use caution. Use Caution/Monitor.meperidinemeperidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamine and meperidine both increase serotonin levels. Modify Therapy/Monitor Closely.meprobamatemeprobamate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaproterenolmetaproterenol and dextroamphetamine both decrease sedation. Use Caution/Monitor.metaproterenol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methadonemethadone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methamphetaminedextroamphetamine and methamphetamine both decrease sedation. Use Caution/Monitor.dextroamphetamine and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methyldopamethyldopa increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.methylenedioxymethamphetaminedextroamphetamine and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.dextroamphetamine and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methylphenidatedextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.midazolammidazolam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midodrinedextroamphetamine and midodrine both decrease sedation. Use Caution/Monitor.dextroamphetamine and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.milnacipranmilnacipran and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.mirtazapinemirtazapine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamine and mirtazapine both increase serotonin levels. Use Caution/Monitor.modafinildextroamphetamine and modafinil both decrease sedation. Use Caution/Monitor.morphinemorphine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamine and morphine both increase serotonin levels. Use Caution/Monitor.motherwortmotherwort increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.moxonidinemoxonidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabilonenabilone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nalbuphinenalbuphine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.naratriptannaratriptan and dextroamphetamine both increase serotonin levels. Use Caution/Monitor.nefazodonenefazodone and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.norepinephrinenorepinephrine and dextroamphetamine both decrease sedation. Use Caution/Monitor.norepinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.nortriptylinenortriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptyline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.nortriptyline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.olanzapineolanzapine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.omeprazoleomeprazole, dextroamphetamine. Other (see comment). Use Caution/Monitor. Comment: Reduced gastric acidity caused by proton pump inhibitors decreases time to Tmax for amphetamine and dextroamphetamine. AUC was unaffected. .opium tinctureopium tincture increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxazepamoxazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxycodoneoxycodone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxymorphoneoxymorphone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxytocinoxytocin increases effects of dextroamphetamine by pharmacodynamic synergism. Use Caution/Monitor.paliperidonepaliperidone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pantoprazolepantoprazole, dextroamphetamine. Other (see comment). Use Caution/Monitor. Comment: Reduced gastric acidity caused by proton pump inhibitors decreases time to Tmax for amphetamine and dextroamphetamine. AUC was unaffected. .papaveretumpapaveretum increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.paroxetineparoxetine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.paroxetine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.pentazocinepentazocine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamine and pentazocine both increase serotonin levels. Use Caution/Monitor.pentobarbitalpentobarbital increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.perphenazineperphenazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.perphenazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.phendimetrazinedextroamphetamine and phendimetrazine both decrease sedation. Use Caution/Monitor.dextroamphetamine and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenobarbitalphenobarbital increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenterminedextroamphetamine and phentermine both decrease sedation. Use Caution/Monitor.dextroamphetamine and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrinedextroamphetamine and phenylephrine both decrease sedation. Use Caution/Monitor.dextroamphetamine and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrine POdextroamphetamine and phenylephrine PO both decrease sedation. Use Caution/Monitor.dextroamphetamine and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.pholcodinepholcodine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozidepimozide increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pirbuterolpirbuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.pirbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.primidoneprimidone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazineprochlorperazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.promazinepromazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.promethazinepromethazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.promethazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.propylhexedrinedextroamphetamine and propylhexedrine both decrease sedation. Use Caution/Monitor.dextroamphetamine and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.protriptylineprotriptyline increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptyline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.protriptyline increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.pseudoephedrinedextroamphetamine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.quazepamquazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.quetiapinequetiapine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.quinidinequinidine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.rabeprazolerabeprazole, dextroamphetamine. Other (see comment). Use Caution/Monitor. Comment: Reduced gastric acidity caused by proton pump inhibitors decreases time to Tmax for amphetamine and dextroamphetamine. AUC was unaffected. .risperidonerisperidone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.rizatriptanrizatriptan and dextroamphetamine both increase serotonin levels. Use Caution/Monitor.salmeterolsalmeterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.salmeterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.SAMedextroamphetamine and SAMe both increase serotonin levels. Use Caution/Monitor.scullcapscullcap increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.secobarbitalsecobarbital increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.selegiline transdermalselegiline transdermal and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.serdexmethylphenidate/dexmethylphenidateserdexmethylphenidate/dexmethylphenidate and dextroamphetamine both decrease sedation. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.sertralinesertraline will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.sertraline and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.shepherd's purseshepherd's purse increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.sodium acid phosphatesodium acid phosphate decreases levels of dextroamphetamine by increasing renal clearance. Use Caution/Monitor.sodium bicarbonatesodium bicarbonate will increase the level or effect of dextroamphetamine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.sodium citrate/citric acidsodium citrate/citric acid will increase the level or effect of dextroamphetamine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.sodium lactatesodium lactate will increase the level or effect of dextroamphetamine by passive renal tubular reabsorption - basic urine. Use Caution/Monitor.sodium zirconium cyclosilicatesodium zirconium cyclosilicate will increase the level or effect of amphetamine by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Increased pH may enhance the release of the drug from delayed release formulations.sodium zirconium cyclosilicate will increase the level or effect of dextroamphetamine by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Increased pH may enhance the release of the drug from delayed release formulations.solriamfetoldextroamphetamine and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.sufentanil SLsufentanil SL, amphetamine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.Minor (56)acetazolamideacetazolamide increases levels of dextroamphetamine by passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown.alfentanildextroamphetamine increases effects of alfentanil by unspecified interaction mechanism. Minor/Significance Unknown.amantadineamantadine, dextroamphetamine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Potential for additive CNS stimulation.American ginsengAmerican ginseng increases effects of dextroamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.amiodaroneamiodarone will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.asenapineasenapine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.ashwagandhaashwagandha increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown.belladonna and opiumdextroamphetamine increases effects of belladonna and opium by unspecified interaction mechanism. Minor/Significance Unknown.buprenorphinedextroamphetamine increases effects of buprenorphine by unspecified interaction mechanism. Minor/Significance Unknown.buprenorphine buccaldextroamphetamine increases effects of buprenorphine buccal by unspecified interaction mechanism. Minor/Significance Unknown.butorphanoldextroamphetamine increases effects of butorphanol by unspecified interaction mechanism. Minor/Significance Unknown.celandinecelandine increases effects of dextroamphetamine by unspecified interaction mechanism. Minor/Significance Unknown. Based on animal studies.celecoxibcelecoxib will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.chloroquinechloroquine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.cimetidinecimetidine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.codeinedextroamphetamine increases effects of codeine by unspecified interaction mechanism. Minor/Significance Unknown.darifenacindarifenacin will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.desmopressindesmopressin increases effects of dextroamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.dextromoramidedextroamphetamine increases effects of dextromoramide by unspecified interaction mechanism. Minor/Significance Unknown.diamorphinedextroamphetamine increases effects of diamorphine by unspecified interaction mechanism. Minor/Significance Unknown.difenoxin hcldextroamphetamine increases effects of difenoxin hcl by unspecified interaction mechanism. Minor/Significance Unknown.diphenhydraminediphenhydramine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.diphenoxylate hcldextroamphetamine increases effects of diphenoxylate hcl by unspecified interaction mechanism. Minor/Significance Unknown.dipipanonedextroamphetamine increases effects of dipipanone by unspecified interaction mechanism. Minor/Significance Unknown.dronedaronedronedarone will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.ethosuximidedextroamphetamine decreases levels of ethosuximide by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.eucalyptuseucalyptus increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.guaranaguarana increases effects of dextroamphetamine by pharmacodynamic synergism. Minor/Significance Unknown.haloperidolhaloperidol will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.hydromorphonedextroamphetamine increases effects of hydromorphone by unspecified interaction mechanism. Minor/Significance Unknown.imatinibimatinib will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.levorphanoldextroamphetamine increases effects of levorphanol by unspecified interaction mechanism. Minor/Significance Unknown.maravirocmaraviroc will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.marijuanamarijuana will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.meperidinedextroamphetamine increases effects of meperidine by unspecified interaction mechanism. Minor/Significance Unknown.methadonedextroamphetamine increases effects of methadone by unspecified interaction mechanism. Minor/Significance Unknown.morphinedextroamphetamine increases effects of morphine by unspecified interaction mechanism. Minor/Significance Unknown.nalbuphinedextroamphetamine increases effects of nalbuphine by unspecified interaction mechanism. Minor/Significance Unknown.opium tincturedextroamphetamine increases effects of opium tincture by unspecified interaction mechanism. Minor/Significance Unknown.oxycodonedextroamphetamine increases effects of oxycodone by unspecified interaction mechanism. Minor/Significance Unknown.oxymorphonedextroamphetamine increases effects of oxymorphone by unspecified interaction mechanism. Minor/Significance Unknown.papaveretumdextroamphetamine