[header] How to diagnose mammary disease in intact female dogs [title] Inspect for abnormal growth. [step] One of the surest signs of mammary gland disease is the growth of abnormal masses underneath the skin. Growths like these are almost always causes of concern and are indicative of some sort of mammary disease. 
[substeps] The majority of abnormal growths on or around the mammary gland are tumors. Tumors may appear as one or may appear in clusters.