solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.sufentanilsufentanil increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.tapentadoltapentadol increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.temazepamtemazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.terbutalineterbutaline and dexmethylphenidate both decrease sedation. Use Caution/Monitor.terbutaline and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.thioridazinethioridazine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.thioridazine, dexmethylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.thiothixenethiothixene increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.topiramatetopiramate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.tramadoltramadol increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodonetrazodone increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triazolamtriazolam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triclofostriclofos increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trifluoperazinetrifluoperazine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trifluoperazine, dexmethylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only.trimipraminetrimipramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.triprolidinetriprolidine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.xylometazolinedexmethylphenidate and xylometazoline both decrease sedation. Use Caution/Monitor.dexmethylphenidate and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.yohimbinedexmethylphenidate and yohimbine both decrease sedation. Use Caution/Monitor.dexmethylphenidate and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.ziconotideziconotide increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ziprasidoneziprasidone increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (61)acetazolamidedexmethylphenidate increases effects of acetazolamide by decreasing metabolism. Minor/Significance Unknown.amantadineamantadine, dexmethylphenidate. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Potential for additive CNS stimulation.American ginsengAmerican ginseng increases effects of dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.amitriptylinedexmethylphenidate increases effects of amitriptyline by decreasing metabolism. Minor/Significance Unknown.amoxapinedexmethylphenidate increases effects of amoxapine by decreasing metabolism. Minor/Significance Unknown.antithrombin alfadexmethylphenidate increases effects of antithrombin alfa by decreasing metabolism. Minor/Significance Unknown.antithrombin IIIdexmethylphenidate increases effects of antithrombin III by decreasing metabolism. Minor/Significance Unknown.argatrobandexmethylphenidate increases effects of argatroban by decreasing metabolism. Minor/Significance Unknown.bemiparindexmethylphenidate increases effects of bemiparin by decreasing metabolism. Minor/Significance Unknown.bivalirudindexmethylphenidate increases effects of bivalirudin by decreasing metabolism. Minor/Significance Unknown.carbamazepinedexmethylphenidate increases effects of carbamazepine by decreasing metabolism. Minor/Significance Unknown.clomipraminedexmethylphenidate increases effects of clomipramine by decreasing metabolism. Minor/Significance Unknown.clonazepamdexmethylphenidate increases effects of clonazepam by decreasing metabolism. Minor/Significance Unknown.dalteparindexmethylphenidate increases effects of dalteparin by decreasing metabolism. Minor/Significance Unknown.desipraminedexmethylphenidate increases effects of desipramine by decreasing metabolism. Minor/Significance Unknown.desmopressindesmopressin increases effects of dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.diazepamdexmethylphenidate increases effects of diazepam by decreasing metabolism. Minor/Significance Unknown.dosulepindexmethylphenidate increases effects of dosulepin by decreasing metabolism. Minor/Significance Unknown.doxepindexmethylphenidate increases effects of doxepin by decreasing metabolism. Minor/Significance Unknown.duloxetinedexmethylphenidate increases effects of duloxetine by decreasing metabolism. Minor/Significance Unknown.enoxaparindexmethylphenidate increases effects of enoxaparin by decreasing metabolism. Minor/Significance Unknown.ethosuximidedexmethylphenidate increases effects of ethosuximide by decreasing metabolism. Minor/Significance Unknown.eucalyptuseucalyptus increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.felbamatedexmethylphenidate increases effects of felbamate by decreasing metabolism. Minor/Significance Unknown.fluoxetinedexmethylphenidate increases effects of fluoxetine by decreasing metabolism. Minor/Significance Unknown.fondaparinuxdexmethylphenidate increases effects of fondaparinux by decreasing metabolism. Minor/Significance Unknown.fosphenytoindexmethylphenidate increases effects of fosphenytoin by decreasing metabolism. Minor/Significance Unknown.gabapentindexmethylphenidate increases effects of gabapentin by decreasing metabolism. Minor/Significance Unknown.gabapentin enacarbildexmethylphenidate increases effects of gabapentin enacarbil by decreasing metabolism. Minor/Significance Unknown.guaranaguarana increases effects of dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.heparindexmethylphenidate increases effects of heparin by decreasing metabolism. Minor/Significance Unknown.imipraminedexmethylphenidate increases effects of imipramine by decreasing metabolism. Minor/Significance Unknown.lacosamidedexmethylphenidate increases effects of lacosamide by decreasing metabolism. Minor/Significance Unknown.lamotriginedexmethylphenidate increases effects of lamotrigine by decreasing metabolism. Minor/Significance Unknown.levetiracetamdexmethylphenidate increases effects of levetiracetam by decreasing metabolism. Minor/Significance Unknown.lofepraminedexmethylphenidate increases effects of lofepramine by decreasing metabolism. Minor/Significance Unknown.lorazepamdexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor/Significance Unknown.maprotilinedexmethylphenidate increases effects of maprotiline by decreasing metabolism. Minor/Significance Unknown.methsuximidedexmethylphenidate increases effects of methsuximide by decreasing metabolism. Minor/Significance Unknown.milnaciprandexmethylphenidate increases effects of milnacipran by decreasing metabolism. Minor/Significance Unknown.nefazodonedexmethylphenidate increases effects of nefazodone by decreasing metabolism. Minor/Significance Unknown.nortriptylinedexmethylphenidate increases effects of nortriptyline by decreasing metabolism. Minor/Significance Unknown.oxcarbazepinedexmethylphenidate increases effects of oxcarbazepine by decreasing metabolism. Minor/Significance Unknown.paroxetinedexmethylphenidate increases effects of paroxetine by decreasing metabolism. Minor/Significance Unknown.phenindionedexmethylphenidate increases effects of phenindione by decreasing metabolism. Minor/Significance Unknown.phenobarbitaldexmethylphenidate increases effects of phenobarbital by decreasing metabolism. Minor/Significance Unknown.phenytoindexmethylphenidate increases effects of phenytoin by decreasing metabolism. Minor/Significance Unknown.primidonedexmethylphenidate increases effects of primidone by decreasing metabolism. Minor/Significance Unknown.protaminedexmethylphenidate increases effects of protamine by decreasing metabolism. Minor/Significance Unknown.protriptylinedexmethylphenidate increases effects of protriptyline by decreasing metabolism. Minor/Significance Unknown.rufinamidedexmethylphenidate increases effects of rufinamide by decreasing metabolism. Minor/Significance Unknown.sagesage increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.sertralinedexmethylphenidate increases effects of sertraline by decreasing metabolism. Minor/Significance Unknown.tiagabinedexmethylphenidate increases effects of tiagabine by decreasing metabolism. Minor/Significance Unknown.topiramatedexmethylphenidate increases effects of topiramate by decreasing metabolism. Minor/Significance Unknown.trazodonedexmethylphenidate increases effects of trazodone by decreasing metabolism. Minor/Significance Unknown.trimipraminedexmethylphenidate increases effects of trimipramine by decreasing metabolism. Minor/Significance Unknown.valproic aciddexmethylphenidate increases effects of valproic acid by decreasing metabolism. Minor/Significance Unknown.venlafaxinedexmethylphenidate increases effects of venlafaxine by decreasing metabolism. Minor/Significance Unknown.yerba mateyerba mate increases effects of dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.zonisamidedexmethylphenidate increases effects of zonisamide by decreasing metabolism. Minor/Significance Unknown.acetazolamideMinor (1)dexmethylphenidate increases effects of acetazolamide by decreasing metabolism. Minor/Significance Unknown.albuterolMonitor Closely (2)albuterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor. albuterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilMonitor Closely (1)alfentanil increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamMonitor Closely (1)alprazolam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amantadineMinor (1)amantadine, dexmethylphenidate. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Potential for additive CNS stimulation.American ginsengMinor (1)American ginseng increases effects of dexmethylphenidate by pharmacodynamic synergism. Minor/Significance Unknown.amitriptylineMonitor Closely (1)amitriptyline increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amitriptyline, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of amitriptyline by decreasing metabolism. Minor/Significance Unknown.amobarbitalMonitor Closely (1)amobarbital increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineMonitor Closely (1)amoxapine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)amoxapine, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of amoxapine by decreasing metabolism. Minor/Significance Unknown.antithrombin alfaMinor (1)dexmethylphenidate increases effects of antithrombin alfa by decreasing metabolism. Minor/Significance Unknown.antithrombin IIIMinor (1)dexmethylphenidate increases effects of antithrombin III by decreasing metabolism. Minor/Significance Unknown.arformoterolMonitor Closely (2)arformoterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor. arformoterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.argatrobanMinor (1)dexmethylphenidate increases effects of argatroban by decreasing metabolism. Minor/Significance Unknown.aripiprazoleMonitor Closely (1)aripiprazole increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilMonitor Closely (1)armodafinil and dexmethylphenidate both decrease sedation. Use Caution/Monitor.azelastineMonitor Closely (1)azelastine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.belladonna and opiumMonitor Closely (1)belladonna and opium increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.bemiparinMinor (1)dexmethylphenidate increases effects of bemiparin by decreasing metabolism. Minor/Significance Unknown.benperidolMonitor Closely (1)benperidol increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzhydrocodone/acetaminophenSerious - Use Alternative (1)benzhydrocodone/acetaminophen, dexmethylphenidate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.benzphetamineMonitor Closely (2)dexmethylphenidate and benzphetamine both decrease sedation. Use Caution/Monitor. benzphetamine and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.bivalirudinMinor (1)dexmethylphenidate increases effects of bivalirudin by decreasing metabolism. Minor/Significance Unknown.bromocriptineMonitor Closely (1)bromocriptine, dexmethylphenidate. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Hypertension, V tach.brompheniramineMonitor Closely (1)brompheniramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.buprenorphine buccalMonitor Closely (1)buprenorphine buccal increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.buprenorphine subdermal implantMonitor Closely (1)dexmethylphenidate, buprenorphine subdermal implant. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine, long-acting injectionMonitor Closely (1)dexmethylphenidate, buprenorphine, long-acting injection. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.butabarbitalMonitor Closely (1)butabarbital increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalMonitor Closely (1)butalbital increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolMonitor Closely (1)butorphanol increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cabergolineSerious - Use Alternative (1)cabergoline, dexmethylphenidate. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension.caffeineMonitor Closely (1)caffeine and dexmethylphenidate both decrease sedation. Use Caution/Monitor.captoprilMonitor Closely (1)dexmethylphenidate decreases effects of captopril by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effect of captopril.carbamazepineMinor (1)dexmethylphenidate increases effects of carbamazepine by decreasing metabolism. Minor/Significance Unknown.carbinoxamineMonitor Closely (1)carbinoxamine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydrateMonitor Closely (1)chloral hydrate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxideMonitor Closely (1)chlordiazepoxide increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpheniramineMonitor Closely (1)chlorpheniramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazineMonitor Closely (2)chlorpromazine, dexmethylphenidate. Mechanism: unknown. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. chlorpromazine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cimetidineMonitor Closely (1)cimetidine will increase the level or effect of dexmethylphenidate by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Applies only to extended release formulationcinnarizineMonitor Closely (1)cinnarizine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.citalopramMonitor Closely (1)dexmethylphenidate increases effects of citalopram by decreasing metabolism. Use Caution/Monitor. Potential risk for serotonin syndrome or neuroleptic malignant syndrome-like reactions, caution should be observed during coadministration.clemastineMonitor Closely (1)clemastine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineMonitor Closely (1)clomipramine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)clomipramine, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)dexmethylphenidate increases effects of clomipramine by decreasing metabolism. Minor/Significance Unknown.clonazepamMonitor Closely (1)clonazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)dexmethylphenidate increases effects of clonazepam by decreasing metabolism. Minor/Significance Unknown.clonidineMonitor Closely (1)dexmethylphenidate increases toxicity of clonidine by unknown mechanism. Use Caution/Monitor.clorazepateMonitor Closely (1)clorazepate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineMonitor Closely (1)clozapine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.codeineMonitor Closely (1)codeine increases and dexmethylphenidate