lowering benzodiazepine dose.desfluranedesflurane and chlordiazepoxide both increase sedation. Use Caution/Monitor.desipraminechlordiazepoxide and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazinechlordiazepoxide and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.dexfenfluraminechlordiazepoxide increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinechlordiazepoxide and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidatechlordiazepoxide increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminechlordiazepoxide increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramidechlordiazepoxide and dextromoramide both increase sedation. Use Caution/Monitor.diamorphinechlordiazepoxide and diamorphine both increase sedation. Use Caution/Monitor.diazepamchlordiazepoxide and diazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionchlordiazepoxide increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and chlordiazepoxide both increase sedation. Use Caution/Monitor.difenoxin hclchlordiazepoxide and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and chlordiazepoxide both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.diphenoxylate hclchlordiazepoxide and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanonechlordiazepoxide and dipipanone both increase sedation. Use Caution/Monitor.dobutaminechlordiazepoxide increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopaminechlordiazepoxide increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexaminechlordiazepoxide increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinchlordiazepoxide and dosulepin both increase sedation. Use Caution/Monitor.doxepinchlordiazepoxide and doxepin both increase sedation. Use Caution/Monitor.doxylaminechlordiazepoxide and doxylamine both increase sedation. Use Caution/Monitor.droperidolchlordiazepoxide and droperidol both increase sedation. Use Caution/Monitor.duvelisibduvelisib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. will increase the level or effect ofefavirenzefavirenz will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.elagolixelagolix will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.eliglustateliglustat increases levels of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.encorafenibencorafenib, chlordiazepoxide. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.ephedrinechlordiazepoxide increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrinechlordiazepoxide increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicchlordiazepoxide increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, chlordiazepoxide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamchlordiazepoxide and estazolam both increase sedation. Use Caution/Monitor.ethanolchlordiazepoxide and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and chlordiazepoxide both increase sedation. Use Caution/Monitor.etravirineetravirine will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fedratinibfedratinib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.fenfluraminechlordiazepoxide increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinchlordiazepoxide and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazinechlordiazepoxide and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamchlordiazepoxide and flurazepam both increase sedation. Use Caution/Monitor.formoterolchlordiazepoxide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosamprenavirfosamprenavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.fosphenytoinfosphenytoin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.gabapentingabapentin, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxolonechlordiazepoxide and ganaxolone both increase sedation. Use Caution/Monitor.haloperidolchlordiazepoxide and haloperidol both increase sedation. Use Caution/Monitor.hydromorphonechlordiazepoxide and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and chlordiazepoxide both increase sedation. Use Caution/Monitor.iloperidonechlordiazepoxide and iloperidone both increase sedation. Use Caution/Monitor.iloperidone increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imipraminechlordiazepoxide and imipramine both increase sedation. Use Caution/Monitor.indinavirindinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.isoproterenolchlordiazepoxide increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineistradefylline will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleitraconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketamineketamine and chlordiazepoxide both increase sedation. Use Caution/Monitor.ketoconazoleketoconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ketotifen, ophthalmicchlordiazepoxide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, chlordiazepoxide. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantlemborexant, chlordiazepoxide. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.letermovirletermovir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterolchlordiazepoxide increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levoketoconazolelevoketoconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levorphanolchlordiazepoxide and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetaminechlordiazepoxide increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepraminechlordiazepoxide and lofepramine both increase sedation. Use Caution/Monitor.lofexidinechlordiazepoxide and lofexidine both increase sedation. Use Caution/Monitor.lopinavirlopinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.loprazolamchlordiazepoxide and loprazolam both increase sedation. Use Caution/Monitor.lorazepamchlordiazepoxide and lorazepam both increase sedation. Use Caution/Monitor.lorlatiniblorlatinib will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.lormetazepamchlordiazepoxide and lormetazepam both increase sedation. Use Caution/Monitor.loxapinechlordiazepoxide and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledchlordiazepoxide and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, chlordiazepoxide. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilinechlordiazepoxide and maprotiline both increase sedation. Use Caution/Monitor.marijuanachlordiazepoxide and marijuana both increase sedation. Use Caution/Monitor.melatoninchlordiazepoxide and melatonin both increase sedation. Use Caution/Monitor.meperidinechlordiazepoxide and meperidine both increase sedation. Use Caution/Monitor.meprobamatechlordiazepoxide and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolchlordiazepoxide increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonechlordiazepoxide and metaxalone both increase sedation. Use Caution/Monitor.methadonechlordiazepoxide and methadone both increase sedation. Use Caution/Monitor.methamphetaminechlordiazepoxide increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolchlordiazepoxide and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminechlordiazepoxide increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolamchlordiazepoxide and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinechlordiazepoxide increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapinechlordiazepoxide and mirtazapine both increase sedation. Use Caution/Monitor.mitotanemitotane decreases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.modafinilchlordiazepoxide increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinechlordiazepoxide and morphine both increase sedation. Use Caution/Monitor.motherwortchlordiazepoxide and motherwort both increase sedation. Use Caution/Monitor.moxonidinechlordiazepoxide and moxonidine both increase sedation. Use Caution/Monitor.nabilonechlordiazepoxide and nabilone both increase sedation. Use Caution/Monitor.nafcillinnafcillin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nalbuphinechlordiazepoxide and nalbuphine both increase sedation. Use Caution/Monitor.nelfinavirnelfinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.norepinephrinechlordiazepoxide increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinechlordiazepoxide and nortriptyline both increase sedation. Use Caution/Monitor.olanzapinechlordiazepoxide and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, chlordiazepoxide. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tincturechlordiazepoxide and opium tincture both increase sedation. Use Caution/Monitor.orphenadrinechlordiazepoxide and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamchlordiazepoxide and oxazepam both increase sedation. Use Caution/Monitor.oxycodonechlordiazepoxide and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonechlordiazepoxide and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonechlordiazepoxide and paliperidone both increase sedation. Use Caution/Monitor.papaveretumchlordiazepoxide and papaveretum both increase sedation. Use Caution/Monitor.papaverinechlordiazepoxide and papaverine both increase sedation. Use Caution/Monitor.pentazocinechlordiazepoxide and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.perampanelperampanel and chlordiazepoxide both increase sedation. Use Caution/Monitor.perphenazinechlordiazepoxide and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazinechlordiazepoxide increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.phenobarbital will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phenterminechlordiazepoxide increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinechlordiazepoxide increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POchlordiazepoxide increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinphenytoin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.pholcodinechlordiazepoxide and pholcodine both increase sedation. Use Caution/Monitor.pimozidechlordiazepoxide and pimozide both increase sedation. Use Caution/Monitor.pirbuterolchlordiazepoxide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleposaconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pregabalinpregabalin, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and chlordiazepoxide both increase sedation. Use Caution/Monitor.primidone will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.prochlorperazinechlordiazepoxide and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and chlordiazepoxide both increase sedation. Use Caution/Monitor.propofolpropofol and chlordiazepoxide both increase sedation. Use Caution/Monitor.propylhexedrinechlordiazepoxide increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinechlordiazepoxide and protriptyline both increase sedation. Use Caution/Monitor.quazepamchlordiazepoxide and quazepam both increase sedation. Use Caution/Monitor.quetiapinechlordiazepoxide and quetiapine both increase sedation. Use Caution/Monitor.ramelteonchlordiazepoxide and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, chlordiazepoxide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibribociclib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinrifabutin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifampinrifampin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.risperidonechlordiazepoxide and risperidone both increase sedation. Use Caution/Monitor.ritonavirritonavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.