[header] How to deal with a knee sprain [title] Rest your knee for the first 48 hours after injury. [step] Rest is the first and most important measure for knee sprain. Rest will not only decrease pain but can also prevent further injury to the knee. 
Consider the use of crutches to keep the weight off your injured knee. [substeps] However, many doctors say that you should actually not keep your injured knee immobile for too long.