and clofazimine both increase QTc interval. Avoid or Use Alternate Drug.clomipramineSerious - Use Alternative (1)hydroxychloroquine sulfate and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.clozapineSerious - Use Alternative (1)hydroxychloroquine sulfate and clozapine both increase QTc interval. Avoid or Use Alternate Drug.crizotinibSerious - Use Alternative (1)hydroxychloroquine sulfate and crizotinib both increase QTc interval. Avoid or Use Alternate Drug.cyclosporineMonitor Closely (1)hydroxychloroquine sulfate will increase the level or effect of cyclosporine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.dapsone topicalSerious - Use Alternative (1)hydroxychloroquine sulfate, dapsone topical. unspecified interaction mechanism. Avoid or Use Alternate Drug. Avoid coadministration of dapsone topical with oral dapsone or antimalarial medications because of the potential for hemolytic reactions.dasatinibSerious - Use Alternative (1)hydroxychloroquine sulfate and dasatinib both increase QTc interval. Avoid or Use Alternate Drug.degarelixSerious - Use Alternative (1)hydroxychloroquine sulfate and degarelix both increase QTc interval. Avoid or Use Alternate Drug.dengue vaccineMonitor Closely (1)hydroxychloroquine sulfate decreases effects of dengue vaccine by immunosuppressive effects; risk of infection. Use Caution/Monitor. Immunosuppressive therapies (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, corticosteroids [greater than physiologic doses]) may reduce immune response to dengue vaccine.denosumabMonitor Closely (1)hydroxychloroquine sulfate, denosumab. Other (see comment). Use Caution/Monitor. Comment: Caution should be taken in patients on concomitant immunosuppressants or with impaired immune systems because of increased risk for serious infections.desfluraneSerious - Use Alternative (1)desflurane and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.desipramineSerious - Use Alternative (1)hydroxychloroquine sulfate and desipramine both increase QTc interval. Avoid or Use Alternate Drug.deutetrabenazineMonitor Closely (1)hydroxychloroquine sulfate and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).digoxinSerious - Use Alternative (1)hydroxychloroquine sulfate increases levels of digoxin by unknown mechanism. Avoid or Use Alternate Drug.diphtheria & tetanus toxoidsSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of diphtheria & tetanus toxoids by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.diphtheria & tetanus toxoids/ acellular pertussis vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of diphtheria & tetanus toxoids/ acellular pertussis vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.diphtheria & tetanus toxoids/acellular pertussis/poliovirus, inactivated vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of diphtheria & tetanus toxoids/acellular pertussis/poliovirus, inactivated vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.disopyramideSerious - Use Alternative (1)hydroxychloroquine sulfate and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dofetilideSerious - Use Alternative (2)hydroxychloroquine sulfate and dofetilide both increase QTc interval. Avoid or Use Alternate Drug. dofetilide increases toxicity of hydroxychloroquine sulfate by QTc interval. Avoid or Use Alternate Drug.dolasetronSerious - Use Alternative (1)hydroxychloroquine sulfate and dolasetron both increase QTc interval. Avoid or Use Alternate Drug.donepezilSerious - Use Alternative (1)donepezil and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.doxepinSerious - Use Alternative (1)doxepin and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.dronedaroneSerious - Use Alternative (1)hydroxychloroquine sulfate and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolSerious - Use Alternative (1)hydroxychloroquine sulfate and droperidol both increase QTc interval. Avoid or Use Alternate Drug.echinaceaMonitor Closely (1)hydroxychloroquine sulfate increases and echinacea decreases immunosuppressive effects; risk of infection. Effect of interaction is not clear, use caution. Use Caution/Monitor.efavirenzSerious - Use Alternative (1)efavirenz and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.eliglustatSerious - Use Alternative (1)eliglustat and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.encorafenibSerious - Use Alternative (2)encorafenib and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug. Encorafenib is associated with dose-dependent QTc interval prolongation. Avoid with drugs known to prolong QT interval. hydroxychloroquine sulfate and encorafenib both increase QTc interval. Avoid or Use Alternate Drug.entrectinibSerious - Use Alternative (1)hydroxychloroquine sulfate and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.eribulinSerious - Use Alternative (1)hydroxychloroquine sulfate and eribulin both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseSerious - Use Alternative (1)hydroxychloroquine sulfate and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)hydroxychloroquine sulfate and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)hydroxychloroquine sulfate and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)hydroxychloroquine sulfate and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramSerious - Use Alternative (2)hydroxychloroquine sulfate and escitalopram both increase QTc interval. Avoid or Use Alternate Drug. escitalopram increases toxicity of hydroxychloroquine sulfate by QTc interval. Avoid or Use Alternate Drug.etanerceptSerious - Use Alternative (1)etanercept and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.everolimusSerious - Use Alternative (1)everolimus and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.ezogabineSerious - Use Alternative (1)hydroxychloroquine sulfate and ezogabine both increase QTc interval. Avoid or Use Alternate Drug.fexinidazoleSerious - Use Alternative (1)fexinidazole and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.fingolimodSerious - Use Alternative (1)fingolimod and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.flecainideSerious - Use Alternative (1)hydroxychloroquine sulfate and flecainide both increase QTc interval. Avoid or Use Alternate Drug.fluconazoleSerious - Use Alternative (1)hydroxychloroquine sulfate and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetineSerious - Use Alternative (1)hydroxychloroquine sulfate and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.fluphenazineSerious - Use Alternative (1)hydroxychloroquine sulfate and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.formoterolSerious - Use Alternative (1)hydroxychloroquine sulfate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.foscarnetSerious - Use Alternative (1)hydroxychloroquine sulfate and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.fostemsavirMonitor Closely (1)hydroxychloroquine sulfate and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. gemifloxacinSerious - Use Alternative (1)hydroxychloroquine sulfate and gemifloxacin both increase QTc interval. Avoid or Use Alternate Drug.gemtuzumabSerious - Use Alternative (1)hydroxychloroquine sulfate and gemtuzumab both increase QTc interval. Avoid or Use Alternate Drug.gilteritinibSerious - Use Alternative (1)gilteritinib and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.glasdegibSerious - Use Alternative (1)hydroxychloroquine sulfate and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.glatiramerSerious - Use Alternative (1)glatiramer and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.golimumabSerious - Use Alternative (1)golimumab and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.granisetronSerious - Use Alternative (1)granisetron and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.haloperidolSerious - Use Alternative (1)hydroxychloroquine sulfate and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hepatitis A vaccine inactivatedSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of hepatitis A vaccine inactivated by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.hepatitis a/b vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of hepatitis a/b vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.hepatitis a/typhoid vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of hepatitis a/typhoid vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.hepatitis b vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of hepatitis b vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.human papillomavirus vaccine, nonavalentSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of human papillomavirus vaccine, nonavalent by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs, and corticosteroids (used in greater than physiologic doses), may reduce the immune responses to vaccines.human papillomavirus vaccine, quadrivalentSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of human papillomavirus vaccine, quadrivalent by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs, and corticosteroids (used in greater than physiologic doses), may reduce the immune responses to vaccines.hydroxyzineSerious - Use Alternative (1)hydroxyzine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.ibutilideSerious - Use Alternative (1)hydroxychloroquine sulfate and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.idecabtagene vicleucelSerious - Use Alternative (1)hydroxychloroquine sulfate, idecabtagene vicleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.iloperidoneSerious - Use Alternative (1)hydroxychloroquine sulfate and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.indacaterol, inhaledSerious - Use Alternative (1)hydroxychloroquine sulfate and indacaterol, inhaled both increase QTc interval. Avoid or Use Alternate Drug.indapamideSerious - Use Alternative (1)hydroxychloroquine sulfate and indapamide both increase QTc interval. Avoid or Use Alternate Drug.infliximabSerious - Use Alternative (1)hydroxychloroquine sulfate and infliximab both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.influenza virus vaccine quadrivalent, cell-culturedSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of influenza virus vaccine quadrivalent, cell-cultured by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.influenza virus vaccine quadrivalent, intranasalSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of influenza virus vaccine quadrivalent, intranasal by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.influenza virus vaccine trivalentSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of influenza virus vaccine trivalent by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.influenza virus vaccine trivalent, recombinantMonitor Closely (1)hydroxychloroquine sulfate decreases effects of influenza virus vaccine trivalent, recombinant by pharmacodynamic antagonism. Use Caution/Monitor. Immune response to vaccine may be decreased in immunocompromised individuals.inotuzumabSerious - Use Alternative (1)hydroxychloroquine sulfate and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.isavuconazonium sulfateMonitor Closely (1)hydroxychloroquine sulfate and isavuconazonium sulfate both decrease immunosuppressive effects; risk of infection. Use Caution/Monitor.isofluraneSerious - Use Alternative (1)isoflurane and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.isradipineSerious - Use Alternative (1)hydroxychloroquine sulfate and isradipine both increase QTc interval. Avoid or Use Alternate Drug.itraconazoleSerious - Use Alternative (1)itraconazole and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.Japanese encephalitis virus vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of Japanese encephalitis virus vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.lapatinibSerious - Use Alternative (1)hydroxychloroquine sulfate and lapatinib both increase QTc interval. Avoid or Use Alternate Drug.lefamulinContraindicated (1)lefamulin will increase the level or effect of hydroxychloroquine sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.leflunomideSerious - Use Alternative (1)hydroxychloroquine sulfate and leflunomide both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.levofloxacinSerious - Use Alternative (1)hydroxychloroquine sulfate and levofloxacin both increase QTc interval. Avoid or Use Alternate Drug.lisocabtagene maraleucelSerious - Use Alternative (1)hydroxychloroquine sulfate, lisocabtagene maraleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.lithiumSerious - Use Alternative (1)lithium and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.lofexidineSerious - Use Alternative (1)hydroxychloroquine sulfate and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.lopinavirSerious - Use Alternative (1)hydroxychloroquine sulfate and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.maitakeMonitor Closely (1)hydroxychloroquine sulfate increases and maitake decreases immunosuppressive effects; risk of infection. Effect of interaction is not clear, use caution. Use Caution/Monitor.maprotilineSerious - Use Alternative (1)hydroxychloroquine sulfate and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.measles (rubeola) vaccineSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of measles (rubeola) vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.measles mumps and rubella vaccine, liveSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of measles mumps and rubella vaccine, live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.measles, mumps, rubella and varicella vaccine, liveSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of measles, mumps, rubella and varicella vaccine, live by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.mefloquineSerious - Use Alternative (1)hydroxychloroquine sulfate and mefloquine both increase QTc interval. Avoid or Use Alternate Drug.meningococcal A C Y and W-135 polysaccharide vaccine combinedSerious - Use Alternative (1)hydroxychloroquine sulfate decreases effects of meningococcal A C Y and W-135 polysaccharide vaccine combined by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines.mercaptopurineMonitor Closely (1)hydroxychloroquine sulfate and mercaptopurine both increase immunosuppressive effects;