[header] How to reduce sebum production [title] Get a prescription for retinoids. [step] If you are struggling with excess oil and acne, you may want to talk to a dermatologist about retinoids. This type of medication is one of the most prescribed treatments for acne and excess oil production. 
You can get an oral retinoid, like accutane, or topical medications, like tretinoin, adapalene (which is now available over the counter), tazarotene, and isotretinoin. Oral retinoids are generally more effective than topical ones.