interval. Avoid or Use Alternate Drug.buprenorphine buccalMonitor Closely (1)buprenorphine buccal and lofexidine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantSerious - Use Alternative (1)buprenorphine subdermal implant and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionSerious - Use Alternative (1)buprenorphine, long-acting injection and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.bupropionMonitor Closely (1)bupropion will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.butabarbitalMonitor Closely (1)butabarbital and lofexidine both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and lofexidine both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol and lofexidine both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)lofexidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)lofexidine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.candesartanSerious - Use Alternative (1)lofexidine, candesartan. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.captoprilSerious - Use Alternative (1)lofexidine, captopril. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.carbinoxamineMonitor Closely (1)carbinoxamine and lofexidine both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)carisoprodol and lofexidine both increase sedation. Use Caution/Monitor.carvedilolSerious - Use Alternative (1)lofexidine, carvedilol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.ceritinibSerious - Use Alternative (1)ceritinib and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.chloral hydrateMonitor Closely (1)chloral hydrate and lofexidine both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and lofexidine both increase sedation. Use Caution/Monitor.chloroquineMonitor Closely (1)chloroquine increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.chlorothiazideSerious - Use Alternative (1)lofexidine, chlorothiazide. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.chlorpheniramineMonitor Closely (1)chlorpheniramine and lofexidine both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)chlorpromazine and lofexidine both increase sedation. Use Caution/Monitor.chlorpropamideMonitor Closely (1)chlorpropamide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.chlorthalidoneSerious - Use Alternative (1)lofexidine, chlorthalidone. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.chlorzoxazoneMonitor Closely (1)chlorzoxazone and lofexidine both increase sedation. Use Caution/Monitor.cinacalcetMonitor Closely (1)cinacalcet will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.cinnarizineMonitor Closely (1)cinnarizine and lofexidine both increase sedation. Use Caution/Monitor.citalopramMonitor Closely (1)citalopram and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.clarithromycinSerious - Use Alternative (1)clarithromycin and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.clemastineMonitor Closely (1)clemastine and lofexidine both increase sedation. Use Caution/Monitor.clevidipineSerious - Use Alternative (1)lofexidine, clevidipine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.clofazimineMonitor Closely (1)clofazimine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.clomipramineMonitor Closely (2)clomipramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. clomipramine and lofexidine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and lofexidine both increase sedation. Use Caution/Monitor.clonidineSerious - Use Alternative (1)lofexidine, clonidine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.clorazepateMonitor Closely (1)clorazepate and lofexidine both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)clozapine and lofexidine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)clozapine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.cocaine topicalMonitor Closely (1)cocaine topical will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.codeineMonitor Closely (1)codeine and lofexidine both increase sedation. Use Caution/Monitor.crizotinibSerious - Use Alternative (1)crizotinib and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.cyclizineMonitor Closely (1)cyclizine and lofexidine both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)cyclobenzaprine and lofexidine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and lofexidine both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)dantrolene and lofexidine both increase sedation. Use Caution/Monitor.darunavirMonitor Closely (1)darunavir will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.dasatinibSerious - Use Alternative (1)dasatinib and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.degarelixSerious - Use Alternative (1)degarelix and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.desfluraneMonitor Closely (1)desflurane and lofexidine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)desflurane and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.desipramineMonitor Closely (2)desipramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. desipramine and lofexidine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)deutetrabenazine and lofexidine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and lofexidine both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)lofexidine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine and lofexidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)lofexidine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)lofexidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)dextromoramide and lofexidine both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine and lofexidine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and lofexidine both increase sedation. Use Caution/Monitor.diethylpropionMonitor Closely (1)lofexidine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl and lofexidine both increase sedation. Use Caution/Monitor.diltiazemSerious - Use Alternative (1)lofexidine, diltiazem. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.dimenhydrinateMonitor Closely (1)dimenhydrinate and lofexidine both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and lofexidine both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl and lofexidine both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone and lofexidine both increase sedation. Use Caution/Monitor.disopyramideMonitor Closely (1)disopyramide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.dobutamineMonitor Closely (1)lofexidine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dofetilideMonitor Closely (1)dofetilide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.dolasetronSerious - Use Alternative (1)dolasetron and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.donepezilSerious - Use Alternative (1)donepezil and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.dopamineMonitor Closely (1)lofexidine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)lofexidine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepinMonitor Closely (3)doxepin decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. doxepin and lofexidine both increase QTc interval. Use Caution/Monitor. doxepin and lofexidine both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)doxylamine and lofexidine both increase sedation. Use Caution/Monitor.dronedaroneMonitor Closely (1)dronedarone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.droperidolMonitor Closely (1)droperidol and lofexidine both increase sedation. Use Caution/Monitor.efavirenzSerious - Use Alternative (1)efavirenz and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.eliglustatMonitor Closely (1)eliglustat and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.enalaprilSerious - Use Alternative (1)lofexidine, enalapril. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.encorafenibSerious - Use Alternative (1)encorafenib and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.entrectinibSerious - Use Alternative (1)lofexidine and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.ephedrineMonitor Closely (1)lofexidine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)lofexidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)lofexidine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.eplerenoneSerious - Use Alternative (1)lofexidine, eplerenone. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.epoprostenolSerious - Use Alternative (1)lofexidine, epoprostenol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.eprosartanSerious - Use Alternative (1)lofexidine, eprosartan. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.eribulinSerious - Use Alternative (1)eribulin and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.escitalopramMonitor Closely (1)escitalopram increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.esmololSerious - Use Alternative (1)lofexidine, esmolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.estazolamMonitor Closely (1)estazolam and lofexidine both increase sedation. Use Caution/Monitor.ethacrynic acidSerious - Use Alternative (1)lofexidine, ethacrynic acid. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.ethanolMonitor Closely (1)ethanol and lofexidine both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and lofexidine both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)eucalyptus and lofexidine both increase sedation. Minor/Significance Unknown.felodipineSerious - Use Alternative (1)lofexidine, felodipine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.fenfluramineMonitor Closely (1)lofexidine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fenoldopamSerious - Use Alternative (1)lofexidine, fenoldopam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.fexinidazoleSerious - Use Alternative (1)fexinidazole and lofexidine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fingolimodSerious - Use Alternative (1)fingolimod and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.fluoxetineMonitor Closely (2)fluoxetine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended. fluoxetine will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis