days of stopping trazodone.remimazolamMonitor Closely (1)remimazolam, trazodone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.repaglinideMinor (1)trazodone increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown.ribociclibSerious - Use Alternative (1)ribociclib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifabutinMonitor Closely (1)rifabutin decreases levels of trazodone by increasing metabolism. Use Caution/Monitor.Serious - Use Alternative (1)rifabutin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifampinSerious - Use Alternative (1)rifampin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifapentineSerious - Use Alternative (1)rifapentine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.risperidoneMonitor Closely (3)trazodone will decrease the level or effect of risperidone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. trazodone and risperidone both increase QTc interval. Modify Therapy/Monitor Closely. risperidone and trazodone both increase sedation. Use Caution/Monitor.ritonavirMonitor Closely (2)trazodone will decrease the level or effect of ritonavir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. ritonavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.rivastigmineMinor (1)rivastigmine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.rizatriptanMonitor Closely (1)rizatriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.Minor (1)trazodone, rizatriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.rocuroniumMonitor Closely (1)rocuronium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.romidepsinMonitor Closely (1)trazodone will decrease the level or effect of romidepsin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.rosiglitazoneMinor (1)trazodone increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown.rosuvastatinMinor (1)trazodone increases levels of rosuvastatin by unspecified interaction mechanism. Minor/Significance Unknown.rucaparibMonitor Closely (1)rucaparib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.rufinamideMonitor Closely (1)rufinamide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ruxolitinibMinor (1)trazodone will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.ruxolitinib topicalMinor (1)trazodone will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.safinamideContraindicated (1)trazodone, safinamide. Either increases toxicity of the other by serotonin levels. Contraindicated. Concomitant use could result in life-threatening serotonin syndrome.sageMinor (1)trazodone and sage both increase sedation. Minor/Significance Unknown.salicylates (non-asa)Monitor Closely (1)trazodone, salicylates (non-asa). Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.salmeterolMonitor Closely (1)trazodone increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)trazodone, salmeterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.salsalateMonitor Closely (1)trazodone, salsalate. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.SAMeMonitor Closely (1)trazodone and SAMe both increase serotonin levels. Modify Therapy/Monitor Closely.saquinavirContraindicated (2)trazodone will decrease the level or effect of saquinavir by P-glycoprotein (MDR1) efflux transporter. Contraindicated. saquinavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.saxagliptinMinor (1)trazodone increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown.scopolamineMonitor Closely (1)scopolamine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.scullcapMonitor Closely (1)trazodone and scullcap both increase sedation. Use Caution/Monitor.secobarbitalMonitor Closely (2)secobarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. secobarbital and trazodone both increase sedation. Use Caution/Monitor.Minor (1)secobarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.selegilineSerious - Use Alternative (1)selegiline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.selegiline transdermalSerious - Use Alternative (1)selegiline transdermal and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.serdexmethylphenidate/dexmethylphenidateSerious - Use Alternative (1)trazodone, serdexmethylphenidate/dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of trazodone by decreasing metabolism. Minor/Significance Unknown.sertralineSerious - Use Alternative (2)sertraline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug. sertraline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.sevofluraneMonitor Closely (1)sevoflurane and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)sevoflurane and trazodone both increase QTc interval. Avoid or Use Alternate Drug.Minor (1)sevoflurane, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.shepherd's purseMonitor Closely (1)trazodone and shepherd's purse both increase sedation. Use Caution/Monitor.silodosinMonitor Closely (1)trazodone will decrease the level or effect of silodosin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.simvastatinMinor (1)trazodone increases levels of simvastatin by unspecified interaction mechanism. Minor/Significance Unknown.siponimodSerious - Use Alternative (1)siponimod and trazodone both increase QTc interval. Avoid or Use Alternate Drug.sirolimusMonitor Closely (1)trazodone will decrease the level or effect of sirolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.sitagliptinMinor (1)trazodone increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown.sodium oxybateSerious - Use Alternative (1)trazodone, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.solifenacinMonitor Closely (1)solifenacin and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (1)solifenacin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.sotalolContraindicated (1)trazodone and sotalol both increase QTc interval. Contraindicated.St John's WortSerious - Use Alternative (2)trazodone and St John's Wort both increase serotonin levels. Avoid or Use Alternate Drug. St John's Wort will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.stiripentolMonitor Closely (1)stiripentol, trazodone. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.streptomycinMonitor Closely (1)trazodone will decrease the level or effect of streptomycin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.succinylcholineMinor (1)succinylcholine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.sufentanilMonitor Closely (1)sufentanil and trazodone both increase sedation. Use Caution/Monitor.sufentanil SLMonitor Closely (1)sufentanil SL, trazodone. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.sulfamethoxazoleMonitor Closely (1)trazodone and sulfamethoxazole both increase QTc interval. Modify Therapy/Monitor Closely.Minor (1)sulfamethoxazole decreases levels of trazodone by unspecified interaction mechanism. Minor/Significance Unknown.sulfasalazineMonitor Closely (1)trazodone, sulfasalazine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.sulindacMonitor Closely (1)trazodone, sulindac. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.sumatriptanMonitor Closely (1)sumatriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.Minor (1)trazodone, sumatriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.sumatriptan intranasalMonitor Closely (1)sumatriptan intranasal and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.Minor (1)trazodone, sumatriptan intranasal. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.sunitinibSerious - Use Alternative (1)sunitinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.tacrolimusMonitor Closely (1)trazodone will decrease the level or effect of tacrolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.Serious - Use Alternative (1)tacrolimus and trazodone both increase QTc interval. Avoid or Use Alternate Drug.tamsulosinMonitor Closely (1)trazodone increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.tapentadolMonitor Closely (2)trazodone and tapentadol both increase serotonin levels. Modify Therapy/Monitor Closely. tapentadol and trazodone both increase sedation. Use Caution/Monitor.tazemetostatMonitor Closely (2)tazemetostat will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. trazodone will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tecovirimatMonitor Closely (1)tecovirimat will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.tedizolidSerious - Use Alternative (1)tedizolid, trazodone. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. both increase serotonin levels; increased risk of serotonin syndrome.telavancinMonitor Closely (1)trazodone and telavancin both increase QTc interval. Modify Therapy/Monitor Closely.temazepamMonitor Closely (1)temazepam and trazodone both increase sedation. Use Caution/Monitor.terbutalineMonitor Closely (1)trazodone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)trazodone, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.tetrabenazineSerious - Use Alternative (1)tetrabenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.thioridazineMonitor Closely (1)thioridazine and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)thioridazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)trazodone, thioridazine. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects. trazodone, thioridazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.thiothixeneMonitor Closely (1)thiothixene and trazodone both increase sedation. Use Caution/Monitor.tinidazoleMonitor Closely (1)trazodone will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tiotropiumMonitor Closely (1)tiotropium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.tipranavirSerious - Use Alternative (1)tipranavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.tobramycinMonitor Closely (1)trazodone will decrease the level or effect of tobramycin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.tolazamideMinor (1)trazodone increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown.tolbutamideMinor (1)trazodone increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown.tolfenamic acidMonitor Closely (1)trazodone, tolfenamic acid. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.tolmetinMonitor Closely (1)trazodone, tolmetin. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.tolterodineMonitor Closely (1)tolterodine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.tolvaptanMonitor Closely (1)trazodone will decrease the level or effect of tolvaptan by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.topiramateMonitor Closely (2)topiramate will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. trazodone and topiramate both increase sedation. Modify Therapy/Monitor Closely.toremifeneSerious - Use Alternative (1)trazodone and toremifene both increase QTc interval. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.torsemideMinor (1)torsemide, trazodone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Possible additive hyponatremia.tramadolMonitor Closely (2)trazodone and tramadol both increase serotonin levels. Modify Therapy/Monitor Closely. tramadol and trazodone both increase sedation. Use Caution/Monitor.tranylcypromineContraindicated (1)tranylcypromine and trazodone both increase serotonin levels. Contraindicated.triazolamMonitor Closely (1)triazolam and trazodone both increase sedation. Use Caution/Monitor.triclabendazoleMonitor Closely (1)triclabendazole and trazodone both increase QTc interval. Use Caution/Monitor.triclofosMonitor Closely (1)triclofos and trazodone both increase sedation. Use Caution/Monitor.trifluoperazineMonitor Closely (1)trifluoperazine and trazodone both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)trifluoperazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)trazodone, trifluoperazine. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects. trazodone, trifluoperazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.trimethoprimMonitor Closely (1)trazodone and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely.trimipramineMonitor Closely (2)trazodone and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. trazodone and trimipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)trazodone and trimipramine both increase QTc interval. Avoid or Use Alternate Drug. trazodone and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.triprolidineMonitor Closely