cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozideaclidinium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.pimozide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozide increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.pindololpindolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pindolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.pralidoximepralidoxime and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.pirbuterolformoterol and pirbuterol both decrease serum potassium. Use Caution/Monitor.formoterol and pirbuterol both decrease sedation. Use Caution/Monitor.formoterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.piroxicampiroxicam increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazoleformoterol and posaconazole both increase QTc interval. Modify Therapy/Monitor Closely.potassium acid phosphatepotassium acid phosphate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.potassium chloridepotassium chloride increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.potassium citratepotassium citrate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.primidoneprimidone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.procarbazineprocarbazine increases effects of formoterol by pharmacodynamic synergism. Use Caution/Monitor.prochlorperazineaclidinium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.prochlorperazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.prochlorperazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.promethazinepromethazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.promethazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.aclidinium decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.propanthelinepropantheline and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.propranololpropranolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.propranolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.propylhexedrineformoterol and propylhexedrine both decrease sedation. Use Caution/Monitor.formoterol and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.protriptylineprotriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.pseudoephedrineformoterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.pyridostigminepyridostigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.quazepamquazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.quetiapineaclidinium decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.quetiapine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.quetiapine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.quinineformoterol and quinine both increase QTc interval. Use Caution/Monitor.rapacuroniumrapacuronium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.ranolazineformoterol and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.ribociclibribociclib increases toxicity of formoterol by QTc interval. Use Caution/Monitor.rimantadineaclidinium, rimantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Enhanced CNS side effects.risperidonerisperidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.formoterol and risperidone both increase QTc interval. Modify Therapy/Monitor Closely.aclidinium decreases levels of risperidone by pharmacodynamic antagonism. Use Caution/Monitor.risperidone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.rivastigminerivastigmine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.sacubitril/valsartansacubitril/valsartan increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.rocuroniumrocuronium and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.salicylates (non-asa)salicylates (non-asa) increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.salmeterolformoterol and salmeterol both decrease serum potassium. Use Caution/Monitor.formoterol and salmeterol both decrease sedation. Use Caution/Monitor.formoterol and salmeterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.salsalatesalsalate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.scopolaminescopolamine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.scullcapscullcap increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.secobarbitalsecobarbital increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.selpercatinibselpercatinib increases toxicity of formoterol by QTc interval. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidateformoterol and serdexmethylphenidate/dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.shepherd's purseshepherd's purse increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycolformoterol and sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.solifenacinsolifenacin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.solriamfetolformoterol and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.sorafenibsorafenib and formoterol both increase QTc interval. Use Caution/Monitor.sotalolsotalol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.sotalol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.spironolactonespironolactone increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.succinylcholinesuccinylcholine increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.succinylcholine increases and aclidinium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.sufentanilsufentanil increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineaclidinium decreases levels of thioridazine by pharmacodynamic antagonism. Use Caution/Monitor.thioridazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.sulfamethoxazolesulfamethoxazole and formoterol both increase QTc interval. Modify Therapy/Monitor Closely.sulfasalazinesulfasalazine increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.sulindacsulindac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.tapentadoltapentadol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.telavancinformoterol and telavancin both increase QTc interval. Modify Therapy/Monitor Closely.temazepamtemazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.terbutalineformoterol and terbutaline both decrease serum potassium. Use Caution/Monitor.formoterol and terbutaline both decrease sedation. Use Caution/Monitor.formoterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.thioridazinethioridazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thiothixenethiothixene increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thiothixene increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.aclidinium decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.timololtimolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.timolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.tolterodineaclidinium and tolterodine both decrease cholinergic effects/transmission. Use Caution/Monitor.tolfenamic acidtolfenamic acid increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.tolmetintolmetin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.tolvaptantolvaptan increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.topiramatetopiramate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.torsemideformoterol and torsemide both decrease serum potassium. Use Caution/Monitor.tramadoltramadol increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodonetrazodone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.triamterenetriamterene increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.trifluoperazineaclidinium decreases levels of trifluoperazine by pharmacodynamic antagonism. Use Caution/Monitor.trifluoperazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.triazolamtriazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triclofostriclofos increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trifluoperazinetrifluoperazine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trihexyphenidylaclidinium and trihexyphenidyl both decrease cholinergic effects/transmission. Use Caution/Monitor.trimethoprimformoterol and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely.trimipraminetrimipramine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aclidinium and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.triprolidinetriprolidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trospium chlorideaclidinium and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.triptorelintriptorelin increases levels of formoterol by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.tropisetronformoterol and tropisetron both increase QTc interval. Modify Therapy/Monitor Closely.umeclidinium bromideumeclidinium bromide and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor. If possible, avoid coadministration of additional anticholinergic agentsvecuroniumaclidinium and vecuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.venlafaxineformoterol and venlafaxine both increase QTc interval. Modify Therapy/Monitor Closely.voriconazoleformoterol and voriconazole both increase QTc interval. Modify Therapy/Monitor Closely.xylometazolineformoterol and xylometazoline both decrease sedation. Use Caution/Monitor.formoterol and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.yohimbineformoterol and yohimbine both decrease sedation. Use Caution/Monitor.formoterol and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.ziconotideziconotide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziprasidoneaclidinium decreases levels of ziprasidone by pharmacodynamic antagonism. Use Caution/Monitor.ziprasidone increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.ziprasidone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.zotepineaclidinium decreases levels of zotepine by pharmacodynamic antagonism. Use Caution/Monitor.Minor (20)bendroflumethiazideformoterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.bumetanideformoterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chloroquinechloroquine increases toxicity of formoterol by QTc interval. Minor/Significance Unknown.chlorothiazideformoterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.chlorthalidoneformoterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.cyclopenthiazideformoterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.dimenhydrinatedimenhydrinate increases toxicity of aclidinium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.donepezildonepezil decreases effects of aclidinium by pharmacodynamic antagonism. Minor/Significance Unknown.ethacrynic acidformoterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.eucalyptuseucalyptus increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.furosemideformoterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.galantaminegalantamine decreases effects of aclidinium by pharmacodynamic antagonism. Minor/Significance Unknown.green teagreen tea increases effects of formoterol by pharmacodynamic synergism. Minor/Significance Unknown. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.hydrochlorothiazideformoterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.indapamideformoterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.methyclothiazideformoterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.metolazoneformoterol, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.noni juicenoni juice increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.rimantadinerimantadine increases effects of aclidinium by pharmacodynamic synergism. Minor/Significance Unknown.sagesage increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.abobotulinumtoxinAMonitor Closely (1)abobotulinumtoxinA increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .acebutololMonitor Closely (2)acebutolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor. acebutolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.aceclofenacMonitor Closely (1)aceclofenac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinMonitor Closely (1)acemetacin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.adagrasibSerious - Use Alternative (1)adagrasib, formoterol. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.albuterolMonitor Closely (3)albuterol and formoterol both decrease serum potassium. Use Caution/Monitor. albuterol and formoterol both decrease sedation. Use Caution/Monitor. albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfuzosinMonitor Closely (2)formoterol and alfuzosin both increase QTc interval. Use Caution/Monitor. alfuzosin and formoterol both increase QTc interval. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amantadineMonitor Closely (1)aclidinium, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.amilorideMonitor Closely (1)amiloride increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.amiodaroneMonitor Closely (1)amiodarone and formoterol both increase QTc interval. Use Caution/Monitor.amisulprideSerious - Use Alternative (1)amisulpride and formoterol both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineMonitor Closely (2)aclidinium and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. amitriptyline increases and formoterol decreases sedation. Effect