Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)epinephrine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)epinephrine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)epinephrine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.esmololMonitor Closely (2)esmolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. esmolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethacrynic acidMonitor Closely (1)epinephrine and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.ethanolMonitor Closely (1)ethanol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.etherSerious - Use Alternative (1)ether increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.etodolacMonitor Closely (1)etodolac increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.etomidateSerious - Use Alternative (1)etomidate increases levels of epinephrine by decreasing metabolism. Contraindicated.eucalyptusMinor (1)eucalyptus increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.fenfluramineMonitor Closely (2)epinephrine and fenfluramine both decrease sedation. Use Caution/Monitor. epinephrine and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.fenoprofenMonitor Closely (1)fenoprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.flecainideMonitor Closely (1)epinephrine and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.fluconazoleSerious - Use Alternative (1)epinephrine and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetineMonitor Closely (1)epinephrine and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazineMonitor Closely (3)fluphenazine, epinephrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. fluphenazine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. fluphenazine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.flurazepamMonitor Closely (1)flurazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurbiprofenMonitor Closely (1)flurbiprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluvoxamineMonitor Closely (1)fluvoxamine and epinephrine both increase QTc interval. Modify Therapy/Monitor Closely.formoterolMonitor Closely (3)epinephrine and formoterol both decrease serum potassium. Use Caution/Monitor. epinephrine and formoterol both decrease sedation. Use Caution/Monitor. epinephrine and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.foscarnetMonitor Closely (1)epinephrine and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.furosemideMonitor Closely (1)epinephrine and furosemide both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.gentamicinMonitor Closely (1)epinephrine and gentamicin both decrease serum potassium. Use Caution/Monitor.green teaMonitor Closely (1)green tea increases effects of epinephrine by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.haloperidolMonitor Closely (1)haloperidol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydralazineMonitor Closely (1)hydralazine, epinephrine. Mechanism: pharmacodynamic antagonism. Use Caution/Monitor. Sympathomimetics can antagonize the activity of some antihypertensive agents.hydrochlorothiazideMonitor Closely (1)epinephrine and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.hydromorphoneMonitor Closely (1)hydromorphone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofenMonitor Closely (1)ibuprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen IVMonitor Closely (1)ibuprofen IV increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibutilideContraindicated (1)epinephrine and ibutilide both increase QTc interval. Contraindicated.iloperidoneMonitor Closely (2)epinephrine and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely. iloperidone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.imipramineMonitor Closely (2)imipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. imipramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and imipramine both increase QTc interval. Avoid or Use Alternate Drug. imipramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.indacaterol, inhaledMonitor Closely (1)epinephrine increases effects of indacaterol, inhaled by Other (see comment). Use Caution/Monitor. Comment: If additional adrenergic drugs are to be administered by any route, they should be used with caution because the sympathetic effects of indacaterol may be potentiated.indapamideContraindicated (1)epinephrine and indapamide both increase QTc interval. Contraindicated.Monitor Closely (1)epinephrine and indapamide both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.indomethacinMonitor Closely (1)indomethacin increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.insulin degludecMonitor Closely (1)epinephrine decreases effects of insulin degludec by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Sympathomimetics increase blood glucose by stimulating alpha and beta receptors; this action results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.insulin degludec/insulin aspartMonitor Closely (1)epinephrine decreases effects of insulin degludec/insulin aspart by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Sympathomimetics increase blood glucose by stimulating alpha and beta receptors; this action results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.insulin inhaledMonitor Closely (1)epinephrine decreases effects of insulin inhaled by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Sympathomimetics increase blood glucose by stimulating alpha and beta receptors; this action results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.iobenguane I 123Contraindicated (1)epinephrine decreases effects of iobenguane I 123 by receptor binding competition. Contraindicated. If clinically appropriate, discontinue drugs that compete for NE receptor sites for at least 5 half-lives; may cause false-negative imaging results.iobenguane I 131Serious - Use Alternative (1)epinephrine will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.isocarboxazidContraindicated (1)isocarboxazid increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.isofluraneSerious - Use Alternative (1)isoflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.isoproterenolMonitor Closely (3)epinephrine and isoproterenol both decrease serum potassium. Use Caution/Monitor. epinephrine and isoproterenol both decrease sedation. Use Caution/Monitor. epinephrine and isoproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.ketamineSerious - Use Alternative (1)ketamine, epinephrine. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Intraoperative use of epinephrine and ketamine should be used cautiously and is contraindicated in situations where increased blood pressure would be hazardous (eg, hypertension, stroke, head trauma, intracranial bleeding).ketoconazoleSerious - Use Alternative (1)epinephrine and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.ketoprofenMonitor Closely (1)ketoprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolacMonitor Closely (1)ketorolac increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketorolac intranasalMonitor Closely (1)ketorolac intranasal increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .ketotifen, ophthalmicMonitor Closely (1)ketotifen, ophthalmic increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.labetalolMonitor Closely (2)labetalol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. labetalol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.levalbuterolMonitor Closely (3)epinephrine and levalbuterol both decrease serum potassium. Use Caution/Monitor. epinephrine and levalbuterol both decrease sedation. Use Caution/Monitor. epinephrine and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.levofloxacinMonitor Closely (1)epinephrine and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levoketoconazoleSerious - Use Alternative (1)epinephrine and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranSerious - Use Alternative (1)levomilnacipran increases levels of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of paroxysmal HTN, arrhythmia.levorphanolMonitor Closely (1)levorphanol increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levothyroxineMonitor Closely (1)levothyroxine will increase the level or effect of epinephrine by unspecified interaction mechanism. Use Caution/Monitor.linezolidContraindicated (1)linezolid increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lisdexamfetamineMonitor Closely (2)epinephrine and lisdexamfetamine both decrease sedation. Use Caution/Monitor. epinephrine and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.lofepramineMonitor Closely (2)lofepramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. lofepramine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and lofepramine both increase QTc interval. Avoid or Use Alternate Drug. lofepramine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lofexidineMonitor Closely (1)lofexidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loprazolamMonitor Closely (1)loprazolam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lormetazepamMonitor Closely (1)lormetazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lornoxicamMonitor Closely (1)lornoxicam increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapineMonitor Closely (1)loxapine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)loxapine inhaled increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lumefantrineSerious - Use Alternative (1)epinephrine and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.lurasidoneContraindicated (1)epinephrine increases toxicity of lurasidone by pharmacodynamic synergism. Contraindicated. Interaction applies only in setting of acute lurasidone overdose. Epinephrine may enhance hypotensive effects of lurasidone in overdose setting.maprotilineMonitor Closely (2)maprotiline increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. maprotiline increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug. maprotiline, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.marijuanaMonitor Closely (1)marijuana increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meclofenamateMonitor Closely (1)meclofenamate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.mefenamic acidMonitor Closely (1)mefenamic acid increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.melatoninMonitor Closely (1)melatonin increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meloxicamMonitor Closely (1)meloxicam increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.meperidineMonitor Closely (1)meperidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meprobamateMonitor Closely (1)meprobamate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaproterenolMonitor Closely (3)epinephrine and metaproterenol both decrease serum potassium. Use Caution/Monitor. epinephrine and metaproterenol both decrease sedation. Use Caution/Monitor. epinephrine and metaproterenol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methadoneMonitor Closely (2)epinephrine and methadone both increase QTc interval. Modify Therapy/Monitor Closely. methadone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methamphetamineMonitor Closely (2)epinephrine and methamphetamine both decrease sedation. Use Caution/Monitor. epinephrine and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.methoxyfluraneSerious - Use Alternative (1)methoxyflurane increases toxicity of epinephrine by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of V tach, HTN.methyclothiazideMonitor Closely (1)epinephrine and methyclothiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)epinephrine,