AdultPediatricDosage Forms & Strengths injectable, powder for reconstitution 0.5mg/vial 1.5mg/vial Pulmonary Hypertension Initial: 2 ng/kg/min IV infusion pump over 24-48 hours; may initiate at lower dose if intolerant to starting dose Titrate by 1-2 ng/kg/min q15min or longer, until desired effect or dose-limiting pharmacologic effects occurDosage Forms & Strengths injectable, powder for reconstitution 0.5 mg 1.5 mg Pulmonary Hypertension (Off-label) Initial 2 ng/kg/min IV infusion pump over 24-48 hours initially; may initiate at lower dose if intolerant to starting dose Titrate by 1-2 ng/kg/min IV q15min or longer, until desired effect or dose-limiting pharmacologic effects occurInteraction CheckerEnter a drug name and epoprostenolNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (1)lofexidinelofexidine, epoprostenol. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.Monitor Closely (86)aceclofenacaceclofenac and epoprostenol both increase anticoagulation. Use Caution/Monitor.acemetacinacemetacin and epoprostenol both increase anticoagulation. Use Caution/Monitor.agrimonyagrimony and epoprostenol both increase anticoagulation. Use Caution/Monitor.aldesleukinaldesleukin increases effects of epoprostenol by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.alfalfaalfalfa and epoprostenol both increase anticoagulation. Use Caution/Monitor.alteplasealteplase and epoprostenol both increase anticoagulation. Use Caution/Monitor. Coadministration can increase the risk of bleeding, although this did not occur in clinical trials.American ginsengAmerican ginseng and epoprostenol both increase anticoagulation. Use Caution/Monitor.amifostineamifostine, epoprostenol. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.antithrombin alfaantithrombin alfa and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.antithrombin IIIantithrombin III and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.argatrobanargatroban and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.aspirinaspirin and epoprostenol both increase anticoagulation. Use Caution/Monitor.aspirin rectalaspirin rectal and epoprostenol both increase anticoagulation. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate and epoprostenol both increase anticoagulation. Use Caution/Monitor.bemiparinbemiparin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.benazeprilepoprostenol, benazepril. Either decreases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increases risk of hypotension.bivalirudinbivalirudin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.captoprilepoprostenol, captopril. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood pressure. Monitor blood pressure.carbidopacarbidopa increases effects of epoprostenol by pharmacodynamic synergism. Use Caution/Monitor. Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required.celecoxibcelecoxib and epoprostenol both increase anticoagulation. Use Caution/Monitor.choline magnesium trisalicylatecholine magnesium trisalicylate and epoprostenol both increase anticoagulation. Use Caution/Monitor.cinnamoncinnamon and epoprostenol both increase anticoagulation. Use Caution/Monitor.cordycepscordyceps and epoprostenol both increase anticoagulation. Use Caution/Monitor.dabigatrandabigatran and epoprostenol both increase anticoagulation. Use Caution/Monitor. Both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.dalteparindalteparin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.diclofenacdiclofenac and epoprostenol both increase anticoagulation. Use Caution/Monitor.diflunisaldiflunisal and epoprostenol both increase anticoagulation. Use Caution/Monitor.digoxinepoprostenol will increase the level or effect of digoxin by unspecified interaction mechanism. Use Caution/Monitor. Measure serum digoxin concentrations before initiating concomitant drugs; continue monitoring and reduce digoxin dose as necessarydong quaidong quai and epoprostenol both increase anticoagulation. Use Caution/Monitor.eluxadolineeluxadoline increases levels of epoprostenol by decreasing metabolism. Use Caution/Monitor. Eluxadoline may increase the systemic exposure of coadministered OATP1B1 substrates.enoxaparinenoxaparin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.etodolacetodolac and epoprostenol both increase anticoagulation. Use Caution/Monitor.fennelepoprostenol and fennel both increase anticoagulation. Use Caution/Monitor.fenoldopamepoprostenol, fenoldopam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.fenoprofenfenoprofen and epoprostenol both increase anticoagulation. Use Caution/Monitor.feverfewepoprostenol and feverfew both increase anticoagulation. Use Caution/Monitor.fish oil triglyceridesfish oil triglycerides will increase the level or effect of epoprostenol by anticoagulation. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants.flurbiprofenflurbiprofen and epoprostenol both increase anticoagulation. Use Caution/Monitor.fondaparinuxfondaparinux and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.forskolinepoprostenol and forskolin both increase anticoagulation. Use Caution/Monitor.garlicepoprostenol and garlic both increase anticoagulation. Use Caution/Monitor.gingerepoprostenol and ginger both increase anticoagulation. Use Caution/Monitor.ginkgo bilobaepoprostenol and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.heparinheparin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.horse chestnut seedepoprostenol and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.hydralazineepoprostenol, hydralazine. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.ibrutinibibrutinib will increase the level or effect of epoprostenol by anticoagulation. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding. ibuprofenibuprofen and epoprostenol both increase anticoagulation. Use Caution/Monitor.ibuprofen IVibuprofen IV and epoprostenol both increase anticoagulation. Use Caution/Monitor.iloprostepoprostenol, iloprost. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.indomethacinindomethacin and epoprostenol both increase anticoagulation. Use Caution/Monitor.ketoprofenketoprofen and epoprostenol both increase anticoagulation. Use Caution/Monitor.ketorolacketorolac and epoprostenol both increase anticoagulation. Use Caution/Monitor.ketorolac intranasalketorolac intranasal and epoprostenol both increase anticoagulation. Use Caution/Monitor.levodopalevodopa increases effects of epoprostenol by pharmacodynamic synergism. Use Caution/Monitor. Consider decreasing dosage of antihypertensive agent.lornoxicamlornoxicam and epoprostenol both increase anticoagulation. Use Caution/Monitor.meclofenamatemeclofenamate and epoprostenol both increase anticoagulation. Use Caution/Monitor.mefenamic acidmefenamic acid and epoprostenol both increase anticoagulation. Use Caution/Monitor.meloxicammeloxicam and epoprostenol both increase anticoagulation. Use Caution/Monitor.minoxidilepoprostenol, minoxidil. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.mistletoeepoprostenol increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nabumetonenabumetone and epoprostenol both increase anticoagulation. Use Caution/Monitor.naproxennaproxen and epoprostenol both increase anticoagulation. Use Caution/Monitor.nettleepoprostenol increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxaprozinoxaprozin and epoprostenol both increase anticoagulation. Use Caution/Monitor.panax ginsengepoprostenol and panax ginseng both increase anticoagulation. Use Caution/Monitor.parecoxibparecoxib and epoprostenol both increase anticoagulation. Use Caution/Monitor.pau d'arcoepoprostenol and pau d'arco both increase anticoagulation. Use Caution/Monitor.phenindionephenindione and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.phytoestrogensepoprostenol and phytoestrogens both increase anticoagulation. Use Caution/Monitor.piroxicampiroxicam and epoprostenol both increase anticoagulation. Use Caution/Monitor.protamineprotamine and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.reishiepoprostenol and reishi both increase anticoagulation. Use Caution/Monitor.reteplasereteplase and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.salicylates (non-asa)salicylates (non-asa) and epoprostenol both increase anticoagulation. Use Caution/Monitor.salsalatesalsalate and epoprostenol both increase anticoagulation. Use Caution/Monitor.Siberian ginsengepoprostenol and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.sildenafilepoprostenol increases effects of sildenafil by additive vasodilation. Use Caution/Monitor. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy.sulfasalazinesulfasalazine and epoprostenol both increase anticoagulation. Use Caution/Monitor.sulindacsulindac and epoprostenol both increase anticoagulation. Use Caution/Monitor.tenecteplasetenecteplase and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.tolfenamic acidtolfenamic acid and epoprostenol both increase anticoagulation. Use Caution/Monitor.tolmetintolmetin and epoprostenol both increase anticoagulation. Use Caution/Monitor.treprostinilepoprostenol, treprostinil. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.warfarinepoprostenol, warfarin. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Drugs with antiplatelet properties may increase anticoagulation effect of warfarin.xipamidexipamide increases effects of epoprostenol by pharmacodynamic synergism. Use Caution/Monitor.Minor (28)agrimonyagrimony increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.amilorideepoprostenol increases effects of amiloride by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.anamuanamu and epoprostenol both increase anticoagulation. Minor/Significance Unknown.bendroflumethiazideepoprostenol increases effects of bendroflumethiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.brimonidinebrimonidine increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.bumetanideepoprostenol increases effects of bumetanide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.chlorothiazideepoprostenol increases effects of chlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.chlorthalidoneepoprostenol increases effects of chlorthalidone by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.cornsilkcornsilk increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.cyclopenthiazideepoprostenol increases effects of cyclopenthiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.danshendanshen and epoprostenol both increase anticoagulation. Minor/Significance Unknown.devil's clawdevil's claw and epoprostenol both increase anticoagulation. Minor/Significance Unknown.drospirenoneepoprostenol increases effects of drospirenone by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.ethacrynic acidepoprostenol increases effects of ethacrynic acid by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.forskolinforskolin increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.furosemideepoprostenol increases effects of furosemide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.hydrochlorothiazideepoprostenol increases effects of hydrochlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.indapamideepoprostenol increases effects of indapamide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.maitakemaitake increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown. Maitake mushroom has anti-tumor effects (animal/in vitro research).methyclothiazideepoprostenol increases effects of methyclothiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.metolazoneepoprostenol increases effects of metolazone by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.reishireishi increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.shepherd's purseshepherd's purse, epoprostenol. Other (see comment). Minor/Significance Unknown. Comment: Theoretically, shepherd's purse may interfere with BP control.spironolactoneepoprostenol increases effects of spironolactone by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.tizanidinetizanidine increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypotension.torsemideepoprostenol increases effects of torsemide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.treprostiniltreprostinil increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.triamtereneepoprostenol increases effects of triamterene by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.aceclofenacMonitor Closely (1)aceclofenac and epoprostenol both increase anticoagulation. Use Caution/Monitor.acemetacinMonitor Closely (1)acemetacin and epoprostenol both increase anticoagulation. Use Caution/Monitor.agrimonyMonitor Closely (1)agrimony and epoprostenol both increase anticoagulation. Use Caution/Monitor.Minor (1)agrimony increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.aldesleukinMonitor Closely (1)aldesleukin increases effects of epoprostenol by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.alfalfaMonitor Closely (1)alfalfa and epoprostenol both increase anticoagulation. Use Caution/Monitor.alteplaseMonitor Closely (1)alteplase and epoprostenol both increase anticoagulation. Use Caution/Monitor. Coadministration can increase the risk of bleeding, although this did not occur in clinical trials.American ginsengMonitor Closely (1)American ginseng and epoprostenol both increase anticoagulation. Use Caution/Monitor.amifostineMonitor Closely (1)amifostine, epoprostenol. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.amilorideMinor (1)epoprostenol increases effects of amiloride by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.anamuMinor (1)anamu and epoprostenol both increase anticoagulation. Minor/Significance Unknown.antithrombin alfaMonitor Closely (1)antithrombin alfa and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.antithrombin IIIMonitor Closely (1)antithrombin III and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.argatrobanMonitor Closely (1)argatroban and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.aspirinMonitor Closely (1)aspirin and epoprostenol both increase anticoagulation. Use Caution/Monitor.aspirin rectalMonitor Closely (1)aspirin rectal and epoprostenol both increase anticoagulation. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonateMonitor Closely (1)aspirin/citric acid/sodium bicarbonate and epoprostenol both increase anticoagulation. Use Caution/Monitor.bemiparinMonitor Closely (1)bemiparin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.benazeprilMonitor Closely (1)epoprostenol, benazepril. Either decreases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increases risk of hypotension.bendroflumethiazideMinor (1)epoprostenol increases effects of bendroflumethiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.bivalirudinMonitor Closely (1)bivalirudin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.brimonidineMinor (1)brimonidine increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.bumetanideMinor (1)epoprostenol increases effects of bumetanide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.captoprilMonitor Closely (1)epoprostenol, captopril. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood pressure. Monitor blood pressure.carbidopaMonitor Closely (1)carbidopa increases effects of epoprostenol by pharmacodynamic synergism. Use Caution/Monitor. Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required.celecoxibMonitor Closely (1)celecoxib and epoprostenol both increase anticoagulation. Use Caution/Monitor.chlorothiazideMinor (1)epoprostenol increases effects of chlorothiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.chlorthalidoneMinor (1)epoprostenol increases effects of chlorthalidone by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.choline magnesium trisalicylateMonitor Closely (1)choline magnesium trisalicylate and epoprostenol both increase anticoagulation. Use Caution/Monitor.cinnamonMonitor Closely (1)cinnamon and epoprostenol both increase anticoagulation. Use Caution/Monitor.cordycepsMonitor Closely (1)cordyceps and epoprostenol both increase anticoagulation. Use Caution/Monitor.cornsilkMinor (1)cornsilk increases effects of epoprostenol by pharmacodynamic synergism. Minor/Significance Unknown.cyclopenthiazideMinor (1)epoprostenol increases effects of cyclopenthiazide by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.dabigatranMonitor Closely (1)dabigatran and epoprostenol both increase anticoagulation. Use Caution/Monitor. Both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.dalteparinMonitor Closely (1)dalteparin and epoprostenol both increase anticoagulation. Modify Therapy/Monitor Closely.danshenMinor (1)danshen and epoprostenol both increase anticoagulation. Minor/Significance Unknown.devil's clawMinor (1)devil's claw and epoprostenol both increase anticoagulation. Minor/Significance Unknown.diclofenacMonitor Closely (1)diclofenac and epoprostenol both increase anticoagulation. Use Caution/Monitor.diflunisalMonitor Closely (1)diflunisal and epoprostenol both increase anticoagulation. Use Caution/Monitor.digoxinMonitor Closely (1)epoprostenol will increase the level or effect of digoxin by unspecified interaction mechanism. Use Caution/Monitor. Measure serum digoxin concentrations before initiating concomitant drugs; continue monitoring and reduce digoxin dose as necessarydong quaiMonitor Closely (1)dong quai and epoprostenol both increase anticoagulation. Use Caution/Monitor.drospirenoneMinor (1)epoprostenol increases effects