Caution/Monitor.oseltamivirprobenecid increases levels of oseltamivir by Other (see comment). Use Caution/Monitor. Comment: Coadministration of probenecid results in a 2-fold increase in exposure to oseltamivir carboxylate because of a decrease in active anionic tubular secretion in the kidney. No dosage adjustments are required with probenecid coadministration.oxaprozinoxaprozin will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.parecoxibparecoxib will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.penicillin G aqueousprobenecid increases levels of penicillin G aqueous by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.piperacillinprobenecid will increase the level or effect of piperacillin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.piroxicampiroxicam will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.pralatrexateprobenecid increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor.pyrazinamidepyrazinamide decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.rifampinprobenecid will increase the level or effect of rifampin by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use with probenecid increase concentration of rifampin which may increase risk of toxicity; monitor for adverse reactions during coadministrationrose hipsrose hips will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.salicylates (non-asa)salicylates (non-asa) will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.salicylates (non-asa) decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.salsalatesalsalate will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.salsalate decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.sodium phenylacetateprobenecid increases levels of sodium phenylacetate by decreasing renal clearance. Use Caution/Monitor.sodium phenylbutyrateprobenecid increases levels of sodium phenylbutyrate by decreasing renal clearance. Use Caution/Monitor.sulfasalazinesulfasalazine will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.sulfasalazine decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.sulindacsulindac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.tenofovir DFprobenecid increases levels of tenofovir DF by decreasing renal clearance. Use Caution/Monitor. Potential for increased toxicity. .tolazamideprobenecid increases levels of tolazamide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.tolbutamideprobenecid increases levels of tolbutamide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.tolfenamic acidtolfenamic acid will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.tolmetintolmetin will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.valganciclovirprobenecid will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.willow barkwillow bark will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.willow bark decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.zidovudineprobenecid increases levels of zidovudine by decreasing metabolism. Use Caution/Monitor.Minor (22)aztreonamprobenecid increases levels of aztreonam by decreasing elimination. Minor/Significance Unknown.benazeprilprobenecid increases levels of benazepril by Other (see comment). Minor/Significance Unknown. Comment: Probenecid may decrease the renal excretion of benazepril; monitor blood pressure.captoprilprobenecid increases effects of captopril by unspecified interaction mechanism. Minor/Significance Unknown.dapsoneprobenecid increases levels of dapsone by decreasing elimination. Minor/Significance Unknown.enalaprilprobenecid increases effects of enalapril by unspecified interaction mechanism. Minor/Significance Unknown.ertapenemprobenecid increases levels of ertapenem by decreasing elimination. Minor/Significance Unknown.fosinoprilprobenecid increases effects of fosinopril by unspecified interaction mechanism. Minor/Significance Unknown.gemifloxacinprobenecid increases levels of gemifloxacin by decreasing renal clearance. Minor/Significance Unknown.imidaprilprobenecid increases effects of imidapril by unspecified interaction mechanism. Minor/Significance Unknown.lisinoprilprobenecid increases effects of lisinopril by unspecified interaction mechanism. Minor/Significance Unknown.methohexitalprobenecid increases levels of methohexital by unknown mechanism. Minor/Significance Unknown.moexiprilprobenecid increases effects of moexipril by unspecified interaction mechanism. Minor/Significance Unknown.penicillin VKprobenecid will increase the level or effect of penicillin VK by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.perindoprilprobenecid increases effects of perindopril by unspecified interaction mechanism. Minor/Significance Unknown.primaquineprimaquine, probenecid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Risk of hemolysis in G6PD deficient pts.quinaprilprobenecid increases effects of quinapril by unspecified interaction mechanism. Minor/Significance Unknown.ramiprilprobenecid increases effects of ramipril by unspecified interaction mechanism. Minor/Significance Unknown.sulfadiazineprobenecid increases levels of sulfadiazine by unspecified interaction mechanism. Minor/Significance Unknown.sulfamethoxazoleprobenecid increases levels of sulfamethoxazole by unspecified interaction mechanism. Minor/Significance Unknown.sulfisoxazoleprobenecid increases levels of sulfisoxazole by unspecified interaction mechanism. Minor/Significance Unknown.trandolaprilprobenecid increases effects of trandolapril by unspecified interaction mechanism. Minor/Significance Unknown.valacyclovirprobenecid increases levels of valacyclovir by decreasing renal clearance. Minor/Significance Unknown.aceclofenacMonitor Closely (1)aceclofenac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.acemetacinMonitor Closely (1)acemetacin will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.acyclovirMonitor Closely (1)acyclovir will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.aminohippurate sodiumMonitor Closely (1)aminohippurate sodium will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.aspirinSerious - Use Alternative (1)aspirin decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Aspirin decreases uricosuric action of probenecid.aspirin rectalSerious - Use Alternative (1)aspirin rectal decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Aspirin decreases uricosuric action of probenecid.aspirin/citric acid/sodium bicarbonateMonitor Closely (1)aspirin/citric acid/sodium bicarbonate decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.Serious - Use Alternative (1)aspirin/citric acid/sodium bicarbonate decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. Aspirin decreases uricosuric action of probenecid.aztreonamMinor (1)probenecid increases levels of aztreonam by decreasing elimination. Minor/Significance Unknown.balsalazideMonitor Closely (2)balsalazide will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. balsalazide decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.baricitinibSerious - Use Alternative (1)probenecid will increase the level or effect of baricitinib by decreasing elimination. Avoid or Use Alternate Drug. Coadministration of baricitinib with strong organic anion transporter 3 (OAT3) inhibitors is not recommended.benazeprilMinor (1)probenecid increases levels of benazepril by Other (see comment). Minor/Significance Unknown. Comment: Probenecid may decrease the renal excretion of benazepril; monitor blood pressure.bendroflumethiazideMonitor Closely (1)bendroflumethiazide will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cabozantinibMonitor Closely (1)probenecid will increase the level or effect of cabozantinib by Other (see comment). Use Caution/Monitor. MRP2 inhibitors increase cabozantinib toxicitycaptoprilMinor (1)probenecid increases effects of captopril by unspecified interaction mechanism. Minor/Significance Unknown.cefaclorMonitor Closely (1)cefaclor will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefadroxilMonitor Closely (1)cefadroxil will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefamandoleMonitor Closely (1)cefamandole will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefazolinMonitor Closely (1)probenecid increases levels of cefazolin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefdinirMonitor Closely (1)probenecid will increase the level or effect of cefdinir by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefditorenMonitor Closely (1)probenecid will increase the level or effect of cefditoren by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefepimeMonitor Closely (1)probenecid will increase the level or effect of cefepime by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefiximeMonitor Closely (1)probenecid will increase the level or effect of cefixime by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefotaximeMonitor Closely (1)probenecid will increase the level or effect of cefotaxime by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefotetanMonitor Closely (1)probenecid will increase the level or effect of cefotetan by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefoxitinMonitor Closely (1)probenecid will increase the level or effect of cefoxitin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefpiromeMonitor Closely (1)cefpirome will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefpodoximeMonitor Closely (1)probenecid will increase the level or effect of cefpodoxime by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefprozilMonitor Closely (1)probenecid will increase the level or effect of cefprozil by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.ceftarolineMonitor Closely (1)probenecid increases levels of ceftaroline by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.ceftazidimeMonitor Closely (1)probenecid will increase the level or effect of ceftazidime by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.ceftazidime/avibactamMonitor Closely (1)probenecid increases levels of ceftazidime/avibactam by decreasing renal clearance. Use Caution/Monitor. Avoid, coadministration not recommended according to the prescribing information. In vitro, probenecid inhibits uptake of avibactam by OATP1 and OATP3 transporters in the kidney by 56-70%. This may result in decreased renal elimination of avibactam.ceftibutenMonitor Closely (1)ceftibuten will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.ceftriaxoneMonitor Closely (1)probenecid will increase the level or effect of ceftriaxone by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cefuroximeMonitor Closely (1)probenecid will increase the level or effect of cefuroxime by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.celecoxibMonitor Closely (1)celecoxib will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.cephalexinMonitor Closely (1)cephalexin will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.chlorothiazideMonitor Closely (1)chlorothiazide will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.chlorpropamideMonitor Closely (2)chlorpropamide will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. probenecid increases levels of chlorpropamide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.chlorthalidoneMonitor Closely (1)chlorthalidone will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.choline magnesium trisalicylateMonitor Closely (2)choline magnesium trisalicylate will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. choline magnesium trisalicylate decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.ciprofloxacinMonitor Closely (1)probenecid will increase the level or effect of ciprofloxacin by Other (see comment). Use Caution/Monitor. Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the ciprofloxacin levels in the serumcyclopenthiazideMonitor Closely (1)cyclopenthiazide will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.dapsoneMinor (1)probenecid increases levels of dapsone by decreasing elimination. Minor/Significance Unknown.deferiproneMonitor Closely (1)probenecid will increase the level or effect of deferiprone by decreasing metabolism. Use Caution/Monitor. Coadministration with UGT1A6 inhibitors may increase serum concentration of deferiprone.diclofenacMonitor Closely (1)diclofenac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.dicloxacillinMonitor Closely (1)probenecid increases levels of dicloxacillin by decreasing renal clearance. Use Caution/Monitor.diflunisalMonitor Closely (2)diflunisal will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. diflunisal decreases effects of probenecid by unknown mechanism. Use Caution/Monitor.enalaprilMinor (1)probenecid increases effects of enalapril by unspecified interaction mechanism. Minor/Significance Unknown.ertapenemMinor (1)probenecid increases levels of ertapenem by decreasing elimination. Minor/Significance Unknown.ethambutolMonitor Closely (1)ethambutol decreases effects of probenecid by Other (see comment). Use Caution/Monitor. Comment: Hyperuricemia reported with ethambutol and precipitation of gout reported; uric acid lowering agents may be require dosage adjustment.etodolacMonitor Closely (1)etodolac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.famciclovirMonitor Closely (1)probenecid increases levels of famciclovir by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Coadministration of famciclovir with drugs that are significantly eliminated by active renal tubular secretion may increase plasma concentrations of famciclovir's active moiety (ie, penciclovir).fenoprofenMonitor Closely (1)fenoprofen will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.flurbiprofenMonitor Closely (1)flurbiprofen will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.fosinoprilMinor (1)probenecid increases effects of fosinopril by unspecified interaction mechanism. Minor/Significance Unknown.ganciclovirMonitor Closely (1)ganciclovir will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.gemifloxacinMinor (1)probenecid increases levels of gemifloxacin by decreasing renal clearance. Minor/Significance Unknown.glimepirideMonitor Closely (1)probenecid increases levels of glimepiride by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.glipizideMonitor Closely (1)probenecid increases levels of glipizide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.glyburideMonitor Closely