quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.temazepamquazepam and temazepam both increase sedation. Use Caution/Monitor.terbutalinequazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazinequazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixenequazepam and thiothixene both increase sedation. Use Caution/Monitor.topiramatequazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolquazepam and tramadol both increase sedation. Use Caution/Monitor.trazodonequazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamquazepam and triazolam both increase sedation. Use Caution/Monitor.triclofosquazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazinequazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipraminequazepam and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and quazepam both increase sedation. Use Caution/Monitor.voriconazolevoriconazole will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.xylometazolinequazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinequazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidequazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidonequazepam and ziprasidone both increase sedation. Use Caution/Monitor.zotepinequazepam and zotepine both increase sedation. Use Caution/Monitor.Minor (17)acetazolamideacetazolamide will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anastrozoleanastrozole will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.brimonidinebrimonidine increases effects of quazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.ciprofloxacinciprofloxacin increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.cyclophosphamidecyclophosphamide will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.eucalyptusquazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fleroxacinfleroxacin increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.larotrectiniblarotrectinib will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.levofloxacinlevofloxacin increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.omeprazoleomeprazole increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of quazepam by increasing metabolism. Minor/Significance Unknown.sagequazepam and sage both increase sedation. Minor/Significance Unknown.vinpocetinequazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).zolpidemzolpidem, quazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.abametapirSerious - Use Alternative (1)abametapir will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.acetazolamideMinor (1)acetazolamide will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.acrivastineMonitor Closely (1)acrivastine and quazepam both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)quazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)quazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and quazepam both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and quazepam both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)quazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (2)amobarbital and quazepam both increase sedation. Use Caution/Monitor. amobarbital will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.amoxapineMonitor Closely (1)quazepam and amoxapine both increase sedation. Use Caution/Monitor.anastrozoleMinor (1)anastrozole will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.apalutamideSerious - Use Alternative (1)apalutamide will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphineMonitor Closely (1)quazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)quazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)quazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)quazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and quazepam both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and quazepam both increase sedation. Use Caution/Monitor.avapritinibMonitor Closely (1)avapritinib and quazepam both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and quazepam both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)quazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)quazepam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)quazepam and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, quazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and quazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)quazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bosentanMonitor Closely (1)bosentan will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, quazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and quazepam both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and quazepam both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of quazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and quazepam both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and quazepam both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)quazepam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)quazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)quazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.Serious - Use Alternative (1)buprenorphine subdermal implant and quazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and quazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionMonitor Closely (1)quazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.Serious - Use Alternative (1)buprenorphine, long-acting injection and quazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)butabarbital and quazepam both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and quazepam both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)quazepam and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)quazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesContraindicated (1)quazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.carbamazepineMonitor Closely (1)carbamazepine will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.carbinoxamineMonitor Closely (1)carbinoxamine and quazepam both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)quazepam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (2)cenobamate, quazepam. Either increases effects of the other by sedation. Use Caution/Monitor. cenobamate will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.ceritinibMonitor Closely (1)ceritinib will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.chloral hydrateMonitor Closely (1)quazepam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and quazepam both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and quazepam both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)quazepam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)quazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and quazepam both increase sedation. Use Caution/Monitor.ciprofloxacinMinor (1)ciprofloxacin increases levels of quazepam by decreasing metabolism. Minor/Significance Unknown.clarithromycinMonitor Closely (1)clarithromycin will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.clemastineMonitor Closely (1)clemastine and quazepam both increase sedation. Use Caution/Monitor.clomipramineMonitor Closely (1)quazepam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and quazepam both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, quazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateMonitor Closely (1)clorazepate and quazepam both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)quazepam and clozapine both increase sedation. Use Caution/Monitor.cobicistatMonitor Closely (1)cobicistat will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.codeineMonitor Closely (1)quazepam and codeine both increase sedation. Use Caution/Monitor.conivaptanSerious - Use Alternative (1)conivaptan will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.crofelemerMonitor Closely (1)crofelemer increases levels of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.cyclizineMonitor Closely (1)cyclizine and quazepam both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)quazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyclophosphamideMinor (1)cyclophosphamide will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.cyproheptadineMonitor Closely (1)cyproheptadine and quazepam both increase sedation. Use Caution/Monitor.dabrafenibMonitor Closely (1)dabrafenib will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.dantroleneMonitor Closely (1)quazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)quazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darunavirSerious - Use Alternative (1)darunavir will increase the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.desfluraneMonitor Closely (1)desflurane and quazepam both increase sedation. Use Caution/Monitor.desipramineMonitor Closely (1)quazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)quazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and quazepam both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)quazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)quazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)quazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)quazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)quazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)quazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and quazepam both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, quazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionMonitor Closely (1)quazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and quazepam both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)quazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and quazepam both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and quazepam both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)quazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)quazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineMonitor Closely (1)quazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)quazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)quazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)quazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)quazepam and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)quazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)quazepam and