and/or prolonged drug effect.mirtazapinebrexanolone, mirtazapine. Either increases toxicity of the other by sedation. Use Caution/Monitor.molindonebrexanolone, molindone. Either increases toxicity of the other by sedation. Use Caution/Monitor.morphinebrexanolone, morphine. Either increases toxicity of the other by sedation. Use Caution/Monitor.nalbuphinebrexanolone, nalbuphine. Either increases toxicity of the other by sedation. Use Caution/Monitor.nitric oxide gasbrexanolone, nitric oxide gas. Either increases toxicity of the other by sedation. Use Caution/Monitor.olanzapinebrexanolone, olanzapine. Either increases toxicity of the other by sedation. Use Caution/Monitor.oliceridinebrexanolone, oliceridine. Either increases toxicity of the other by sedation. Use Caution/Monitor.opium tincturebrexanolone, opium tincture. Either increases toxicity of the other by sedation. Use Caution/Monitor.orphenadrinebrexanolone, orphenadrine. Either increases toxicity of the other by sedation. Use Caution/Monitor.oxazepambrexanolone, oxazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.oxycodonebrexanolone, oxycodone. Either increases toxicity of the other by sedation. Use Caution/Monitor.oxymorphonebrexanolone, oxymorphone. Either increases toxicity of the other by sedation. Use Caution/Monitor.paliperidonebrexanolone, paliperidone. Either increases toxicity of the other by sedation. Use Caution/Monitor.pentazocinebrexanolone, pentazocine. Either increases toxicity of the other by sedation. Use Caution/Monitor.pentobarbitalbrexanolone, pentobarbital. Either increases toxicity of the other by sedation. Use Caution/Monitor.perampanelbrexanolone, perampanel. Either increases toxicity of the other by sedation. Use Caution/Monitor.perphenazinebrexanolone, perphenazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.pheniraminebrexanolone, pheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.phenobarbitalbrexanolone, phenobarbital. Either increases toxicity of the other by sedation. Use Caution/Monitor.phenytoinbrexanolone, phenytoin. Either increases toxicity of the other by sedation. Use Caution/Monitor.pimavanserinbrexanolone, pimavanserin. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.pimozidebrexanolone, pimozide. Either increases toxicity of the other by sedation. Use Caution/Monitor.pomalidomidebrexanolone, pomalidomide. Either increases toxicity of the other by sedation. Use Caution/Monitor.pregabalinbrexanolone, pregabalin. Either increases toxicity of the other by sedation. Use Caution/Monitor.pregabalin, brexanolone. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidonebrexanolone, primidone. Either increases toxicity of the other by sedation. Use Caution/Monitor.prochlorperazinebrexanolone, prochlorperazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.promazinebrexanolone, promazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.promethazinebrexanolone, promethazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.quazepambrexanolone, quazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.quetiapinebrexanolone, quetiapine. Either increases toxicity of the other by sedation. Use Caution/Monitor.ramelteonbrexanolone, ramelteon. Either increases toxicity of the other by sedation. Use Caution/Monitor.remifentanilbrexanolone, remifentanil. Either increases toxicity of the other by sedation. Use Caution/Monitor.remimazolamremimazolam, brexanolone. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.risperidonebrexanolone, risperidone. Either increases toxicity of the other by sedation. Use Caution/Monitor.scopolaminebrexanolone, scopolamine. Either increases toxicity of the other by sedation. Use Caution/Monitor.secobarbitalbrexanolone, secobarbital. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.sevofluranebrexanolone, sevoflurane. Either increases toxicity of the other by sedation. Use Caution/Monitor.sodium oxybatebrexanolone, sodium oxybate. Either increases toxicity of the other by sedation. Use Caution/Monitor.stiripentolbrexanolone, stiripentol. Either increases toxicity of the other by sedation. Use Caution/Monitor.sufentanilbrexanolone, sufentanil. Either increases toxicity of the other by sedation. Use Caution/Monitor.sufentanil SLbrexanolone, sufentanil SL. Either increases toxicity of the other by sedation. Use Caution/Monitor.sulpiridebrexanolone, sulpiride. Either increases toxicity of the other by sedation. Use Caution/Monitor.suvorexantbrexanolone, suvorexant. Either increases toxicity of the other by sedation. Use Caution/Monitor.tapentadolbrexanolone, tapentadol. Either increases toxicity of the other by sedation. Use Caution/Monitor.tasimelteonbrexanolone, tasimelteon. Either increases toxicity of the other by sedation. Use Caution/Monitor.temazepambrexanolone, temazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.tetrabenazinebrexanolone, tetrabenazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.thalidomidebrexanolone, thalidomide. Either increases toxicity of the other by sedation. Use Caution/Monitor.thioridazinebrexanolone, thioridazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.thiothixenebrexanolone, thiothixene. Either increases toxicity of the other by sedation. Use Caution/Monitor.tiagabinebrexanolone, tiagabine. Either increases levels of the other by sedation. Use Caution/Monitor.tizanidinebrexanolone, tizanidine. Either increases toxicity of the other by sedation. Use Caution/Monitor.topiramatebrexanolone, topiramate. Either increases toxicity of the other by sedation. Use Caution/Monitor.tramadolbrexanolone, tramadol. Either increases toxicity of the other by sedation. Use Caution/Monitor.triazolambrexanolone, triazolam. Either increases toxicity of the other by sedation. Use Caution/Monitor.trifluoperazinebrexanolone, trifluoperazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.triprolidinebrexanolone, triprolidine. Either increases toxicity of the other by sedation. Use Caution/Monitor.valerianbrexanolone, valerian. Either increases toxicity of the other by sedation. Use Caution/Monitor.vigabatrinbrexanolone, vigabatrin. Either increases toxicity of the other by sedation. Use Caution/Monitor.zaleplonbrexanolone, zaleplon. Either increases toxicity of the other by sedation. Use Caution/Monitor.ziconotidebrexanolone, ziconotide. Either increases toxicity of the other by sedation. Use Caution/Monitor.ziprasidonebrexanolone, ziprasidone. Either increases toxicity of the other by sedation. Use Caution/Monitor.zolpidembrexanolone, zolpidem. Either increases toxicity of the other by sedation. Use Caution/Monitor.Minor (0)acetaminophen/phenyltoloxamineMonitor Closely (1)brexanolone, acetaminophen/phenyltoloxamine. Either increases toxicity of the other by sedation. Use Caution/Monitor.acrivastineMonitor Closely (2)brexanolone, acrivastine. Either increases toxicity of the other by sedation. Use Caution/Monitor. acrivastine and brexanolone both increase sedation. Use Caution/Monitor.alfentanilMonitor Closely (1)brexanolone, alfentanil. Either increases toxicity of the other by sedation. Use Caution/Monitor.alprazolamMonitor Closely (1)brexanolone, alprazolam. Either increases toxicity of the other by sedation. Use Caution/Monitor.amisulprideMonitor Closely (1)amisulpride and brexanolone both increase sedation. Use Caution/Monitor.amobarbitalMonitor Closely (1)brexanolone, amobarbital. Either increases toxicity of the other by sedation. Use Caution/Monitor.arbaclofenMonitor Closely (1)brexanolone, arbaclofen. Either increases toxicity of the other by sedation. Use Caution/Monitor.aripiprazoleMonitor Closely (1)brexanolone, aripiprazole. Either increases toxicity of the other by sedation. Use Caution/Monitor.asenapineMonitor Closely (1)brexanolone, asenapine. Either increases toxicity of the other by sedation. Use Caution/Monitor.asenapine transdermalMonitor Closely (1)asenapine transdermal and brexanolone both increase sedation. Use Caution/Monitor.avapritinibMonitor Closely (1)avapritinib and brexanolone both increase sedation. Use Caution/Monitor.baclofenMonitor Closely (1)brexanolone, baclofen. Either increases toxicity of the other by sedation. Use Caution/Monitor.benperidolMonitor Closely (1)brexanolone, benperidol. Either increases toxicity of the other by sedation. Use Caution/Monitor.benzhydrocodone/acetaminophenMonitor Closely (1)brexanolone, benzhydrocodone/acetaminophen. Either increases toxicity of the other by sedation. Use Caution/Monitor.brexpiprazoleMonitor Closely (1)brexanolone, brexpiprazole. Either increases toxicity of the other by sedation. Use Caution/Monitor.brimonidineMonitor Closely (1)brimonidine and brexanolone both increase sedation. Use Caution/Monitor.brivaracetamMonitor Closely (1)brexanolone, brivaracetam. Either increases toxicity of the other by sedation. Use Caution/Monitor.brompheniramineMonitor Closely (1)brexanolone, brompheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.buprenorphineMonitor Closely (1)brexanolone, buprenorphine. Either increases toxicity of the other by sedation. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)brexanolone, buprenorphine buccal. Either increases toxicity of the other by sedation. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)brexanolone, buprenorphine subdermal implant. Either increases toxicity of the other by sedation. Use Caution/Monitor.buprenorphine transdermalMonitor Closely (1)brexanolone, buprenorphine transdermal. Either increases toxicity of the other by sedation. Use Caution/Monitor.buprenorphine, long-acting injectionMonitor Closely (1)brexanolone, buprenorphine, long-acting injection. Either increases toxicity of the other by sedation. Use Caution/Monitor.buspironeMonitor Closely (1)brexanolone, buspirone. Either increases toxicity of the other by sedation. Use Caution/Monitor.butabarbitalMonitor Closely (1)brexanolone, butabarbital. Either increases toxicity of the other by sedation. Use Caution/Monitor.butalbitalMonitor Closely (1)brexanolone, butalbital. Either increases toxicity of the other by sedation. Use Caution/Monitor.butorphanolMonitor Closely (1)brexanolone, butorphanol. Either increases toxicity of the other by sedation. Use Caution/Monitor.calcium/magnesium/potassium/sodium oxybatesMonitor Closely (1)brexanolone, calcium/magnesium/potassium/sodium oxybates. Either increases toxicity of the other by sedation. Use Caution/Monitor.carbamazepineMonitor Closely (1)brexanolone, carbamazepine. Either increases toxicity of the other by sedation. Use Caution/Monitor.carbinoxamineMonitor Closely (1)brexanolone, carbinoxamine. Either increases toxicity of the other by sedation. Use Caution/Monitor.cariprazineMonitor Closely (1)brexanolone, cariprazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.carisoprodolMonitor Closely (1)brexanolone, carisoprodol. Either increases toxicity of the other by sedation. Use Caution/Monitor.cenobamateMonitor Closely (1)cenobamate, brexanolone. Either increases effects of the other by sedation. Use Caution/Monitor.chloral hydrateMonitor Closely (1)brexanolone, chloral hydrate. Either increases toxicity of the other by sedation. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)brexanolone, chlordiazepoxide. Either increases toxicity of the other by sedation. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)brexanolone, chlorpheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.chlorpromazineMonitor Closely (1)brexanolone, chlorpromazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.chlorzoxazoneMonitor Closely (1)brexanolone, chlorzoxazone. Either increases toxicity of the other by sedation. Use Caution/Monitor.clemastineMonitor Closely (1)brexanolone, clemastine. Either increases toxicity of the other by sedation. Use Caution/Monitor.clobazamMonitor Closely (1)brexanolone, clobazam. Either increases toxicity of the other by sedation. Use Caution/Monitor.clonazepamMonitor Closely (1)brexanolone, clonazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.clonidineMonitor Closely (1)brexanolone, clonidine. Either increases toxicity of the other by sedation. Use Caution/Monitor.clorazepateMonitor Closely (1)brexanolone, clorazepate. Either increases toxicity of the other by sedation. Use Caution/Monitor.clozapineMonitor Closely (1)brexanolone, clozapine. Either increases toxicity of the other by sedation. Use Caution/Monitor.codeineMonitor Closely (1)brexanolone, codeine. Either increases toxicity of the other by sedation. Use Caution/Monitor.cyclobenzaprineMonitor Closely (1)brexanolone, cyclobenzaprine. Either increases toxicity of the other by sedation. Use Caution/Monitor.cyproheptadineMonitor Closely (1)brexanolone, cyproheptadine. Either increases toxicity of the other by sedation. Use Caution/Monitor.dantroleneMonitor Closely (1)brexanolone, dantrolene. Either increases toxicity of the other by sedation. Use Caution/Monitor.daridorexantMonitor Closely (1)brexanolone and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. desfluraneMonitor Closely (1)brexanolone, desflurane. Either increases toxicity of the other by sedation. Use Caution/Monitor.deutetrabenazineMonitor Closely (1)brexanolone, deutetrabenazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.dexbrompheniramineMonitor Closely (1)brexanolone, dexbrompheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.dexchlorpheniramineMonitor Closely (1)brexanolone, dexchlorpheniramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.diazepamMonitor Closely (1)brexanolone, diazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.diazepam intranasalMonitor Closely (1)diazepam intranasal, brexanolone. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.difelikefalinMonitor Closely (1)difelikefalin and brexanolone both increase sedation. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)brexanolone, dimenhydrinate. Either increases toxicity of the other by sedation. Use Caution/Monitor.diphenhydramineMonitor Closely (1)brexanolone, diphenhydramine. Either increases toxicity of the other by sedation. Use Caution/Monitor.diphenoxylate hclMonitor Closely (1)brexanolone, diphenoxylate hcl. Either increases toxicity of the other by sedation. Use Caution/Monitor.dosulepinMonitor Closely (1)brexanolone, dosulepin. Either increases toxicity of the other by sedation. Use Caution/Monitor.doxylamineMonitor Closely (1)brexanolone, doxylamine. Either increases toxicity of the other by sedation. Use Caution/Monitor.droperidolMonitor Closely (1)brexanolone, droperidol. Either increases toxicity of the other by sedation. Use Caution/Monitor.efavirenzMonitor Closely (1)brexanolone, efavirenz. Either increases toxicity of the other by sedation. Use Caution/Monitor.emedastineMonitor Closely (1)brexanolone, emedastine. Either increases toxicity of the other by sedation. Use Caution/Monitor.esketamine intranasalMonitor Closely (1)brexanolone, esketamine intranasal. Either increases toxicity of the other by sedation. Use Caution/Monitor.estazolamMonitor Closely (1)brexanolone, estazolam. Either increases toxicity of the other by sedation. Use Caution/Monitor.eszopicloneMonitor Closely (1)brexanolone, eszopiclone. Either increases toxicity of the other by sedation. Use Caution/Monitor.ethanolMonitor Closely (1)brexanolone, ethanol. Either increases toxicity of the other by sedation. Use Caution/Monitor.ethosuximideMonitor Closely (1)brexanolone, ethosuximide. Either increases toxicity of the other by sedation. Use Caution/Monitor.ethotoinMonitor Closely (1)brexanolone, ethotoin. Either increases toxicity of the other by sedation. Use Caution/Monitor.ezogabineMonitor Closely (1)brexanolone, ezogabine. Either increases toxicity of the other by sedation. Use Caution/Monitor.felbamateMonitor Closely (1)brexanolone, felbamate. Either increases toxicity of the other by sedation. Use Caution/Monitor.fenfluramineMonitor Closely (1)fenfluramine, brexanolone. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome.fentanylMonitor Closely (1)brexanolone, fentanyl. Either increases toxicity of the other by sedation. Use Caution/Monitor.fentanyl intranasalMonitor Closely (1)brexanolone, fentanyl intranasal. Either increases toxicity of the other by sedation. Use Caution/Monitor.fentanyl transdermalMonitor Closely (1)brexanolone, fentanyl transdermal. Either increases toxicity of the other by sedation. Use Caution/Monitor.fentanyl transmucosalMonitor Closely (1)brexanolone, fentanyl transmucosal. Either increases toxicity of the other by sedation. Use Caution/Monitor.flibanserinMonitor Closely (1)brexanolone, flibanserin. Either increases toxicity of the other by sedation. Use Caution/Monitor.fluphenazineMonitor Closely (1)brexanolone, fluphenazine. Either increases toxicity of the other by sedation. Use Caution/Monitor.flurazepamMonitor Closely (1)brexanolone, flurazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.fosphenytoinMonitor Closely (1)brexanolone, fosphenytoin. Either increases toxicity of the other by sedation. Use Caution/Monitor.gabapentinMonitor Closely (2)brexanolone, gabapentin. Either increases toxicity of the other by sedation. Use Caution/Monitor. gabapentin, brexanolone. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.gabapentin enacarbilMonitor Closely (2)brexanolone, gabapentin enacarbil. Either increases toxicity of the other by sedation. Use Caution/Monitor. gabapentin enacarbil, brexanolone. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.ganaxoloneMonitor Closely (1)brexanolone and ganaxolone both increase sedation. Use Caution/Monitor.guanfacineMonitor Closely (1)brexanolone, guanfacine. Either increases toxicity of the other by sedation. Use Caution/Monitor.haloperidolMonitor Closely (1)brexanolone, haloperidol. Either increases toxicity of the other by sedation. Use Caution/Monitor.hydrocodoneMonitor Closely (1)brexanolone, hydrocodone. Either increases toxicity of the other by sedation. Use Caution/Monitor.hydromorphoneMonitor Closely