antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fexinidazolefexinidazole and trazodone both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.fingolimodfingolimod and trazodone both increase QTc interval. Avoid or Use Alternate Drug.fluconazoletrazodone and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.fluoxetinefluoxetine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.fluphenazinefluphenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.fluvoxaminefluvoxamine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.formoteroltrazodone and formoterol both increase QTc interval. Avoid or Use Alternate Drug.trazodone, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.fosamprenavirfosamprenavir increases levels of trazodone by decreasing metabolism. Avoid or Use Alternate Drug.gemifloxacingemifloxacin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.gilteritinibgilteritinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.glasdegibtrazodone and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.granisetrongranisetron and trazodone both increase QTc interval. Avoid or Use Alternate Drug.guanfacinetrazodone decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.haloperidoltrazodone and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydroxyzinehydroxyzine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.idelalisibidelalisib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substratesimipramineimipramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.inotuzumabinotuzumab and trazodone both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.isofluraneisoflurane and trazodone both increase QTc interval. Avoid or Use Alternate Drug.isoproterenoltrazodone, isoproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.itraconazoleitraconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.ivosidenibivosidenib will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.ketoconazoleketoconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levalbuteroltrazodone, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.levoketoconazolelevoketoconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.levomilnacipranlevomilnacipran and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.linezolidlinezolid and trazodone both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.lisdexamfetaminetrazodone, lisdexamfetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lithiumlithium and trazodone both increase QTc interval. Avoid or Use Alternate Drug.lofepraminelofepramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and lofepramine both increase serotonin levels. Avoid or Use Alternate Drug.lonafarnibtrazodone will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown.lonafarnib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.lopinavirlopinavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.lorcaserintrazodone and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.lumefantrinetrazodone and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.maprotilinemaprotiline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.meperidinetrazodone and meperidine both increase serotonin levels. Avoid or Use Alternate Drug.metaproterenoltrazodone, metaproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.methylene bluemethylene blue and trazodone both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first.methylenedioxymethamphetaminetrazodone, methylenedioxymethamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.midodrinetrazodone, midodrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.mifepristonemifepristone will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.milnacipranmilnacipran and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.mirtazapinemirtazapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.moxifloxacintrazodone and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nefazodonenefazodone will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.nefazodone and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.nevirapinenevirapine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.nilotinibtrazodone and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.norepinephrinetrazodone, norepinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.nortriptylinenortriptyline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and nortriptyline both increase serotonin levels. Avoid or Use Alternate Drug.octreotidetrazodone and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)trazodone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.olanzapineolanzapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.olopatadine intranasaltrazodone and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. oxaliplatinoxaliplatin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.ozanimodozanimod increases levels of trazodone by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.panobinostattrazodone and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.paroxetineparoxetine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.perphenazineperphenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.phendimetrazinetrazodone, phendimetrazine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenterminetrazodone, phentermine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trazodone, phentermine. Either increases toxicity of the other by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of serotonin syndrome.phenylephrinetrazodone, phenylephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.phenylephrine POtrazodone, phenylephrine PO. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.pirbuteroltrazodone, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.pitolisanttrazodone and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.pomalidomidetrazodone decreases levels of pomalidomide by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.posaconazoleposaconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.primaquineprimaquine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.promazinepromazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.propylhexedrinetrazodone, propylhexedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.protriptylineprotriptyline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and protriptyline both increase serotonin levels. Avoid or Use Alternate Drug.pseudoephedrinetrazodone, pseudoephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.rasagilinerasagiline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug. Trazodone should not be coadministered with a MAOI or within 14 days of discontinuing a MAOI. Similarly, a MAOI should not be given within 14 days of stopping trazodone.ribociclibribociclib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifabutinrifabutin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifampinrifampin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.rifapentinerifapentine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.salmeteroltrazodone, salmeterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.selegilineselegiline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.selegiline transdermalselegiline transdermal and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.serdexmethylphenidate/dexmethylphenidatetrazodone, serdexmethylphenidate/dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.sertralinesertraline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.sertraline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.sevofluranesevoflurane and trazodone both increase QTc interval. Avoid or Use Alternate Drug.siponimodsiponimod and trazodone both increase QTc interval. Avoid or Use Alternate Drug.sodium oxybatetrazodone, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients