diminish antihypertensive effect.olmesartan, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.oteseconazoleoteseconazole will increase the level or effect of sulfasalazine by Other (see comment). Modify Therapy/Monitor Closely. Otesezonale, a BCRP inhibitor, may increase the effects and risk of toxicities of BCRP substrates. Use lowest starting dose of BCRP substrate, or consider reducing BCRP substrate dose.oxaprozinoxaprozin and sulfasalazine both increase anticoagulation. Use Caution/Monitor.oxaprozin and sulfasalazine both increase serum potassium. Use Caution/Monitor.panax ginsengsulfasalazine and panax ginseng both increase anticoagulation. Use Caution/Monitor.parecoxibparecoxib and sulfasalazine both increase anticoagulation. Use Caution/Monitor.parecoxib and sulfasalazine both increase serum potassium. Use Caution/Monitor.paroxetineparoxetine, sulfasalazine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.pau d'arcosulfasalazine and pau d'arco both increase anticoagulation. Use Caution/Monitor.pegaspargasepegaspargase increases effects of sulfasalazine by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of bleeding events.penbutololpenbutolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.perindoprilsulfasalazine decreases effects of perindopril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.perindopril, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.phenindionephenindione and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.phenoxybenzaminesulfasalazine decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.phentolaminesulfasalazine decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.phytoestrogenssulfasalazine and phytoestrogens both increase anticoagulation. Use Caution/Monitor.pindololpindolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.pirbuterolsulfasalazine increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.piroxicampiroxicam and sulfasalazine both increase anticoagulation. Use Caution/Monitor.piroxicam and sulfasalazine both increase serum potassium. Use Caution/Monitor.pivmecillinampivmecillinam, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.pivmecillinam, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.ponatinibponatinib increases levels of sulfasalazine by Other (see comment). Use Caution/Monitor.potassium acid phosphatesulfasalazine and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.potassium chloridesulfasalazine and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.potassium citratesulfasalazine and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.prazosinsulfasalazine decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.prednisolonesulfasalazine, prednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.prednisonesulfasalazine, prednisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.probenecidsulfasalazine will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.sulfasalazine decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.propranololpropranolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.protamineprotamine and sulfasalazine both increase anticoagulation. Modify Therapy/Monitor Closely.quinaprilsulfasalazine decreases effects of quinapril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.quinapril, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ramiprilsulfasalazine decreases effects of ramipril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.ramipril, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.regorafenibregorafenib will increase the level or effect of sulfasalazine by Other (see comment). Modify Therapy/Monitor Closely. Regorafenib likely inhibits BCRP (ABCG2) transport. Coadministration with a BCRP substrate may increase systemic exposure to the substrate and related toxicity.reishisulfasalazine and reishi both increase anticoagulation. Use Caution/Monitor.sacubitril/valsartansacubitril/valsartan and sulfasalazine both increase serum potassium. Use Caution/Monitor.sacubitril/valsartan, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.sulfasalazine decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.safinamidesafinamide will increase the level or effect of sulfasalazine by Other (see comment). Use Caution/Monitor. Safinamide and its major metabolite may inhibit intestinal BCRP. Monitor BCRP substrates for increased pharmacologic or adverse effects.salicylates (non-asa)salicylates (non-asa) and sulfasalazine both increase anticoagulation. Use Caution/Monitor.salicylates (non-asa) and sulfasalazine both increase serum potassium. Use Caution/Monitor.salmeterolsulfasalazine increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.salsalatesalsalate and sulfasalazine both increase anticoagulation. Use Caution/Monitor.salsalate and sulfasalazine both increase serum potassium. Use Caution/Monitor.sertralinesertraline, sulfasalazine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.Siberian ginsengsulfasalazine and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.silodosinsulfasalazine decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.sodium picosulfate/magnesium oxide/anhydrous citric acidsulfasalazine, sodium picosulfate/magnesium oxide/anhydrous citric acid. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May be associated with fluid and electrolyte imbalances.sofosbuvir/velpatasvirsofosbuvir/velpatasvir will increase the level or effect of sulfasalazine by Other (see comment). Use Caution/Monitor. Velpatasvir is an inhibitor of the drug transporter BCRP. Coadministration may increase systemic exposure of drugs that are BCRP substrates.sotalolsotalol and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.spironolactonespironolactone and sulfasalazine both increase serum potassium. Modify Therapy/Monitor Closely.stiripentolstiripentol will increase the level or effect of sulfasalazine by Other (see comment). Use Caution/Monitor. Stiripentol is a BCRP transport inhibitor. Consider dosage reduction for BCRP substrates if adverse effects are experienced when coadministered.succinylcholinesulfasalazine and succinylcholine both increase serum potassium. Use Caution/Monitor.sulindacsulfasalazine and sulindac both increase anticoagulation. Use Caution/Monitor.sulfasalazine and sulindac both increase serum potassium. Use Caution/Monitor.tafamidistafamidis will increase the level or effect of sulfasalazine by Other (see comment). Use Caution/Monitor. Tafamidis inhibits breast cancer resistant protein (BCRP) in vitro and may increase exposure of BCRP substrates following tafamidis or tafamidis meglumine administration. Dosage adjustment of these BCRP substrates may be necessary.tafamidis megluminetafamidis meglumine will increase the level or effect of sulfasalazine by Other (see comment). Use Caution/Monitor. Tafamidis inhibits breast cancer resistant protein (BCRP) in vitro and may increase exposure of BCRP substrates following tafamidis or tafamidis meglumine administration. Dosage adjustment of these BCRP substrates may be necessary.telmisartantelmisartan and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of telmisartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.telmisartan, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.temocillintemocillin, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.temocillin, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.terazosinsulfasalazine decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.terbutalinesulfasalazine increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ticarcillinticarcillin, sulfasalazine. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.ticarcillin, sulfasalazine. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.timololtimolol and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.tobramycin inhaledtobramycin inhaled and sulfasalazine both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicitytolazamidesulfasalazine increases effects of tolazamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.tolbutamidesulfasalazine increases effects of tolbutamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.tolfenamic acidsulfasalazine and tolfenamic acid both increase anticoagulation. Use Caution/Monitor.sulfasalazine and tolfenamic acid both increase serum potassium. Use Caution/Monitor.tolmetinsulfasalazine and tolmetin both increase anticoagulation. Use Caution/Monitor.sulfasalazine and tolmetin both increase serum potassium. Use Caution/Monitor.tolvaptansulfasalazine and tolvaptan both increase serum potassium. Use Caution/Monitor.torsemidesulfasalazine increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodonetrazodone, sulfasalazine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.triamcinolone acetonide injectable suspensionsulfasalazine, triamcinolone acetonide injectable suspension. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.triamterenetriamterene and sulfasalazine both increase serum potassium. Modify Therapy/Monitor Closely.valoctocogene roxaparvovecsulfasalazine and valoctocogene roxaparvovec both increase Other (see comment). Use Caution/Monitor. Medications that may cause hepatotoxicity when combined with valoctogene roxaparvovec may potentiate the risk of elevated liver enzymes. Closely monitor these medications and consider alternative medications in case of potential drug interactions.valsartanvalsartan and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, sulfasalazine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.venlafaxinevenlafaxine, sulfasalazine. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.vitamin K1 (phytonadione)sulfasalazine increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.voclosporinvoclosporin, sulfasalazine. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.warfarinsulfasalazine increases effects of warfarin by anticoagulation. Use Caution/Monitor.zotepinesulfasalazine decreases effects of zotepine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.Minor (115)aceclofenacaceclofenac will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.acemetacinacemetacin will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.acyclovirsulfasalazine will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.alendronatesulfasalazine, alendronate. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI ulceration.aluminum hydroxidealuminum hydroxide, sulfasalazine. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).amikacinsulfasalazine increases levels of amikacin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.aminohippurate sodiumsulfasalazine will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.anamusulfasalazine and anamu both increase anticoagulation. Minor/Significance Unknown.aspirinaspirin will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.aspirin rectalaspirin rectal will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.aspirin/citric acid/sodium bicarbonateaspirin/citric acid/sodium bicarbonate will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.balsalazidesulfasalazine will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.bendroflumethiazidebendroflumethiazide will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.budesonidebudesonide decreases levels of sulfasalazine by increasing renal clearance. Minor/Significance Unknown.bumetanidesulfasalazine, bumetanide. Other (see comment). Minor/Significance Unknown. Comment: Salicylates are less likely than other NSAIDs to interact w/bumetanide.calcium carbonatecalcium carbonate, sulfasalazine. Mechanism: passive renal tubular reabsorption due to increased pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).cefaclorcefaclor will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefadroxilcefadroxil will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefamandolecefamandole will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefazolincefazolin will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefepimecefepime will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.cefotaximecefotaxime