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In contrast , the domain negative of p300 ( a most potent HAT protein ) could block the inhibition of Cur on histone acetylation ; and the Cur treatment significantly inhibited the HAT activity both in vivo and in vitro . Although use of alcohol , cigarettes , and marijuana increased over time for both sets of students , the rate of increase was significantly less for students who participated in the intervention . SERTR treatment significantly ( p < 0.05 ) increased the severity of convulsions with significant decrease in onset latency . The shift significantly reduced volatile organic material emissions and generated an estimated 50 percent savings in raw materials . With it , health care is significantly enhanced , " said Tom Lasley , dean of the School of Education and Allied Professions.The University of Dayton will construct classrooms , offices , anatomy labs , therapy labs and a physical assessment center on the second floor of College Park Center on Brown Street . The findings indicate that the methadone treatment subjects remained in treatment significantly longer and achieved significantly longer periods of sustained abstinence and a greater proportion of drug free urine tests , compared with subjects who received buprenorphine . I believe the combination of continued growth in world energy demand , the ever-increasing affordability of photovoltaic ( PV ) cells and modules , and growing government incentives for renewable energy sources should drive the global market for solar energy significantly higher over the coming months and years . Researchers found that early treatment significantly reduced the likelihood of poor vision from 19.5 to 14.5 percent at about one year of age .