neuron.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluramineMonitor Closely (2)epinephrine racemic and dexfenfluramine both decrease sedation. Use Caution/Monitor. epinephrine racemic and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidateMonitor Closely (2)epinephrine racemic and dexmethylphenidate both decrease sedation. Use Caution/Monitor. epinephrine racemic and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetamineMonitor Closely (2)epinephrine racemic and dextroamphetamine both decrease sedation. Use Caution/Monitor. epinephrine racemic and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramideMonitor Closely (1)dextromoramide increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diclofenacMonitor Closely (1)diclofenac increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.diethylpropionMonitor Closely (2)epinephrine racemic and diethylpropion both decrease sedation. Use Caution/Monitor. epinephrine racemic and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diflunisalMonitor Closely (1)diflunisal increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.digoxinMonitor Closely (1)digoxin increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.disopyramideContraindicated (1)epinephrine racemic and disopyramide both increase QTc interval. Contraindicated.dobutamineMonitor Closely (3)dobutamine and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. dobutamine and epinephrine racemic both decrease sedation. Use Caution/Monitor. dobutamine and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dofetilideSerious - Use Alternative (1)epinephrine racemic and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetronMonitor Closely (1)epinephrine racemic and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.dopamineMonitor Closely (2)epinephrine racemic and dopamine both decrease sedation. Use Caution/Monitor. epinephrine racemic and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexamineMonitor Closely (4)dopexamine, epinephrine racemic. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. dopexamine and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. dopexamine and epinephrine racemic both decrease sedation. Use Caution/Monitor. dopexamine and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dosulepinSerious - Use Alternative (1)epinephrine racemic and dosulepin both increase QTc interval. Avoid or Use Alternate Drug.doxepinMonitor Closely (2)doxepin increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor. doxepin increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and doxepin both increase QTc interval. Avoid or Use Alternate Drug. doxepin, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dronedaroneSerious - Use Alternative (1)epinephrine racemic and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolMonitor Closely (1)droperidol increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine racemic and droperidol both increase QTc interval. Avoid or Use Alternate Drug.drospirenoneMonitor Closely (1)drospirenone increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.entacaponeMonitor Closely (1)entacapone will increase the level or effect of epinephrine racemic by decreasing metabolism. Use Caution/Monitor. Entacapone is a COMT inhibitor. Caution if coadministered with drugs metabolized by COMT. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure.ephedrineMonitor Closely (3)ephedrine and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. ephedrine and epinephrine racemic both decrease sedation. Use Caution/Monitor. ephedrine and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrineMonitor Closely (4)epinephrine, epinephrine racemic. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. epinephrine and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. epinephrine and epinephrine racemic both decrease sedation. Use Caution/Monitor. epinephrine and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.erythromycin baseSerious - Use Alternative (1)epinephrine racemic and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)epinephrine racemic and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)epinephrine racemic and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)epinephrine racemic and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.esmololMonitor Closely (2)esmolol decreases effects of epinephrine racemic by pharmacodynamic antagonism. Use Caution/Monitor. esmolol increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethacrynic acidMonitor Closely (1)epinephrine racemic and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine racemic, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.ethanolMonitor Closely (1)ethanol increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.etodolacMonitor Closely (1)etodolac increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.etomidateSerious - Use Alternative (1)etomidate increases levels of epinephrine racemic by decreasing metabolism. Contraindicated.eucalyptusMinor (1)eucalyptus increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.fenfluramineMonitor Closely (2)epinephrine racemic and fenfluramine both decrease sedation. Use Caution/Monitor. epinephrine racemic and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.fenoprofenMonitor Closely (1)fenoprofen increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.flecainideMonitor Closely (1)epinephrine racemic and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.fluconazoleSerious - Use Alternative (1)epinephrine racemic and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetineMonitor Closely (1)epinephrine racemic and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazineMonitor Closely (2)fluphenazine decreases effects of epinephrine racemic by pharmacodynamic antagonism. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. fluphenazine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine racemic and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.flurazepamMonitor Closely (1)flurazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurbiprofenMonitor Closely (1)flurbiprofen increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluvoxamineMonitor Closely (1)fluvoxamine and epinephrine racemic both increase QTc interval. Modify Therapy/Monitor Closely.formoterolMonitor Closely (3)formoterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. formoterol and epinephrine racemic both decrease sedation. Use Caution/Monitor. formoterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine racemic and formoterol both increase QTc interval. Avoid or Use Alternate Drug.foscarnetMonitor Closely (1)epinephrine racemic and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.furosemideMonitor Closely (1)epinephrine racemic and furosemide both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine racemic, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.gentamicinMonitor Closely (1)epinephrine racemic and gentamicin both decrease serum potassium. Use Caution/Monitor.green teaMonitor Closely (1)green tea increases effects of epinephrine racemic by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.haloperidolMonitor Closely (1)haloperidol increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine racemic and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydrochlorothiazideMonitor Closely (1)epinephrine racemic and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine racemic, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.hydromorphoneMonitor Closely (1)hydromorphone increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofenMonitor Closely (1)ibuprofen increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen IVMonitor Closely (1)ibuprofen IV increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibutilideContraindicated (1)epinephrine racemic and ibutilide both increase QTc interval. Contraindicated.iloperidoneMonitor Closely (2)epinephrine racemic and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely. iloperidone increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.imipramineMonitor Closely (2)imipramine increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor. imipramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and imipramine both increase QTc interval. Avoid or Use Alternate Drug. imipramine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.indapamideContraindicated (1)epinephrine racemic and indapamide both increase QTc interval. Contraindicated.Monitor Closely (1)epinephrine racemic and indapamide both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine racemic, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.indomethacinMonitor Closely (1)indomethacin increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.iobenguane I 123Contraindicated (1)epinephrine racemic decreases levels of iobenguane I 123 by receptor binding competition. Contraindicated. If clinically appropriate, discontinue drugs that compete for NE receptor sites for at least 5 half-lives; may cause false-negative imaging results.isocarboxazidSerious - Use Alternative (1)isocarboxazid increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.isoproterenolMonitor Closely (3)isoproterenol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. isoproterenol and epinephrine racemic both decrease sedation. Use Caution/Monitor. isoproterenol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.ketamineSerious - Use Alternative (1)ketamine increases levels of epinephrine racemic by unknown mechanism. Avoid or Use Alternate Drug.ketoconazoleSerious - Use Alternative (1)epinephrine racemic and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.ketoprofenMonitor Closely (1)ketoprofen increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolacMonitor Closely (1)ketorolac increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolac intranasalMonitor Closely (1)ketorolac intranasal increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .ketotifen, ophthalmicMonitor Closely (1)ketotifen, ophthalmic increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.labetalolMonitor Closely (2)labetalol decreases effects of epinephrine racemic by pharmacodynamic antagonism. Use Caution/Monitor. labetalol increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.levalbuterolMonitor Closely (3)levalbuterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. levalbuterol and epinephrine racemic both decrease sedation. Use Caution/Monitor. levalbuterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.levofloxacinMonitor Closely (1)epinephrine racemic and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levoketoconazoleSerious - Use Alternative (1)epinephrine racemic and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranSerious - Use Alternative (1)levomilnacipran increases levels of epinephrine racemic by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of paroxysmal HTN, arrhythmia.levorphanolMonitor Closely (1)levorphanol increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.linezolidSerious - Use Alternative (1)linezolid increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lisdexamfetamineMonitor Closely (2)epinephrine racemic and lisdexamfetamine both decrease sedation. Use Caution/Monitor. epinephrine racemic and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.lofepramineMonitor Closely (2)lofepramine increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor. lofepramine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and lofepramine both increase QTc interval. Avoid or Use Alternate