AdultPediatricGeriatricDosage Forms & Strengths tablet 20mg capsule, extended release 60mg Overactive Bladder Immediate release: 20 mg PO twice daily Extended Release: 60 mg PO qDay Renal Impairment CrCl <30 mL/min: 20 mg immediate release PO qHS; extended-release not recommended CrCl≥30 mL/min: Dose adjustment not provided by manufacturer; monitor for increased adverse effects Hepatic Impairment Use with caution; dose adjustment not provided by manufacturerSafety and efficacy not established>75 years Immediate release: May titrate down to 20 mg immediated release qDay based on tolerability Extended release: 60 mg PO qDayInteraction CheckerEnter a drug name and trospium chlorideNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (4)glycopyrronium tosylate topicalglycopyrronium tosylate topical, trospium chloride. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.pramlintidepramlintide, trospium chloride. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.revefenacinrevefenacin and trospium chloride both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.secretintrospium chloride decreases effects of secretin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Concomitant use of anticholinergic drugs may cause a hyporesponse to stimulation testing with secretin. Discontinue anticholinergic drugs at least 5 half-lives before administering secretin.Monitor Closely (101)abobotulinumtoxinAabobotulinumtoxinA increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .aclidiniumaclidinium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.amantadinetrospium chloride, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amitriptylinetrospium chloride and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapinetrospium chloride and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.aripiprazoletrospium chloride decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.aripiprazole increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atracuriumatracurium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.atropineatropine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.atropine IV/IMatropine IV/IM and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna alkaloidsbelladonna alkaloids and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opiumbelladonna and opium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.benperidoltrospium chloride decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.benperidol increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benztropinebenztropine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. bethanecholbethanechol increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbacholcarbachol increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.cevimelinecevimeline increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazinetrospium chloride decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.chlorpromazine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cisatracuriumcisatracurium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.clomipraminetrospium chloride and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.clozapinetrospium chloride decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.clozapine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cyclizinecyclizine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.darifenacindarifenacin and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.desipraminetrospium chloride and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.dicyclominedicyclomine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.digoxindigoxin, trospium chloride. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.diphenhydraminediphenhydramine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.donepezildonepezil increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.donepezil transdermaldonepezil transdermal, trospium chloride. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.dosulepintrospium chloride and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepintrospium chloride and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.droperidoltrospium chloride decreases levels of droperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.droperidol increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.echothiophate iodideechothiophate iodide increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.fesoterodinefesoterodine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.flavoxateflavoxate and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.fluphenazinetrospium chloride decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.galantaminegalantamine increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.glycopyrrolateglycopyrrolate and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrrolate inhaledglycopyrrolate inhaled and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.haloperidoltrospium chloride decreases levels of haloperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.haloperidol increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.henbanehenbane and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.homatropinehomatropine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine Ahuperzine A increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hyoscyaminehyoscyamine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.hyoscyamine sprayhyoscyamine spray and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.iloperidonetrospium chloride decreases levels of iloperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor.iloperidone increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.imipraminetrospium chloride and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.ipratropiumipratropium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.lofepraminetrospium chloride and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.loxapinetrospium chloride decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor.loxapine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.loxapine inhaledloxapine inhaled increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.trospium chloride decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor.maprotilinetrospium chloride and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.meclizinemeclizine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.metforminmetformin will decrease the level or effect of trospium chloride by increasing renal clearance. Use Caution/Monitor. Coadministration reduced steady state trospium systemic exposure (decreased AUC and Cmax) by competing for renal tubular secretionmethscopolaminemethscopolamine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.morphinemorphine, trospium chloride. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.neostigmineneostigmine increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinetrospium chloride and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.olanzapinetrospium chloride decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.olanzapine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.oliceridinetrospium chloride increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.onabotulinumtoxinAonabotulinumtoxinA and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrinetrospium chloride and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutyninoxybutynin and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin topicaloxybutynin topical and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin transdermaloxybutynin transdermal and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.paliperidonetrospium chloride decreases levels of paliperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.paliperidone increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pancuroniumpancuronium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.pancuronium, trospium chloride. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.perphenazinetrospium chloride decreases levels of perphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.perphenazine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.physostigminephysostigmine increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pilocarpinepilocarpine increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozidetrospium chloride decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.prabotulinumtoxinAtrospium chloride, prabotulinumtoxinA. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects.pralidoximepralidoxime and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.procainamideprocainamide, trospium chloride. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.prochlorperazinetrospium chloride decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.promethazinetrospium chloride decreases levels of promethazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.promethazine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.propanthelinepropantheline and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.protriptylinetrospium chloride and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.pyridostigminepyridostigmine increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.quetiapinetrospium chloride decreases levels of quetiapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.quetiapine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.rapacuroniumrapacuronium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.risperidonetrospium chloride decreases levels of risperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of risperidone by pharmacodynamic antagonism. Use Caution/Monitor.risperidone increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.rivastigminetrospium chloride decreases effects of rivastigmine by cholinergic effects/transmission. Use Caution/Monitor.rocuroniumrocuronium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.scopolaminescopolamine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.solifenacinsolifenacin and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.succinylcholinesuccinylcholine increases and trospium chloride decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.tenofovir DFtenofovir DF, trospium chloride. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.thioridazinetrospium chloride decreases levels of thioridazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of thioridazine by pharmacodynamic antagonism. Use Caution/Monitor.thioridazine increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.thiothixenetrospium chloride decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.trospium chloride decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.thiothixene increases effects of trospium chloride by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.tiotropiumtiotropium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.tolterodinetolterodine and trospium chloride both decrease