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The juice of it boiled with a little honey and verdigrease , doth wonderfully cleanse fistulas , ulcers , and stays the spreading or eating of cancers and ulcers ; it helps the itch , scabs , wheals , and other breakings out in any part of the body . Among the unresolved issues : modeling large deformations of the surrounding soil due to lateral spreading or other instabilities . Cell-cell and cell-substratum adhesion is mediated by the binding of integrin extracellular domains to diverse protein ligands , however , cellular control of these adhesive interactions and their translation into dynamic cellular responses , such as cell spreading or migration , requires the integrin cytoplasmic tails .