and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levofloxacinmaprotiline and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.levorphanollevorphanol and maprotiline both increase sedation. Use Caution/Monitor.lisdexamfetaminemaprotiline increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lithiummaprotiline and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.lofepraminelofepramine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.lofepramine and maprotiline both increase sedation. Use Caution/Monitor.lofexidinemaprotiline and lofexidine both increase sedation. Use Caution/Monitor.maprotiline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.loprazolamloprazolam and maprotiline both increase sedation. Use Caution/Monitor.lorazepamlorazepam and maprotiline both increase sedation. Use Caution/Monitor.lorcaserinlorcaserin will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.lormetazepamlormetazepam and maprotiline both increase sedation. Use Caution/Monitor.loxapineloxapine and maprotiline both increase sedation. Use Caution/Monitor.loxapine inhaledloxapine inhaled and maprotiline both increase sedation. Use Caution/Monitor.lsdmaprotiline and lsd both increase serotonin levels. Modify Therapy/Monitor Closely.lurasidonelurasidone increases effects of maprotiline by Other (see comment). Use Caution/Monitor. Comment: Potential for additive CNS effects .marijuanamaprotiline and marijuana both increase sedation. Use Caution/Monitor.meclizinemeclizine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.melatoninmaprotiline and melatonin both increase sedation. Use Caution/Monitor.meperidinemeperidine and maprotiline both increase sedation. Use Caution/Monitor.meprobamatemaprotiline and meprobamate both increase sedation. Use Caution/Monitor.metaproterenolmaprotiline increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonemetaxalone and maprotiline both increase sedation. Use Caution/Monitor.methadonemaprotiline and methadone both increase QTc interval. Modify Therapy/Monitor Closely.methadone and maprotiline both increase sedation. Use Caution/Monitor.methamphetaminemaprotiline increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolmethocarbamol and maprotiline both increase sedation. Use Caution/Monitor.methscopolaminemethscopolamine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.methylenedioxymethamphetaminemaprotiline increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and maprotiline both increase sedation. Use Caution/Monitor.midazolam intranasalmidazolam intranasal, maprotiline. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinemaprotiline increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristonemifepristone, maprotiline. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.mirabegronmirabegron will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.mirtazapinemaprotiline and mirtazapine both increase sedation. Use Caution/Monitor.maprotiline and mirtazapine both increase serotonin levels. Modify Therapy/Monitor Closely.modafinilmaprotiline increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinemorphine and maprotiline both increase sedation. Use Caution/Monitor.maprotiline and morphine both increase serotonin levels. Modify Therapy/Monitor Closely.motherwortmaprotiline and motherwort both increase sedation. Use Caution/Monitor.moxonidinemaprotiline and moxonidine both increase sedation. Use Caution/Monitor.nabilonemaprotiline and nabilone both increase sedation. Use Caution/Monitor.nalbuphinenalbuphine and maprotiline both increase sedation. Use Caution/Monitor.naratriptannaratriptan and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.nefopamnefopam, maprotiline. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Use combination with caution.neostigmineneostigmine increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.norepinephrinemaprotiline increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.maprotiline increases effects of norepinephrine by unknown mechanism. Use Caution/Monitor.nortriptylinemaprotiline and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.maprotiline and nortriptyline both increase sedation. Use Caution/Monitor.ofloxacinmaprotiline and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.olanzapineolanzapine and maprotiline both increase sedation. Use Caution/Monitor.oliceridinemaprotiline, oliceridine. Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely.olodaterol inhaledmaprotiline and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmiasonabotulinumtoxinAonabotulinumtoxinA and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.opium tinctureopium tincture and maprotiline both increase sedation. Use Caution/Monitor.orphenadrinemaprotiline and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and maprotiline both increase sedation. Use Caution/Monitor.osimertinibosimertinib and maprotiline both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.oxazepamoxazepam and maprotiline both increase sedation. Use Caution/Monitor.oxybutyninoxybutynin and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin topicaloxybutynin topical and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.oxybutynin transdermaloxybutynin transdermal and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.oxycodoneoxycodone and maprotiline both increase sedation. Use Caution/Monitor.oxymorphoneoxymorphone and maprotiline both increase sedation. Use Caution/Monitor.ozanimodozanimod and maprotiline both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.paliperidonemaprotiline and paliperidone both increase QTc interval. Modify Therapy/Monitor Closely.paliperidone and maprotiline both increase sedation. Use Caution/Monitor.pancuroniumpancuronium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.papaveretumpapaveretum and maprotiline both increase sedation. Use Caution/Monitor.papaverinemaprotiline and papaverine both increase sedation. Use Caution/Monitor.paroxetinemaprotiline and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely.pasireotidemaprotiline and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.pazopanibmaprotiline and pazopanib both increase QTc interval. Use Caution/Monitor.peginterferon alfa 2bpeginterferon alfa 2b, maprotiline. Other (see comment). Use Caution/Monitor. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate.pentazocinepentazocine and maprotiline both increase sedation. Use Caution/Monitor.maprotiline and pentazocine both increase serotonin levels. Modify Therapy/Monitor Closely.pentobarbitalpentobarbital and maprotiline both increase sedation. Use Caution/Monitor.perphenazineperphenazine and maprotiline both increase sedation. Use Caution/Monitor.phendimetrazinemaprotiline increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenobarbitalphenobarbital and maprotiline both increase sedation. Use Caution/Monitor.phenterminemaprotiline increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrinemaprotiline increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.phenylephrine ophthalmicmaprotiline, phenylephrine ophthalmic. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenylephrine POmaprotiline increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .pholcodinemaprotiline and pholcodine both increase sedation. Use Caution/Monitor.physostigminephysostigmine increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pilocarpinepilocarpine increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.pimozidepimozide and maprotiline both increase sedation. Use Caution/Monitor.pirbuterolmaprotiline increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.posaconazolemaprotiline and posaconazole both increase QTc interval. Modify Therapy/Monitor Closely.pralidoximepralidoxime and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.pregabalinpregabalin, maprotiline. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primaquineprimaquine and maprotiline both increase QTc interval. Use Caution/Monitor.primidoneprimidone and maprotiline both increase sedation. Use Caution/Monitor.prochlorperazineprochlorperazine and maprotiline both increase QTc interval. Use Caution/Monitor.prochlorperazine and maprotiline both increase sedation. Use Caution/Monitor.promethazinepromethazine and maprotiline both increase QTc interval. Use Caution/Monitor.promethazine and maprotiline both increase sedation. Use Caution/Monitor.propanthelinepropantheline and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.propofolpropofol and maprotiline both increase sedation. Use Caution/Monitor.propylhexedrinemaprotiline increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinemaprotiline and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.maprotiline and protriptyline both increase sedation. Use Caution/Monitor.pyridostigminepyridostigmine increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.quazepamquazepam and maprotiline both increase sedation. Use Caution/Monitor.quetiapinequetiapine and maprotiline both increase sedation. Use Caution/Monitor.quetiapine, maprotiline. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT.quininemaprotiline and quinine both increase QTc interval. Use Caution/Monitor.ramelteonmaprotiline and ramelteon both increase sedation. Use Caution/Monitor.ranolazinemaprotiline and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.rapacuroniumrapacuronium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.remimazolamremimazolam, maprotiline. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.rifabutinrifabutin decreases levels of maprotiline by increasing metabolism. Use Caution/Monitor.rilpivirinerilpivirine increases toxicity of maprotiline by QTc interval. Use Caution/Monitor. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsade de Pointes.risperidonemaprotiline and risperidone both increase QTc interval. Modify Therapy/Monitor Closely.risperidone and maprotiline both increase sedation. Use Caution/Monitor.rivastigminerivastigmine increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.rizatriptanrizatriptan and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.rocuroniumrocuronium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.rolapitantrolapitant will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.romidepsinmaprotiline and romidepsin both increase QTc interval. Modify Therapy/Monitor Closely.salmeterolmaprotiline increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.SAMemaprotiline and SAMe both increase serotonin levels. Modify Therapy/Monitor Closely.scopolaminescopolamine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.scullcapmaprotiline and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital and maprotiline both increase sedation. Use Caution/Monitor.selpercatinibselpercatinib increases toxicity of maprotiline by QTc interval. Use Caution/Monitor.sertralinesertraline and maprotiline both increase QTc interval. Use Caution/Monitor.sevofluranesevoflurane and maprotiline both increase sedation. Use Caution/Monitor.shepherd's pursemaprotiline and shepherd's purse both increase sedation. Use Caution/Monitor.solifenacinsolifenacin and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.sorafenibsorafenib and maprotiline both increase QTc interval. Use Caution/Monitor.stiripentolstiripentol, maprotiline. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.succinylcholinesuccinylcholine increases and maprotiline decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.sufentanilsufentanil and maprotiline both increase sedation. Use Caution/Monitor.sufentanil SLsufentanil SL, maprotiline. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.sulfamethoxazolemaprotiline and sulfamethoxazole both increase QTc interval. Modify Therapy/Monitor Closely.sumatriptansumatriptan and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.sumatriptan intranasalsumatriptan intranasal and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.sunitinibsunitinib and maprotiline both increase QTc interval. Use Caution/Monitor.tacrolimustacrolimus and maprotiline both increase QTc interval. Use Caution/Monitor.tapentadoltapentadol and maprotiline both increase sedation. Use Caution/Monitor.telavancinmaprotiline and telavancin both increase QTc interval. Modify Therapy/Monitor Closely.temazepamtemazepam and maprotiline both increase sedation. Use Caution/Monitor.terbinafineterbinafine will increase the level or effect of maprotiline by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Assess need to reduce dose of CYP2D6-metabolized drug.terbutalinemaprotiline increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazinethioridazine and maprotiline both increase sedation. Use Caution/Monitor.thiothixenethiothixene and maprotiline both increase sedation. Use Caution/Monitor.tiotropiumtiotropium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.tolterodinetolterodine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.topiramatemaprotiline and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadoltramadol and maprotiline both increase sedation. Use Caution/Monitor.maprotiline and tramadol both increase serotonin levels. Modify Therapy/Monitor Closely.trazodonemaprotiline and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.maprotiline and trazodone both increase sedation. Use Caution/Monitor.triazolamtriazolam and maprotiline both increase sedation. Use Caution/Monitor.triclofostriclofos and maprotiline both increase sedation. Use Caution/Monitor.trifluoperazinetrifluoperazine and maprotiline both increase sedation. Use Caution/Monitor.trihexyphenidyltrihexyphenidyl and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.trimethoprimmaprotiline and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely.trimipraminemaprotiline and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.maprotiline and trimipramine both increase sedation. Use Caution/Monitor.triprolidinetriprolidine and maprotiline both increase sedation. Use Caution/Monitor.tropisetronmaprotiline and tropisetron both increase QTc interval. Modify Therapy/Monitor Closely.trospium chloridetrospium chloride and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.valbenazinevalbenazine and maprotiline both increase QTc interval. Use Caution/Monitor.vecuroniumvecuronium and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.venlafaxinemaprotiline and venlafaxine both increase QTc interval. Modify Therapy/Monitor Closely.voclosporinvoclosporin, maprotiline. Either increases effects of the other by QTc interval. Use Caution/Monitor.voriconazolemaprotiline and voriconazole both increase QTc interval. Modify Therapy/Monitor Closely.xylometazolinemaprotiline increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.yohimbinemaprotiline increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziconotidemaprotiline and ziconotide both increase sedation. Use Caution/Monitor.ziprasidoneziprasidone and maprotiline both increase sedation. Use Caution/Monitor.zolmitriptanzolmitriptan and maprotiline both increase serotonin levels. Modify Therapy/Monitor Closely.Minor (70)acarbosemaprotiline increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown.amobarbitalamobarbital, maprotiline. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.atropinemaprotiline