and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.fluphenazineMonitor Closely (1)fluphenazine and lofexidine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam and lofexidine both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)lofexidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosinoprilSerious - Use Alternative (1)lofexidine, fosinopril. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.fostemsavirMonitor Closely (1)lofexidine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. furosemideSerious - Use Alternative (1)lofexidine, furosemide. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.gadobenateMonitor Closely (1)gadobenate and lofexidine both increase QTc interval. Use Caution/Monitor.gemifloxacinSerious - Use Alternative (1)gemifloxacin and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.gilteritinibSerious - Use Alternative (1)gilteritinib and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.glasdegibSerious - Use Alternative (1)lofexidine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.granisetronSerious - Use Alternative (1)granisetron and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.guanfacineSerious - Use Alternative (1)lofexidine, guanfacine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.haloperidolMonitor Closely (1)haloperidol and lofexidine both increase sedation. Use Caution/Monitor.hydralazineSerious - Use Alternative (1)lofexidine, hydralazine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.hydrochlorothiazideSerious - Use Alternative (1)lofexidine, hydrochlorothiazide. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.hydromorphoneMonitor Closely (1)hydromorphone and lofexidine both increase sedation. Use Caution/Monitor.hydroxychloroquine sulfateSerious - Use Alternative (1)hydroxychloroquine sulfate and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzineMonitor Closely (1)hydroxyzine and lofexidine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)hydroxyzine and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.ibutilideMonitor Closely (1)ibutilide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.iloperidoneMonitor Closely (2)iloperidone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended. iloperidone and lofexidine both increase sedation. Use Caution/Monitor.iloprostSerious - Use Alternative (1)lofexidine, iloprost. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.imipramineMonitor Closely (2)imipramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. imipramine and lofexidine both increase sedation. Use Caution/Monitor.indapamideSerious - Use Alternative (1)lofexidine, indapamide. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.irbesartanSerious - Use Alternative (1)lofexidine, irbesartan. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.isofluraneSerious - Use Alternative (1)isoflurane and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.isoproterenolMonitor Closely (1)lofexidine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.isosorbide dinitrateSerious - Use Alternative (1)lofexidine, isosorbide dinitrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.isosorbide mononitrateSerious - Use Alternative (1)lofexidine, isosorbide mononitrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.isradipineSerious - Use Alternative (1)lofexidine, isradipine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.itraconazoleSerious - Use Alternative (1)itraconazole and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibSerious - Use Alternative (1)ivosidenib and lofexidine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketamineMonitor Closely (1)ketamine and lofexidine both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicMonitor Closely (1)ketotifen, ophthalmic and lofexidine both increase sedation. Use Caution/Monitor.labetalolSerious - Use Alternative (1)lofexidine, labetalol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.lefamulinSerious - Use Alternative (1)lefamulin and lofexidine both increase QTc interval. Avoid or Use Alternate Drug.levalbuterolMonitor Closely (1)lofexidine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanolMonitor Closely (1)levorphanol and lofexidine both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)lofexidine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lisinoprilSerious - Use Alternative (1)lofexidine, lisinopril. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.lithiumMonitor Closely (1)lithium and lofexidine both increase QTc interval. Use Caution/Monitor.lofepramineMonitor Closely (2)lofepramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. lofepramine and lofexidine both increase sedation. Use Caution/Monitor.lopinavirMonitor Closely (1)lopinavir and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.loprazolamMonitor Closely (1)loprazolam and lofexidine both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam and lofexidine both increase sedation. Use Caution/Monitor.lorcaserinMonitor Closely (1)lorcaserin will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.lormetazepamMonitor Closely (1)lormetazepam and lofexidine both increase sedation. Use Caution/Monitor.losartanSerious - Use Alternative (1)lofexidine, losartan. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.loxapineMonitor Closely (1)loxapine and lofexidine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)loxapine inhaled and lofexidine both increase sedation. Use Caution/Monitor.lumefantrineMonitor Closely (1)lumefantrine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.maprotilineMonitor Closely (2)maprotiline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. maprotiline and lofexidine both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)lofexidine and marijuana both increase sedation. Use Caution/Monitor.mecamylamineSerious - Use Alternative (1)lofexidine, mecamylamine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.melatoninMonitor Closely (1)lofexidine and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)meperidine and lofexidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)lofexidine and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)lofexidine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)metaxalone and lofexidine both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (2)methadone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended. methadone and lofexidine both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)lofexidine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)methocarbamol and lofexidine both increase sedation. Use Caution/Monitor.methyclothiazideSerious - Use Alternative (1)lofexidine, methyclothiazide. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.methyldopaSerious - Use Alternative (1)lofexidine, methyldopa. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.methylenedioxymethamphetamineMonitor Closely (1)lofexidine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metolazoneSerious - Use Alternative (1)lofexidine, metolazone. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.metoprololSerious - Use Alternative (1)lofexidine, metoprolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.metyrosineSerious - Use Alternative (1)lofexidine, metyrosine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.midazolamMonitor Closely (1)midazolam and lofexidine both increase sedation. Use Caution/Monitor.midodrineMonitor Closely (1)lofexidine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristoneMonitor Closely (1)mifepristone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.minoxidilSerious - Use Alternative (1)lofexidine, minoxidil. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.mirabegronMonitor Closely (1)mirabegron will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.mirtazapineMonitor Closely (2)mirtazapine and lofexidine both increase QTc interval. Use Caution/Monitor. lofexidine and mirtazapine both increase sedation. Use Caution/Monitor.mobocertinibSerious - Use Alternative (1)mobocertinib and lofexidine both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.modafinilMonitor Closely (1)lofexidine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.moexiprilSerious - Use Alternative (1)lofexidine, moexipril. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.morphineMonitor Closely (1)morphine and lofexidine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)lofexidine and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinMonitor Closely (1)moxifloxacin and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.moxonidineMonitor Closely (1)lofexidine and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)lofexidine and nabilone both increase sedation. Use Caution/Monitor.nadololSerious - Use Alternative (1)lofexidine, nadolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.nalbuphineMonitor Closely (1)nalbuphine and lofexidine both increase sedation. Use Caution/Monitor.naltrexoneMonitor Closely (1)lofexidine will decrease the level or effect of naltrexone by unknown mechanism. Modify Therapy/Monitor Closely. Coadministration of lofexidine with oral naltrexone resulted in statistically significant differences in the steady-state pharmacokinetics of naltrexone. The efficacy of oral naltrexone may be reduced if administered within 2 hours of taking lofexidine. Interaction not expected with other naltrexone routes of administration.nebivololSerious - Use Alternative (1)lofexidine, nebivolol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.nicardipineSerious - Use Alternative (1)lofexidine, nicardipine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.nifedipineSerious - Use Alternative (1)lofexidine, nifedipine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.nilotinibMonitor Closely (1)nilotinib and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.nimodipineSerious - Use Alternative (1)lofexidine, nimodipine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.nisoldipineSerious -