[header] How to get published by a major publisher [title] Attend conferences, conventions, and workshops. [step] Writing conferences are a great way to meet other writers, as well as people in the publishing industry. Do a web search for conferences, conventions, or other events for writers in your area. 
If you can, find one that is focused on the genre you are interested in (e.g., science fiction or romance). [substeps] Do some research before the conference to find out who will be there and what kinds of events and panels you can attend.