Use Caution/Monitor.prochlorperazine and amoxapine both increase sedation. Use Caution/Monitor.anagrelideanagrelide and prochlorperazine both decrease QTc interval. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.anticholinergic/sedative combos decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.apomorphineprochlorperazine and apomorphine both increase sedation. Use Caution/Monitor.arformoterolprochlorperazine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazolearipiprazole and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.aripiprazole and prochlorperazine both increase sedation. Use Caution/Monitor.armodafinilprochlorperazine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.artemether/lumefantrineartemether/lumefantrine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapineasenapine and prochlorperazine both decrease QTc interval. Use Caution/Monitor.asenapine and prochlorperazine both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and prochlorperazine both decrease QTc interval. Use Caution/Monitor.asenapine transdermal and prochlorperazine both increase sedation. Use Caution/Monitor.atracuriumatracurium decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atracurium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of atracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropineatropine decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of atropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IMprochlorperazine increases effects of atropine IV/IM by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IM decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine IV/IM decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.avapritinibavapritinib and prochlorperazine both increase sedation. Use Caution/Monitor.azelastineazelastine and prochlorperazine both increase sedation. Use Caution/Monitor.azithromycinprochlorperazine and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenbaclofen and prochlorperazine both increase sedation. Use Caution/Monitor.belladonna alkaloidsbelladonna alkaloids decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna alkaloids decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of belladonna alkaloids by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.belladonna and opiumbelladonna and opium and prochlorperazine both increase sedation. Use Caution/Monitor.belladonna and opium decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna and opium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of belladonna and opium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benperidolbenperidol and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.benperidol and prochlorperazine both increase sedation. Use Caution/Monitor.benzphetamineprochlorperazine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, benzphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.benztropineprochlorperazine increases effects of benztropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. .brexanolonebrexanolone, prochlorperazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and prochlorperazine both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and prochlorperazine both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and prochlorperazine both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and prochlorperazine both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and prochlorperazine both increase sedation. Use Caution/Monitor.buprenorphine and prochlorperazine both decrease QTc interval. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and prochlorperazine both increase sedation. Use Caution/Monitor.buprenorphine buccal and prochlorperazine both decrease QTc interval. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and prochlorperazine both decrease QTc interval. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and prochlorperazine both decrease QTc interval. Use Caution/Monitor.buprenorphine, long-acting injectionprochlorperazine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.buprenorphine, long-acting injection and prochlorperazine both decrease QTc interval. Use Caution/Monitor.bupropionbupropion will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.prochlorperazine increases toxicity of bupropion by unspecified interaction mechanism. Use Caution/Monitor. May lower seizure threshold; keep bupropion dose as low as possible.butabarbitalbutabarbital and prochlorperazine both increase sedation. Use Caution/Monitor.butalbitalbutalbital and prochlorperazine both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and prochlorperazine both increase sedation. Use Caution/Monitor.caffeineprochlorperazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and prochlorperazine both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and prochlorperazine both increase sedation. Use Caution/Monitor.cenobamatecenobamate, prochlorperazine. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydratechloral hydrate and prochlorperazine both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and prochlorperazine both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and prochlorperazine both increase sedation. Use Caution/Monitor.chlorpromazinechlorpromazine and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.chlorpromazine and prochlorperazine both increase sedation. Use Caution/Monitor.chlorzoxazonechlorzoxazone and prochlorperazine both increase sedation. Use Caution/Monitor.cigarette smokingcigarette smoking decreases levels of prochlorperazine by increasing metabolism. Use Caution/Monitor. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines.cinnarizinecinnarizine and prochlorperazine both increase sedation. Use Caution/Monitor.cisatracuriumcisatracurium decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.cisatracurium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of cisatracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.citalopramcitalopram and prochlorperazine both increase serotonin levels. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.clemastineclemastine and prochlorperazine both increase sedation. Use Caution/Monitor.clobazamprochlorperazine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineprochlorperazine and clomipramine both increase QTc interval. Use Caution/Monitor.prochlorperazine and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and prochlorperazine both increase sedation. Use Caution/Monitor.clonidineclonidine, prochlorperazine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Additive hypotensive effects; potential delirium.clorazepateclorazepate and prochlorperazine both increase sedation. Use Caution/Monitor.clozapineclozapine and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.clozapine and prochlorperazine both increase sedation. Use Caution/Monitor.codeinecodeine and prochlorperazine both increase sedation. Use Caution/Monitor.cyclizinecyclizine and prochlorperazine both increase sedation. Use Caution/Monitor.cyclizine decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.cyclizine decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cyclobenzaprinecyclobenzaprine and prochlorperazine both increase sedation. Use Caution/Monitor.cyclobenzaprine decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.cyclobenzaprine decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of cyclobenzaprine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cyproheptadinecyproheptadine and prochlorperazine both increase sedation. Use Caution/Monitor.dantrolenedantrolene and prochlorperazine both increase sedation. Use Caution/Monitor.daridorexantprochlorperazine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darifenacindarifenacin decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.darifenacin decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of darifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.dasatinibprochlorperazine and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.deferoxaminedeferoxamine, prochlorperazine. Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Synergistic increase in neurological adverse effects.desfluranedesflurane and prochlorperazine both increase sedation. Use Caution/Monitor.desflurane and prochlorperazine both decrease QTc interval. Use Caution/Monitor.desipramineprochlorperazine and desipramine both increase QTc interval. Use Caution/Monitor.prochlorperazine and desipramine both increase sedation. Use Caution/Monitor.desvenlafaxinedesvenlafaxine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgdeutetrabenazineprochlorperazine and deutetrabenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely. The risk for parkinsonism, neuroleptic malignant syndrome, and akathisia may be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics.deutetrabenazine and prochlorperazine both decrease QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniraminedexchlorpheniramine and prochlorperazine both increase sedation. Use Caution/Monitor.dexfenfluramineprochlorperazine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, dexfenfluramine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.dexmedetomidinedexmedetomidine and prochlorperazine both increase sedation. Use Caution/Monitor.dexmethylphenidateprochlorperazine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, dexmethylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.dextroamphetamineprochlorperazine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, dextroamphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.dextromoramidedextromoramide and prochlorperazine both increase sedation. Use Caution/Monitor.diamorphinediamorphine and prochlorperazine both increase sedation. Use Caution/Monitor.diazepamdiazepam and prochlorperazine both increase sedation. Use Caution/Monitor.dicyclominedicyclomine decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.dicyclomine decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of dicyclomine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.diethylpropionprochlorperazine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, diethylpropion. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.difelikefalindifelikefalin and prochlorperazine both increase sedation. Use Caution/Monitor.difenoxin hcldifenoxin hcl and prochlorperazine both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and prochlorperazine both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and prochlorperazine both increase sedation. Use Caution/Monitor.diphenhydramine decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.diphenhydramine decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases effects of diphenhydramine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.diphenoxylate hcldiphenoxylate hcl and prochlorperazine both increase sedation. Use Caution/Monitor.dipipanonedipipanone and prochlorperazine both increase sedation. Use Caution/Monitor.dobutamineprochlorperazine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, dobutamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.dolasetronprochlorperazine and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.donepezildonepezil and prochlorperazine both decrease QTc interval. Use Caution/Monitor.donepezil transdermaldonepezil transdermal, prochlorperazine. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.dopamineprochlorperazine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, dopamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.dopexamineprochlorperazine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinprochlorperazine and dosulepin both increase sedation. Use Caution/Monitor.doxepinprochlorperazine and doxepin both increase QTc interval. Use Caution/Monitor.prochlorperazine and doxepin both increase sedation. Use Caution/Monitor.doxylaminedoxylamine and prochlorperazine both increase sedation. Use Caution/Monitor.droperidoldroperidol and prochlorperazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.droperidol and prochlorperazine both increase sedation. Use Caution/Monitor.efavirenzefavirenz and prochlorperazine both decrease QTc interval. Use Caution/Monitor.eliglustateliglustat and prochlorperazine both decrease QTc interval. Use Caution/Monitor.encorafenibencorafenib and prochlorperazine both decrease QTc interval. Use Caution/Monitor.entrectinibentrectinib and prochlorperazine both decrease QTc interval. Use Caution/Monitor.ephedrineprochlorperazine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, ephedrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.epinephrineprochlorperazine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine, epinephrine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines.