and paliperidone both increase sedation. Use Caution/Monitor.papaveretumclonazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverineclonazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocineclonazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and clonazepam both increase sedation. Use Caution/Monitor.perampanelperampanel and clonazepam both increase sedation. Use Caution/Monitor.perphenazineclonazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineclonazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and clonazepam both increase sedation. Use Caution/Monitor.phenobarbital will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phentermineclonazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineclonazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POclonazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinphenytoin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pholcodineclonazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozideclonazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolclonazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleposaconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pregabalinpregabalin, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and clonazepam both increase sedation. Use Caution/Monitor.prochlorperazineclonazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and clonazepam both increase sedation. Use Caution/Monitor.propofolpropofol and clonazepam both increase sedation. Use Caution/Monitor.propylhexedrineclonazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineclonazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamclonazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapineclonazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonclonazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, clonazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibribociclib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifabutinrifabutin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifampinrifampin will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifapentinerifapentine will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.risperidoneclonazepam and risperidone both increase sedation. Use Caution/Monitor.ritonavirritonavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.rucaparibrucaparib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.salmeterolclonazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.saquinavirsaquinavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.scullcapclonazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and clonazepam both increase sedation. Use Caution/Monitor.secobarbital will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. May also enhance CNS depressant effect of clonazepamsevelamersevelamer decreases levels of clonazepam by increasing elimination. Use Caution/Monitor.sevofluranesevoflurane and clonazepam both increase sedation. Use Caution/Monitor.shepherd's purseclonazepam and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, clonazepam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.stiripentol, clonazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanilclonazepam and sufentanil both increase sedation. Use Caution/Monitor.suvorexantsuvorexant and clonazepam both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessarytapentadolclonazepam and tapentadol both increase sedation. Use Caution/Monitor.tazemetostattazemetostat will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tecovirimattecovirimat will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.teduglutideteduglutide increases levels of clonazepam by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.temazepamclonazepam and temazepam both increase sedation. Use Caution/Monitor.terbutalineclonazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineclonazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixeneclonazepam and thiothixene both increase sedation. Use Caution/Monitor.tipranavirtipranavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.topiramateclonazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolclonazepam and tramadol both increase sedation. Use Caution/Monitor.trazodoneclonazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamclonazepam and triazolam both increase sedation. Use Caution/Monitor.triclofosclonazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazineclonazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipramineclonazepam and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and clonazepam both increase sedation. Use Caution/Monitor.voriconazolevoriconazole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.xylometazolineclonazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbineclonazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotideclonazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneclonazepam and ziprasidone both increase sedation. Use Caution/Monitor.zotepineclonazepam and zotepine both increase sedation. Use Caution/Monitor.Minor (38)acetaminophenclonazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen IVclonazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen rectalclonazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetazolamideacetazolamide will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anastrozoleanastrozole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.atracuriumclonazepam decreases effects of atracurium by pharmacodynamic antagonism. Minor/Significance Unknown.biotinclonazepam decreases levels of biotin by unspecified interaction mechanism. Minor/Significance Unknown. Biotin supplementation may be necessary.brimonidinebrimonidine increases effects of clonazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.ciprofloxacinciprofloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.cisatracuriumclonazepam decreases effects of cisatracurium by pharmacodynamic antagonism. Minor/Significance Unknown.cyanocobalaminclonazepam decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.cyclophosphamidecyclophosphamide will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.dexmethylphenidatedexmethylphenidate increases effects of clonazepam by decreasing metabolism. Minor/Significance Unknown.esomeprazoleesomeprazole will increase the level or effect of clonazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.eucalyptusclonazepam and eucalyptus both increase sedation. Minor/Significance Unknown.ezogabineezogabine decreases levels of clonazepam by Other (see comment). Minor/Significance Unknown. Comment: Ezogabine may induce glucuronidation that results in small decreases of trough levels.fleroxacinfleroxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.green teagreen tea decreases effects of clonazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.larotrectiniblarotrectinib will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.levocarnitineclonazepam decreases levels of levocarnitine by unspecified interaction mechanism. Minor/Significance Unknown.levofloxacinlevofloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.omeprazoleomeprazole increases levels of clonazepam by decreasing metabolism. Minor/Significance Unknown.onabotulinumtoxinAclonazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Minor/Significance Unknown.pancuroniumclonazepam decreases effects of pancuronium by pharmacodynamic antagonism. Minor/Significance Unknown.rapacuroniumclonazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of clonazepam by increasing metabolism. Minor/Significance Unknown.rimabotulinumtoxinBclonazepam decreases effects of rimabotulinumtoxinB by pharmacodynamic antagonism. Minor/Significance Unknown.rocuroniumclonazepam decreases effects of rocuronium by pharmacodynamic antagonism. Minor/Significance Unknown.sageclonazepam and sage both increase sedation. Minor/Significance Unknown.sage decreases effects of clonazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Theoretical interaction; some species of sage may cause convulsions.serdexmethylphenidate/dexmethylphenidateserdexmethylphenidate/dexmethylphenidate increases effects of clonazepam by decreasing metabolism. Minor/Significance Unknown.succinylcholineclonazepam decreases effects of succinylcholine by pharmacodynamic antagonism. Minor/Significance Unknown.valproic acidclonazepam, valproic acid. Mechanism: unknown. Minor/Significance Unknown. Possible risk of absence seizure.vecuroniumclonazepam decreases effects of vecuronium by pharmacodynamic antagonism. Minor/Significance Unknown.vinpocetineclonazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).zolpidemzolpidem, clonazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.abametapirSerious - Use Alternative (1)abametapir will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.acetaminophenMinor (1)clonazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen IVMinor (1)clonazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen rectalMinor (1)clonazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetazolamideMinor (1)acetazolamide will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.acrivastineMonitor Closely (1)acrivastine and clonazepam both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)clonazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)clonazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and clonazepam both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and clonazepam both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)clonazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (2)amobarbital and clonazepam both increase sedation. Use Caution/Monitor. amobarbital will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.amoxapineMonitor Closely (1)clonazepam and amoxapine both increase sedation. Use Caution/Monitor.anastrozoleMinor (1)anastrozole will increase the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.apalutamideSerious - Use Alternative (1)apalutamide will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphineMonitor Closely (1)clonazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)clonazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)clonazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)clonazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and clonazepam both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and clonazepam both increase sedation. Use Caution/Monitor.atazanavirMonitor Closely (1)atazanavir increases levels of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.atracuriumMinor (1)clonazepam decreases effects of atracurium by pharmacodynamic antagonism. Minor/Significance Unknown.avapritinibMonitor Closely (1)avapritinib and clonazepam both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and clonazepam both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)clonazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)clonazepam and belladonna and opium both increase sedation. Use Caution/Monitor.belzutifanMonitor Closely (1)belzutifan will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information. benperidolMonitor Closely (1)clonazepam and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, clonazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and clonazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)clonazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.biotinMinor (1)clonazepam decreases levels of biotin by unspecified interaction mechanism. Minor/Significance Unknown. Biotin supplementation may be necessary.bosentanMonitor Closely (1)bosentan will decrease the level or effect of clonazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, clonazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and clonazepam both increase