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They achieve their purpose by pure outline , which floats and dances with the same disregard of substance as thirteenth century illustrations to The Tale of Genji . The FLAME algorithm has intrinsic advantages , such as the ability to capture non-linear relationships and non-globular clusters , the automated definition of the number of clusters , and the identification of cluster outliers , i.e. genes that are not assigned to any cluster . Normal cells within the tumor severely degrade the sensitivity of LOH detection when as few as 10 % are present , but copy-number detection is less sensitive to mixed populations [ 28 ] . The Florentines of the fifteenth century studied Dante in much the same spirit as the Greeks of the fifth century ( whom they so closely resembled ) studied Homer ; for information , for precept and for religious guidance . Our data also suggest that there might be a moderating effect of the number of traumatic experiences on subsequent khat intake . This process was repeated 1000 times to create a distribution of days to all-cause discontinuation from which non-parametric p-values for the mean treatment differences were obtained .