Unknown. Hypokalemia.noni juicenoni juice increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.prochlorperazineprochlorperazine increases toxicity of glycopyrrolate inhaled by unknown mechanism. Minor/Significance Unknown.promazinepromazine increases toxicity of glycopyrrolate inhaled by unknown mechanism. Minor/Significance Unknown.promethazinepromethazine increases toxicity of glycopyrrolate inhaled by unknown mechanism. Minor/Significance Unknown.rimantadinerimantadine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Minor/Significance Unknown.sagesage increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.thioridazinethioridazine increases toxicity of glycopyrrolate inhaled by unknown mechanism. Minor/Significance Unknown.torsemideformoterol, torsemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.trazodoneglycopyrrolate inhaled and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.trazodone increases levels of glycopyrrolate inhaled by unknown mechanism. Minor/Significance Unknown.abobotulinumtoxinAMonitor Closely (1)abobotulinumtoxinA increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .acebutololMonitor Closely (2)acebutolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. acebutolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aceclofenacMonitor Closely (1)aceclofenac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinMonitor Closely (1)acemetacin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidiniumMonitor Closely (1)glycopyrrolate inhaled and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.adagrasibSerious - Use Alternative (1)adagrasib, formoterol. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolMonitor Closely (3)albuterol and formoterol both decrease serum potassium. Use Caution/Monitor. albuterol and formoterol both decrease sedation. Use Caution/Monitor. albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfuzosinMonitor Closely (2)formoterol and alfuzosin both increase QTc interval. Use Caution/Monitor. alfuzosin and formoterol both increase QTc interval. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amantadineMonitor Closely (2)glycopyrrolate inhaled increases levels of amantadine by unknown mechanism. Use Caution/Monitor. glycopyrrolate inhaled, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amilorideMonitor Closely (1)amiloride increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amiodaroneMonitor Closely (1)amiodarone and formoterol both increase QTc interval. Use Caution/Monitor.amisulprideSerious - Use Alternative (1)amisulpride and formoterol both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineMonitor Closely (3)amitriptyline increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor. amitriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. glycopyrrolate inhaled and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)amitriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. amitriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.amobarbitalMonitor Closely (1)amobarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineMonitor Closely (3)glycopyrrolate inhaled and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. amoxapine increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor. amoxapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. amoxapine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.anticholinergic/sedative combosMonitor Closely (1)anticholinergic/sedative combos and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.apomorphineMonitor Closely (1)apomorphine and formoterol both increase QTc interval. Use Caution/Monitor.arformoterolMonitor Closely (3)arformoterol and formoterol both decrease serum potassium. Use Caution/Monitor. arformoterol and formoterol both decrease sedation. Use Caution/Monitor. arformoterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (1)arformoterol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.aripiprazoleMonitor Closely (5)glycopyrrolate inhaled decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor. aripiprazole and formoterol both increase QTc interval. Use Caution/Monitor. glycopyrrolate inhaled decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. aripiprazole increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. aripiprazole increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilMonitor Closely (1)formoterol and armodafinil both decrease sedation. Use Caution/Monitor.arsenic trioxideMonitor Closely (1)arsenic trioxide and formoterol both increase QTc interval. Use Caution/Monitor.artemetherMonitor Closely (1)artemether and formoterol both increase QTc interval. Use Caution/Monitor.artemether/lumefantrineSerious - Use Alternative (1)formoterol and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalMonitor Closely (1)asenapine transdermal and formoterol both increase QTc interval. Use Caution/Monitor.aspirinMonitor Closely (1)aspirin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aspirin rectalMonitor Closely (1)aspirin rectal increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .aspirin/citric acid/sodium bicarbonateMonitor Closely (1)aspirin/citric acid/sodium bicarbonate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atenololMonitor Closely (3)atenolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. glycopyrrolate inhaled increases levels of atenolol by unknown mechanism. Use Caution/Monitor. atenolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.atomoxetineMonitor Closely (2)atomoxetine and formoterol both increase QTc interval. Use Caution/Monitor. formoterol, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .atracuriumMonitor Closely (1)atracurium and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineMonitor Closely (1)atropine and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMMonitor Closely (1)atropine IV/IM and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.azithromycinMonitor Closely (1)azithromycin and formoterol both increase QTc interval. Use Caution/Monitor.bedaquilineMonitor Closely (1)formoterol and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsMonitor Closely (1)belladonna alkaloids and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumMonitor Closely (2)glycopyrrolate inhaled and belladonna and opium both decrease cholinergic effects/transmission. Use Caution/Monitor. belladonna and opium increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bendroflumethiazideMonitor Closely (1)formoterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.benperidolMonitor Closely (4)glycopyrrolate inhaled decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor. glycopyrrolate inhaled decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. benperidol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. benperidol increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benzphetamineMonitor Closely (2)formoterol and benzphetamine both decrease sedation. Use Caution/Monitor. formoterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.benztropineMonitor Closely (1)benztropine and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.betaxololMonitor Closely (2)betaxolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. betaxolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.bethanecholMonitor Closely (1)bethanechol increases and glycopyrrolate inhaled decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.bisoprololMonitor Closely (2)bisoprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. bisoprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bumetanideMonitor Closely (1)formoterol and bumetanide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.buprenorphine buccalMonitor Closely (1)buprenorphine buccal increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butabarbitalMonitor Closely (1)butabarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.caffeineMonitor Closely (1)formoterol and caffeine both decrease sedation. Use Caution/Monitor.carbacholMonitor Closely (1)carbachol increases and glycopyrrolate inhaled decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbenoxoloneMonitor Closely (1)formoterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.carbinoxamineMonitor Closely (1)carbinoxamine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carvedilolMonitor Closely (2)carvedilol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. carvedilol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celecoxibMonitor Closely (1)celecoxib increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.celiprololMonitor Closely (2)celiprolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. celiprolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ceritinibMonitor Closely (1)ceritinib and formoterol both increase QTc interval. Use Caution/Monitor.cevimelineMonitor Closely (1)cevimeline increases and glycopyrrolate inhaled decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydrateMonitor Closely (1)chloral hydrate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloroquineMinor (1)chloroquine increases toxicity of formoterol by QTc interval. Minor/Significance Unknown.chlorothiazideMonitor Closely (1)formoterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chlorpheniramineMonitor Closely (1)chlorpheniramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazineMonitor Closely (5)glycopyrrolate inhaled decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. chlorpromazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. chlorpromazine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. chlorpromazine increases toxicity of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor. glycopyrrolate inhaled decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.chlorthalidoneMonitor Closely (1)formoterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.Minor (1)formoterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.choline magnesium trisalicylateMonitor Closely (1)choline magnesium trisalicylate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .cinnarizineMonitor Closely (1)cinnarizine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cisatracuriumMonitor Closely (1)cisatracurium and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.clarithromycinSerious - Use Alternative (1)clarithromycin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clemastineMonitor Closely (1)clemastine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineMonitor Closely (3)clomipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. clomipramine increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor. glycopyrrolate inhaled and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. clomipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clonazepamMonitor Closely (1)clonazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clorazepateMonitor Closely (1)clorazepate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineMonitor Closely (4)glycopyrrolate inhaled decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor. glycopyrrolate inhaled decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. clozapine increases effects of glycopyrrolate inhaled by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. clozapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cobicistatMonitor Closely (1)cobicistat increases levels of budesonide inhaled by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.codeineMonitor Closely (1)codeine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclizineMonitor Closely (2)cyclizine increases and formoterol decreases sedation. Effect of interaction