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The cumulative effect of very small corneal scars following chronic failure of wound repair may result in loss of transparency . The main psycho-active component of khat leaves is cathinone ( S ( - ) alpha-aminopropiophenone ) [ 7 ] . However , as soon as he is released the patient engages again in ( often excessive ) khat consumption until symptoms relapse and he is restrained again . Proceeding down the list of matched genomes , the relative counts of YES and NO states were scored at each point for the probability P that the current count y of YES genomes , or greater , could have been encountered by chance among the N genomes encountered so far , as calculated from the binomial distribution . child ex-combatants used khat while fighting in order to counteract fear and enhance performance [ 33 ] . The best score at any point down the list does not necessarily occur when only YES states have been encountered . We found significant correlations between variables of khat consumption and clinical scales ( 0.35 to 0.50 ; p < 0.05 ) , and between the age of onset of khat chewing and symptom onset ( 0.70 ; p < 0.001 ) . Similar to data in live intact tissues , non-invading regions show collagen pulled in near the explant but wrapped around the tumor boundary ( B ) , while at regions of tumor cell invasion into the collagen gel , collagen has been radially aligned by the tumor cells ( white arrow heads C ) with cells ( * ) in direct contact with the collagen matrix ( white arrowheads ; D ) . Therefore , at regions of tumor cell invasion , collagen has been reorganized to a radial alignment from a random orientation , indicating a structural realignment of collagen fibers facilitates local invasion . Combined MPE / SHG imaging of tumor explants cultured within 3D collagen gels for eight hours demonstrates that tumor cells reorganize a previously random matrix to facilitate invasion . This contrasts sharply with the report by D'Cruz et al. [ 3 ] of mutations affecting mostly K-Ras and also N-Ras , but never H-Ras , in mouse mammary tumors induced by an MMTV-c-Myc transgene . In contrast to the high khat consumption prior to the onset of psychotic symptoms , the amount of current khat consumption did not differ between cases with psychotic symptoms and controls and a significant number of patients did not have current access to the drug . The first term ( see below ) of the summation over all possible YES counts from y up to N dominates when YES genomes are relatively rare , but the full summation is performed . Consideration of the properties of the binomial distribution makes it obvious that , for a sparsely distributed property , finding , for instance , eleven genomes with ten marked YES and a single NO will be more significant than finding seven genomes all marked YES ( Table 2 ) . One curious aspect of our findings is the observation of Ras mutations affecting only H-Ras and never K - or N-Ras in Wnt1-induced mammary tumors .