AdultPediatricDosage Forms & Strengths tablet, extended release 5mEq 10mEq 15mEq Alkalinizing Agent Mild to Moderate Hypocitraturia Urinary citrate >150 mg/day Immediate release: 10 mEq 3 times daily; not to exceed 100 mEq/day Extended release: 15 mEq 2 times daily or 10 mEq 3 times dialy; not to exceed 100 mEq/day Severe Hypocitraturia Urinary citrate <150 mg/day Immediate release: 20 mEq 3 times daily or 15 mEq 4 times daily; not to exceed 100 mEq/day Extended release: 30 mEq 2 times daily or 20 mEq 3 times daily; not to exceed 100 mEq/day Maintenance Titrate dose to achieve urinary citrate 320-640 mg/day & urinary pH 6.0-7.0 (maximum dose 100 mEq/day) Dosing considerations Administer dose with meals or within 30 minutes after meals or bedtime snack) Twenty-four-hour urinary citrate and/or urinary pH measurements should be used to determine adequacy of initial dosage and to evaluate the effectiveness of any dosage changeSafety and efficacy not establishedInteraction CheckerEnter a drug name and potassium citrateNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (7)dextroamphetamine transdermalpotassium citrate will increase the level or effect of dextroamphetamine transdermal by Other (see comment). Avoid or Use Alternate Drug. Urinary alkalinizing agents can increase blood levels and potentiate the action of amphetamine.drospirenonedrospirenone and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.potassium acid phosphatepotassium acid phosphate and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.potassium chloridepotassium chloride and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.potassium phosphates, IVpotassium citrate and potassium phosphates, IV both increase serum potassium. Avoid or Use Alternate Drug.spironolactonespironolactone and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.triamterenetriamterene and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.Monitor Closely (102)acebutololacebutolol and potassium citrate both increase serum potassium. Use Caution/Monitor.amantadinepotassium citrate will increase the level or effect of amantadine by Other (see comment). Modify Therapy/Monitor Closely. Urine pH changes towards alkalinic conditions may lead to an accumulation of amantadine with a possible increase in adverse reactions. Monitor for adverse reactions of amantadine.amilorideamiloride and potassium citrate both increase serum potassium. Use Caution/Monitor.arformoterolpotassium citrate increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.aspirinaspirin and potassium citrate both increase serum potassium. Use Caution/Monitor.aspirin rectalaspirin rectal and potassium citrate both increase serum potassium. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate and potassium citrate both increase serum potassium. Use Caution/Monitor.atenololatenolol and potassium citrate both increase serum potassium. Use Caution/Monitor.benazeprilbenazepril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.potassium citrate and benazepril both increase serum potassium. Use Caution/Monitor. Potassium salts may increase the hyperkalemic effects of ACE inhibitors; the effect may be the result of aldosterone suppression in patients receiving ACE inhibitorsbetaxololbetaxolol and potassium citrate both increase serum potassium. Use Caution/Monitor.bisacodylbisacodyl decreases levels of potassium citrate by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.bisoprololbisoprolol and potassium citrate both increase serum potassium. Use Caution/Monitor.bumetanidepotassium citrate increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.canagliflozinpotassium citrate and canagliflozin both increase serum potassium. Use Caution/Monitor.candesartancandesartan and potassium citrate both increase serum potassium. Use Caution/Monitor.captoprilcaptopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.carvedilolcarvedilol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.celecoxibcelecoxib and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.chlorothiazidepotassium citrate increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.chlorthalidonepotassium citrate increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.choline magnesium trisalicylatecholine magnesium trisalicylate and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.cyclopenthiazidepotassium citrate increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.cyclosporinecyclosporine and potassium citrate both increase serum potassium. Use Caution/Monitor.diclofenacdiclofenac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.diflunisaldiflunisal and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.disopyramidepotassium citrate increases effects of disopyramide by pharmacodynamic synergism. Use Caution/Monitor. Additive cardiovascular depression.dobutaminepotassium citrate increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.enalaprilenalapril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.ephedrinepotassium citrate increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.epinephrinepotassium citrate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.epinephrine racemicpotassium citrate increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.eplerenonepotassium citrate and eplerenone both increase serum potassium. Modify Therapy/Monitor Closely.eprosartaneprosartan and potassium citrate both increase serum potassium. Use Caution/Monitor.esmololesmolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.ethacrynic acidpotassium citrate increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.etodolacetodolac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.fenoprofenfenoprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.finerenonepotassium citrate and finerenone both increase serum potassium. Modify Therapy/Monitor Closely. Finerenone dose adjustment based on current serum potassium concentration. Monitor serum potassium and adjust finerenone dose as described in the prescribing information as necessary.flurbiprofenflurbiprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.formoterolpotassium citrate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.fosinoprilfosinopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.furosemidepotassium citrate increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.gentamicinpotassium citrate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.hydrochlorothiazidepotassium citrate increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.ibuprofenibuprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.ibuprofen IVibuprofen IV and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.indapamidepotassium citrate increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.indomethacinindomethacin and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.irbesartanirbesartan and potassium citrate both increase serum potassium. Use Caution/Monitor.isoproterenolpotassium citrate increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.ketoprofenketoprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.ketorolacketorolac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.labetalollabetalol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.levalbuterolpotassium citrate increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.lisinoprillisinopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.losartanlosartan and potassium citrate both increase serum potassium. Use Caution/Monitor.meclofenamatemeclofenamate and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.mefenamic acidmefenamic acid and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.meloxicammeloxicam and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.metaproterenolpotassium citrate increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.methyclothiazidepotassium citrate increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. .metolazonepotassium citrate increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.metoprololmetoprolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.moexiprilmoexipril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.nabumetonenabumetone and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.nadololnadolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.naproxennaproxen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.nebivololnebivolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.noni juicepotassium citrate and noni juice both increase serum potassium. Use Caution/Monitor.norepinephrinepotassium citrate increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.olmesartanolmesartan and potassium citrate both increase serum potassium. Use Caution/Monitor.oxaprozinoxaprozin and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.penbutololpenbutolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.perindoprilperindopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.pindololpindolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.pirbuterolpotassium citrate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.piroxicampiroxicam and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.potassium citrate/citric acidpotassium citrate and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.potassium iodidepotassium iodide and potassium citrate both increase serum potassium. Use Caution/Monitor.propranololpropranolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.quinaprilquinapril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.ramiprilramipril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.sacubitril/valsartansacubitril/valsartan and potassium citrate both increase serum potassium. Use Caution/Monitor.salicylates (non-asa)salicylates (non-asa) and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.salmeterolpotassium citrate increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.salsalatesalsalate and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.sotalolsotalol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.sparsentansparsentan and potassium citrate both increase serotonin levels. Use Caution/Monitor. Monitor serum potassium frequently.succinylcholinepotassium citrate and succinylcholine both increase serum potassium. Modify Therapy/Monitor Closely.sulfasalazinesulfasalazine and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.sulindacsulindac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.tacrolimustacrolimus and potassium citrate both increase serum potassium. Use Caution/Monitor.telmisartantelmisartan and potassium citrate both increase serum potassium. Use Caution/Monitor.terbutalinepotassium citrate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.timololtimolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.tolmetintolmetin and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.tolvaptanpotassium citrate and tolvaptan both increase serum potassium. Modify Therapy/Monitor Closely.torsemidepotassium citrate increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.trandolapriltrandolapril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.trimethoprimtrimethoprim and potassium citrate both increase serum potassium. Use Caution/Monitor. Trimethoprim decreases urinary potassium excretion. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia.valsartanvalsartan and potassium citrate both increase serum potassium. Use Caution/Monitor.voclosporinvoclosporin and potassium citrate both increase serum potassium. Use Caution/Monitor.Minor (26)acarbosepotassium citrate increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.amphotericin B deoxycholateamphotericin B deoxycholate decreases levels of potassium citrate by increasing renal clearance. Minor/Significance Unknown.cadexomer iodinecadexomer iodine increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.chlorpropamidepotassium citrate increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.glimepiridepotassium citrate increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.glipizidepotassium citrate increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.glyburidepotassium citrate increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin aspartpotassium citrate increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin detemirpotassium citrate increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin glarginepotassium citrate increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin glulisinepotassium citrate increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin lispropotassium citrate increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin NPHpotassium citrate increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.insulin regular humanpotassium citrate increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.iodinated glyceroliodinated glycerol increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.iodineiodine increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.metforminpotassium citrate increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.miglitolpotassium citrate increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.nateglinidepotassium citrate increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.pioglitazonepotassium citrate increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.repaglinidepotassium citrate increases effects of repaglinide by