lofexidine both increase sedation. Use Caution/Monitor.ozanimodozanimod and lofexidine both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidonepaliperidone and lofexidine both increase sedation. Use Caution/Monitor.paliperidone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.papaveretumpapaveretum and lofexidine both increase sedation. Use Caution/Monitor.papaverinelofexidine and papaverine both increase sedation. Use Caution/Monitor.paroxetineparoxetine will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.pentazocinepentazocine and lofexidine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and lofexidine both increase sedation. Use Caution/Monitor.perphenazineperphenazine and lofexidine both increase sedation. Use Caution/Monitor.phendimetrazinelofexidine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and lofexidine both increase sedation. Use Caution/Monitor.phenterminelofexidine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinelofexidine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POlofexidine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinelofexidine and pholcodine both increase sedation. Use Caution/Monitor.pimavanserinpimavanserin and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.pimozidepimozide and lofexidine both increase sedation. Use Caution/Monitor.pimozide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.pirbuterollofexidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.primidoneprimidone and lofexidine both increase sedation. Use Caution/Monitor.procainamideprocainamide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.prochlorperazineprochlorperazine and lofexidine both increase sedation. Use Caution/Monitor.promethazinepromethazine and lofexidine both increase sedation. Use Caution/Monitor.propofolpropofol and lofexidine both increase sedation. Use Caution/Monitor.propylhexedrinelofexidine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineprotriptyline and lofexidine both increase sedation. Use Caution/Monitor.protriptyline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.quazepamquazepam and lofexidine both increase sedation. Use Caution/Monitor.quetiapinequetiapine and lofexidine both increase sedation. Use Caution/Monitor.quetiapine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.quinidinequinidine will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.quinidine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.ramelteonlofexidine and ramelteon both increase sedation. Use Caution/Monitor.ribociclibribociclib and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.risperidonerisperidone and lofexidine both increase sedation. Use Caution/Monitor.ritonavirritonavir will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.rolapitantrolapitant will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.salmeterollofexidine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcaplofexidine and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and lofexidine both increase sedation. Use Caution/Monitor.selpercatinibselpercatinib increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.sevofluranesevoflurane and lofexidine both increase sedation. Use Caution/Monitor.shepherd's purselofexidine and shepherd's purse both increase sedation. Use Caution/Monitor.solifenacinsolifenacin and lofexidine both increase QTc interval. Use Caution/Monitor.sotalolsotalol and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.stiripentolstiripentol, lofexidine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanilsufentanil and lofexidine both increase sedation. Use Caution/Monitor.tapentadoltapentadol and lofexidine both increase sedation. Use Caution/Monitor.temazepamtemazepam and lofexidine both increase sedation. Use Caution/Monitor.terbutalinelofexidine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.tetrabenazinetetrabenazine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.thioridazinethioridazine and lofexidine both increase sedation. Use Caution/Monitor.thioridazine will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.thioridazine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.thiothixenethiothixene and lofexidine both increase sedation. Use Caution/Monitor.tipranavirtipranavir will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.topiramatelofexidine and topiramate both increase sedation. Modify Therapy/Monitor Closely.toremifenetoremifene and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.tramadoltramadol and lofexidine both increase sedation. Use Caution/Monitor.trazodonetrazodone and lofexidine both increase sedation. Use Caution/Monitor.trazodone decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.triazolamtriazolam and lofexidine both increase sedation. Use Caution/Monitor.triclabendazoletriclabendazole and lofexidine both increase QTc interval. Use Caution/Monitor.triclofostriclofos and lofexidine both increase sedation. Use Caution/Monitor.trifluoperazinetrifluoperazine and lofexidine both increase sedation. Use Caution/Monitor.trimipraminetrimipramine and lofexidine both increase sedation. Use Caution/Monitor.trimipramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.triprolidinetriprolidine and lofexidine both increase sedation. Use Caution/Monitor.valbenazinevalbenazine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.vandetanibvandetanib and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.vemurafenibvemurafenib and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.voclosporinvoclosporin, lofexidine. Either increases effects of the other by QTc interval. Use Caution/Monitor.xylometazolinelofexidine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinelofexidine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidelofexidine and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneziprasidone and lofexidine both increase sedation. Use Caution/Monitor.ziprasidone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.Minor (2)eucalyptuseucalyptus and lofexidine both increase sedation. Minor/Significance Unknown.sagelofexidine and sage both increase sedation. Minor/Significance Unknown.abirateroneMonitor Closely (1)abiraterone will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.acebutololSerious - Use Alternative (1)lofexidine, acebutolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.adagrasibSerious - Use Alternative (1)adagrasib, lofexidine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolMonitor Closely (2)albuterol and lofexidine both increase QTc interval. Use Caution/Monitor. lofexidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil and lofexidine both increase sedation. Use Caution/Monitor.alfuzosinMonitor Closely (1)lofexidine and alfuzosin both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)alfuzosin and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.alprazolamMonitor Closely (1)alprazolam and lofexidine both increase sedation. Use Caution/Monitor.alprostadil IVSerious - Use Alternative (1)lofexidine, alprostadil IV. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.amilorideSerious - Use Alternative (1)lofexidine, amiloride. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.amiodaroneMonitor Closely (1)amiodarone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.amisulprideSerious - Use Alternative (1)amisulpride and lofexidine both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineMonitor Closely (2)amitriptyline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. amitriptyline and lofexidine both increase sedation. Use Caution/Monitor.amlodipineSerious - Use Alternative (1)lofexidine, amlodipine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.amobarbitalMonitor Closely (1)amobarbital and lofexidine both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (2)amoxapine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. amoxapine and lofexidine both increase sedation. Use Caution/Monitor.amyl nitriteSerious - Use Alternative (1)lofexidine, amyl nitrite. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.anagrelideMonitor Closely (1)anagrelide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.apomorphineSerious - Use Alternative (1)apomorphine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.arformoterolMonitor Closely (2)arformoterol and lofexidine both increase QTc interval. Use Caution/Monitor. lofexidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (2)aripiprazole and lofexidine both increase QTc interval. Use Caution/Monitor. aripiprazole and lofexidine both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)lofexidine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arsenic trioxideMonitor Closely (1)arsenic trioxide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.artemetherMonitor Closely (1)artemether and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.asenapineMonitor Closely (1)asenapine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.asenapine transdermalMonitor Closely (1)asenapine transdermal and lofexidine both increase QTc interval. Use Caution/Monitor.atenololSerious - Use Alternative (1)lofexidine, atenolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.atomoxetineMonitor Closely (1)atomoxetine and lofexidine both increase QTc interval. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and lofexidine both increase sedation. Use Caution/Monitor.azilsartanSerious - Use Alternative (1)lofexidine, azilsartan. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.azithromycinMonitor Closely (1)azithromycin increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.baclofenMonitor Closely (1)baclofen and lofexidine both increase sedation. Use Caution/Monitor.bedaquilineSerious - Use Alternative (1)bedaquiline and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.belladonna and opiumMonitor Closely (1)belladonna and opium and lofexidine both increase sedation. Use Caution/Monitor.benazeprilSerious - Use Alternative (1)lofexidine, benazepril. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.bendroflumethiazideSerious - Use Alternative (1)lofexidine, bendroflumethiazide. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.benperidolMonitor Closely (1)benperidol and lofexidine both increase sedation. Use Caution/Monitor.benzphetamineMonitor Closely (1)lofexidine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.betaxololSerious - Use Alternative (1)lofexidine, betaxolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.bisoprololSerious - Use Alternative (1)lofexidine, bisoprolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.bosentanSerious - Use Alternative (1)lofexidine, bosentan. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.brompheniramineMonitor Closely (1)brompheniramine and lofexidine both increase sedation. Use Caution/Monitor.bumetanideSerious - Use Alternative (1)lofexidine, bumetanide. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.buprenorphineMonitor Closely (1)buprenorphine and lofexidine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine and lofexidine both increase QTc