Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome.olanzapine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.fluoxetine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.fluoxetine will increase the level or effect of metoclopramide intranasal by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Concurrent use of metoclopramide intranasal and strong CYP2D6 inhibitors is not recommended since the metoclopramide intranasal dose cannot be adjusted.metoprololfluoxetine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.midostaurinolanzapine and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mexiletinefluoxetine will increase the level or effect of mexiletine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.milnacipranfluoxetine and milnacipran both increase serotonin levels. Avoid or Use Alternate Drug.mirtazapinemirtazapine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.mobocertinibmobocertinib and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.mobocertinib and olanzapine both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.morphinefluoxetine will increase the level or effect of morphine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.morphine, fluoxetine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.moxifloxacinolanzapine and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nebivololfluoxetine will increase the level or effect of nebivolol by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.nefazodonefluoxetine and nefazodone both increase serotonin levels. Avoid or Use Alternate Drug.netupitant/palonosetronnetupitant/palonosetron, fluoxetine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.nortriptylinefluoxetine will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluoxetine and nortriptyline both increase serotonin levels. Avoid or Use Alternate Drug.olopatadine intranasalolanzapine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. fluoxetine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronfluoxetine and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.ondansetron, fluoxetine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.olanzapine and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.oxaliplatinoxaliplatin and olanzapine both increase QTc interval. Avoid or Use Alternate Drug. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instancesolanzapine and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.oxaliplatin and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.oxycodoneoxycodone will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Opioids may enhance the serotonergic effects of SSRIs and increase risk for serotonergic syndromepaliperidoneolanzapine and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.oxymorphonefluoxetine will increase the level or effect of oxymorphone by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.ozanimodozanimod increases toxicity of fluoxetine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.palonosetronpalonosetron, fluoxetine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.panobinostatfluoxetine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.olanzapine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.paroxetinefluoxetine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.olanzapine and paroxetine both increase QTc interval. Avoid or Use Alternate Drug.fluoxetine and paroxetine both increase serotonin levels. Avoid or Use Alternate Drug.pazopanibolanzapine and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.pentamidinefluoxetine and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.pefloxacinpefloxacin will increase the level or effect of olanzapine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug.pentamidineolanzapine and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.perphenazinefluoxetine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.perphenazine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.perphenazine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.phenterminefluoxetine, phentermine. Either increases toxicity of the other by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of serotonin syndrome.pimavanserinolanzapine and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.pimozideolanzapine and pimozide both increase QTc interval. Contraindicated.pirfenidonefluoxetine will increase the level or effect of pirfenidone by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid; coadministration of pirfenidone and moderate CYP1A2 inhibitors result in moderately increased exposure to pirfenidone; if unable to avoid, decrease dose of moderate CYP1A2 inhibitorpitolisantolanzapine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.fluoxetine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodolanzapine and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.procainamidefluoxetine and procainamide both increase QTc interval. Avoid or Use Alternate Drug.pramipexoleolanzapine decreases effects of pramipexole by pharmacodynamic antagonism. Contraindicated.procainamideolanzapine and procainamide both increase QTc interval. Avoid or Use Alternate Drug.promethazinefluoxetine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.propafenonepropafenone will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluoxetine will increase the level or effect of propafenone by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.olanzapine and propafenone both increase QTc interval. Avoid or Use Alternate Drug.propafenone and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.propranololfluoxetine will increase the level or effect of propranolol by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.quetiapineolanzapine and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.protriptylinefluoxetine and protriptyline both increase serotonin levels. Avoid or Use Alternate Drug.quinidineolanzapine and quinidine both increase QTc interval. Avoid or Use Alternate Drug.quinidine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.quinidine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.ranolazineolanzapine and ranolazine both increase QTc interval. Avoid or Use Alternate Drug.rasagilinerasagiline and fluoxetine both increase serotonin levels. Avoid or Use Alternate Drug. evere CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. Avoid combination within 14 days of MAOI use.ribociclibribociclib increases toxicity of fluoxetine by QTc interval. Avoid or Use Alternate Drug.ribociclib will increase the level or effect of fluoxetine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.ribociclib increases toxicity of olanzapine by QTc interval. Avoid or Use Alternate Drug. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances.risperidonefluoxetine will increase the level or effect of risperidone by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.ropiniroleolanzapine decreases effects of ropinirole by pharmacodynamic antagonism. Contraindicated.safinamideolanzapine decreases effects of safinamide by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Dopamine antagonists may decrease safinamide effects and exacerbate Parkinson disease symptoms.saquinavirolanzapine and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.selegiline transdermalselegiline transdermal and fluoxetine both decrease serotonin levels. Avoid or Use Alternate Drug.selinexorselinexor, fluoxetine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.selinexor, olanzapine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.sertralinesertraline will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.fluoxetine and sertraline both increase serotonin levels. Avoid or Use Alternate Drug.sevofluranesevoflurane and olanzapine both increase QTc interval. Avoid or Use Alternate Drug. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instancessevofluranesevoflurane and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.siponimodsiponimod and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.olanzapine and siponimod both increase QTc interval. Avoid or Use Alternate Drug.olanzapine will increase the level or effect of siponimod by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Coadministration of siponimod with drugs that cause moderate CYP2C9 AND a moderate or strong CYP3A4 inhibition is not recommended. Caution if siponimod coadministered with moderate CYP2C9 inhibitors alone.sodium oxybateolanzapine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.St John's Wortfluoxetine and St John's Wort both increase serotonin levels. Avoid or Use Alternate Drug.sotalolfluoxetine and sotalol both increase QTc interval. Avoid or Use Alternate Drug.sotalololanzapine and sotalol both increase QTc interval. Avoid or Use Alternate Drug.sufentanil SLsufentanil SL, olanzapine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.tedizolidtedizolid, fluoxetine. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. both increase serotonin levels; increased risk of serotonin syndrome.tetrabenazineolanzapine and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.tetrabenazine and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.thioridazinefluoxetine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.thiothixeneolanzapine and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.timololfluoxetine will increase the level or effect of timolol by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.tipranavirtipranavir will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.tolterodinefluoxetine will increase the level or effect of tolterodine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.toremifeneolanzapine and toremifene both increase QTc interval. Avoid or Use Alternate Drug.trazodonefluoxetine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.olanzapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trimipraminefluoxetine and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.triptorelinolanzapine and triptorelin both increase QTc interval. Avoid or Use Alternate Drug.triptorelintriptorelin increases toxicity of fluoxetine by QTc interval. Avoid or Use Alternate Drug. Increases risk of torsades de pointes.umeclidinium bromide/vilanterol inhaledolanzapine increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vandetanibolanzapine and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.fluoxetine, vandetanib. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.vemurafenibolanzapine and vemurafenib both increase QTc interval. Avoid or Use Alternate