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In other instances , however , trials may use a placebo for comparison as a way of producing positive results for the drug being tested . In this particular instance , however , they were faced with deciding whether an addition and a deletion of material at one location was one transaction or two , because it was significant in terms of arriving at a price for that line item . In the first instance , however , it is advisable to seek archaeological advice either from the diocese or , if preferred , from the list of archaeological groups . In other instances , however , Ethical Standard 4.04 ( a ) , which is similar to HIPAA 's " minimum necessary " rule , may govern . In such instances , however , the state will not provide funding for roads or road improvements , sewer and water services , schools or other infrastructure needs outside of the pre-determined growth areas unless an exemption is approved by the Maryland Board of Public Works . In the present instance , however , more embarrassment was shown than is usual even with diffident Englishwomen : Miss Helstone felt this , sympathised with the stranger , and knowing by experience what was good for the timid , took a seat quietly near her , and began to talk to her with a gentle ease , communicated for the moment by the presence of one less self-possessed than herself .