sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difelikefalinMonitor Closely (1)difelikefalin and chloral hydrate both increase sedation. Use Caution/Monitor.difenoxin hclMonitor Closely (1)chloral hydrate and difenoxin hcl both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate and chloral hydrate both increase sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)diphenhydramine and chloral hydrate both increase sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)chloral hydrate and diphenoxylate hcl both increase sedation. Use Caution/Monitor.dipipanoneMonitor Closely (1)chloral hydrate and dipipanone both increase sedation. Use Caution/Monitor.dobutamineMonitor Closely (1)chloral hydrate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopamineMonitor Closely (1)chloral hydrate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineMonitor Closely (1)chloral hydrate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinMonitor Closely (1)chloral hydrate and dosulepin both increase sedation. Use Caution/Monitor.doxepinMonitor Closely (1)chloral hydrate and doxepin both increase sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)chloral hydrate and doxylamine both increase sedation. Use Caution/Monitor.droperidolMonitor Closely (1)chloral hydrate and droperidol both increase sedation. Use Caution/Monitor.ephedrineMonitor Closely (1)chloral hydrate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineMonitor Closely (1)chloral hydrate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicMonitor Closely (1)chloral hydrate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam and chloral hydrate both increase sedation. Use Caution/Monitor.ethanolMonitor Closely (1)chloral hydrate and ethanol both increase sedation. Use Caution/Monitor.etomidateMonitor Closely (1)etomidate and chloral hydrate both increase sedation. Use Caution/Monitor.eucalyptusMinor (1)chloral hydrate and eucalyptus both increase sedation. Minor/Significance Unknown.fenfluramineMonitor Closely (1)chloral hydrate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fentanylSerious - Use Alternative (1)fentanyl, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl intranasalSerious - Use Alternative (1)fentanyl intranasal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transdermalSerious - Use Alternative (1)fentanyl transdermal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.fentanyl transmucosalSerious - Use Alternative (1)fentanyl transmucosal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.flibanserinMonitor Closely (1)chloral hydrate and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fluphenazineMonitor Closely (1)chloral hydrate and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam and chloral hydrate both increase sedation. Use Caution/Monitor.formoterolMonitor Closely (1)chloral hydrate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.gabapentinMonitor Closely (1)gabapentin, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (1)gabapentin enacarbil, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)chloral hydrate and ganaxolone both increase sedation. Use Caution/Monitor.gotu kolaMonitor Closely (1)gotu kola increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.haloperidolMonitor Closely (1)chloral hydrate and haloperidol both increase sedation. Use Caution/Monitor.hawthornMonitor Closely (1)hawthorn increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.hopsMonitor Closely (1)hops increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.hydrocodoneSerious - Use Alternative (1)hydrocodone, chloral hydrate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.hydromorphoneMonitor Closely (1)chloral hydrate and hydromorphone both increase sedation. Use Caution/Monitor.hydroxyzineMonitor Closely (1)hydroxyzine and chloral hydrate both increase sedation. Use Caution/Monitor.iloperidoneMonitor Closely (1)chloral hydrate and iloperidone both increase sedation. Use Caution/Monitor.imipramineMonitor Closely (1)chloral hydrate and imipramine both increase sedation. Use Caution/Monitor.isoproterenolMonitor Closely (1)chloral hydrate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.kavaMonitor Closely (1)kava increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.ketamineMonitor Closely (1)ketamine and chloral hydrate both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicMonitor Closely (1)chloral hydrate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.lasmiditanMonitor Closely (1)lasmiditan, chloral hydrate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.lemborexantSerious - Use Alternative (1)lemborexant, chloral hydrate. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.levalbuterolMonitor Closely (1)chloral hydrate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanolMonitor Closely (1)chloral hydrate and levorphanol both increase sedation. Use Caution/Monitor.lisdexamfetamineMonitor Closely (1)chloral hydrate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepramineMonitor Closely (1)chloral hydrate and lofepramine both increase sedation. Use Caution/Monitor.lofexidineMonitor Closely (1)chloral hydrate and lofexidine both increase sedation. Use Caution/Monitor.loprazolamMonitor Closely (1)loprazolam and chloral hydrate both increase sedation. Use Caution/Monitor.lorazepamMonitor Closely (1)lorazepam and chloral hydrate both increase sedation. Use Caution/Monitor.lormetazepamMonitor Closely (1)lormetazepam and chloral hydrate both increase sedation. Use Caution/Monitor.loxapineMonitor Closely (1)chloral hydrate and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledMonitor Closely (1)chloral hydrate and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidoneMonitor Closely (1)lurasidone, chloral hydrate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilineMonitor Closely (1)chloral hydrate and maprotiline both increase sedation. Use Caution/Monitor.marijuanaMonitor Closely (1)chloral hydrate and marijuana both increase sedation. Use Caution/Monitor.mefloquineSerious - Use Alternative (1)mefloquine increases toxicity of chloral hydrate by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.melatoninMonitor Closely (1)chloral hydrate and melatonin both increase sedation. Use Caution/Monitor.meperidineMonitor Closely (1)chloral hydrate and meperidine both increase sedation. Use Caution/Monitor.meprobamateMonitor Closely (1)chloral hydrate and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolMonitor Closely (1)chloral hydrate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneMonitor Closely (1)chloral hydrate and metaxalone both increase sedation. Use Caution/Monitor.methadoneMonitor Closely (1)chloral hydrate and methadone both increase sedation. Use Caution/Monitor.methamphetamineMonitor Closely (1)chloral hydrate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolMonitor Closely (1)chloral hydrate and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineMonitor Closely (1)chloral hydrate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metoclopramide intranasalSerious - Use Alternative (1)chloral hydrate, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.midazolamMonitor Closely (1)midazolam and chloral hydrate both increase sedation. Use Caution/Monitor.midazolam intranasalMonitor Closely (1)midazolam intranasal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineMonitor Closely (1)chloral hydrate increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineMonitor Closely (1)chloral hydrate and mirtazapine both increase sedation. Use Caution/Monitor.modafinilMonitor Closely (1)chloral hydrate increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineMonitor Closely (1)chloral hydrate and morphine both increase sedation. Use Caution/Monitor.motherwortMonitor Closely (1)chloral hydrate and motherwort both increase sedation. Use Caution/Monitor.moxonidineMonitor Closely (1)chloral hydrate and moxonidine both increase sedation. Use Caution/Monitor.nabiloneMonitor Closely (1)chloral hydrate and nabilone both increase sedation. Use Caution/Monitor.nalbuphineMonitor Closely (1)chloral hydrate and nalbuphine both increase sedation. Use Caution/Monitor.nettleMinor (1)nettle increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.norepinephrineMonitor Closely (1)chloral hydrate increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineMonitor Closely (1)chloral hydrate and nortriptyline both increase sedation. Use Caution/Monitor.olanzapineMonitor Closely (1)chloral hydrate and olanzapine both increase sedation. Use Caution/Monitor.oliceridineMonitor Closely (1)oliceridine, chloral hydrate. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.olopatadine intranasalSerious - Use Alternative (1)chloral hydrate and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. opium tinctureMonitor Closely (1)chloral hydrate and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineMonitor Closely (1)chloral hydrate and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamMonitor Closely (1)oxazepam and chloral hydrate both increase sedation. Use Caution/Monitor.oxycodoneMonitor Closely (1)chloral hydrate and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneMonitor Closely (1)chloral hydrate and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneMonitor Closely (1)chloral hydrate and paliperidone both increase sedation. Use Caution/Monitor.papaveretumMonitor Closely (1)chloral hydrate and papaveretum both increase sedation. Use Caution/Monitor.papaverineMonitor Closely (1)chloral hydrate and papaverine both increase sedation. Use Caution/Monitor.passion flowerMonitor Closely (1)passion flower increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.pentazocineMonitor Closely (1)chloral hydrate and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital and chloral hydrate both increase sedation. Use Caution/Monitor.perphenazineMonitor Closely (1)chloral hydrate and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineMonitor Closely (1)chloral hydrate increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalMonitor Closely (1)phenobarbital and chloral hydrate both increase sedation. Use Caution/Monitor.phentermineMonitor Closely (1)chloral hydrate increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineMonitor Closely (1)chloral hydrate increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POMonitor Closely (1)chloral hydrate increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineMonitor Closely (1)chloral hydrate and pholcodine both increase sedation. Use Caution/Monitor.pimozideMonitor Closely (1)chloral hydrate and pimozide both increase sedation. Use Caution/Monitor.pirbuterolMonitor Closely (1)chloral hydrate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinMonitor Closely (1)pregabalin, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneMonitor Closely (1)primidone and chloral hydrate both increase sedation. Use Caution/Monitor.prochlorperazineMonitor Closely (1)chloral hydrate and prochlorperazine both increase sedation. Use Caution/Monitor.promethazineMonitor Closely (1)promethazine and chloral hydrate both increase sedation. Use Caution/Monitor.propofolMonitor Closely (1)propofol and chloral hydrate both increase sedation. Use Caution/Monitor.propylhexedrineMonitor Closely (1)chloral hydrate increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineMonitor Closely (1)chloral hydrate and protriptyline both increase sedation. Use Caution/Monitor.quazepamMonitor Closely (1)quazepam and chloral hydrate both increase sedation. Use Caution/Monitor.quetiapineMonitor Closely (1)chloral hydrate and quetiapine both increase sedation. Use Caution/Monitor.ramelteonMonitor Closely (1)chloral hydrate and ramelteon both increase sedation. Use Caution/Monitor.remimazolamMonitor Closely (1)remimazolam, chloral hydrate. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may