amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. Additive anticholinergic adverse effects may be seen with concurrent use. bosentanbosentan will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.bethanecholbethanechol increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.brexanolonebrexanolone, chlordiazepoxide. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and amitriptyline both increase sedation. Use Caution/Monitor.brexpiprazole and chlordiazepoxide both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and amitriptyline both increase sedation. Use Caution/Monitor.brimonidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and amitriptyline both increase sedation. Use Caution/Monitor.brivaracetam and chlordiazepoxide both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and amitriptyline both increase sedation. Use Caution/Monitor.brompheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalchlordiazepoxide and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine buccal and amitriptyline both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantchlordiazepoxide increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.amitriptyline, buprenorphine subdermal implant. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine, long-acting injectionchlordiazepoxide increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.amitriptyline, buprenorphine, long-acting injection. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.bupropionamitriptyline increases toxicity of bupropion by unspecified interaction mechanism. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible.bupropion will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.butabarbitalbutabarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.butabarbitalbutabarbital will decrease the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.butabarbital will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.butabarbital and amitriptyline both increase sedation. Use Caution/Monitor.butalbitalbutalbital will decrease the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.butalbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.butalbital will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.butalbital and amitriptyline both increase sedation. Use Caution/Monitor.butorphanolchlordiazepoxide and butorphanol both increase sedation. Use Caution/Monitor.butorphanol and amitriptyline both increase sedation. Use Caution/Monitor.caffeineamitriptyline increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbacholcarbachol increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.carbamazepinecarbamazepine will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.carbamazepinecarbamazepine will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.carbinoxaminecarbinoxamine and chlordiazepoxide both increase sedation. Use Caution/Monitor.carbinoxamine and amitriptyline both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and carisoprodol both increase sedation. Use Caution/Monitor.cenobamatecenobamate, amitriptyline. Either increases effects of the other by sedation. Use Caution/Monitor.cenobamate, chlordiazepoxide. Either increases effects of the other by sedation. Use Caution/Monitor.ceritinibceritinib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ceritinib and amitriptyline both increase QTc interval. Use Caution/Monitor.cevimelinecevimeline increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.chloral hydratechlordiazepoxide and chloral hydrate both increase sedation. Use Caution/Monitor.chloral hydratechloral hydrate and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and amitriptyline both increase sedation. Use Caution/Monitor.chloroquinechloroquine increases toxicity of amitriptyline by QTc interval. Use Caution/Monitor.chlorpheniraminechlorpheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.chlorpheniramine and amitriptyline both increase sedation. Use Caution/Monitor.chlorpromazinechlordiazepoxide and chlorpromazine both increase sedation. Use Caution/Monitor.chlorpromazine and amitriptyline both increase sedation. Use Caution/Monitor.chlorzoxazonechlordiazepoxide and chlorzoxazone both increase sedation. Use Caution/Monitor.chlorzoxazone and amitriptyline both increase sedation. Use Caution/Monitor.cimetidinecimetidine will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.cimetidine increases levels of chlordiazepoxide by decreasing metabolism. Use Caution/Monitor.cinnarizinecinnarizine and chlordiazepoxide both increase sedation. Use Caution/Monitor.cinnarizine and amitriptyline both increase sedation. Use Caution/Monitor.cisatracuriumcisatracurium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.clarithromycinclarithromycin will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.clarithromycinclarithromycin will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.clemastineclemastine and amitriptyline both increase sedation. Use Caution/Monitor.clemastine and chlordiazepoxide both increase sedation. Use Caution/Monitor.clobazamamitriptyline, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).chlordiazepoxide, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clobazam will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. clomipramineamitriptyline and clomipramine both increase sedation. Use Caution/Monitor.chlordiazepoxide and clomipramine both increase sedation. Use Caution/Monitor.amitriptyline and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.clonazepamchlordiazepoxide and clonazepam both increase sedation. Use Caution/Monitor.clonazepam and amitriptyline both increase sedation. Use Caution/Monitor.clonidineclonidine, chlordiazepoxide. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateclorazepate and amitriptyline both increase sedation. Use Caution/Monitor.clorazepatechlordiazepoxide and clorazepate both increase sedation. Use Caution/Monitor.clotrimazoleclotrimazole will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.clozapinechlordiazepoxide and clozapine both increase sedation. Use Caution/Monitor.clozapine and amitriptyline both increase sedation. Use Caution/Monitor.clozapine and amitriptyline both increase QTc interval. Use Caution/Monitor.cobicistatcobicistat will increase the level or effect of amitriptyline by Other (see comment). Use Caution/Monitor. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. cobicistat will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.cobicistat will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Carefully titrate antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant responsecocaine topicalamitriptyline and cocaine topical both increase serotonin levels. Modify Therapy/Monitor Closely.codeinechlordiazepoxide and codeine both increase sedation. Use Caution/Monitor.codeinecodeine and amitriptyline both increase sedation. Use Caution/Monitor.conivaptanconivaptan will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.crizotinibcrizotinib and amitriptyline both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.crofelemercrofelemer increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.cyclizinecyclizine and amitriptyline both increase sedation. Use Caution/Monitor.cyclizine and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclizine and chlordiazepoxide both increase sedation. Use Caution/Monitor.cyclobenzaprinechlordiazepoxide and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyclobenzaprine and amitriptyline both increase sedation. Use Caution/Monitor.cyclosporinecyclosporine will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.cyclosporine will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.cyproheptadinecyproheptadine and chlordiazepoxide both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and amitriptyline both increase sedation. Use Caution/Monitor.dabrafenibdabrafenib will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.dantrolenechlordiazepoxide and dantrolene both increase sedation. Use Caution/Monitor.dantrolene and amitriptyline both increase sedation. Use Caution/Monitor.daridorexantchlordiazepoxide and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. amitriptyline and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darifenacindarifenacin will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.darifenacin and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.darunavirdarunavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.darunavirdarunavir will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration with SSRIs, TCAs, or trazodone may require dose titration of antidepressant to desired effect (eg, using the lowest feasible initial or maintenance dose). Monitor for antidepressant response.dasatinibamitriptyline and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.debrisoquineamitriptyline decreases effects of debrisoquine by Other (see comment). Use Caution/Monitor. Comment: Inhibition of uptake by adrenergic neurons.degarelixdegarelix and amitriptyline both increase QTc interval. Use Caution/Monitor.desfluranedesflurane and amitriptyline both increase sedation. Use Caution/Monitor.desflurane and chlordiazepoxide both increase sedation. Use Caution/Monitor.desflurane and amitriptyline both increase QTc interval. Use Caution/Monitor.desipramineamitriptyline and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.chlordiazepoxide and desipramine both increase sedation. Use Caution/Monitor.amitriptyline and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineamitriptyline and deutetrabenazine both increase sedation. Use Caution/Monitor.chlordiazepoxide and deutetrabenazine both increase sedation. Use Caution/Monitor.deutetrabenazine and amitriptyline both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniraminedexchlorpheniramine and amitriptyline both increase sedation. Use Caution/Monitor.dexchlorpheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.dexfenfluraminechlordiazepoxide increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline and dexfenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.amitriptyline increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinedexmedetomidine and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateamitriptyline increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineamitriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.chlordiazepoxide increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.dextroamphetamine transdermalamitriptyline will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Modify Therapy/Monitor Closely. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Monitor frequently and adjust or use an alternant based on clinical response.dextromoramidechlordiazepoxide and dextromoramide both increase sedation. Use Caution/Monitor.dextromoramidedextromoramide and amitriptyline both increase sedation. Use Caution/Monitor.diamorphinechlordiazepoxide and diamorphine both increase sedation. Use Caution/Monitor.diamorphine and amitriptyline both increase sedation. Use Caution/Monitor.diazepamdiazepam and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and diazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diazepam intranasal, amitriptyline. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.dicyclominedicyclomine and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.diethylpropionchlordiazepoxide increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diethylpropionamitriptyline increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and amitriptyline both increase sedation. Use Caution/Monitor.difelikefalin and chlordiazepoxide both increase sedation. Use Caution/Monitor.difenoxin hcldifenoxin hcl and amitriptyline both increase