[header] How to know if weight loss supplements really work [title] Review published clinical research. [step] You typically can find articles about published research online that has tested the weight loss claims of specific weight-loss supplements. Keep in mind that researchers define " clinically meaningful weight loss " as at least 5 percent of total body weight over the course of a year. 
[substeps] Unfortunately, it may be difficult to find significant studies on the supplements in which you're interested. When you do find studies, look critically at who conducted the research and for what purpose.