sedation. Use Caution/Monitor.chlordiazepoxide and difenoxin hcl both increase sedation. Use Caution/Monitor.dihydroergotamineamitriptyline and dihydroergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.dimenhydrinatedimenhydrinate and chlordiazepoxide both increase sedation. Use Caution/Monitor.dihydroergotamine intranasalamitriptyline and dihydroergotamine intranasal both increase serotonin levels. Modify Therapy/Monitor Closely.diltiazemdiltiazem will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Concomitant use with amitriptyline may alter blood pressure control.dimenhydrinatedimenhydrinate and amitriptyline both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and chlordiazepoxide both increase sedation. Use Caution/Monitor.diphenhydramine and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.diphenhydramine and amitriptyline both increase sedation. Use Caution/Monitor.diphenoxylate hclchlordiazepoxide and diphenoxylate hcl both increase sedation. Use Caution/Monitor.diphenoxylate hcl and amitriptyline both increase sedation. Use Caution/Monitor.dipipanonechlordiazepoxide and dipipanone both increase sedation. Use Caution/Monitor.dipipanone and amitriptyline both increase sedation. Use Caution/Monitor.dobutaminechlordiazepoxide increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dofetilidedofetilide increases toxicity of amitriptyline by QTc interval. Use Caution/Monitor.dopaminechlordiazepoxide increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dolasetronamitriptyline and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.donepezildonepezil increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.donepezil and amitriptyline both increase QTc interval. Use Caution/Monitor.dopamineamitriptyline increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexamineamitriptyline increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dosulepinamitriptyline and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.chlordiazepoxide and dosulepin both increase sedation. Use Caution/Monitor.amitriptyline and dosulepin both increase sedation. Use Caution/Monitor.doxepinchlordiazepoxide and doxepin both increase sedation. Use Caution/Monitor.amitriptyline and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.amitriptyline and doxepin both increase sedation. Use Caution/Monitor.doxylaminedoxylamine and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and doxylamine both increase sedation. Use Caution/Monitor.droperidolchlordiazepoxide and droperidol both increase sedation. Use Caution/Monitor.droperidol and amitriptyline both increase sedation. Use Caution/Monitor.duvelisibduvelisib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. will increase the level or effect ofechothiophate iodideechothiophate iodide increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.efavirenzefavirenz and amitriptyline both increase QTc interval. Use Caution/Monitor.efavirenz will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.efavirenz will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.efavirenz will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.elagolixelagolix will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.elagolix will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.eletriptaneletriptan and amitriptyline both increase serotonin levels. Modify Therapy/Monitor Closely.eliglustateliglustat increases levels of chlordiazepoxide by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.eliglustateliglustat increases levels of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the concomitant drug and titrate to clinical effect.eliglustat increases levels of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the P-gp substrate and titrate to clinical effect.eliglustat and amitriptyline both increase QTc interval. Use Caution/Monitor.elvitegravir/cobicistat/emtricitabine/tenofovir DFelvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; consider benzodiazepine dose reduction.encorafenibencorafenib, chlordiazepoxide. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.entrectinibentrectinib and amitriptyline both increase QTc interval. Use Caution/Monitor.ephedrineamitriptyline increases effects of ephedrine by unknown mechanism. Use Caution/Monitor.amitriptyline increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxide increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrineamitriptyline increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.chlordiazepoxide increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine inhaledamitriptyline and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system.epinephrine racemicchlordiazepoxide increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemicamitriptyline increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor.ergotamineamitriptyline and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.eribulineribulin and amitriptyline both increase QTc interval. Use Caution/Monitor.esketamine intranasalesketamine intranasal, amitriptyline. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.esketamine intranasal, chlordiazepoxide. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.eslicarbazepine acetateeslicarbazepine acetate will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.estazolamchlordiazepoxide and estazolam both increase sedation. Use Caution/Monitor.esomeprazoleesomeprazole will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.estazolamestazolam and amitriptyline both increase sedation. Use Caution/Monitor.ethanolamitriptyline and ethanol both increase sedation. Use Caution/Monitor.chlordiazepoxide and ethanol both increase sedation. Use Caution/Monitor.etomidateetomidate and chlordiazepoxide both increase sedation. Use Caution/Monitor.etomidate and amitriptyline both increase sedation. Use Caution/Monitor.etravirineetravirine will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.etravirine will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ezogabineezogabine, amitriptyline. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.fedratinibfedratinib will increase the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.fedratinibfedratinib will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary.felbamatefelbamate will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.felodipinefelodipine will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.fenfluramineamitriptyline increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptyline and fenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.chlordiazepoxide increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fenfluramine, amitriptyline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome.fesoterodinefesoterodine and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.flibanserinchlordiazepoxide and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.fingolimodfingolimod and amitriptyline both increase QTc interval. Use Caution/Monitor.flavoxateflavoxate and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.flecainideamitriptyline and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.fluconazolefluconazole will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.fluconazole will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fluoxetineamitriptyline and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.fluphenazinefluphenazine and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and fluphenazine both increase sedation. Use Caution/Monitor.flurazepamchlordiazepoxide and flurazepam both increase sedation. Use Caution/Monitor.flurazepam and amitriptyline both increase sedation. Use Caution/Monitor.fluvoxaminefluvoxamine and amitriptyline both increase QTc interval. Modify Therapy/Monitor Closely.formoterolchlordiazepoxide increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.formoterolamitriptyline increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fosamprenavirfosamprenavir will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fosamprenavir increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Potential for increased toxicity. Use alternatives if available. Consider lowering benzodiazepine dose.fosaprepitantfosaprepitant will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fosphenytoinfosphenytoin will decrease the level or effect of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.foscarnetamitriptyline and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.fosphenytoinfosphenytoin will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.fosphenytoin will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.fostemsaviramitriptyline and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. frovatriptanfrovatriptan and amitriptyline both increase serotonin levels. Modify Therapy/Monitor Closely.gabapentingabapentin, amitriptyline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilgabapentin enacarbil, chlordiazepoxide. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbil, amitriptyline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.galantaminegalantamine increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.ganaxolonechlordiazepoxide and ganaxolone both increase sedation. Use Caution/Monitor.ganaxoloneamitriptyline and ganaxolone both increase sedation. Use Caution/Monitor.gemifloxacingemifloxacin and amitriptyline both increase QTc interval. Use Caution/Monitor.gilteritinibgilteritinib and amitriptyline both increase QTc interval. Use Caution/Monitor.glecaprevir/pibrentasvirglecaprevir/pibrentasvir will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely.glycopyrrolateglycopyrrolate and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.amitriptyline increases levels of glycopyrrolate by unknown mechanism. Use Caution/Monitor.glycopyrrolate inhaledglycopyrrolate inhaled and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.amitriptyline increases levels of glycopyrrolate inhaled by unknown mechanism. Use Caution/Monitor.glycopyrronium tosylate topicalglycopyrronium tosylate topical, amitriptyline. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.grapefruitgrapefruit will increase the level or effect of amitriptyline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.haloperidolhaloperidol and amitriptyline both increase sedation. Use Caution/Monitor.chlordiazepoxide and haloperidol both increase sedation. Use Caution/Monitor.henbanehenbane and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.hydromorphonechlordiazepoxide and hydromorphone both increase sedation. Use Caution/Monitor.homatropinehomatropine and amitriptyline both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely.huperzine Ahuperzine A increases and amitriptyline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydrocodonehydrocodone, amitriptyline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.hydromorphonehydromorphone and amitriptyline both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and chlordiazepoxide both increase sedation. Use Caution/Monitor.hydroxyzine and amitriptyline both increase sedation. Use Caution/Monitor.hydroxyzine and amitriptyline both increase QTc interval. Use Caution/Monitor.hyoscyaminehyoscyamine and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.iloperidonechlordiazepoxide and iloperidone both increase sedation. Use Caution/Monitor.iloperidone increases levels of chlordiazepoxide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.hyoscyamine sprayhyoscyamine spray and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.iloperidoneamitriptyline and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely.iloperidone and amitriptyline both increase sedation. Use Caution/Monitor.imipraminechlordiazepoxide and imipramine both increase sedation. Use Caution/Monitor.amitriptyline and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.amitriptyline and imipramine both increase sedation. Use Caution/Monitor.indacaterol, inhaledindacaterol, inhaled, amitriptyline. QTc interval. Use Caution/Monitor. Indacaterol should be administered with extreme caution to patients treated with TCAs. Drugs that are known to prolong the QTc interval may have an increased the