[lemma=□] □
[lemma=buspirone] □
The reason buspirone acts as a full agonist in the raphe nuclei was thought to be because there is a large receptor reserve among autoreceptors in the region , which would make them more sensitive to buspirone than are the postsynaptic 5-HT1A receptors . All patients had received serotonergic antidepressant medication longer than 6 weeks with no improvement before inclusion in the study , and continued the medication for the study duration along with buspirone for 4 to 5 weeks . Based on preclinical and clinical findings in depression and anxiety with depressed mood , a series of controlled trials were undertaken to compare buspirone with placebo in the treatment of major depression .