of interaction is not clear, use caution. Minor/Significance Unknown.norepinephrineMonitor Closely (3)albuterol and norepinephrine both decrease serum potassium. Use Caution/Monitor. albuterol and norepinephrine both decrease sedation. Use Caution/Monitor. albuterol and norepinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.nortriptylineMonitor Closely (3)albuterol and nortriptyline both increase QTc interval. Use Caution/Monitor. nortriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.Serious - Use Alternative (1)nortriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.octreotideMonitor Closely (1)albuterol and octreotide both increase QTc interval. Use Caution/Monitor.ofloxacinMonitor Closely (1)albuterol and ofloxacin both increase QTc interval. Use Caution/Monitor.olanzapineMonitor Closely (5)ipratropium decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. olanzapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. olanzapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor. albuterol and olanzapine both increase QTc interval. Use Caution/Monitor. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instancesolodaterol inhaledMonitor Closely (2)albuterol and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. albuterol and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effectsonabotulinumtoxinAMonitor Closely (1)onabotulinumtoxinA and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.ondansetronMonitor Closely (1)albuterol and ondansetron both increase QTc interval. Use Caution/Monitor.opium tinctureMonitor Closely (1)opium tincture increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.orphenadrineMonitor Closely (1)ipratropium and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.osilodrostatMonitor Closely (2)osilodrostat and albuterol both increase QTc interval. Use Caution/Monitor. albuterol and osilodrostat both increase QTc interval. Use Caution/Monitor. Dose dependent QT prolongation - avoid drugs known to prolong the QT intervalosimertinibMonitor Closely (1)albuterol and osimertinib both increase QTc interval. Use Caution/Monitor.oxaliplatinMonitor Closely (2)oxaliplatin will increase the level or effect of albuterol by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval. albuterol and oxaliplatin both increase QTc interval. Use Caution/Monitor.oxaprozinMonitor Closely (1)oxaprozin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxazepamMonitor Closely (1)oxazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxybutyninMonitor Closely (1)ipratropium and oxybutynin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.oxybutynin topicalMonitor Closely (1)ipratropium and oxybutynin topical both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.oxybutynin transdermalMonitor Closely (1)ipratropium and oxybutynin transdermal both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.oxycodoneMonitor Closely (1)oxycodone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.oxymorphoneMonitor Closely (1)oxymorphone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ozanimodMonitor Closely (1)albuterol and ozanimod both increase QTc interval. Use Caution/Monitor.paliperidoneMonitor Closely (5)albuterol and paliperidone both increase QTc interval. Use Caution/Monitor. paliperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. paliperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. ipratropium decreases levels of paliperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. ipratropium decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.pancuroniumMonitor Closely (1)ipratropium and pancuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.panobinostatMonitor Closely (1)albuterol and panobinostat both increase QTc interval. Use Caution/Monitor.papaveretumMonitor Closely (1)papaveretum increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.papaverineMonitor Closely (1)papaverine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.parecoxibMonitor Closely (1)parecoxib increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pasireotideMonitor Closely (1)albuterol and pasireotide both increase QTc interval. Use Caution/Monitor.pazopanibMonitor Closely (1)albuterol and pazopanib both increase QTc interval. Use Caution/Monitor.penbutololMonitor Closely (2)penbutolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor. penbutolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pentamidineMonitor Closely (1)albuterol and pentamidine both increase QTc interval. Use Caution/Monitor.pentazocineMonitor Closely (1)pentazocine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pentobarbitalMonitor Closely (1)pentobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.perphenazineMonitor Closely (4)ipratropium decreases levels of perphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. perphenazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor. perphenazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.phendimetrazineMonitor Closely (2)albuterol and phendimetrazine both decrease sedation. Use Caution/Monitor. albuterol and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenelzineSerious - Use Alternative (1)phenelzine increases effects of albuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.phenobarbitalMonitor Closely (1)phenobarbital increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenoxybenzamineMonitor Closely (1)phenoxybenzamine, albuterol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Hypotension, tachycardia.phentermineMonitor Closely (2)albuterol and phentermine both decrease sedation. Use Caution/Monitor. albuterol and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrineMonitor Closely (2)albuterol and phenylephrine both decrease sedation. Use Caution/Monitor. albuterol and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.phenylephrine POMonitor Closely (2)albuterol and phenylephrine PO both decrease sedation. Use Caution/Monitor. albuterol and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.pholcodineMonitor Closely (1)pholcodine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.physostigmineMonitor Closely (1)physostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pilocarpineMonitor Closely (1)pilocarpine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimavanserinMonitor Closely (1)albuterol and pimavanserin both increase QTc interval. Use Caution/Monitor.pimozideMonitor Closely (4)pimozide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor. ipratropium decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. pimozide increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.Serious - Use Alternative (1)albuterol and pimozide both increase QTc interval. Contraindicated.pindololMonitor Closely (2)pindolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor. pindolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pirbuterolMonitor Closely (3)albuterol and pirbuterol both decrease serum potassium. Use Caution/Monitor. albuterol and pirbuterol both decrease sedation. Use Caution/Monitor. albuterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.piroxicamMonitor Closely (1)piroxicam increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.pitolisantMonitor Closely (1)albuterol and pitolisant both increase QTc interval. Use Caution/Monitor.ponesimodMonitor Closely (1)albuterol and ponesimod both increase QTc interval. Use Caution/Monitor.posaconazoleMonitor Closely (1)albuterol and posaconazole both increase QTc interval. Use Caution/Monitor.potassium acid phosphateMonitor Closely (1)potassium acid phosphate increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.potassium chlorideMonitor Closely (1)potassium chloride increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.pralidoximeMonitor Closely (1)ipratropium and pralidoxime both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.pramlintideSerious - Use Alternative (1)pramlintide, ipratropium. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.primaquineMonitor Closely (1)albuterol and primaquine both increase QTc interval. Use Caution/Monitor.primidoneMonitor Closely (1)primidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.procainamideMonitor Closely (1)albuterol and procainamide both increase QTc interval. Use Caution/Monitor.procarbazineMonitor Closely (1)procarbazine increases effects of albuterol by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode.prochlorperazineMonitor Closely (4)prochlorperazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. ipratropium decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor. prochlorperazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.promethazineMonitor Closely (4)ipratropium decreases levels of promethazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. ipratropium decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor. promethazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. promethazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.propafenoneMonitor Closely (1)albuterol and propafenone both increase QTc interval. Use Caution/Monitor.propanthelineMonitor Closely (1)ipratropium and propantheline both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.propranololMonitor Closely (2)propranolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor. propranolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.propylhexedrineMonitor Closely (2)albuterol and propylhexedrine both decrease sedation. Use Caution/Monitor. albuterol and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.protriptylineMonitor Closely (3)albuterol and protriptyline both increase QTc interval. Use Caution/Monitor. protriptyline increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (1)protriptyline, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.pseudoephedrineMonitor Closely (1)albuterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.pyridostigmineMonitor Closely (1)pyridostigmine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.quazepamMonitor Closely (1)quazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.quetiapineMonitor Closely (5)ipratropium decreases levels of quetiapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. quetiapine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. albuterol and quetiapine both increase QTc interval. Use Caution/Monitor. quetiapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.quinidineMonitor Closely (1)albuterol and quinidine both increase QTc interval. Use Caution/Monitor.quinineMonitor Closely (1)albuterol and quinine both increase QTc interval. Use Caution/Monitor.ranolazineMonitor Closely (1)albuterol and ranolazine both increase QTc interval. Use Caution/Monitor.rapacuroniumMonitor Closely (1)ipratropium and rapacuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.revefenacinSerious - Use Alternative (1)revefenacin and ipratropium both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.ribociclibMonitor Closely (1)albuterol and ribociclib both increase QTc interval. Use Caution/Monitor.rilpivirineMonitor Closely (1)albuterol and rilpivirine both increase QTc interval. Use Caution/Monitor.risperidoneMonitor Closely (3)albuterol and risperidone both increase QTc interval. Use Caution/Monitor. risperidone increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. risperidone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.rocuroniumMonitor Closely (1)ipratropium and rocuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.romidepsinMonitor Closely (1)albuterol and romidepsin both increase QTc interval. Use Caution/Monitor.sacubitril/valsartanMonitor Closely (1)sacubitril/valsartan increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.sageMinor (1)sage increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.salicylates (non-asa)Monitor Closely (1)salicylates (non-asa) increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.salmeterolMonitor Closely (3)albuterol and salmeterol both decrease serum potassium. Use Caution/Monitor. albuterol and salmeterol both decrease sedation. Use Caution/Monitor.