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Rotavirus infection is the leading cause of severe diarrhoea and vomiting ( gastroenteritis ) in children under two and kills around 600,000 children each year - one child every minute - mostly in developing countries . The Journal of American History is the leading scholarly journal concerned with the study and investigation of the American past . " Infection is the leading cause of death in these patients . Alcohol intoxication is the leading cause of traffic fatalities in the United States . " According to the Depression and Bipolar Support Alliance , major depression is the leading cause of disability worldwide and costs the U.S. economy $ 70 billion annually in medical expenditures , lost productivity , and other expenses , " says Thaddeus Pace , PhD , lead author on the paper . In the museum context creativity is the leading edge for all services and vital for the development of successful museum programmes that engage the public and broaden access . Depression is the leading cause of disability and costs more in lost productivity than any health problem but heart disease . Major depression is the leading cause of disability both in this country and in the world at large . The repercussions of this are of significant public health concern , because perinatal depression is the leading cause of disease-related disability among women , resulting in depressive episodes and negatively impacting women ’ s children and families . The Centers for Disease Control and Prevention estimates that 4.1 million Americans have been infected with hepatitis C. Approximately 8-10 ,000 hepatitis-C related deaths occur nationally each year , and hepatitis C infection is the leading indication for liver transplants both in Colorado and nationally .