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There is ingrowth of blood vessels into the cornea , sporadic appearance of goblet cells [ 8,9 ] , and infiltration by inflammatory cells [ 10 ] . However , the fact that our local interviewers found 123 of the 169 positive screening cases ( 72.8 % ) restrained , i.e. chained or locked up , and the overall high average PANSS scores of the examined cases , show that there are ' hard ' criteria , which justify the use of the term ' psychosis ' and validate our screening . We have identified mutations in the H-Ras proto-oncogene as a significant feature of Wnt1-induced tumorigenesis ( Table 1 ) , and we have shown that an inherited Neu transgene or an inherited deficiency of the p53 tumor suppressor gene can provide a selective advantage to Wnt1-expressing mammary cells that overrides the selective advantage conferred by somatic mutation of H-Ras . MMTV-Wnt1 transgenic mice develop mammary hyperplasia early in development , followed by the appearance of solitary mammary tumors with a high proportion of cells expressing early lineage markers and many myoepithelial cells . The left side of each coronal section represents the left hemisphere . We have previously shown that deficiency of p53 dramatically accelerates the appearance of mammary tumors in MMTV-Wnt1 transgenic mice [ 14 ] .