[header] How to remove spider veins [title] Undergo sclerotherapy. [step] In this medical procedure, a saline solution or detergent is inserted into the vein, causing it to become irritated and collapse. Once the vein has collapsed, it is no longer visible under the skin. 
You can expect one injection per inch of spider vein. The procedure is quick and usually quite painless-the prick of the needle is the only thing you feel.