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However , the intensity and speed of propagation of the calcium wave , mediated by release from intracellular stores , was reduced in Pax6 + / - cells . In separate experiments , intracellular calcium stores were depleted by 1 μ M thapsigargin , which inhibits the Ca2 + ATPase pump of the endoplasmic reticulum . More notably , this naturalistic study presents novel and clinically important information about differences in treatment duration between specific atypicals and specific typicals ( of high - , medium - , and low-potency levels ; perphenazine , and haloperidol with prophylactic anticholinergic agents ) . Due to scarce numbers of chronic users for other individual NSAIDs , we could not estimate their respective duration-response relationship . whether the descriptions of symptoms and disability might be adequate for the Somali culture , or whether factors such as interpretation or the interviewing of a whole family rather than a single patient might distort the information . PEP-CTERM proteins appear to be disproportionally present in organisms living in biological niches characterized by substrates such as soils , sediments and biofilms where surface contact is likely to important . Recent data indicate that chronic use of coxibs leads to an increased occurrence of thrombotic cardiovascular events . Conventional Giemsa-stained karyotypes or spectral karyotypes have a resolution of about 1 – 5 Mb . In vivo , the chronic delay in sealing small holes caused by minor abrasion or other cell loss may be sufficient to allow the corneal stroma to become compromised , leading to opacity . It is also important to note that the 3 statistical approaches used in this study and the 5 additional sensitivity analyses did provide consistent findings . The cumulative effect of very small corneal scars following chronic failure of wound repair may result in loss of transparency . The receptors also contain an intracellular signaling domain . Another important difference between the experiments is the size of the wounds , which were very large ( 1000 – 1200 μ m ) in the study by Ramaesh et al [ 59 ] , encompassing up to half the cornea and encroaching on the limbal region . Our aim has been to evaluate the association between the chronic use of tNSAIDs and the risk of myocardial infarction ( MI ) in patients . Inspection of protein markers provides important information about the current state of the cells and data for subsequent manipulations .