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A list can be constructed using the ACCP risk categories ( see ACCP risk factor assessment guidelines ) . Most cases are due to a point mutation in the factor V gene ( factor V Leiden [ FVL ] ) , which subsequently prevents the cleavage and disruption of activated factor V by APC and thus promotes ongoing clot development . Leadership and strategy , budgets , manpower and technology are all factors delaying modernization . The result that I meant to refer to was that if you have an algorithm that gives you φ ( k ) for any k , you can use the various parts of this problem to factor any n completely .