both increase sedation. Use Caution/Monitor.lisdexamfetaminechloral hydrate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofepraminechloral hydrate and lofepramine both increase sedation. Use Caution/Monitor.lofexidinechloral hydrate and lofexidine both increase sedation. Use Caution/Monitor.loprazolamloprazolam and chloral hydrate both increase sedation. Use Caution/Monitor.lorazepamlorazepam and chloral hydrate both increase sedation. Use Caution/Monitor.lormetazepamlormetazepam and chloral hydrate both increase sedation. Use Caution/Monitor.loxapinechloral hydrate and loxapine both increase sedation. Use Caution/Monitor.loxapine inhaledchloral hydrate and loxapine inhaled both increase sedation. Use Caution/Monitor.lurasidonelurasidone, chloral hydrate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.maprotilinechloral hydrate and maprotiline both increase sedation. Use Caution/Monitor.marijuanachloral hydrate and marijuana both increase sedation. Use Caution/Monitor.melatoninchloral hydrate and melatonin both increase sedation. Use Caution/Monitor.meperidinechloral hydrate and meperidine both increase sedation. Use Caution/Monitor.meprobamatechloral hydrate and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolchloral hydrate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonechloral hydrate and metaxalone both increase sedation. Use Caution/Monitor.methadonechloral hydrate and methadone both increase sedation. Use Caution/Monitor.methamphetaminechloral hydrate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolchloral hydrate and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminechloral hydrate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and chloral hydrate both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinechloral hydrate increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapinechloral hydrate and mirtazapine both increase sedation. Use Caution/Monitor.modafinilchloral hydrate increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinechloral hydrate and morphine both increase sedation. Use Caution/Monitor.motherwortchloral hydrate and motherwort both increase sedation. Use Caution/Monitor.moxonidinechloral hydrate and moxonidine both increase sedation. Use Caution/Monitor.nabilonechloral hydrate and nabilone both increase sedation. Use Caution/Monitor.nalbuphinechloral hydrate and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrinechloral hydrate increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinechloral hydrate and nortriptyline both increase sedation. Use Caution/Monitor.olanzapinechloral hydrate and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, chloral hydrate. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tincturechloral hydrate and opium tincture both increase sedation. Use Caution/Monitor.orphenadrinechloral hydrate and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamoxazepam and chloral hydrate both increase sedation. Use Caution/Monitor.oxycodonechloral hydrate and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonechloral hydrate and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonechloral hydrate and paliperidone both increase sedation. Use Caution/Monitor.papaveretumchloral hydrate and papaveretum both increase sedation. Use Caution/Monitor.papaverinechloral hydrate and papaverine both increase sedation. Use Caution/Monitor.passion flowerpassion flower increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.pentazocinechloral hydrate and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and chloral hydrate both increase sedation. Use Caution/Monitor.perphenazinechloral hydrate and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazinechloral hydrate increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and chloral hydrate both increase sedation. Use Caution/Monitor.phenterminechloral hydrate increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinechloral hydrate increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POchloral hydrate increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinechloral hydrate and pholcodine both increase sedation. Use Caution/Monitor.pimozidechloral hydrate and pimozide both increase sedation. Use Caution/Monitor.pirbuterolchloral hydrate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinpregabalin, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and chloral hydrate both increase sedation. Use Caution/Monitor.prochlorperazinechloral hydrate and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and chloral hydrate both increase sedation. Use Caution/Monitor.propofolpropofol and chloral hydrate both increase sedation. Use Caution/Monitor.propylhexedrinechloral hydrate increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinechloral hydrate and protriptyline both increase sedation. Use Caution/Monitor.quazepamquazepam and chloral hydrate both increase sedation. Use Caution/Monitor.quetiapinechloral hydrate and quetiapine both increase sedation. Use Caution/Monitor.ramelteonchloral hydrate and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, chloral hydrate. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.risperidonechloral hydrate and risperidone both increase sedation. Use Caution/Monitor.salmeterolchloral hydrate increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapchloral hydrate and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and chloral hydrate both increase sedation. Use Caution/Monitor.sevofluranesevoflurane and chloral hydrate both increase sedation. Use Caution/Monitor.shepherd's pursechloral hydrate and shepherd's purse both increase sedation. Use Caution/Monitor.sufentanilchloral hydrate and sufentanil both increase sedation. Use Caution/Monitor.tapentadolchloral hydrate and tapentadol both increase sedation. Use Caution/Monitor.temazepamtemazepam and chloral hydrate both increase sedation. Use Caution/Monitor.terbutalinechloral hydrate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazinechloral hydrate and thioridazine both increase sedation. Use Caution/Monitor.thiothixenechloral hydrate and thiothixene both increase sedation. Use Caution/Monitor.topiramatechloral hydrate and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadolchloral hydrate and tramadol both increase sedation. Use Caution/Monitor.trazodonechloral hydrate and trazodone both increase sedation. Use Caution/Monitor.triazolamtriazolam and chloral hydrate both increase sedation. Use Caution/Monitor.triclofoschloral hydrate and triclofos both increase sedation. Use Caution/Monitor.trifluoperazinechloral hydrate and trifluoperazine both increase sedation. Use Caution/Monitor.trimipraminechloral hydrate and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and chloral hydrate both increase sedation. Use Caution/Monitor.valerianvalerian increases effects of chloral hydrate by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.warfarinchloral hydrate increases effects of warfarin by unspecified interaction mechanism. Use Caution/Monitor.xylometazolinechloral hydrate increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinechloral hydrate increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidechloral hydrate and ziconotide both increase sedation. Use Caution/Monitor.ziprasidonechloral hydrate and ziprasidone both increase sedation. Use Caution/Monitor.zotepinechloral hydrate and zotepine both increase sedation. Use Caution/Monitor.Minor (6)ashwagandhaashwagandha increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.brimonidinebrimonidine increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.eucalyptuschloral hydrate and eucalyptus both increase sedation. Minor/Significance Unknown.nettlenettle increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.sagechloral hydrate and sage both increase sedation. Minor/Significance Unknown.Siberian ginsengSiberian ginseng increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.albuterolMonitor Closely (1)chloral hydrate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)chloral hydrate and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and chloral hydrate both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)chloral hydrate and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and chloral hydrate both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)chloral hydrate and amoxapine both increase sedation. Use Caution/Monitor.apomorphineMonitor Closely (1)chloral hydrate and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)chloral hydrate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)chloral hydrate and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)chloral hydrate increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ashwagandhaMinor (1)ashwagandha increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.azelastineMonitor Closely (1)azelastine and chloral hydrate both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)chloral hydrate and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)chloral hydrate and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)chloral hydrate and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (1)benzhydrocodone/acetaminophen, chloral hydrate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzphetamineMonitor Closely (1)chloral hydrate increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, chloral hydrate. Either increases toxicity of the other by sedation. Use Caution/Monitor.brimonidineMinor (1)brimonidine increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brompheniramineMonitor Closely (1)brompheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)chloral hydrate and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)chloral hydrate and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionMonitor Closely (1)chloral hydrate increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.butabarbitalMonitor Closely (1)butabarbital and chloral hydrate both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and chloral hydrate both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)chloral hydrate and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)chloral hydrate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesContraindicated (1)chloral hydrate, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.carbinoxamineMonitor Closely (1)carbinoxamine and chloral hydrate both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)chloral hydrate and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, chloral hydrate. Either increases effects of the other by sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and chloral hydrate both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)chloral hydrate and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)chloral hydrate and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and chloral hydrate both increase sedation. Use Caution/Monitor.clemastineMonitor Closely (1)clemastine and chloral hydrate both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)chloral hydrate, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)chloral hydrate and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and chloral hydrate both increase sedation. Use Caution/Monitor.clorazepateMonitor Closely (1)clorazepate and chloral hydrate both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)chloral hydrate and clozapine both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)chloral hydrate and codeine both increase sedation. Use Caution/Monitor.cyclizineMonitor Closely (1)cyclizine and chloral hydrate both increase sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)chloral hydrate and cyclobenzaprine both increase sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)cyproheptadine and chloral hydrate both increase sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)chloral hydrate and dantrolene both increase sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)chloral hydrate and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desipramineMonitor Closely (1)chloral hydrate and desipramine both increase sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)chloral hydrate and deutetrabenazine both increase sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.dexfenfluramineMonitor Closely (1)chloral hydrate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)chloral hydrate and dexmedetomidine both increase sedation. Use Caution/Monitor.dexmethylphenidateMonitor Closely (1)chloral hydrate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetamineMonitor Closely (1)chloral hydrate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramideMonitor Closely (1)chloral hydrate and dextromoramide both increase sedation. Use Caution/Monitor.diamorphineMonitor Closely (1)chloral hydrate and diamorphine both increase sedation. Use Caution/Monitor.diazepamMonitor Closely (1)diazepam and chloral hydrate both increase sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, chloral hydrate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionMonitor Closely (1)chloral hydrate increases and diethylpropion decreases