may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.sufentanil SLsufentanil SL, fluphenazine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.tetrabenazinetetrabenazine and fluphenazine both increase QTc interval. Avoid or Use Alternate Drug.thioridazinefluphenazine and thioridazine both increase QTc interval. Avoid or Use Alternate Drug.trazodonefluphenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.tretinoinfluphenazine, tretinoin. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased phototoxicity.tretinoin topicalfluphenazine, tretinoin topical. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased phototoxicity.trifluoperazinefluphenazine and trifluoperazine both increase QTc interval. Avoid or Use Alternate Drug.trimipraminefluphenazine and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.umeclidinium bromide/vilanterol inhaledfluphenazine increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.venlafaxinefluphenazine and venlafaxine both increase QTc interval. Avoid or Use Alternate Drug.vilanterol/fluticasone furoate inhaledfluphenazine increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.yohimbeyohimbe decreases effects of fluphenazine by pharmacodynamic antagonism. Contraindicated.ziprasidonefluphenazine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (354)abirateroneabiraterone increases levels of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.abobotulinumtoxinAabobotulinumtoxinA increases effects of fluphenazine by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects.aclidiniumaclidinium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of aclidinium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.acrivastineacrivastine and fluphenazine both increase sedation. Use Caution/Monitor.albiglutidefluphenazine, albiglutide. Other (see comment). Use Caution/Monitor. Comment: Phenothiazines may increase or decrease glucose levels, monitor therapy closely when these agents are concurrently administered.albuterolfluphenazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and fluphenazine both increase QTc interval. Use Caution/Monitor.alfentanilalfentanil and fluphenazine both increase sedation. Use Caution/Monitor.alfuzosinfluphenazine and alfuzosin both increase QTc interval. Use Caution/Monitor.alfuzosin and fluphenazine both increase QTc interval. Use Caution/Monitor.almotriptanalmotriptan, fluphenazine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).alprazolamalprazolam and fluphenazine both increase sedation. Use Caution/Monitor.amifampridinefluphenazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.amisulpridefluphenazine and amisulpride both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.amitriptylinefluphenazine and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalamobarbital and fluphenazine both increase sedation. Use Caution/Monitor.amoxapinefluphenazine and amoxapine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely.fluphenazine and amoxapine both increase sedation. Use Caution/Monitor.anagrelideanagrelide and fluphenazine both increase QTc interval. Use Caution/Monitor.anticholinergic/sedative combosanticholinergic/sedative combos decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.anticholinergic/sedative combos decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of anticholinergic/sedative combos by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.apomorphinefluphenazine and apomorphine both increase sedation. Use Caution/Monitor.arformoterolfluphenazine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and fluphenazine both increase QTc interval. Use Caution/Monitor.aripiprazolearipiprazole and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.aripiprazole and fluphenazine both increase sedation. Use Caution/Monitor.armodafinilfluphenazine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.artemetherartemether and fluphenazine both increase QTc interval. Use Caution/Monitor.artemether/lumefantrineartemether/lumefantrine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.asenapineasenapine and fluphenazine both increase QTc interval. Use Caution/Monitor.asenapine and fluphenazine both increase sedation. Use Caution/Monitor.asenapine transdermalasenapine transdermal and fluphenazine both increase QTc interval. Use Caution/Monitor.asenapine transdermal and fluphenazine both increase sedation. Use Caution/Monitor.atomoxetineatomoxetine and fluphenazine both increase QTc interval. Use Caution/Monitor.atracuriumatracurium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atracurium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of atracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropineatropine decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of atropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IMfluphenazine increases effects of atropine IV/IM by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.atropine IV/IM decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.atropine IV/IM decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.avapritinibavapritinib and fluphenazine both increase sedation. Use Caution/Monitor.azelastineazelastine and fluphenazine both increase sedation. Use Caution/Monitor.azithromycinfluphenazine and azithromycin both increase QTc interval. Use Caution/Monitor.baclofenbaclofen and fluphenazine both increase sedation. Use Caution/Monitor.bedaquilinefluphenazine and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closelybelladonna alkaloidsbelladonna alkaloids decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna alkaloids decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of belladonna alkaloids by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.belladonna and opiumbelladonna and opium and fluphenazine both increase sedation. Use Caution/Monitor.belladonna and opium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.belladonna and opium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of belladonna and opium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.benperidolbenperidol and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.benperidol and fluphenazine both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenbenzhydrocodone/acetaminophen and fluphenazine both increase sedation. Use Caution/Monitor.benzphetaminefluphenazine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluphenazine, benzphetamine. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.benztropinefluphenazine increases effects of benztropine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use. .brexanolonebrexanolone, fluphenazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazolebrexpiprazole and fluphenazine both increase sedation. Use Caution/Monitor.brimonidinebrimonidine and fluphenazine both increase sedation. Use Caution/Monitor.brivaracetambrivaracetam and fluphenazine both increase sedation. Use Caution/Monitor.brompheniraminebrompheniramine and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine and fluphenazine both increase QTc interval. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine buccal and fluphenazine both increase QTc interval. Use Caution/Monitor.buprenorphine subdermal implantbuprenorphine subdermal implant and fluphenazine both increase QTc interval. Use Caution/Monitor.buprenorphine subdermal implant and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine transdermalbuprenorphine transdermal and fluphenazine both increase QTc interval. Use Caution/Monitor.buprenorphine transdermal and fluphenazine both increase sedation. Use Caution/Monitor.buprenorphine, long-acting injectionfluphenazine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.buprenorphine, long-acting injection and fluphenazine both increase QTc interval. Use Caution/Monitor.buprenorphine, long-acting injection and fluphenazine both increase sedation. Use Caution/Monitor.bupropionbupropion will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.butabarbitalbutabarbital and fluphenazine both increase sedation. Use Caution/Monitor.butalbitalbutalbital and fluphenazine both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and fluphenazine both increase sedation. Use Caution/Monitor.caffeinefluphenazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and fluphenazine both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and fluphenazine both increase sedation. Use Caution/Monitor.ceritinibceritinib and fluphenazine both increase QTc interval. Use Caution/Monitor.chloral hydratechloral hydrate and fluphenazine both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and fluphenazine both increase sedation. Use Caution/Monitor.chlorpheniraminechlorpheniramine and fluphenazine both increase sedation. Use Caution/Monitor.chlorpromazinechlorpromazine and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.chlorpromazine and fluphenazine both increase sedation. Use Caution/Monitor.chlorzoxazonechlorzoxazone and fluphenazine both increase sedation. Use Caution/Monitor.cigarette smokingcigarette smoking decreases levels of fluphenazine by increasing metabolism. Use Caution/Monitor. Interaction mainly seen w/chlorpromazine & thioridazine, but may occur w/other phenothiazines.cinnarizinecinnarizine and fluphenazine both increase sedation. Use Caution/Monitor.cisatracuriumcisatracurium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.cisatracurium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of cisatracurium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.citalopramcitalopram and fluphenazine both increase QTc interval. Use Caution/Monitor.clemastineclemastine and fluphenazine both increase sedation. Use Caution/Monitor.clobazamclobazam will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. fluphenazine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipraminefluphenazine and clomipramine both increase sedation. Use Caution/Monitor.clonazepamclonazepam and fluphenazine both increase sedation. Use Caution/Monitor.clonidineclonidine, fluphenazine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Additive hypotensive effects; potential delirium.clorazepateclorazepate and fluphenazine both increase sedation. Use Caution/Monitor.clozapineclozapine and fluphenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.clozapine and fluphenazine both increase sedation. Use Caution/Monitor.clozapine and fluphenazine both increase QTc interval. Use Caution/Monitor.codeinecodeine and fluphenazine both increase sedation. Use Caution/Monitor.crizotinibcrizotinib and fluphenazine both increase QTc interval. Use Caution/Monitor.cyclizinecyclizine and fluphenazine both increase sedation. Use Caution/Monitor.cyclizine decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.cyclizine decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cyclobenzaprinecyclobenzaprine and fluphenazine both increase sedation. Use Caution/Monitor.cyclobenzaprine decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.cyclobenzaprine decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of cyclobenzaprine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.cyproheptadinecyproheptadine and fluphenazine both increase sedation. Use Caution/Monitor.dantrolenedantrolene and fluphenazine both increase sedation. Use Caution/Monitor.daridorexantfluphenazine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. darifenacindarifenacin decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.darifenacin decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.fluphenazine increases effects of darifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.dasatinibfluphenazine and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.desfluranedesflurane and fluphenazine both increase sedation. Use Caution/Monitor.desflurane and fluphenazine both increase QTc interval. Use Caution/Monitor.desipraminefluphenazine and desipramine both increase sedation. Use Caution/Monitor.desvenlafaxinedesvenlafaxine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgdeutetrabenazinefluphenazine and deutetrabenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely. The risk for parkinsonism, neuroleptic malignant syndrome, and akathisia may be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics.fluphenazine and deutetrabenazine both increase sedation. Use Caution/Monitor.deutetrabenazine and fluphenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval