AdultPediatricDosage Forms & Strengths budesonide/formoterol inhalation aerosol (Symbicort, generic) (80mcg/4.5mcg)/actuation (160mcg/4.5mcg)/actuation Asthma Treatment in patients whose disease is not adequately controlled by long-term medication or whose disease severity warrants treatment with long-acting beta agonist (LABA) and inhaled corticosteroid 160 mcg/9 mcg (2 actuations of 80 mcg/4.5 mcg) q12hr; for more severe asthma, 320 mcg/9 mcg (2 actuations of 160 mcg/4.5 mcg) q12hr; not to exceed 320 mcg/9 mcg q12hr Chronic Obstructive Pulmonary Disease Treatment of airflow obstruction 160 mcg/9 mcg (2 actuations of 80 mcg/4.5 mcg) q12hr; not to exceed 320 mcg/9 mcg q12hr Dosing Considerations Asthma: If response is inadequate after 1-2 weeks of therapy with 80 mcg/4.5 mcg, switching to 160 mcg/4.5 mcg may provide additional control Chronic obstructive pulmonary disease (COPD): 160 mcg/4.5 mcg is only approved treatment dose; if dyspnea occurs in period between doses, administer inhaled short-acting beta agonist (SABA) for immediate reliefDosage Forms & Strengths budesonide/formoterol inhalation aerosol (Symbicort, generic) (80mcg/4.5mcg)/actuation (160mcg/4.5mcg)/actuation Asthma Indicated for the treatment of asthma in children aged ≥6 years <6 years: Safety and efficacy not established 6-12 years: 160 mcg/9 mcg (2 actuations of 80 mcg/4.5 mcg) q12hr >12 years Starting dose is based on asthma severity 160 mcg/9 mcg (2 actuations of 80 mcg/4.5 mcg) q12hr; for more severe asthma, 320 mcg/9 mcg (2 actuations of 160 mcg/4.5 mcg) q12hr; not to exceed 320 mcg/9 mcg q12hr If response is inadequate after 1-2 weeks of therapy with 80 mcg/4.5 mcg, switching to 160 mcg/4.5 mcg may provide additional control Interaction CheckerEnter a drug name and formoterol/budesonide inhaledNo Results No Interactions Found Interactions FoundContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorAll Interactions Sort By: SeverityName Contraindicated (0)Serious - Use Alternative (72)adagrasibadagrasib, formoterol. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.amisulprideamisulpride and formoterol both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.amitriptylineamitriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.amitriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.amoxapineamoxapine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.amoxapine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.arformoterolarformoterol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrineformoterol and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.chlorpromazinechlorpromazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clarithromycinclarithromycin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clomipramineclomipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.clomipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.desipraminedesipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.desipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.disopyramidedisopyramide and formoterol both increase QTc interval. Avoid or Use Alternate Drug.dofetilidedofetilide and formoterol both increase QTc interval. Avoid or Use Alternate Drug.doxepindoxepin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.doxepin, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.dronedaronedronedarone and formoterol both increase QTc interval. Avoid or Use Alternate Drug.droperidoldroperidol and formoterol both increase QTc interval. Avoid or Use Alternate Drug.entrectinibformoterol and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.epinephrineepinephrine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.epinephrine racemicepinephrine racemic and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin baseerythromycin base and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin ethylsuccinateerythromycin ethylsuccinate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin lactobionateerythromycin lactobionate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.erythromycin stearateerythromycin stearate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.fexinidazolefexinidazole and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fluconazolefluconazole and formoterol both increase QTc interval. Avoid or Use Alternate Drug.fluphenazinefluphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.glasdegibformoterol and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.haloperidolformoterol and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.hydroxychloroquine sulfatehydroxychloroquine sulfate and formoterol both increase QTc interval. Avoid or Use Alternate Drug.ibutilideformoterol and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.imipramineimipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.imipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.indapamideformoterol and indapamide both increase QTc interval. Avoid or Use Alternate Drug.inotuzumabinotuzumab and formoterol both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.isocarboxazidisocarboxazid increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.ivosidenibivosidenib and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.ketoconazoleformoterol and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.lefamulinlefamulin and formoterol both increase QTc interval. Avoid or Use Alternate Drug.levoketoconazoleformoterol and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.linezolidlinezolid increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.lofepraminelofepramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.lofepramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.lonafarniblonafarnib will increase the level or effect of budesonide inhaled by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.lumefantrineformoterol and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.macimorelinbudesonide inhaled, macimorelin. unspecified interaction mechanism. Avoid or Use Alternate Drug. Drugs that directly affect the pituitary secretion of growth hormone (GH) may impact the accuracy of the macimorelin diagnostic test. Allow sufficient washout time of drugs affecting GH growth hormone release before administering prior to administration of macimorelin. Drugs that directly affect the pituitary secretion of growth hormone (GH) may impact the accuracy of the macimorelin diagnostic test. Allow sufficient washout time of drugs affecting GH release before administering macimorelin.macimorelin and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.maprotilinemaprotiline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.maprotiline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.mobocertinibmobocertinib and formoterol both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.moxifloxacinformoterol and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.nilotinibformoterol and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.nortriptylinenortriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.nortriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.octreotideformoterol and octreotide both increase QTc interval. Avoid or Use Alternate Drug.octreotide (Antidote)formoterol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.ondansetronformoterol and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.panobinostatformoterol and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.pentamidineformoterol and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.perphenazineperphenazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.phenelzinephenelzine increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.pimozideformoterol and pimozide both increase QTc interval. Avoid or Use Alternate Drug.pitolisantformoterol and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.primaquineprimaquine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.procainamideformoterol and procainamide both increase QTc interval. Avoid or Use Alternate Drug.prochlorperazineprochlorperazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.promazinepromazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.promethazinepromethazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.protriptylineprotriptyline and formoterol both increase QTc interval. Avoid or Use Alternate Drug.protriptyline, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.quinidinequinidine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.sotalolformoterol and sotalol both increase QTc interval. Avoid or Use Alternate Drug. Drugs known to prolong the QTc interval may potentiate the cardiovascular effects of formoterol.sotalol and formoterol both increase QTc interval. Avoid or Use Alternate Drug. Drugs known to prolong the QTc interval may potentiate the cardiovascular effects of formoterol.thioridazinethioridazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.tranylcyprominetranylcypromine increases effects of formoterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.trazodonetrazodone and formoterol both increase QTc interval. Avoid or Use Alternate Drug.trazodone, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trifluoperazinetrifluoperazine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.trimipraminetrimipramine and formoterol both increase QTc interval. Avoid or Use Alternate Drug.trimipramine, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.umeclidinium bromide/vilanterol inhaledformoterol increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.vilanterol/fluticasone furoate inhaledformoterol increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.ziprasidoneformoterol and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.Monitor Closely (253)acebutololacebutolol increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acebutolol decreases effects of formoterol by pharmacodynamic antagonism. Use Caution/Monitor.aceclofenacaceclofenac increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.acemetacinacemetacin increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterolalbuterol and formoterol both decrease serum potassium. Use Caution/Monitor.albuterol and formoterol both decrease sedation. Use Caution/Monitor.albuterol and formoterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.alfentanilalfentanil increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.alfuzosinformoterol and alfuzosin both increase QTc interval. Use Caution/Monitor.alfuzosin and formoterol both increase QTc interval. Use Caution/Monitor.alprazolamalprazolam increases