PONE-D-23-25168 
 
Dose response of running on blood biomarkers of wellness in the generally healthy 
 
Reviewer: Dr. Subir Gupta 
 
Upon a meticulous review of the article in question, I wish to commend the authors for crafting 
a piece that not only carries immense scientific weight but is also articulated with great clarity. 
Such insightful work surely merits publication in your distinguished journal. It's admirable how 
the authors have navigated through a myriad of physiological and biochemical variables (blood 
biomarkers) across five distinct participant categories and presented their results with lucidity. 
The experimental framework is robust, the statistical evaluations are apt, and the narrative 
progresses seamlessly. The references provided are both relevant and adequate. Nevertheless, 
I'd like to offer a few observations and suggestions: 
 
Original Title: “Dose response of running on blood biomarkers of wellness in the generally 
healthy.” 
Proposed Title: “Dose-response relationship between running and blood biomarkers of 
wellness in generally healthy individuals.” 
 
Page 2, Line 8: The mention of “exposure to sunlight” seems somewhat out of context. Could 
the authors clarify its relevance or indicate if it has been discussed elsewhere in the article? 
 
Page 17, Lines 17-18: The text reads: "These observations suggest that elite endurance 
runners………to their magnesium status." 
Comments: It would be helpful to clarify whether the professional athletes (PRO) participating 
in this study are specifically elite endurance runners. Kindly integrate this distinction into the 
main text if accurate. 
 
Page 19, Lines 1-2: The assertion: “Indeed whether exercise………..is inconclusive,” needs 
to be substantiated with a relevant citation. 
 
Table 1: Please include standard deviation (SD) values. I also recommend expressing exercise 
duration in terms of "h/week" instead of "hr". 

Dose response of running on blood biomarkers of wellness in generally healthy individuals.
Nogal, Bartek,Vinogradova, Svetlana,Jorge, Milena,Torkamani, Ali,Fabian, Paul,Blander, Gil