dose of clorazepate if necessarycodeineMonitor Closely (1)clorazepate and codeine both increase sedation. Use Caution/Monitor.conivaptanSerious - Use Alternative (1)conivaptan will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.crofelemerMonitor Closely (1)crofelemer increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.cyclizineMonitor Closely (1)cyclizine and clorazepate both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)clorazepate and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyclophosphamideMinor (1)cyclophosphamide will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.cyproheptadineMonitor Closely (1)cyproheptadine and clorazepate both increase sedation. Use Caution/Monitor.dabrafenibMonitor Closely (1)dabrafenib will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.dantroleneMonitor Closely (1)clorazepate and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)clorazepate and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darunavirMonitor Closely (1)darunavir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.desfluraneMonitor Closely (1)desflurane and clorazepate both increase sedation. Use Caution/Monitor.desipramineMonitor Closely (1)clorazepate and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)clorazepate and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and clorazepate both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)clorazepate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)clorazepate and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)clorazepate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)clorazepate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)clorazepate and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)clorazepate and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)clorazepate and diazepam both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionMonitor Closely (1)clorazepate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and clorazepate both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)clorazepate and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and clorazepate both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and clorazepate both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)clorazepate and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)clorazepate and dipipanone both increase sedation. Use Caution/Monitor.disulfiramMonitor Closely (1)disulfiram increases levels of clorazepate by decreasing metabolism. Use Caution/Monitor.dobutamineMonitor Closely (1)clorazepate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)clorazepate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)clorazepate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)clorazepate and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)clorazepate and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)clorazepate and doxylamine both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)clorazepate and droperidol both increase sedation. Use Caution/Monitor.efavirenzMonitor Closely (1)efavirenz will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.elagolixMonitor Closely (1)elagolix will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.elvitegravir/cobicistat/emtricitabine/tenofovir DFMonitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.encorafenibMonitor Closely (1)encorafenib, clorazepate. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.enzalutamideSerious - Use Alternative (1)enzalutamide will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.ephedrineMonitor Closely (1)clorazepate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)clorazepate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)clorazepate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)esketamine intranasal, clorazepate. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamMonitor Closely (1)clorazepate and estazolam both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (1)clorazepate and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and clorazepate both increase sedation. Use Caution/Monitor.etravirineMonitor Closely (1)etravirine will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.eucalyptusMinor (1)clorazepate and eucalyptus both increase sedation. Minor/Significance Unknown.fedratinibMonitor Closely (1)fedratinib will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.fenfluramineMonitor Closely (1)clorazepate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fexinidazoleSerious - Use Alternative (1)fexinidazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.fleroxacinMinor (1)fleroxacin increases levels of clorazepate by decreasing metabolism. Minor/Significance Unknown.flibanserinMonitor Closely (1)clorazepate and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineMonitor Closely (1)clorazepate and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)clorazepate and flurazepam both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)clorazepate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosamprenavirMonitor Closely (1)fosamprenavir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available. Consider lowering benzodiazepine dose.fosphenytoinMonitor Closely (1)fosphenytoin will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.gabapentinMonitor Closely (1)gabapentin, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, clorazepate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)clorazepate and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinMinor (1)gemifloxacin increases levels of clorazepate by decreasing metabolism. Minor/Significance Unknown.green teaMinor (1)green tea decreases effects of clorazepate by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.haloperidolMonitor Closely (1)clorazepate and haloperidol both increase sedation. Use Caution/Monitor.hydrocodoneSerious - Use Alternative (1)hydrocodone, clorazepate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)clorazepate and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and clorazepate both increase sedation. Use Caution/Monitor.idelalisibSerious - Use Alternative (1)idelalisib will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substratesiloperidoneMonitor Closely (2)clorazepate and iloperidone both increase sedation. Use Caution/Monitor. iloperidone increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.imipramineMonitor Closely (1)clorazepate and imipramine both increase sedation. Use Caution/Monitor.indinavirMonitor Closely (1)indinavir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.isoniazidMonitor Closely (1)isoniazid will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.isoproterenolMonitor Closely (1)clorazepate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.istradefyllineMonitor Closely (1)istradefylline will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.itraconazoleMonitor Closely (1)itraconazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ivosidenibSerious - Use Alternative (1)ivosidenib will decrease the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.ketamineMonitor Closely (1)ketamine and clorazepate both increase sedation. Use Caution/Monitor.ketoconazoleMonitor Closely (1)ketoconazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.ketotifen, ophthalmicMonitor Closely (1)clorazepate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.larotrectinibMinor (1)larotrectinib will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.lasmiditanMonitor Closely (1)lasmiditan, clorazepate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantMonitor Closely (1)lemborexant, clorazepate. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.lenacapavirMonitor Closely (1)lenacapavir will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir (a moderate CYP3A4 inhibitor) may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. letermovirMonitor Closely (1)letermovir increases levels of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterolMonitor Closely (1)clorazepate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levofloxacinMinor (1)levofloxacin increases levels of clorazepate by decreasing metabolism. Minor/Significance Unknown.levoketoconazoleMonitor Closely (1)levoketoconazole will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.levorphanolMonitor Closely (1)clorazepate and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)clorazepate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineMonitor Closely (1)clorazepate and lofepramine both increase sedation. Use Caution/Monitor.lofexidineMonitor Closely (1)clorazepate and lofexidine both increase sedation. Use Caution/Monitor.lonafarnibSerious - Use Alternative (1)lonafarnib will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.lopinavirSerious - Use Alternative (1)lopinavir will increase the level or effect of clorazepate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.loprazolamMonitor Closely (1)clorazepate and loprazolam both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)clorazepate and lorazepam both increase sedation. Use Caution/Monitor.lormetazepamMonitor Closely (1)clorazepate and lormetazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)clorazepate and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)clorazepate and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, clorazepate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineMonitor Closely (1)clorazepate and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)clorazepate and marijuana both increase sedation. Use Caution/Monitor.melatoninMonitor Closely (1)clorazepate and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)clorazepate and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)clorazepate and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)clorazepate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)clorazepate and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)clorazepate and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)clorazepate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)clorazepate and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)clorazepate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidate transdermalMonitor Closely (1)methylphenidate transdermal will increase the level or effect of clorazepate by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. metoclopramide intranasalSerious - Use Alternative (1)clorazepate, metoclopramide intranasal. Either