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The phase-out of leaded gasoline is but a first step in developing a more comprehensive approach to management of transport-related air pollution . Pollution can travel great distances and cause damage to human health and flora and fauna ; acid rain ; eutrophication of fresh water ; and global and regional climate change . Some equally important impacts , such as personal pain and suffering , and loss of uncompensated labour ( such as child care ) are not adequately captured . Non-toxic and clean-burning dimethyl ether ( DME , sometimes called ‘ synthetic LPG ’ ) shows promise as a clean non-toxic fuel that can meet the same markets now served by LPG . Although Dickens was one of the few major authors to publish regularly in serial format outside of magazine publication , his popularity , beginning with Pickwick Papers in 1836-37 , was immense in the United States as well as in Britain .