both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.levofloxacinMonitor Closely (1)arformoterol and levofloxacin both increase QTc interval. Use Caution/Monitor.levorphanolMonitor Closely (1)levorphanol increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.linezolidSerious - Use Alternative (1)linezolid increases effects of arformoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lisdexamfetamineMonitor Closely (2)arformoterol and lisdexamfetamine both decrease sedation. Use Caution/Monitor. arformoterol and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.lithiumMonitor Closely (1)arformoterol and lithium both increase QTc interval. Use Caution/Monitor.lofepramineMonitor Closely (1)lofepramine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)lofepramine, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lofexidineMonitor Closely (2)arformoterol and lofexidine both increase QTc interval. Use Caution/Monitor. lofexidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loperamideMonitor Closely (1)arformoterol and loperamide both increase QTc interval. Use Caution/Monitor.lopinavirSerious - Use Alternative (1)arformoterol and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.loprazolamMonitor Closely (1)loprazolam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lormetazepamMonitor Closely (1)lormetazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lornoxicamMonitor Closely (1)lornoxicam increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapineMonitor Closely (1)loxapine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)loxapine inhaled increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.macimorelinSerious - Use Alternative (1)macimorelin and arformoterol both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilineMonitor Closely (2)maprotiline increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and maprotiline both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)maprotiline, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.marijuanaMonitor Closely (1)marijuana increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meclofenamateMonitor Closely (1)meclofenamate increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.mefenamic acidMonitor Closely (1)mefenamic acid increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.mefloquineMonitor Closely (1)arformoterol and mefloquine both increase QTc interval. Use Caution/Monitor.melatoninMonitor Closely (1)melatonin increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meloxicamMonitor Closely (1)meloxicam increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.meperidineMonitor Closely (1)meperidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meprobamateMonitor Closely (1)meprobamate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaproterenolMonitor Closely (3)arformoterol and metaproterenol both decrease serum potassium. Use Caution/Monitor. arformoterol and metaproterenol both decrease sedation. Use Caution/Monitor. arformoterol and metaproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methadoneMonitor Closely (2)methadone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and methadone both increase QTc interval. Use Caution/Monitor.methamphetamineMonitor Closely (2)arformoterol and methamphetamine both decrease sedation. Use Caution/Monitor. arformoterol and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methyclothiazideMonitor Closely (1)arformoterol and methyclothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)arformoterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.methylenedioxymethamphetamineMonitor Closely (2)arformoterol and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor. arformoterol and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methylphenidateMonitor Closely (1)arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.metolazoneMonitor Closely (1)arformoterol and metolazone both decrease serum potassium. Use Caution/Monitor.Minor (1)arformoterol, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.metoprololMonitor Closely (2)metoprolol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor. metoprolol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolamMonitor Closely (1)midazolam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midodrineMonitor Closely (2)arformoterol and midodrine both decrease sedation. Use Caution/Monitor. arformoterol and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.midostaurinMonitor Closely (1)arformoterol and midostaurin both increase QTc interval. Use Caution/Monitor.mifepristoneMonitor Closely (1)mifepristone, arformoterol. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.mirtazapineMonitor Closely (2)mirtazapine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and mirtazapine both increase QTc interval. Use Caution/Monitor.mobocertinibSerious - Use Alternative (1)mobocertinib and arformoterol both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.modafinilMonitor Closely (1)arformoterol and modafinil both decrease sedation. Use Caution/Monitor.morphineMonitor Closely (1)morphine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.motherwortMonitor Closely (1)motherwort increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.moxifloxacinMonitor Closely (1)arformoterol and moxifloxacin both increase QTc interval. Use Caution/Monitor.moxonidineMonitor Closely (1)moxonidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabiloneMonitor Closely (1)nabilone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabumetoneMonitor Closely (1)nabumetone increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nadololMonitor Closely (2)nadolol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor. nadolol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nalbuphineMonitor Closely (1)nalbuphine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.naproxenMonitor Closely (1)naproxen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nebivololMonitor Closely (2)nebivolol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor. nebivolol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.nilotinibMonitor Closely (1)arformoterol and nilotinib both increase QTc interval. Use Caution/Monitor.noni juiceMinor (1)noni juice increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.norepinephrineMonitor Closely (3)arformoterol and norepinephrine both decrease serum potassium. Use Caution/Monitor. arformoterol and norepinephrine both decrease sedation. Use Caution/Monitor. arformoterol and norepinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.nortriptylineMonitor Closely (2)arformoterol and nortriptyline both increase QTc interval. Use Caution/Monitor. nortriptyline increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)nortriptyline, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.octreotideMonitor Closely (1)arformoterol and octreotide both increase QTc interval. Use Caution/Monitor.ofloxacinMonitor Closely (1)arformoterol and ofloxacin both increase QTc interval. Use Caution/Monitor.olanzapineMonitor Closely (2)arformoterol and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances olanzapine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.olodaterol inhaledMonitor Closely (2)arformoterol and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effects arformoterol and olodaterol inhaled both increase QTc interval. Use Caution/Monitor.ondansetronSerious - Use Alternative (1)arformoterol and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.opium tinctureMonitor Closely (1)opium tincture increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.osilodrostatMonitor Closely (1)osilodrostat and arformoterol both increase QTc interval. Use Caution/Monitor.osimertinibMonitor Closely (1)osimertinib and arformoterol both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.oxaliplatinMonitor Closely (2)oxaliplatin will increase the level or effect of arformoterol by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval. arformoterol and oxaliplatin both increase QTc interval. Use Caution/Monitor.oxaprozinMonitor Closely (1)oxaprozin increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxazepamMonitor Closely (1)oxazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxycodoneMonitor Closely (1)oxycodone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxymorphoneMonitor Closely (1)oxymorphone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ozanimodMonitor Closely (1)ozanimod and arformoterol both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidoneMonitor Closely (2)paliperidone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. arformoterol and paliperidone both increase QTc interval. Use Caution/Monitor.panobinostatSerious - Use Alternative (1)arformoterol and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.papaveretumMonitor Closely (1)papaveretum increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.papaverineMonitor Closely (1)papaverine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.parecoxibMonitor Closely (1)parecoxib increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pasireotideMonitor Closely (1)arformoterol and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.pazopanibMonitor Closely (1)arformoterol and pazopanib both increase QTc interval. Use Caution/Monitor.penbutololMonitor Closely (2)penbutolol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor. penbutolol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pentazocineMonitor Closely (1)pentazocine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.perphenazineMonitor Closely (2)arformoterol and perphenazine both increase QTc interval. Use Caution/Monitor. perphenazine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phendimetrazineMonitor Closely (2)arformoterol and phendimetrazine both decrease sedation. Use Caution/Monitor. arformoterol and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenelzineSerious - Use Alternative (1)phenelzine increases effects of arformoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.phenobarbitalMonitor Closely (1)phenobarbital increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenoxybenzamineMonitor Closely (1)phenoxybenzamine, arformoterol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Hypotension, tachycardia.phentermineMonitor Closely (2)arformoterol and phentermine both decrease sedation. Use Caution/Monitor. arformoterol and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrineMonitor Closely (2)arformoterol and phenylephrine both decrease sedation. Use Caution/Monitor. arformoterol and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrine POMonitor Closely (2)arformoterol and phenylephrine PO both decrease sedation. Use Caution/Monitor. arformoterol and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.pholcodineMonitor Closely (1)pholcodine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimavanserinMonitor Closely (1)arformoterol and pimavanserin both increase QTc interval. Use Caution/Monitor.pimozideMonitor Closely (1)pimozide increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)arformoterol and pimozide both increase QTc interval. Contraindicated.pindololMonitor Closely (2)pindolol decreases effects of arformoterol by pharmacodynamic antagonism. Use Caution/Monitor. pindolol increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pirbuterolMonitor Closely (3)arformoterol and pirbuterol both decrease serum potassium. Use Caution/Monitor. arformoterol and pirbuterol both decrease sedation. Use Caution/Monitor. arformoterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use