[header] How to know if you need to change antidepressants [title] Decide if the antidepressant is working. [step] You may need to change antidepressants if they are not working. The goal of any antidepressant is to help your symptoms and make you feel better. 
If the antidepressant isn't working, you may have lingering symptoms or not experience any change in your mood. If this is the case, your doctor will probably want to change your antidepressants.