AdultPediatricGeriatricDosage Forms & Strengths tablet 25mg 50mg 75mg Depression Outpatient (Mild to Moderate Depression) Initial 75 mg PO qDay for 2 weeks Increase by 25 mg increments to effective dosage; not to exceed 150 mg/day Maintenance: Decrease dose to 75-150 mg PO qDay once symptoms are controlled Geriatric: 50-75 mg PO qDay Inpatient (Severe Depression) Initial 100-150 mg PO qDay for 2 weeks Increase cautiously to effective dosage; not to exceed 225 mg/day Geriatric: 50-75 mg PO qDay Other Indications & Uses Off-label: anxiety associated with depressionSafety and effecay not establishedInitial dose: 25 mg PO at bedtime, if tolerated increase by 25 mg every 3 days for inpatients and weekly for outpatients. Maintenance dose: 50-75 mg/day, may increase dose for nonresponders.Interaction CheckerEnter a drug name and maprotilineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (14)disopyramidemaprotiline and disopyramide both increase QTc interval. Contraindicated.ibutilidemaprotiline and ibutilide both increase QTc interval. Contraindicated.indapamidemaprotiline and indapamide both increase QTc interval. Contraindicated.iobenguane I 123maprotiline decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Contraindicated. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results.isocarboxazidisocarboxazid and maprotiline both increase serotonin levels. Contraindicated.pentamidinemaprotiline and pentamidine both increase QTc interval. Contraindicated.phenelzinephenelzine and maprotiline both increase serotonin levels. Contraindicated.pimozidemaprotiline and pimozide both increase QTc interval. Contraindicated.procainamidemaprotiline and procainamide both increase QTc interval. Contraindicated.procarbazineprocarbazine and maprotiline both increase serotonin levels. Contraindicated. Combination is contraindicated within 2 weeks of MAOI use.quinidinequinidine and maprotiline both increase QTc interval. Contraindicated.safinamidemaprotiline, safinamide. Either increases toxicity of the other by serotonin levels. Contraindicated. Concomitant use could result in life-threatening serotonin syndrome.sotalolmaprotiline and sotalol both increase QTc interval. Contraindicated.tranylcyprominetranylcypromine and maprotiline both increase serotonin levels. Contraindicated.Serious - Use Alternative (147)adagrasibadagrasib, maprotiline. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolmaprotiline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amiodaronemaprotiline and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulpridemaprotiline and amisulpride both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineamitriptyline and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.amoxapineamoxapine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.amoxapine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.anagrelideanagrelide and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.apomorphineapomorphine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.arformoterolmaprotiline, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.aripiprazolearipiprazole and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxidemaprotiline and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinemaprotiline and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapineasenapine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen and maprotiline both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetaminemaprotiline, benzphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.buprenorphine subdermal implantbuprenorphine subdermal implant and maprotiline both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalbuprenorphine transdermal and maprotiline both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionbuprenorphine, long-acting injection and maprotiline both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuspironemaprotiline and buspirone both increase serotonin levels. Avoid or Use Alternate Drug.calcium/magnesium/potassium/sodium oxybatesmaprotiline, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.ceritinibceritinib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazinechlorpromazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinmaprotiline and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.clomipramine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.clonidinemaprotiline decreases effects of clonidine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.clozapineclozapine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.dacomitinibdacomitinib will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. desfluranedesflurane and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.desipraminedesipramine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.desipramine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.desvenlafaxinemaprotiline and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.dexfenfluraminemaprotiline, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexmethylphenidatemaprotiline, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextroamphetaminemaprotiline, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextromethorphanmaprotiline and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.diethylpropionmaprotiline, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dobutaminemaprotiline, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilidemaprotiline and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dofetilide increases toxicity of maprotiline by QTc interval. Avoid or Use Alternate Drug.dopaminemaprotiline, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexaminemaprotiline, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.doxepindoxepin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.doxepin and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.dronedaronemaprotiline and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolmaprotiline and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineduloxetine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.eliglustateliglustat and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.encorafenibencorafenib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.entrectinibentrectinib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.ephedrinemaprotiline, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineepinephrine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.maprotiline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine racemicepinephrine racemic and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.maprotiline, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.eribulineribulin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.erythromycin basemaprotiline and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatemaprotiline and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatemaprotiline and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatemaprotiline and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramescitalopram and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.fenfluraminemaprotiline, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fluconazolemaprotiline and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.fluphenazinefluphenazine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.fluvoxaminefluvoxamine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.formoterolmaprotiline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.maprotiline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fosamprenavirfosamprenavir increases levels of maprotiline by decreasing metabolism. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.guanfacinemaprotiline decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.haloperidolmaprotiline and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydroxychloroquine sulfatehydroxychloroquine sulfate and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.imipramineimipramine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.imipramine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.isofluraneisoflurane and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.isoproterenolmaprotiline, isoproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.itraconazolemaprotiline and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazolemaprotiline and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levalbuterolmaprotiline, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.levoketoconazolemaprotiline and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranlevomilnacipran and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.linezolidlinezolid and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.lisdexamfetaminemaprotiline, lisdexamfetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lithiumlithium and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.lofepraminelofepramine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.lofepramine and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.lumefantrinemaprotiline and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration