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When an order is not set forth on a separate document , what signals litigants that the order is final and appealable is a lack of further activity from the court . The amendment also states that a notice of appeal filed before the disposition of any of the posttrial tolling motions becomes effective upon disposition of the motions . Graduate students entering the Program in Biomedical Science ( PIBS ) at the University of Michigan are offered flexibility in the choice of any of the participating Ph.D. programs , while retaining the small , focused environment of each of the individual training programs . Molecular mechanisms that regulate gene expression and genetic changes that alter regulation are of particular interest . We are examining the effects of exercise stress and distinct classes of neurotoxins on motor neurons . It can thus be determined with certainty precisely when the clerk of the district court must forward the record to the clerk of the court of appeals in order to effect timely filing : the final day of the 40-day period or of any extension thereof . The participants were also able to converse with some of Michigan ' s top doctors about some of the most prevalent neurological diseases .