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The histopathologic features show foci of dystrophic calcification in the dermis . Phleboliths may develop as a result of dystrophic calcification in thrombi . Functional improvement of dystrophic muscle by myostatin blockade By pharmacologically manipulating the signaling events important for regulating muscle differentiation , growth and development , a recent paper in Nature by Bogdanovich S et al , " Functional improvement of dystrophic muscle by myostatin blockade , " hopes to provide a novel therapeutic approach for Duchene Muscular Dystrophy , an X-linked recessive progressive muscle wasting disorder . Other complications of dystrophic EB include the development of esophageal webs , constipation , and anal stenosis . In addition , idiopathic scrotal calcinosis may actually represent an end stage of dystrophic calcification of epidermoid cysts in that area of the body.In a study of 39 patients with Gardner syndrome , 13 ( 33 % ) had at least 1 epidermoid cyst .