evidence of fetal risk. B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available. Mechanism of Action Interleukin-1 receptor antagonist (recombinant E. coli-derived product) Blocks activity of IL-1 alpha and beta by competitively inhibiting IL-1 binding to the IL-1 type I receptor IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses Proteolytic maturation and secretion of IL-1 beta has an important role in the systemic inflammation and manifestations of NOMID DIRA is an autosomal recessive monogenic autoinflammatory disease caused by mutations in the IL1RN gene leading to loss of secretion IL-1Ra Absorption Bioavailability: 95% Peak plasma time: 3-7 hr (RA) Peak plasma concentration: 3,628 ng/mL (NOMID) Elimination Half-life: 4-6 hr (RA); 5.7 hr (NOMID) Hemodialysis or CAPD: <2.5% Excretion: urine SC Administration SC administration only Rotate injection site (thigh, abdomen, upper arm, upper buttocks) Each syringe is for single use only; use a new syringe for each dose; discard any unused portion after each dose Review instructions on appropriate use to patient and/or caregiver Do not use beyond expiration date shown on carton Visually inspect solution for particulate matter and discoloration before administration; trace amounts of small, translucent-to-white amorphous particles of protein in the solution may appear Do not use if solution is discolored or cloudy, if foreign particulate matter is present, or number of translucent-to-white amorphous particles in a given syringe appears excessive Storage Refrigerate at 2-8ºC (36-46ºF) Do not freeze or shake Protect from light BRAND FORM. UNIT PRICE PILL IMAGE Kineret subcutaneous- 100 mg/0.67 mL solutionKineret subcutaneous- 100 mg/0.67 mL solutionCopyright © 2010 First DataBank, Inc.Print Patient Educationanakinra subcutaneous ANAKINRA - INJECTION (an-a-KIN-ra) COMMON BRAND NAME(S): Kineret USES: Anakinra is used to treat rheumatoid arthritis. It helps to slow joint damage and reduces the joint pain/swelling so that you can move better. It is also used to treat a certain group of inherited disorders called cryopyrin-associated periodic syndromes (CAPS), including neonatal-onset multisystem inflammatory disease (NOMID). It helps to improve symptoms of NOMID such as fever, rash, joint pain, vomiting, and headache. Anakinra may also be used to treat another condition called Deficiency of Interleukin-1 Receptor Antagonist (DIRA), a condition where your body does not produce the natural protein interleukin-1 receptor antagonist.Anakinra is a man-made form of a natural protein (interleukin-1 receptor antagonist) made by the body. It helps to block the effects of another protein (interleukin-1) which can cause symptoms such as joint pain/swelling/stiffness.The FDA is allowing the emergency use of anakinra to treat coronavirus disease (COVID-19) in hospitalized patients with pneumonia and who also need supplemental oxygen. If anakinra is used to treat coronavirus disease, more information about the drug is available from the patient information sheet provided by your health care professional. HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start using anakinra and each time you get a refill. If you have any questions, consult your doctor or pharmacist.If you are giving the shots yourself, you will be trained by a health care professional on how to properly prepare and inject this product. If any of the information is unclear, consult your health care professional.This medication is injected under the skin (subcutaneously) as directed by your doctor, usually once a day. The dosage is based on your medical condition, weight, and response to treatment.Do not shake this medication. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Let the medication warm to room temperature for 30 minutes before injecting it.Before injecting each dose, clean the injection site with rubbing alcohol. It is important to change the location of the injection site daily to avoid problem areas under the skin. Do not inject this medication in an area that is tender, red, bruised, or hard or which has scars or stretch marks.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.Do not reuse the syringe. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for more details.Tell your doctor if your condition does not improve or if it worsens. SIDE EFFECTS: Redness, bruising, swelling, and pain at the injection site may occur. These skin reactions are usually mild and may last 2 to 4 weeks. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Anakinra has caused very serious infections (such as skin/bone/joint infections, pneumonia). Tell your doctor right away if you develop signs of an infection, including: sore throat that doesn't go away, fever/chills, cough with mucus, spreading redness/swelling/tenderness of the skin, bone pain.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before using anakinra, tell your doctor or pharmacist if you are allergic to it; or to proteins made from a certain bacteria (E. coli); or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/past/returning infections (such as tuberculosis), immune system problems (such as HIV disease), kidney disease, asthma.Anakinra can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.Tell your health care professional that you are using anakinra before having any immunizations/vaccinations. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).Older adults may be at greater risk for infections while using this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: abatacept, TNF blockers (such as adalimumab, certolizumab, etanercept, infliximab). OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. NOTES: Do not share this medication with others.Lab and/or medical tests (such as absolute neutrophil count) should be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details. MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up. STORAGE: Store in the refrigerator away from light. Do not freeze. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Information last revised April 2023. Copyright(c) 2023 First Databank, Inc. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. FormularyPatient DiscountsAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.Create Your List of PlansAdding plans allows you to:View the formulary and any restrictions for each plan.Manage and view all your plans together – even plans in different states.Compare formulary status to other drugs in the same class.Access your plan list on any device – mobile or desktop. The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. View explanations for tiers and restrictions Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. 2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs. 3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs. 4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. 6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. NC NOT COVERED – Drugs that are not covered by the plan. Code Definition PA Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. Plans Select State: Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Puerto Rico Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming Done Non-Medicare Plans Medicare Plans Done CLOSE Additional Offers CLOSE Email to Patient From: To: The recipient will receive more details and instructions to access this offer. By clicking send, you acknowledge that you have permission to email the recipient with this information. 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