AdultPediatricDosage Forms & Strengths budesonide/formoterol/glycopyrrolate inhalation aerosol 160mcg/9mcg/4.8mcg per inhalation Chronic Obstructive Pulmonary Disease Indicated for maintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD) 2 oral inhalations BID Dosage Modifications Renal impairment Formal pharmacokinetic studies not conducted; however, glycopyrronium systemic exposure increased with moderate renal impairment (ie, eGFR 45 mL/min) Severe (CrCl ≤30 mL/min/1.73m2) or end-stage renal disease requiring dialysis: Use if expected benefit outweighs potential risk Hepatic impairment Formal pharmacokinetic studies not conducted; however, budesonide and formoterol fumarate are predominantly cleared by hepatic metabolism Severe hepatic disease: Closely monitor Dosing Considerations Limitations of use: Not indicated for relief of acute bronchospasm or treatment of asthmaSafety and efficacy not establishedInteraction CheckerEnter a drug name and budesonide inhaled/formoterol/glycopyrrolate inhaledNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (1)umeclidinium bromide/vilanterol inhaledglycopyrrolate inhaled, umeclidinium bromide/vilanterol inhaled. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated. Duplicate therapy.Serious - Use Alternative (68)adagrasibadagrasib, formoterol. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.amisulprideamisulpride and formoterol both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineamitriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amoxapineamoxapine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.amoxapine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.arformoterolarformoterol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineformoterol and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazinechlorpromazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinclarithromycin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clomipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.desipraminedesipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.desipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.disopyramidedisopyramide and formoterol both increase QTc interval. Avoid or Use Alternate Drug.dofetilidedofetilide and formoterol both increase QTc interval. Avoid or Use Alternate Drug.doxepindoxepin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.doxepin, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dronedaronedronedarone and formoterol both increase QTc interval. Avoid or Use Alternate Drug.droperidoldroperidol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.entrectinibformoterol and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.epinephrineepinephrine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicepinephrine racemic and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseerythromycin base and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateerythromycin ethylsuccinate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateerythromycin lactobionate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateerythromycin stearate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.fexinidazolefexinidazole and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fluconazolefluconazole and formoterol both increase QTc interval. Avoid or Use Alternate Drug.fluphenazinefluphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.glasdegibformoterol and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.glucagonglucagon increases toxicity of glycopyrrolate inhaled by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .glucagon intranasalglucagon intranasal increases toxicity of glycopyrrolate inhaled by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .haloperidolformoterol and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydroxychloroquine sulfatehydroxychloroquine sulfate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.ibutilideformoterol and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.imipramineimipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.imipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.indapamideformoterol and indapamide both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabinotuzumab and formoterol both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.isocarboxazidisocarboxazid increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.ivosidenibivosidenib and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazoleformoterol and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lefamulinlefamulin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.levoketoconazoleformoterol and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.linezolidlinezolid increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lofepraminelofepramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.lofepramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lonafarniblonafarnib will increase the level or effect of budesonide inhaled by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.lumefantrineformoterol and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinbudesonide inhaled, macimorelin. unspecified interaction mechanism. Avoid or Use Alternate Drug. Drugs that directly affect the pituitary secretion of growth hormone (GH) may impact the accuracy of the macimorelin diagnostic test. Allow sufficient washout time of drugs affecting GH growth hormone release before administering prior to administration of macimorelin. Drugs that directly affect the pituitary secretion of growth hormone (GH) may impact the accuracy of the macimorelin diagnostic test. Allow sufficient washout time of drugs affecting GH release before administering macimorelin.macimorelin and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilinemaprotiline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.maprotiline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.mobocertinibmobocertinib and formoterol both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinformoterol and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotinibformoterol and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.nortriptylinenortriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.nortriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.octreotideformoterol and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)formoterol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.ondansetronformoterol and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.panobinostatformoterol and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.pentamidineformoterol and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.perphenazineperphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.phenelzinephenelzine increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.pimozideformoterol and pimozide both increase QTc interval. Avoid or Use Alternate Drug.pitolisantformoterol and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.pramlintidepramlintide, glycopyrrolate inhaled. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.primaquineprimaquine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.procainamideformoterol and procainamide both increase QTc interval. Avoid or Use Alternate Drug.prochlorperazineprochlorperazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.promazinepromazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.promethazinepromethazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.protriptylineprotriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.protriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.quinidinequinidine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.revefenacinrevefenacin and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.sotalolformoterol and sotalol both increase QTc interval. Avoid or Use Alternate Drug. Drugs known to prolong the QTc interval may potentiate the cardiovascular effects of formoterol.sotalol and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Drugs known to prolong the QTc interval may potentiate the cardiovascular effects of formoterol.Monitor Closely (322)abobotulinumtoxinAabobotulinumtoxinA increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .acebutololacebutolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acebutolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.aceclofenacaceclofenac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinacemetacin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidiniumglycopyrrolate inhaled and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.albuterolalbuterol and formoterol both decrease serum potassium. Use Caution/Monitor.albuterol and formoterol both decrease sedation. Use Caution/Monitor.albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilalfentanil increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfuzosinformoterol and alfuzosin both increase QTc interval. Use Caution/Monitor.alfuzosin and formoterol both increase QTc interval. Use Caution/Monitor.alprazolamalprazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amantadineglycopyrrolate inhaled increases levels of amantadine by unknown mechanism. Use Caution/Monitor.glycopyrrolate inhaled, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amilorideamiloride increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amiodaroneamiodarone and formoterol both increase QTc interval. Use Caution/Monitor.amitriptylineamitriptyline increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor.glycopyrrolate inhaled and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.amitriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amobarbitalamobarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineglycopyrrolate inhaled and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor.amoxapineamoxapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.apomorphineapomorphine and formoterol both increase QTc interval. Use Caution/Monitor.arformoterolarformoterol and formoterol both decrease serum potassium. Use Caution/Monitor.arformoterol and formoterol both decrease sedation. Use Caution/Monitor.arformoterol and