or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexamineamitriptyline, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dosulepinperphenazine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.dosulepinamitriptyline and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and dosulepin both increase serotonin levels. Avoid or Use Alternate Drug.doxepinamitriptyline and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.perphenazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and doxepin both increase QTc interval. Avoid or Use Alternate Drug.dronedaronedronedarone and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.perphenazine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolperphenazine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineduloxetine and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.epinephrineepinephrine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.encorafenibencorafenib and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.ephedrineamitriptyline, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineepinephrine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine racemicepinephrine racemic and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemic and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.erythromycin baseamitriptyline and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin base will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.erythromycin base will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.perphenazine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateerythromycin ethylsuccinate will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.erythromycin ethylsuccinate will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.perphenazine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateerythromycin lactobionate will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.erythromycin lactobionate will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.perphenazine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateerythromycin stearate will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.erythromycin stearate will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.perphenazine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramescitalopram and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.escitalopram increases toxicity of amitriptyline by QTc interval. Avoid or Use Alternate Drug.fentanylfentanyl, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fenfluramineamitriptyline, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fentanyl intranasalfentanyl intranasal, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalfentanyl transdermal, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalfentanyl transmucosal, perphenazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fexinidazolefexinidazole and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fluconazoleamitriptyline and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.perphenazine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug.perphenazine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.fluoxetine and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.perphenazine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluoxetine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluphenazinefluphenazine and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.fluphenazine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.fluvoxaminefluvoxamine and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.formoterolperphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.formoterolamitriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fosamprenavirfosamprenavir increases levels of amitriptyline by decreasing metabolism. Avoid or Use Alternate Drug.givosirangivosiran will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.givosiran will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.granisetrongranisetron, amitriptyline. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.granisetron and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.haloperidolperphenazine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.guanfacineamitriptyline decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.haloperidolamitriptyline and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydrocodonehydrocodone, perphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).hydroxychloroquine sulfatehydroxychloroquine sulfate and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.hydroxychloroquine sulfate and perphenazine both increase QTc interval. Avoid or Use Alternate Drug.imipramineamitriptyline and imipramine both increase QTc interval. Avoid or Use Alternate Drug.perphenazine and imipramine both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.iobenguane I 131amitriptyline will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.isocarboxazidisocarboxazid, perphenazine. Other (see comment). Contraindicated. Comment: Concurrent use may prolong or intensify the hypotensive, anticholinergic, or sedative effects of isocarboxazid or perphenazine.isoproterenolamitriptyline, isoproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.itraconazoleperphenazine and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib and perphenazine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ivosidenib and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazoleperphenazine and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lasmiditanlasmiditan increases effects of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.levodopaperphenazine decreases effects of levodopa by pharmacodynamic antagonism. Avoid or Use Alternate Drug.lefamulinlefamulin and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.levalbuterolamitriptyline, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.levodopa inhaledperphenazine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Phenothiazine/1st generation antipsychotics inhibit dopamine D2 receptors in varying degrees.levoketoconazoleperphenazine and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranlevomilnacipran and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.lisurideperphenazine decreases effects of lisuride by pharmacodynamic antagonism. Contraindicated.linezolidlinezolid and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.lisdexamfetamineamitriptyline, lisdexamfetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lofepramineamitriptyline and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and lofepramine both increase serotonin levels. Avoid or Use Alternate Drug.perphenazine and lofepramine both increase QTc interval. Avoid or Use Alternate Drug.lorcaserinamitriptyline and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.perphenazine and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.lumefantrineperphenazine and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinmacimorelin and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.macimorelin and perphenazine both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong