have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.levalbuteroltemazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levonorgestrel oral/ethinylestradiol/ferrous bisglycinatelevonorgestrel oral/ethinylestradiol/ferrous bisglycinate will decrease the level or effect of temazepam by unknown mechanism. Use Caution/Monitor.levorphanoltemazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetaminetemazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepraminetemazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidinetemazepam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamloprazolam and temazepam both increase sedation. Use Caution/Monitor.lorazepamlorazepam and temazepam both increase sedation. Use Caution/Monitor.lormetazepamlormetazepam and temazepam both increase sedation. Use Caution/Monitor.loxapinetemazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledtemazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.maprotilinetemazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanatemazepam and marijuana both increase sedation. Use Caution/Monitor.melatonintemazepam and melatonin both increase sedation. Use Caution/Monitor.meperidinetemazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamatetemazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenoltemazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonetemazepam and metaxalone both increase sedation. Use Caution/Monitor.methadonetemazepam and methadone both increase sedation. Use Caution/Monitor.methamphetaminetemazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamoltemazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminetemazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and temazepam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinetemazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapinetemazepam and mirtazapine both increase sedation. Use Caution/Monitor.modafiniltemazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinetemazepam and morphine both increase sedation. Use Caution/Monitor.motherworttemazepam and motherwort both increase sedation. Use Caution/Monitor.moxonidinetemazepam and moxonidine both increase sedation. Use Caution/Monitor.nabilonetemazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphinetemazepam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrinetemazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinetemazepam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapinetemazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tincturetemazepam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrinetemazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamoxazepam and temazepam both increase sedation. Use Caution/Monitor.oxycodonetemazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonetemazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonetemazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumtemazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverinetemazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocinetemazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and temazepam both increase sedation. Use Caution/Monitor.perphenazinetemazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazinetemazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and temazepam both increase sedation. Use Caution/Monitor.phenterminetemazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinetemazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POtemazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinetemazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozidetemazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuteroltemazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinpregabalin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and temazepam both increase sedation. Use Caution/Monitor.prochlorperazinetemazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and temazepam both increase sedation. Use Caution/Monitor.propofolpropofol and temazepam both increase sedation. Use Caution/Monitor.propylhexedrinetemazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinetemazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamquazepam and temazepam both increase sedation. Use Caution/Monitor.quetiapinetemazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteontemazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, temazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.risperidonetemazepam and risperidone both increase sedation. Use Caution/Monitor.salmeteroltemazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcaptemazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and temazepam both increase sedation. Use Caution/Monitor.sevofluranesevoflurane and temazepam both increase sedation. Use Caution/Monitor.shepherd's pursetemazepam and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentaniltemazepam and sufentanil both increase sedation. Use Caution/Monitor.tapentadoltemazepam and tapentadol both increase sedation. Use Caution/Monitor.terbutalinetemazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazinetemazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixenetemazepam and thiothixene both increase sedation. Use Caution/Monitor.topiramatetemazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadoltemazepam and tramadol both increase sedation. Use Caution/Monitor.trazodonetemazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamtemazepam and triazolam both increase sedation. Use Caution/Monitor.triclofostemazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazinetemazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipraminetemazepam and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and temazepam both increase sedation. Use Caution/Monitor.xylometazolinetemazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinetemazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidetemazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidonetemazepam and ziprasidone both increase sedation. Use Caution/Monitor.zotepinetemazepam and zotepine both increase sedation. Use Caution/Monitor.Minor (13)brimonidinebrimonidine increases effects of temazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.ciprofloxacinciprofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.eucalyptustemazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fleroxacinfleroxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.green teagreen tea decreases effects of temazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.levofloxacinlevofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of temazepam by increasing metabolism. Minor/Significance Unknown.sagetemazepam and sage both increase sedation. Minor/Significance Unknown.vinpocetinetemazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).zolpidemzolpidem, temazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.acrivastineMonitor Closely (1)acrivastine and temazepam both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)temazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)temazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and temazepam both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and temazepam both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)temazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and temazepam both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)temazepam and amoxapine both increase sedation. Use Caution/Monitor.apomorphineMonitor Closely (1)temazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)temazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)temazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)temazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and temazepam both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and temazepam both increase sedation. Use Caution/Monitor.avapritinibMonitor Closely (1)avapritinib and temazepam both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and temazepam both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)temazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)temazepam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)temazepam and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)temazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, temazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and temazepam both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and temazepam both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of temazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and temazepam both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and temazepam both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)temazepam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)temazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)temazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.Serious - Use Alternative (1)buprenorphine subdermal implant and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionMonitor Closely (1)temazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.Serious - Use Alternative (1)buprenorphine, long-acting injection and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)butabarbital and temazepam both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and temazepam both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)temazepam and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)temazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesContraindicated (1)temazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.carbinoxamineMonitor Closely (1)carbinoxamine and temazepam both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)temazepam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateMonitor Closely (1)temazepam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and temazepam both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)temazepam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)temazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and temazepam both increase sedation. Use Caution/Monitor.ciprofloxacinMinor (1)ciprofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.clemastineMonitor Closely (1)clemastine and temazepam both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)temazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)temazepam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and temazepam both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateMonitor Closely (1)clorazepate and temazepam both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)temazepam and clozapine