[header] How to treat a dog with cushing's disease [title] Give your dog trilostane as prescribed. [step] Trilostane is the treatment of choice for pituitary-dependent canine cushing's disease. It is given by mouth either once or twice daily to block adrenal cortisol production. 
If your vet prescribes twice-daily trilostane, you will give the drug once every 8 to 12 hours with food. [substeps] Although trilostane is more expensive than mitotane, it has fewer side effects and is easier to manage.