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midazolam intranasal, amitriptyline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinechlordiazepoxide increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristonemifepristone, amitriptyline. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.mirtazapinechlordiazepoxide and mirtazapine both increase sedation. Use Caution/Monitor.mipomersenmipomersen, amitriptyline. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.mirabegronmirabegron will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.mirtazapineamitriptyline and mirtazapine both increase sedation. Use Caution/Monitor.amitriptyline and mirtazapine both increase serotonin levels. Modify Therapy/Monitor Closely.mitotanemitotane decreases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilchlordiazepoxide increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.modafinil will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.morphineamitriptyline and morphine both increase serotonin levels. Modify Therapy/Monitor Closely.chlordiazepoxide and morphine both increase sedation. Use Caution/Monitor.morphine and amitriptyline both increase sedation. Use Caution/Monitor.motherwortchlordiazepoxide and motherwort both increase sedation. Use Caution/Monitor.amitriptyline and motherwort both increase sedation. Use Caution/Monitor.moxonidinechlordiazepoxide and moxonidine both increase sedation. Use Caution/Monitor.amitriptyline and moxonidine both increase sedation. Use Caution/Monitor.nabilonechlordiazepoxide and nabilone both increase sedation. Use Caution/Monitor.amitriptyline and nabilone both increase sedation. Use Caution/Monitor.nafcillinnafcillin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nalbuphinenalbuphine and amitriptyline both increase sedation. Use Caution/Monitor.nalbuphinechlordiazepoxide and nalbuphine both increase sedation. Use Caution/Monitor.naratriptannaratriptan and amitriptyline both increase serotonin levels. Modify Therapy/Monitor Closely.nefazodonenefazodone will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nefazodone will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.nefopamnefopam, amitriptyline. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Use combination with caution.nelfinavirnelfinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.nelfinavir will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.neostigmineneostigmine increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.norepinephrinechlordiazepoxide increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nicardipinenicardipine will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.nifedipinenifedipine will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.norepinephrineamitriptyline increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases effects of norepinephrine by unknown mechanism. Use Caution/Monitor.nortriptylineamitriptyline and nortriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and nortriptyline both increase sedation. Use Caution/Monitor.amitriptyline and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.ofloxacinamitriptyline and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.olanzapinechlordiazepoxide and olanzapine both increase sedation. Use Caution/Monitor.olanzapineolanzapine and amitriptyline both increase