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By using this Impressionist compositional technique , Boccioni implies not only that his tightly compressed subject is so dynamic that it must burst its four-sided confines , but that it is a fragment of a constantly changing visual experience . The connections between tissue stem cells and aging are still controversial , but it has been demonstrated that changes in mitochondrial properties correlate with reduced competence of adult stem cells [ 27 ] . Yet Botticelli 's brother Simone , with whom he shared a house , was an actual follower of the frate , and one cannot doubt that Botticelli himself was moved by the power of that high , haunting voice which had driven the Florentines into a state of hysteria . Caravaggio 's palette was so muted , and the density of the atmosphere is so great - only the spotlight on the figures penetrates it - that the two-dimensional effect is of a single vast color field with accents placed on it . Our data show that there is no defect per se in the ability of mutant cells to migrate normally , providing they get the correct signals .