adverse effects and toxicity.maprotilineoxazepam and maprotiline both increase sedation. Use Caution/Monitor.marijuanaoxazepam and marijuana both increase sedation. Use Caution/Monitor.melatoninoxazepam and melatonin both increase sedation. Use Caution/Monitor.meperidineoxazepam and meperidine both increase sedation. Use Caution/Monitor.meprobamateoxazepam and meprobamate both increase sedation. Use Caution/Monitor.metaproterenoloxazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxaloneoxazepam and metaxalone both increase sedation. Use Caution/Monitor.methadoneoxazepam and methadone both increase sedation. Use Caution/Monitor.methamphetamineoxazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamoloxazepam and methocarbamol both increase sedation. Use Caution/Monitor.methylenedioxymethamphetamineoxazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and oxazepam both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrineoxazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapineoxazepam and mirtazapine both increase sedation. Use Caution/Monitor.modafiniloxazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphineoxazepam and morphine both increase sedation. Use Caution/Monitor.motherwortoxazepam and motherwort both increase sedation. Use Caution/Monitor.moxonidineoxazepam and moxonidine both increase sedation. Use Caution/Monitor.nabiloneoxazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphineoxazepam and nalbuphine both increase sedation. Use Caution/Monitor.norepinephrineoxazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylineoxazepam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapineoxazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.opium tinctureoxazepam and opium tincture both increase sedation. Use Caution/Monitor.orphenadrineoxazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxycodoneoxazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphoneoxazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidoneoxazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumoxazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverineoxazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocineoxazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital and oxazepam both increase sedation. Use Caution/Monitor.perampanelperampanel and oxazepam both increase sedation. Use Caution/Monitor.perphenazineoxazepam and perphenazine both increase sedation. Use Caution/Monitor.phendimetrazineoxazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and oxazepam both increase sedation. Use Caution/Monitor.phentermineoxazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrineoxazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine POoxazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodineoxazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozideoxazepam and pimozide both increase sedation. Use Caution/Monitor.pirbuteroloxazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.pregabalinpregabalin, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone and oxazepam both increase sedation. Use Caution/Monitor.prochlorperazineoxazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and oxazepam both increase sedation. Use Caution/Monitor.propofolpropofol and oxazepam both increase sedation. Use Caution/Monitor.propylhexedrineoxazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylineoxazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamoxazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapineoxazepam and quetiapine both increase sedation. Use Caution/Monitor.ramelteonoxazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, oxazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.risperidoneoxazepam and risperidone both increase sedation. Use Caution/Monitor.salmeteroloxazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.scullcapoxazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and oxazepam both increase sedation. Use Caution/Monitor.sevofluranesevoflurane and oxazepam both increase sedation. Use Caution/Monitor.shepherd's purseoxazepam and shepherd's purse both increase sedation. Use Caution/Monitor.stiripentolstiripentol, oxazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentaniloxazepam and sufentanil both increase sedation. Use Caution/Monitor.suvorexantsuvorexant and oxazepam both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessarytapentadoloxazepam and tapentadol both increase sedation. Use Caution/Monitor.teduglutideteduglutide increases levels of oxazepam by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.temazepamoxazepam and temazepam both increase sedation. Use Caution/Monitor.terbutalineoxazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazineoxazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixeneoxazepam and thiothixene both increase sedation. Use Caution/Monitor.topiramateoxazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadoloxazepam and tramadol both increase sedation. Use Caution/Monitor.trazodoneoxazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamoxazepam and triazolam both increase sedation. Use Caution/Monitor.triclofosoxazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazineoxazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipramineoxazepam and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and oxazepam both increase sedation. Use Caution/Monitor.xylometazolineoxazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbineoxazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotideoxazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneoxazepam and ziprasidone both increase sedation. Use Caution/Monitor.zotepineoxazepam and zotepine both increase sedation. Use Caution/Monitor.Minor (15)brimonidinebrimonidine increases effects of oxazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.eucalyptusoxazepam and eucalyptus both increase sedation. Minor/Significance Unknown.fleroxacinfleroxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.gemifloxacingemifloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.green teagreen tea decreases effects of oxazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.labetalollabetalol increases effects of oxazepam by decreasing metabolism. Minor/Significance Unknown.levofloxacinlevofloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.metoprololmetoprolol increases effects of oxazepam by decreasing metabolism. Minor/Significance Unknown.moxifloxacinmoxifloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.ofloxacinofloxacin increases levels of oxazepam by decreasing metabolism. Minor/Significance Unknown.propranololpropranolol increases effects of oxazepam by decreasing metabolism. Minor/Significance Unknown.rifabutinrifabutin decreases levels of oxazepam by increasing metabolism. Minor/Significance Unknown.sageoxazepam and sage both increase sedation. Minor/Significance Unknown.vinpocetineoxazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).zolpidemzolpidem, oxazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.acrivastineMonitor Closely (1)acrivastine and oxazepam both increase sedation. Use Caution/Monitor.albuterolMonitor Closely (1)oxazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfentanilMonitor Closely (1)oxazepam and alfentanil both increase sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam and oxazepam both increase sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and oxazepam both increase sedation. Use Caution/Monitor.amitriptylineMonitor Closely (1)oxazepam and amitriptyline both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)amobarbital and oxazepam both increase sedation. Use Caution/Monitor.amoxapineMonitor Closely (1)oxazepam and amoxapine both increase sedation. Use Caution/Monitor.apomorphineMonitor Closely (1)oxazepam and apomorphine both increase sedation. Use Caution/Monitor.arformoterolMonitor Closely (1)oxazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.aripiprazoleMonitor Closely (1)oxazepam and aripiprazole both increase sedation. Use Caution/Monitor.armodafinilMonitor Closely (1)oxazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.asenapineMonitor Closely (1)asenapine and oxazepam both increase sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and oxazepam both increase sedation. Use Caution/Monitor.avapritinibMonitor Closely (1)avapritinib and oxazepam both increase sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine and oxazepam both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)oxazepam and baclofen both increase sedation. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)oxazepam and belladonna and opium both increase sedation. Use Caution/Monitor.benperidolMonitor Closely (1)oxazepam and benperidol both increase sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (2)benzhydrocodone/acetaminophen, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. benzhydrocodone/acetaminophen and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebenzphetamineMonitor Closely (1)oxazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brexanoloneMonitor Closely (1)brexanolone, oxazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexpiprazole and oxazepam both increase sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and oxazepam both increase sedation. Use Caution/Monitor.Minor (1)brimonidine increases effects of oxazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.brivaracetamMonitor Closely (1)brivaracetam and oxazepam both increase sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brompheniramine and oxazepam both increase sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)oxazepam and buprenorphine both increase sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)oxazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)oxazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.Serious - Use Alternative (1)buprenorphine subdermal implant and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine transdermalSerious - Use Alternative (1)buprenorphine transdermal and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebuprenorphine, long-acting injectionMonitor Closely (1)oxazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.Serious - Use Alternative (1)buprenorphine, long-acting injection and oxazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequatebutabarbitalMonitor Closely (1)butabarbital and oxazepam both increase sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital and oxazepam both increase sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)oxazepam and butorphanol both increase sedation. Use Caution/Monitor.caffeineMonitor Closely (1)oxazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesSerious - Use Alternative (1)oxazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.carbinoxamineMonitor Closely (1)carbinoxamine and oxazepam both increase sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)oxazepam and carisoprodol both increase sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, oxazepam. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateMonitor Closely (1)oxazepam and chloral hydrate both increase sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide and oxazepam both increase sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine and oxazepam both increase sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)oxazepam and chlorpromazine both increase sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)oxazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.cinnarizineMonitor Closely (1)cinnarizine and oxazepam both increase sedation. Use Caution/Monitor.clemastineMonitor Closely (1)clemastine and oxazepam both increase sedation. Use Caution/Monitor.clobazamMonitor Closely (1)oxazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clomipramineMonitor Closely (1)oxazepam and clomipramine both increase sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)clonazepam and oxazepam both increase sedation. Use Caution/Monitor.clonidineMonitor Closely (1)clonidine, oxazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.clorazepateMonitor Closely (1)clorazepate and oxazepam both increase sedation. Use Caution/Monitor.clozapineMonitor Closely (1)oxazepam and clozapine both increase sedation. Use Caution/Monitor.codeineMonitor Closely (1)oxazepam and codeine both increase sedation. Use