Major Depressive Disorder Pending FDA approval for treatment of major depressive disorder (MDD) Postpartum Depression Pending FDA approval for treatment of postpartum depression (PPD) Mechanism of Action Oral neuroactive steroid (NAS) GABA-A receptor positive allosteric modulator (PAM) The GABA system is the major inhibitory signaling pathway of the brain and CNS and contributes to regulating brain function (eg, mood, arousal, behavior, cognition) No images available for this drug. No images available for this drug.A Patient Handout is not currently available for this monograph.Print