Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .buprenorphineSerious - Use Alternative (1)isocarboxazid increases toxicity of buprenorphine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.buprenorphine buccalSerious - Use Alternative (1)isocarboxazid increases toxicity of buprenorphine buccal by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.buprenorphine subdermal implantMonitor Closely (1)isocarboxazid, buprenorphine subdermal implant. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine, long-acting injectionMonitor Closely (1)isocarboxazid, buprenorphine, long-acting injection. Either increases toxicity of the other by serotonin levels. Modify Therapy/Monitor Closely. Concomitant use could result in life-threatening serotonin syndrome or opioid toxicity (eg, respiratory depression, coma). Buprenorphine long-acting injection is not recommended for patients taking MAOIs or within 14 days of stopping such treatment.bupropionContraindicated (1)isocarboxazid and bupropion both increase dopaminergic effects. Contraindicated. Bupropion inhibits reuptake of dopamine and norepinephrine (NE), and MAOIs decrease metabolism of dopamine and NE; coadministration increases risk for hypertensive reactions; allow at least 14 days between discontinuation of MAOI and initiating bupropionbuspironeContraindicated (2)isocarboxazid and buspirone both increase serotonin levels. Contraindicated. isocarboxazid, buspirone. Mechanism: pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.butabarbitalSerious - Use Alternative (1)isocarboxazid, butabarbital. Other (see comment). Contraindicated. Comment: CNS depressants such as barbiturates should not be used in combination with isocarboxazid.Minor (1)isocarboxazid increases levels of butabarbital by decreasing metabolism. Minor/Significance Unknown. Theoretical interaction.butalbitalSerious - Use Alternative (1)isocarboxazid, butalbital. Other (see comment). Contraindicated. Comment: CNS depressants such as barbiturates should not be used in combination with isocarboxazid.Minor (1)isocarboxazid increases levels of butalbital by decreasing metabolism. Minor/Significance Unknown. Theoretical interaction.butorphanolSerious - Use Alternative (1)isocarboxazid increases toxicity of butorphanol by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.caffeineContraindicated (1)isocarboxazid increases effects of caffeine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.captoprilMonitor Closely (1)isocarboxazid, captopril. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood pressure. Monitor blood pressure.carbamazepineContraindicated (1)carbamazepine increases toxicity of isocarboxazid by unknown mechanism. Contraindicated. D/C MAO inhibitor 2 weeks before.carbinoxamineSerious - Use Alternative (1)isocarboxazid increases effects of carbinoxamine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .celandineMinor (1)celandine increases effects of isocarboxazid by pharmacodynamic synergism. Minor/Significance Unknown. Based on animal studies.cetirizineSerious - Use Alternative (1)isocarboxazid increases effects of cetirizine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .chlorpheniramineSerious - Use Alternative (1)isocarboxazid increases effects of chlorpheniramine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .chlorpropamideMonitor Closely (1)isocarboxazid increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor.chlorthalidoneSerious - Use Alternative (1)isocarboxazid, chlorthalidone. Other (see comment). Contraindicated. Comment: Additive hypotensive effects may be seen when MAOI's are combined with antihypertensives.citalopramContraindicated (1)isocarboxazid and citalopram both increase serotonin levels. Contraindicated. At least 2 weeks should elapse between discontinuation of MAOI therapy and the start of citalopram therapy, and at least 2 weeks between discontinuation of citalopram therapy and commencement of MAOI therapy.clemastineSerious - Use Alternative (1)isocarboxazid increases effects of clemastine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .clomipramineContraindicated (1)isocarboxazid and clomipramine both increase serotonin levels. Contraindicated.cocaine topicalSerious - Use Alternative (1)isocarboxazid and cocaine topical both increase serotonin levels. Contraindicated.codeineSerious - Use Alternative (1)isocarboxazid increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.cordycepsMinor (1)cordyceps increases effects of isocarboxazid by pharmacodynamic synergism. Minor/Significance Unknown.cyclobenzaprineContraindicated (1)isocarboxazid and cyclobenzaprine both increase serotonin levels. Contraindicated. Do not coadminister cyclobenzaprine with MAOIs or within 14 days of discontinuing an MAOIcyproheptadineContraindicated (1)isocarboxazid, cyproheptadine. Other (see comment). Contraindicated. Comment: MAO inhibitors may prolong and intensify the anticholinergic effects of antihistamines. Cyproheptadine may diminish the serotonergic effect of MAO inhibitors.desfluraneSerious - Use Alternative (1)isocarboxazid increases levels of desflurane by pharmacodynamic synergism. Avoid or Use Alternate Drug.desipramineContraindicated (1)isocarboxazid and desipramine both increase serotonin levels. Contraindicated.desloratadineSerious - Use Alternative (1)isocarboxazid increases effects of desloratadine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .desvenlafaxineContraindicated (1)isocarboxazid and desvenlafaxine both increase serotonin levels. Contraindicated. At least 14 days should elapse between discontinuation of MAOIs and initiation of treatment with a serotonergic drugdeutetrabenazineContraindicated (1)isocarboxazid, deutetrabenazine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Deutetrabenazine should not be used in combination with an MAOI, or within 14 days of discontinuing therapy with an MAOI.dexfenfluramineContraindicated (1)isocarboxazid increases effects of dexfenfluramine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.Serious - Use Alternative (1)isocarboxazid and dexfenfluramine both increase serotonin levels. Avoid or Use Alternate Drug.dexmethylphenidateContraindicated (1)isocarboxazid increases effects of dexmethylphenidate by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.dextroamphetamineContraindicated (1)isocarboxazid increases effects of dextroamphetamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.Serious - Use Alternative (1)isocarboxazid and dextroamphetamine both increase serotonin levels. Avoid or Use Alternate Drug.dextroamphetamine transdermalContraindicated (1)isocarboxazid increases effects of dextroamphetamine transdermal by decreasing metabolism. Contraindicated. MAOIs slows amphetamine metabolism, increasing amphetamine?s effect on norepinephrine release and other monoamines from adrenergic nerve endings causing signs of hypertensive crisis. Do not administer dextroamphetamine during or within 14 days following MAOI administration.dextromethorphanContraindicated (1)isocarboxazid and dextromethorphan both increase serotonin levels. Contraindicated.dextromoramideSerious - Use Alternative (1)isocarboxazid increases toxicity of dextromoramide by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.diamorphineSerious - Use Alternative (1)isocarboxazid increases toxicity of diamorphine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.diazepam intranasalMonitor Closely (1)diazepam intranasal, isocarboxazid. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diethylpropionContraindicated (1)isocarboxazid increases effects of diethylpropion by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.difenoxin hclMonitor Closely (1)difenoxin hcl, isocarboxazid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.Serious - Use Alternative (1)isocarboxazid increases toxicity of difenoxin hcl by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.dihydroergotamineSerious - Use Alternative (1)isocarboxazid and dihydroergotamine both increase serotonin levels. Avoid or Use Alternate Drug.dihydroergotamine intranasalSerious - Use Alternative (1)isocarboxazid and dihydroergotamine intranasal both increase serotonin levels. Avoid or Use Alternate Drug.diphenhydramineSerious - Use Alternative (1)isocarboxazid increases effects of diphenhydramine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .diphenoxylate hclMonitor Closely (1)diphenoxylate hcl, isocarboxazid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.Serious - Use Alternative (1)isocarboxazid increases toxicity of diphenoxylate hcl by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.dipipanoneSerious - Use Alternative (1)isocarboxazid increases toxicity of dipipanone by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.disulfiramMinor (1)disulfiram, isocarboxazid. Mechanism: unknown. Minor/Significance Unknown. Risk of delirium (case report).dobutamineContraindicated (1)isocarboxazid increases effects of dobutamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.dolasetronSerious - Use Alternative (1)dolasetron, isocarboxazid. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug.donepezil transdermalMonitor Closely (1)donepezil transdermal, isocarboxazid. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.dopamineContraindicated (1)isocarboxazid increases effects of dopamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.dopexamineSerious - Use Alternative (1)isocarboxazid increases effects of dopexamine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.dosulepinContraindicated (1)isocarboxazid and dosulepin both increase serotonin levels. Contraindicated.doxapramSerious - Use Alternative (1)doxapram increases effects of isocarboxazid by pharmacodynamic synergism. Avoid or Use Alternate Drug. Additive pressor effect.doxepinContraindicated (1)isocarboxazid and doxepin both increase serotonin levels. Contraindicated.doxepin creamSerious - Use Alternative (1)isocarboxazid increases levels of doxepin cream by pharmacodynamic synergism. Contraindicated. D/C MAO inhibitor 2 weeks before.doxylamineSerious - Use Alternative (1)isocarboxazid increases effects of doxylamine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .duloxetineContraindicated (1)isocarboxazid and duloxetine both increase serotonin levels. Contraindicated.eletriptanSerious - Use Alternative (2)eletriptan and isocarboxazid both increase serotonin levels. Avoid or Use Alternate Drug. isocarboxazid increases levels of eletriptan by decreasing metabolism. Contraindicated.entacaponeContraindicated (1)entacapone, isocarboxazid. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Both nonselective MAO inhibitors and entacapone inhibit catecholamine metabolism, leading to increased levels of catecholamines. Potential for dangerously high HR or BP.ephedrineContraindicated (1)isocarboxazid increases effects of ephedrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.epinephrineContraindicated (1)isocarboxazid increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.epinephrine inhaledContraindicated (1)isocarboxazid and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Coadministration of epinephrine inhaled with MAOIs or within 2 weeks after discontinuing an MAOI is contraindicated.epinephrine racemicSerious - Use Alternative (1)isocarboxazid increases effects of epinephrine racemic by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.ergotamineSerious - Use Alternative (1)isocarboxazid and ergotamine both increase serotonin levels. Avoid or Use Alternate Drug.escitalopramContraindicated (1)isocarboxazid and escitalopram both increase serotonin levels. Contraindicated.esketamine intranasalMonitor Closely (1)esketamine intranasal, isocarboxazid. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with MAO-Is. .etomidateMonitor Closely (1)isocarboxazid increases levels of etomidate by pharmacodynamic synergism. Use Caution/Monitor.fenfluramineContraindicated (2)isocarboxazid increases effects of fenfluramine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode. fenfluramine, isocarboxazid. Either increases effects of the other by serotonin levels. Contraindicated. Coadministration with drugs that increase serotonin may increase the risk of serotonin syndrome. Do not use concomitantly or within 14 days of MAOIs.Serious - Use Alternative (1)isocarboxazid and fenfluramine both increase serotonin levels. Avoid or Use Alternate Drug.fentanylContraindicated (1)isocarboxazid increases toxicity of fentanyl by Other (see comment). Contraindicated. Comment: Avoid fentanyl in patients who require concomitant administration MAOIs, or within 14 days of stopping an MAOI. Severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.fentanyl intranasalContraindicated (1)isocarboxazid increases toxicity of fentanyl intranasal by Other (see comment). Contraindicated. Comment: Avoid fentanyl in patients who require concomitant administration MAOIs, or within 14 days of stopping an MAOI. Severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.fentanyl transdermalContraindicated (1)isocarboxazid increases toxicity of fentanyl transdermal by Other (see comment). Contraindicated. Comment: Avoid fentanyl in patients who require concomitant administration MAOIs, or within 14 days of stopping an MAOI. Severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.fentanyl transmucosalContraindicated (1)isocarboxazid increases toxicity of fentanyl transmucosal by Other (see comment). Contraindicated. Comment: Avoid fentanyl in patients who require concomitant administration MAOIs, or within 14 days of stopping an MAOI. Severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.fexofenadineSerious - Use Alternative (1)isocarboxazid increases effects of fexofenadine by Other (see comment). Avoid or Use Alternate Drug. Comment: Isocarboxazid should not be administered in combination with antihistamines because of potential additive CNS depressant effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines. .fluoxetineContraindicated (1)isocarboxazid and fluoxetine both increase serotonin levels. Contraindicated.fluvoxamineContraindicated (1)fluvoxamine and isocarboxazid both increase serotonin levels. Contraindicated.formoterolSerious - Use Alternative (1)isocarboxazid increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.frovatriptanSerious - Use Alternative (2)frovatriptan and isocarboxazid both increase serotonin levels. Avoid or Use