and maprotiline both increase sedation. Use Caution/Monitor.marijuanadoxylamine and marijuana both increase sedation. Use Caution/Monitor.melatonindoxylamine and melatonin both increase sedation. Use Caution/Monitor.meperidinedoxylamine and meperidine both increase sedation. Use Caution/Monitor.meprobamatedoxylamine and meprobamate both increase sedation. Use Caution/Monitor.metaxalonedoxylamine and metaxalone both increase sedation. Use Caution/Monitor.methadonedoxylamine and methadone both increase sedation. Use Caution/Monitor.methocarbamoldoxylamine and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminedoxylamine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and doxylamine both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.mirtazapinedoxylamine and mirtazapine both increase sedation. Use Caution/Monitor.morphinedoxylamine and morphine both increase sedation. Use Caution/Monitor.motherwortdoxylamine and motherwort both increase sedation. Use Caution/Monitor.moxonidinedoxylamine and moxonidine both increase sedation. Use Caution/Monitor.nabilonedoxylamine and nabilone both increase sedation. Use Caution/Monitor.nalbuphinedoxylamine and nalbuphine both increase sedation. Use Caution/Monitor.nortriptylinedoxylamine and nortriptyline both increase sedation. Use Caution/Monitor.olanzapinedoxylamine and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tincturedoxylamine and opium tincture both increase sedation. Use Caution/Monitor.orphenadrinedoxylamine and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamoxazepam and doxylamine both increase sedation. Use Caution/Monitor.oxycodonedoxylamine and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonedoxylamine and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonedoxylamine and paliperidone both increase sedation. Use Caution/Monitor.papaveretumdoxylamine and papaveretum both increase sedation. Use Caution/Monitor.papaverinedoxylamine and papaverine both increase sedation. Use Caution/Monitor.passion flowerpassion flower increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.pentazocinedoxylamine and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and doxylamine both increase sedation. Use Caution/Monitor.perphenazinedoxylamine and perphenazine both increase sedation. Use Caution/Monitor.phenelzinephenelzine increases effects of doxylamine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .phenobarbitalphenobarbital and doxylamine both increase sedation. Use Caution/Monitor.phenylephrine POdoxylamine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinedoxylamine and pholcodine both increase sedation. Use Caution/Monitor.pimozidedoxylamine and pimozide both increase sedation. Use Caution/Monitor.pregabalinpregabalin, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and doxylamine both increase sedation. Use Caution/Monitor.prochlorperazinedoxylamine and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and doxylamine both increase sedation. Use Caution/Monitor.propofolpropofol and doxylamine both increase sedation. Use Caution/Monitor.propylhexedrinedoxylamine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinedoxylamine and protriptyline both increase sedation. Use Caution/Monitor.quazepamquazepam and doxylamine both increase sedation. Use Caution/Monitor.quetiapinedoxylamine and quetiapine both increase sedation. Use Caution/Monitor.ramelteondoxylamine and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, doxylamine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.risperidonedoxylamine and risperidone both increase sedation. Use Caution/Monitor.scullcapdoxylamine and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and doxylamine both increase sedation. Use Caution/Monitor.sevofluranesevoflurane and doxylamine both increase sedation. Use Caution/Monitor.shepherd's pursedoxylamine and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, doxylamine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanildoxylamine and sufentanil both increase sedation. Use Caution/Monitor.tapentadoldoxylamine and tapentadol both increase sedation. Use Caution/Monitor.temazepamtemazepam and doxylamine both increase sedation. Use Caution/Monitor.thioridazinedoxylamine and thioridazine both increase sedation. Use Caution/Monitor.thiothixenedoxylamine and thiothixene both increase sedation. Use Caution/Monitor.topiramatedoxylamine and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadoldoxylamine and tramadol both increase sedation. Use Caution/Monitor.trazodonedoxylamine and trazodone both increase sedation. Use Caution/Monitor.triazolamtriazolam and doxylamine both increase sedation. Use Caution/Monitor.triclofosdoxylamine and triclofos both increase sedation. Use Caution/Monitor.trifluoperazinedoxylamine and trifluoperazine both increase sedation. Use Caution/Monitor.trimipraminedoxylamine and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and doxylamine both increase sedation. Use Caution/Monitor.valerianvalerian increases effects of doxylamine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.xylometazolinedoxylamine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidedoxylamine and ziconotide both increase sedation. Use Caution/Monitor.ziprasidonedoxylamine and ziprasidone both increase sedation. Use Caution/Monitor.zotepinedoxylamine and zotepine both increase sedation. Use Caution/Monitor.Minor (6)ashwagandhaashwagandha increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.brimonidinebrimonidine increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.eucalyptusdoxylamine and eucalyptus both increase sedation. Minor/Significance Unknown.nettlenettle increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.sagedoxylamine and sage both increase sedation. Minor/Significance Unknown.Siberian ginsengSiberian ginseng increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.acrivastineMonitor Closely (1)acrivastine and doxylamine both increase sedation. Use Caution/Monitor.alfentanilMonitor Closely (1)doxylamine and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and doxylamine both increase sedation. Use Caution/Monitor.amifampridineMonitor Closely (1)doxylamine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.amisulprideMonitor Closely (1)amisulpride and doxylamine both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)doxylamine and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and doxylamine both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)doxylamine and amoxapine both increase sedation. Use Caution/Monitor.apomorphineMonitor Closely (1)doxylamine and apomorphine both increase sedation. Use Caution/Monitor.aripiprazoleMonitor Closely (1)doxylamine and aripiprazole both increase sedation. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and doxylamine both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and doxylamine both increase sedation. Use Caution/Monitor.ashwagandhaMinor (1)ashwagandha increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.avapritinibMonitor Closely (1)avapritinib and doxylamine both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and doxylamine both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)doxylamine and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)doxylamine and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)doxylamine and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenMonitor Closely (1)benzhydrocodone/acetaminophen and doxylamine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)benzhydrocodone/acetaminophen, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzphetamineMonitor Closely (1)doxylamine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, doxylamine. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and doxylamine both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and doxylamine both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and doxylamine both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and doxylamine both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)doxylamine and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)doxylamine and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)buprenorphine subdermal implant and doxylamine both increase sedation. Use Caution/Monitor.buprenorphine transdermalMonitor Closely (1)buprenorphine transdermal and doxylamine both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionMonitor Closely (2)buprenorphine, long-acting injection and doxylamine both increase sedation. Use Caution/Monitor. doxylamine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.butabarbitalMonitor Closely (1)butabarbital and doxylamine both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and doxylamine both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)doxylamine and butorphanol both increase sedation. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)doxylamine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carbinoxamineMonitor Closely (1)carbinoxamine and doxylamine both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)doxylamine and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, doxylamine. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateMonitor Closely (1)chloral hydrate and doxylamine both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and doxylamine both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)doxylamine and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)doxylamine and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and doxylamine both increase sedation. Use Caution/Monitor.clemastineMonitor Closely (1)clemastine and doxylamine both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)doxylamine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)doxylamine and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and doxylamine both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, doxylamine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateMonitor Closely (1)clorazepate and doxylamine both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)doxylamine and clozapine both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)doxylamine and codeine both increase sedation. Use Caution/Monitor.cyclizineMonitor Closely (1)cyclizine and doxylamine both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)doxylamine and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and doxylamine both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)doxylamine and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)doxylamine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desipramineMonitor Closely (1)doxylamine and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)doxylamine and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and doxylamine both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)doxylamine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine and doxylamine both increase sedation. Use Caution/Monitor.dextromoramideMonitor Closely (1)doxylamine and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)doxylamine and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and doxylamine both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.difelikefalinMonitor Closely (1)difelikefalin and doxylamine both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)doxylamine and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and doxylamine both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and doxylamine both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)doxylamine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)doxylamine and dipipanone both increase sedation. Use Caution/Monitor.dopexamineMonitor Closely (1)doxylamine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)doxylamine and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)doxylamine and doxepin both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)doxylamine and droperidol both increase sedation. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)esketamine intranasal, doxylamine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamMonitor Closely (1)estazolam and doxylamine both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (1)doxylamine and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and doxylamine both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)doxylamine and eucalyptus both increase sedation. Minor/Significance Unknown.fenfluramineMonitor Closely (1)doxylamine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fentanylSerious - Use Alternative (1)fentanyl, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalSerious - Use Alternative (1)fentanyl intranasal, doxylamine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious