AdultPediatricGeriatricDosage Forms & Strengths tablet 50mg 100mg 150mg 300mg tablet, extended-release 150mg 300mg Depression Initial 150 mg/day PO divided q8-12hr Increase by 50 mg/day q3-7Days Outpatient: No more than 400 mg/day Inpatient: No more than 600 mg/day Oleptro (extended-release) 150 mg PO HS initially; may increase by increments of 75 mg/day q3Days; not to exceed 375 mg/day Swallow whole or may break in half along scored line; do not chew or crush Insomnia (Off-label) 50-100 mg PO qDay Aggressive Behavior (Off-label) Initial: 50 mg PO q12hr Maintenance: 75-400 mg/day divided PO q6-12hr Cocaine Withdrawal (Off-label) 150-200 mg PO qDay Alcohol Withdrawal (Off-label) 100-600 mg/day divided PO Prevention of Migraine (Off-label) 100 mg PO qDay Dose considerations MAO inhibitors: Do not administer trazodone within 14 days of administering a MAO inhibitor when treating a psychiatric disorder Coadministration with MAO inhibitors linezolid or IV methylene blue: Trazodone not recommended in patients actively receiving linezolid or IV methylene blue; consider other interventions if treating psychiatric condition; if coadministration necessary, because benefits outweigh risks, monitor for serotonin syndrome for 2 weeks or until 24 hr after last dose of linezolid or IV methylene blue, whichever comes first; may resume trazodone 24 hr after last dose of linezolid or IV methylene blueDosage Forms & Strengths tablet 50mg 100mg 150mg 300mg tablet, extended-release 150mg 300mg Depression (Off-label) <6 years: Safety and efficacy not established 6-12 years: 1.5-2 mg/kg/day PO in divided doses initially; not to exceed 6 mg/kg/day divded q8hr >12 years: 25-50 mg/day PO; increase by 100-150 mg in divided doses See Black Box Warnings Dravet Syndrome (Orphan) Orphan designation for treatment of Dravet syndrome Sponsor Epygenix Therapeutics, Inc; 140 E. Ridgewood Avenue, Suite 415 South Tower; Paramus, New Jersey 07652 Depression Immediate release: 25-50 mgPO qHS; increase dose by 25-50 mg every three days if inpatient or every week if oupatient not to exceed 75-150 mg/day Extended release: Experience limited; use 150 mg PO HS initially; may increase by increments of 75 mg/day q3Days; not to exceed 375 mg/dayInteraction CheckerEnter a drug name and trazodoneNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (17)arsenic trioxidetrazodone and arsenic trioxide both increase QTc interval. Contraindicated.disopyramidetrazodone and disopyramide both increase QTc interval. Contraindicated.eliglustattrazodone increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given concomitantly with strong or moderate CYP3A inhibitors.ibutilidetrazodone and ibutilide both increase QTc interval. Contraindicated.indapamidetrazodone and indapamide both increase QTc interval. Contraindicated.isocarboxazidisocarboxazid and trazodone both increase serotonin levels. Contraindicated.lefamulinlefamulin will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.pentamidinetrazodone and pentamidine both increase QTc interval. Contraindicated.phenelzinephenelzine and trazodone both increase serotonin levels. Contraindicated.pimozidetrazodone and pimozide both increase QTc interval. Contraindicated.procainamidetrazodone and procainamide both increase QTc interval. Contraindicated.procarbazineprocarbazine and trazodone both increase serotonin levels. Contraindicated. Combination is contraindicated within 2 weeks of MAOI use.quinidinequinidine and trazodone both increase QTc interval. Contraindicated.safinamidetrazodone, safinamide. Either increases toxicity of the other by serotonin levels. Contraindicated. Concomitant use could result in life-threatening serotonin syndrome.saquinavirtrazodone will decrease the level or effect of saquinavir by P-glycoprotein (MDR1) efflux transporter. Contraindicated.saquinavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.sotaloltrazodone and sotalol both increase QTc interval. Contraindicated.tranylcyprominetranylcypromine and trazodone both increase serotonin levels. Contraindicated.Serious - Use Alternative (181)abametapirabametapir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.albuteroltrazodone, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amiodaronetrazodone and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.amisulpridetrazodone and amisulpride both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineamitriptyline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.amoxapineamoxapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.anagrelideanagrelide and trazodone both increase QTc interval. Avoid or Use Alternate Drug.apalutamideapalutamide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.apomorphineapomorphine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.arformoteroltrazodone, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.aripiprazolearipiprazole and trazodone both increase QTc interval. Avoid or Use Alternate Drug.artemetherartemether and trazodone both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrinetrazodone and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.asenapineasenapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.asenapine transdermalasenapine transdermal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.atomoxetineatomoxetine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.bedaquilinebedaquiline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.benzphetaminetrazodone, benzphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.bosentanbosentan will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.buprenorphinebuprenorphine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine buccalbuprenorphine buccal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine subdermal implantbuprenorphine subdermal implant and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine transdermalbuprenorphine transdermal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.buprenorphine, long-acting injectionbuprenorphine, long-acting injection and trazodone both increase QTc interval. Avoid or Use Alternate Drug.bupropiontrazodone increases toxicity of bupropion by unspecified interaction mechanism. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible.buspironetrazodone and buspirone both increase serotonin levels. Avoid or Use Alternate Drug.calcium/magnesium/potassium/sodium oxybatestrazodone, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.ceritinibceritinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.ceritinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chloramphenicolchloramphenicol will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.chloroquinechloroquine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazinechlorpromazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.citalopramcitalopram and trazodone both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinclarithromycin will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and clomipramine both increase serotonin levels. Avoid or Use Alternate Drug.clonidinetrazodone decreases effects of clonidine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.clozapineclozapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.cobicistatcobicistat will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.conivaptanconivaptan will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.crizotinibcrizotinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.cyclobenzaprinetrazodone and cyclobenzaprine both increase serotonin levels. Avoid or Use Alternate Drug.degarelixdegarelix and trazodone both increase QTc interval. Avoid or Use Alternate Drug.desfluranedesflurane and trazodone both increase QTc interval. Avoid or Use Alternate Drug.desipraminedesipramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.desvenlafaxinetrazodone and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.dexfenfluraminetrazodone, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexmethylphenidatetrazodone, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextroamphetaminetrazodone, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextromethorphantrazodone and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.diethylpropiontrazodone, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dobutaminetrazodone, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilidetrazodone and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.donepezildonepezil and trazodone both increase QTc interval. Avoid or Use Alternate Drug.dopaminetrazodone, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexaminetrazodone, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dosulepintrazodone and dosulepin both increase serotonin levels. Avoid or Use Alternate Drug.doxepindoxepin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.dronedaronetrazodone and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidoltrazodone and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineduloxetine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.efavirenzefavirenz and trazodone both increase QTc interval. Avoid or Use Alternate Drug.eliglustateliglustat and trazodone both increase QTc interval. Avoid or Use Alternate Drug.encorafenibencorafenib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.entrectinibtrazodone and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.ephedrinetrazodone, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineepinephrine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine racemicepinephrine racemic and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.eribulineribulin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.erythromycin basetrazodone and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinatetrazodone and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionatetrazodone and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearatetrazodone and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramescitalopram and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.etravirineetravirine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.fenfluraminetrazodone, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic