AdultPediatricDosage Forms & Strengths tablet 10mg 25mg 50mg 100mg 200mg injectable solution 25mg/mL Schizophrenia, Psychotic Disorders PO: 30-75 mg/day divided q6-12hr initially; maintenance: usually 200 mg/day (up to 800 mg/day in some patients; some patients may require 1-2 g/day) IV/IM: 25 mg initially, followed PRN with 25-50 mg after 1-4 hours, then increased to maximum of 400 mg q4-6hr until patient is controlled; usual dosage 300-800 mg/day Nausea & Vomiting PO: 10-25 mg q4-6hr PRN IV/IM: 25-50 mg q4-6hr PRN Preoperative Apprehension 25-50 mg PO 2-3 hours before surgery 12.5-25 mg IM 1-2 hours before surgery Intraoperative Sedation 12.5 IM q30min or 2 mg IV q2min; total dose not to exceed 25 mg Intractable Hiccups 25-50 mg PO q6-8hr; if hiccups persist after 2-3 days of oral therapy, administer 25-50 mg IM q3-4hr; if symptoms persist, administer 25-50 mg by slow IV infusion with patient lying flat in bed; monitor BP Acute Intermittent Porphyria 25-50 mg PO q6-8hr Migraine Headache (Off-label) 5-50 mg IV as single doseDosage Forms & Strengths tablet 10mg 25mg 50mg 100mg 200mg injectable solution 25mg/mL Behavioral Disorders, Hyperactivity <6 months: Safety and efficacy not established ≥6 months: 50-100 mg/day PO/IM; 200 mg/day or more may be necessary for older hospitalized patients; for outpatients, may administer 0.55 mg/kg q4-6hr PRN Nausea & Vomiting <6 months: Safety and efficacy not established ≥6 months: 0.5-1 mg/kg PO/IM q6-8hr PRN Preoperative Apprehension <6 months: Safety and efficacy not established ≥6 months: 0.55 mg/kg PO/IM 1-2 hours before surgery Interaction CheckerEnter a drug name and chlorpromazineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (11)amisulprideamisulpride, chlorpromazine. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndrome.disopyramidechlorpromazine and disopyramide both increase QTc interval. Contraindicated.eliglustatchlorpromazine increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given concomitantly with strong or moderate CYP3A inhibitors.ibutilidechlorpromazine and ibutilide both increase QTc interval. Contraindicated.indapamidechlorpromazine and indapamide both increase QTc interval. Contraindicated.metrizamidechlorpromazine, metrizamide. Mechanism: unknown. Contraindicated. Risk of seizure. D/C phenothiazine 24h before admin. of metrizamide.pentamidinechlorpromazine and pentamidine both increase QTc interval. Contraindicated.pimozidechlorpromazine and pimozide both increase QTc interval. Contraindicated.procainamidechlorpromazine and procainamide both increase QTc interval. Contraindicated.quinidinechlorpromazine and quinidine both increase QTc interval. Contraindicated.sotalolchlorpromazine and sotalol both increase QTc interval. Contraindicated.Serious - Use Alternative (145)adagrasibadagrasib, chlorpromazine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.alfuzosinalfuzosin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.aminolevulinic acid oralaminolevulinic acid oral, chlorpromazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.aminolevulinic acid topicalchlorpromazine increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid.amiodaronechlorpromazine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulpridechlorpromazine and amisulpride both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylinechlorpromazine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amoxapinechlorpromazine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.anagrelideanagrelide and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.apomorphinechlorpromazine decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.apomorphine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.aripiprazolearipiprazole and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxidechlorpromazine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinechlorpromazine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapineasenapine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.atomoxetineatomoxetine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, chlorpromazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).benzhydrocodone/acetaminophen and chlorpromazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebromocriptinechlorpromazine decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.buprenorphinebuprenorphine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implant and chlorpromazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalbuprenorphine transdermal and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermal and chlorpromazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionbuprenorphine, long-acting injection and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injection and chlorpromazine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebupropionchlorpromazine increases toxicity of bupropion by unspecified interaction mechanism. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible.cabergolinechlorpromazine decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.calcium/magnesium/potassium/sodium oxybateschlorpromazine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carvedilolcarvedilol, chlorpromazine. Either increases levels of the other by decreasing metabolism. Contraindicated. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact).ceritinibceritinib and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.chloroquinechloroquine increases toxicity of chlorpromazine by QTc interval. Avoid or Use Alternate Drug.clarithromycinchlorpromazine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipraminechlorpromazine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.clozapineclozapine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. degarelixdegarelix and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.desfluranedesflurane and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.desipraminechlorpromazine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.dofetilidechlorpromazine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dofetilide increases toxicity of chlorpromazine by QTc interval. Avoid or Use Alternate Drug.donepezildonepezil and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.dopaminechlorpromazine decreases effects of dopamine by pharmacodynamic antagonism. Contraindicated.dosulepinchlorpromazine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.doxepinchlorpromazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.dronedaronechlorpromazine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolchlorpromazine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.efavirenzefavirenz and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.eliglustateliglustat and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.encorafenibencorafenib and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.entrectinibchlorpromazine and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.epinephrineepinephrine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicepinephrine racemic and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.eribulineribulin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. Potential for enhanced QTc-prolonging effects; if concurrent use is necessary then ECG monitoring is recommended.erythromycin basechlorpromazine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatechlorpromazine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatechlorpromazine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatechlorpromazine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramescitalopram increases toxicity of chlorpromazine by QTc interval. Avoid or Use Alternate Drug.fentanylfentanyl, chlorpromazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalfentanyl intranasal, chlorpromazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, chlorpromazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, chlorpromazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fexinidazolefexinidazole and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.fingolimodfingolimod and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.fluconazolechlorpromazine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluphenazinechlorpromazine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.formoterolchlorpromazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.gadobenategadobenate and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.gemifloxacingemifloxacin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.gilteritinibgilteritinib and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.glasdegibchlorpromazine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.granisetrongranisetron and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.haloperidolchlorpromazine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydrocodonehydrocodone, chlorpromazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).hydroxychloroquine sulfatehydroxychloroquine sulfate and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.imipraminechlorpromazine and imipramine both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabinotuzumab and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.isofluraneisoflurane and chlorpromazine both