b'\n_START_ARTICLE_\nVibrio cholerae\n_START_SECTION_\nFaktory virulence\n_START_PARAGRAPH_\nVibrio cholerae produkuje enterotoxin choleragen, kter\xc3\xbd nen\xc3\xad invazivn\xc3\xad, pouze adheruje na epitel st\xc5\x99eva. ZOT toxin (zonulae occludentes toxin) rozru\xc5\xa1uje tight junction (zonulae occludentes) mezi enterocyty.\n_START_SECTION_\nPatogenita\n_START_PARAGRAPH_\nP\xc5\x99en\xc3\xa1\xc5\xa1\xc3\xad se fek\xc3\xa1ln\xc4\x9b-or\xc3\xa1ln\xc3\xad cestou. Zp\xc5\xafsobuje pr\xc5\xafjmy vypadaj\xc3\xadc\xc3\xad jako r\xc3\xbd\xc5\xbeov\xc3\xa1 voda. Zejm\xc3\xa9na u d\xc4\x9bt\xc3\xad hroz\xc3\xad smrt z dehydratace a ztr\xc3\xa1ta elektrolyt\xc5\xaf.\n_START_SECTION_\nTerapie\n_START_PARAGRAPH_\nHlavn\xc3\xad je zajistit naka\xc5\xbeen\xc3\xa9mu dostatek tekutin. Vibrio cholerae je citliv\xc3\xa9 aminoglykosid\xc5\xafm, zejm\xc3\xa9na gentamycin.'