CYP2D6 metabolism. Minor/Significance Unknown.paroxetineMonitor Closely (1)chlorpromazine and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)paroxetine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.pasireotideMonitor Closely (1)chlorpromazine and pasireotide both decrease QTc interval. Modify Therapy/Monitor Closely.pazopanibMonitor Closely (1)chlorpromazine and pazopanib both increase QTc interval. Use Caution/Monitor.peginterferon alfa 2bMonitor Closely (1)peginterferon alfa 2b, chlorpromazine. Other (see comment). Use Caution/Monitor. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate.pentamidineContraindicated (1)chlorpromazine and pentamidine both increase QTc interval. Contraindicated.pentazocineMonitor Closely (1)pentazocine and chlorpromazine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and chlorpromazine both increase sedation. Use Caution/Monitor.Minor (1)pentobarbital decreases levels of chlorpromazine by increasing metabolism. Minor/Significance Unknown.perindoprilMinor (1)chlorpromazine increases effects of perindopril by unspecified interaction mechanism. Minor/Significance Unknown.perphenazineMonitor Closely (2)chlorpromazine and perphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and perphenazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.Minor (1)perphenazine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.pexidartinibSerious - Use Alternative (1)chlorpromazine and pexidartinib both increase Other (see comment). Avoid or Use Alternate Drug. Pexidartinib can cause hepatotoxicity. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity.phendimetrazineMonitor Closely (2)chlorpromazine, phendimetrazine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. chlorpromazine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (1)phenobarbital and chlorpromazine both increase sedation. Use Caution/Monitor.Minor (1)phenobarbital decreases levels of chlorpromazine by increasing metabolism. Minor/Significance Unknown.phentermineMonitor Closely (2)chlorpromazine, phentermine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. chlorpromazine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (2)chlorpromazine, phenylephrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. chlorpromazine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (2)chlorpromazine, phenylephrine PO. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. chlorpromazine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineMonitor Closely (1)chlorpromazine and pholcodine both increase sedation. Use Caution/Monitor.pimozideContraindicated (1)chlorpromazine and pimozide both increase QTc interval. Contraindicated.Monitor Closely (2)chlorpromazine and pimozide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)chlorpromazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pitolisantSerious - Use Alternative (1)chlorpromazine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodSerious - Use Alternative (1)ponesimod, chlorpromazine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Consult cardiologist if considering treatment. Generally, should not be initiated in patients who are concurrently taking QT prolonging drugs with known arrhythmogenic properties, such as HR-lowering calcium channel blockers (eg, verapamil, diltiazem).porfimerMonitor Closely (1)chlorpromazine, porfimer. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Enhanced photosensitivity.posaconazoleMonitor Closely (1)chlorpromazine and posaconazole both increase QTc interval. Modify Therapy/Monitor Closely.pralidoximeMonitor Closely (3)pralidoxime decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. pralidoxime decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor. chlorpromazine increases effects of pralidoxime by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pramipexoleSerious - Use Alternative (1)chlorpromazine decreases effects of pramipexole by pharmacodynamic antagonism. Contraindicated.primaquineSerious - Use Alternative (1)primaquine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.primidoneMonitor Closely (1)primidone and chlorpromazine both increase sedation. Use Caution/Monitor.Minor (1)primidone decreases levels of chlorpromazine by increasing metabolism. Minor/Significance Unknown.procainamideContraindicated (1)chlorpromazine and procainamide both increase QTc interval. Contraindicated.procarbazineMonitor Closely (1)procarbazine, chlorpromazine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Excessive sedation.prochlorperazineMonitor Closely (2)chlorpromazine and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and prochlorperazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and prochlorperazine both increase QTc interval. Avoid or Use Alternate Drug.promazineSerious - Use Alternative (1)chlorpromazine and promazine both increase QTc interval. Avoid or Use Alternate Drug.promethazineMonitor Closely (2)chlorpromazine and promethazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. promethazine and chlorpromazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and promethazine both increase QTc interval. Avoid or Use Alternate Drug.propafenoneSerious - Use Alternative (1)propafenone will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.propanthelineMonitor Closely (3)propantheline decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. propantheline decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor. chlorpromazine increases effects of propantheline by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.propofolMonitor Closely (1)propofol and chlorpromazine both increase sedation. Use Caution/Monitor.propranololSerious - Use Alternative (1)propranolol, chlorpromazine. Either increases levels of the other by decreasing metabolism. Contraindicated. Not all beta blockers share this interaction (e.g., atenolol, nadolol, sotalol do not interact).propylhexedrineMonitor Closely (2)chlorpromazine, propylhexedrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. chlorpromazine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)chlorpromazine and protriptyline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and protriptyline both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)protriptyline, chlorpromazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects. protriptyline, chlorpromazine. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.pseudoephedrineMonitor Closely (1)chlorpromazine, pseudoephedrine. Mechanism: unknown. Use Caution/Monitor. Consider avoiding use of pseudoephedrine in patients receiving phenothiazines (especially thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. Monitor for evidence of ventricular arrhythmias during concomitant use.pyrimethamineMinor (1)pyrimethamine increases levels of chlorpromazine by decreasing metabolism. Minor/Significance Unknown.quazepamMonitor Closely (1)quazepam and chlorpromazine both increase sedation. Use Caution/Monitor.quetiapineMonitor Closely (3)chlorpromazine and quetiapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and quetiapine both increase sedation. Use Caution/Monitor. quetiapine, chlorpromazine. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT.quinacrineMinor (1)quinacrine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.quinaprilMinor (1)chlorpromazine increases effects of quinapril by unspecified interaction mechanism. Minor/Significance Unknown.quinidineContraindicated (1)chlorpromazine and quinidine both increase QTc interval. Contraindicated.Monitor Closely (1)quinidine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)quinidine, chlorpromazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive cardiac effects.quinineMonitor Closely (1)chlorpromazine and quinine both increase QTc interval. Use Caution/Monitor.ramelteonMonitor Closely (1)chlorpromazine and ramelteon both increase sedation. Use Caution/Monitor.ramiprilMinor (1)chlorpromazine increases effects of ramipril by unspecified interaction mechanism. Minor/Significance Unknown.ranolazineMonitor Closely (1)chlorpromazine and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.Minor (1)ranolazine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.rapacuroniumMonitor Closely (3)rapacuronium decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. rapacuronium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor. chlorpromazine increases effects of rapacuronium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.ribociclibSerious - Use Alternative (1)ribociclib increases toxicity of chlorpromazine by QTc interval. Avoid or Use Alternate Drug.rilpivirineMonitor Closely (1)rilpivirine increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes.rimabotulinumtoxinBMonitor Closely (1)chlorpromazine, rimabotulinumtoxinB. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Anticholinergics may enhance botulinum toxin effects. Closely monitor for increased neuromuscular blockade.risperidoneMonitor Closely (3)chlorpromazine and risperidone both increase QTc interval. Modify Therapy/Monitor Closely. chlorpromazine and risperidone both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and risperidone both increase sedation. Use Caution/Monitor.ritonavirMinor (1)ritonavir will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.rocuroniumMonitor Closely (3)rocuronium decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. rocuronium decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor. chlorpromazine increases effects of rocuronium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.rolapitantMonitor Closely (1)rolapitant will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.romidepsinMonitor Closely (1)chlorpromazine and romidepsin both increase QTc interval. Modify Therapy/Monitor Closely.ropiniroleSerious - Use Alternative (1)chlorpromazine decreases effects of ropinirole by pharmacodynamic antagonism. Contraindicated.sageMinor (1)chlorpromazine and sage both increase sedation. Minor/Significance Unknown.salmeterolMonitor Closely (1)chlorpromazine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.saquinavirMonitor Closely (1)saquinavir, chlorpromazine. Either increases toxicity of the other by QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available. Increased risk of PR or QT prolongation and cardiac arrhythmias.scopolamineMonitor Closely (3)scopolamine decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. scopolamine decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor. chlorpromazine increases effects of scopolamine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.scullcapMonitor Closely (1)chlorpromazine and scullcap both increase sedation. Use Caution/Monitor.secobarbitalMonitor Closely (1)secobarbital and chlorpromazine both increase sedation. Use Caution/Monitor.Minor (1)secobarbital decreases levels of chlorpromazine by increasing metabolism. Minor/Significance Unknown.selinexorSerious - Use Alternative (1)selinexor, chlorpromazine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.selpercatinibMonitor Closely (1)selpercatinib increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidateMonitor Closely (1)chlorpromazine, serdexmethylphenidate/dexmethylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.sertralineSerious - Use Alternative (1)sertraline and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.Minor (1)sertraline will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.sevofluraneMonitor Closely (1)sevoflurane and chlorpromazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)sevoflurane and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.shepherd's purseMonitor Closely (1)chlorpromazine and shepherd's purse both increase sedation. Use Caution/Monitor.siponimodSerious - Use Alternative (1)siponimod and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.smokingMonitor Closely (1)smoking decreases levels of chlorpromazine by increasing metabolism. Use Caution/Monitor. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines.sodium oxybateSerious - Use Alternative (1)chlorpromazine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.sodium picosulfate/magnesium oxide/anhydrous citric acidMonitor Closely (1)sodium picosulfate/magnesium oxide/anhydrous citric acid decreases levels of chlorpromazine by cation binding in GI tract. Use Caution/Monitor. Take at least 2 hours before and not less than 6 hours after administration of sodium picosulfate, magnesium oxide and anhydrous citric acid to avoid magnesium chelation .sodium sulfate/?magnesium sulfate/potassium chlorideMonitor Closely (2)sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias. . sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Administer chlorpromazine at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. .sodium sulfate/potassium sulfate/magnesium sulfateMonitor Closely (2)sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of chlorpromazine by QTc interval. Use Caution/Monitor. Consider