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Signs or symptoms of hypersensitivity include fever , skin rash , fatigue , gastrointestinal symptoms , and respiratory symptoms , such as pharyngitis , dyspnea , and cough . If symptoms consistent with hypersensitivity are not identified , reintroduction should be undertaken with caution . Rare cases of hypersensitivity have been reported with the use of XENICAL . Several cases of hypersensitivity have been described . It occurs in a minority of patients taking the drug , and no clinical manifestations of hypersensitivity are noted . Symptoms suggestive of hypersensitivity have been noted in approximately 6.6 % of patients . Immediate , presumably allergic , responses such as flare and wheal or various respiratory expressions of hypersensitivity occur extremely rarely after influenza vaccination .