[header] How to fend off fatigue [title] Get some sleep. [step] Not getting enough sleep and regular sleep can make a huge difference. If you have trouble sleeping, try taking melatonin, a substance naturally created by your pineal gland (in the brain. 
) it regulates the sleep-wake cycle by chemically causing drowsiness and lowering the body temperature. In patient studies it has helped people restore circadian rhythm, and get back into normal sleep patterns.