Select the statement that is true about bilirubin metabolism
A
Indirect bilirubin is formed in the liver by addition of two sugar
B
Macrophages of the spleen liberate bilirubin during Hb catabolism
C
Urobilinogen is not water soluble and is not excreted in urine
D
Normally，the major fraction of bilirubin in the blood is the direct（conjugated）form released from macrophages
E
The small amount of indirect bilirubin in the plasma can been absorbed from the intestine by the portal circulation