diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and estazolam both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)estazolam and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and estazolam both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and estazolam both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)estazolam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)estazolam and dipipanone both increase sedation. Use Caution/Monitor.dobutamineMonitor Closely (1)estazolam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)estazolam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)estazolam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)estazolam and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)estazolam and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)estazolam and doxylamine both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)estazolam and droperidol both increase sedation. Use Caution/Monitor.elvitegravir/cobicistat/emtricitabine/tenofovir DFMonitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of estazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.ephedrineMonitor Closely (1)estazolam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)estazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)estazolam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)esketamine intranasal, estazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.esomeprazoleMinor (1)esomeprazole will increase the level or effect of estazolam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.ethanolMonitor Closely (1)estazolam and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and estazolam both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)estazolam and eucalyptus both increase sedation. Minor/Significance Unknown.fenfluramineMonitor Closely (1)estazolam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fentanylSerious - Use Alternative (1)fentanyl, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalSerious - Use Alternative (1)fentanyl intranasal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalSerious - Use Alternative (1)fentanyl transdermal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalSerious - Use Alternative (1)fentanyl transmucosal, estazolam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fleroxacinMinor (1)fleroxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.flibanserinMonitor Closely (1)estazolam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineMonitor Closely (1)estazolam and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)estazolam and flurazepam both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)estazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentinMonitor Closely (1)gabapentin, estazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, estazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)estazolam and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacinMinor (1)gemifloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.haloperidolMonitor Closely (1)estazolam and haloperidol both increase sedation. Use Caution/Monitor.hydrocodoneSerious - Use Alternative (1)hydrocodone, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)estazolam and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and estazolam both increase sedation. Use Caution/Monitor.iloperidoneMonitor Closely (1)estazolam and iloperidone both increase sedation. Use Caution/Monitor.imipramineMonitor Closely (1)estazolam and imipramine both increase sedation. Use Caution/Monitor.isoproterenolMonitor Closely (1)estazolam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.itraconazoleContraindicated (1)itraconazole will increase the level or effect of estazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.ketamineMonitor Closely (1)ketamine and estazolam both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicMonitor Closely (1)estazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanMonitor Closely (1)lasmiditan, estazolam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantSerious - Use Alternative (1)lemborexant, estazolam. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.levalbuterolMonitor Closely (1)estazolam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levofloxacinMinor (1)levofloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.levorphanolMonitor Closely (1)estazolam and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)estazolam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineMonitor Closely (1)estazolam and lofepramine both increase sedation. Use Caution/Monitor.lofexidineMonitor Closely (1)estazolam and lofexidine both increase sedation. Use Caution/Monitor.loprazolamMonitor Closely (1)estazolam and loprazolam both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)estazolam and lorazepam both increase sedation. Use Caution/Monitor.lormetazepamMonitor Closely (1)estazolam and lormetazepam both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)estazolam and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)estazolam and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, estazolam. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineMonitor Closely (1)estazolam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)estazolam and marijuana both increase sedation. Use Caution/Monitor.melatoninMonitor Closely (1)estazolam and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)estazolam and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)estazolam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)estazolam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)estazolam and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)estazolam and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)estazolam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)estazolam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)estazolam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metoclopramide intranasalSerious - Use Alternative (1)estazolam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midazolamMonitor Closely (1)estazolam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasalMonitor Closely (1)midazolam intranasal, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineMonitor Closely (1)estazolam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineMonitor Closely (1)estazolam and mirtazapine both increase sedation. Use Caution/Monitor.modafinilMonitor Closely (1)estazolam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineMonitor Closely (1)estazolam and morphine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)estazolam and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinMinor (1)moxifloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.moxonidineMonitor Closely (1)estazolam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)estazolam and nabilone both increase sedation. Use Caution/Monitor.nalbuphineMonitor Closely (1)estazolam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrineMonitor Closely (1)estazolam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineMonitor Closely (1)estazolam and nortriptyline both increase sedation. Use Caution/Monitor.ofloxacinMinor (1)ofloxacin increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.olanzapineMonitor Closely (1)estazolam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (1)oliceridine, estazolam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olopatadine intranasalSerious - Use Alternative (1)estazolam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. omeprazoleMinor (1)omeprazole increases levels of estazolam by decreasing metabolism. Minor/Significance Unknown.opium tinctureMonitor Closely (1)estazolam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineMonitor Closely (1)estazolam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamMonitor Closely (1)estazolam and oxazepam both increase sedation. Use Caution/Monitor.oxycodoneMonitor Closely (1)estazolam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneMonitor Closely (1)estazolam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneMonitor Closely (1)estazolam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumMonitor Closely (1)estazolam and papaveretum both increase sedation. Use Caution/Monitor.papaverineMonitor Closely (1)estazolam and papaverine both increase sedation. Use Caution/Monitor.pentazocineMonitor Closely (1)estazolam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and estazolam both increase sedation. Use Caution/Monitor.perphenazineMonitor Closely (1)estazolam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineMonitor Closely (1)estazolam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (1)phenobarbital and estazolam both increase sedation. Use Caution/Monitor.phentermineMonitor Closely (1)estazolam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (1)estazolam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (1)estazolam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineMonitor Closely (1)estazolam and pholcodine both increase sedation. Use Caution/Monitor.pimozideMonitor Closely (1)estazolam and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)estazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinMonitor Closely (1)pregabalin, estazolam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneMonitor Closely (1)primidone and estazolam both increase sedation. Use Caution/Monitor.prochlorperazineMonitor Closely (1)estazolam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineMonitor Closely (1)promethazine and estazolam both increase sedation. Use Caution/Monitor.propofolMonitor Closely (1)propofol and estazolam both increase sedation. Use Caution/Monitor.propylhexedrineMonitor Closely (1)estazolam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)estazolam and protriptyline both increase sedation. Use Caution/Monitor.quazepamMonitor Closely (1)estazolam and quazepam both increase sedation. Use Caution/Monitor.quetiapineMonitor Closely (1)estazolam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonMonitor Closely (1)estazolam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamMonitor Closely (1)remimazolam, estazolam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.rifabutinMinor (1)rifabutin decreases levels of estazolam by increasing metabolism. Minor/Significance Unknown.risperidoneMonitor Closely (1)estazolam and risperidone both increase sedation. Use Caution/Monitor.sageMinor (1)estazolam and sage both increase sedation. Minor/Significance Unknown.salmeterolMonitor Closely (1)estazolam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapMonitor Closely (1)estazolam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalMonitor Closely (1)secobarbital and estazolam both increase sedation. Use Caution/Monitor.selinexorSerious - Use Alternative (1)selinexor, estazolam. unspecified interaction mechanism. Avoid or Use Alternate