AdultPediatricDosage Forms & Strengths potassium citrate/citric acid oral solution (1100mg/334mg)/5mL Contains 2 mEq/mL potassium ion equivalent to 2 mEq/mL bicarbonate (HCO3) Urinary Alkalinization Indicated for long-term maintenance of an alkaline urine (eg, patients with uric acid and cystine calculi of the urinary tract), especially when the administration of sodium salts is undesirable or contraindicated Usual dose: 15-30 mL PO diluted with 1 glass of water QID (after meals and at bedtime) Administration Dilute oral solution in water according to directions, followed by additional water, if desired Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations Palatability enhanced if chilledDosage Forms & Strengths potassium citrate/citric acid oral solution (1100mg/334mg)/5mL Contains 2 mEq/mL potassium ion equivalent to 2 mEq/mL bicarbonate (HCO3) Urinary Alkalinization Indicated for long-term maintenance of an alkaline urine (eg, patients with uric acid and cystine calculi of the urinary tract), especially when the administration of sodium salts is undesirable or contraindicated Usual dose: 5-15 mL PO diluted with one-half glass of water QID (after meals and at bedtime) Administration Dilute oral solution in water according to directions, followed by additional water, if desired Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations Palatability enhanced if chilledInteraction CheckerEnter a drug name and potassium citrate/citric acidNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (1)dextroamphetamine transdermalpotassium citrate/citric acid will increase the level or effect of dextroamphetamine transdermal by Other (see comment). Avoid or Use Alternate Drug. Urinary alkalinizing agents can increase blood levels and potentiate the action of amphetamine.Monitor Closely (38)aliskirenaliskiren and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.amilorideamiloride and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.azilsartanazilsartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.benazeprilbenazepril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor. Risk of hyperkalemia.canagliflozincanagliflozin and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.candesartancandesartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.captoprilcaptopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor. Risk of hyperkalemia. Monitor potassium.cyclosporinecyclosporine and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.drospirenonedrospirenone and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.enalaprilenalapril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.eplerenoneeplerenone and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.eprosartaneprosartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.finerenonepotassium citrate/citric acid and finerenone both increase serum potassium. Modify Therapy/Monitor Closely. Finerenone dose adjustment based on current serum potassium concentration. Monitor serum potassium and adjust finerenone dose as described in the prescribing information as necessary.fosinoprilfosinopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.heparinheparin and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.irbesartanirbesartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.lisinoprillisinopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.losartanlosartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.moexiprilmoexipril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.olmesartanolmesartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.pentamidinepentamidine and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.perindoprilperindopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium acid phosphatepotassium acid phosphate and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium chloridepotassium chloride and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium citratepotassium citrate and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium phosphates, IVpotassium phosphates, IV and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.quinaprilquinapril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.ramiprilramipril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.sacubitril/valsartansacubitril/valsartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.spironolactonespironolactone and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.succinylcholinesuccinylcholine and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.tacrolimustacrolimus and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.telmisartantelmisartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.trandolapriltrandolapril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.triamterenetriamterene and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.trimethoprimtrimethoprim and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.valsartanvalsartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.voclosporinvoclosporin and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.Minor (0)aliskirenMonitor Closely (1)aliskiren and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.amilorideMonitor Closely (1)amiloride and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.azilsartanMonitor Closely (1)azilsartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.benazeprilMonitor Closely (1)benazepril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor. Risk of hyperkalemia.canagliflozinMonitor Closely (1)canagliflozin and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.candesartanMonitor Closely (1)candesartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.captoprilMonitor Closely (1)captopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor. Risk of hyperkalemia. Monitor potassium.cyclosporineMonitor Closely (1)cyclosporine and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.dextroamphetamine transdermalSerious - Use Alternative (1)potassium citrate/citric acid will increase the level or effect of dextroamphetamine transdermal by Other (see comment). Avoid or Use Alternate Drug. Urinary alkalinizing agents can increase blood levels and potentiate the action of amphetamine.drospirenoneMonitor Closely (1)drospirenone and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.enalaprilMonitor Closely (1)enalapril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.eplerenoneMonitor Closely (1)eplerenone and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.eprosartanMonitor Closely (1)eprosartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.finerenoneMonitor Closely (1)potassium citrate/citric acid and finerenone both increase serum potassium. Modify Therapy/Monitor Closely. Finerenone dose adjustment based on current serum potassium concentration. Monitor serum potassium and adjust finerenone dose as described in the prescribing information as necessary.fosinoprilMonitor Closely (1)fosinopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.heparinMonitor Closely (1)heparin and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.irbesartanMonitor Closely (1)irbesartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.lisinoprilMonitor Closely (1)lisinopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.losartanMonitor Closely (1)losartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.moexiprilMonitor Closely (1)moexipril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.olmesartanMonitor Closely (1)olmesartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.pentamidineMonitor Closely (1)pentamidine and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.perindoprilMonitor Closely (1)perindopril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium acid phosphateMonitor Closely (1)potassium acid phosphate and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium chlorideMonitor Closely (1)potassium chloride and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium citrateMonitor Closely (1)potassium citrate and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium phosphates, IVMonitor Closely (1)potassium phosphates, IV and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.quinaprilMonitor Closely (1)quinapril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.ramiprilMonitor Closely (1)ramipril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.sacubitril/valsartanMonitor Closely (1)sacubitril/valsartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.spironolactoneMonitor Closely (1)spironolactone and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.succinylcholineMonitor Closely (1)succinylcholine and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.tacrolimusMonitor Closely (1)tacrolimus and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.telmisartanMonitor Closely (1)telmisartan and potassium citrate/citric acid both increase serum potassium. Modify Therapy/Monitor Closely.trandolaprilMonitor Closely (1)trandolapril and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.triamtereneMonitor Closely (1)triamterene and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.trimethoprimMonitor Closely (1)trimethoprim and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.valsartanMonitor Closely (1)valsartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.voclosporinMonitor Closely (1)voclosporin and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor. Frequency Not Defined Hyperkalemia Alkalosis Contraindications Severe renal impairment with oliguria or azotemia Untreated Addison's disease Adynamia episodica hereditaria Acute dehydration Heat cramps Anuria Severe myocardial damage Hyperkalemia from any cause Hypersensitivity to any ingredient Cautions Small bowel lesions (eg, stenosis with or without ulceration) reported with potassium salts (mostly from enteric-coated products) Large doses may cause hyperkalemia and alkalosis, especially in presence of renal disease Caution with low urinary output Direct patients to dilute solution with water before ingestion to minimize GI injury associated with concentrated potassium preparations Take after meals to avoid saline laxative effect Pregnancy Category: C Lactation: Unknown whether distributed in breast milkPregnancy Categories A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk. B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available. Mechanism of Action Potassium citrate is absorbed and metabolized to potassium bicarbonate and this acts as a systemic alkalizer Elimination Excretion: Oxidation of potassium citrate is virtually complete so <5% is excreted in the urine unchanged BRAND FORM. UNIT PRICE PILL IMAGE potassium citrate-citric acid oral- 1,100-334 mg/5 mL solutionpotassium citrate-citric acid oral- 1,100-334 mg/5 mL solutionCytra-K oral- 1,100-334 mg/5 mL solutionCopyright © 2010 First DataBank, Inc.Print Patient Educationpotassium citrate-citric acid oral POTASSIUM CITRATE/CITRIC ACID - ORAL (poe-TAS-ee-um SI-trate/SIT-rik AS-id) COMMON BRAND NAME(S): Polycitra-K USES: This medication is used to make the urine less acidic. This effect helps the kidneys get rid of uric acid, thereby helping to prevent gout and kidney stones. This medication can also prevent and treat certain metabolic problems (acidosis) caused by kidney disease.Citric acid and citrate salts (which contain potassium and sodium) belong to a class of drugs known as urinary alkalinizers. If you have a condition that requires you to limit your intake of potassium and sodium, your doctor may direct you to take a product that is lower in potassium and sodium. HOW TO USE: Take this medication by mouth as directed by your doctor, usually 4 times a day after meals and at bedtime. To help prevent diarrhea, take each dose after a meal. To prevent stomach upset/injury, mix your prescribed dose of medication in cold water or juice as directed. Drink the entire mixture slowly. If you still have stomach upset, mixing your dose in a larger amount of liquid may help unless your doctor directs you otherwise. Ask your doctor or pharmacist for further instructions.The liquid form of this medication must be mixed with at least 4 - 8 ounces (120 - 240 milliliters) of water before taking. Shake the bottle well before each dose and carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you are using the powdered/crystal form of this medication, mix the contents of the packet in at least 3/4 cup (6 ounces or 180 milliliters) of cool water or juice before taking.Refrigerating the mixture before drinking may improve the taste. Drink more water or juice after taking this medication unless otherwise directed by your doctor.Dosage is based on your medical condition and response to treatment.Take this medication exactly as prescribed. Do not increase your dose or take this more often without your doctor's approval. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.While taking this medication, you may need to test the pH (acidity) of your urine using special paper. The pH will help determine the proper dose. Consult your doctor or pharmacist for more information. SIDE EFFECTS: Nausea, vomiting, diarrhea, and stomach pain may occur. Mixing the medication with water or juice, taking it after meals, and drinking more fluids will help prevent these side effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: severe stomach/abdominal pain, tingling/numbness of the hands/feet, weakness, fast/slow/irregular heartbeat, mental/mood changes (such as confusion, restlessness), muscle spasms, seizures, bloody/black/tarry stools, vomit that looks like coffee grounds.A very serious allergic reaction to