Use alternatives if available. Potential for increased toxicity. Consider lowering benzodiazepine dose.rolapitantrolapitant will increase the level or effect of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.rucaparibrucaparib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.salmeterolchlordiazepoxide increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.saquinavirsaquinavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.scullcapchlordiazepoxide and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.secobarbital will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. May also enhance CNS depressant effect of chlordiazepoxidesevofluranesevoflurane and chlordiazepoxide both increase sedation. Use Caution/Monitor.shepherd's pursechlordiazepoxide and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, chlordiazepoxide. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.stiripentol, chlordiazepoxide. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanilchlordiazepoxide and sufentanil both increase sedation. Use Caution/Monitor.suvorexantsuvorexant and chlordiazepoxide both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessarytapentadolchlordiazepoxide and tapentadol both increase sedation. Use Caution/Monitor.tazemetostattazemetostat will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tecovirimattecovirimat will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.teduglutideteduglutide increases levels of chlordiazepoxide by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.temazepamchlordiazepoxide and temazepam both increase sedation. Use Caution/Monitor.terbinafineterbinafine will increase the level or effect of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Assess need to reduce dose of CYP2D6-metabolized drug.terbutalinechlordiazepoxide increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazinechlordiazepoxide and thioridazine both increase sedation. Use Caution/Monitor.thiothixenechlordiazepoxide and thiothixene both increase sedation. Use Caution/Monitor.tipranavirtipranavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.topiramatechlordiazepoxide and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolchlordiazepoxide and tramadol both increase sedation. Use Caution/Monitor.trazodonechlordiazepoxide and trazodone both increase sedation. Use Caution/Monitor.triazolamchlordiazepoxide and triazolam both increase sedation. Use Caution/Monitor.triclofoschlordiazepoxide and triclofos both increase sedation. Use Caution/Monitor.trifluoperazinechlordiazepoxide and trifluoperazine both increase sedation. Use Caution/Monitor.trimipraminechlordiazepoxide and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.voriconazolevoriconazole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.xylometazolinechlordiazepoxide increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinechlordiazepoxide increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidechlordiazepoxide and ziconotide both increase sedation. Use Caution/Monitor.ziprasidonechlordiazepoxide and ziprasidone both increase sedation. Use Caution/Monitor.zotepinechlordiazepoxide and zotepine both increase sedation. Use Caution/Monitor.Minor (29)acetazolamideacetazolamide will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anastrozoleanastrozole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.brimonidinebrimonidine increases effects of chlordiazepoxide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.ciprofloxacinciprofloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.clotrimazoleclotrimazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.cyclophosphamidecyclophosphamide will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.disulfiramdisulfiram increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.esomeprazoleesomeprazole will increase the level or effect of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.eucalyptuschlordiazepoxide and eucalyptus both increase sedation. Minor/Significance Unknown.fleroxacinfleroxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.fluconazolefluconazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.green teagreen tea decreases effects of chlordiazepoxide by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.ketoconazoleketoconazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.larotrectiniblarotrectinib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.levofloxacinlevofloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.levoketoconazolelevoketoconazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.metyraponechlordiazepoxide decreases effects of metyrapone by unspecified interaction mechanism. Minor/Significance Unknown.miconazole vaginalmiconazole vaginal increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.omeprazoleomeprazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.posaconazoleposaconazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of chlordiazepoxide by increasing metabolism. Minor/Significance Unknown.rifampinrifampin decreases levels of chlordiazepoxide by increasing metabolism. Minor/Significance Unknown.sagechlordiazepoxide and sage both increase sedation. Minor/Significance Unknown.vinpocetinechlordiazepoxide increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).voriconazolevoriconazole increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown.zolpidemzolpidem, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.abametapirSerious - Use Alternative (1)abametapir will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.abirateroneMonitor Closely (1)abiraterone increases levels of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.acetazolamideMinor (1)acetazolamide will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.acrivastineMonitor Closely (1)acrivastine and chlordiazepoxide both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)chlordiazepoxide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)chlordiazepoxide and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and chlordiazepoxide both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and chlordiazepoxide both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)chlordiazepoxide and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (2)amobarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor. amobarbital will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.amoxapineMonitor Closely (1)chlordiazepoxide and amoxapine both increase sedation. Use Caution/Monitor.anastrozoleMinor (1)anastrozole will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.apalutamideSerious - Use Alternative (1)apalutamide will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphineMonitor Closely (1)chlordiazepoxide and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)chlordiazepoxide increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)chlordiazepoxide and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)chlordiazepoxide increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and chlordiazepoxide both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and chlordiazepoxide both increase sedation. Use Caution/Monitor.atazanavirMonitor Closely (1)atazanavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.avapritinibMonitor Closely (1)avapritinib and chlordiazepoxide both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and chlordiazepoxide both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)chlordiazepoxide and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)chlordiazepoxide and belladonna and opium both increase sedation. Use Caution/Monitor.belzutifanMonitor Closely (1)belzutifan will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information. benperidolMonitor Closely (1)chlordiazepoxide and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, chlordiazepoxide. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and chlordiazepoxide both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)chlordiazepoxide increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bosentanMonitor Closely (1)bosentan will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, chlordiazepoxide. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and chlordiazepoxide both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and chlordiazepoxide both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of chlordiazepoxide by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and chlordiazepoxide both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)chlordiazepoxide and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)chlordiazepoxide and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)chlordiazepoxide increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.Serious - Use Alternative (1)buprenorphine subdermal implant and chlordiazepoxide both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and chlordiazepoxide both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionMonitor Closely (1)chlordiazepoxide increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.Serious - Use Alternative (1)buprenorphine, long-acting injection and chlordiazepoxide both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)butabarbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and chlordiazepoxide both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)chlordiazepoxide and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)chlordiazepoxide increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)chlordiazepoxide, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carbamazepineMonitor Closely (1)carbamazepine will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.carbinoxamineMonitor Closely (1)carbinoxamine and chlordiazepoxide both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)chlordiazepoxide and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, chlordiazepoxide. Either increases effects of the other by sedation. Use Caution/Monitor.ceritinibMonitor Closely (1)ceritinib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.chloral hydrateMonitor Closely (1)chlordiazepoxide and chloral hydrate both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)chlordiazepoxide and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)chlordiazepoxide and chlorzoxazone both increase sedation. Use Caution/Monitor.cimetidineMonitor Closely (1)cimetidine increases levels of chlordiazepoxide by decreasing metabolism. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and chlordiazepoxide both increase sedation.