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Our data suggest , however , that this is not the case , and that the link between genetics of disease and pharmacological correction ( in this case via EGF ) may not be so esoteric . The fold changes are shown on the log2 scale , so the dashed line at zero corresponds to no differential expression , positive values correspond to up-regulation in treated cells , and negative values correspond to down-regulation in treated cells compared with untreated control cells ( see additional file 1 on fold change calculation and gene matching ) . The p values are calculated via the log-rank test . However , the antiviral effect of THC is not cell specific , since MHV 68 and HVS replication was also strongly inhibited by THC in NIH3T12 or owl monkey kidney monolayer cell cultures . Unlike treatment with other antipsychotics , treatment with clozapine requires periodic blood monitoring to assess the risk of developing agranulocytosis . The case control with a positive diagnosis reported hallucinations with intact reality testing during khat intoxication and was replaced by a healthy individual . SupplementaryReport.pdf is a PDFfile containing additional information on the statistical analysis of the expression data and the comparison with the cell - line data , as well as detailed descriptions of additional data files 2 and 3 . The corona radiation was sampled in regions with only nerve fibers and devoid of neuronal soma , thus nuclei are represented in Figure 2 in gray since they were not sampled . Among human Salmonella Enteritidis infections , phage type 4 has been the dominant phage type in most countries in Western Europe during the last years . Treatment group comparisons on time to all-cause medication discontinuation were first made between the atypicals as a group versus typicals as a group , then between the atypicals ( singly and combined ) and typicals of high potency , medium potency , and low potency levels . In humans , drug abuse during puberty has been found to precede the onset of psychotic symptoms and prodromi [ 35 ] and to be related to poorer treatment outcome [ 36 ] . The fifth and last sensitivity analysis was an intent-to-treat ( ITT ) analysis , which unlike previous analyses also included initiators on the index drug who did not have data for at least 1 year following initiation . Figure 1 illustrates the treatment-episodes approach , and the potential for overlap between treatment episodes for any given patient during the 3-year study . To determine the cause of the loss of the endocochlear potential in Slc26a4 - / - mice , we first determined whether intermediate cells are present in stria vascularis , since a loss of intermediate cells is known to lead to a loss of the endocochlear potential [ 27,28 ] . However , unlike aspirin , some , but not all patients , treated chronically with naproxen maintain suppression of thromboxane throughout the whole dosing interval at a level compatible with effective platelet inhibition [ 10,11 ] . Further propagation of calcium rise to cells away from the wound is required for the wound response , which is realized by cell-cell signaling via P2Y receptors and involves predominantly calcium from intracellular stores . We hypothesized that if " sponsor-related physician bias " were present , physicians would have quickly switched patients from their current antipsychotic to olanzapine rather than to risperidone ( olanzapine , risperidone , and clozapine were available for all patients at the time of enrollment , unlike quetiapine and ziprasidone that were not yet available to early study enrollees ) . Patients who were initiated on oral atypical antipsychotics ( clozapine , olanzapine , risperidone , quetiapine , or ziprasidone ) or oral typical antipsychotics ( low , medium , or high potency ) were compared on time to all-cause medication discontinuation for 1 year following initiation . Epithelial sheets react to mechanical injuries via a complex process that relies on coordinated proliferation and migration into the denuded area , matrix deposition and tissue remodeling [ 13-16 ] . Figure 5 presents the probability of discontinuing the medication during the 1 year following initiation for each atypical antipsychotic compared to perphenazine , and Table 5 presents the hazard ratios ( HR ) and 95 % confidence intervals of time to all-cause medication discontinuation of each atypical agent versus perphenazine using the Cox Proportional Hazards regression model . a Calculated via a t-test for age , size , and estrogen-receptor protein , via Fisher 's exact test otherwise .