decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.methylphenidate transdermalmethylphenidate transdermal will increase the level or effect of diazepam by decreasing metabolism. Modify Therapy/Monitor Closely. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. methylprednisolonemethylprednisolone will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.metronidazolemetronidazole will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.miconazole vaginalmiconazole vaginal will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.midazolamdiazepam and midazolam both increase sedation. Use Caution/Monitor.midazolam intranasaldiazepam will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.midazolam intranasal, diazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.midodrinediazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.mirtazapinediazepam and mirtazapine both increase sedation. Use Caution/Monitor.mitotanemitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.morphinediazepam and morphine both increase sedation. Use Caution/Monitor.motherwortdiazepam and motherwort both increase sedation. Use Caution/Monitor.moxonidinediazepam and moxonidine both increase sedation. Use Caution/Monitor.nabilonediazepam and nabilone both increase sedation. Use Caution/Monitor.nalbuphinediazepam and nalbuphine both increase sedation. Use Caution/Monitor.nelfinavirnelfinavir increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available.nevirapinenevirapine will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nifedipinenifedipine will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nilotinibnilotinib will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.nortriptylinediazepam and nortriptyline both increase sedation. Use Caution/Monitor.olanzapinediazepam and olanzapine both increase sedation. Use Caution/Monitor.oliceridineoliceridine, diazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.diazepam increases toxicity of oliceridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC)ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) decreases effects of diazepam by unspecified interaction mechanism. Modify Therapy/Monitor Closely. Increase dose if clinically indicated.opium tincturediazepam and opium tincture both increase sedation. Use Caution/Monitor.orlistatorlistat decreases levels of diazepam by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of convulsions.orphenadrinediazepam and orphenadrine both increase sedation. Use Caution/Monitor.oxazepamdiazepam and oxazepam both increase sedation. Use Caution/Monitor.oxcarbazepineoxcarbazepine will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.oxycodonediazepam and oxycodone both increase sedation. Use Caution/Monitor.oxymorphonediazepam and oxymorphone both increase sedation. Use Caution/Monitor.paliperidonediazepam and paliperidone both increase sedation. Use Caution/Monitor.papaveretumdiazepam and papaveretum both increase sedation. Use Caution/Monitor.papaverinediazepam and papaverine both increase sedation. Use Caution/Monitor.pentazocinediazepam and pentazocine both increase sedation. Use Caution/Monitor.pentobarbitalpentobarbital will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital and diazepam both increase sedation. Use Caution/Monitor.perampanelperampanel and diazepam both increase sedation. Use Caution/Monitor.perphenazinediazepam and perphenazine both increase sedation. Use Caution/Monitor.phenobarbitalphenobarbital will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phenobarbital and diazepam both increase sedation. Use Caution/Monitor.phenylephrine POdiazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .phenytoinphenytoin will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pholcodinediazepam and pholcodine both increase sedation. Use Caution/Monitor.pimozidediazepam and pimozide both increase sedation. Use Caution/Monitor.posaconazoleposaconazole will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.prabotulinumtoxinAdiazepam increases effects of prabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may enhance botulinum toxin effects. Closely monitor for increased neuromuscular blockade.prednisoneprednisone will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pregabalinpregabalin, diazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.primidoneprimidone will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.primidone and diazepam both increase sedation. Use Caution/Monitor.prochlorperazinediazepam and prochlorperazine both increase sedation. Use Caution/Monitor.promethazinepromethazine and diazepam both increase sedation. Use Caution/Monitor.propofolpropofol and diazepam both increase sedation. Use Caution/Monitor.propylhexedrinediazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.protriptylinediazepam and protriptyline both increase sedation. Use Caution/Monitor.quazepamdiazepam and quazepam both increase sedation. Use Caution/Monitor.quetiapinediazepam and quetiapine both increase sedation. Use Caution/Monitor.quinupristin/dalfopristinquinupristin/dalfopristin will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ramelteondiazepam and ramelteon both increase sedation. Use Caution/Monitor.remimazolamremimazolam, diazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.ribociclibribociclib will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.rifapentinerifapentine will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.risperidonediazepam and risperidone both increase sedation. Use Caution/Monitor.ritonavirritonavir increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available.rufinamiderufinamide will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.saquinavirsaquinavir increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use alternatives if available.scullcapdiazepam and scullcap both increase sedation. Use Caution/Monitor.secobarbitalsecobarbital will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.secobarbital and diazepam both increase sedation. Use Caution/Monitor.sevelamersevelamer decreases levels of diazepam by increasing elimination. Use Caution/Monitor.sevofluranesevoflurane and diazepam both increase sedation. Use Caution/Monitor.shepherd's pursediazepam and shepherd's purse both increase sedation. Use Caution/Monitor.sofosbuvir/velpatasvirsofosbuvir/velpatasvir increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Velpatasvir inhibits CYP3A4. Caution if coadministered with drugs with narrow therapeutics indexes.sparsentansparsentan will decrease the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy related to these substrates. stiripentolstiripentol, diazepam. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.stiripentol will decrease the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Consider reducing the dose of CYP2C19 substrates, if adverse reactions are experienced when administered concomitantly with stiripentol.stiripentol, diazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.sufentanildiazepam and sufentanil both increase sedation. Use Caution/Monitor.suvorexantsuvorexant and diazepam both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessarytapentadoldiazepam and tapentadol both increase sedation. Use Caution/Monitor.tazemetostattazemetostat will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.diazepam will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.tecovirimattecovirimat will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Monitor for adverse effects if coadministered with sensitive substrates of these enzymes.tecovirimat will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.teduglutideteduglutide increases levels of diazepam by Other (see comment). Use Caution/Monitor. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary.temazepamdiazepam and temazepam both increase sedation. Use Caution/Monitor.thioridazinediazepam and thioridazine both increase sedation. Use Caution/Monitor.thiothixenediazepam and thiothixene both increase sedation. Use Caution/Monitor.tinidazolediazepam will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.topiramatetopiramate will decrease the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.diazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.tramadoldiazepam and tramadol both increase sedation. Use Caution/Monitor.trazodonediazepam and trazodone both increase sedation. Use Caution/Monitor.triazolamdiazepam and triazolam both increase sedation. Use Caution/Monitor.triclabendazoletriclabendazole will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. If plasma concentrations of the CYP2C19 substrates are elevated during triclabendazole, recheck plasma concentration of the CYP2C19 substrates after discontinuation of triclabendazole. triclofosdiazepam and triclofos both increase sedation. Use Caution/Monitor.trifluoperazinediazepam and trifluoperazine both increase sedation. Use Caution/Monitor.trimipraminediazepam and trimipramine both increase sedation. Use Caution/Monitor.verapamilverapamil will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.voriconazolevoriconazole will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.xylometazolinediazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.zafirlukastzafirlukast will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.ziconotidediazepam and ziconotide both increase sedation. Use Caution/Monitor.ziprasidonediazepam and ziprasidone both increase sedation. Use Caution/Monitor.zotepinediazepam and zotepine both increase sedation. Use Caution/Monitor.diazepam increases levels of zotepine by decreasing metabolism. Use Caution/Monitor.Minor (44)acetaminophendiazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen IVdiazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetaminophen rectaldiazepam decreases levels of acetaminophen rectal by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.acetazolamideacetazolamide will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.anastrozoleanastrozole will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.armodafinilarmodafinil will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.atracuriumdiazepam decreases effects of atracurium by pharmacodynamic antagonism. Minor/Significance Unknown.biotindiazepam decreases levels of biotin by unspecified interaction mechanism. Minor/Significance Unknown. Biotin supplementation may be necessary.brimonidinebrimonidine increases effects of diazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.ciprofloxacinciprofloxacin increases levels of diazepam by decreasing metabolism. Minor/Significance Unknown.cisatracuriumdiazepam decreases effects of cisatracurium by pharmacodynamic antagonism. Minor/Significance Unknown.cyclophosphamidecyclophosphamide will increase the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.dexmethylphenidatedexmethylphenidate increases effects of diazepam by decreasing metabolism. Minor/Significance Unknown.efavirenzefavirenz will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.esomeprazoleesomeprazole will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.etravirineetravirine will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.eucalyptusdiazepam and eucalyptus both increase sedation. Minor/Significance Unknown.felbamatefelbamate will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.fluconazolefluconazole will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.green teagreen tea decreases effects of diazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.labetalollabetalol increases effects of diazepam by decreasing metabolism. Minor/Significance Unknown.metoprololmetoprolol increases effects of diazepam by decreasing metabolism. Minor/Significance Unknown.modafinilmodafinil will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.omeprazoleomeprazole will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.onabotulinumtoxinAdiazepam decreases effects of onabotulinumtoxinA by pharmacodynamic antagonism. Minor/Significance Unknown.oxcarbazepineoxcarbazepine will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.pancuroniumdiazepam decreases effects of pancuronium by pharmacodynamic antagonism. Minor/Significance Unknown.parecoxibparecoxib will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.phenobarbitalphenobarbital will decrease the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.primidoneprimidone will decrease the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Unknown.propranololpropranolol increases effects