the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.albuterollofexidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and lofexidine both increase QTc interval. Use Caution/Monitor.alfentanilalfentanil and lofexidine both increase sedation. Use Caution/Monitor.alfuzosinlofexidine and alfuzosin both increase QTc interval. Use Caution/Monitor.alprazolamalprazolam and lofexidine both increase sedation. Use Caution/Monitor.amiodaroneamiodarone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.amitriptylineamitriptyline and lofexidine both increase sedation. Use Caution/Monitor.amitriptyline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.amobarbitalamobarbital and lofexidine both increase sedation. Use Caution/Monitor.amoxapineamoxapine and lofexidine both increase sedation. Use Caution/Monitor.amoxapine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.anagrelideanagrelide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.arformoterollofexidine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and lofexidine both increase QTc interval. Use Caution/Monitor.aripiprazolearipiprazole and lofexidine both increase sedation. Use Caution/Monitor.aripiprazole and lofexidine both increase QTc interval. Use Caution/Monitor.armodafinillofexidine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arsenic trioxidearsenic trioxide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.artemetherartemether and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.asenapineasenapine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.asenapine transdermalasenapine transdermal and lofexidine both increase QTc interval. Use Caution/Monitor.atomoxetineatomoxetine and lofexidine both increase QTc interval. Use Caution/Monitor.azelastineazelastine and lofexidine both increase sedation. Use Caution/Monitor.azithromycinazithromycin increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.baclofenbaclofen and lofexidine both increase sedation. Use Caution/Monitor.belladonna and opiumbelladonna and opium and lofexidine both increase sedation. Use Caution/Monitor.benperidolbenperidol and lofexidine both increase sedation. Use Caution/Monitor.benzphetaminelofexidine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.brompheniraminebrompheniramine and lofexidine both increase sedation. Use Caution/Monitor.buprenorphinebuprenorphine and lofexidine both increase sedation. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal and lofexidine both increase sedation. Use Caution/Monitor.bupropionbupropion will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.butabarbitalbutabarbital and lofexidine both increase sedation. Use Caution/Monitor.butalbitalbutalbital and lofexidine both increase sedation. Use Caution/Monitor.butorphanolbutorphanol and lofexidine both increase sedation. Use Caution/Monitor.caffeinelofexidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine and lofexidine both increase sedation. Use Caution/Monitor.carisoprodolcarisoprodol and lofexidine both increase sedation. Use Caution/Monitor.chloral hydratechloral hydrate and lofexidine both increase sedation. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide and lofexidine both increase sedation. Use Caution/Monitor.chloroquinechloroquine increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.chlorpheniraminechlorpheniramine and lofexidine both increase sedation. Use Caution/Monitor.chlorpromazinechlorpromazine and lofexidine both increase sedation. Use Caution/Monitor.chlorpropamidechlorpropamide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.chlorzoxazonechlorzoxazone and lofexidine both increase sedation. Use Caution/Monitor.cinacalcetcinacalcet will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.cinnarizinecinnarizine and lofexidine both increase sedation. Use Caution/Monitor.citalopramcitalopram and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.clemastineclemastine and lofexidine both increase sedation. Use Caution/Monitor.clofazimineclofazimine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.clomipramineclomipramine and lofexidine both increase sedation. Use Caution/Monitor.clomipramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.clonazepamclonazepam and lofexidine both increase sedation. Use Caution/Monitor.clorazepateclorazepate and lofexidine both increase sedation. Use Caution/Monitor.clozapineclozapine and lofexidine both increase sedation. Use Caution/Monitor.cocaine topicalcocaine topical will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.codeinecodeine and lofexidine both increase sedation. Use Caution/Monitor.cyclizinecyclizine and lofexidine both increase sedation. Use Caution/Monitor.cyclobenzaprinecyclobenzaprine and lofexidine both increase sedation. Use Caution/Monitor.cyproheptadinecyproheptadine and lofexidine both increase sedation. Use Caution/Monitor.dantrolenedantrolene and lofexidine both increase sedation. Use Caution/Monitor.darunavirdarunavir will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.desfluranedesflurane and lofexidine both increase sedation. Use Caution/Monitor.desipraminedesipramine and lofexidine both increase sedation. Use Caution/Monitor.desipramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.deutetrabenazinedeutetrabenazine and lofexidine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniraminedexchlorpheniramine and lofexidine both increase sedation. Use Caution/Monitor.dexfenfluraminelofexidine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmedetomidinedexmedetomidine and lofexidine both increase sedation. Use Caution/Monitor.dexmethylphenidatelofexidine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextroamphetaminelofexidine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dextromoramidedextromoramide and lofexidine both increase sedation. Use Caution/Monitor.diamorphinediamorphine and lofexidine both increase sedation. Use Caution/Monitor.diazepamdiazepam and lofexidine both increase sedation. Use Caution/Monitor.diethylpropionlofexidine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.difenoxin hcldifenoxin hcl and lofexidine both increase sedation. Use Caution/Monitor.dimenhydrinatedimenhydrinate and lofexidine both increase sedation. Use Caution/Monitor.diphenhydraminediphenhydramine and lofexidine both increase sedation. Use Caution/Monitor.diphenoxylate hcldiphenoxylate hcl and lofexidine both increase sedation. Use Caution/Monitor.dipipanonedipipanone and lofexidine both increase sedation. Use Caution/Monitor.disopyramidedisopyramide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.dobutaminelofexidine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dofetilidedofetilide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.dopaminelofexidine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dopexaminelofexidine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.doxepindoxepin and lofexidine both increase sedation. Use Caution/Monitor.doxepin decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. Use Caution/Monitor.doxylaminedoxylamine and lofexidine both increase sedation. Use Caution/Monitor.dronedaronedronedarone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.droperidoldroperidol and lofexidine both increase sedation. Use Caution/Monitor.eliglustateliglustat and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.ephedrinelofexidine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrinelofexidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine racemiclofexidine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.escitalopramescitalopram increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.estazolamestazolam and lofexidine both increase sedation. Use Caution/Monitor.ethanolethanol and lofexidine both increase sedation. Use Caution/Monitor.etomidateetomidate and lofexidine both increase sedation. Use Caution/Monitor.fenfluraminelofexidine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluoxetinefluoxetine will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.fluoxetine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.fluphenazinefluphenazine and lofexidine both increase sedation. Use Caution/Monitor.flurazepamflurazepam and lofexidine both increase sedation. Use Caution/Monitor.formoterollofexidine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fostemsavirlofexidine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. gadobenategadobenate and lofexidine both increase QTc interval. Use Caution/Monitor.haloperidolhaloperidol and lofexidine both increase sedation. Use Caution/Monitor.hydromorphonehydromorphone and lofexidine both increase sedation. Use Caution/Monitor.hydroxyzinehydroxyzine and lofexidine both increase sedation. Use Caution/Monitor.ibutilideibutilide and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.iloperidoneiloperidone and lofexidine both increase sedation. Use Caution/Monitor.iloperidone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.imipramineimipramine and lofexidine both increase sedation. Use Caution/Monitor.imipramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.isoproterenollofexidine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketamineketamine and lofexidine both increase sedation. Use Caution/Monitor.ketotifen, ophthalmicketotifen, ophthalmic and lofexidine both increase sedation. Use Caution/Monitor.levalbuterollofexidine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levorphanollevorphanol and lofexidine both increase sedation. Use Caution/Monitor.lisdexamfetaminelofexidine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lithiumlithium and lofexidine both increase QTc interval. Use Caution/Monitor.lofepraminelofepramine and lofexidine both increase sedation. Use Caution/Monitor.lofepramine decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.lopinavirlopinavir and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.loprazolamloprazolam and lofexidine both increase sedation. Use Caution/Monitor.lorazepamlorazepam and lofexidine both increase sedation. Use Caution/Monitor.lorcaserinlorcaserin will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.lormetazepamlormetazepam and lofexidine both increase sedation. Use Caution/Monitor.loxapineloxapine and lofexidine both increase sedation. Use Caution/Monitor.loxapine inhaledloxapine inhaled and lofexidine both increase sedation. Use Caution/Monitor.lumefantrinelumefantrine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.maprotilinemaprotiline and lofexidine both increase sedation. Use Caution/Monitor.maprotiline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.marijuanalofexidine and marijuana both increase sedation. Use Caution/Monitor.melatoninlofexidine and melatonin both increase sedation. Use Caution/Monitor.meperidinemeperidine and lofexidine both increase sedation. Use Caution/Monitor.meprobamatelofexidine and meprobamate both increase sedation. Use Caution/Monitor.metaproterenollofexidine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaxalonemetaxalone and lofexidine both increase sedation. Use Caution/Monitor.methadonemethadone and lofexidine both increase sedation. Use Caution/Monitor.methadone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.methamphetaminelofexidine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methocarbamolmethocarbamol and lofexidine both increase sedation. Use Caution/Monitor.methylenedioxymethamphetaminelofexidine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.midazolammidazolam and lofexidine both increase sedation. Use Caution/Monitor.midodrinelofexidine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mifepristonemifepristone and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.mirabegronmirabegron will increase the level or effect of lofexidine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction.mirtazapinelofexidine and mirtazapine both increase sedation. Use Caution/Monitor.mirtazapine and lofexidine both increase QTc interval. Use Caution/Monitor.modafinillofexidine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.morphinemorphine and lofexidine both increase sedation. Use Caution/Monitor.motherwortlofexidine and motherwort both increase sedation. Use Caution/Monitor.moxifloxacinmoxifloxacin and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.moxonidinelofexidine and moxonidine both increase sedation. Use Caution/Monitor.nabilonelofexidine and nabilone both increase sedation. Use Caution/Monitor.nalbuphinenalbuphine and lofexidine both increase sedation. Use Caution/Monitor.naltrexonelofexidine will decrease the level or effect of naltrexone by unknown mechanism. Modify Therapy/Monitor Closely. Coadministration of lofexidine with oral naltrexone resulted in statistically significant differences in the steady-state pharmacokinetics of naltrexone. The efficacy of oral naltrexone may be reduced if administered within 2 hours of taking lofexidine. Interaction not expected with other naltrexone routes of administration.nilotinibnilotinib and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.norepinephrinelofexidine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.nortriptylinenortriptyline and lofexidine both increase sedation. Use Caution/Monitor.nortriptyline decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.olanzapineolanzapine and lofexidine both increase sedation. Use Caution/Monitor.olanzapine and lofexidine both increase QTc interval. Use Caution/Monitor.opium tinctureopium tincture and lofexidine both increase sedation. Use Caution/Monitor.orphenadrineorphenadrine and lofexidine both increase sedation. Use Caution/Monitor.osilodrostatosilodrostat and lofexidine both increase QTc interval. Use Caution/Monitor.oxaliplatinoxaliplatin will increase the level or effect of lofexidine by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.oxazepamoxazepam and lofexidine both increase sedation. Use Caution/Monitor.oxycodoneoxycodone and lofexidine both increase sedation. Use Caution/Monitor.oxymorphoneoxymorphone and