AdultPediatricGeriatricDosage Forms & Strengths tablets 2mg 4mg 8mg 16mg Intractable Hiccoughs (Off-label) 8-16 mg PO qDay divided q8-12hr Maximum: 24 mg Treatment of Nausea/Vomiting 8-16 mg PO qDay divided q6-12hr Maximum: 24 mg Schizophrenia Hospitalized patients: 8-16mg PO q6-12hr Hospitalized patients: Not to exceed 64 mg/day divided q6-12hr Outpatients: 4-8mg PO q8hr; reduce as soon as possible to minimum effective dose Hepatic Impairment Dose adjustment not described in manufacturer's labeling Renal Impairment Dose adjustment not described in manufacturer's labelingDosage Forms & Strengths tablets 2mg 4mg 8mg 16mg Intractable Hiccoughs (Off-label) <12 years Not recommended by manufacturer >12 years 8-16 mg PO qDay divided q8-12hr Maximum: 24 mg Schizophrenia <12 years Not recommended by manufacturer >12 years Hospitalized patients: 8-16mg PO q6-12hr Hospitalized patients: Not to exceed 64 mg/day divided q6-12hr Outpatients: 4-8mg PO q8hr; reduce as soon as possible to minimum effective dose Initiate dosing at lower end of the range Intractable Hiccoughs 8-16 mg PO qDay divided q8-12hr Maximum: 24 mg Treatment of Nausea/Vomiting 8-16 mg PO qDay divided q6-12hr Maximum: 24 mg Schizophrenia Hospitalized patients: 8-16mg PO q6-12hr Hospitalized patients: Not to exceed 64 mg/day divided q6-12hr Outpatients: 4-8mg PO q8hr; reduce as soon as possible to minimum effective doseInteraction CheckerEnter a drug name and perphenazineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (11)amisulprideamisulpride, perphenazine. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndrome.disopyramideperphenazine and disopyramide both increase QTc interval. Contraindicated.fezolinetantperphenazine will increase the level or effect of fezolinetant by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Fezolinetant AUC and peak plasma concentration are increased if coadministered with drugs that are weak, moderate, or strong CYP1A2 inhibitorsibutilideperphenazine and ibutilide both increase QTc interval. Contraindicated.indapamideperphenazine and indapamide both increase QTc interval. Contraindicated.metrizamideperphenazine, metrizamide. Mechanism: unknown. Contraindicated. Risk of seizure. D/C phenothiazine 24h before admin. of metrizamide.pentamidineperphenazine and pentamidine both increase QTc interval. Contraindicated.pimozideperphenazine and pimozide both increase QTc interval. Contraindicated.procainamideperphenazine and procainamide both increase QTc interval. Contraindicated.quinidineperphenazine and quinidine both increase QTc interval. Contraindicated.sotalolperphenazine and sotalol both increase QTc interval. Contraindicated.Serious - Use Alternative (96)adagrasibadagrasib, perphenazine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.aminolevulinic acid oralaminolevulinic acid oral, perphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.aminolevulinic acid topicalperphenazine increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid.amiodaroneperphenazine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideperphenazine and amisulpride both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineperphenazine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amoxapineperphenazine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.apomorphineperphenazine decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.apomorphine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.aripiprazolearipiprazole and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxideperphenazine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineperphenazine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, perphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).bromocriptineperphenazine decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.cabergolineperphenazine decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.calcium/magnesium/potassium/sodium oxybatesperphenazine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.chlorpromazinechlorpromazine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinperphenazine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineperphenazine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. degarelixdegarelix and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.desipramineperphenazine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.dofetilideperphenazine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dopamineperphenazine decreases effects of dopamine by pharmacodynamic antagonism. Contraindicated.dosulepinperphenazine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.doxepinperphenazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.dronedaroneperphenazine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolperphenazine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.epinephrineepinephrine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicepinephrine racemic and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseperphenazine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateperphenazine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateperphenazine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateperphenazine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.fentanylfentanyl, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalfentanyl intranasal, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fluconazoleperphenazine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.perphenazine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.perphenazine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.fluphenazinefluphenazine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.formoterolperphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.haloperidolperphenazine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydrocodonehydrocodone, perphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).hydroxychloroquine sulfatehydroxychloroquine sulfate and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.imipramineperphenazine and imipramine both increase QTc interval. Avoid or Use Alternate Drug.isocarboxazidisocarboxazid, perphenazine. Other (see comment). Contraindicated. Comment: Concurrent use may prolong or intensify the hypotensive, anticholinergic, or sedative effects of isocarboxazid or perphenazine.itraconazoleperphenazine and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib and perphenazine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazoleperphenazine and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levodopaperphenazine decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug.levodopa inhaledperphenazine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Phenothiazine/1st generation antipsychotics inhibit dopamine D2 receptors in varying degrees.levoketoconazoleperphenazine and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lisurideperphenazine decreases effects of lisuride by pharmacodynamic antagonism. Contraindicated.lofepramineperphenazine and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.lorcaserinperphenazine and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.lumefantrineperphenazine and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and perphenazine both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilineperphenazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.methyl aminolevulinateperphenazine, methyl aminolevulinate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.methyldopaperphenazine decreases effects of methyldopa by pharmacodynamic antagonism. Contraindicated.metoclopramide intranasalperphenazine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.perphenazine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.mobocertinibmobocertinib and perphenazine both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinperphenazine and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotinibperphenazine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.nortriptylineperphenazine and nortriptyline both increase QTc interval. Avoid or Use Alternate Drug.octreotideperphenazine and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)perphenazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasalperphenazine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronperphenazine and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.paroxetineparoxetine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.perphenazine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.perphenazine and paroxetine both increase QTc interval. Avoid or Use Alternate Drug.pramipexoleperphenazine decreases effects of pramipexole by pharmacodynamic antagonism. Contraindicated.prochlorperazineperphenazine and prochlorperazine both increase QTc interval. Avoid or Use Alternate Drug.promazineperphenazine and promazine both increase QTc interval. Avoid or Use Alternate Drug.promethazineperphenazine and promethazine both increase QTc interval. Avoid or Use Alternate Drug.protriptylineperphenazine and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.quinidinequinidine, perphenazine. Either increases effects of