[header] How to treat raw blisters on the palm of your hand [title] Don't pop it unless it really bothers you. [step] Popping the blister makes a hole in your skin. This makes it more vulnerable to infections because it is easier for bacteria and dirt to get inside. 
It also exposes the more tender, underlying skin to use before it is ready, which can be very painful. Instead, you can : [substeps] Wash the area gently with soap and warm water.