neuroleptic malignant syndrome.Monitor Closely (1)fluphenazine and amisulpride both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.amitriptylineMonitor Closely (1)fluphenazine and amitriptyline both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)fluphenazine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)amitriptyline, fluphenazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects. amitriptyline, fluphenazine. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.amobarbitalMonitor Closely (1)amobarbital and fluphenazine both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (2)fluphenazine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely. fluphenazine and amoxapine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)fluphenazine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.Minor (3)amoxapine, fluphenazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects. amoxapine, fluphenazine. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects. fluphenazine, amoxapine. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.anagrelideMonitor Closely (1)anagrelide and fluphenazine both increase QTc interval. Use Caution/Monitor.anticholinergic/sedative combosMonitor Closely (3)anticholinergic/sedative combos decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. anticholinergic/sedative combos decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.apomorphineMonitor Closely (1)fluphenazine and apomorphine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)fluphenazine decreases effects of apomorphine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. apomorphine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.arformoterolMonitor Closely (2)fluphenazine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and fluphenazine both increase QTc interval. Use Caution/Monitor.aripiprazoleMonitor Closely (2)aripiprazole and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. aripiprazole and fluphenazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)aripiprazole and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.armodafinilMonitor Closely (1)fluphenazine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arsenic trioxideSerious - Use Alternative (1)fluphenazine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherMonitor Closely (1)artemether and fluphenazine both increase QTc interval. Use Caution/Monitor.artemether/lumefantrineMonitor Closely (1)artemether/lumefantrine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)fluphenazine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.asenapineMonitor Closely (2)asenapine and fluphenazine both increase QTc interval. Use Caution/Monitor. asenapine and fluphenazine both increase sedation. Use Caution/Monitor.Minor (1)asenapine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.asenapine transdermalMonitor Closely (2)asenapine transdermal and fluphenazine both increase QTc interval. Use Caution/Monitor. asenapine transdermal and fluphenazine both increase sedation. Use Caution/Monitor.atomoxetineMonitor Closely (1)atomoxetine and fluphenazine both increase QTc interval. Use Caution/Monitor.atracuriumMonitor Closely (3)atracurium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. atracurium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of atracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropineMonitor Closely (3)atropine decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. atropine decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of atropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.Minor (1)fluphenazine increases toxicity of atropine by unknown mechanism. Minor/Significance Unknown.atropine IV/IMMonitor Closely (3)fluphenazine increases effects of atropine IV/IM by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. atropine IV/IM decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. atropine IV/IM decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.Minor (1)fluphenazine increases toxicity of atropine IV/IM by unknown mechanism. Minor/Significance Unknown.avapritinibMonitor Closely (1)avapritinib and fluphenazine both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and fluphenazine both increase sedation. Use Caution/Monitor.azithromycinMonitor Closely (1)fluphenazine and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenMonitor Closely (1)baclofen and fluphenazine both increase sedation. Use Caution/Monitor.bedaquilineMonitor Closely (1)fluphenazine and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsMonitor Closely (3)belladonna alkaloids decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. belladonna alkaloids decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of belladonna alkaloids by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.belladonna and opiumMonitor Closely (4)belladonna and opium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. belladonna and opium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of belladonna and opium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. belladonna and opium and fluphenazine both increase sedation. Use Caution/Monitor.benazeprilMinor (1)fluphenazine increases effects of benazepril by unspecified interaction mechanism. Minor/Significance Unknown. Enhanced hypotensive effects.benperidolMonitor Closely (2)benperidol and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. benperidol and fluphenazine both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenMonitor Closely (1)benzhydrocodone/acetaminophen and fluphenazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)benzhydrocodone/acetaminophen, fluphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).benzphetamineMonitor Closely (2)fluphenazine, benzphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. fluphenazine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benztropineMonitor Closely (1)fluphenazine increases effects of benztropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. .brexanoloneMonitor Closely (1)brexanolone, fluphenazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and fluphenazine both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and fluphenazine both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of fluphenazine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and fluphenazine both increase sedation. Use Caution/Monitor.bromocriptineSerious - Use Alternative (1)fluphenazine decreases effects of bromocriptine by pharmacodynamic antagonism. Avoid or Use Alternate Drug.brompheniramineMonitor Closely (1)brompheniramine and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (2)buprenorphine and fluphenazine both increase QTc interval. Use Caution/Monitor. buprenorphine and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (2)buprenorphine buccal and fluphenazine both increase QTc interval. Use Caution/Monitor. buprenorphine buccal and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (2)buprenorphine subdermal implant and fluphenazine both increase QTc interval. Use Caution/Monitor. buprenorphine subdermal implant and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine transdermalMonitor Closely (2)buprenorphine transdermal and fluphenazine both increase QTc interval. Use Caution/Monitor. buprenorphine transdermal and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionMonitor Closely (3)buprenorphine, long-acting injection and fluphenazine both increase QTc interval. Use Caution/Monitor. fluphenazine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. buprenorphine, long-acting injection and fluphenazine both increase sedation. Use Caution/Monitor.bupropionMonitor Closely (1)bupropion will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Minor (1)fluphenazine increases toxicity of bupropion by unspecified interaction mechanism. Minor/Significance Unknown. May lower seizure threshold; keep bupropion dose as low as possible.butabarbitalMonitor Closely (1)butabarbital and fluphenazine both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and fluphenazine both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol and fluphenazine both increase sedation. Use Caution/Monitor.cabergolineSerious - Use Alternative (1)fluphenazine decreases effects of cabergoline by pharmacodynamic antagonism. Contraindicated.caffeineMonitor Closely (1)fluphenazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)fluphenazine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.captoprilMinor (1)fluphenazine increases effects of captopril by unspecified interaction mechanism. Minor/Significance Unknown. Both drugs lower blood pressure. Monitor blood pressure.carbinoxamineMonitor Closely (1)carbinoxamine and fluphenazine both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)carisoprodol and fluphenazine both increase sedation. Use Caution/Monitor.celecoxibMinor (1)celecoxib will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.ceritinibMonitor Closely (1)ceritinib and fluphenazine both increase QTc interval. Use Caution/Monitor.chasteberryMinor (1)chasteberry decreases effects of fluphenazine by pharmacodynamic antagonism. Minor/Significance Unknown. (Theoretical interaction).chloral hydrateMonitor Closely (1)chloral hydrate and fluphenazine both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and fluphenazine both increase sedation. Use Caution/Monitor.chloroquineMinor (3)chloroquine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. chloroquine increases levels of fluphenazine by decreasing metabolism. Minor/Significance Unknown. chloroquine increases toxicity of fluphenazine by QTc interval. Minor/Significance Unknown.chlorpheniramineMonitor Closely (1)chlorpheniramine and fluphenazine both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (2)chlorpromazine and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. chlorpromazine and fluphenazine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.chlorzoxazoneMonitor Closely (1)chlorzoxazone and fluphenazine both increase sedation. Use Caution/Monitor.cigarette smokingMonitor Closely (1)cigarette smoking decreases levels of fluphenazine by increasing metabolism. Use Caution/Monitor. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines.cimetidineMinor (1)cimetidine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.cinnarizineMonitor Closely (1)cinnarizine and fluphenazine both increase sedation. Use Caution/Monitor.cisatracuriumMonitor Closely (3)cisatracurium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. cisatracurium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of cisatracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.citalopramMonitor Closely (1)citalopram and fluphenazine both increase QTc interval. Use Caution/Monitor.clarithromycinSerious - Use Alternative (1)fluphenazine and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clemastineMonitor Closely (1)clemastine and fluphenazine both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (2)clobazam will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. fluphenazine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)fluphenazine and clomipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)fluphenazine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)clomipramine, fluphenazine. Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects. clomipramine, fluphenazine. Either increases levels of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.clonazepamMonitor Closely (1)clonazepam and fluphenazine both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, fluphenazine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Additive hypotensive effects; potential delirium.clorazepateMonitor Closely (1)clorazepate and fluphenazine both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (3)clozapine and fluphenazine both increase QTc interval. Use Caution/Monitor. clozapine and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. clozapine and fluphenazine both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)codeine and fluphenazine both increase sedation. Use Caution/Monitor.crizotinibMonitor Closely (1)crizotinib and fluphenazine both increase QTc interval. Use Caution/Monitor.cyclizineMonitor Closely (4)cyclizine decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. cyclizine decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. cyclizine and fluphenazine both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (4)cyclobenzaprine decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. cyclobenzaprine decreases levels of fluphenazine by pharmacodynamic antagonism. Use