AdultPediatricDosage Forms & Strengths injectable solution 20mg/mL oral solution 20mg/mL tablets 200mg capsules 200mg lozenges 75mg Fatigue & Drowsiness 100-200 mg PO q3-4hr; not later than 6 hours before bedtime Respiratory Failure Caffeine and sodium benzoate: 250 mg IV/IM once; may repeat PRN; alternatively, 500 mg in 1 L IV over 4 hr; not to exceed 2500 mg/24hr CAUTION: Use strongly discouraged Stimulant Diuretic (Off-label) 500 mg IV/IM; 1 g maximum single doseDosage Forms & Strengths injectable solution 10mg/mL oral solution 10mg/mL tablets 200mg capsules 200mg lozenges 75mg Drowsiness or Fatigue < 12 years: Not recommended >12 years: 100-200 mg PO q3-4hr; not later than 6 hours before bedtime Potential toxic dose <6 years old: 15 mg/kg Neonatal Apnea Load: 10-20 mg/kg IV/PO once Maintenance: 5-10 mg/kg IV/PO qDay Potential toxic dose <6 years old: 15 mg/kgInteraction CheckerEnter a drug name and caffeineNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (7)fezolinetantcaffeine will increase the level or effect of fezolinetant by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Fezolinetant AUC and peak plasma concentration are increased if coadministered with drugs that are weak, moderate, or strong CYP1A2 inhibitorsisocarboxazidisocarboxazid increases effects of caffeine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.linezolidlinezolid increases effects of caffeine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.phenelzinephenelzine increases effects of caffeine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.procarbazineprocarbazine increases effects of caffeine by pharmacodynamic synergism. Contraindicated. Caffeine can produce severe hypertensive crises or dangerous cardiac arrhythmias if administered to patients taking a MAOI. All preparations containing caffeine should be used sparingly.selegiline transdermalselegiline transdermal increases effects of caffeine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.tranylcyprominetranylcypromine increases effects of caffeine by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.Serious - Use Alternative (7)abametapirabametapir will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP1A2 substrates. If not feasible, avoid use of abametapir.bupropioncaffeine increases toxicity of bupropion by unspecified interaction mechanism. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible.dipyridamolecaffeine decreases effects of dipyridamole by pharmacodynamic antagonism. Contraindicated.givosirangivosiran will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP1A2 substrates with givosiran. If unavoidable, decrease the CYP1A2 substrate dosage in accordance with approved product labeling.iobenguane I 131caffeine will decrease the level or effect of iobenguane I 131 by Other (see comment). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Do not administer these drugs until at least 7 days after each iobenguane dose.ozanimodozanimod increases toxicity of caffeine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.regadenosoncaffeine decreases effects of regadenoson by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Avoid methylxanthines for 12 hours before regadenoson administration.Monitor Closely (166)albuterolalbuterol and caffeine both decrease sedation. Use Caution/Monitor.alfentanilalfentanil increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alprazolamalprazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amitriptylineamitriptyline increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amobarbitalamobarbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.amoxapineamoxapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterolarformoterol and caffeine both decrease sedation. Use Caution/Monitor.aripiprazolearipiprazole increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.armodafinilarmodafinil and caffeine both decrease sedation. Use Caution/Monitor.azelastineazelastine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.belladonna and opiumbelladonna and opium increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benperidolbenperidol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.benzphetaminecaffeine and benzphetamine both decrease sedation. Use Caution/Monitor.brompheniraminebrompheniramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.buprenorphine buccalbuprenorphine buccal increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butabarbitalbutabarbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butalbitalbutalbital increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.butorphanolbutorphanol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.carbinoxaminecarbinoxamine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chloral hydratechloral hydrate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlordiazepoxidechlordiazepoxide increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpheniraminechlorpheniramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.chlorpromazinechlorpromazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cinnarizinecinnarizine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ciprofloxacinciprofloxacin will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. The hepatic metabolism of caffeine may be decreased by ciprofloxacin; pharmacologic effects of caffeine may be increased.clemastineclemastine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clomipramineclomipramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clonazepamclonazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clorazepateclorazepate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.clozapineclozapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.codeinecodeine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyclizinecyclizine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.cyproheptadinecyproheptadine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.deferasiroxdeferasirox increases levels of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.desipraminedesipramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexchlorpheniraminedexchlorpheniramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluraminecaffeine and dexfenfluramine both decrease sedation. Use Caution/Monitor.dexmedetomidinedexmedetomidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidatecaffeine and dexmethylphenidate both decrease sedation. Use Caution/Monitor.dextroamphetaminecaffeine and dextroamphetamine both decrease sedation. Use Caution/Monitor.dextromoramidedextromoramide increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphinediamorphine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diethylpropioncaffeine and diethylpropion both decrease sedation. Use Caution/Monitor.difenoxin hcldifenoxin hcl increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dimenhydrinatedimenhydrinate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenhydraminediphenhydramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diphenoxylate hcldiphenoxylate hcl increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dipipanonedipipanone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dobutaminedobutamine and caffeine both decrease sedation. Use Caution/Monitor.dopaminecaffeine and dopamine both decrease sedation. Use Caution/Monitor.dopexaminedopexamine and caffeine both decrease sedation. Use Caution/Monitor.doxepindoxepin increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.droperidoldroperidol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.droxidopacaffeine and droxidopa both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. May increase risk for supine hypertensionephedrineephedrine and caffeine both decrease sedation. Use Caution/Monitor.epinephrineepinephrine and caffeine both decrease sedation. Use Caution/Monitor.epinephrine inhaledcaffeine, epinephrine inhaled. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrine racemicepinephrine racemic and caffeine both decrease sedation. Use Caution/Monitor.esketamine intranasalesketamine intranasal, caffeine. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. .estazolamestazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethanolethanol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethinylestradiolethinylestradiol will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.fenfluraminecaffeine and fenfluramine both decrease sedation. Use Caution/Monitor.fexinidazolefexinidazole will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.fluphenazinefluphenazine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurazepamflurazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.fluvoxaminefluvoxamine will increase the level or effect of caffeine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.formoterolformoterol and caffeine both decrease sedation. Use Caution/Monitor.green teagreen tea increases effects of caffeine by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of CNS stimulation due to caffeine component of green tea. Caution advised.guselkumabguselkumab, caffeine. Other (see comment). Use Caution/Monitor. Comment: Formation of CYP450 enzymes can be altered by increased levels of certain cytokines during chronic inflammation; thus, normalizing the formation of CYP450 enzymes. Upon initiation or discontinuation of guselkumab in patients who are receiving concomitant CYP450 substrates, particularly those with a narrow therapeutic index, consider monitoring for therapeutic effect.haloperidolhaloperidol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydromorphonehydromorphone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.hydroxyzinehydroxyzine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.iloperidoneiloperidone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.imipramineimipramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.isoproterenolisoproterenol and caffeine both decrease sedation. Use Caution/Monitor.ketotifen, ophthalmicketotifen, ophthalmic increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.letermovirletermovir increases levels of caffeine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.levalbuterollevalbuterol and caffeine both decrease sedation. Use Caution/Monitor.levorphanollevorphanol increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.levothyroxinecaffeine decreases levels of levothyroxine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Caffeine (a sympathomimetic) concomitantly used with oral levothyroxine may increase the effects of sympathomimetics or thyroid hormone. Thyroid hormones may increase the risk of coronary insufficiency when sympathomimetic agents are administered to patients with coronary artery disease.lisdexamfetaminecaffeine and lisdexamfetamine both decrease sedation. Use Caution/Monitor.lofepraminelofepramine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lofexidinelofexidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loprazolamloprazolam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lorazepamlorazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lormetazepamlormetazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapineloxapine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.loxapine inhaledloxapine inhaled increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.maprotilinemaprotiline increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.marijuanamarijuana increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.melatoninmelatonin increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meperidinemeperidine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.meprobamatemeprobamate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.metaproterenolmetaproterenol and caffeine both decrease sedation. Use Caution/Monitor.methadonemethadone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methamphetaminecaffeine and methamphetamine both decrease sedation. Use Caution/Monitor.methotrexatecaffeine decreases effects of methotrexate by pharmacodynamic antagonism. Use Caution/Monitor.methylenedioxymethamphetaminecaffeine and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.methylphenidatecaffeine increases effects of methylphenidate