[header] How to dissolve gallstones [title] Consider oral dissolution therapy. [step] Your doctor may prescribe a course of ursodiol to dissolve your gallstones without surgery. These treatments are essentially bile acids in pill form. 
Ursodiol, in particular, is a popular treatment because it is one of the safest common drugs available. [substeps] Oral dissolution therapy is most likely to be successful in treating small stones (less than 1.5 centimeters in diameter) with high cholesterol content.