[header] How to take synthroid [title] Take a whole synthroid tablet once a day. [step] Take the tablet on an empty stomach--between an hour and a half hour before breakfast is a good time. Swallow the tablet whole, instead of chewing or crushing it, with a sip of water. 
[title] Drink a full glass of water after taking the tablet. [step] The synthroid pill can seem large or difficult to swallow.