Alternate Drug.asenapineMonitor Closely (1)asenapine will increase the level or effect of atomoxetine by Other (see comment). Use Caution/Monitor. Potential for enhanced CNS depression. Monitor closely during conurrent use.Serious - Use Alternative (1)atomoxetine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalSerious - Use Alternative (1)asenapine transdermal and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.azithromycinSerious - Use Alternative (1)atomoxetine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.bedaquilineSerious - Use Alternative (1)atomoxetine and bedaquiline both increase QTc interval. Avoid or Use Alternate Drug.buprenorphineSerious - Use Alternative (1)atomoxetine and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalSerious - Use Alternative (1)buprenorphine buccal and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantSerious - Use Alternative (1)buprenorphine subdermal implant and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionSerious - Use Alternative (1)buprenorphine, long-acting injection and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.bupropionMonitor Closely (1)bupropion will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.celecoxibMonitor Closely (1)celecoxib will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.chloroquineMonitor Closely (1)chloroquine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)atomoxetine and chloroquine both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazineSerious - Use Alternative (1)atomoxetine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.cimetidineMonitor Closely (1)cimetidine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.ciprofloxacinMonitor Closely (1)atomoxetine and ciprofloxacin both increase QTc interval. Use Caution/Monitor.cisaprideContraindicated (1)atomoxetine and cisapride both increase QTc interval. Contraindicated.citalopramMonitor Closely (2)citalopram increases levels of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Although citalopram is a weak inhibitor of 2D6, the potential for an interaction exists. atomoxetine and citalopram both increase QTc interval. Use Caution/Monitor.clarithromycinSerious - Use Alternative (1)atomoxetine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineMonitor Closely (2)clomipramine increases levels of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. atomoxetine and clomipramine both increase QTc interval. Use Caution/Monitor.clozapineMonitor Closely (1)atomoxetine and clozapine both increase QTc interval. Use Caution/Monitor.crizotinibSerious - Use Alternative (1)atomoxetine and crizotinib both increase QTc interval. Avoid or Use Alternate Drug.dacomitinibSerious - Use Alternative (1)dacomitinib will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. darifenacinMonitor Closely (1)darifenacin will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.dasatinibMonitor Closely (1)atomoxetine and dasatinib both increase QTc interval. Use Caution/Monitor.degarelixMonitor Closely (1)atomoxetine and degarelix both increase QTc interval. Use Caution/Monitor.desfluraneSerious - Use Alternative (1)desflurane and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.desipramineMonitor Closely (1)atomoxetine and desipramine both increase QTc interval. Use Caution/Monitor.desvenlafaxineMonitor Closely (1)desvenlafaxine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgdeutetrabenazineMonitor Closely (1)atomoxetine and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).diphenhydramineMonitor Closely (1)diphenhydramine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.disopyramideSerious - Use Alternative (1)atomoxetine and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dobutamineMonitor Closely (1)atomoxetine, dobutamine. Other (see comment). Use Caution/Monitor. Comment: Due to the potential for increases in blood pressure and heart rate, atomoxetine should be used cautiously with vasopressors such as dobutamine.dofetilideSerious - Use Alternative (1)atomoxetine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetronMonitor Closely (1)atomoxetine and dolasetron both increase QTc interval. Use Caution/Monitor.donepezilMonitor Closely (1)donepezil and atomoxetine both increase QTc interval. Use Caution/Monitor.dopamineMonitor Closely (1)atomoxetine, dopamine. Other (see comment). Use Caution/Monitor. Comment: Due to the potential for increases in blood pressure and heart rate, atomoxetine should be used cautiously with vasopressors such as dopamine.doxepinMonitor Closely (1)doxepin and atomoxetine both increase QTc interval. Use Caution/Monitor.dronedaroneContraindicated (1)atomoxetine and dronedarone both increase QTc interval. Contraindicated.Monitor Closely (1)dronedarone will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.droperidolSerious - Use Alternative (1)atomoxetine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineMonitor Closely (1)duloxetine increases levels of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.efavirenzMonitor Closely (1)efavirenz and atomoxetine both increase QTc interval. Use Caution/Monitor.eliglustatMonitor Closely (2)atomoxetine and eliglustat both increase QTc interval. Use Caution/Monitor. eliglustat increases levels of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.elvitegravir/cobicistat/emtricitabine/tenofovir DFMonitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.encorafenibSerious - Use Alternative (1)atomoxetine and encorafenib both increase QTc interval. Avoid or Use Alternate Drug.entrectinibSerious - Use Alternative (1)atomoxetine and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.ephedrineMonitor Closely (1)atomoxetine, ephedrine. Other (see comment). Use Caution/Monitor. Comment: Due to the potential for increases in blood pressure and heart rate, atomoxetine should be used cautiously.epinephrineMonitor Closely (1)atomoxetine, epinephrine. Other (see comment). Use Caution/Monitor. Comment: Due to the potential for increases in blood pressure and heart rate, atomoxetine should be used cautiously with vasopressors such as epinephrine.epinephrine inhaledMonitor Closely (1)atomoxetine, epinephrine inhaled. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.eribulinSerious - Use Alternative (1)eribulin and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseSerious - Use Alternative (1)atomoxetine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)atomoxetine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)atomoxetine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)atomoxetine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramMonitor Closely (2)atomoxetine and escitalopram both increase QTc interval. Use Caution/Monitor. escitalopram increases levels of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)esketamine intranasal, atomoxetine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .fedratinibMonitor Closely (1)fedratinib will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary.fexinidazoleSerious - Use Alternative (1)fexinidazole and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fingolimodMonitor Closely (1)fingolimod and atomoxetine both increase QTc interval. Use Caution/Monitor.flecainideSerious - Use Alternative (1)atomoxetine and flecainide both increase QTc interval. Avoid or Use Alternate Drug.fluconazoleMonitor Closely (1)atomoxetine and fluconazole both increase QTc interval. Use Caution/Monitor.fluoxetineMonitor Closely (1)fluoxetine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Reduced initial doses of atomoxetine are recommended with strong CYP2D6 inhibitors.Serious - Use Alternative (1)atomoxetine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.fluphenazineMonitor Closely (1)atomoxetine and fluphenazine both increase QTc interval. Use Caution/Monitor.formoterolMonitor Closely (2)atomoxetine and formoterol both increase QTc interval. Use Caution/Monitor. formoterol, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .foscarnetSerious - Use Alternative (1)atomoxetine and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.fostemsavirMonitor Closely (1)atomoxetine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. gemifloxacinMonitor Closely (1)atomoxetine and gemifloxacin both increase QTc interval. Use Caution/Monitor.gemtuzumabMonitor Closely (1)atomoxetine and gemtuzumab both increase QTc interval. Use Caution/Monitor.gilteritinibMonitor Closely (1)atomoxetine and gilteritinib both increase QTc interval. Use Caution/Monitor.givosiranSerious - Use Alternative (1)givosiran will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.glasdegibSerious - Use Alternative (1)atomoxetine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.goserelinMonitor Closely (1)atomoxetine and goserelin both increase QTc interval. Use Caution/Monitor.granisetronMonitor Closely (1)atomoxetine and granisetron both increase QTc interval. Use Caution/Monitor.haloperidolMonitor Closely (2)atomoxetine and haloperidol both increase QTc interval. Use Caution/Monitor. haloperidol will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.histrelinMonitor Closely (1)atomoxetine and histrelin both increase QTc interval. Use Caution/Monitor.hydroxychloroquine sulfateSerious - Use Alternative (1)atomoxetine and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzineMonitor Closely (1)atomoxetine and hydroxyzine both increase QTc interval. Use Caution/Monitor.ibutilideSerious - Use Alternative (1)atomoxetine and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.iloperidoneSerious - Use Alternative (1)atomoxetine and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.imatinibMonitor Closely (1)imatinib will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.indacaterol, inhaledMonitor Closely (1)atomoxetine and indacaterol, inhaled both increase QTc interval. Use Caution/Monitor.inotuzumabSerious - Use Alternative (1)atomoxetine and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.iobenguane I 123Contraindicated (1)atomoxetine decreases effects of iobenguane I 123 by receptor binding competition. Contraindicated. If clinically appropriate, discontinue drugs that compete for NE receptor sites for at least 5 half-lives; may cause false-negative imaging results.iobenguane I 131Serious - Use Alternative (1)atomoxetine will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.isocarboxazidContraindicated (1)isocarboxazid increases effects of atomoxetine by pharmacodynamic synergism. Contraindicated. The use of atomoxetine with monoamine oxidase inhibitors (MAOIs) is contraindicated. Risk of acute hypertensive episode.isofluraneSerious - Use Alternative (1)atomoxetine and isoflurane both increase QTc interval. Avoid or Use Alternate Drug.itraconazoleMonitor Closely (1)atomoxetine and itraconazole both increase QTc interval. Use Caution/Monitor.ivosidenibSerious - Use Alternative (1)atomoxetine and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.lapatinibMonitor Closely (1)atomoxetine and lapatinib both increase QTc interval. Use Caution/Monitor.lefamulinSerious - Use Alternative (1)lefamulin and atomoxetine both increase QTc interval. Avoid or Use Alternate Drug.lenvatinibSerious - Use Alternative (1)atomoxetine and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.leuprolideMonitor Closely (1)atomoxetine and leuprolide both increase QTc interval. Use Caution/Monitor.levalbuterolMonitor Closely (2)levalbuterol, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. . atomoxetine and levalbuterol both increase QTc interval. Use Caution/Monitor.levofloxacinMonitor Closely (1)atomoxetine and levofloxacin both increase QTc interval. Use Caution/Monitor.linezolidContraindicated (1)linezolid increases effects of atomoxetine by pharmacodynamic synergism. Contraindicated. The use of atomoxetine with monoamine oxidase inhibitors (MAOIs) is contraindicated. Risk of acute hypertensive episode.lithiumMonitor Closely (1)atomoxetine and lithium both increase QTc interval. Use Caution/Monitor.lofexidineMonitor Closely (1)atomoxetine and lofexidine both increase QTc interval. Use Caution/Monitor.loperamideMonitor Closely (1)atomoxetine and loperamide both increase QTc interval. Use Caution/Monitor.lopinavirSerious - Use Alternative (1)atomoxetine and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.lorcaserinMonitor Closely (1)lorcaserin will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.lumefantrineMonitor Closely (1)lumefantrine will increase the level or effect of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, atomoxetine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse