both increase sedation. Use Caution/Monitor.prochlorperazineasenapine transdermal and prochlorperazine both decrease QTc interval. Use Caution/Monitor.asenapine transdermal and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineasenapine transdermal and promethazine both increase sedation. Use Caution/Monitor.propofolasenapine transdermal and propofol both increase sedation. Use Caution/Monitor.protriptylineasenapine transdermal and protriptyline both increase QTc interval. Use Caution/Monitor.asenapine transdermal and protriptyline both increase sedation. Use Caution/Monitor.pyrilamineasenapine transdermal and pyrilamine both increase sedation. Use Caution/Monitor.quazepamasenapine transdermal and quazepam both increase sedation. Use Caution/Monitor.quetiapineasenapine transdermal and quetiapine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and quetiapine both increase sedation. Use Caution/Monitor.ramelteonasenapine transdermal and ramelteon both increase sedation. Use Caution/Monitor.remifentanilasenapine transdermal and remifentanil both increase sedation. Use Caution/Monitor.remimazolamremimazolam, asenapine transdermal. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.reserpineasenapine transdermal and reserpine both increase sedation. Use Caution/Monitor.rilpivirineasenapine transdermal and rilpivirine both increase QTc interval. Use Caution/Monitor.risperidoneasenapine transdermal and risperidone both increase sedation. Use Caution/Monitor.scopolamineasenapine transdermal and scopolamine both increase sedation. Use Caution/Monitor.selpercatinibasenapine transdermal and selpercatinib both increase QTc interval. Use Caution/Monitor.sevofluraneasenapine transdermal and sevoflurane both increase sedation. Use Caution/Monitor.sodium oxybateasenapine transdermal and sodium oxybate both increase sedation. Use Caution/Monitor.sodium sulfate/?magnesium sulfate/potassium chloridesodium sulfate/?magnesium sulfate/potassium chloride increases effects of asenapine transdermal by unknown mechanism. Use Caution/Monitor. Closely monitor for evidence of enhanced CNS depression when using higher dose of magnesium sulfate together with a CNS depressant.sodium sulfate/potassium sulfate/magnesium sulfatesodium sulfate/potassium sulfate/magnesium sulfate increases effects of asenapine transdermal by unknown mechanism. Use Caution/Monitor. Closely monitor for evidence of enhanced CNS depression when using higher dose of magnesium sulfate together with a CNS depressant.sorafenibasenapine transdermal and sorafenib both increase QTc interval. Use Caution/Monitor.stiripentolasenapine transdermal and stiripentol both increase sedation. Use Caution/Monitor.sufentanilasenapine transdermal and sufentanil both increase sedation. Use Caution/Monitor.sufentanil SLasenapine transdermal and sufentanil SL both increase sedation. Use Caution/Monitor.suvorexantasenapine transdermal and suvorexant both increase sedation. Use Caution/Monitor.tapentadolasenapine transdermal and tapentadol both increase sedation. Use Caution/Monitor.tasimelteonasenapine transdermal and tasimelteon both increase sedation. Use Caution/Monitor.temazepamasenapine transdermal and temazepam both increase sedation. Use Caution/Monitor.tetrabenazineasenapine transdermal and tetrabenazine both increase sedation. Use Caution/Monitor.thioridazineasenapine transdermal and thioridazine both increase sedation. Use Caution/Monitor.thiothixeneasenapine transdermal and thiothixene both increase sedation. Use Caution/Monitor.tiagabineasenapine transdermal and tiagabine both increase sedation. Use Caution/Monitor.tizanidineasenapine transdermal and tizanidine both increase sedation. Use Caution/Monitor.tolcaponeasenapine transdermal and tolcapone both increase sedation. Use Caution/Monitor.topiramateasenapine transdermal and topiramate both increase sedation. Use Caution/Monitor.trazodoneasenapine transdermal and trazodone both increase sedation. Use Caution/Monitor.triclabendazoleasenapine transdermal and triclabendazole both increase QTc interval. Use Caution/Monitor.trifluoperazineasenapine transdermal and trifluoperazine both increase sedation. Use Caution/Monitor.trimipramineasenapine transdermal and trimipramine both increase QTc interval. Use Caution/Monitor.triprolidineasenapine transdermal and triprolidine both increase sedation. Use Caution/Monitor.valproic acidasenapine transdermal and valproic acid both increase sedation. Use Caution/Monitor.vigabatrinasenapine transdermal and vigabatrin both increase sedation. Use Caution/Monitor.voclosporinvoclosporin, asenapine transdermal. Either increases effects of the other by QTc interval. Use Caution/Monitor.zaleplonasenapine transdermal and zaleplon both increase sedation. Use Caution/Monitor.ziconotideasenapine transdermal and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneasenapine transdermal and ziprasidone both increase sedation. Use Caution/Monitor.zolpidemasenapine transdermal and zolpidem both increase sedation. Use Caution/Monitor.zonisamideasenapine transdermal and zonisamide both increase sedation. Use Caution/Monitor.Minor (0)acetaminophen/phenyltoloxamineMonitor Closely (1)asenapine transdermal and acetaminophen/phenyltoloxamine both increase sedation. Use Caution/Monitor.acrivastineMonitor Closely (1)acrivastine and asenapine transdermal both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)asenapine transdermal and albuterol both increase QTc interval. Use Caution/Monitor.alfentanilSerious - Use Alternative (1)asenapine transdermal and alfentanil both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatealfuzosinSerious - Use Alternative (1)asenapine transdermal and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug.alprazolamMonitor Closely (1)asenapine transdermal and alprazolam both increase sedation. Use Caution/Monitor.amiodaroneSerious - Use Alternative (1)asenapine transdermal and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideMonitor Closely (1)amisulpride and asenapine transdermal both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and amisulpride both increase QTc interval. Avoid or Use Alternate Drug.amitriptylineMonitor Closely (2)asenapine transdermal and amitriptyline both increase QTc interval. Use Caution/Monitor. asenapine transdermal and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)asenapine transdermal and amobarbital both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (2)asenapine transdermal and amoxapine both increase QTc interval. Use Caution/Monitor. asenapine transdermal and amoxapine both increase sedation. Use Caution/Monitor.anagrelideSerious - Use Alternative (1)asenapine transdermal and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.apomorphineSerious - Use Alternative (1)asenapine transdermal and apomorphine both increase QTc interval. Avoid or Use Alternate Drug.arformoterolMonitor Closely (1)asenapine transdermal and arformoterol both increase QTc interval. Use Caution/Monitor.aripiprazoleMonitor Closely (1)asenapine transdermal and aripiprazole both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and aripiprazole both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxideSerious - Use Alternative (1)asenapine transdermal and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherSerious - Use Alternative (1)asenapine transdermal and artemether both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineSerious - Use Alternative (1)asenapine transdermal and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapineMonitor Closely (1)asenapine and asenapine transdermal both increase sedation. Use Caution/Monitor.atomoxetineSerious - Use Alternative (1)asenapine transdermal and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.avapritinibMonitor Closely (1)asenapine transdermal and avapritinib both increase sedation. Use Caution/Monitor.azithromycinMonitor Closely (1)asenapine transdermal and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenMonitor Closely (1)asenapine transdermal and baclofen both increase sedation. Use Caution/Monitor.bedaquilineMonitor Closely (1)asenapine transdermal and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybenzhydrocodone/acetaminophenSerious - Use Alternative (1)asenapine transdermal and benzhydrocodone/acetaminophen both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebrexanoloneMonitor Closely (1)asenapine transdermal and brexanolone both increase sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)asenapine transdermal and brexpiprazole both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)asenapine transdermal and brimonidine both increase sedation. Use Caution/Monitor.brivaracetamMonitor Closely (1)asenapine transdermal and brivaracetam both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)asenapine transdermal and brompheniramine both increase sedation. Use Caution/Monitor.buprenorphineSerious - Use Alternative (2)asenapine transdermal and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug. asenapine transdermal and buprenorphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine buccalSerious - Use Alternative (1)asenapine transdermal and buprenorphine buccal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine subdermal implantSerious - Use Alternative (1)asenapine transdermal and buprenorphine subdermal implant both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)asenapine transdermal and buprenorphine transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionSerious - Use Alternative (1)asenapine transdermal and buprenorphine, long-acting injection both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)asenapine transdermal and butabarbital both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)asenapine transdermal and butalbital both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)asenapine transdermal and butorphanol both increase sedation. Use Caution/Monitor.carbinoxamineMonitor Closely (1)asenapine transdermal and carbinoxamine both increase sedation. Use Caution/Monitor.cariprazineMonitor Closely (1)asenapine transdermal and cariprazine both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)asenapine transdermal and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)asenapine transdermal and cenobamate both increase sedation. Use Caution/Monitor.ceritinibSerious - Use Alternative (1)asenapine transdermal and ceritinib both increase QTc interval. Avoid or Use Alternate Drug.cetirizineMonitor Closely (1)asenapine transdermal and cetirizine both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)asenapine transdermal and chlordiazepoxide both increase sedation. Use Caution/Monitor.chloroquineMonitor Closely (1)asenapine transdermal and chloroquine both increase QTc interval. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)asenapine transdermal and chlorpheniramine both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)asenapine transdermal and chlorpromazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.chlorzoxazoneMonitor Closely (1)asenapine transdermal and chlorzoxazone both increase sedation. Use Caution/Monitor.ciprofloxacinMonitor Closely (1)asenapine transdermal and ciprofloxacin both increase QTc interval. Use Caution/Monitor.citalopramMonitor Closely (1)asenapine transdermal and citalopram both increase QTc interval. Use Caution/Monitor.clarithromycinSerious - Use Alternative (1)asenapine transdermal and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clemastineMonitor Closely (1)asenapine transdermal and clemastine both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)asenapine transdermal and clobazam both increase sedation. Use Caution/Monitor.clomipramineMonitor Closely (2)asenapine transdermal and clomipramine both increase sedation. Use Caution/Monitor. asenapine transdermal and clomipramine both increase QTc interval. Use Caution/Monitor.clonazepamMonitor Closely (1)asenapine transdermal and clonazepam both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)asenapine transdermal and clonidine both increase sedation. Use Caution/Monitor.clorazepateMonitor Closely (1)asenapine transdermal and clorazepate both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)asenapine transdermal and clozapine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and clozapine both increase QTc interval. Avoid or Use Alternate Drug.codeineSerious - Use Alternative (1)asenapine transdermal and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatecrizotinibMonitor Closely (1)asenapine transdermal and crizotinib both increase QTc interval. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)asenapine transdermal and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)asenapine transdermal and cyproheptadine both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)asenapine transdermal and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)asenapine transdermal and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. dasatinibSerious - Use Alternative (1)asenapine transdermal and dasatinib both increase QTc interval. Avoid or Use Alternate Drug.degarelixSerious - Use Alternative (1)asenapine transdermal and degarelix both increase QTc interval. Avoid or Use Alternate Drug.desfluraneMonitor Closely (1)asenapine transdermal and desflurane both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and desflurane both increase QTc interval. Avoid or Use Alternate Drug.desipramineMonitor Closely (2)asenapine transdermal and desipramine both increase QTc interval. Use Caution/Monitor. asenapine transdermal and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (2)asenapine transdermal and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). asenapine transdermal and deutetrabenazine both increase sedation. Use Caution/Monitor.dexbrompheniramineMonitor Closely (1)asenapine transdermal and dexbrompheniramine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)asenapine transdermal and dexchlorpheniramine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)asenapine transdermal and diazepam both increase sedation. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and asenapine transdermal both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)asenapine transdermal and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)asenapine transdermal and dimenhydrinate both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)asenapine transdermal and diphenhydramine both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)asenapine transdermal and diphenoxylate hcl both increase sedation. Use Caution/Monitor.disopyramideSerious - Use Alternative (1)asenapine transdermal and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dofetilideSerious - Use Alternative (1)asenapine transdermal and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetronSerious - Use Alternative (1)asenapine transdermal and dolasetron both increase QTc interval. Avoid or Use Alternate Drug.donepezilSerious - Use Alternative (1)asenapine transdermal and donepezil both increase QTc interval. Avoid or Use Alternate Drug.doxepinMonitor Closely (2)asenapine transdermal and doxepin both increase QTc interval. Use Caution/Monitor. asenapine transdermal and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)asenapine transdermal and doxylamine both increase sedation. Use Caution/Monitor.dronedaroneContraindicated (1)asenapine transdermal and dronedarone both increase QTc interval. Contraindicated.droperidolMonitor Closely (1)asenapine transdermal and droperidol both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and droperidol both increase QTc interval. Avoid or Use Alternate Drug.efavirenzMonitor Closely (1)asenapine transdermal and efavirenz both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)asenapine transdermal and efavirenz both increase QTc interval. Avoid or Use Alternate Drug.eliglustatSerious - Use Alternative (1)asenapine transdermal and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.encorafenibSerious - Use Alternative (1)asenapine transdermal and encorafenib both increase QTc interval. Avoid or Use Alternate Drug.entacaponeMonitor Closely (1)asenapine transdermal and entacapone both increase sedation. Use Caution/Monitor.entrectinibSerious - Use Alternative (1)asenapine transdermal and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.eribulinSerious - Use Alternative (1)asenapine transdermal and eribulin both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseSerious - Use Alternative (1)asenapine transdermal and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)asenapine transdermal and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)asenapine transdermal and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)asenapine transdermal and erythromycin stearate both increase QTc interval. Avoid or