synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. clozapine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.codeineMonitor Closely (1)codeine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.crizotinibMonitor Closely (1)albuterol and crizotinib both increase QTc interval. Use Caution/Monitor.cyclizineMonitor Closely (2)cyclizine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. cyclizine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.cyclobenzaprineMonitor Closely (1)cyclobenzaprine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.cyclopenthiazideMonitor Closely (1)albuterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.cyproheptadineMonitor Closely (1)cyproheptadine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.darifenacinMonitor Closely (1)darifenacin and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.dasatinibMonitor Closely (1)albuterol and dasatinib both increase QTc interval. Use Caution/Monitor.deflazacortMonitor Closely (1)albuterol and deflazacort both decrease serum potassium. Use Caution/Monitor.degarelixMonitor Closely (1)albuterol and degarelix both increase QTc interval. Use Caution/Monitor.desipramineMonitor Closely (3)desipramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. albuterol and desipramine both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)desipramine, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.deutetrabenazineMonitor Closely (1)albuterol and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).dexchlorpheniramineMonitor Closely (1)dexchlorpheniramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexfenfluramineMonitor Closely (2)albuterol and dexfenfluramine both decrease sedation. Use Caution/Monitor. albuterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dexmedetomidineMonitor Closely (1)dexmedetomidine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dexmethylphenidateMonitor Closely (2)albuterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor. albuterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextroamphetamineMonitor Closely (2)albuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor. albuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dextromoramideMonitor Closely (1)dextromoramide increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diamorphineMonitor Closely (1)diamorphine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dichlorphenamideMonitor Closely (2)dichlorphenamide and albuterol both decrease serum potassium. Use Caution/Monitor. dichlorphenamide, albuterol. Either increases levels of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.diclofenacMonitor Closely (1)diclofenac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.dicyclomineMonitor Closely (1)dicyclomine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.diethylpropionMonitor Closely (2)albuterol and diethylpropion both decrease sedation. Use Caution/Monitor. albuterol and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.difenoxin hclMonitor Closely (1)difenoxin hcl increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.diflunisalMonitor Closely (1)diflunisal increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.digoxinMonitor Closely (1)digoxin increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.dimenhydrinateMonitor Closely (1)dimenhydrinate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)dimenhydrinate increases toxicity of ipratropium by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.diphenhydramineMonitor Closely (2)diphenhydramine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. diphenhydramine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.diphenoxylate hclMonitor Closely (1)diphenoxylate hcl increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.dipipanoneMonitor Closely (1)dipipanone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.disopyramideMonitor Closely (1)albuterol and disopyramide both increase QTc interval. Use Caution/Monitor.dobutamineMonitor Closely (3)albuterol and dobutamine both decrease serum potassium. Use Caution/Monitor. albuterol and dobutamine both decrease sedation. Use Caution/Monitor. albuterol and dobutamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dolasetronMonitor Closely (1)albuterol and dolasetron both increase QTc interval. Use Caution/Monitor.donepezilMonitor Closely (2)donepezil and albuterol both increase QTc interval. Use Caution/Monitor. donepezil increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)donepezil decreases effects of ipratropium by pharmacodynamic antagonism. Minor/Significance Unknown.donepezil transdermalMonitor Closely (1)donepezil transdermal, ipratropium. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.dopamineMonitor Closely (2)albuterol and dopamine both decrease sedation. Use Caution/Monitor. albuterol and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dopexamineMonitor Closely (4)dopexamine, albuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. albuterol and dopexamine both decrease serum potassium. Use Caution/Monitor. albuterol and dopexamine both decrease sedation. Use Caution/Monitor. albuterol and dopexamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.dosulepinMonitor Closely (1)ipratropium and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepinMonitor Closely (3)doxepin and albuterol both increase QTc interval. Use Caution/Monitor. doxepin increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.Serious - Use Alternative (1)doxepin, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dronedaroneContraindicated (1)albuterol and dronedarone both increase QTc interval. Contraindicated.droperidolMonitor Closely (5)albuterol and droperidol both increase QTc interval. Use Caution/Monitor. ipratropium decreases levels of droperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. droperidol increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. droperidol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.drospirenoneMonitor Closely (1)drospirenone increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.echothiophate iodideMonitor Closely (1)echothiophate iodide increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.efavirenzMonitor Closely (1)efavirenz and albuterol both increase QTc interval. Use Caution/Monitor.encorafenibMonitor Closely (1)albuterol and encorafenib both increase QTc interval. Use Caution/Monitor.entrectinibMonitor Closely (1)albuterol and entrectinib both increase QTc interval. Use Caution/Monitor.ephedrineMonitor Closely (3)albuterol and ephedrine both decrease serum potassium. Use Caution/Monitor. albuterol and ephedrine both decrease sedation. Use Caution/Monitor. albuterol and ephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrineMonitor Closely (3)albuterol and epinephrine both decrease serum potassium. Use Caution/Monitor. albuterol and epinephrine both decrease sedation. Use Caution/Monitor. albuterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.epinephrine racemicMonitor Closely (3)albuterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor. albuterol and epinephrine racemic both decrease sedation. Use Caution/Monitor. albuterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.eribulinMonitor Closely (1)albuterol and eribulin both increase QTc interval. Use Caution/Monitor.erythromycin baseMonitor Closely (1)albuterol and erythromycin base both increase QTc interval. Use Caution/Monitor.erythromycin ethylsuccinateMonitor Closely (1)albuterol and erythromycin ethylsuccinate both increase QTc interval. Use Caution/Monitor.erythromycin lactobionateMonitor Closely (1)albuterol and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor.erythromycin stearateMonitor Closely (1)albuterol and erythromycin stearate both increase QTc interval. Use Caution/Monitor.escitalopramMonitor Closely (1)albuterol and escitalopram both increase QTc interval. Use Caution/Monitor.esmololMonitor Closely (2)esmolol decreases effects of albuterol by pharmacodynamic antagonism. Use Caution/Monitor. esmolol increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.estazolamMonitor Closely (1)estazolam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.ethacrynic acidMonitor Closely (1)albuterol and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.ethanolMonitor Closely (1)ethanol increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.etodolacMonitor Closely (1)etodolac increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.eucalyptusMinor (1)eucalyptus increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.fenfluramineMonitor Closely (2)albuterol and fenfluramine both decrease sedation. Use Caution/Monitor. albuterol and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.fenoprofenMonitor Closely (1)fenoprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.fesoterodineMonitor Closely (1)fesoterodine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.fexinidazoleMonitor Closely (1)albuterol and fexinidazole both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)fexinidazole and albuterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.fingolimodMonitor Closely (1)fingolimod and albuterol both increase QTc interval. Use Caution/Monitor.flavoxateMonitor Closely (1)flavoxate and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.flecainideMonitor Closely (1)albuterol and flecainide both increase QTc interval. Use Caution/Monitor.fluconazoleMonitor Closely (1)albuterol and fluconazole both increase QTc interval. Use Caution/Monitor.fluoxetineMonitor Closely (1)albuterol and fluoxetine both increase QTc interval. Use Caution/Monitor.fluphenazineMonitor Closely (5)albuterol and fluphenazine both increase QTc interval. Use Caution/Monitor. fluphenazine increases effects of ipratropium by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. ipratropium decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor. fluphenazine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. ipratropium decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.flurazepamMonitor Closely (1)flurazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.flurbiprofenMonitor Closely (1)flurbiprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.formoterolMonitor Closely (3)albuterol and formoterol both decrease serum potassium. Use Caution/Monitor. albuterol and formoterol both decrease sedation. Use Caution/Monitor. albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.foscarnetMonitor Closely (1)albuterol and foscarnet both increase QTc interval. Use Caution/Monitor.fostemsavirMonitor Closely (1)albuterol and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir. furosemideMonitor Closely (1)albuterol and furosemide both decrease serum potassium. Use Caution/Monitor.Minor (1)albuterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.galantamineMonitor Closely (1)galantamine increases and ipratropium decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)galantamine decreases effects of ipratropium by pharmacodynamic antagonism. Minor/Significance Unknown.gemifloxacinMonitor Closely (1)albuterol and gemifloxacin both increase QTc interval. Use Caution/Monitor.gemtuzumabMonitor Closely (1)albuterol and gemtuzumab both increase QTc interval. Use Caution/Monitor.gentamicinMonitor Closely (1)albuterol and gentamicin both decrease serum potassium. Use Caution/Monitor.gilteritinibMonitor Closely (1)albuterol and gilteritinib both increase QTc interval. Use Caution/Monitor.glasdegibMonitor Closely (1)albuterol and glasdegib both increase QTc interval. Use Caution/Monitor.glucagonSerious - Use Alternative (1)glucagon increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .glucagon intranasalSerious - Use Alternative (1)glucagon intranasal increases toxicity of ipratropium by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. .glycopyrrolateMonitor Closely (1)glycopyrrolate and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrrolate inhaledMonitor Closely (1)glycopyrrolate inhaled and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.glycopyrronium tosylate topicalMonitor Closely (1)glycopyrronium tosylate topical, ipratropium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.goserelinMonitor Closely (1)albuterol