AdultPediatricGeriatricDosage Forms & Strengths tablet, extended release 300mg 450mg tablet 300mg capsule 150mg 300mg 600mg solution 8mEq/5mL Bipolar Disorder Immediate release: 900-1800 mg/day PO divided q6-8hr Extended release: 900-1800 mg/day PO divided q12hr Lower initial dosage may be used to minimize adverse drug reactions Serum lithium should be monitored 12 hours after dose, twice weekly until serum concentration and clinical condition stabilize, and every other month thereafter Increase dose as tolerated to target serum lithium concentrations of 0.8-1.2 mEq/L (acute goal) or 0.8-1.0 mEq/L (maintenance goal) Huntington's Disease (Orphan) Lithium citrate tetrahydrate (in reverse micelle formulation) Orphan indication sponsor Medesis Pharma; L'Oree des Mas, 34 670 Baillargues, France Administration Preferably taken with foodDosage Forms & Strengths tablet, extended release 300mg 450mg tablet 300mg capsule 150mg 300mg 600mg solution 8mEq/5mL Bipolar Disorder (Off-label) <7 years: Safety and efficacy not established ≥7 years (<30 kg): 300 mg PO BID; increase dose by 300 mg/day at weekly intervals based on response and tolerability; titrate dose to maintain serum trough concentration of 0.8-1.2 mEq/L ≥7 years (<30 kg): 300 mg PO TID; first week of therapy; may increase dose by 300 mg/day at weekly intervals; titrate to response to maintain serum trough concentration of 0.8-1.2 mEq/L Extended release (≥12 years) Fixed dosing <22 kg: 600 mg/day PO divided BID 22-41 kg 900 mg/day PO divided BID >41 kg: 1200 mg/day PO divided BID Increase dose as tolerated to target serum lithium concentrations of 0.8-1.2 mEq/L (acute goal) or 0.8-1.0 mEq/L (maintenance goal) Weight based dosing 15 mg/kg/dose PO PID; not to exceed 600 mg/dose initially Increase dose as tolerated to target serum lithium concentrations of 0.8-1.2 mEq/L (acute goal) or 0.8-1.0 mEq/L (maintenance goal) Dosing in elderly patients should be cautious, usually starting at low end of range Elderly patients often respond to reduced dosage and may exhibit signs of toxicity at serum concentrations ordinarily tolerated by younger patientsInteraction CheckerEnter a drug name and lithiumNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (2)dronedaronelithium and dronedarone both increase QTc interval. Contraindicated.thioridazinelithium and thioridazine both increase QTc interval. Contraindicated.Serious - Use Alternative (112)amiodaronelithium and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulprideamisulpride and lithium both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.lithium and amisulpride both increase QTc interval. Avoid or Use Alternate Drug.anagrelidelithium and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.arsenic trioxidelithium and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and lithium both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineartemether/lumefantrine and lithium both increase QTc interval. Avoid or Use Alternate Drug.asenapinelithium and asenapine both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and lithium both increase QTc interval. Avoid or Use Alternate Drug.azilsartanazilsartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.azithromycinlithium and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.bedaquilinebedaquiline and lithium both increase QTc interval. Avoid or Use Alternate Drug.bremelanotidebremelanotide will decrease the level or effect of lithium by Other (see comment). Avoid or Use Alternate Drug. Bremelanotide may slow gastric emptying and potentially reduces the rate and extent of absorption of concomitantly administered oral medications. Avoid use when taking any oral drug that is dependent on threshold concentrations for efficacy. Interactions listed are representative examples and do not include all possible clinical examples.buprenorphinelithium and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and lithium both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and lithium both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalbuprenorphine transdermal and lithium both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and lithium both increase QTc interval. Avoid or Use Alternate Drug.candesartancandesartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.ceritinibceritinib and lithium both increase QTc interval. Avoid or Use Alternate Drug.chloroquinechloroquine and lithium both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazinelithium and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and lithium both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinclarithromycin and lithium both increase QTc interval. Avoid or Use Alternate Drug.clozapineclozapine and lithium both increase QTc interval. Avoid or Use Alternate Drug.crizotinibcrizotinib and lithium both increase QTc interval. Avoid or Use Alternate Drug.desfluranedesflurane and lithium both increase QTc interval. Avoid or Use Alternate Drug.desvenlafaxinelithium and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.disopyramidelithium and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.dofetilidelithium and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.donepezildonepezil and lithium both increase QTc interval. Avoid or Use Alternate Drug.droperidollithium and droperidol both increase QTc interval. Avoid or Use Alternate Drug.eliglustatlithium and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.encorafenibencorafenib and lithium both increase QTc interval. Avoid or Use Alternate Drug.entrectinibentrectinib and lithium both increase QTc interval. Avoid or Use Alternate Drug.eprosartaneprosartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.eribulineribulin and lithium both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baselithium and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatelithium and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatelithium and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatelithium and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.fexinidazolefexinidazole and lithium both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.flecainidelithium and flecainide both increase QTc interval. Avoid or Use Alternate Drug.foscarnetlithium and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.glasdegiblithium and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.goserelinlithium and goserelin both increase QTc interval. Avoid or Use Alternate Drug.hydroxychloroquine sulfatelithium and hydroxychloroquine sulfate both increase QTc interval. Avoid or Use Alternate Drug.ibutilidelithium and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.iloperidonelithium and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.inotuzumablithium and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.irbesartanirbesartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.isocarboxazidisocarboxazid and lithium both increase serotonin levels. Avoid or Use Alternate Drug.isofluraneisoflurane and lithium both increase QTc interval. Avoid or Use Alternate Drug.ivosideniblithium and ivosidenib both decrease QTc interval. Avoid or Use Alternate Drug.lefamulinlefamulin and lithium both increase QTc interval. Avoid or Use Alternate Drug.lenvatiniblithium and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.linezolidlinezolid and lithium both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.lopinavirlithium and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.lorcaserinlithium and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.losartanlosartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.macimorelinlithium and macimorelin both increase QTc interval. Avoid or Use Alternate Drug.maprotilinelithium and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.mefloquinemefloquine increases toxicity of lithium by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.methadonelithium and methadone both increase QTc interval. Avoid or Use Alternate Drug.metoclopramide intranasallithium, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midostaurinlithium and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.mifepristonelithium and mifepristone both increase QTc interval. Avoid or Use Alternate Drug.mirtazapinelithium and mirtazapine both increase QTc interval. Avoid or Use Alternate Drug.mobocertiniblithium and mobocertinib both increase QTc interval. Avoid or Use Alternate Drug.moxifloxacinlithium and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotiniblithium and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.olmesartanolmesartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.olopatadine intranasallithium and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. ondansetronlithium and ondansetron both increase QTc interval. Avoid or Use Alternate Drug.osimertiniblithium and osimertinib both increase QTc interval. Avoid or Use Alternate Drug.oxaliplatinlithium and oxaliplatin both increase QTc interval. Avoid or Use Alternate Drug.ozanimodozanimod increases toxicity of lithium by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.lithium and ozanimod both increase QTc interval. Avoid or Use Alternate Drug.paliperidonelithium and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.panobinostatlithium and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.pazopaniblithium and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.pentamidinelithium and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.phenelzinephenelzine and lithium both increase serotonin levels. Avoid or Use Alternate Drug.pimavanserinlithium and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.pimozidelithium and pimozide both increase QTc interval. Contraindicated.pitolisantlithium and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.ponesimodlithium and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.procainamidelithium and procainamide both increase QTc interval. Avoid or Use Alternate Drug.procarbazineprocarbazine and lithium both increase serotonin levels. Avoid or Use Alternate Drug.propafenonelithium and propafenone both increase QTc interval. Avoid or Use Alternate Drug.quetiapinelithium and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.quinidinelithium and quinidine both increase QTc interval. Avoid or Use Alternate Drug.quininelithium and quinine both increase QTc interval. Avoid or Use Alternate Drug.ribocicliblithium and ribociclib both increase QTc interval. Avoid or Use Alternate Drug.ropeginterferon alfa 2bropeginterferon alfa 2b and lithium both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.sacubitril/valsartansacubitril/valsartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.sacubitril/valsartan increases levels of lithium by unknown mechanism. Avoid or Use Alternate Drug.saquinavirlithium and saquinavir both increase QTc interval. Avoid or Use Alternate Drug.selpercatiniblithium and selpercatinib both increase QTc interval. Avoid or Use Alternate Drug.sevofluranesevoflurane and lithium both increase QTc interval. Avoid or Use Alternate Drug.siponimodlithium and siponimod both increase QTc interval. Avoid or Use Alternate Drug.sodium phosphate rectalsodium phosphate rectal decreases levels of lithium by Other (see comment). Avoid or Use Alternate Drug. Comment: Sodium phosphates may cause hypernatremia which increases lithium renal clearance; more common with large doses of oral sodium phosphate.sorafeniblithium and sorafenib both increase QTc interval. Avoid or Use Alternate Drug.sotalollithium and sotalol both increase QTc interval. Avoid or Use Alternate Drug.telmisartantelmisartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.tetrabenazinelithium and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.toremifenelithium and toremifene both increase QTc interval. Avoid or Use Alternate Drug.tranylcyprominetranylcypromine and lithium both increase serotonin levels. Avoid or Use Alternate Drug.trazodonelithium and trazodone both increase QTc interval. Avoid or Use Alternate Drug.valsartanvalsartan increases toxicity of lithium by decreasing renal clearance. Avoid or Use Alternate Drug.vandetaniblithium and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.vemurafeniblithium and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.vilazodonelithium, vilazodone. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. .vortioxetinelithium, vortioxetine. Either increases effects of the other by serotonin levels. Avoid or Use Alternate Drug.ziprasidonelithium and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (220)5-HTP5-HTP and lithium both increase serotonin levels. Use Caution/Monitor.aceclofenacaceclofenac increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.acemetacinacemetacin increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.albuterolalbuterol and lithium both increase QTc interval. Use Caution/Monitor.alfuzosinalfuzosin and lithium both increase QTc interval. Use Caution/Monitor.almotriptanalmotriptan and lithium both increase serotonin levels. Use Caution/Monitor.amitriptylineamitriptyline and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.lithium and amitriptyline both increase QTc interval. Use Caution/Monitor.amoxapineamoxapine and lithium