are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.ceritinibceritinib and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.ceritinib will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chloramphenicolchloramphenicol will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chloroquinechloroquine and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazinebuprenorphine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.cimetidinecimetidine increases effects of buprenorphine by decreasing metabolism. Avoid or Use Alternate Drug.ciprofloxacinbuprenorphine and ciprofloxacin both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinclarithromycin will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.clarithromycin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.clomipraminebuprenorphine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.clonidineclonidine, buprenorphine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration enhances CNS depressant effects.clozapineclozapine and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.codeinebuprenorphine, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.conivaptanconivaptan will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.crizotinibcrizotinib and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.dasatinibdasatinib and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.degarelixdegarelix and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.desfluranedesflurane and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.desipraminebuprenorphine and desipramine both increase QTc interval. Avoid or Use Alternate Drug.dextromoramidebuprenorphine, dextromoramide. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.diamorphinebuprenorphine, diamorphine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.diazepam intranasaldiazepam intranasal, buprenorphine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.difenoxin hclbuprenorphine, difenoxin hcl. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.diphenoxylate hclbuprenorphine, diphenoxylate hcl. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.dipipanonebuprenorphine, dipipanone. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.disopyramidebuprenorphine and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dofetilidebuprenorphine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetrondolasetron and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.donepezildonepezil and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.doxepindoxepin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.efavirenzefavirenz and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.eliglustatbuprenorphine and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.eluxadolinebuprenorphine, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions. .encorafenibencorafenib and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.entrectinibentrectinib and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.eribulineribulin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.erythromycin basebuprenorphine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatebuprenorphine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatebuprenorphine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatebuprenorphine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitaloprambuprenorphine and escitalopram both increase QTc interval. Avoid or Use Alternate Drug.fentanylfentanyl, buprenorphine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.buprenorphine decreases effects of fentanyl by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may reduce fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.fentanyl intranasalfentanyl intranasal, buprenorphine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.buprenorphine decreases effects of fentanyl intranasal by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may reduce fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.fentanyl transdermalfentanyl transdermal, buprenorphine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.buprenorphine decreases effects of fentanyl transdermal by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may reduce fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.fentanyl transmucosalfentanyl transmucosal, buprenorphine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.buprenorphine decreases effects of fentanyl transmucosal by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may reduce fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.fexinidazolefexinidazole and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.fexinidazole will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.fingolimodfingolimod and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.flecainidebuprenorphine and flecainide both increase QTc interval. Avoid or Use Alternate Drug.fluconazolebuprenorphine and fluconazole both increase QTc interval. Contraindicated.fluoxetinebuprenorphine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.fluvoxaminebuprenorphine and fluvoxamine both increase QTc interval. Avoid or Use Alternate Drug.foscarnetbuprenorphine and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.fostemsavirbuprenorphine and fostemsavir both increase QTc interval. Avoid or Use Alternate Drug.gemifloxacingemifloxacin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.gemtuzumabbuprenorphine and gemtuzumab both increase QTc interval. Avoid or Use Alternate Drug.gilteritinibgilteritinib and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.glasdegibbuprenorphine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.goserelinbuprenorphine and goserelin both increase QTc interval. Avoid or Use Alternate Drug.granisetrongranisetron and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.haloperidolbuprenorphine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.histrelinbuprenorphine and histrelin both increase QTc interval. Avoid or Use Alternate Drug.hydrocodonebuprenorphine decreases effects of hydrocodone by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Mixed opioid agonists/antagonists and partial opioid agonists may reduce the analgesic effect of hydrocodone and/or precipitate withdrawal symptoms in opioid tolerant patients. .hydrocodone, buprenorphine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphonebuprenorphine, hydromorphone. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.hydroxychloroquine sulfatebuprenorphine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.ibutilidebuprenorphine and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.idelalisibidelalisib will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substratesiloperidonebuprenorphine and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.imipraminebuprenorphine and imipramine both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabbuprenorphine and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.isocarboxazidisocarboxazid increases toxicity of buprenorphine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.isofluraneisoflurane and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.itraconazoleitraconazole will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.itraconazole and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib will decrease the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.buprenorphine and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.ketoconazoleketoconazole will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.lapatinibbuprenorphine and lapatinib both increase QTc interval. Avoid or Use Alternate Drug.lefamulinbuprenorphine and lefamulin both increase QTc interval. Avoid or Use Alternate Drug.lenvatinibbuprenorphine and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.leuprolidebuprenorphine and leuprolide both increase QTc interval. Avoid or Use Alternate Drug.levofloxacinbuprenorphine and levofloxacin both increase QTc interval. Avoid or Use Alternate Drug.levoketoconazolelevoketoconazole will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.levorphanolbuprenorphine, levorphanol. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.linezolidlinezolid increases toxicity of buprenorphine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.lithiumlithium and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.lofexidinebuprenorphine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.lonafarniblonafarnib will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.loperamidebuprenorphine and loperamide both increase QTc interval. Avoid or Use Alternate Drug.lopinavirbuprenorphine and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.macimorelinbuprenorphine and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.mefloquinebuprenorphine and mefloquine both increase QTc interval. Avoid or Use Alternate Drug.meperidinebuprenorphine, meperidine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.methadonebuprenorphine, methadone. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.buprenorphine and methadone both increase QTc interval. Avoid or Use Alternate Drug.methylene bluemethylene blue and buprenorphine both increase serotonin levels. Avoid or Use Alternate Drug. If drug combination must be administered, monitor for evidence of serotonergic or opioid-related toxicitiesmetoclopramide intranasalbuprenorphine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midostaurinbuprenorphine and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mifepristonemifepristone will increase the level or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.