be required when used concomitantly. amoxapine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (2)amoxapine and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. amoxapine and clomipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and clomipramine both increase QTc interval. Avoid or Use Alternate Drug. amoxapine and clomipramine both increase serotonin levels. Avoid or Use Alternate Drug.clonazepamMonitor Closely (1)clonazepam and amoxapine both increase sedation. Use Caution/Monitor.clonidineSerious - Use Alternative (1)amoxapine decreases effects of clonidine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.clorazepateMonitor Closely (1)clorazepate and amoxapine both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (3)clozapine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. clozapine and amoxapine both increase sedation. Use Caution/Monitor. clozapine and amoxapine both increase QTc interval. Use Caution/Monitor.cobicistatMonitor Closely (2)cobicistat will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Carefully titrate antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant response cobicistat will increase the level or effect of amoxapine by Other (see comment). Use Caution/Monitor. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. cocaine topicalMonitor Closely (1)amoxapine and cocaine topical both increase serotonin levels. Modify Therapy/Monitor Closely.codeineMonitor Closely (1)codeine and amoxapine both increase sedation. Use Caution/Monitor.conjugated estrogensMinor (1)conjugated estrogens, amoxapine. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.conjugated estrogens, vaginalMinor (1)conjugated estrogens, vaginal, amoxapine. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.crizotinibMonitor Closely (1)crizotinib and amoxapine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.cyclizineMonitor Closely (2)cyclizine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. cyclizine and amoxapine both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (2)cyclobenzaprine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. cyclobenzaprine and amoxapine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine and cyclobenzaprine both increase serotonin levels. Avoid or Use Alternate Drug.cyproheptadineMonitor Closely (1)cyproheptadine and amoxapine both increase sedation. Use Caution/Monitor.dacomitinibSerious - Use Alternative (1)dacomitinib will increase the level or effect of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. dantroleneMonitor Closely (1)dantrolene and amoxapine both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)amoxapine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darifenacinMonitor Closely (1)darifenacin and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.dasatinibMonitor Closely (1)amoxapine and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.debrisoquineMonitor Closely (1)amoxapine decreases effects of debrisoquine by Other (see comment). Use Caution/Monitor. Comment: Inhibition of uptake by adrenergic neurons.desfluraneMonitor Closely (1)desflurane and amoxapine both increase sedation. Use Caution/Monitor.Minor (1)desflurane, amoxapine. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.desipramineMonitor Closely (2)amoxapine and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. amoxapine and desipramine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and desipramine both increase QTc interval. Avoid or Use Alternate Drug. amoxapine and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.desvenlafaxineSerious - Use Alternative (1)amoxapine and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.deutetrabenazineMonitor Closely (2)amoxapine and deutetrabenazine both increase sedation. Use Caution/Monitor. deutetrabenazine and amoxapine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and amoxapine both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (2)amoxapine and dexfenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely. amoxapine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dexmedetomidineMonitor Closely (1)dexmedetomidine and amoxapine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)amoxapine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of amoxapine by decreasing metabolism. Minor/Significance Unknown.dextroamphetamineMonitor Closely (3)amoxapine increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor. amoxapine and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely. amoxapine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dextroamphetamine transdermalMonitor Closely (1)amoxapine will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. Modify Therapy/Monitor Closely. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. Monitor frequently and adjust or use an alternant based on clinical response.dextromethorphanSerious - Use Alternative (1)amoxapine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.dextromoramideMonitor Closely (1)dextromoramide and amoxapine both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine and amoxapine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and amoxapine both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, amoxapine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.dicyclomineMonitor Closely (1)dicyclomine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.diethylpropionMonitor Closely (1)amoxapine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.difelikefalinMonitor Closely (1)difelikefalin and amoxapine both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl and amoxapine both increase sedation. Use Caution/Monitor.dihydroergotamineMonitor Closely (1)amoxapine and dihydroergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.dihydroergotamine intranasalMonitor Closely (1)amoxapine and dihydroergotamine intranasal both increase serotonin levels. Modify Therapy/Monitor Closely.dimenhydrinateMonitor Closely (1)dimenhydrinate and amoxapine both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (2)diphenhydramine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor. diphenhydramine and amoxapine both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl and amoxapine both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone and amoxapine both increase sedation. Use Caution/Monitor.disopyramideContraindicated (1)amoxapine and disopyramide both increase QTc interval. Contraindicated.dobutamineMonitor Closely (1)amoxapine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dofetilideMonitor Closely (1)dofetilide increases toxicity of amoxapine by QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.dolasetronMonitor Closely (1)amoxapine and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)dolasetron, amoxapine. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.donepezilMonitor Closely (1)donepezil increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)donepezil and amoxapine both increase QTc interval. Avoid or Use Alternate Drug.dopamineMonitor Closely (1)amoxapine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dopexamineMonitor Closely (1)amoxapine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dosulepinMonitor Closely (2)amoxapine and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor. amoxapine and dosulepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and dosulepin both increase QTc interval. Avoid or Use Alternate Drug. amoxapine and dosulepin both increase serotonin levels. Avoid or Use Alternate Drug.doxepinMonitor Closely (2)amoxapine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. amoxapine and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. amoxapine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.doxylamineMonitor Closely (1)doxylamine and amoxapine both increase sedation. Use Caution/Monitor.dronedaroneSerious - Use Alternative (1)amoxapine and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.droperidolMonitor Closely (2)droperidol and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor. droperidol and amoxapine both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.duloxetineSerious - Use Alternative (1)duloxetine and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.echothiophate iodideMonitor Closely (1)echothiophate iodide increases and amoxapine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.eletriptanMonitor Closely (1)eletriptan and amoxapine both increase serotonin levels. Modify Therapy/Monitor Closely.eliglustatMonitor Closely (1)eliglustat increases levels of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.elvitegravir/cobicistat/emtricitabine/tenofovir DFMonitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of amoxapine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.ephedrineMonitor Closely (2)amoxapine increases effects of ephedrine by unknown mechanism. Use Caution/Monitor. amoxapine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrineMonitor Closely (2)amoxapine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. amoxapine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and amoxapine both increase QTc interval. Avoid or Use Alternate Drug. amoxapine, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.epinephrine inhaledMonitor Closely (1)amoxapine and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system.epinephrine racemicMonitor Closely (2)amoxapine increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor. amoxapine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine racemic and amoxapine both increase QTc interval. Avoid or Use Alternate Drug. amoxapine, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.ergotamineMonitor Closely (1)amoxapine and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.erythromycin baseSerious - Use Alternative (1)amoxapine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateSerious - Use Alternative (1)amoxapine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateSerious - Use Alternative (1)amoxapine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateSerious - Use Alternative (1)amoxapine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.escitalopramMonitor Closely (1)escitalopram increases toxicity of amoxapine by QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)escitalopram and amoxapine both increase serotonin