AdultPediatricGeriatricDosage Forms & Strengths capsule: Schedule IV 10mg 15mg 30mg Anxiety Mild/moderate: 10-15 mg PO q6-8hr PRN Severe, agitation or assoc with depression: 15-30 mg PO q6-8hr PRN Alcohol Withdrawal 15-30 mg PO q6-8hr PRNDosage Forms & Strengths capsule: Schedule IV 10mg 15mg 30mg Anxiety <6 years: Not recommended 6-12 years: Not established; use with caution >12 years Mild/moderate: 10-15 mg PO q6-8hr PRN Severe, agitation or assoc with depression: 15-30 mg PO q6-8hr PRN Drug of choice in elderly when benzodiazepine indicated because of short half-life Anxiety 10 mg q8-12hr; may gradually increase to total dose of 30-45 mg/day PRN Ethanol Withdrawal 10-30 mg PO q8-12hr PRNInteraction CheckerEnter a drug name and oxazepamNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (12)benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzhydrocodone/acetaminophen and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine subdermal implantbuprenorphine subdermal implant and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalbuprenorphine transdermal and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionbuprenorphine, long-acting injection and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatecalcium/magnesium/potassium/sodium oxybatesoxazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydrocodonehydrocodone, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.metoclopramide intranasaloxazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.olopatadine intranasaloxazepam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. selinexorselinexor, oxazepam. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sodium oxybateoxazepam, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.sufentanil SLsufentanil SL, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.valerianvalerian and oxazepam both increase sedation. Avoid or Use Alternate Drug.Monitor Closely (201)acrivastineacrivastine and oxazepam both increase sedation. Use Caution/Monitor.albuteroloxazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentaniloxazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamalprazolam and oxazepam both increase sedation. Use Caution/Monitor.amisulprideamisulpride and oxazepam both increase sedation. Use Caution/Monitor.amitriptylineoxazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and oxazepam both increase sedation. Use Caution/Monitor.amoxapineoxazepam and amoxapine both increase sedation. Use Caution/Monitor.apomorphineoxazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoteroloxazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleoxazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafiniloxazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineasenapine and oxazepam both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and oxazepam both increase sedation. Use Caution/Monitor.avapritinibavapritinib and oxazepam both increase sedation. Use Caution/Monitor.azelastineazelastine and oxazepam both increase sedation. Use Caution/Monitor.baclofenoxazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumoxazepam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidoloxazepam and benperidol both increase sedation. Use Caution/Monitor.benzphetamineoxazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanolonebrexanolone, oxazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and oxazepam both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and oxazepam both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and oxazepam both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and oxazepam both increase sedation. Use Caution/Monitor.buprenorphineoxazepam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccaloxazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantoxazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.buprenorphine, long-acting injectionoxazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.butabarbitalbutabarbital and oxazepam both increase sedation. Use Caution/Monitor.butalbitalbutalbital and oxazepam both increase sedation. Use Caution/Monitor.butorphanoloxazepam and butorphanol both increase sedation. Use Caution/Monitor.caffeineoxazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and oxazepam both increase sedation. Use Caution/Monitor.carisoprodoloxazepam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamatecenobamate, oxazepam. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateoxazepam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and oxazepam both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and oxazepam both increase sedation. Use Caution/Monitor.chlorpromazineoxazepam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneoxazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizinecinnarizine and oxazepam both increase sedation. Use Caution/Monitor.clemastineclemastine and oxazepam both increase sedation. Use Caution/Monitor.clobazamoxazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineoxazepam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and oxazepam both increase sedation. Use Caution/Monitor.clonidineclonidine, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateclorazepate and oxazepam both increase sedation. Use Caution/Monitor.clozapineoxazepam and clozapine both increase sedation. Use Caution/Monitor.codeineoxazepam and codeine both increase sedation. Use Caution/Monitor.cyclizinecyclizine and oxazepam both increase sedation. Use Caution/Monitor.cyclobenzaprineoxazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and oxazepam both increase sedation. Use Caution/Monitor.dantroleneoxazepam and dantrolene both increase sedation. Use Caution/Monitor.daridorexantoxazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluranedesflurane and oxazepam both increase sedation. Use Caution/Monitor.desipramineoxazepam and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineoxazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine and oxazepam both increase sedation. Use Caution/Monitor.dexfenfluramineoxazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineoxazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateoxazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineoxazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideoxazepam and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineoxazepam and diamorphine both increase sedation. Use Caution/Monitor.diazepamdiazepam and oxazepam both increase sedation. Use Caution/Monitor.diazepam intranasaldiazepam intranasal, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionoxazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalindifelikefalin and oxazepam both increase sedation. Use Caution/Monitor.difenoxin hcloxazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and oxazepam both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and oxazepam both increase sedation. Use Caution/Monitor.diphenoxylate hcloxazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneoxazepam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineoxazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineoxazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineoxazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinoxazepam and dosulepin both increase sedation. Use Caution/Monitor.doxepinoxazepam and doxepin both increase sedation. Use Caution/Monitor.doxylamineoxazepam and doxylamine both increase sedation. Use Caution/Monitor.droperidoloxazepam and droperidol both increase sedation. Use Caution/Monitor.ephedrineoxazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineoxazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicoxazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalesketamine intranasal, oxazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and oxazepam both increase sedation. Use Caution/Monitor.ethanoloxazepam and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and oxazepam both increase sedation. Use Caution/Monitor.fenfluramineoxazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flibanserinoxazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineoxazepam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and oxazepam both increase sedation. Use Caution/Monitor.formoteroloxazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentingabapentin, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneoxazepam and ganaxolone both increase sedation. Use Caution/Monitor.haloperidoloxazepam and haloperidol both increase sedation. Use Caution/Monitor.hyaluronidasehyaluronidase, oxazepam. Other (see comment). Use Caution/Monitor. Comment: Drug combination has been found to be incompatible.hydromorphoneoxazepam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and oxazepam both increase sedation. Use Caution/Monitor.iloperidoneoxazepam and iloperidone both increase sedation. Use Caution/Monitor.imipramineoxazepam and imipramine both increase sedation. Use Caution/Monitor.isoproterenoloxazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineketamine and oxazepam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicoxazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanlasmiditan, oxazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantlemborexant, oxazepam. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.levalbuteroloxazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanoloxazepam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineoxazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineoxazepam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineoxazepam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamloprazolam and oxazepam both increase sedation. Use Caution/Monitor.lorazepamlorazepam and oxazepam both increase sedation. Use Caution/Monitor.lormetazepamlormetazepam and oxazepam both increase sedation. Use Caution/Monitor.loxapineoxazepam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledoxazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, oxazepam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased