AdultPediatricDosage Forms & Strengths injectable solution 20mg/mL COPD Associated with Acute Hypercapnia 1-2 mg/min IV infusion; not to exceed 3 mg/min or 2 hours; monitor arterial blood gases prior to initiation of infusion and at 30 min interval during the infusion to identify possible development of acidosis/CO2 retention Respiratory Depression Postanesthesia 0.5-1 mg/kg IV injection; repeat at 5-min intervals in patients that show an initial response; not to exceed 2 mg/kg OR Initial: 5 mg/min IV infusion (with 1 mg/mL solution) until adequate response or adverse effects occur; may reduce to 1-3 mg/min; total IV infusion not to exceed 4 mg/kg Drug-Induced CNS Depression Intermittent injection: 1-2 mg/kg IV injection priming dose, repeat in 1-2 hr priming dose; not to exceed 3 g/day; may repeat in 24 hr if necessary OR IV infusion: 1-2 mg/kg IV injection, repeat in 5 min, if no response, wait 1-2 hr and repeat priming dose; if some stimulation noted, initiate infusion at 1-3 mg/min IV infusion not to exceed 2 hours; suspend infusion if patient begins to awaken; may repeat after a rest of 30-120 minutes, total dose not to exceed 3 g/dayDosage Forms & Strengths injectable solution 20mg/mL <12 years Safety & efficacy not established >12 years COPD Associated with Acute Hypercapnia 1-2 mg/min IV infusion; not to exceed 3 mg/min or 2 hours; monitor arterial blood gases prior to initiation of infusion and at 30 min interval during the infusion to identify possible development of acidosis/CO2 retention Respiratory Depression Postanesthesia 0.5-1 mg/kg IV injection; repeat at 5-min intervals in patients that show an initial response; not to exceed 2 mg/kg OR IV infusion: 1-2 mg/kg IV injection, repeat in 5 min, if no response, wait 1-2 hr and repeat priming dose; if some stimulation noted, initiate infusion at 1-3 mg/min IV infusion not to exceed 2 hours; suspend infusion if patient begins to awaken; may repeat after a rest of 30-120 minutes, total dose not to exceed 3 g/day Drug-Induced CNS Depression Intermittent injection: 1-2 mg/kg IV injection priming dose, repeat in 1-2 hr priming dose; not to exceed 3 g/day; may repeat in 24 hr if necessary OR IV infusion: 1-2 mg/kg IV injection, repeat in 5 min, if no response, wait 1-2 hr and repeat priming dose; if some stimulation noted, initiate infusion at 1-3 mg/min IV infusion not to exceed 2 hours; suspend infusion if patient begins to awaken; may repeat after a rest of 30-120 minutes, total dose not to exceed 3 g/day Interaction CheckerEnter a drug name and doxapramNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (35)benzphetaminedoxapram increases effects of benzphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.desfluranedoxapram, desflurane. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.dexfenfluraminedoxapram increases effects of dexfenfluramine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dexmethylphenidatedoxapram increases effects of dexmethylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dextroamphetaminedoxapram increases effects of dextroamphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.diethylpropiondoxapram increases effects of diethylpropion by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dobutaminedoxapram increases effects of dobutamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dopaminedoxapram increases effects of dopamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.ephedrinedoxapram increases effects of ephedrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.epinephrinedoxapram increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.etomidatedoxapram, etomidate. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.fenfluraminedoxapram increases effects of fenfluramine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.isocarboxaziddoxapram increases effects of isocarboxazid by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.isoproterenoldoxapram increases effects of isoproterenol by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.ketaminedoxapram, ketamine. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.linezoliddoxapram increases effects of linezolid by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.lisdexamfetaminedoxapram increases effects of lisdexamfetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.methamphetaminedoxapram increases effects of methamphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.methylenedioxymethamphetaminedoxapram increases effects of methylenedioxymethamphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.methylphenidatedoxapram increases effects of methylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.midodrinedoxapram increases effects of midodrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.norepinephrinedoxapram increases effects of norepinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phendimetrazinedoxapram increases effects of phendimetrazine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phenelzinedoxapram increases effects of phenelzine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phenterminedoxapram increases effects of phentermine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phenylephrinedoxapram increases effects of phenylephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phenylephrine POdoxapram increases effects of phenylephrine PO by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.propofoldoxapram, propofol. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.propylhexedrinedoxapram increases effects of propylhexedrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.pseudoephedrinedoxapram increases effects of pseudoephedrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.serdexmethylphenidate/dexmethylphenidatedoxapram increases effects of serdexmethylphenidate/dexmethylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.sevofluranedoxapram, sevoflurane. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.tranylcyprominedoxapram increases effects of tranylcypromine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.xylometazolinedoxapram increases effects of xylometazoline by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.yohimbinedoxapram increases effects of yohimbine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.Monitor Closely (11)atracuriumdoxapram decreases effects of atracurium by pharmacodynamic antagonism. Use Caution/Monitor.cisatracuriumdoxapram decreases effects of cisatracurium by pharmacodynamic antagonism. Use Caution/Monitor.onabotulinumtoxinAdoxapram decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Use Caution/Monitor.pancuroniumdoxapram decreases effects of pancuronium by pharmacodynamic antagonism. Use Caution/Monitor.procarbazinedoxapram increases effects of procarbazine by pharmacodynamic synergism. Use Caution/Monitor. Additive pressor effect.rapacuroniumdoxapram decreases effects of rapacuronium by pharmacodynamic antagonism. Use Caution/Monitor.rocuroniumdoxapram decreases effects of rocuronium by pharmacodynamic antagonism. Use Caution/Monitor.solriamfetoldoxapram and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.succinylcholinedoxapram decreases effects of succinylcholine by pharmacodynamic antagonism. Use Caution/Monitor.theophyllinedoxapram, theophylline. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Increased skeletal muscle activity, agitation, hyperactivity.vecuroniumdoxapram decreases effects of vecuronium by pharmacodynamic antagonism. Use Caution/Monitor.Minor (0)atracuriumMonitor Closely (1)doxapram decreases effects of atracurium by pharmacodynamic antagonism. Use Caution/Monitor.benzphetamineSerious - Use Alternative (1)doxapram increases effects of benzphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.cisatracuriumMonitor Closely (1)doxapram decreases effects of cisatracurium by pharmacodynamic antagonism. Use Caution/Monitor.desfluraneSerious - Use Alternative (1)doxapram, desflurane. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.dexfenfluramineSerious - Use Alternative (1)doxapram increases effects of dexfenfluramine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dexmethylphenidateSerious - Use Alternative (1)doxapram increases effects of dexmethylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dextroamphetamineSerious - Use Alternative (1)doxapram increases effects of dextroamphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.diethylpropionSerious - Use Alternative (1)doxapram increases effects of diethylpropion by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dobutamineSerious - Use Alternative (1)doxapram increases effects of dobutamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.dopamineSerious - Use Alternative (1)doxapram increases effects of dopamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.ephedrineSerious - Use Alternative (1)doxapram increases effects of ephedrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.epinephrineSerious - Use Alternative (1)doxapram increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.etomidateSerious - Use Alternative (1)doxapram, etomidate. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.fenfluramineSerious - Use Alternative (1)doxapram increases effects of fenfluramine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.isocarboxazidSerious - Use Alternative (1)doxapram increases effects of isocarboxazid by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.isoproterenolSerious - Use Alternative (1)doxapram increases effects of isoproterenol by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.ketamineSerious - Use Alternative (1)doxapram, ketamine. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.linezolidSerious - Use Alternative (1)doxapram increases effects of linezolid by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.lisdexamfetamineSerious - Use Alternative (1)doxapram increases effects of lisdexamfetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.methamphetamineSerious - Use Alternative (1)doxapram increases effects of methamphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.methylenedioxymethamphetamineSerious - Use Alternative (1)doxapram increases effects of methylenedioxymethamphetamine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.methylphenidateSerious - Use Alternative (1)doxapram increases effects of methylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.midodrineSerious - Use Alternative (1)doxapram increases effects of midodrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.norepinephrineSerious - Use Alternative (1)doxapram increases effects of norepinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.onabotulinumtoxinAMonitor Closely (1)doxapram decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Use Caution/Monitor.pancuroniumMonitor Closely (1)doxapram decreases effects of pancuronium by pharmacodynamic antagonism. Use Caution/Monitor.phendimetrazineSerious - Use Alternative (1)doxapram increases effects of phendimetrazine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phenelzineSerious - Use Alternative (1)doxapram increases effects of phenelzine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phentermineSerious - Use Alternative (1)doxapram increases effects of phentermine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phenylephrineSerious - Use Alternative (1)doxapram increases effects of phenylephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.phenylephrine POSerious - Use Alternative (1)doxapram increases effects of phenylephrine PO by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.procarbazineMonitor Closely (1)doxapram increases effects of procarbazine by pharmacodynamic synergism. Use Caution/Monitor. Additive pressor effect.propofolSerious - Use Alternative (1)doxapram, propofol. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.propylhexedrineSerious - Use Alternative (1)doxapram increases effects of propylhexedrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.pseudoephedrineSerious - Use Alternative (1)doxapram increases effects of pseudoephedrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.rapacuroniumMonitor Closely (1)doxapram decreases effects of rapacuronium by pharmacodynamic antagonism. Use Caution/Monitor.rocuroniumMonitor Closely (1)doxapram decreases effects of rocuronium by pharmacodynamic antagonism. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidateSerious - Use Alternative (1)doxapram increases effects of serdexmethylphenidate/dexmethylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.sevofluraneSerious - Use Alternative (1)doxapram, sevoflurane. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.solriamfetolMonitor Closely (1)doxapram and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.succinylcholineMonitor Closely (1)doxapram decreases effects of succinylcholine by pharmacodynamic antagonism. Use Caution/Monitor.theophyllineMonitor Closely (1)doxapram, theophylline. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Increased skeletal muscle activity, agitation, hyperactivity.tranylcypromineSerious - Use Alternative (1)doxapram increases effects of tranylcypromine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.vecuroniumMonitor Closely (1)doxapram decreases effects of vecuronium by pharmacodynamic antagonism. Use Caution/Monitor.xylometazolineSerious - Use Alternative (1)doxapram increases effects of xylometazoline by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.yohimbineSerious - Use Alternative (1)doxapram increases effects of yohimbine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect. Frequency Not Defined Pyrexia Flushing Sweating Pruritus & paresthesia, burning/hot sensation especially in genitalia & perineum Disorientation Pupillary dilatation Hallucinations Involuntary movements Muscle spasticity, muscle fasciculations, increased deep tendon reflexes, clonus, bilateral Babinski, convulsions Dyspnea Cough Hyperventilation/ rebound hypoventilation Tachypnea Laryngospasm Bronchospasm Hiccough Phlebitis Variations in heart rate Lowered T-waves, arrhythmias Chest pain, tightness in chest Increase in blood pressure Stimulation of urinary bladder with spontaneous voiding, urinary retention Elevation of BUN, albuminuria Hemolysis (with rapid infusion) Decrease in Hgb, Hct, or RBC count Decrease in WBC (pts with leukopenia) Contraindications Hypersensitivity Epilepsy, convulsive disorder Existing/suspected pulmonary embolism Mechanical