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Dr. Gordis said that the use of alcohol by people with hepatitis C was the worst prognostic factor in the evolution of the disease . On the basis of the relative risk ( RR ) expressed by significant prognostic factors , a score model was developed , and three prognostic groups were defined : Group A , with the best prognostic score , included 23 of 32 ( 72 % ) patients who survived more than 5 years , and that with the worst prognostic score ( group C ) included 22 of 24 ( 92 % ) patients with early diffuse recurrences .