interaction is not clear, use caution. Use Caution/Monitor.dopexaminenortriptyline increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepindoxepin and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepin and nortriptyline both increase sedation. Use Caution/Monitor.doxylaminedoxylamine and nortriptyline both increase sedation. Use Caution/Monitor.droperidoldroperidol and nortriptyline both increase sedation. Use Caution/Monitor.duloxetineduloxetine will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.echothiophate iodideechothiophate iodide increases and nortriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.efavirenzefavirenz and nortriptyline both increase QTc interval. Use Caution/Monitor.eletriptaneletriptan and nortriptyline both increase serotonin levels. Modify Therapy/Monitor Closely.eliglustateliglustat increases levels of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.eliglustat and nortriptyline both increase QTc interval. Use Caution/Monitor.entrectinibentrectinib and nortriptyline both increase QTc interval. Use Caution/Monitor.ephedrinenortriptyline increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptyline increases effects of ephedrine by unknown mechanism. Use Caution/Monitor.epinephrinenortriptyline increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptyline increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.epinephrine inhalednortriptyline and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system.epinephrine racemicnortriptyline increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptyline increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor.ergotaminenortriptyline and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.eribulineribulin and nortriptyline both increase QTc interval. Use Caution/Monitor.escitalopramescitalopram increases toxicity of nortriptyline by QTc interval. Use Caution/Monitor.esketamine intranasalesketamine intranasal, nortriptyline. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.estazolamestazolam and nortriptyline both increase sedation. Use Caution/Monitor.ethanolnortriptyline and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and nortriptyline both increase sedation. Use Caution/Monitor.ezogabineezogabine, nortriptyline. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.fedratinibfedratinib will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary.fenfluraminenortriptyline increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptyline and fenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.fenfluramine, nortriptyline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome.fesoterodinefesoterodine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.fingolimodfingolimod and nortriptyline both increase QTc interval. Use Caution/Monitor.flavoxateflavoxate and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.flecainidenortriptyline and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.fluoxetinenortriptyline and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazinefluphenazine and nortriptyline both increase sedation. Use Caution/Monitor.flurazepamflurazepam and nortriptyline both increase sedation. Use Caution/Monitor.fluvoxaminefluvoxamine and nortriptyline both increase QTc interval. Modify Therapy/Monitor Closely.formoterolnortriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.foscarnetnortriptyline and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.fostemsavirnortriptyline and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. frovatriptanfrovatriptan and nortriptyline both increase serotonin levels. Modify Therapy/Monitor Closely.gabapentingabapentin, nortriptyline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, nortriptyline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.galantaminegalantamine increases and nortriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.ganaxolonenortriptyline and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacingemifloxacin and nortriptyline both increase QTc interval. Use Caution/Monitor.gilteritinibgilteritinib and nortriptyline both increase QTc interval. Use Caution/Monitor.glycopyrrolateglycopyrrolate and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.nortriptyline increases levels of glycopyrrolate by unknown mechanism. Use Caution/Monitor.glycopyrrolate inhaledglycopyrrolate inhaled and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.nortriptyline increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor.glycopyrronium tosylate topicalglycopyrronium tosylate topical, nortriptyline. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.granisetrongranisetron and nortriptyline both increase QTc interval. Use Caution/Monitor.haloperidolhaloperidol and nortriptyline both increase sedation. Use Caution/Monitor.henbanehenbane and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.homatropinehomatropine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.huperzine Ahuperzine A increases and nortriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydrocodonehydrocodone, nortriptyline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.hydromorphonehydromorphone and nortriptyline both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and nortriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and nortriptyline both increase QTc interval. Use Caution/Monitor.hyoscyaminehyoscyamine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.hyoscyamine sprayhyoscyamine spray and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.iloperidonenortriptyline and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely.iloperidone and nortriptyline both increase sedation. Use Caution/Monitor.imatinibimatinib will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.imipramineimipramine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.imipramine and nortriptyline both increase sedation. Use Caution/Monitor.indacaterol, inhaledindacaterol, inhaled, nortriptyline. QTc interval. Use Caution/Monitor. Indacaterol should be administered with extreme caution to patients treated with TCAs. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias.ipratropiumipratropium and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.isofluraneisoflurane and nortriptyline both increase QTc interval. Use Caution/Monitor.isoniazidnortriptyline and isoniazid both increase serotonin levels. Modify Therapy/Monitor Closely.isoproterenolnortriptyline increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.itraconazoleitraconazole and nortriptyline both increase QTc interval. Use Caution/Monitor.ketamineketamine and nortriptyline both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicnortriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.L-tryptophannortriptyline and L-tryptophan both increase serotonin levels. Modify Therapy/Monitor Closely.lapatinibnortriptyline and lapatinib both increase QTc interval. Modify Therapy/Monitor Closely.lasmiditanlasmiditan, nortriptyline. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.nortriptyline increases effects of lasmiditan by serotonin levels. Use Caution/Monitor. Coadministration may increase risk of serotonin syndrome.lemborexantlemborexant, nortriptyline. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.levalbuterolnortriptyline increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levofloxacinnortriptyline and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levoketoconazolelevoketoconazole will increase the level or effect of nortriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.levorphanollevorphanol and nortriptyline both increase sedation. Use Caution/Monitor.levothyroxinelevothyroxine increases effects of nortriptyline by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.liothyronineliothyronine increases effects of nortriptyline by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.liotrixliotrix increases effects of nortriptyline by Other (see comment). Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias.lisdexamfetaminenortriptyline increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptyline, lisdexamfetamine. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s).lithiumnortriptyline and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.lithium and nortriptyline both increase QTc interval. Use Caution/Monitor.lofepraminelofepramine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.lofepramine and nortriptyline both increase sedation. Use Caution/Monitor.lofexidinenortriptyline and lofexidine both increase sedation. Use Caution/Monitor.nortriptyline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.loprazolamloprazolam and nortriptyline both increase sedation. Use Caution/Monitor.lorazepamlorazepam and nortriptyline both increase sedation. Use Caution/Monitor.lorcaserinlorcaserin will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.lormetazepamlormetazepam and nortriptyline both increase sedation. Use Caution/Monitor.loxapineloxapine and nortriptyline both increase sedation. Use Caution/Monitor.loxapine inhaledloxapine inhaled and nortriptyline both increase sedation. Use Caution/Monitor.lsdnortriptyline and lsd both increase serotonin levels. Modify Therapy/Monitor Closely.lurasidonelurasidone increases effects of nortriptyline by Other (see comment). Use Caution/Monitor. Comment: Potential for additive CNS effects .maprotilinemaprotiline and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.maprotiline and nortriptyline both increase sedation. Use Caution/Monitor.maravirocmaraviroc will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.marijuanamarijuana will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.nortriptyline and marijuana both increase sedation. Use Caution/Monitor.meclizinemeclizine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.melatoninnortriptyline and melatonin both increase sedation. Use Caution/Monitor.meperidinemeperidine and nortriptyline both increase sedation. Use Caution/Monitor.meprobamatenortriptyline and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolnortriptyline increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonemetaxalone and nortriptyline both increase sedation. Use Caution/Monitor.methadonenortriptyline and methadone both increase QTc interval. Modify Therapy/Monitor Closely.methadone and nortriptyline both increase sedation. Use Caution/Monitor.methamphetaminenortriptyline increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolmethocarbamol and nortriptyline both increase sedation. Use Caution/Monitor.methscopolaminemethscopolamine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.methylenedioxymethamphetaminenortriptyline increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidatenortriptyline, methylphenidate. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.methylphenidate transdermalmethylphenidate transdermal will increase the level or effect of nortriptyline by decreasing elimination. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. midazolammidazolam and nortriptyline both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, nortriptyline. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinenortriptyline increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristonemifepristone, nortriptyline. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.mirabegronmirabegron will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.mirtazapinenortriptyline and mirtazapine both increase sedation. Use Caution/Monitor.nortriptyline and mirtazapine both increase serotonin levels. Modify Therapy/Monitor Closely.modafinilnortriptyline increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinemorphine and nortriptyline both increase sedation. Use Caution/Monitor.nortriptyline and morphine both increase serotonin levels. Modify Therapy/Monitor Closely.motherwortnortriptyline and motherwort both increase sedation. Use Caution/Monitor.moxonidinenortriptyline and moxonidine both increase sedation. Use Caution/Monitor.nabilonenortriptyline and nabilone both increase sedation. Use Caution/Monitor.nalbuphinenalbuphine and nortriptyline both increase sedation. Use Caution/Monitor.naratriptannaratriptan and nortriptyline both increase serotonin levels. Modify Therapy/Monitor Closely.nefopamnefopam, nortriptyline. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Use combination with caution.neostigmineneostigmine increases and nortriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.nilotinibnilotinib will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.norepinephrinenortriptyline increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptyline increases effects of norepinephrine by unknown mechanism. Use Caution/Monitor.ofloxacinnortriptyline and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.olanzapineolanzapine and nortriptyline both increase sedation. Use Caution/Monitor.olanzapine and nortriptyline both increase QTc interval. Use Caution/Monitor.oliceridinenortriptyline, oliceridine. Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely.nortriptyline increases toxicity of oliceridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.olodaterol inhalednortriptyline and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. TCAs prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmiasonabotulinumtoxinAonabotulinumtoxinA and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.opium tinctureopium tincture and nortriptyline both increase sedation. Use Caution/Monitor.orphenadrinenortriptyline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and