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For those illnesses where primary malignant cells are available in abundance , such as B-CLL ( chronic lymphocytic leukaemia ) , it should be acknowledged further that circulating malignant cells may differ significantly from those that are in contact with non-malignant stromal cells in the bone marrow , lymph nodes and spleen , and that culture conditions in vitro differ dramatically from the complex signalling environment surrounding such malignant cells in vivo . Also , women who have a pathologic diagnosis of atypical hyperplasia or lobular carcinoma in situ are at elevated risk for breast cancer . We showed that hippocampal and cerebellar Purkinje cells in vitro require L-serine , a non-essential amino acid actively released by astroglia , in order to survive and develop . Glycine amide inhibitors of human liver glycogen phosphorylase A with improved potency in vivo are reported.The synthesis , in vitro , and in vivo biological characterization of a series of achiral 5-chloroindoloyl glycine amide inhibitors of human liver glycogen phosphorylase A are described . The nematodes and the damage they cause to plant tissues and to cops in situ are fully illustrated by line drawings and by black-and-white and colour photographs . Scanning electron microscopy has revealed that rete capillary pericytes in situ are connected by their processes into a syncytium . Coimmunoprecipitation experiments in vivo indicate that Trk receptors are in a complex with the 14 kDa light chain and 74 kDa intermediate chain of dynein .