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Orthecin TM ( rubitecan , SuperGen , Dublin , CA ) is a new oral agent being investigated for the treatment of patients with pancreatic cancer who have failed at least one prior chemotherapy regimen . In a second Phase III study ( E3200 ) , conducted by the Eastern Cooperative Oncology Group ( ECOG ) , Avastin was also shown to significantly improve survival when added to another widely prescribed chemotherapy regimen ( oxaliplatin / 5-fluorouracil / leucovorin ) . A French trial demonstrated benefits in overall and progression-free survival when interferon followed a doxorubicin-containing chemotherapy regimen to treat patients with poor prognosis ( Solal-Celigny , 1998 ) . Prior to the introduction of this drug , the Mayo Clinic-developed regimen of 5-fluorouracil and leucovorin served as a frequent standard to which other chemotherapy regimens were compared . The aggressive type of NHL has a shorter natural history , but a significant number of these patients can be cured with combination chemotherapy regimens . " Conventional therapy documentation involves all surgery ( e.g ., core biopsy , tissue biopsy , excisional and incisional biopsy , stereotactic biopsies , resections , laparotomy ) ; all chemotherapy regimens ( i.e ., oral , IV , subcutaneous , inpatient , outpatient , and intraoperative ) ; all radiation therapy regimens ( e.g ., gamma knife , intraoperative , hyperfractionated ) ; and a list of all alternative therapies ( including beginning and ending dates , type of intervention , medication names , dosages , length of therapy , and body parts involved ) . Second-line ( salvage ) conventional-dose chemotherapy regimens often are used before HDC in an attempt to achieve minimal disease . Some patients treated with this medicine as part of their chemotherapy regimen for non-small cell lung cancer experienced coughing up of blood from the lungs that was serious and in some cases fatal . According to Angier " there is something to be said for challenging the use of toxic chemotherapy regimens when a cure is out of question . This combination has now become the standard chemotherapy regimen for HD because it is associated with a very low incidence of sterility and leukemia , and it has been shown to be superior in terms of disease-free survival ( DFS ) in a head-to-head comparison with MOPP .